CTNNA2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.80192793
2synaptic vesicle maturation (GO:0016188)5.46045546
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.14565443
4synaptic vesicle exocytosis (GO:0016079)5.10400553
5vocalization behavior (GO:0071625)5.03079215
6neuron cell-cell adhesion (GO:0007158)4.98880838
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.95813142
8locomotory exploration behavior (GO:0035641)4.93532788
9regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.93084169
10protein localization to synapse (GO:0035418)4.87763060
11regulation of synaptic vesicle exocytosis (GO:2000300)4.85423846
12layer formation in cerebral cortex (GO:0021819)4.82773775
13glutamate secretion (GO:0014047)4.66341730
14regulation of glutamate receptor signaling pathway (GO:1900449)4.51466836
15synaptic vesicle docking involved in exocytosis (GO:0016081)4.35212837
16exploration behavior (GO:0035640)4.28433169
17regulation of synaptic vesicle transport (GO:1902803)4.26660751
18ionotropic glutamate receptor signaling pathway (GO:0035235)4.19243437
19dendritic spine morphogenesis (GO:0060997)4.13221751
20neurotransmitter secretion (GO:0007269)4.13136856
21regulation of neuronal synaptic plasticity (GO:0048168)4.09687543
22neuron recognition (GO:0008038)4.07080702
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.94087522
24pyrimidine nucleobase catabolic process (GO:0006208)3.91591475
25axonal fasciculation (GO:0007413)3.88075909
26proline transport (GO:0015824)3.88057013
27synaptic transmission, glutamatergic (GO:0035249)3.84736887
28neuronal action potential propagation (GO:0019227)3.81851658
29glutamate receptor signaling pathway (GO:0007215)3.78724986
30neurotransmitter-gated ion channel clustering (GO:0072578)3.73699721
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.71057849
32regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.69103438
33* dendrite morphogenesis (GO:0048813)3.67819618
34membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.67627054
35positive regulation of synapse maturation (GO:0090129)3.64825160
36neuron-neuron synaptic transmission (GO:0007270)3.64160465
37gamma-aminobutyric acid transport (GO:0015812)3.57241782
38synaptic vesicle endocytosis (GO:0048488)3.56207859
39positive regulation of synaptic transmission, GABAergic (GO:0032230)3.55513758
40auditory behavior (GO:0031223)3.53674330
41* regulation of synapse structural plasticity (GO:0051823)3.51123037
42central nervous system projection neuron axonogenesis (GO:0021952)3.50745862
43positive regulation of dendritic spine morphogenesis (GO:0061003)3.47823425
44central nervous system myelination (GO:0022010)3.45685260
45axon ensheathment in central nervous system (GO:0032291)3.45685260
46startle response (GO:0001964)3.43132222
47response to auditory stimulus (GO:0010996)3.40979396
48negative regulation of microtubule polymerization (GO:0031115)3.39872868
49innervation (GO:0060384)3.39661671
50L-amino acid import (GO:0043092)3.39443629
51cerebellar granule cell differentiation (GO:0021707)3.38118725
52neurotransmitter transport (GO:0006836)3.37892692
53postsynaptic membrane organization (GO:0001941)3.37409419
54* cell migration in hindbrain (GO:0021535)3.37153990
55cerebellar Purkinje cell differentiation (GO:0021702)3.36772747
56neuromuscular synaptic transmission (GO:0007274)3.35885914
57positive regulation of synapse assembly (GO:0051965)3.33619207
58cellular potassium ion homeostasis (GO:0030007)3.32875755
59transmission of nerve impulse (GO:0019226)3.32236151
60regulation of neurotransmitter secretion (GO:0046928)3.32196380
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.31372598
62regulation of excitatory postsynaptic membrane potential (GO:0060079)3.31033835
63synapse assembly (GO:0007416)3.29928747
64long-term memory (GO:0007616)3.29412410
65positive regulation of membrane potential (GO:0045838)3.29371827
66membrane depolarization during action potential (GO:0086010)3.23795649
67regulation of dendritic spine morphogenesis (GO:0061001)3.22401039
68regulation of synaptic transmission, glutamatergic (GO:0051966)3.21755251
69positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.21273874
70sodium ion export (GO:0071436)3.20702833
71regulation of postsynaptic membrane potential (GO:0060078)3.19979764
72mitochondrion transport along microtubule (GO:0047497)3.19874928
73establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.19874928
74positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.19242524
75presynaptic membrane assembly (GO:0097105)3.19207250
76neuromuscular process controlling balance (GO:0050885)3.18125425
77regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17592158
78response to pheromone (GO:0019236)3.17255430
79regulation of synaptic plasticity (GO:0048167)3.15715607
80negative regulation of dendrite development (GO:2000171)3.15050764
81presynaptic membrane organization (GO:0097090)3.14051038
82nucleobase catabolic process (GO:0046113)3.13987275
83positive regulation of dendritic spine development (GO:0060999)3.13745799
84adult walking behavior (GO:0007628)3.12728519
85membrane hyperpolarization (GO:0060081)3.11825697
86activation of protein kinase A activity (GO:0034199)3.10971986
87cell communication by electrical coupling (GO:0010644)3.08675029
88neurofilament cytoskeleton organization (GO:0060052)3.07491975
89regulation of neurotransmitter transport (GO:0051588)3.07111524
90axon cargo transport (GO:0008088)3.06215639
91regulation of neurotransmitter levels (GO:0001505)3.05639203
92neuronal ion channel clustering (GO:0045161)3.04368418
93G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04228699
94regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.03655641
95regulation of voltage-gated calcium channel activity (GO:1901385)3.02549057
96amino acid import (GO:0043090)3.01386458
97mating behavior (GO:0007617)3.00691856
98organelle transport along microtubule (GO:0072384)2.98590465
99vesicle transport along microtubule (GO:0047496)2.97148296
100positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.96157576
101membrane depolarization (GO:0051899)2.96137354
102learning (GO:0007612)2.94898123
103negative regulation of synaptic transmission, GABAergic (GO:0032229)2.94154360
104mechanosensory behavior (GO:0007638)2.92825202
105regulation of vesicle fusion (GO:0031338)2.92647462
106adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.92402048
107regulation of synapse maturation (GO:0090128)2.91546647
108long-term synaptic potentiation (GO:0060291)2.91357791
109gamma-aminobutyric acid signaling pathway (GO:0007214)2.90565274
110synapse organization (GO:0050808)2.90478299
111glycine transport (GO:0015816)2.89695248
112C4-dicarboxylate transport (GO:0015740)2.89064050
113behavioral response to cocaine (GO:0048148)2.88714919
114establishment of mitochondrion localization (GO:0051654)2.87212632
115acidic amino acid transport (GO:0015800)2.86284342
116cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.85742690
117behavioral defense response (GO:0002209)2.85402924
118behavioral fear response (GO:0001662)2.85402924
119synaptic transmission (GO:0007268)2.84578356
120regulation of dendritic spine development (GO:0060998)2.84341517
121negative regulation of cytosolic calcium ion concentration (GO:0051481)2.84277324

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.00992589
2GBX2_23144817_ChIP-Seq_PC3_Human3.49763045
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.07720852
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.05695465
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.92303396
6REST_21632747_ChIP-Seq_MESCs_Mouse2.74493263
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.71329859
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.71329859
9EZH2_27304074_Chip-Seq_ESCs_Mouse2.68565661
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.68563518
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.52003440
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.50859043
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.46270325
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.43916487
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.42772799
16EZH2_27294783_Chip-Seq_ESCs_Mouse2.37346748
17SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35468070
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.31802638
19RARB_27405468_Chip-Seq_BRAIN_Mouse2.30594758
20DROSHA_22980978_ChIP-Seq_HELA_Human2.30306881
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30074151
22EED_16625203_ChIP-ChIP_MESCs_Mouse2.29741518
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.25858827
24CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.25813925
25REST_18959480_ChIP-ChIP_MESCs_Mouse2.21532430
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.11200170
27EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.84252135
28AR_21572438_ChIP-Seq_LNCaP_Human1.83294529
29* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.81934077
30IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77121335
31TAF15_26573619_Chip-Seq_HEK293_Human1.74841050
32MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.65840939
33HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62100833
34* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.60100766
35CTBP1_25329375_ChIP-Seq_LNCAP_Human1.58923258
36CBX2_27304074_Chip-Seq_ESCs_Mouse1.58811807
37PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58803551
38* SMAD4_21799915_ChIP-Seq_A2780_Human1.54231714
39ZFP57_27257070_Chip-Seq_ESCs_Mouse1.53556681
40IGF1R_20145208_ChIP-Seq_DFB_Human1.51648006
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.51227707
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.45716443
43BMI1_23680149_ChIP-Seq_NPCS_Mouse1.44956780
44RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.44818113
45RING1B_27294783_Chip-Seq_ESCs_Mouse1.42659349
46RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36318078
47RNF2_27304074_Chip-Seq_NSC_Mouse1.36044618
48* P300_19829295_ChIP-Seq_ESCs_Human1.32968352
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.31687302
50CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.30408157
51* SOX2_21211035_ChIP-Seq_LN229_Gbm1.28469872
52RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.27302241
53SMAD3_21741376_ChIP-Seq_EPCs_Human1.26775035
54* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26142150
55RING1B_27294783_Chip-Seq_NPCs_Mouse1.25286570
56NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22667629
57* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22331099
58AR_25329375_ChIP-Seq_VCAP_Human1.21602132
59* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.20951042
60P53_22127205_ChIP-Seq_FIBROBLAST_Human1.20341618
61* AR_19668381_ChIP-Seq_PC3_Human1.18526836
62* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.17744402
63* STAT3_23295773_ChIP-Seq_U87_Human1.17408216
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12654478
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.11255357
66WT1_25993318_ChIP-Seq_PODOCYTE_Human1.10851590
67TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.10595962
68* ZNF274_21170338_ChIP-Seq_K562_Hela1.10205574
69GATA1_26923725_Chip-Seq_HPCs_Mouse1.09902976
70AHR_22903824_ChIP-Seq_MCF-7_Human1.09178522
71PIAS1_25552417_ChIP-Seq_VCAP_Human1.09066287
72DNAJC2_21179169_ChIP-ChIP_NT2_Human1.08887992
73ZFP281_18757296_ChIP-ChIP_E14_Mouse1.08065290
74* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.07723773
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07026298
76LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.06767589
77KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.05857088
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05003100
79KDM2B_26808549_Chip-Seq_K562_Human1.03988511
80VDR_22108803_ChIP-Seq_LS180_Human1.02555467
81* TCF4_23295773_ChIP-Seq_U87_Human1.01750088
82* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01438717
83POU3F2_20337985_ChIP-ChIP_501MEL_Human1.00706181
84TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00478194
85VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.00428536
86WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.99808309
87MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.99776112
88* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99642719
89TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.99625038
90POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.99625038
91OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.99209768
92NANOG_18555785_Chip-Seq_ESCs_Mouse0.98886179
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.98673889
94CBP_20019798_ChIP-Seq_JUKART_Human0.98673889
95ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98627465
96SMAD3_21741376_ChIP-Seq_ESCs_Human0.98523895
97SMAD_19615063_ChIP-ChIP_OVARY_Human0.98072053
98* RUNX2_22187159_ChIP-Seq_PCA_Human0.97103876
99SMAD4_21741376_ChIP-Seq_HESCs_Human0.96678174
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.95985166
101NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95761694
102RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.95562915
103TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95396399
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94878965
105CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94565236
106SOX9_26525672_Chip-Seq_HEART_Mouse0.94056016
107EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.93356023
108* PRDM14_20953172_ChIP-Seq_ESCs_Human0.92345421
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.91914640
110UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.91642014
111TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89115488
112TAL1_26923725_Chip-Seq_HPCs_Mouse0.87057191
113KDM2B_26808549_Chip-Seq_REH_Human0.87024632
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86639625
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.86605306
116* JUN_21703547_ChIP-Seq_K562_Human0.84311687
117FUS_26573619_Chip-Seq_HEK293_Human0.82976852

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.83109358
2MP0003880_abnormal_central_pattern4.35195128
3MP0004270_analgesia3.95921729
4* MP0003635_abnormal_synaptic_transmissio3.82520364
5MP0005423_abnormal_somatic_nervous3.27588671
6* MP0002063_abnormal_learning/memory/cond3.19835431
7MP0001968_abnormal_touch/_nociception3.16717759
8MP0009745_abnormal_behavioral_response3.04656468
9MP0002734_abnormal_mechanical_nocicepti2.94312321
10MP0002064_seizures2.86671069
11MP0002735_abnormal_chemical_nociception2.68261179
12MP0009046_muscle_twitch2.66476310
13MP0002572_abnormal_emotion/affect_behav2.63350807
14MP0002736_abnormal_nociception_after2.51041039
15MP0000778_abnormal_nervous_system2.49986512
16MP0002272_abnormal_nervous_system2.41900224
17* MP0001486_abnormal_startle_reflex2.39214568
18MP0002733_abnormal_thermal_nociception2.36709604
19MP0006276_abnormal_autonomic_nervous2.32321960
20MP0004858_abnormal_nervous_system2.25660660
21MP0002184_abnormal_innervation2.21873454
22MP0002822_catalepsy2.20747417
23MP0001970_abnormal_pain_threshold2.18418711
24MP0001440_abnormal_grooming_behavior2.02439877
25MP0004811_abnormal_neuron_physiology1.99516077
26* MP0002067_abnormal_sensory_capabilities1.95115233
27MP0001984_abnormal_olfaction1.85207964
28MP0000955_abnormal_spinal_cord1.84912544
29* MP0002557_abnormal_social/conspecific_i1.80429446
30MP0001501_abnormal_sleep_pattern1.75155012
31MP0003329_amyloid_beta_deposits1.73767386
32MP0004924_abnormal_behavior1.71013915
33MP0005386_behavior/neurological_phenoty1.71013915
34MP0008569_lethality_at_weaning1.68262118
35MP0009780_abnormal_chondrocyte_physiolo1.64549828
36* MP0002882_abnormal_neuron_morphology1.61881976
37MP0005646_abnormal_pituitary_gland1.60584385
38MP0001529_abnormal_vocalization1.51445292
39MP0004885_abnormal_endolymph1.50189319
40MP0005645_abnormal_hypothalamus_physiol1.48837019
41MP0003121_genomic_imprinting1.48787511
42MP0000569_abnormal_digit_pigmentation1.48596326
43MP0002909_abnormal_adrenal_gland1.46294175
44MP0003787_abnormal_imprinting1.42299027
45* MP0002066_abnormal_motor_capabilities/c1.41240261
46MP0001502_abnormal_circadian_rhythm1.28881298
47* MP0002152_abnormal_brain_morphology1.27262077
48MP0005394_taste/olfaction_phenotype1.24258163
49MP0005499_abnormal_olfactory_system1.24258163
50MP0003633_abnormal_nervous_system1.23987290
51MP0003879_abnormal_hair_cell1.23679031
52MP0004142_abnormal_muscle_tone1.22827998
53MP0001188_hyperpigmentation1.21844282
54MP0001905_abnormal_dopamine_level1.19666298
55MP0003122_maternal_imprinting1.18264096
56MP0008877_abnormal_DNA_methylation1.17938078
57MP0005551_abnormal_eye_electrophysiolog1.11023183
58MP0003631_nervous_system_phenotype1.07104745
59MP0010386_abnormal_urinary_bladder1.05388779
60MP0002752_abnormal_somatic_nervous1.04520649
61MP0000631_abnormal_neuroendocrine_gland1.04143832
62MP0003634_abnormal_glial_cell1.04086432
63MP0002229_neurodegeneration1.02288219
64MP0003938_abnormal_ear_development0.96218171
65MP0002069_abnormal_eating/drinking_beha0.94422503
66MP0004133_heterotaxia0.93549202
67MP0002638_abnormal_pupillary_reflex0.93250931
68* MP0003861_abnormal_nervous_system0.87737049
69MP0001963_abnormal_hearing_physiology0.86753604
70MP0001177_atelectasis0.86644160
71MP0002751_abnormal_autonomic_nervous0.85969467
72MP0000751_myopathy0.85221323
73MP0000566_synostosis0.84267032
74MP0000920_abnormal_myelination0.84117471
75MP0006292_abnormal_olfactory_placode0.84111801
76MP0003123_paternal_imprinting0.80594665
77* MP0004742_abnormal_vestibular_system0.79401899
78MP0008789_abnormal_olfactory_epithelium0.79284113
79MP0008961_abnormal_basal_metabolism0.77947340
80MP0004085_abnormal_heartbeat0.77051667
81MP0003137_abnormal_impulse_conducting0.76118820
82MP0003632_abnormal_nervous_system0.75868601
83MP0001299_abnormal_eye_distance/0.75160849
84MP0002090_abnormal_vision0.74348151
85MP0008872_abnormal_physiological_respon0.72285692
86MP0003119_abnormal_digestive_system0.72256692
87MP0004145_abnormal_muscle_electrophysio0.70637147
88MP0003283_abnormal_digestive_organ0.70226834
89MP0001485_abnormal_pinna_reflex0.69730100
90MP0000049_abnormal_middle_ear0.69047416
91MP0002653_abnormal_ependyma_morphology0.67487206
92MP0000604_amyloidosis0.67319258
93MP0005187_abnormal_penis_morphology0.67137037
94MP0006072_abnormal_retinal_apoptosis0.66434086
95MP0001986_abnormal_taste_sensitivity0.66005791
96MP0002102_abnormal_ear_morphology0.64292472
97MP0003690_abnormal_glial_cell0.63040994
98MP0001943_abnormal_respiration0.62680517
99MP0008874_decreased_physiological_sensi0.61936753
100MP0005195_abnormal_posterior_eye0.61778610
101MP0000026_abnormal_inner_ear0.61163857
102MP0005535_abnormal_body_temperature0.60814556
103MP0002234_abnormal_pharynx_morphology0.60702895
104MP0010769_abnormal_survival0.59921765
105MP0002082_postnatal_lethality0.59770819
106MP0010770_preweaning_lethality0.59770819
107MP0001664_abnormal_digestion0.58442229
108MP0005409_darkened_coat_color0.57947457
109MP0003136_yellow_coat_color0.57917057
110MP0004233_abnormal_muscle_weight0.57836594
111* MP0002081_perinatal_lethality0.57734229
112MP0005253_abnormal_eye_physiology0.57545084
113MP0010768_mortality/aging0.56058052
114MP0001348_abnormal_lacrimal_gland0.55525458

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)6.59740926
2Focal motor seizures (HP:0011153)5.98474816
3Focal seizures (HP:0007359)4.93047602
4Visual hallucinations (HP:0002367)4.24958004
5Epileptic encephalopathy (HP:0200134)4.24887497
6Ankle clonus (HP:0011448)4.10688250
7Febrile seizures (HP:0002373)4.02985927
8Progressive cerebellar ataxia (HP:0002073)3.99899499
9Action tremor (HP:0002345)3.87158769
10Supranuclear gaze palsy (HP:0000605)3.81729225
11Atonic seizures (HP:0010819)3.55760203
12Absence seizures (HP:0002121)3.32833624
13Mutism (HP:0002300)3.30321831
14Generalized tonic-clonic seizures (HP:0002069)3.16963462
15Broad-based gait (HP:0002136)3.13384682
16Limb dystonia (HP:0002451)3.13258619
17Urinary bladder sphincter dysfunction (HP:0002839)3.11041045
18Insidious onset (HP:0003587)3.10660262
19Termporal pattern (HP:0011008)3.10660262
20Dialeptic seizures (HP:0011146)3.06914751
21Urinary urgency (HP:0000012)3.01857298
22Impaired vibration sensation in the lower limbs (HP:0002166)2.94847803
23Depression (HP:0000716)2.93356647
24Abnormality of the corticospinal tract (HP:0002492)2.88008193
25Spastic gait (HP:0002064)2.87053055
26Abnormal eating behavior (HP:0100738)2.86138773
27Amblyopia (HP:0000646)2.85329304
28Poor eye contact (HP:0000817)2.84177947
29Excessive salivation (HP:0003781)2.82905524
30Drooling (HP:0002307)2.82905524
31Truncal ataxia (HP:0002078)2.81740300
32Megalencephaly (HP:0001355)2.77425227
33Pheochromocytoma (HP:0002666)2.67928056
34Hyperventilation (HP:0002883)2.63011889
35Polyphagia (HP:0002591)2.61762673
36Hemiparesis (HP:0001269)2.60817077
37Torticollis (HP:0000473)2.57676883
38Impaired social interactions (HP:0000735)2.57030877
39Abnormal social behavior (HP:0012433)2.57030877
40Progressive inability to walk (HP:0002505)2.56741109
41Abnormality of the lower motor neuron (HP:0002366)2.54839011
42Dysdiadochokinesis (HP:0002075)2.54145043
43Dysmetria (HP:0001310)2.52192582
44Gaze-evoked nystagmus (HP:0000640)2.51692106
45Papilledema (HP:0001085)2.51370503
46Anxiety (HP:0000739)2.50638579
47Neurofibrillary tangles (HP:0002185)2.46440094
48Genetic anticipation (HP:0003743)2.45859364
49Split foot (HP:0001839)2.45604326
50Amyotrophic lateral sclerosis (HP:0007354)2.45302483
51Hypoplasia of the brainstem (HP:0002365)2.43719810
52Aplasia/Hypoplasia of the brainstem (HP:0007362)2.43719810
53Postural instability (HP:0002172)2.42302618
54Lower limb muscle weakness (HP:0007340)2.41149163
55Abnormality of the labia minora (HP:0012880)2.35444469
56Fetal akinesia sequence (HP:0001989)2.35345152
57Retinal dysplasia (HP:0007973)2.33656833
58Status epilepticus (HP:0002133)2.33118145
59Agitation (HP:0000713)2.30899816
60Focal dystonia (HP:0004373)2.30684834
61Epileptiform EEG discharges (HP:0011182)2.28701109
62EEG with generalized epileptiform discharges (HP:0011198)2.27842328
63Spastic tetraplegia (HP:0002510)2.25349058
64Insomnia (HP:0100785)2.23245969
65Medial flaring of the eyebrow (HP:0010747)2.22810845
66Failure to thrive in infancy (HP:0001531)2.22526084
67Cerebral inclusion bodies (HP:0100314)2.21796154
68Hemiplegia (HP:0002301)2.21417287
69Neuroendocrine neoplasm (HP:0100634)2.20488503
70Hypsarrhythmia (HP:0002521)2.19975656
71Cortical dysplasia (HP:0002539)2.19852976
72Congenital primary aphakia (HP:0007707)2.18365834
73Stereotypic behavior (HP:0000733)2.16398764
74Craniofacial dystonia (HP:0012179)2.12581773
75Gait imbalance (HP:0002141)2.10820081
76Specific learning disability (HP:0001328)2.10689364
77Lissencephaly (HP:0001339)2.10484455
78Absent speech (HP:0001344)2.10120080
79Bradykinesia (HP:0002067)2.09749074
80Akinesia (HP:0002304)2.09489900
81Inability to walk (HP:0002540)2.07625122
82Clonus (HP:0002169)2.06584505
83Genital tract atresia (HP:0001827)2.06555162
84Abnormality of binocular vision (HP:0011514)2.05909737
85Diplopia (HP:0000651)2.05909737
86Pointed chin (HP:0000307)2.04446826
87Scanning speech (HP:0002168)2.03799642
88Nephrogenic diabetes insipidus (HP:0009806)2.03208916
89Vaginal atresia (HP:0000148)2.01312805
90Ulnar claw (HP:0001178)2.01003141
91Intention tremor (HP:0002080)2.00827415
92Protruding tongue (HP:0010808)1.93610906
93Cerebral hypomyelination (HP:0006808)1.93377266
94Poor suck (HP:0002033)1.92756836
95Abnormality of salivation (HP:0100755)1.91479083
96Impaired smooth pursuit (HP:0007772)1.90472130
97Oligodactyly (hands) (HP:0001180)1.90427405
98Pachygyria (HP:0001302)1.90349488
99Exotropia (HP:0000577)1.90302262
100Optic nerve hypoplasia (HP:0000609)1.88505911
101Inappropriate behavior (HP:0000719)1.88205954
102Aqueductal stenosis (HP:0002410)1.88118739
103Incomplete penetrance (HP:0003829)1.87008456
104Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.85874194
105Morphological abnormality of the pyramidal tract (HP:0002062)1.84532129
106Degeneration of the lateral corticospinal tracts (HP:0002314)1.83949507
107Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83949507
108Hypoventilation (HP:0002791)1.83403031
109Sleep apnea (HP:0010535)1.82871479
110Impaired vibratory sensation (HP:0002495)1.82664330
111Hypoplasia of the corpus callosum (HP:0002079)1.81384568
112Neoplasm of the peripheral nervous system (HP:0100007)1.81040175
113Apathy (HP:0000741)1.80518339
114Nephronophthisis (HP:0000090)1.80329589
115Esotropia (HP:0000565)1.80054374
116Type II lissencephaly (HP:0007260)1.79552659
117Peripheral hypomyelination (HP:0007182)1.78759799
118Ventricular fibrillation (HP:0001663)1.78340493
119Obstructive sleep apnea (HP:0002870)1.77768475
120Blue irides (HP:0000635)1.77644913
121Pancreatic fibrosis (HP:0100732)1.74397921
122True hermaphroditism (HP:0010459)1.73822585
123Intellectual disability, severe (HP:0010864)1.71362906

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK15.15949185
2MAP3K93.70384029
3NTRK33.66142524
4EPHA43.13160553
5MINK12.94776995
6MAP3K42.88760273
7NTRK22.54707815
8MAP2K72.42710777
9DAPK22.23961982
10PAK62.19892183
11MAPK132.05050873
12CASK2.03267922
13KSR21.90467148
14KSR11.90444646
15NTRK11.87381659
16PRKD31.63314448
17PHKG11.61266830
18PHKG21.61266830
19CDK51.58744739
20MAP2K41.58176075
21MAP3K121.54609129
22TNIK1.51286314
23SIK21.46996891
24CAMKK11.46974668
25UHMK11.43558915
26MAP4K21.39603923
27PRPF4B1.28591898
28DYRK21.25387090
29GRK51.19146695
30LATS21.17581650
31SGK4941.16576201
32SGK2231.16576201
33CDK191.15879457
34PLK21.11060116
35PRKCG1.10692741
36TYRO31.09881111
37DAPK11.09758741
38PNCK1.08532146
39ERBB31.08157725
40CSNK1G21.07382931
41MAP3K21.06232046
42LIMK11.06138399
43CDK181.03688826
44CDK141.00869764
45LMTK20.99895956
46CDK150.98639247
47TRIM280.95407229
48RET0.94683652
49RIPK40.93813564
50ARAF0.92887641
51DYRK1A0.90115598
52STK380.88140633
53CDK11A0.86196075
54FRK0.86039561
55SIK30.85551791
56PAK30.83574163
57BCR0.80514006
58CAMK2A0.80375158
59FES0.79712399
60SGK20.79311963
61STK110.76294691
62WNK30.75360716
63EPHA30.73065268
64MARK20.72429584
65CSNK1G30.68100513
66PRKCZ0.67675612
67PRKCH0.67538135
68CAMKK20.66974712
69ADRBK20.65483937
70OXSR10.64764453
71TAOK10.61982945
72RPS6KA20.61370246
73SGK30.60733336
74CSNK1A1L0.59633605
75CAMK10.59344198
76CAMK2B0.58247733
77FGFR20.57767227
78PINK10.55472364
79PKN10.55080931
80SGK10.53935210
81PRKCE0.52924096
82DYRK1B0.52443487
83CAMK2G0.51639857
84FER0.49460443
85BMPR1B0.47832031
86CAMK1G0.47559020
87INSRR0.47552498
88PTK2B0.47406265
89DYRK30.47384020
90ALK0.47162073
91NEK10.47127464
92FYN0.46669195
93EPHB20.45467959
94CSNK1D0.44532363
95ICK0.43552055
96MAPK100.43455574
97MAP2K10.43211032
98RPS6KA30.42330427
99PRKACA0.41407823
100RAF10.39722491
101CDC42BPA0.39703501
102CAMK2D0.38650687
103PRKG10.38550279
104ROCK10.38425608
105ERBB20.37726026
106ROCK20.37623038
107CCNB10.37432333
108CSNK1A10.36696490
109WNK40.36269348
110GRK10.35431174
111* CSNK1E0.35410356
112WNK10.35130821
113CAMK40.32992488
114ADRBK10.32936662
115BMPR20.32805906
116TNK20.32668565
117MAP3K10.31849571
118CSNK1G10.31766453
119NEK60.31735770
120PDK10.31135275
121MAP3K130.31121773
122MAPK150.30282755
123MAPK120.29986054
124PRKCA0.29885386
125PRKCB0.28769663
126* GSK3B0.26959877

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.44577042
2Synaptic vesicle cycle_Homo sapiens_hsa047213.38362870
3Olfactory transduction_Homo sapiens_hsa047402.74374009
4GABAergic synapse_Homo sapiens_hsa047272.67630938
5Circadian entrainment_Homo sapiens_hsa047132.57765847
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.53544844
7Glutamatergic synapse_Homo sapiens_hsa047242.45779513
8Morphine addiction_Homo sapiens_hsa050322.43983803
9Long-term potentiation_Homo sapiens_hsa047202.24124042
10Dopaminergic synapse_Homo sapiens_hsa047282.23544999
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22502853
12Amphetamine addiction_Homo sapiens_hsa050312.10958899
13Cholinergic synapse_Homo sapiens_hsa047252.01171214
14Insulin secretion_Homo sapiens_hsa049111.91021357
15Salivary secretion_Homo sapiens_hsa049701.87949210
16Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.81524396
17Taste transduction_Homo sapiens_hsa047421.74284236
18Serotonergic synapse_Homo sapiens_hsa047261.73395882
19Axon guidance_Homo sapiens_hsa043601.68366251
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.67028514
21Cocaine addiction_Homo sapiens_hsa050301.65589749
22Gastric acid secretion_Homo sapiens_hsa049711.64165833
23Renin secretion_Homo sapiens_hsa049241.62809777
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.60085906
25Long-term depression_Homo sapiens_hsa047301.58511582
26Gap junction_Homo sapiens_hsa045401.53668776
27Oxytocin signaling pathway_Homo sapiens_hsa049211.53440523
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38234727
29GnRH signaling pathway_Homo sapiens_hsa049121.38121121
30Calcium signaling pathway_Homo sapiens_hsa040201.35679616
31Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.34991693
32Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.33715046
33Collecting duct acid secretion_Homo sapiens_hsa049661.33570658
34Type II diabetes mellitus_Homo sapiens_hsa049301.20655381
35ErbB signaling pathway_Homo sapiens_hsa040121.20608217
36Glioma_Homo sapiens_hsa052141.18819823
37cAMP signaling pathway_Homo sapiens_hsa040241.16806015
38Estrogen signaling pathway_Homo sapiens_hsa049151.10381202
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.04971276
40Melanogenesis_Homo sapiens_hsa049161.02977417
41Phosphatidylinositol signaling system_Homo sapiens_hsa040701.02485352
42Butanoate metabolism_Homo sapiens_hsa006501.01654364
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.95426837
44Phototransduction_Homo sapiens_hsa047440.95073661
45cGMP-PKG signaling pathway_Homo sapiens_hsa040220.94125622
46Oocyte meiosis_Homo sapiens_hsa041140.92903744
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90897629
48Cardiac muscle contraction_Homo sapiens_hsa042600.89083780
49Dorso-ventral axis formation_Homo sapiens_hsa043200.87387794
50Vibrio cholerae infection_Homo sapiens_hsa051100.86622265
51Phospholipase D signaling pathway_Homo sapiens_hsa040720.85616991
52Neurotrophin signaling pathway_Homo sapiens_hsa047220.82158653
53Oxidative phosphorylation_Homo sapiens_hsa001900.79576575
54Vascular smooth muscle contraction_Homo sapiens_hsa042700.78220794
55Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78187578
56Choline metabolism in cancer_Homo sapiens_hsa052310.77011118
57Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.76654017
58Parkinsons disease_Homo sapiens_hsa050120.76395409
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.76317741
60Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75391595
61Alzheimers disease_Homo sapiens_hsa050100.75134522
62MAPK signaling pathway_Homo sapiens_hsa040100.74818024
63Colorectal cancer_Homo sapiens_hsa052100.73533686
64Alcoholism_Homo sapiens_hsa050340.72811003
65* Endometrial cancer_Homo sapiens_hsa052130.71183348
66Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71166066
67VEGF signaling pathway_Homo sapiens_hsa043700.70048208
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69129318
69Ras signaling pathway_Homo sapiens_hsa040140.67829238
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.67248495
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66374924
72Renal cell carcinoma_Homo sapiens_hsa052110.66267355
73Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65939860
74Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63740530
75Dilated cardiomyopathy_Homo sapiens_hsa054140.63397097
76Endocytosis_Homo sapiens_hsa041440.62600670
77Pancreatic secretion_Homo sapiens_hsa049720.62479142
78Vitamin B6 metabolism_Homo sapiens_hsa007500.61371630
79Rap1 signaling pathway_Homo sapiens_hsa040150.60267771
80Wnt signaling pathway_Homo sapiens_hsa043100.59330225
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.59132086
82Thyroid hormone synthesis_Homo sapiens_hsa049180.58762033
83Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56112405
84Bile secretion_Homo sapiens_hsa049760.55735692
85mTOR signaling pathway_Homo sapiens_hsa041500.55518363
86* Hippo signaling pathway_Homo sapiens_hsa043900.53206844
87SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52824697
88Ether lipid metabolism_Homo sapiens_hsa005650.52809165
89Insulin signaling pathway_Homo sapiens_hsa049100.52262197
90Non-small cell lung cancer_Homo sapiens_hsa052230.51004243
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49114399
92Regulation of autophagy_Homo sapiens_hsa041400.46905400
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46249479
94Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.45677151
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44469130
96Prion diseases_Homo sapiens_hsa050200.44366657
97Hedgehog signaling pathway_Homo sapiens_hsa043400.44345633
98Glucagon signaling pathway_Homo sapiens_hsa049220.41912570
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.41535806
100Circadian rhythm_Homo sapiens_hsa047100.40488490
101Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.39503727
102Nitrogen metabolism_Homo sapiens_hsa009100.39398037
103* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38009505
104Fatty acid biosynthesis_Homo sapiens_hsa000610.37552703
105Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37207682
106Huntingtons disease_Homo sapiens_hsa050160.36965635
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.36932704
108Inositol phosphate metabolism_Homo sapiens_hsa005620.36831469
109Steroid biosynthesis_Homo sapiens_hsa001000.36653160
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36193018
111Prolactin signaling pathway_Homo sapiens_hsa049170.36174527
112beta-Alanine metabolism_Homo sapiens_hsa004100.35583456
113Chemokine signaling pathway_Homo sapiens_hsa040620.35479560
114Central carbon metabolism in cancer_Homo sapiens_hsa052300.34122035
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.32920923
116Type I diabetes mellitus_Homo sapiens_hsa049400.32338539
117Ovarian steroidogenesis_Homo sapiens_hsa049130.32020325
118Basal cell carcinoma_Homo sapiens_hsa052170.30064891
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.28295569
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.26715846
121* Tight junction_Homo sapiens_hsa045300.25681811
122alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25392439

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