CTNNA3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein that belongs to the vinculin/alpha-catenin family. The encoded protein plays a role in cell-cell adhesion in muscle cells. Mutations in this gene are associated with arrhythmogenic right ventricular dysplasia, familial 13. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)6.79070465
2sarcomere organization (GO:0045214)6.53578150
3myofibril assembly (GO:0030239)6.34727317
4cell communication by electrical coupling (GO:0010644)5.95320928
5muscle filament sliding (GO:0030049)5.91743355
6actin-myosin filament sliding (GO:0033275)5.91743355
7regulation of relaxation of muscle (GO:1901077)5.48252299
8negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.34014092
9membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.30247190
10actin-mediated cell contraction (GO:0070252)5.29026946
11regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)5.27290873
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.24947205
13cardiac muscle contraction (GO:0060048)5.16821110
14cardiac muscle tissue morphogenesis (GO:0055008)5.05480831
15heart contraction (GO:0060047)5.00451245
16heart process (GO:0003015)5.00451245
17regulation of sarcomere organization (GO:0060297)4.97451349
18negative regulation of potassium ion transmembrane transport (GO:1901380)4.92720196
19regulation of skeletal muscle contraction (GO:0014819)4.90794129
20cardiac muscle cell development (GO:0055013)4.88607581
21regulation of actin filament-based movement (GO:1903115)4.82351028
22cardiac muscle hypertrophy (GO:0003300)4.79739074
23adult heart development (GO:0007512)4.74072763
24ventricular cardiac muscle tissue morphogenesis (GO:0055010)4.71246942
25cardiac cell development (GO:0055006)4.65987386
26regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.62292694
27positive regulation of calcium ion transmembrane transporter activity (GO:1901021)4.59043596
28positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.57199662
29motile cilium assembly (GO:0044458)4.51186417
30striated muscle hypertrophy (GO:0014897)4.51006165
31muscle tissue morphogenesis (GO:0060415)4.46102673
32response to stimulus involved in regulation of muscle adaptation (GO:0014874)4.42619278
33actomyosin structure organization (GO:0031032)4.42391803
34striated muscle contraction (GO:0006941)4.40354695
35relaxation of muscle (GO:0090075)4.33132605
36multicellular organism reproduction (GO:0032504)4.28952539
37negative regulation of cardiac muscle cell apoptotic process (GO:0010667)4.22156410
38regulation of cell communication by electrical coupling (GO:0010649)4.21931473
39negative regulation of protein localization to cell surface (GO:2000009)4.20495035
40regulation of striated muscle contraction (GO:0006942)4.15794644
41muscle hypertrophy (GO:0014896)4.08442319
42cell wall macromolecule catabolic process (GO:0016998)4.05023607
43cell wall macromolecule metabolic process (GO:0044036)4.05023607
44sperm motility (GO:0030317)4.02361081
45sodium ion export (GO:0071436)3.99414154
46ventricular cardiac muscle cell action potential (GO:0086005)3.95183638
47negative regulation of skeletal muscle tissue development (GO:0048642)3.94377111
48regulation of membrane repolarization (GO:0060306)3.88902761
49sarcoplasmic reticulum calcium ion transport (GO:0070296)3.87290719
50regulation of calcium ion transmembrane transporter activity (GO:1901019)3.83885348
51regulation of calcium ion transmembrane transport (GO:1903169)3.83885348
52muscle contraction (GO:0006936)3.82397431
53actin filament-based movement (GO:0030048)3.78757081
54cilium or flagellum-dependent cell motility (GO:0001539)3.77798478
55axonemal dynein complex assembly (GO:0070286)3.76754877
56regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.75079493
57acrosome reaction (GO:0007340)3.74919254
58regulation of ATPase activity (GO:0043462)3.73130102
59regulation of ATP catabolic process (GO:1903289)3.73130102
60positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.73089022
61regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.69038078
62negative regulation of striated muscle cell apoptotic process (GO:0010664)3.66477048
63response to caffeine (GO:0031000)3.63980317
64regulation of cardiac muscle contraction (GO:0055117)3.61773423
65negative regulation of cytosolic calcium ion concentration (GO:0051481)3.60080190
66cellular response to epinephrine stimulus (GO:0071872)3.58702553
67bundle of His cell to Purkinje myocyte communication (GO:0086069)3.58444602
68epithelial cilium movement (GO:0003351)3.57000360
69muscle system process (GO:0003012)3.55257631
70regulation of skeletal muscle cell differentiation (GO:2001014)3.54962773
71cardiac ventricle formation (GO:0003211)3.52706794
72cardiac chamber formation (GO:0003207)3.51659337
73regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.50899592
74muscle fiber development (GO:0048747)3.49756925
75positive regulation of cardiac muscle cell differentiation (GO:2000727)3.49696703
76regulation of the force of heart contraction (GO:0002026)3.48004604
77detection of calcium ion (GO:0005513)3.47733757
78fusion of sperm to egg plasma membrane (GO:0007342)3.46068319
79striated muscle cell development (GO:0055002)3.43612637
80relaxation of cardiac muscle (GO:0055119)3.42320594
81regulation of cardiac muscle cell contraction (GO:0086004)3.34331902
82relaxation of smooth muscle (GO:0044557)3.34101061
83piRNA metabolic process (GO:0034587)3.33109238
84cilium movement (GO:0003341)3.29812441
85positive regulation of cation channel activity (GO:2001259)3.28442654
86acrosome assembly (GO:0001675)3.28032929
87cardiac muscle cell action potential (GO:0086001)3.27814737
88striated muscle adaptation (GO:0014888)3.27468074
89reproduction (GO:0000003)3.23528985
90heart trabecula formation (GO:0060347)3.20262202
91ventricular cardiac muscle cell development (GO:0055015)3.18954911
92regulation of cardioblast differentiation (GO:0051890)3.18241719
93positive regulation of sodium ion transport (GO:0010765)3.16907000
94sperm capacitation (GO:0048240)3.15929602
95regulation of muscle system process (GO:0090257)3.15362507
96sperm-egg recognition (GO:0035036)3.14783202
97regulation of heart rate (GO:0002027)3.13738335
98tricarboxylic acid cycle (GO:0006099)3.13713099
99creatine metabolic process (GO:0006600)3.13025079
100mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.12927372
101negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.06921395
102negative regulation of calcium ion transmembrane transport (GO:1903170)3.06921395
103cardiac muscle cell action potential involved in contraction (GO:0086002)3.06695177
104cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.05935270
105muscle cell cellular homeostasis (GO:0046716)3.05336932
106response to epinephrine (GO:0071871)3.04386023
107positive regulation of heart rate (GO:0010460)3.02617333
108cardiac muscle tissue development (GO:0048738)3.02445121
109positive regulation of action potential (GO:0045760)3.01074864
110regulation of muscle contraction (GO:0006937)3.00873476
111regulation of cation channel activity (GO:2001257)3.00053824
112muscle cell development (GO:0055001)2.98413540
113fatty acid transmembrane transport (GO:1902001)2.96845819
114response to muscle activity (GO:0014850)2.96422657
115cardiac conduction (GO:0061337)2.95402885
116cellular sodium ion homeostasis (GO:0006883)2.94275926
117regulation of release of sequestered calcium ion into cytosol (GO:0051279)2.93017172
118negative regulation of muscle hypertrophy (GO:0014741)2.91891236
119cellular response to gamma radiation (GO:0071480)2.91732052
120positive regulation of ion transmembrane transporter activity (GO:0032414)2.90166573
121skeletal muscle contraction (GO:0003009)2.84767213
122cell-cell recognition (GO:0009988)2.83735091
123ubiquinone biosynthetic process (GO:0006744)2.83005589
124quinone biosynthetic process (GO:1901663)2.83005589
125negative regulation of cardiac muscle hypertrophy (GO:0010614)2.81959357
126cardiac muscle hypertrophy in response to stress (GO:0014898)2.81738304
127muscle hypertrophy in response to stress (GO:0003299)2.81738304
128cardiac muscle adaptation (GO:0014887)2.81738304
129regulation of cilium movement (GO:0003352)2.81039056
130cell communication involved in cardiac conduction (GO:0086065)2.80503001
131regulation of heart contraction (GO:0008016)2.79621448
132male meiosis (GO:0007140)2.79322972
133plasma membrane fusion (GO:0045026)2.79092944
134carnitine shuttle (GO:0006853)2.78219025
135adrenergic receptor signaling pathway (GO:0071875)2.76562406
136response to inactivity (GO:0014854)2.76546669
137regulation of heart rate by cardiac conduction (GO:0086091)2.75607372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.97423618
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.68989047
3GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.63916178
4BP1_19119308_ChIP-ChIP_Hs578T_Human2.62827222
5* GBX2_23144817_ChIP-Seq_PC3_Human2.58406189
6EP300_21415370_ChIP-Seq_HL-1_Mouse2.58053578
7PCGF2_27294783_Chip-Seq_ESCs_Mouse2.58003409
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.50167646
9CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.40355247
10VDR_22108803_ChIP-Seq_LS180_Human2.39665027
11* ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29496028
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.08190994
13CDX2_19796622_ChIP-Seq_MESCs_Mouse2.01395330
14PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.01067488
15RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00774552
16SUZ12_27294783_Chip-Seq_NPCs_Mouse2.00388262
17ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.00174599
18POU3F2_20337985_ChIP-ChIP_501MEL_Human1.92861749
19CBX2_27304074_Chip-Seq_ESCs_Mouse1.89396981
20NFE2_27457419_Chip-Seq_LIVER_Mouse1.89232004
21* EZH2_27294783_Chip-Seq_NPCs_Mouse1.73488377
22TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.72274019
23CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.69039905
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.68154013
25EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.67591750
26NANOG_18555785_Chip-Seq_ESCs_Mouse1.66665390
27E2F1_18555785_Chip-Seq_ESCs_Mouse1.64648290
28STAT3_18555785_Chip-Seq_ESCs_Mouse1.63397180
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.61363696
30TAL1_26923725_Chip-Seq_HPCs_Mouse1.59451013
31TAF15_26573619_Chip-Seq_HEK293_Human1.59364589
32P53_22387025_ChIP-Seq_ESCs_Mouse1.58520680
33* SMAD4_21799915_ChIP-Seq_A2780_Human1.57317772
34SUZ12_18555785_Chip-Seq_ESCs_Mouse1.55637583
35SMAD_19615063_ChIP-ChIP_OVARY_Human1.52908660
36NR3C1_23031785_ChIP-Seq_PC12_Mouse1.52741884
37OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.52613226
38SOX2_18555785_Chip-Seq_ESCs_Mouse1.52366903
39MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.51466306
40* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51103859
41EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.50685812
42OCT4_18555785_Chip-Seq_ESCs_Mouse1.50174100
43EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.48838236
44* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.48171663
45ISL1_27105846_Chip-Seq_CPCs_Mouse1.46344020
46CMYC_18555785_Chip-Seq_ESCs_Mouse1.46138230
47SMAD3_21741376_ChIP-Seq_HESCs_Human1.43958321
48NMYC_18555785_Chip-Seq_ESCs_Mouse1.43610602
49P300_18555785_Chip-Seq_ESCs_Mouse1.42616803
50RNF2_18974828_ChIP-Seq_MESCs_Mouse1.42535824
51EZH2_18974828_ChIP-Seq_MESCs_Mouse1.42535824
52ER_23166858_ChIP-Seq_MCF-7_Human1.41301374
53MTF2_20144788_ChIP-Seq_MESCs_Mouse1.40993472
54* SOX2_21211035_ChIP-Seq_LN229_Gbm1.40329114
55* CRX_20693478_ChIP-Seq_RETINA_Mouse1.39327183
56ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39274256
57CTNNB1_20460455_ChIP-Seq_HCT116_Human1.39080618
58SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.38749646
59* P300_19829295_ChIP-Seq_ESCs_Human1.38373916
60CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37621933
61ZFX_18555785_Chip-Seq_ESCs_Mouse1.36488512
62SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.36268754
63KDM2B_26808549_Chip-Seq_REH_Human1.36026127
64KLF4_18555785_Chip-Seq_ESCs_Mouse1.35765388
65RUNX1_27457419_Chip-Seq_LIVER_Mouse1.35401174
66BMI1_23680149_ChIP-Seq_NPCS_Mouse1.34045429
67NRF2_20460467_ChIP-Seq_MEFs_Mouse1.32715752
68NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.32715752
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32646601
70SMAD3_21741376_ChIP-Seq_EPCs_Human1.32548317
71TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32431184
72* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.32090488
73EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31211768
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.29686124
75AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.29630293
76TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29338879
77POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.29338879
78PU1_27457419_Chip-Seq_LIVER_Mouse1.29235299
79EZH2_27304074_Chip-Seq_ESCs_Mouse1.27951852
80RNF2_27304074_Chip-Seq_ESCs_Mouse1.25849981
81* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25750785
82* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25528834
83MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.25423431
84RNF2_27304074_Chip-Seq_NSC_Mouse1.25089429
85CTCF_18555785_Chip-Seq_ESCs_Mouse1.24549030
86NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24495126
87SMAD4_21741376_ChIP-Seq_HESCs_Human1.24435621
88YAP1_20516196_ChIP-Seq_MESCs_Mouse1.23781386
89* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.23768944
90* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.23661780
91PIAS1_25552417_ChIP-Seq_VCAP_Human1.23119831
92SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.22668199
93WT1_19549856_ChIP-ChIP_CCG9911_Human1.22367443
94ESRRB_18555785_Chip-Seq_ESCs_Mouse1.22247514
95* TCF4_23295773_ChIP-Seq_U87_Human1.21749838
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.21178000
97* STAT3_23295773_ChIP-Seq_U87_Human1.20425299
98SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.20349441
99* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20143620
100* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19858784
101EZH2_27294783_Chip-Seq_ESCs_Mouse1.18846307
102LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18615712
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.18448622
104KAP1_22055183_ChIP-Seq_ESCs_Mouse1.17843952
105SMAD1_18555785_Chip-Seq_ESCs_Mouse1.15989960
106FUS_26573619_Chip-Seq_HEK293_Human1.15783061
107RARB_27405468_Chip-Seq_BRAIN_Mouse1.15272520
108PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.15218638
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.14305798
110TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14044215
111JARID2_20075857_ChIP-Seq_MESCs_Mouse1.13550716
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13344424
113* TBL1_22424771_ChIP-Seq_293T_Human1.12548527
114STAT1_17558387_ChIP-Seq_HELA_Human1.12199193
115* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.12012575
116SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.11957418
117TBX20_22328084_ChIP-Seq_HEART_Mouse1.10956022
118TBX20_22080862_ChIP-Seq_HEART_Mouse1.10956022
119AR_21572438_ChIP-Seq_LNCaP_Human1.10577527
120BCAT_22108803_ChIP-Seq_LS180_Human1.09461429
121SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.08449246
122* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07836895
123GF1_26923725_Chip-Seq_HPCs_Mouse1.06419458
124* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.05073516
125* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.04978014
126* AR_19668381_ChIP-Seq_PC3_Human1.04935515
127ESR1_20079471_ChIP-ChIP_T-47D_Human1.04911852
128TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04898811
129* MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.03765564
130DROSHA_22980978_ChIP-Seq_HELA_Human1.03266080
131IGF1R_20145208_ChIP-Seq_DFB_Human1.03218930
132CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.02933000
133* SOX9_26525672_Chip-Seq_HEART_Mouse1.02778528
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.02699533
135ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.02167413
136EED_16625203_ChIP-ChIP_MESCs_Mouse1.01923673
137TRIM28_21343339_ChIP-Seq_HEK293_Human1.01903811
138AHR_22903824_ChIP-Seq_MCF-7_Human1.01357780
139JARID2_20064375_ChIP-Seq_MESCs_Mouse0.98967287
140CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98752687
141* TP53_16413492_ChIP-PET_HCT116_Human0.98642560
142ARNT_22903824_ChIP-Seq_MCF-7_Human0.95759983

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue5.10115246
2MP0002837_dystrophic_cardiac_calcinosis4.87198320
3MP0004084_abnormal_cardiac_muscle4.78458852
4MP0004215_abnormal_myocardial_fiber4.31705910
5MP0000749_muscle_degeneration3.82329166
6MP0004036_abnormal_muscle_relaxation3.76590631
7MP0000751_myopathy3.76462163
8MP0005410_abnormal_fertilization3.38881283
9MP0005330_cardiomyopathy3.10349335
10MP0002972_abnormal_cardiac_muscle2.96342079
11MP0003137_abnormal_impulse_conducting2.80028646
12MP0004145_abnormal_muscle_electrophysio2.74891354
13MP0005451_abnormal_body_composition2.73251038
14MP0005620_abnormal_muscle_contractility2.59715932
15MP0003950_abnormal_plasma_membrane2.52235538
16MP0004510_myositis2.49051220
17MP0008775_abnormal_heart_ventricle2.39202144
18MP0004484_altered_response_of2.27145635
19MP0004087_abnormal_muscle_fiber2.25776164
20MP0002106_abnormal_muscle_physiology2.19269574
21MP0002127_abnormal_cardiovascular_syste2.05743165
22MP0004085_abnormal_heartbeat2.03975322
23MP0001544_abnormal_cardiovascular_syste2.00929398
24MP0005385_cardiovascular_system_phenoty2.00929398
25MP0010630_abnormal_cardiac_muscle1.94991764
26MP0003136_yellow_coat_color1.89241187
27MP0003828_pulmonary_edema1.87306423
28MP0006138_congestive_heart_failure1.83987199
29MP0005369_muscle_phenotype1.78984679
30MP0005171_absent_coat_pigmentation1.78784484
31MP0000750_abnormal_muscle_regeneration1.74412669
32MP0004270_analgesia1.72862993
33MP0005670_abnormal_white_adipose1.68384184
34MP0002269_muscular_atrophy1.64459859
35MP0008877_abnormal_DNA_methylation1.56568682
36MP0003698_abnormal_male_reproductive1.37370362
37MP0001188_hyperpigmentation1.33585158
38MP0001661_extended_life_span1.30335618
39MP0000733_abnormal_muscle_development1.26840964
40MP0001929_abnormal_gametogenesis1.23486344
41MP0000759_abnormal_skeletal_muscle1.22288705
42MP0006292_abnormal_olfactory_placode1.21483964
43MP0009697_abnormal_copulation1.18992363
44MP0003941_abnormal_skin_development1.10466776
45MP0005646_abnormal_pituitary_gland1.06604423
46MP0003221_abnormal_cardiomyocyte_apopto1.06493413
47MP0004233_abnormal_muscle_weight1.03292784
48MP0005423_abnormal_somatic_nervous1.01117651
49MP0006036_abnormal_mitochondrial_physio0.99571801
50MP0002102_abnormal_ear_morphology0.99252503
51MP0004859_abnormal_synaptic_plasticity0.98210507
52MP0001529_abnormal_vocalization0.94480350
53MP0002822_catalepsy0.93581417
54MP0008569_lethality_at_weaning0.93187980
55MP0002735_abnormal_chemical_nociception0.92302944
56MP0000013_abnormal_adipose_tissue0.88391924
57MP0002332_abnormal_exercise_endurance0.87885989
58MP0000747_muscle_weakness0.87169004
59MP0001299_abnormal_eye_distance/0.87165351
60MP0003567_abnormal_fetal_cardiomyocyte0.87060837
61MP0005377_hearing/vestibular/ear_phenot0.86723442
62MP0003878_abnormal_ear_physiology0.86723442
63MP0002210_abnormal_sex_determination0.86620407
64MP0002064_seizures0.86406703
65MP0004272_abnormal_basement_membrane0.85929262
66MP0000462_abnormal_digestive_system0.83114853
67MP0000372_irregular_coat_pigmentation0.82172603
68MP0000343_altered_response_to0.82040477
69MP0003635_abnormal_synaptic_transmissio0.81669365
70MP0003787_abnormal_imprinting0.80946557
71MP0005623_abnormal_meninges_morphology0.79911568
72MP0004130_abnormal_muscle_cell0.79670574
73MP0003690_abnormal_glial_cell0.79433524
74MP0004381_abnormal_hair_follicle0.79088868
75MP0005503_abnormal_tendon_morphology0.78075439
76MP0009745_abnormal_behavioral_response0.77563707
77MP0002638_abnormal_pupillary_reflex0.77530392
78MP0000266_abnormal_heart_morphology0.76175573
79MP0003880_abnormal_central_pattern0.75518284
80MP0010368_abnormal_lymphatic_system0.73992256
81MP0000230_abnormal_systemic_arterial0.73528319
82MP0002734_abnormal_mechanical_nocicepti0.71991557
83MP0001486_abnormal_startle_reflex0.69621006
84MP0004924_abnormal_behavior0.69512989
85MP0005386_behavior/neurological_phenoty0.69512989
86MP0005266_abnormal_metabolism0.68701990
87MP0002108_abnormal_muscle_morphology0.67890104
88MP0000015_abnormal_ear_pigmentation0.67467945
89MP0001984_abnormal_olfaction0.67428830
90MP0005666_abnormal_adipose_tissue0.67188111
91MP0005165_increased_susceptibility_to0.66752304
92MP0000920_abnormal_myelination0.66187129
93MP0004142_abnormal_muscle_tone0.66120451
94MP0002971_abnormal_brown_adipose0.66019394
95MP0003718_maternal_effect0.65391076
96MP0000566_synostosis0.64756675
97MP0010386_abnormal_urinary_bladder0.64452805
98MP0009780_abnormal_chondrocyte_physiolo0.64158885
99MP0000767_abnormal_smooth_muscle0.64074484
100MP0001485_abnormal_pinna_reflex0.64031700
101MP0005248_abnormal_Harderian_gland0.64017206
102MP0005187_abnormal_penis_morphology0.63395685
103MP0005647_abnormal_sex_gland0.62500865
104MP0002128_abnormal_blood_circulation0.62413150
105MP0009046_muscle_twitch0.61262886
106MP0005409_darkened_coat_color0.60371644
107MP0002161_abnormal_fertility/fecundity0.60190285
108MP0003122_maternal_imprinting0.59585329
109MP0002067_abnormal_sensory_capabilities0.59380244
110MP0002736_abnormal_nociception_after0.59189394
111MP0002063_abnormal_learning/memory/cond0.59137419
112MP0001905_abnormal_dopamine_level0.57810051
113MP0002234_abnormal_pharynx_morphology0.57043526
114MP0003279_aneurysm0.55278551
115MP0002163_abnormal_gland_morphology0.54765749
116MP0003879_abnormal_hair_cell0.53542371
117MP0002272_abnormal_nervous_system0.53258871
118MP0004147_increased_porphyrin_level0.52351971
119MP0005595_abnormal_vascular_smooth0.51921412
120MP0008058_abnormal_DNA_repair0.51090734
121MP0003121_genomic_imprinting0.50632963
122MP0009384_cardiac_valve_regurgitation0.50467795
123MP0005253_abnormal_eye_physiology0.50386822
124MP0000653_abnormal_sex_gland0.49682100
125MP0006276_abnormal_autonomic_nervous0.48273602
126MP0002066_abnormal_motor_capabilities/c0.48185402
127MP0002160_abnormal_reproductive_system0.47905881
128MP0003045_fibrosis0.47673419
129MP0003948_abnormal_gas_homeostasis0.47417022
130MP0000579_abnormal_nail_morphology0.47242681
131MP0005551_abnormal_eye_electrophysiolog0.47156984
132MP0000026_abnormal_inner_ear0.46795012
133MP0005375_adipose_tissue_phenotype0.46561859
134MP0003634_abnormal_glial_cell0.40809821
135MP0002572_abnormal_emotion/affect_behav0.40721894
136MP0003633_abnormal_nervous_system0.39277331
137MP0000003_abnormal_adipose_tissue0.37165941
138MP0008874_decreased_physiological_sensi0.36392877
139MP0009250_abnormal_appendicular_skeleto0.35762506
140MP0005167_abnormal_blood-brain_barrier0.35423865
141MP0003937_abnormal_limbs/digits/tail_de0.34586730
142MP0001440_abnormal_grooming_behavior0.33284095
143MP0003329_amyloid_beta_deposits0.33022081

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)7.20832100
2Nemaline bodies (HP:0003798)7.00079212
3Sudden death (HP:0001699)6.63044346
4Type 1 muscle fiber predominance (HP:0003803)5.79729358
5Calf muscle hypertrophy (HP:0008981)5.72143322
6Atrial fibrillation (HP:0005110)5.69180907
7Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.48104771
8Muscle hypertrophy of the lower extremities (HP:0008968)5.24854967
9Primary atrial arrhythmia (HP:0001692)5.16359403
10Supraventricular tachycardia (HP:0004755)4.93013647
11* Ventricular tachycardia (HP:0004756)4.91691051
12Absent/shortened dynein arms (HP:0200106)4.84477063
13Dynein arm defect of respiratory motile cilia (HP:0012255)4.84477063
14Supraventricular arrhythmia (HP:0005115)4.79070524
15Lipoatrophy (HP:0100578)4.69070112
16Syncope (HP:0001279)4.61904261
17Abnormality of the calf musculature (HP:0001430)4.50862323
18Exercise-induced muscle cramps (HP:0003710)4.45983588
19Exercise-induced myalgia (HP:0003738)4.19390714
20Muscle fiber splitting (HP:0003555)4.14935366
21Abnormality of the left ventricular outflow tract (HP:0011103)4.11107977
22Subaortic stenosis (HP:0001682)4.11107977
23Prolonged QT interval (HP:0001657)4.03470984
24Dilated cardiomyopathy (HP:0001644)3.94472796
25Abnormal respiratory motile cilium physiology (HP:0012261)3.79439570
26Difficulty running (HP:0009046)3.78204496
27EMG: neuropathic changes (HP:0003445)3.61516078
28Abnormal ciliary motility (HP:0012262)3.46982827
29Distal arthrogryposis (HP:0005684)3.44423394
30Abnormal respiratory motile cilium morphology (HP:0005938)3.28854607
31Abnormal respiratory epithelium morphology (HP:0012253)3.28854607
32Ventricular arrhythmia (HP:0004308)3.27872195
33Left ventricular hypertrophy (HP:0001712)3.24861439
34Areflexia of lower limbs (HP:0002522)3.18658845
35Acute necrotizing encephalopathy (HP:0006965)3.10755680
36Right ventricular cardiomyopathy (HP:0011663)3.09450796
37Chromosomal breakage induced by crosslinking agents (HP:0003221)3.05834639
38Hyporeflexia of lower limbs (HP:0002600)3.04899566
39Hip contracture (HP:0003273)3.04660830
40EMG: myopathic abnormalities (HP:0003458)3.02672977
41Abnormal mitochondria in muscle tissue (HP:0008316)2.94460484
42Myopathic facies (HP:0002058)2.94333852
43Abnormal EKG (HP:0003115)2.90516650
44Myoglobinuria (HP:0002913)2.88667821
45Palpitations (HP:0001962)2.86079466
46Hypoplastic left heart (HP:0004383)2.74514181
47Abnormality of skeletal muscle fiber size (HP:0012084)2.72153843
48Frequent falls (HP:0002359)2.69797901
49Ventricular fibrillation (HP:0001663)2.69197086
50Steppage gait (HP:0003376)2.69041227
51Congenital malformation of the right heart (HP:0011723)2.66955414
52Double outlet right ventricle (HP:0001719)2.66955414
53Myotonia (HP:0002486)2.64847093
54Increased connective tissue (HP:0009025)2.64447195
55Progressive macrocephaly (HP:0004481)2.63717608
56Chromsome breakage (HP:0040012)2.60399215
57Rhinitis (HP:0012384)2.58708607
58Limited hip movement (HP:0008800)2.57613366
59Increased variability in muscle fiber diameter (HP:0003557)2.56186809
60Round ear (HP:0100830)2.54148921
61Impaired proprioception (HP:0010831)2.52127680
62Asymmetric septal hypertrophy (HP:0001670)2.49743146
63Pulmonary artery stenosis (HP:0004415)2.43502176
64Hypoplastic heart (HP:0001961)2.40147814
65Duplicated collecting system (HP:0000081)2.35942709
66Mildly elevated creatine phosphokinase (HP:0008180)2.31587912
67Palmoplantar keratoderma (HP:0000982)2.30295262
68Acute encephalopathy (HP:0006846)2.29099604
69Mitochondrial inheritance (HP:0001427)2.25914480
70Renal cortical cysts (HP:0000803)2.18243619
71Ulnar claw (HP:0001178)2.16329768
72Exercise intolerance (HP:0003546)2.15582961
73Dysmetric saccades (HP:0000641)2.14463970
74* Heart block (HP:0012722)2.13462931
75Scapular winging (HP:0003691)2.13035644
76* Bundle branch block (HP:0011710)2.12620927
77Ulnar deviation of the wrist (HP:0003049)2.12208362
78Distal lower limb muscle weakness (HP:0009053)2.11441509
79Abnormality of the renal collecting system (HP:0004742)2.11044023
80Rhabdomyolysis (HP:0003201)2.10602000
81Absent phalangeal crease (HP:0006109)2.08409442
82Atrioventricular block (HP:0001678)2.07859563
83Increased CSF lactate (HP:0002490)2.04592981
84Gowers sign (HP:0003391)2.01780268
85Toxemia of pregnancy (HP:0100603)2.01082000
86Fetal akinesia sequence (HP:0001989)2.01039275
87Muscle stiffness (HP:0003552)2.00693399
88Ragged-red muscle fibers (HP:0003200)2.00590689
89Diaphragmatic weakness (HP:0009113)1.99985681
90Nephronophthisis (HP:0000090)1.96975904
91Hepatic necrosis (HP:0002605)1.96849757
92Hyperkalemia (HP:0002153)1.94719179
93* Abnormal atrioventricular conduction (HP:0005150)1.94484208
94Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92377864
95Abnormality of alanine metabolism (HP:0010916)1.92377864
96Hyperalaninemia (HP:0003348)1.92377864
97Abnormality of the foot musculature (HP:0001436)1.90208808
98Neck muscle weakness (HP:0000467)1.90064605
99Weak cry (HP:0001612)1.89390197
100Sudden cardiac death (HP:0001645)1.88681940
101Abnormality of the ischium (HP:0003174)1.87805012
102Generalized muscle weakness (HP:0003324)1.87521040
103Distal lower limb amyotrophy (HP:0008944)1.86959217
104Medial flaring of the eyebrow (HP:0010747)1.85796886
105Optic disc pallor (HP:0000543)1.85232040
106Waddling gait (HP:0002515)1.83702755
107Abnormal connection of the cardiac segments (HP:0011545)1.82818691
108Abnormal ventriculo-arterial connection (HP:0011563)1.82818691
109Transposition of the great arteries (HP:0001669)1.82818691
110Calcaneovalgus deformity (HP:0001848)1.82602361
111Preauricular pit (HP:0004467)1.80918089
112Periauricular skin pits (HP:0100277)1.80918089
113Muscular dystrophy (HP:0003560)1.80640946
114Foot dorsiflexor weakness (HP:0009027)1.80596573
115Focal motor seizures (HP:0011153)1.79374396
116Pheochromocytoma (HP:0002666)1.78533005
117Hepatocellular necrosis (HP:0001404)1.78484984
118Childhood onset (HP:0011463)1.77267411
119Proximal amyotrophy (HP:0007126)1.77051056
120Increased hepatocellular lipid droplets (HP:0006565)1.76781182
121Chronic bronchitis (HP:0004469)1.76105463
122Abnormality of the renal cortex (HP:0011035)1.74275921
123Lipid accumulation in hepatocytes (HP:0006561)1.73934593
124Rimmed vacuoles (HP:0003805)1.73261554
125Lower limb amyotrophy (HP:0007210)1.73123033
126Infertility (HP:0000789)1.73116994
127Centrally nucleated skeletal muscle fibers (HP:0003687)1.71914164
128Abnormality of the shoulder girdle musculature (HP:0001435)1.70960913
129Abnormal finger flexion creases (HP:0006143)1.69394978
130Difficulty climbing stairs (HP:0003551)1.68433790
131Male infertility (HP:0003251)1.68130233
132Bradycardia (HP:0001662)1.67961756
133Bulbar palsy (HP:0001283)1.67849569
134Abnormality of the renal medulla (HP:0100957)1.66245408
135Aplasia/Hypoplasia of the fovea (HP:0008060)1.65714201
136Hypoplasia of the fovea (HP:0007750)1.65714201
137Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.65287526
138Ulnar deviation of finger (HP:0009465)1.63294335
139Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)1.61497796
140Nonprogressive disorder (HP:0003680)1.59219475
141Type 2 muscle fiber atrophy (HP:0003554)1.57638478
142Abnormality of the neuromuscular junction (HP:0003398)1.56348660
143Fatigable weakness (HP:0003473)1.56348660
144Scanning speech (HP:0002168)1.55723762
145Deformed tarsal bones (HP:0008119)1.55347307
146Oligomenorrhea (HP:0000876)1.54848011
147Metatarsus adductus (HP:0001840)1.53581292
148Hypoplastic ischia (HP:0003175)1.50565417
149Progressive muscle weakness (HP:0003323)1.49542536
150Febrile seizures (HP:0002373)1.49455933

Predicted kinase interactions (KEA)

RankGene SetZ-score
1OBSCN5.51983679
2ZAK3.96072178
3MUSK3.65994992
4PDK43.52101620
5PDK33.52101620
6STK38L3.48708523
7PKN23.47716682
8MYLK3.30440258
9STK242.74628739
10DMPK2.38623773
11PDK22.37881884
12MARK12.09650325
13LMTK22.04448320
14PINK12.01694714
15PIK3CA2.00509184
16STK391.91854627
17FLT31.76712519
18PHKG11.73365378
19PHKG21.73365378
20WNK41.63541713
21GRK71.54349367
22INSRR1.50952508
23NUAK11.50737189
24TNIK1.50155721
25TTN1.47490942
26PKN11.42830857
27NEK61.38793449
28TIE11.38233566
29PRKD31.37740613
30CASK1.29565378
31TRPM71.24793697
32PLK41.22645765
33WNK11.18410144
34STK381.17232428
35CAMK2D1.15249096
36MAPK131.12667105
37EPHA41.11623409
38CDC42BPA1.10970829
39UHMK11.10953266
40MAP2K71.10773323
41NTRK31.07507018
42BMPR21.03542844
43BMPR1B1.00565458
44LATS20.96563134
45IRAK30.94736908
46AKT30.93247872
47PTK2B0.87675577
48CAMK2A0.86247701
49STK40.85526600
50SGK20.84275808
51PIK3CG0.83616975
52ROCK10.83529497
53EIF2AK20.82242911
54MAPKAPK50.81567642
55SGK2230.78478446
56SGK4940.78478446
57TTK0.77205107
58LATS10.76162594
59TESK10.75118451
60MAP2K40.72439537
61NTRK20.72191514
62PRKCE0.70070835
63IRAK10.69641950
64CDK30.69539967
65ERBB40.68524418
66RET0.67083974
67TXK0.65903524
68PRKCQ0.61940149
69PRKG10.61580408
70PLK20.61274596
71BRAF0.60427403
72MAPKAPK30.59640758
73MAP3K140.58090373
74CLK10.57650091
75YES10.57423945
76MAPK100.57075130
77MAP3K40.57006315
78PRKAA20.56998024
79BCR0.56064966
80ERBB30.55636684
81PAK30.55349383
82RIPK10.55133815
83PRKD10.55065148
84IRAK40.54919730
85KSR20.54855155
86IRAK20.54274505
87ADRBK20.53069986
88PRKAA10.52090768
89CAMK10.51531496
90STK30.51526583
91ILK0.51505961
92PRKACA0.50856733
93CDK50.50095115
94DYRK20.48110448
95STK110.47408164
96MAPK40.46866107
97CAMK2G0.46380794
98RPS6KA30.45209547
99FGFR10.44749928
100MET0.43836412
101MAP3K60.43359285
102MAP3K50.42771547
103PAK60.42289198
104PRPF4B0.41640253
105MAP3K70.41196062
106PRKACB0.41088138
107PDK10.40902847
108AKT20.40427834
109LIMK10.40303683
110MKNK20.39537538
111FGFR20.38407325
112STK160.38055078
113PRKACG0.36348233
114ROCK20.35936902
115MAPK120.35590630
116MAP2K10.34987656
117NEK10.32834918
118MARK20.32619504
119MAP3K90.32448591
120TEC0.32136738
121FRK0.30974625
122RAF10.29787320
123TAOK30.27628536
124CAMK40.27574662
125SGK10.27048381
126MOS0.26753638
127SRPK10.26473037
128MAPK70.26303439
129KSR10.25057419
130ICK0.24574571
131SGK30.22990183
132CAMK2B0.21956897
133CCNB10.21784166
134NEK90.21695515
135EPHA30.21537903
136GRK10.21379992
137DAPK20.20883887
138DYRK1B0.20244564
139PDGFRA0.20071844
140MAP3K130.18496566
141PNCK0.18142870
142JAK20.17683893
143DYRK1A0.17163096
144EEF2K0.17108881
145PRKDC0.16358141

Predicted pathways (KEGG)

RankGene SetZ-score
1Cardiac muscle contraction_Homo sapiens_hsa042604.63439095
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054104.14736977
3Dilated cardiomyopathy_Homo sapiens_hsa054143.85179659
4Oxidative phosphorylation_Homo sapiens_hsa001903.35299260
5Parkinsons disease_Homo sapiens_hsa050123.11912963
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.97018764
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95609343
8Huntingtons disease_Homo sapiens_hsa050162.63099975
9* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.61230649
10Propanoate metabolism_Homo sapiens_hsa006402.48456375
11Alzheimers disease_Homo sapiens_hsa050102.43997996
12Fatty acid elongation_Homo sapiens_hsa000622.32811355
13Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.80614796
14Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.66154455
15Fanconi anemia pathway_Homo sapiens_hsa034601.56149485
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54869310
17Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.54518605
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.51827823
19Viral myocarditis_Homo sapiens_hsa054161.51635444
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47512885
21Gastric acid secretion_Homo sapiens_hsa049711.47150842
22Linoleic acid metabolism_Homo sapiens_hsa005911.46258724
23Pyruvate metabolism_Homo sapiens_hsa006201.41611656
24alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.40526690
25Ether lipid metabolism_Homo sapiens_hsa005651.33319860
26Arachidonic acid metabolism_Homo sapiens_hsa005901.32835663
27Long-term potentiation_Homo sapiens_hsa047201.29519261
28Calcium signaling pathway_Homo sapiens_hsa040201.27685478
29Taste transduction_Homo sapiens_hsa047421.26087578
30Basal transcription factors_Homo sapiens_hsa030221.24535731
31cGMP-PKG signaling pathway_Homo sapiens_hsa040221.24308668
32Fatty acid metabolism_Homo sapiens_hsa012121.24003674
33Insulin signaling pathway_Homo sapiens_hsa049101.22092961
34Vascular smooth muscle contraction_Homo sapiens_hsa042701.16491468
35Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.15159167
36Fatty acid degradation_Homo sapiens_hsa000711.14085309
37Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.13337900
38Nicotine addiction_Homo sapiens_hsa050331.11438704
39Salivary secretion_Homo sapiens_hsa049701.10364557
40Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.08190695
41Pancreatic secretion_Homo sapiens_hsa049721.02714256
42Insulin resistance_Homo sapiens_hsa049311.01686371
43Thyroid hormone signaling pathway_Homo sapiens_hsa049191.01040413
44Ovarian steroidogenesis_Homo sapiens_hsa049130.98633021
45Circadian rhythm_Homo sapiens_hsa047100.96275876
46Arginine biosynthesis_Homo sapiens_hsa002200.94339840
47Carbon metabolism_Homo sapiens_hsa012000.93347520
48Circadian entrainment_Homo sapiens_hsa047130.92580211
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.91487638
50Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.91096667
51RNA degradation_Homo sapiens_hsa030180.90178793
52Bile secretion_Homo sapiens_hsa049760.87679319
53Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87558780
54Vitamin B6 metabolism_Homo sapiens_hsa007500.84867883
55Intestinal immune network for IgA production_Homo sapiens_hsa046720.84595751
56Morphine addiction_Homo sapiens_hsa050320.84223496
57Autoimmune thyroid disease_Homo sapiens_hsa053200.83830856
58Gap junction_Homo sapiens_hsa045400.82265390
59PPAR signaling pathway_Homo sapiens_hsa033200.81572985
60Graft-versus-host disease_Homo sapiens_hsa053320.81332694
61AMPK signaling pathway_Homo sapiens_hsa041520.81234440
62GnRH signaling pathway_Homo sapiens_hsa049120.80923609
63Insulin secretion_Homo sapiens_hsa049110.78375941
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.77911984
65Adipocytokine signaling pathway_Homo sapiens_hsa049200.76347635
66Dopaminergic synapse_Homo sapiens_hsa047280.76136222
67Glucagon signaling pathway_Homo sapiens_hsa049220.74840494
68Fatty acid biosynthesis_Homo sapiens_hsa000610.74351622
69cAMP signaling pathway_Homo sapiens_hsa040240.74118753
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.73821138
71Serotonergic synapse_Homo sapiens_hsa047260.73523789
72Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.71990635
73* Tight junction_Homo sapiens_hsa045300.70495521
74Purine metabolism_Homo sapiens_hsa002300.69277567
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.69139723
76Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.67258074
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.65293113
78Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.65180635
79Phenylalanine metabolism_Homo sapiens_hsa003600.62067392
80Longevity regulating pathway - mammal_Homo sapiens_hsa042110.60904187
81Oxytocin signaling pathway_Homo sapiens_hsa049210.60598438
82Allograft rejection_Homo sapiens_hsa053300.60463409
83Glutamatergic synapse_Homo sapiens_hsa047240.60301060
84Long-term depression_Homo sapiens_hsa047300.60192608
85Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.59209441
86Sphingolipid metabolism_Homo sapiens_hsa006000.58996181
87Histidine metabolism_Homo sapiens_hsa003400.57915066
88Renin secretion_Homo sapiens_hsa049240.56905093
89ECM-receptor interaction_Homo sapiens_hsa045120.56710811
90Olfactory transduction_Homo sapiens_hsa047400.54851070
91Phospholipase D signaling pathway_Homo sapiens_hsa040720.53356247
92Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.52712234
93Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51476364
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51476237
95Steroid biosynthesis_Homo sapiens_hsa001000.51425109
96Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50950363
97Melanogenesis_Homo sapiens_hsa049160.50896551
98Arginine and proline metabolism_Homo sapiens_hsa003300.50850914
99Homologous recombination_Homo sapiens_hsa034400.50248481
100Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50131078
101Cocaine addiction_Homo sapiens_hsa050300.49499542
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46600433
103MAPK signaling pathway_Homo sapiens_hsa040100.46322183
104Metabolic pathways_Homo sapiens_hsa011000.45657344
105Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44054478
106Estrogen signaling pathway_Homo sapiens_hsa049150.43959544
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.43390976
108Protein digestion and absorption_Homo sapiens_hsa049740.43317791
109Dorso-ventral axis formation_Homo sapiens_hsa043200.42940407
110Thyroid hormone synthesis_Homo sapiens_hsa049180.42865706
111beta-Alanine metabolism_Homo sapiens_hsa004100.42687852
112Type II diabetes mellitus_Homo sapiens_hsa049300.42033756
113Regulation of actin cytoskeleton_Homo sapiens_hsa048100.41892136
114Amoebiasis_Homo sapiens_hsa051460.41398855
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.37454632
116Nitrogen metabolism_Homo sapiens_hsa009100.37166791
117Regulation of autophagy_Homo sapiens_hsa041400.34202133
118Pentose phosphate pathway_Homo sapiens_hsa000300.33799380
119FoxO signaling pathway_Homo sapiens_hsa040680.33567448
120Butanoate metabolism_Homo sapiens_hsa006500.33325038
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.33240916
122Platelet activation_Homo sapiens_hsa046110.33169582
123Oocyte meiosis_Homo sapiens_hsa041140.31839643
124Amphetamine addiction_Homo sapiens_hsa050310.31404151
125Focal adhesion_Homo sapiens_hsa045100.31362872
126Asthma_Homo sapiens_hsa053100.31130178
127ABC transporters_Homo sapiens_hsa020100.30525595
128Rheumatoid arthritis_Homo sapiens_hsa053230.30235313
129GABAergic synapse_Homo sapiens_hsa047270.29897942
130Cholinergic synapse_Homo sapiens_hsa047250.29676272
131Inositol phosphate metabolism_Homo sapiens_hsa005620.29218550
132Glycerophospholipid metabolism_Homo sapiens_hsa005640.28866642
133Phototransduction_Homo sapiens_hsa047440.27216537
134SNARE interactions in vesicular transport_Homo sapiens_hsa041300.26002875
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25062150
136Starch and sucrose metabolism_Homo sapiens_hsa005000.24769998
137Axon guidance_Homo sapiens_hsa043600.24410124
138Measles_Homo sapiens_hsa051620.23179078
139Ras signaling pathway_Homo sapiens_hsa040140.22042322
140Wnt signaling pathway_Homo sapiens_hsa043100.21731754
141Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.21142717
142Mineral absorption_Homo sapiens_hsa049780.20795595
143HIF-1 signaling pathway_Homo sapiens_hsa040660.20529109
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.18918561
145* Adherens junction_Homo sapiens_hsa045200.18678589
146Basal cell carcinoma_Homo sapiens_hsa052170.18088842
147Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.17636592
148Malaria_Homo sapiens_hsa051440.17488862

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