CTNNB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hippo signaling (GO:0035329)4.34103575
2polarized epithelial cell differentiation (GO:0030859)3.89683524
3retina vasculature morphogenesis in camera-type eye (GO:0061299)3.71062230
4paraxial mesoderm development (GO:0048339)3.63266047
5gap junction assembly (GO:0016264)3.59749288
6planar cell polarity pathway involved in neural tube closure (GO:0090179)3.46866710
7bundle of His cell to Purkinje myocyte communication (GO:0086069)3.44776100
8morphogenesis of an epithelial sheet (GO:0002011)3.37608997
9establishment of apical/basal cell polarity (GO:0035089)3.36981139
10desmosome organization (GO:0002934)3.36294625
11insulin-like growth factor receptor signaling pathway (GO:0048009)3.35609598
12regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34905732
13regulation of hippo signaling (GO:0035330)3.33498439
14dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.28076815
15melanin biosynthetic process (GO:0042438)3.20892130
16hemidesmosome assembly (GO:0031581)3.20512485
17glucocorticoid receptor signaling pathway (GO:0042921)3.20023820
18establishment of nucleus localization (GO:0040023)3.18723567
19negative regulation of catenin import into nucleus (GO:0035414)3.15720227
20neuron projection extension involved in neuron projection guidance (GO:1902284)3.15711484
21axon extension involved in axon guidance (GO:0048846)3.15711484
22peptidyl-lysine dimethylation (GO:0018027)3.12335882
23renal system development (GO:0072001)3.10284265
24pore complex assembly (GO:0046931)3.04595759
25regulation of SMAD protein import into nucleus (GO:0060390)2.98554203
26negative regulation of keratinocyte proliferation (GO:0010839)2.98371026
27COPI coating of Golgi vesicle (GO:0048205)2.96738548
28Golgi transport vesicle coating (GO:0048200)2.96738548
29positive regulation of SMAD protein import into nucleus (GO:0060391)2.96363108
30protein retention in ER lumen (GO:0006621)2.95663695
31cell migration involved in sprouting angiogenesis (GO:0002042)2.95043479
32establishment or maintenance of monopolar cell polarity (GO:0061339)2.94876598
33establishment of monopolar cell polarity (GO:0061162)2.94876598
34cytoplasmic mRNA processing body assembly (GO:0033962)2.93902389
35endocardial cushion development (GO:0003197)2.93216803
36* embryonic foregut morphogenesis (GO:0048617)2.92154430
37cell adhesion mediated by integrin (GO:0033627)2.91343306
38pre-miRNA processing (GO:0031054)2.91039305
39glomerular visceral epithelial cell development (GO:0072015)2.88613728
40maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88320798
41regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.88318549
42plasma membrane repair (GO:0001778)2.87656063
43wound healing, spreading of epidermal cells (GO:0035313)2.86866611
44response to lipoprotein particle (GO:0055094)2.85961197
45endothelial cell morphogenesis (GO:0001886)2.85796365
46epithelial cell-cell adhesion (GO:0090136)2.84846093
47COPII vesicle coating (GO:0048208)2.84291317
48establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.82904993
49Notch signaling involved in heart development (GO:0061314)2.76541289
50semaphorin-plexin signaling pathway (GO:0071526)2.74846589
51regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)2.73359691
52respiratory tube development (GO:0030323)2.72949616
53melanin metabolic process (GO:0006582)2.71966318
54positive regulation of hormone biosynthetic process (GO:0046886)2.70783914
55retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.70215746
56renal filtration (GO:0097205)2.67839455
57lymph vessel development (GO:0001945)2.67811660
58regulation of transforming growth factor beta2 production (GO:0032909)2.66204318
59* cell surface receptor signaling pathway involved in heart development (GO:0061311)2.64915799
60regulation of catenin import into nucleus (GO:0035412)2.63938399
61basement membrane organization (GO:0071711)2.63637560
62vascular endothelial growth factor signaling pathway (GO:0038084)2.62259148
63NLS-bearing protein import into nucleus (GO:0006607)2.62125446
64vesicle coating (GO:0006901)2.62098530
65nuclear pore complex assembly (GO:0051292)2.60854799
66glomerular epithelial cell development (GO:0072310)2.60671818
67* gastrulation with mouth forming second (GO:0001702)2.59986032
68* negative regulation of chondrocyte differentiation (GO:0032331)2.58899740
69surfactant homeostasis (GO:0043129)2.58824052
70corticosteroid receptor signaling pathway (GO:0031958)2.57691640
71secondary metabolite biosynthetic process (GO:0044550)2.57084213
72negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)2.55864488
73* adherens junction assembly (GO:0034333)2.55610796
74cell-substrate junction assembly (GO:0007044)2.54930561
75nuclear pore organization (GO:0006999)2.54536794
76collecting duct development (GO:0072044)2.52943671
77cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.52007963
78G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.51867466
79chondrocyte proliferation (GO:0035988)2.50983512
80body morphogenesis (GO:0010171)2.50634354
81blood vessel endothelial cell migration (GO:0043534)2.47771983
82protein localization to endosome (GO:0036010)2.47480016
83heart morphogenesis (GO:0003007)2.47120852
84establishment or maintenance of apical/basal cell polarity (GO:0035088)2.47009180
85establishment or maintenance of bipolar cell polarity (GO:0061245)2.47009180
86outer ear morphogenesis (GO:0042473)2.46912999
87negative regulation of vascular permeability (GO:0043116)2.46526922
88apical protein localization (GO:0045176)2.45601470
89mesodermal cell differentiation (GO:0048333)2.45575814
90* cytoskeletal anchoring at plasma membrane (GO:0007016)2.44918831
91stress fiber assembly (GO:0043149)2.43714682
92ganglion development (GO:0061548)2.43545814
93anatomical structure regression (GO:0060033)2.43429053
94Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.41775782
95* dorsal/ventral axis specification (GO:0009950)2.41266506
96negative regulation of DNA repair (GO:0045738)2.41208381
97membrane protein ectodomain proteolysis (GO:0006509)2.41117457
98establishment of planar polarity (GO:0001736)2.40251501
99establishment of tissue polarity (GO:0007164)2.40251501
100regulation of establishment of planar polarity (GO:0090175)2.39064358
101anterior/posterior axis specification, embryo (GO:0008595)2.38939288
102negative regulation of fatty acid transport (GO:2000192)2.38874137
103cellular protein complex localization (GO:0034629)2.37864974
104ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.36906514
105artery development (GO:0060840)2.36887705
106endodermal cell differentiation (GO:0035987)2.36284738
107asymmetric protein localization (GO:0008105)2.36035073
108lymphangiogenesis (GO:0001946)2.34213088
109non-canonical Wnt signaling pathway (GO:0035567)2.34084825
110notochord development (GO:0030903)2.33806777
111mitotic sister chromatid cohesion (GO:0007064)2.32799722
112regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.32287502
113protein complex localization (GO:0031503)2.31015227
114RNA stabilization (GO:0043489)2.30241669
115mRNA stabilization (GO:0048255)2.30241669
116protein heterotrimerization (GO:0070208)2.30096992
117regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.29191711
118germ cell migration (GO:0008354)2.29166107
119regulation of RNA export from nucleus (GO:0046831)2.28986915
120DNA unwinding involved in DNA replication (GO:0006268)2.26775133
121* adherens junction organization (GO:0034332)2.26535104
122branching involved in salivary gland morphogenesis (GO:0060445)2.25699987
123establishment of epithelial cell polarity (GO:0090162)2.24388866
124cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.23057070
125coronary vasculature morphogenesis (GO:0060977)2.22947056
126cell-substrate adherens junction assembly (GO:0007045)2.22705294
127focal adhesion assembly (GO:0048041)2.22705294
128skin morphogenesis (GO:0043589)2.21821180
129positive regulation of glycogen biosynthetic process (GO:0045725)2.21421249
130regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.20826588
131lateral sprouting from an epithelium (GO:0060601)2.20584871
132positive regulation of nitric-oxide synthase activity (GO:0051000)2.20576928
133receptor catabolic process (GO:0032801)2.20474591
134positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.20271118
135barbed-end actin filament capping (GO:0051016)2.19533780
136negative regulation of anoikis (GO:2000811)2.18656611
137collagen metabolic process (GO:0032963)2.16941135
138ephrin receptor signaling pathway (GO:0048013)2.16496488
139multicellular organismal macromolecule metabolic process (GO:0044259)2.16399354
140mitotic cytokinesis (GO:0000281)2.16037527
141regulation of Rac protein signal transduction (GO:0035020)2.14865330
142convergent extension (GO:0060026)2.07967344
143substrate adhesion-dependent cell spreading (GO:0034446)2.07966606
144axis elongation (GO:0003401)2.07644268
145wound healing, spreading of cells (GO:0044319)2.06779185
146multicellular organismal metabolic process (GO:0044236)2.05688617
147collagen catabolic process (GO:0030574)2.05169982
148regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.04589620
149craniofacial suture morphogenesis (GO:0097094)2.01444118
150peptidyl-proline hydroxylation (GO:0019511)2.01275146
151cell communication by electrical coupling (GO:0010644)2.00962609
152endothelium development (GO:0003158)2.00376954
153ventricular cardiac muscle cell development (GO:0055015)2.00084557
154extracellular matrix disassembly (GO:0022617)1.99329838
155bone remodeling (GO:0046849)1.99260651
156collagen fibril organization (GO:0030199)1.99233452
157regulation of steroid hormone biosynthetic process (GO:0090030)1.98880092
158regulation of keratinocyte proliferation (GO:0010837)1.98591331

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human4.58040139
2* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.58007828
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.40754655
4CLOCK_20551151_ChIP-Seq_293T_Human2.91693103
5FOXM1_23109430_ChIP-Seq_U2OS_Human2.82277282
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.70253053
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.53410020
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.41063796
9WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.38055927
10* TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.37485603
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.24754466
12RBPJ_22232070_ChIP-Seq_NCS_Mouse2.19456262
13* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.16014612
14ZNF263_19887448_ChIP-Seq_K562_Human2.14624425
15* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.10341267
16RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08913258
17SALL4_18804426_ChIP-ChIP_MESCs_Mouse2.07873379
18CDX2_19796622_ChIP-Seq_MESCs_Mouse2.07838664
19ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.99715394
20ESR1_15608294_ChIP-ChIP_MCF-7_Human1.97338104
21* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.93635613
22ZFP281_27345836_Chip-Seq_ESCs_Mouse1.93288371
23KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.92345016
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.90054376
25E2F7_22180533_ChIP-Seq_HELA_Human1.83401464
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.79497180
27HIF1A_21447827_ChIP-Seq_MCF-7_Human1.73322097
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.73015961
29FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.69582855
30P300_27058665_Chip-Seq_ZR-75-30cells_Human1.68393385
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.67650048
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.65923616
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.64312174
34AR_21909140_ChIP-Seq_LNCAP_Human1.63013939
35ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.60888478
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.59715993
37FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.59294098
38WT1_19549856_ChIP-ChIP_CCG9911_Human1.59041590
39* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.58784101
40ESR1_21235772_ChIP-Seq_MCF-7_Human1.57685695
41* ISL1_27105846_Chip-Seq_CPCs_Mouse1.56436015
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.54781084
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.54754869
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.53817203
45* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.50578918
46RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.50493941
47* KDM2B_26808549_Chip-Seq_K562_Human1.49784662
48KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.46655983
49ELK3_25401928_ChIP-Seq_HUVEC_Human1.45583261
50KDM2B_26808549_Chip-Seq_DND41_Human1.45545144
51KDM2B_26808549_Chip-Seq_SUP-B15_Human1.45237597
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.43066954
53CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.41621201
54TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41501127
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.41375152
56NRF2_20460467_ChIP-Seq_MEFs_Mouse1.40177097
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.40177097
58ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.39928632
59* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.38234019
60ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.37752159
61YAP1_20516196_ChIP-Seq_MESCs_Mouse1.37056486
62KDM2B_26808549_Chip-Seq_JURKAT_Human1.36631046
63* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36466455
64* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36466455
65EP300_21415370_ChIP-Seq_HL-1_Mouse1.35399620
66BRD4_25478319_ChIP-Seq_HGPS_Human1.35329567
67ATF3_27146783_Chip-Seq_COLON_Human1.31783489
68PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31704811
69POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.30274770
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.28765112
71SALL4_18804426_ChIP-ChIP_XEN_Mouse1.28051619
72SMAD_19615063_ChIP-ChIP_OVARY_Human1.27984108
73MYC_22102868_ChIP-Seq_BL_Human1.27271530
74TP53_18474530_ChIP-ChIP_U2OS_Human1.26953955
75KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26406554
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.24422981
77RUNX1_27514584_Chip-Seq_MCF-7_Human1.23446187
78TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.23085145
79UBF1/2_26484160_Chip-Seq_HMECs_Human1.22617233
80* TCF7_22412390_ChIP-Seq_EML_Mouse1.21840518
81* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.21063310
82CHD1_26751641_Chip-Seq_LNCaP_Human1.20060203
83CTNNB1_20460455_ChIP-Seq_HCT116_Human1.19888339
84* SOX17_20123909_ChIP-Seq_XEN_Mouse1.19791266
85TCF4_18268006_ChIP-ChIP_LS174T_Human1.19223396
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.18656004
87RACK7_27058665_Chip-Seq_MCF-7_Human1.18444408
88* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.18340253
89SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17766937
90FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.17180709
91OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16999642
92NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16421222
93FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.15896226
94KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.15520737
95AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15162765
96TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14170506
97PKCTHETA_26484144_Chip-Seq_BREAST_Human1.13888847
98TBX3_20139965_ChIP-Seq_MESCs_Mouse1.12206260
99STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.11941359
100TBX3_20139965_ChIP-Seq_ESCs_Mouse1.11792471
101CREB1_26743006_Chip-Seq_LNCaP_Human1.11711489
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11060387
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.11042109
104* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10894118
105* SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.06994869
106AHR_22903824_ChIP-Seq_MCF-7_Human1.06880052
107CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06452306
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.05980767
109GATA6_25053715_ChIP-Seq_YYC3_Human1.05841577
110* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.04927686
111ZFX_18555785_ChIP-Seq_MESCs_Mouse1.03986033
112POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.03884746
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.03455768
114RING1B_27294783_Chip-Seq_NPCs_Mouse1.02861628
115PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.02581845
116UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.02152730
117EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.01097909
118CDX2_20551321_ChIP-Seq_CACO-2_Human1.00635110
119CJUN_26792858_Chip-Seq_BT549_Human1.00051121
120* TBX20_22328084_ChIP-Seq_HEART_Mouse0.99031586
121* TBX20_22080862_ChIP-Seq_HEART_Mouse0.99031586
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98967160
123ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98085168
124FOXM1_26456572_ChIP-Seq_MCF-7_Human0.97492985
125SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97090214
126SOX9_26525672_Chip-Seq_HEART_Mouse0.95743237
127* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.95119418
128TP53_16413492_ChIP-PET_HCT116_Human0.94016759
129SOX2_20726797_ChIP-Seq_SW620_Human0.93887494
130NANOG_16518401_ChIP-PET_MESCs_Mouse0.93398016
131NANOG_16153702_ChIP-ChIP_HESCs_Human0.92392288
132TCF3_18692474_ChIP-Seq_MESCs_Mouse0.92160267
133ARNT_22903824_ChIP-Seq_MCF-7_Human0.91939975
134RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.91476791
135* NELFA_20434984_ChIP-Seq_ESCs_Mouse0.91333525

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.36171911
2MP0005171_absent_coat_pigmentation3.12743213
3MP0004272_abnormal_basement_membrane3.11624992
4MP0009053_abnormal_anal_canal2.67346534
5MP0010352_gastrointestinal_tract_polyps2.63527356
6* MP0000537_abnormal_urethra_morphology2.60962689
7MP0005623_abnormal_meninges_morphology2.48302513
8MP0005076_abnormal_cell_differentiation2.39810161
9MP0003283_abnormal_digestive_organ2.39756994
10MP0003123_paternal_imprinting2.33215130
11MP0010030_abnormal_orbit_morphology2.33182007
12MP0008438_abnormal_cutaneous_collagen2.22376478
13MP0010368_abnormal_lymphatic_system2.11418942
14MP0003122_maternal_imprinting2.09131667
15MP0005409_darkened_coat_color2.03646775
16MP0005275_abnormal_skin_tensile1.96995693
17MP0005408_hypopigmentation1.90589805
18MP0003385_abnormal_body_wall1.85972279
19MP0003566_abnormal_cell_adhesion1.84546260
20MP0003121_genomic_imprinting1.82246956
21MP0000534_abnormal_ureter_morphology1.74993842
22MP0003136_yellow_coat_color1.74283003
23MP0001958_emphysema1.73224408
24MP0001879_abnormal_lymphatic_vessel1.73150923
25MP0000579_abnormal_nail_morphology1.71987368
26MP0002009_preneoplasia1.70432487
27MP0003567_abnormal_fetal_cardiomyocyte1.66287367
28MP0002877_abnormal_melanocyte_morpholog1.64402015
29MP0000428_abnormal_craniofacial_morphol1.64063925
30MP0003942_abnormal_urinary_system1.61690978
31MP0002234_abnormal_pharynx_morphology1.60337450
32* MP0003115_abnormal_respiratory_system1.60186786
33MP0004197_abnormal_fetal_growth/weight/1.58042606
34MP0000569_abnormal_digit_pigmentation1.55322269
35MP0003300_gastrointestinal_ulcer1.53501791
36MP0005503_abnormal_tendon_morphology1.52584413
37* MP0002084_abnormal_developmental_patter1.50359532
38* MP0000733_abnormal_muscle_development1.48273657
39* MP0003119_abnormal_digestive_system1.48215978
40MP0005197_abnormal_uvea_morphology1.45605248
41* MP0003935_abnormal_craniofacial_develop1.44047673
42* MP0010234_abnormal_vibrissa_follicle1.43876194
43MP0000566_synostosis1.40213665
44MP0000516_abnormal_urinary_system1.37927297
45MP0005367_renal/urinary_system_phenotyp1.37927297
46MP0003941_abnormal_skin_development1.36789209
47* MP0002086_abnormal_extraembryonic_tissu1.32085628
48MP0003453_abnormal_keratinocyte_physiol1.31495947
49* MP0001849_ear_inflammation1.30885522
50MP0003890_abnormal_embryonic-extraembry1.29540983
51MP0009780_abnormal_chondrocyte_physiolo1.29400706
52* MP0002896_abnormal_bone_mineralization1.28421475
53* MP0002925_abnormal_cardiovascular_devel1.28199456
54* MP0003937_abnormal_limbs/digits/tail_de1.28124831
55MP0009384_cardiac_valve_regurgitation1.27533419
56* MP0002085_abnormal_embryonic_tissue1.27133154
57MP0004264_abnormal_extraembryonic_tissu1.27081609
58MP0001730_embryonic_growth_arrest1.25443121
59* MP0005187_abnormal_penis_morphology1.24145899
60MP0003091_abnormal_cell_migration1.23028522
61MP0002233_abnormal_nose_morphology1.21824366
62MP0005257_abnormal_intraocular_pressure1.21461680
63MP0000372_irregular_coat_pigmentation1.21307165
64MP0004858_abnormal_nervous_system1.20416439
65MP0003279_aneurysm1.15964030
66MP0009278_abnormal_bone_marrow1.15149110
67MP0002254_reproductive_system_inflammat1.14984675
68* MP0001672_abnormal_embryogenesis/_devel1.14155091
69* MP0005380_embryogenesis_phenotype1.14155091
70* MP0003755_abnormal_palate_morphology1.14153482
71MP0001293_anophthalmia1.13803758
72* MP0002088_abnormal_embryonic_growth/wei1.13164721
73* MP0003984_embryonic_growth_retardation1.12704255
74MP0001299_abnormal_eye_distance/1.12677070
75MP0004233_abnormal_muscle_weight1.12308331
76MP0008932_abnormal_embryonic_tissue1.12099762
77* MP0002060_abnormal_skin_morphology1.11213592
78* MP0010678_abnormal_skin_adnexa1.09450356
79MP0004084_abnormal_cardiac_muscle1.08926211
80MP0000767_abnormal_smooth_muscle1.08619344
81MP0009250_abnormal_appendicular_skeleto1.08347307
82* MP0002697_abnormal_eye_size1.06937531
83MP0010307_abnormal_tumor_latency1.06753560
84MP0000383_abnormal_hair_follicle1.06532569
85MP0005508_abnormal_skeleton_morphology1.06257344
86* MP0000377_abnormal_hair_follicle1.05221769
87MP0000462_abnormal_digestive_system1.04937223
88* MP0001697_abnormal_embryo_size1.04647224
89* MP0002932_abnormal_joint_morphology1.04314398
90MP0004185_abnormal_adipocyte_glucose1.03906976
91* MP0000432_abnormal_head_morphology1.02799915
92* MP0005248_abnormal_Harderian_gland1.00411869
93* MP0002116_abnormal_craniofacial_bone0.98318853
94MP0000013_abnormal_adipose_tissue0.98081361
95* MP0002282_abnormal_trachea_morphology0.98052607
96* MP0002092_abnormal_eye_morphology0.97923830
97MP0002249_abnormal_larynx_morphology0.97805958
98MP0005023_abnormal_wound_healing0.97652242
99MP0009703_decreased_birth_body0.96966628
100MP0008961_abnormal_basal_metabolism0.95693853
101MP0010630_abnormal_cardiac_muscle0.95535437
102MP0000762_abnormal_tongue_morphology0.95472594
103MP0000049_abnormal_middle_ear0.94714033
104MP0009672_abnormal_birth_weight0.93455641
105MP0003950_abnormal_plasma_membrane0.92605033
106MP0000371_diluted_coat_color0.92477755
107* MP0003861_abnormal_nervous_system0.91431787
108MP0004782_abnormal_surfactant_physiolog0.90872046
109MP0006138_congestive_heart_failure0.89810535
110MP0002938_white_spotting0.89455468
111MP0001286_abnormal_eye_development0.89431571
112MP0000751_myopathy0.87706765
113* MP0000266_abnormal_heart_morphology0.87318496
114MP0002089_abnormal_postnatal_growth/wei0.86802004
115MP0001661_extended_life_span0.86532907
116MP0000350_abnormal_cell_proliferation0.85376555
117* MP0002080_prenatal_lethality0.84455016
118* MP0002111_abnormal_tail_morphology0.84229989
119MP0002075_abnormal_coat/hair_pigmentati0.84156647
120* MP0001915_intracranial_hemorrhage0.84079936
121* MP0001614_abnormal_blood_vessel0.83992201
122MP0004270_analgesia0.83050709
123MP0000467_abnormal_esophagus_morphology0.82432407
124MP0001186_pigmentation_phenotype0.82096822
125MP0000003_abnormal_adipose_tissue0.81309526
126* MP0002128_abnormal_blood_circulation0.79986819
127* MP0005193_abnormal_anterior_eye0.78890122
128* MP0000647_abnormal_sebaceous_gland0.77872176
129MP0002177_abnormal_outer_ear0.77449911
130MP0002796_impaired_skin_barrier0.77438321
131* MP0002098_abnormal_vibrissa_morphology0.75134615
132MP0001177_atelectasis0.74408146

Predicted human phenotypes

RankGene SetZ-score
1Shallow orbits (HP:0000586)3.65627435
2Short 4th metacarpal (HP:0010044)3.49813610
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.49813610
4Protrusio acetabuli (HP:0003179)3.14048260
5Cerebral aneurysm (HP:0004944)3.13756330
6Renal duplication (HP:0000075)3.02950816
7Abnormality of the 4th metacarpal (HP:0010012)3.01577068
8Hyperacusis (HP:0010780)2.91832735
9Rectal prolapse (HP:0002035)2.72312945
10Lymphangioma (HP:0100764)2.70764195
11Ankle contracture (HP:0006466)2.64033398
12Bladder diverticulum (HP:0000015)2.63095915
13Hypopigmentation of the fundus (HP:0007894)2.55257750
14Osteolytic defects of the hand bones (HP:0009699)2.54586186
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.54586186
16Enlarged penis (HP:0000040)2.46942094
17Elfin facies (HP:0004428)2.45961294
18Aortic aneurysm (HP:0004942)2.44251039
19Renovascular hypertension (HP:0100817)2.43452024
20Atrophic scars (HP:0001075)2.38947578
21Broad metatarsal (HP:0001783)2.35874008
22Insidious onset (HP:0003587)2.35750939
23Bowel diverticulosis (HP:0005222)2.33654737
24Aplasia involving bones of the extremities (HP:0009825)2.33327115
25Aplasia involving bones of the upper limbs (HP:0009823)2.33327115
26Aplasia of the phalanges of the hand (HP:0009802)2.33327115
27Asymmetry of the thorax (HP:0001555)2.30504342
28Blue irides (HP:0000635)2.30259312
29Deviation of the hallux (HP:0010051)2.29773179
30White forelock (HP:0002211)2.29577700
31Overriding aorta (HP:0002623)2.27575600
32Mitral valve prolapse (HP:0001634)2.26295427
33Premature rupture of membranes (HP:0001788)2.24100533
34Hematochezia (HP:0002573)2.23035247
35Natal tooth (HP:0000695)2.22408145
36Hypoplasia of the iris (HP:0007676)2.21191737
37Buphthalmos (HP:0000557)2.20552108
38Hallux valgus (HP:0001822)2.20222005
39Absent frontal sinuses (HP:0002688)2.16905660
40Vertebral arch anomaly (HP:0008438)2.14051948
41Increased nuchal translucency (HP:0010880)2.13721001
42Flat acetabular roof (HP:0003180)2.12326788
43Pterygium (HP:0001059)2.11202434
44Aneurysm (HP:0002617)2.09746414
45Ankyloglossia (HP:0010296)2.09576187
46Vascular tortuosity (HP:0004948)2.08367965
47Papillary thyroid carcinoma (HP:0002895)2.08163509
48Macroorchidism (HP:0000053)2.07202027
49Arterial tortuosity (HP:0005116)2.06504010
50Cutaneous finger syndactyly (HP:0010554)2.06353104
51Vitreoretinal degeneration (HP:0000655)2.06275077
52Short nail (HP:0001799)2.04593014
53Exostoses (HP:0100777)2.04452873
54Patchy hypopigmentation of hair (HP:0011365)2.04309975
55Abnormality of the distal phalanges of the toes (HP:0010182)2.02373836
56Advanced eruption of teeth (HP:0006288)2.02192154
57Hepatoblastoma (HP:0002884)2.00427845
58Dilatation of the ascending aorta (HP:0005111)1.98604039
59Broad thumb (HP:0011304)1.97511145
60Flat cornea (HP:0007720)1.97383510
61Heterochromia iridis (HP:0001100)1.97311987
62Deviation of the thumb (HP:0009603)1.97109715
63Cutaneous syndactyly (HP:0012725)1.96713815
64Aortic dissection (HP:0002647)1.95774195
65Bronchomalacia (HP:0002780)1.93907762
66Abnormality of the astrocytes (HP:0100707)1.93902917
67Astrocytoma (HP:0009592)1.93902917
68Pointed chin (HP:0000307)1.92761411
69* Subacute progressive viral hepatitis (HP:0006572)1.92024868
70Vertebral clefting (HP:0008428)1.91913011
71Tetraparesis (HP:0002273)1.91780902
72Skull defect (HP:0001362)1.90160830
73Large earlobe (HP:0009748)1.89875926
74Milia (HP:0001056)1.88934314
75Abnormal auditory evoked potentials (HP:0006958)1.87875508
76Insomnia (HP:0100785)1.87564986
77Right ventricular cardiomyopathy (HP:0011663)1.86574263
78Biliary tract neoplasm (HP:0100574)1.84745577
79Colon cancer (HP:0003003)1.83928238
80Proximal placement of thumb (HP:0009623)1.82988275
81Absent eyelashes (HP:0000561)1.81985797
82Abnormality of the distal phalanx of the thumb (HP:0009617)1.81761547
83Turricephaly (HP:0000262)1.81321147
84Ulnar bowing (HP:0003031)1.81119008
85Absent eyebrow (HP:0002223)1.81019843
86Abnormality of the diencephalon (HP:0010662)1.79828356
87Wormian bones (HP:0002645)1.79652735
88Thin bony cortex (HP:0002753)1.78544373
89Abnormality of oral frenula (HP:0000190)1.78431257
90Coronal craniosynostosis (HP:0004440)1.77273749
91Curly hair (HP:0002212)1.77187534
92Mitral stenosis (HP:0001718)1.77037553
93Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.74875516
94Vertebral hypoplasia (HP:0008417)1.74875516
95Fibrous tissue neoplasm (HP:0012316)1.74194754
96Overgrowth (HP:0001548)1.74124127
97Wrist flexion contracture (HP:0001239)1.72705049
98Fibroma (HP:0010614)1.72541625
99Striae distensae (HP:0001065)1.72153942
100Genu recurvatum (HP:0002816)1.72038758
101Radial bowing (HP:0002986)1.71807480
102Short 1st metacarpal (HP:0010034)1.70804769
103Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.70804769
104* Malignant gastrointestinal tract tumors (HP:0006749)1.70114842
105* Gastrointestinal carcinoma (HP:0002672)1.70114842
106Scapular winging (HP:0003691)1.70087520
107Hypoplastic labia majora (HP:0000059)1.69575352
108Hand muscle atrophy (HP:0009130)1.68880010
109High anterior hairline (HP:0009890)1.68222286
110Ependymoma (HP:0002888)1.67498809
111Short humerus (HP:0005792)1.67366537
112Cervical subluxation (HP:0003308)1.65999180
113Short phalanx of the thumb (HP:0009660)1.65948585
114Visceral angiomatosis (HP:0100761)1.65931287
115Omphalocele (HP:0001539)1.65813343
116Obsessive-compulsive behavior (HP:0000722)1.65159840
117Hemangiomatosis (HP:0007461)1.64661623
118Abnormality of dentin (HP:0010299)1.64594316
119Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.64551580
120Wide anterior fontanel (HP:0000260)1.64452402
121Freckling (HP:0001480)1.63962504
122Thick nail (HP:0001805)1.63567092
123Neonatal short-limb short stature (HP:0008921)1.63552342
124Back pain (HP:0003418)1.63487092
125Broad phalanges of the hand (HP:0009768)1.63331072
126Cortical dysplasia (HP:0002539)1.62702805
127Arnold-Chiari malformation (HP:0002308)1.61900436
128Esophageal atresia (HP:0002032)1.61795332
129Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.61512863
130Aplasia/hypoplasia of the humerus (HP:0006507)1.58588112
131Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.58250215
132Distal upper limb amyotrophy (HP:0007149)1.58008326
133Upper limb amyotrophy (HP:0009129)1.58008326
134Scanning speech (HP:0002168)1.57481243
135Broad long bones (HP:0005622)1.57452190
136Broad finger (HP:0001500)1.57099954
137Fragile skin (HP:0001030)1.57055521
138Volvulus (HP:0002580)1.57017031
139Broad ribs (HP:0000885)1.56087030
140Morphological abnormality of the middle ear (HP:0008609)1.55878443
141Missing ribs (HP:0000921)1.55753648
142Vertebral compression fractures (HP:0002953)1.55674227
143Abnormality of the calcaneus (HP:0008364)1.55303051
144Selective tooth agenesis (HP:0001592)1.55235666
145Broad phalanx (HP:0006009)1.54298651
146Long toe (HP:0010511)1.53879984
147Abnormality of the 1st metacarpal (HP:0010009)1.53538551
148Termporal pattern (HP:0011008)1.53289968
149Thyroid carcinoma (HP:0002890)1.52625729
150Neurofibrillary tangles (HP:0002185)1.52093024
151Tracheal stenosis (HP:0002777)1.51762093
152Midface retrusion (HP:0011800)1.50994839
153Deep philtrum (HP:0002002)1.50655157
154Abnormality of the hip-girdle musculature (HP:0001445)1.50468929
155Abnormality of the musculature of the pelvis (HP:0001469)1.50468929
156Aplasia/Hypoplasia of the macula (HP:0008059)1.49979254
157Shoulder girdle muscle weakness (HP:0003547)1.49975590
158Rhizomelia (HP:0008905)1.48418476
159Relative macrocephaly (HP:0004482)1.47210364
160Hammertoe (HP:0001765)1.47046680
161Thin ribs (HP:0000883)1.45884296
162Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.45098556
163Cerebral inclusion bodies (HP:0100314)1.44863515
164Broad face (HP:0000283)1.42648676
165Alacrima (HP:0000522)1.42590323

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB33.91136882
2PKN23.68262557
3LATS13.22129064
4RIPK12.96398220
5PDGFRA2.79241934
6BCR2.70076666
7EPHB22.54769730
8EEF2K2.27300937
9DDR22.25759705
10SCYL22.21533445
11MAP3K102.20676525
12SRPK12.16711082
13TTN2.10294526
14NEK12.01029677
15EPHA21.85693167
16LATS21.84056876
17TIE11.78750661
18CDK121.76010204
19TGFBR11.63320063
20PLK21.55514594
21SMG11.55047412
22* PTK61.54837127
23LMTK21.53733990
24KSR11.49373547
25WEE11.49337577
26PTK21.48466494
27TYRO31.46368296
28LRRK21.45846031
29FGFR21.44494296
30PRKD31.43991982
31KSR21.43868141
32MKNK21.41263468
33MET1.38741479
34STK241.36343061
35FGFR11.34403451
36TRIM281.32176829
37MAP3K21.32012806
38PASK1.31350279
39ERBB41.26761259
40SIK11.26681068
41ERBB31.24092624
42STK31.23308245
43PDGFRB1.21947044
44BMX1.21135354
45RET1.19708176
46MTOR1.18740437
47RPS6KB21.18596470
48FRK1.16929842
49ICK1.14362090
50TSSK61.13774981
51ALK1.12595088
52PAK21.12218431
53NEK21.08473644
54MAP3K91.03590534
55PBK1.01908844
56CDC71.00327884
57DMPK0.97181382
58PAK30.94871776
59TGFBR20.94849811
60MST1R0.94459133
61STK390.91719186
62CAMK1D0.90815135
63MOS0.89792694
64CAMK1G0.86996091
65MAP3K80.84274708
66EPHA40.83805518
67TAF10.83691159
68EIF2AK30.83074005
69AKT30.82274934
70DYRK1B0.79614509
71CAMKK10.78848045
72CASK0.78537110
73PAK60.77697427
74MST40.75305245
75TNIK0.73801082
76TESK10.73640284
77SIK30.72858223
78STK38L0.72118445
79ILK0.71971670
80FGFR30.71613183
81EPHB10.66498637
82BRSK20.66456781
83KDR0.66327215
84STK100.66075441
85NTRK10.64627650
86MAP2K10.62921558
87NEK60.61492766
88CDK180.60700358
89MELK0.60601200
90RPS6KA40.57485274
91* FER0.57042092
92ROCK10.56183106
93YES10.55355171
94MAP2K20.53882959
95MAP2K70.52944600
96MAP3K40.52494985
97CDK140.51239190
98TTK0.49447221
99CDK150.49355580
100BRD40.49254734
101EPHA30.48384606
102CDC42BPA0.47150903
103CDK70.46651399
104MARK10.46479065
105PTK2B0.45074931
106PRKCH0.44791024
107* PAK40.43579076
108STK380.43362455
109RPS6KA20.42732876
110LIMK10.40867938
111* SRC0.40850826
112MKNK10.40415356
113NTRK20.38863545
114CDK11A0.38837713
115ERN10.38050015
116PLK30.37735140
117CDK40.37342817
118TAOK10.37092272
119MAPK100.36832755
120MAP3K70.36744552
121* ERBB20.36317272
122AURKB0.36069502
123FGFR40.35842068
124IRAK30.35586338
125MAP3K60.35186243
126RPS6KB10.33606016
127PRKCE0.33585060
128PRKDC0.32996196
129FLT30.32807781
130ROCK20.32551325
131CHEK10.32477031
132EIF2AK20.32410402
133WNK30.32178877
134PRKG20.31908595
135MINK10.31768556
136NEK90.31318895
137INSR0.31313770
138NLK0.31188764
139RPS6KA10.30675394
140CDK90.29603305

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid biosynthesis_Homo sapiens_hsa001002.31711546
2* Adherens junction_Homo sapiens_hsa045202.26174725
3* Hippo signaling pathway_Homo sapiens_hsa043902.16589421
4ECM-receptor interaction_Homo sapiens_hsa045122.14776646
5* Focal adhesion_Homo sapiens_hsa045101.97352736
6* Proteoglycans in cancer_Homo sapiens_hsa052051.89812722
7* Basal cell carcinoma_Homo sapiens_hsa052171.84700439
8Small cell lung cancer_Homo sapiens_hsa052221.77105962
9Chronic myeloid leukemia_Homo sapiens_hsa052201.72201987
10MicroRNAs in cancer_Homo sapiens_hsa052061.70252676
11* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.69801392
12* Tight junction_Homo sapiens_hsa045301.66523551
13Hedgehog signaling pathway_Homo sapiens_hsa043401.65748744
14TGF-beta signaling pathway_Homo sapiens_hsa043501.62321339
15* Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.53283746
16mTOR signaling pathway_Homo sapiens_hsa041501.51977256
17Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.51354002
18Vitamin B6 metabolism_Homo sapiens_hsa007501.47141977
19Bladder cancer_Homo sapiens_hsa052191.46432137
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.45453241
21* Endometrial cancer_Homo sapiens_hsa052131.45416856
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.43563277
23Glioma_Homo sapiens_hsa052141.42374263
24Axon guidance_Homo sapiens_hsa043601.39262653
25Central carbon metabolism in cancer_Homo sapiens_hsa052301.37119092
26Nitrogen metabolism_Homo sapiens_hsa009101.36777203
27Biosynthesis of amino acids_Homo sapiens_hsa012301.34626378
28Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.34509708
29Estrogen signaling pathway_Homo sapiens_hsa049151.32557314
30Amoebiasis_Homo sapiens_hsa051461.31248393
31* Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.30786654
32Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.28996714
33Dorso-ventral axis formation_Homo sapiens_hsa043201.28995881
34* Colorectal cancer_Homo sapiens_hsa052101.28247949
35Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.27421190
36Renal cell carcinoma_Homo sapiens_hsa052111.27038140
37AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.25406401
38Protein digestion and absorption_Homo sapiens_hsa049741.25392482
39Glycosaminoglycan degradation_Homo sapiens_hsa005311.21301511
40Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.20701392
41* Melanogenesis_Homo sapiens_hsa049161.20127859
42Gap junction_Homo sapiens_hsa045401.19634523
43Notch signaling pathway_Homo sapiens_hsa043301.16389841
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.16329782
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15691110
46Other glycan degradation_Homo sapiens_hsa005111.15291930
47Pancreatic cancer_Homo sapiens_hsa052121.14184699
48Dilated cardiomyopathy_Homo sapiens_hsa054141.14152630
49* Wnt signaling pathway_Homo sapiens_hsa043101.13584486
50* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10652183
51Non-small cell lung cancer_Homo sapiens_hsa052231.10373679
52Viral myocarditis_Homo sapiens_hsa054161.07525479
53* Leukocyte transendothelial migration_Homo sapiens_hsa046701.06957224
54VEGF signaling pathway_Homo sapiens_hsa043701.06261041
55Vibrio cholerae infection_Homo sapiens_hsa051101.05949813
56Neurotrophin signaling pathway_Homo sapiens_hsa047221.04242134
57Oocyte meiosis_Homo sapiens_hsa041141.04177990
58* Rap1 signaling pathway_Homo sapiens_hsa040151.02991789
59Pentose phosphate pathway_Homo sapiens_hsa000301.02840406
60* Pathways in cancer_Homo sapiens_hsa052001.02710372
61Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02495442
622-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.99939041
63Carbon metabolism_Homo sapiens_hsa012000.97207046
64Insulin resistance_Homo sapiens_hsa049310.97183833
65Melanoma_Homo sapiens_hsa052180.93475850
66Lysine degradation_Homo sapiens_hsa003100.92141994
67Regulation of actin cytoskeleton_Homo sapiens_hsa048100.91384566
68Non-homologous end-joining_Homo sapiens_hsa034500.91120160
69Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90594859
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.90542532
71Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.89996004
72PI3K-Akt signaling pathway_Homo sapiens_hsa041510.88901596
73Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.88602563
74Sphingolipid metabolism_Homo sapiens_hsa006000.88413998
75* Prostate cancer_Homo sapiens_hsa052150.87649471
76Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86718004
77Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.84840408
78Platelet activation_Homo sapiens_hsa046110.84553201
79AMPK signaling pathway_Homo sapiens_hsa041520.82702582
80* HTLV-I infection_Homo sapiens_hsa051660.82334363
81Type II diabetes mellitus_Homo sapiens_hsa049300.82276592
82Viral carcinogenesis_Homo sapiens_hsa052030.82152308
83p53 signaling pathway_Homo sapiens_hsa041150.80896222
84Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.80438603
85Thyroid hormone synthesis_Homo sapiens_hsa049180.80093357
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.79538642
87Galactose metabolism_Homo sapiens_hsa000520.79507351
88Cell cycle_Homo sapiens_hsa041100.79448863
89ErbB signaling pathway_Homo sapiens_hsa040120.78473032
90Gastric acid secretion_Homo sapiens_hsa049710.76978463
91Insulin signaling pathway_Homo sapiens_hsa049100.76646393
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76498430
93GnRH signaling pathway_Homo sapiens_hsa049120.76369924
94HIF-1 signaling pathway_Homo sapiens_hsa040660.74652990
95Renin-angiotensin system_Homo sapiens_hsa046140.74614123
96mRNA surveillance pathway_Homo sapiens_hsa030150.74441522
97Toxoplasmosis_Homo sapiens_hsa051450.73955760
98Inositol phosphate metabolism_Homo sapiens_hsa005620.73362580
99Renin secretion_Homo sapiens_hsa049240.72976540
100Arginine biosynthesis_Homo sapiens_hsa002200.72034831
101* Thyroid cancer_Homo sapiens_hsa052160.71544439
102Fatty acid metabolism_Homo sapiens_hsa012120.71233218
103FoxO signaling pathway_Homo sapiens_hsa040680.70206238
104Long-term potentiation_Homo sapiens_hsa047200.68221008
105Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65632974
106Phospholipase D signaling pathway_Homo sapiens_hsa040720.65512043
107Endocytosis_Homo sapiens_hsa041440.65307726
108Lysosome_Homo sapiens_hsa041420.65059106
109Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64801470
110* Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64188855
111Glucagon signaling pathway_Homo sapiens_hsa049220.64046020
112Aldosterone synthesis and secretion_Homo sapiens_hsa049250.64025828
113Prolactin signaling pathway_Homo sapiens_hsa049170.63906548
114Bile secretion_Homo sapiens_hsa049760.63529071
115Prion diseases_Homo sapiens_hsa050200.63228311
116Salmonella infection_Homo sapiens_hsa051320.62817734
117Alcoholism_Homo sapiens_hsa050340.62128163
118Carbohydrate digestion and absorption_Homo sapiens_hsa049730.60698963
119Oxytocin signaling pathway_Homo sapiens_hsa049210.59271635
120Fructose and mannose metabolism_Homo sapiens_hsa000510.58955529
121Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58901852
122Circadian rhythm_Homo sapiens_hsa047100.58745400
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58537025
124Shigellosis_Homo sapiens_hsa051310.58516700
125Transcriptional misregulation in cancer_Homo sapiens_hsa052020.57601503
126Fatty acid elongation_Homo sapiens_hsa000620.56985010
127Pyruvate metabolism_Homo sapiens_hsa006200.56598660
128Arginine and proline metabolism_Homo sapiens_hsa003300.56189085
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.55723000
130Choline metabolism in cancer_Homo sapiens_hsa052310.52591515
131N-Glycan biosynthesis_Homo sapiens_hsa005100.51778187
132Mineral absorption_Homo sapiens_hsa049780.50974513
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.49831312
134Insulin secretion_Homo sapiens_hsa049110.48663524
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.47068042
136Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.44144913

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