CTNNBIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene binds CTNNB1 and prevents interaction between CTNNB1 and TCF family members. The encoded protein is a negative regulator of the Wnt signaling pathway. Two transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1keratinization (GO:0031424)7.32634048
2establishment of skin barrier (GO:0061436)7.04307282
3regulation of water loss via skin (GO:0033561)6.21486889
4desmosome organization (GO:0002934)6.18301490
5axon ensheathment in central nervous system (GO:0032291)4.96374278
6central nervous system myelination (GO:0022010)4.96374278
7positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.50941375
8keratinocyte proliferation (GO:0043616)4.22902596
9adenine nucleotide transport (GO:0051503)4.13492356
10layer formation in cerebral cortex (GO:0021819)4.13337703
11keratinocyte differentiation (GO:0030216)4.04651481
12multicellular organismal water homeostasis (GO:0050891)4.01603019
13dendritic spine morphogenesis (GO:0060997)3.99258158
14gap junction assembly (GO:0016264)3.96100301
15establishment of mitochondrion localization (GO:0051654)3.91988854
16planar cell polarity pathway involved in neural tube closure (GO:0090179)3.80228740
17regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.67549786
18lateral sprouting from an epithelium (GO:0060601)3.60462582
19neuron recognition (GO:0008038)3.56196500
20establishment of planar polarity (GO:0001736)3.55446408
21establishment of tissue polarity (GO:0007164)3.55446408
22cell migration in hindbrain (GO:0021535)3.54316455
23pyrimidine nucleobase catabolic process (GO:0006208)3.50263209
24negative regulation of microtubule polymerization (GO:0031115)3.49956367
25regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.47987938
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.43232742
27axon extension involved in axon guidance (GO:0048846)3.43232742
28axonal fasciculation (GO:0007413)3.42919731
29positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.41855424
30purine ribonucleotide transport (GO:0015868)3.36971339
31cell communication by electrical coupling (GO:0010644)3.30830574
32intermediate filament organization (GO:0045109)3.30227757
33water homeostasis (GO:0030104)3.29241941
34neuron cell-cell adhesion (GO:0007158)3.28136142
35epidermal cell differentiation (GO:0009913)3.27888427
36purine nucleotide transport (GO:0015865)3.24600630
37regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.22649804
38mitochondrion transport along microtubule (GO:0047497)3.21887959
39establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.21887959
40synaptic vesicle maturation (GO:0016188)3.18839558
41dopamine receptor signaling pathway (GO:0007212)3.17392621
42limb bud formation (GO:0060174)3.16706966
43chemical homeostasis within a tissue (GO:0048875)3.13628144
44hair cycle (GO:0042633)3.10966573
45molting cycle (GO:0042303)3.10966573
46surfactant homeostasis (GO:0043129)3.07355553
47dendrite morphogenesis (GO:0048813)3.06888084
48cerebral cortex radially oriented cell migration (GO:0021799)3.06511027
49epidermis development (GO:0008544)3.01458623
50peptide cross-linking (GO:0018149)3.01052007
51epithelial cell differentiation involved in prostate gland development (GO:0060742)2.92039919
52ephrin receptor signaling pathway (GO:0048013)2.91528232
53synaptic vesicle exocytosis (GO:0016079)2.90869704
54mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.90783766
55G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.90094606
56linoleic acid metabolic process (GO:0043651)2.89447172
57fatty acid elongation (GO:0030497)2.86270429
58energy coupled proton transport, down electrochemical gradient (GO:0015985)2.85609230
59ATP synthesis coupled proton transport (GO:0015986)2.85609230
60positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.85477612
61establishment of nucleus localization (GO:0040023)2.85463721
62regulation of penile erection (GO:0060405)2.82883337
63long-chain fatty acid biosynthetic process (GO:0042759)2.81393142
64ensheathment of neurons (GO:0007272)2.79837308
65axon ensheathment (GO:0008366)2.79837308
66camera-type eye morphogenesis (GO:0048593)2.79761566
67myelination (GO:0042552)2.78592558
68Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.77964543
69specification of organ identity (GO:0010092)2.77534194
70hemidesmosome assembly (GO:0031581)2.77204240
71atrial cardiac muscle cell action potential (GO:0086014)2.76885648
72regulation of synapse structural plasticity (GO:0051823)2.74065165
73bundle of His cell to Purkinje myocyte communication (GO:0086069)2.73015607
74negative regulation of axon extension involved in axon guidance (GO:0048843)2.72737747
75calcium-mediated signaling using intracellular calcium source (GO:0035584)2.69985069
76negative regulation of catenin import into nucleus (GO:0035414)2.69202945
77regulation of synaptic vesicle exocytosis (GO:2000300)2.68232056
78dendritic spine organization (GO:0097061)2.67485546
79negative regulation of axon extension (GO:0030517)2.67000110
80apical protein localization (GO:0045176)2.65387710
81negative regulation of protein localization to cell surface (GO:2000009)2.64810021
82chemosensory behavior (GO:0007635)2.62947948
83regulation of establishment of planar polarity (GO:0090175)2.62785977
84astrocyte differentiation (GO:0048708)2.62706206
85viral transcription (GO:0019083)2.61447030
86nucleobase catabolic process (GO:0046113)2.60888493
87detection of temperature stimulus involved in sensory perception (GO:0050961)2.60573020
88detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.60573020
89glutamate secretion (GO:0014047)2.58656922
90retinal ganglion cell axon guidance (GO:0031290)2.57450793
91regulation of glomerular filtration (GO:0003093)2.56441618
92organelle transport along microtubule (GO:0072384)2.56271772
93endothelium development (GO:0003158)2.56104918
94negative regulation of axonogenesis (GO:0050771)2.55961237
95cell communication involved in cardiac conduction (GO:0086065)2.52987548
96adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.52861484
97substantia nigra development (GO:0021762)2.52813630
98behavioral response to cocaine (GO:0048148)2.52035072
99non-canonical Wnt signaling pathway (GO:0035567)2.51073373
100establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.50674338
101body morphogenesis (GO:0010171)2.50067926
102axon cargo transport (GO:0008088)2.48738268
103lens fiber cell development (GO:0070307)2.48534645
104regulation of axon extension involved in axon guidance (GO:0048841)2.47056091
105protein localization to synapse (GO:0035418)2.46265433
106central nervous system projection neuron axonogenesis (GO:0021952)2.45987708
107vocalization behavior (GO:0071625)2.45885890
108negative regulation of heart growth (GO:0061117)2.44289625
109negative regulation of cardiac muscle tissue growth (GO:0055022)2.44289625
110convergent extension (GO:0060026)2.44248785
111paraxial mesoderm development (GO:0048339)2.44062697
112cardiac muscle cell action potential involved in contraction (GO:0086002)2.42592663
113cerebellar Purkinje cell layer development (GO:0021680)2.41816552
114translational termination (GO:0006415)2.40458312
115negative regulation of axon guidance (GO:1902668)2.40249443
116mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.39267041
117neuronal action potential propagation (GO:0019227)2.38025005
118negative regulation of neurotransmitter transport (GO:0051589)2.37292939
119ventricular cardiac muscle cell action potential (GO:0086005)2.37192965
120axon extension (GO:0048675)2.36862473
121intermediate filament cytoskeleton organization (GO:0045104)2.35878282
122photoreceptor cell differentiation (GO:0046530)2.35188500
123eye photoreceptor cell differentiation (GO:0001754)2.35188500
124regulation of short-term neuronal synaptic plasticity (GO:0048172)2.35022661
125myelination in peripheral nervous system (GO:0022011)2.34571558
126peripheral nervous system axon ensheathment (GO:0032292)2.34571558
127cardiac muscle cell action potential (GO:0086001)2.33896488
128substrate-independent telencephalic tangential migration (GO:0021826)2.32829596
129substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.32829596
130regulation of extent of cell growth (GO:0061387)2.32688489
131positive regulation of synapse assembly (GO:0051965)2.32004889
132regulation of axon extension (GO:0030516)2.31315950
133keratinocyte development (GO:0003334)2.30225772
134regulation of axon guidance (GO:1902667)2.29055619
135regulation of microtubule polymerization (GO:0031113)2.28775614
136regulation of membrane repolarization (GO:0060306)2.28449889
137locomotory exploration behavior (GO:0035641)2.28175695
138myelin maintenance (GO:0043217)2.28077856
139enteric nervous system development (GO:0048484)2.26857325
140regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.26745919
141presynaptic membrane organization (GO:0097090)2.26146693
142plasma membrane repair (GO:0001778)2.26068659
143regulation of collateral sprouting (GO:0048670)2.24981592
144cholesterol biosynthetic process (GO:0006695)2.24361057
145hippocampus development (GO:0021766)2.22232992
146positive regulation of potassium ion transmembrane transport (GO:1901381)2.22224560
147polarized epithelial cell differentiation (GO:0030859)2.20846828
148asymmetric protein localization (GO:0008105)2.20677852
149detection of temperature stimulus (GO:0016048)2.20529887
150regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.19932800
151positive regulation of axon extension (GO:0045773)2.19515351
152positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.19514708
153neuronal ion channel clustering (GO:0045161)2.19339110
154regulation of synaptic vesicle transport (GO:1902803)2.18796056
155neuron fate determination (GO:0048664)2.18301828
156cell-cell junction maintenance (GO:0045217)2.17446640
157activation of protein kinase A activity (GO:0034199)2.17304527
158neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.17207859
159regulation of axonogenesis (GO:0050770)2.16676312
160cerebral cortex neuron differentiation (GO:0021895)2.16354211
161postsynaptic membrane organization (GO:0001941)2.16094803
162neuron projection extension (GO:1990138)2.16051865
163short-term memory (GO:0007614)2.15226967
164cranial nerve development (GO:0021545)2.14666699
165membrane repolarization (GO:0086009)2.12867243
166regulation of neuronal synaptic plasticity (GO:0048168)2.12665065
167exploration behavior (GO:0035640)2.11822080
168auditory behavior (GO:0031223)2.11591964
169synapse organization (GO:0050808)2.11394561
170neurofilament cytoskeleton organization (GO:0060052)2.11300696
171peptidyl-tyrosine autophosphorylation (GO:0038083)2.10845529

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.22042412
2EZH2_27304074_Chip-Seq_ESCs_Mouse2.93164956
3JARID2_20064375_ChIP-Seq_MESCs_Mouse2.87439885
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.77648144
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.74502243
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70278402
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70278402
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67221915
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.56551199
10SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.54772175
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.49227845
12EZH2_27294783_Chip-Seq_ESCs_Mouse2.39042463
13SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.34281197
14SUZ12_27294783_Chip-Seq_ESCs_Mouse2.32334774
15MTF2_20144788_ChIP-Seq_MESCs_Mouse2.29136268
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.28549070
17RNF2_27304074_Chip-Seq_ESCs_Mouse2.18220765
18TRIM28_21343339_ChIP-Seq_HEK293_Human2.13948838
19STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99730931
20PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.97909169
21NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90930474
22THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.80113976
23GBX2_23144817_ChIP-Seq_PC3_Human1.79805739
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79686609
25CBX2_27304074_Chip-Seq_ESCs_Mouse1.76709064
26RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.73333419
27BMI1_23680149_ChIP-Seq_NPCS_Mouse1.68931626
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.66679793
29LXR_22292898_ChIP-Seq_THP-1_Human1.63506921
30AR_21572438_ChIP-Seq_LNCaP_Human1.61944388
31SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61176342
32* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.57205010
33RING1B_27294783_Chip-Seq_ESCs_Mouse1.56978312
34REST_21632747_ChIP-Seq_MESCs_Mouse1.55759991
35ERG_21242973_ChIP-ChIP_JURKAT_Human1.54398543
36RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.54183651
37RING1B_27294783_Chip-Seq_NPCs_Mouse1.53715180
38P63_26484246_Chip-Seq_KERATINOCYTES_Human1.52062771
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.51073386
40UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.46855523
41ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.44685901
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.44487997
43ZFP281_27345836_Chip-Seq_ESCs_Mouse1.43943526
44EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42915054
45OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.42152133
46ZNF263_19887448_ChIP-Seq_K562_Human1.41899690
47WT1_19549856_ChIP-ChIP_CCG9911_Human1.41124065
48RARG_19884340_ChIP-ChIP_MEFs_Mouse1.40522276
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.40427568
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.39866724
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39041994
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.37416965
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37319720
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.37115246
55DROSHA_22980978_ChIP-Seq_HELA_Human1.36473372
56ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.30979809
57TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30844700
58ZFP281_18757296_ChIP-ChIP_E14_Mouse1.30578223
59RBPJ_22232070_ChIP-Seq_NCS_Mouse1.28841424
60SOX9_24532713_ChIP-Seq_HFSC_Mouse1.28508988
61RACK7_27058665_Chip-Seq_MCF-7_Human1.27269213
62RNF2_27304074_Chip-Seq_NSC_Mouse1.24391161
63KDM2B_26808549_Chip-Seq_JURKAT_Human1.24003911
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.23231413
65SMC4_20622854_ChIP-Seq_HELA_Human1.22902062
66OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21836808
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20433638
68* KDM2B_26808549_Chip-Seq_K562_Human1.20389085
69CREB1_26743006_Chip-Seq_LNCaP_Human1.20135958
70* TP63_22573176_ChIP-Seq_HFKS_Human1.18428012
71* KDM2B_26808549_Chip-Seq_DND41_Human1.18335847
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.17891382
73PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.17808701
74ZNF274_21170338_ChIP-Seq_K562_Hela1.15960816
75CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.14647648
76P68_20966046_ChIP-Seq_HELA_Human1.13677795
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12772736
78TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12594109
79WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12228356
80CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.11242991
81ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09957432
82NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.09910473
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.06645748
84* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.06415030
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05932629
86VDR_22108803_ChIP-Seq_LS180_Human1.04999510
87SMAD3_21741376_ChIP-Seq_EPCs_Human1.04926621
88ESR2_21235772_ChIP-Seq_MCF-7_Human1.04681512
89TOP2B_26459242_ChIP-Seq_MCF-7_Human1.04662556
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04183366
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04164777
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.03700367
93TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.03537506
94* SA1_27219007_Chip-Seq_ERYTHROID_Human1.03180737
95SOX3_22085726_ChIP-Seq_NPCs_Mouse1.01838459
96* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01125968
97* CTCF_27219007_Chip-Seq_Bcells_Human1.00805905
98* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.00720082
99NFIB_24661679_ChIP-Seq_LUNG_Mouse1.00176697
100STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99878350
101PIAS1_25552417_ChIP-Seq_VCAP_Human0.99518258
102IGF1R_20145208_ChIP-Seq_DFB_Human0.99021014
103TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98521482
104AHR_22903824_ChIP-Seq_MCF-7_Human0.97073326
105* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96912744
106ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.95400722
107DNAJC2_21179169_ChIP-ChIP_NT2_Human0.94393566
108ZFP57_27257070_Chip-Seq_ESCs_Mouse0.93475448
109P300_27058665_Chip-Seq_ZR-75-30cells_Human0.93018739
110* ELK3_25401928_ChIP-Seq_HUVEC_Human0.92649785
111RXR_22108803_ChIP-Seq_LS180_Human0.92131653
112SOX2_21211035_ChIP-Seq_LN229_Gbm0.91178756
113* CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.90723673
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.90336346
115PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90018497
116PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.88577208
117RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.87943562
118ARNT_22903824_ChIP-Seq_MCF-7_Human0.87728379
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.87313126
120ISL1_27105846_Chip-Seq_CPCs_Mouse0.87274896
121P300_19829295_ChIP-Seq_ESCs_Human0.86240784
122SMAD4_21741376_ChIP-Seq_HESCs_Human0.85166780
123* TP53_23651856_ChIP-Seq_MEFs_Mouse0.83460905
124ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83102898
125TAF15_26573619_Chip-Seq_HEK293_Human0.83032152
126TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.82491105
127POU5F1_16153702_ChIP-ChIP_HESCs_Human0.82366867
128GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.82358440
129CLOCK_20551151_ChIP-Seq_293T_Human0.82356604
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82146360
131PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.81304710
132* RUNX1_27514584_Chip-Seq_MCF-7_Human0.81243473
133SMAD4_21799915_ChIP-Seq_A2780_Human0.81136962
134P53_22127205_ChIP-Seq_FIBROBLAST_Human0.80879956
135YAP1_20516196_ChIP-Seq_MESCs_Mouse0.80061366
136MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79849569
137LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.79610309
138TP53_18474530_ChIP-ChIP_U2OS_Human0.78771359
139PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.77762199
140SMAD3_21741376_ChIP-Seq_ESCs_Human0.77314860
141* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.76668274
142AR_19668381_ChIP-Seq_PC3_Human0.76494565
143TET1_21490601_ChIP-Seq_MESCs_Mouse0.75154561
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.74294058

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000566_synostosis5.39947714
2MP0004270_analgesia2.95579620
3MP0005501_abnormal_skin_physiology2.82763860
4MP0010234_abnormal_vibrissa_follicle2.75107798
5MP0004859_abnormal_synaptic_plasticity2.62606075
6MP0003880_abnormal_central_pattern2.60102544
7MP0000778_abnormal_nervous_system2.58399786
8MP0003123_paternal_imprinting2.42800379
9MP0002734_abnormal_mechanical_nocicepti1.99593229
10MP0002837_dystrophic_cardiac_calcinosis1.99394027
11MP0004858_abnormal_nervous_system1.98003285
12MP0005499_abnormal_olfactory_system1.95015345
13MP0005394_taste/olfaction_phenotype1.95015345
14MP0003635_abnormal_synaptic_transmissio1.94760605
15MP0003453_abnormal_keratinocyte_physiol1.91556500
16MP0006276_abnormal_autonomic_nervous1.88275278
17MP0009780_abnormal_chondrocyte_physiolo1.85156352
18MP0005423_abnormal_somatic_nervous1.82707420
19MP0005623_abnormal_meninges_morphology1.78176111
20MP0000751_myopathy1.68827652
21MP0004272_abnormal_basement_membrane1.67173571
22MP0005409_darkened_coat_color1.66263037
23MP0002733_abnormal_thermal_nociception1.66129001
24MP0003329_amyloid_beta_deposits1.63946482
25MP0002184_abnormal_innervation1.63543519
26MP0001299_abnormal_eye_distance/1.58343963
27MP0003122_maternal_imprinting1.57934637
28MP0004782_abnormal_surfactant_physiolog1.56971121
29MP0000955_abnormal_spinal_cord1.56576219
30MP0002063_abnormal_learning/memory/cond1.54256209
31MP0001968_abnormal_touch/_nociception1.51846133
32MP0003705_abnormal_hypodermis_morpholog1.51153533
33MP0000920_abnormal_myelination1.50462213
34MP0001486_abnormal_startle_reflex1.45298694
35MP0002064_seizures1.42033237
36MP0009379_abnormal_foot_pigmentation1.40348609
37MP0005377_hearing/vestibular/ear_phenot1.39791933
38MP0003878_abnormal_ear_physiology1.39791933
39MP0002735_abnormal_chemical_nociception1.39100064
40MP0006072_abnormal_retinal_apoptosis1.37489741
41MP0001529_abnormal_vocalization1.37456039
42MP0002272_abnormal_nervous_system1.37073182
43MP0010771_integument_phenotype1.36126044
44MP0003634_abnormal_glial_cell1.35810032
45MP0001216_abnormal_epidermal_layer1.35734218
46MP0001970_abnormal_pain_threshold1.35625994
47MP0002653_abnormal_ependyma_morphology1.35197643
48MP0002882_abnormal_neuron_morphology1.34828660
49MP0002098_abnormal_vibrissa_morphology1.33138595
50MP0010678_abnormal_skin_adnexa1.31271120
51MP0003283_abnormal_digestive_organ1.29389067
52MP0003941_abnormal_skin_development1.28330168
53MP0000383_abnormal_hair_follicle1.27644628
54MP0006292_abnormal_olfactory_placode1.27114687
55MP0003137_abnormal_impulse_conducting1.26987378
56MP0001440_abnormal_grooming_behavior1.26501141
57MP0004885_abnormal_endolymph1.25096659
58MP0000579_abnormal_nail_morphology1.25059482
59MP0010030_abnormal_orbit_morphology1.21492024
60MP0009745_abnormal_behavioral_response1.19616710
61MP0002572_abnormal_emotion/affect_behav1.18784986
62MP0000537_abnormal_urethra_morphology1.18751948
63MP0004811_abnormal_neuron_physiology1.18554549
64MP0002638_abnormal_pupillary_reflex1.17975081
65MP0002796_impaired_skin_barrier1.17963553
66MP0003385_abnormal_body_wall1.17692897
67* MP0002233_abnormal_nose_morphology1.17383835
68MP0002249_abnormal_larynx_morphology1.15808016
69MP0009250_abnormal_appendicular_skeleto1.14257002
70MP0002909_abnormal_adrenal_gland1.13795738
71MP0004215_abnormal_myocardial_fiber1.11874557
72MP0005187_abnormal_penis_morphology1.11837994
73MP0000750_abnormal_muscle_regeneration1.11761735
74MP0001905_abnormal_dopamine_level1.11745645
75MP0000428_abnormal_craniofacial_morphol1.11382507
76MP0002557_abnormal_social/conspecific_i1.11342037
77MP0002822_catalepsy1.10363954
78MP0003121_genomic_imprinting1.10316378
79MP0002752_abnormal_somatic_nervous1.08774601
80MP0002234_abnormal_pharynx_morphology1.08515071
81MP0003315_abnormal_perineum_morphology1.07997490
82MP0000631_abnormal_neuroendocrine_gland1.07428323
83MP0002751_abnormal_autonomic_nervous1.07216534
84MP0005257_abnormal_intraocular_pressure1.07187513
85MP0002067_abnormal_sensory_capabilities1.06995546
86MP0004381_abnormal_hair_follicle1.06901361
87MP0002736_abnormal_nociception_after1.06556549
88* MP0002152_abnormal_brain_morphology1.06099479
89MP0005248_abnormal_Harderian_gland1.05967445
90MP0000049_abnormal_middle_ear1.04466737
91MP0004742_abnormal_vestibular_system1.04163899
92MP0004233_abnormal_muscle_weight1.03382665
93* MP0003861_abnormal_nervous_system1.02048650
94MP0004145_abnormal_muscle_electrophysio1.01970271
95MP0000377_abnormal_hair_follicle1.01771271
96MP0004085_abnormal_heartbeat1.00060253
97MP0001984_abnormal_olfaction0.99658627
98MP0000762_abnormal_tongue_morphology0.99597539
99MP0002066_abnormal_motor_capabilities/c0.98357846
100MP0003119_abnormal_digestive_system0.97670126
101MP0005275_abnormal_skin_tensile0.97006420
102MP0002972_abnormal_cardiac_muscle0.96343301
103MP0008789_abnormal_olfactory_epithelium0.95799354
104MP0003011_delayed_dark_adaptation0.94868970
105MP0003938_abnormal_ear_development0.93954785
106MP0004142_abnormal_muscle_tone0.93775281
107MP0009046_muscle_twitch0.92421880
108MP0000747_muscle_weakness0.92299777
109MP0004924_abnormal_behavior0.91844965
110MP0005386_behavior/neurological_phenoty0.91844965
111MP0001849_ear_inflammation0.91820106
112MP0000647_abnormal_sebaceous_gland0.90571325
113MP0003942_abnormal_urinary_system0.89641624
114MP0001485_abnormal_pinna_reflex0.89550699
115MP0004084_abnormal_cardiac_muscle0.89277225
116MP0001348_abnormal_lacrimal_gland0.88507335
117MP0002697_abnormal_eye_size0.87476929
118MP0005620_abnormal_muscle_contractility0.86975264
119MP0004043_abnormal_pH_regulation0.86833123
120MP0009672_abnormal_birth_weight0.86476698
121MP0008569_lethality_at_weaning0.86430617
122MP0000013_abnormal_adipose_tissue0.86280483
123* MP0003755_abnormal_palate_morphology0.85746435
124MP0003890_abnormal_embryonic-extraembry0.85487860
125MP0002089_abnormal_postnatal_growth/wei0.84976517
126MP0005551_abnormal_eye_electrophysiolog0.84676536
127MP0001177_atelectasis0.84117314
128MP0002295_abnormal_pulmonary_circulatio0.83064346
129MP0009384_cardiac_valve_regurgitation0.82944925
130MP0003787_abnormal_imprinting0.82630977
131MP0002060_abnormal_skin_morphology0.82113740
132MP0004036_abnormal_muscle_relaxation0.81839998
133MP0009053_abnormal_anal_canal0.81667531
134MP0005195_abnormal_posterior_eye0.81291005
135MP0002102_abnormal_ear_morphology0.80741911
136MP0001188_hyperpigmentation0.80246858
137MP0000467_abnormal_esophagus_morphology0.79906525
138MP0002111_abnormal_tail_morphology0.79737509
139MP0001340_abnormal_eyelid_morphology0.79163637
140MP0001502_abnormal_circadian_rhythm0.78669750
141MP0002177_abnormal_outer_ear0.74518794
142MP0002095_abnormal_skin_pigmentation0.73596362
143MP0006138_congestive_heart_failure0.72990700
144MP0003567_abnormal_fetal_cardiomyocyte0.72091705
145MP0001286_abnormal_eye_development0.71384628
146MP0000534_abnormal_ureter_morphology0.70824904
147* MP0002092_abnormal_eye_morphology0.70346482
148* MP0002081_perinatal_lethality0.69554950
149* MP0002116_abnormal_craniofacial_bone0.67897714
150MP0009931_abnormal_skin_appearance0.67822155
151MP0004130_abnormal_muscle_cell0.67307171

Predicted human phenotypes

RankGene SetZ-score
1Erythroderma (HP:0001019)4.47045034
2Abnormality of nail color (HP:0100643)4.41384772
3Hypotrichosis (HP:0001006)4.28684306
4Increased IgE level (HP:0003212)4.03745349
5Neurofibrillary tangles (HP:0002185)3.77201268
6Palmoplantar hyperkeratosis (HP:0000972)3.70182442
7Palmar hyperkeratosis (HP:0010765)3.59173163
8Congenital ichthyosiform erythroderma (HP:0007431)3.44976419
9Supranuclear gaze palsy (HP:0000605)3.30075373
10Right ventricular cardiomyopathy (HP:0011663)3.29170669
11Woolly hair (HP:0002224)3.26610025
12Plantar hyperkeratosis (HP:0007556)3.21182666
13Myokymia (HP:0002411)3.19809056
14Abnormality of the dental root (HP:0006486)3.19655123
15Taurodontia (HP:0000679)3.19655123
16Abnormality of permanent molar morphology (HP:0011071)3.19655123
17Limb dystonia (HP:0002451)3.19096134
18Partial duplication of thumb phalanx (HP:0009944)3.15918229
19Cerebral inclusion bodies (HP:0100314)3.10018931
20Onycholysis (HP:0001806)3.08624324
21Split foot (HP:0001839)3.06701962
22Megalencephaly (HP:0001355)3.01390561
23Thick nail (HP:0001805)3.00400616
24Erythema (HP:0010783)2.98160921
25Abnormality of molar (HP:0011077)2.92663617
26Abnormality of molar morphology (HP:0011070)2.92663617
27Partial duplication of the phalanx of hand (HP:0009999)2.89249055
28Insidious onset (HP:0003587)2.83482481
29Termporal pattern (HP:0011008)2.83482481
30Ankle clonus (HP:0011448)2.81815218
31Turricephaly (HP:0000262)2.77272482
32Abnormality of the axillary hair (HP:0100134)2.76920265
33Abnormality of secondary sexual hair (HP:0009888)2.76920265
34Alopecia of scalp (HP:0002293)2.75770800
35Slow-growing hair (HP:0002217)2.74181048
36Abnormality of hair growth rate (HP:0011363)2.74181048
37Abnormality of the dental pulp (HP:0006479)2.71726128
38Abnormality of the corticospinal tract (HP:0002492)2.63628976
39Abnormality of the salivary glands (HP:0010286)2.61509238
40Pheochromocytoma (HP:0002666)2.58605954
41Degeneration of the lateral corticospinal tracts (HP:0002314)2.52903071
42Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.52903071
43Sparse scalp hair (HP:0002209)2.49942234
44Muscle fiber splitting (HP:0003555)2.42980169
45Palmoplantar keratoderma (HP:0000982)2.42896646
46Mixed hearing impairment (HP:0000410)2.40117029
47Bronchomalacia (HP:0002780)2.37120626
48Ulnar claw (HP:0001178)2.33934584
49Corneal erosion (HP:0200020)2.32771459
50Aplasia involving bones of the upper limbs (HP:0009823)2.31327709
51Aplasia of the phalanges of the hand (HP:0009802)2.31327709
52Aplasia involving bones of the extremities (HP:0009825)2.31327709
53Sudden death (HP:0001699)2.30923128
54Supernumerary nipples (HP:0002558)2.30906393
55Selective tooth agenesis (HP:0001592)2.28293100
56Nasolacrimal duct obstruction (HP:0000579)2.26332000
57Maternal diabetes (HP:0009800)2.25618740
58Cutaneous syndactyly (HP:0012725)2.24758134
59Hyporeflexia of lower limbs (HP:0002600)2.24559742
60Neuroendocrine neoplasm (HP:0100634)2.21056821
61Agitation (HP:0000713)2.20169778
62Broad alveolar ridges (HP:0000187)2.18141278
63Abnormality of the lacrimal duct (HP:0011481)2.16345003
64Peripheral hypomyelination (HP:0007182)2.15609303
65Visual hallucinations (HP:0002367)2.14293147
66Retinal dysplasia (HP:0007973)2.14217156
67Buphthalmos (HP:0000557)2.14216297
68Coronal craniosynostosis (HP:0004440)2.06129975
69Akinesia (HP:0002304)2.04303588
70Ventricular fibrillation (HP:0001663)2.03923138
71Hypoplasia of the brainstem (HP:0002365)2.03251895
72Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03251895
73Thickened helices (HP:0000391)2.02918581
74Dry hair (HP:0011359)2.01519972
75Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.99617224
76Conjunctival hamartoma (HP:0100780)1.98212009
77Difficulty running (HP:0009046)1.97411576
78Alacrima (HP:0000522)1.96634172
79Hypohidrosis (HP:0000966)1.94837154
80Hammertoe (HP:0001765)1.93652247
81Spastic gait (HP:0002064)1.93611335
82Rapidly progressive (HP:0003678)1.93318693
83Polyphagia (HP:0002591)1.93013233
84Hyperthyroidism (HP:0000836)1.90891031
85Foot dorsiflexor weakness (HP:0009027)1.90257096
86Sleep apnea (HP:0010535)1.89096595
87Prolonged QT interval (HP:0001657)1.87141944
88Amblyopia (HP:0000646)1.86548064
89Abnormality of the lower motor neuron (HP:0002366)1.86367437
90Action tremor (HP:0002345)1.86212785
91Neonatal short-limb short stature (HP:0008921)1.85074691
92Abnormality of the nasolacrimal system (HP:0000614)1.84470266
93Overriding aorta (HP:0002623)1.84312649
94Athetosis (HP:0002305)1.83521762
95Ventricular tachycardia (HP:0004756)1.83269750
96Hypoplasia of dental enamel (HP:0006297)1.82797197
97Absent hair (HP:0002298)1.82751008
98Morphological abnormality of the pyramidal tract (HP:0002062)1.82406121
99Hemiparesis (HP:0001269)1.82001215
100Abnormality of the foot musculature (HP:0001436)1.81897890
101Fetal akinesia sequence (HP:0001989)1.81842048
102Renal dysplasia (HP:0000110)1.81538974
103Cutaneous finger syndactyly (HP:0010554)1.78543127
104Congenital glaucoma (HP:0001087)1.78253671
105Concave nail (HP:0001598)1.77968649
106Focal seizures (HP:0007359)1.77840058
107Shallow orbits (HP:0000586)1.77249743
108Abnormal blistering of the skin (HP:0008066)1.76991993
109Pili torti (HP:0003777)1.76922197
110Acute necrotizing encephalopathy (HP:0006965)1.76324538
111Nail dystrophy (HP:0008404)1.75532239
112Atrioventricular block (HP:0001678)1.75124741
113Hypoplastic pelvis (HP:0008839)1.74283750
114Conical tooth (HP:0000698)1.73579506
115Lower limb muscle weakness (HP:0007340)1.72483836
116Narrow nasal bridge (HP:0000446)1.72450648
117Mutism (HP:0002300)1.72015253
118Postural tremor (HP:0002174)1.71686219
119Short middle phalanx of the 5th finger (HP:0004220)1.71662915
120Steppage gait (HP:0003376)1.71101266
121Oligodontia (HP:0000677)1.69621577
122Onion bulb formation (HP:0003383)1.68766413
123Neonatal death (HP:0003811)1.68546613
124Neoplasm of the peripheral nervous system (HP:0100007)1.67304656
125Overgrowth (HP:0001548)1.65097357
126Muscle hypertrophy of the lower extremities (HP:0008968)1.64437599
127Achilles tendon contracture (HP:0001771)1.63720914
128Bifid tongue (HP:0010297)1.63695688
129Absent eyebrow (HP:0002223)1.63680528
130Myotonia (HP:0002486)1.63547427
131Hypoplastic left heart (HP:0004383)1.63451798
132Lip pit (HP:0100267)1.63440920
133Anxiety (HP:0000739)1.61343827
134Pointed chin (HP:0000307)1.60494749
135Hyperacusis (HP:0010780)1.60216076
136Focal motor seizures (HP:0011153)1.58326996
137Abnormal eating behavior (HP:0100738)1.58115440
138Labial hypoplasia (HP:0000066)1.58036324
139Abnormality of glycolysis (HP:0004366)1.57699929
140Increased serum pyruvate (HP:0003542)1.57699929
141Increased variability in muscle fiber diameter (HP:0003557)1.56605926
142Morphological abnormality of the middle ear (HP:0008609)1.56478394
143Rib fusion (HP:0000902)1.56315941
144Progressive cerebellar ataxia (HP:0002073)1.56283089
145Arnold-Chiari malformation (HP:0002308)1.56149681
146Calf muscle hypertrophy (HP:0008981)1.55613928
147Germ cell neoplasia (HP:0100728)1.55569971
148Apathy (HP:0000741)1.54973799
149Progressive macrocephaly (HP:0004481)1.54867472
150Parakeratosis (HP:0001036)1.54284895
151Syncope (HP:0001279)1.54191481
152Abnormality of the calf musculature (HP:0001430)1.53529544
153Obstructive sleep apnea (HP:0002870)1.53419745
154Septo-optic dysplasia (HP:0100842)1.53412909
155Sparse eyelashes (HP:0000653)1.53269111
156Acanthosis nigricans (HP:0000956)1.52681182
157Type II lissencephaly (HP:0007260)1.52599939
158EMG: myopathic abnormalities (HP:0003458)1.52484316
159Pterygium (HP:0001059)1.52187891
160Abnormal hair laboratory examination (HP:0003328)1.52180479
161Humeroradial synostosis (HP:0003041)1.51638980
162Synostosis involving the elbow (HP:0003938)1.51638980
163Pachygyria (HP:0001302)1.51571080
164Exercise-induced myalgia (HP:0003738)1.51449652
165Exotropia (HP:0000577)1.51155118
166Leukodystrophy (HP:0002415)1.51151940
167Abnormality of the columella (HP:0009929)1.51050960
168Dysmetria (HP:0001310)1.50203395
169Lissencephaly (HP:0001339)1.50201448
170Asymmetric growth (HP:0100555)1.50039856
171Hepatoblastoma (HP:0002884)1.49798597
172Urinary urgency (HP:0000012)1.49651243
173Thoracic kyphosis (HP:0002942)1.49375076
174Torticollis (HP:0000473)1.48841543
175Choanal stenosis (HP:0000452)1.48206804
176Cerebral hypomyelination (HP:0006808)1.48181164
177Vertebral arch anomaly (HP:0008438)1.47809219
178Absent eyelashes (HP:0000561)1.47480034
179Hypoventilation (HP:0002791)1.47363293
180Depression (HP:0000716)1.47007328
181Fragile nails (HP:0001808)1.46703508

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK14.54871537
2PRPF4B3.73604600
3STK243.13807360
4MAP3K93.11554432
5EEF2K2.97462845
6RIPK12.62120299
7STK392.56823270
8PHKG22.45788517
9PHKG12.45788517
10LIMK12.38918982
11DYRK22.30698744
12LATS22.10849703
13NTRK22.04531968
14UHMK12.04309033
15TAOK21.98421397
16PAK61.94863497
17NTRK11.90681351
18BCR1.81364099
19PAK31.74751116
20TGFBR11.74624930
21PINK11.72998416
22WNK41.68066301
23MINK11.68017874
24KSR21.66834483
25EPHB21.66629848
26MAPK121.64687793
27MAPK131.51788105
28MAPKAPK31.49407919
29ARAF1.47044390
30WNK31.44411719
31FGFR21.43283283
32TESK21.40485571
33TYRO31.34034084
34PKN11.33298995
35FGFR11.30093069
36KSR11.29570321
37MAP3K21.29191370
38CSNK1G31.26952944
39NTRK31.24942124
40CSNK1G21.24679770
41RPS6KA21.24034372
42OXSR11.22607970
43EPHA21.21776456
44MAP3K41.20622481
45DDR21.20398259
46PNCK1.19529266
47CDK141.19046830
48EPHB11.18548236
49MAP3K61.17449819
50PRKD31.16515714
51CDK51.09195551
52FER1.08738854
53TRIB31.04711029
54ROCK21.02862039
55MAPK71.02380556
56SIK11.02243439
57LMTK21.02062471
58MET1.01058067
59BRAF0.98096218
60TIE10.96945765
61SGK20.96906827
62CSNK1A1L0.96793209
63MAP2K20.96463221
64MAPKAPK50.95821484
65CASK0.94047614
66ILK0.92594205
67CDK150.92130242
68CDK180.90477828
69RET0.89423908
70CSNK1G10.87325251
71GRK50.86827168
72MAP2K70.84347075
73MARK20.83251117
74CAMK2A0.82867068
75CDK11A0.81789539
76CAMK2D0.81099253
77CDK190.79968931
78SGK30.79718303
79PKN20.75969643
80PRKD10.75644477
81PDGFRA0.74128948
82SGK2230.73395924
83SGK4940.73395924
84TNIK0.73379232
85BMPR1B0.72958013
86ROCK10.72067695
87PLK20.71649181
88CAMK2B0.71576234
89MAPK150.70202782
90PRKCE0.70135315
91DYRK1A0.68642468
92ERBB30.68393721
93NME10.67947970
94MAP2K10.67541292
95EPHA40.66985990
96OBSCN0.66477181
97DMPK0.66446575
98FGR0.65734100
99SIK20.65686801
100STK110.64245695
101TLK10.64128711
102WNK10.64085209
103DYRK1B0.63160577
104PTK20.63140766
105RPS6KB10.61392447
106DYRK30.60598827
107INSRR0.59659902
108TESK10.58297435
109PRKCZ0.58012889
110MTOR0.57955767
111LRRK20.57218007
112MAP2K40.55739012
113DAPK20.53738451
114IRAK20.53684230
115MAP3K70.52339729
116MOS0.52220041
117CAMK10.51127292
118ICK0.51116228
119STK30.50882912
120DAPK30.50755246
121CAMK2G0.49717396
122MAP3K10.47655254
123PTK2B0.46976384
124ADRBK10.46523017
125PRKCG0.46265161
126CSNK1E0.45568424
127LATS10.45283948
128SGK10.44883547
129RPS6KC10.44735363
130RPS6KL10.44735363
131CAMK1G0.44051436
132MAPK90.43429912
133TAOK10.43129703
134ABL20.42454301
135CDC42BPA0.41926721
136AURKA0.41877108
137PTK60.41033038
138RPS6KA10.40125988
139PRKD20.39851340
140MAP3K110.36984158
141RPS6KA40.36448361
142RPS6KB20.34959433
143PRKCH0.32480934
144CDK30.32326631
145MAP3K100.31793178
146RPS6KA60.31418052

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.04820157
2Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.03446902
3Oxidative phosphorylation_Homo sapiens_hsa001902.28073566
4Axon guidance_Homo sapiens_hsa043602.08210718
5Parkinsons disease_Homo sapiens_hsa050122.04814232
6Steroid biosynthesis_Homo sapiens_hsa001002.02398387
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.97028294
8Cardiac muscle contraction_Homo sapiens_hsa042601.90380106
9Alzheimers disease_Homo sapiens_hsa050101.76516812
10Synaptic vesicle cycle_Homo sapiens_hsa047211.71193228
11GABAergic synapse_Homo sapiens_hsa047271.66611822
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62502213
13Serotonergic synapse_Homo sapiens_hsa047261.52695603
14Dopaminergic synapse_Homo sapiens_hsa047281.49675361
15Glutamatergic synapse_Homo sapiens_hsa047241.47500384
16Fatty acid elongation_Homo sapiens_hsa000621.46144459
17Ribosome_Homo sapiens_hsa030101.45981701
18Cocaine addiction_Homo sapiens_hsa050301.45856138
19Notch signaling pathway_Homo sapiens_hsa043301.45787362
20Butanoate metabolism_Homo sapiens_hsa006501.41756932
21Renal cell carcinoma_Homo sapiens_hsa052111.41709613
22Cholinergic synapse_Homo sapiens_hsa047251.41282778
23Insulin secretion_Homo sapiens_hsa049111.41033692
24Gap junction_Homo sapiens_hsa045401.40250781
25Circadian entrainment_Homo sapiens_hsa047131.39586291
26Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.37874845
27Vibrio cholerae infection_Homo sapiens_hsa051101.35773024
28Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.34851613
29Hedgehog signaling pathway_Homo sapiens_hsa043401.29928093
30Long-term depression_Homo sapiens_hsa047301.28192047
31Melanogenesis_Homo sapiens_hsa049161.27384249
32Tight junction_Homo sapiens_hsa045301.26630318
33Huntingtons disease_Homo sapiens_hsa050161.26145301
34Ether lipid metabolism_Homo sapiens_hsa005651.20598846
35Olfactory transduction_Homo sapiens_hsa047401.20324008
36Dilated cardiomyopathy_Homo sapiens_hsa054141.15263422
37Adherens junction_Homo sapiens_hsa045201.13804894
38Morphine addiction_Homo sapiens_hsa050321.12321716
39Dorso-ventral axis formation_Homo sapiens_hsa043201.11561091
40Sulfur metabolism_Homo sapiens_hsa009201.11260673
41Long-term potentiation_Homo sapiens_hsa047201.10109342
42Gastric acid secretion_Homo sapiens_hsa049711.09507934
43Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.09022727
44Hippo signaling pathway_Homo sapiens_hsa043901.07869572
45Basal cell carcinoma_Homo sapiens_hsa052171.07140953
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.07038747
47AMPK signaling pathway_Homo sapiens_hsa041521.06693764
48GnRH signaling pathway_Homo sapiens_hsa049121.06483921
49Nicotine addiction_Homo sapiens_hsa050331.05274209
50Histidine metabolism_Homo sapiens_hsa003401.04489582
51Estrogen signaling pathway_Homo sapiens_hsa049151.00414168
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.99298391
53Amphetamine addiction_Homo sapiens_hsa050310.98723273
54Phototransduction_Homo sapiens_hsa047440.98391084
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.97492259
56Renin secretion_Homo sapiens_hsa049240.95785893
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.95187643
58Maturity onset diabetes of the young_Homo sapiens_hsa049500.93462538
59Salivary secretion_Homo sapiens_hsa049700.93442161
60Glioma_Homo sapiens_hsa052140.91163768
61Circadian rhythm_Homo sapiens_hsa047100.90561816
62Taste transduction_Homo sapiens_hsa047420.90528035
63ErbB signaling pathway_Homo sapiens_hsa040120.90333976
64Protein export_Homo sapiens_hsa030600.89923495
65Oxytocin signaling pathway_Homo sapiens_hsa049210.89635152
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.88176489
67Ras signaling pathway_Homo sapiens_hsa040140.85358035
68Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.85160150
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84321906
70MAPK signaling pathway_Homo sapiens_hsa040100.83625157
71Amoebiasis_Homo sapiens_hsa051460.80366206
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80252471
73Collecting duct acid secretion_Homo sapiens_hsa049660.80112204
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80037607
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79746671
76Nitrogen metabolism_Homo sapiens_hsa009100.78021662
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.76853299
78Phospholipase D signaling pathway_Homo sapiens_hsa040720.75906813
79Vascular smooth muscle contraction_Homo sapiens_hsa042700.74326587
80Inositol phosphate metabolism_Homo sapiens_hsa005620.73970849
81Pancreatic secretion_Homo sapiens_hsa049720.73964558
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73015678
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72619347
84Prion diseases_Homo sapiens_hsa050200.71343358
85Sulfur relay system_Homo sapiens_hsa041220.69655330
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.69527568
87Alcoholism_Homo sapiens_hsa050340.69526004
88Glycerophospholipid metabolism_Homo sapiens_hsa005640.69283617
89Endometrial cancer_Homo sapiens_hsa052130.69045897
90ECM-receptor interaction_Homo sapiens_hsa045120.68290448
91* Wnt signaling pathway_Homo sapiens_hsa043100.67804404
92VEGF signaling pathway_Homo sapiens_hsa043700.67451892
93Rap1 signaling pathway_Homo sapiens_hsa040150.66306664
94Sphingolipid metabolism_Homo sapiens_hsa006000.66059385
95Colorectal cancer_Homo sapiens_hsa052100.65835207
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.65069721
97cAMP signaling pathway_Homo sapiens_hsa040240.64439064
98Bile secretion_Homo sapiens_hsa049760.61803013
99Endocytosis_Homo sapiens_hsa041440.61431697
100Bladder cancer_Homo sapiens_hsa052190.61370847
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60061766
102Focal adhesion_Homo sapiens_hsa045100.60056559
103cGMP-PKG signaling pathway_Homo sapiens_hsa040220.59803716
104Glucagon signaling pathway_Homo sapiens_hsa049220.59641919
105Melanoma_Homo sapiens_hsa052180.58789058
106Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.57656880
107Central carbon metabolism in cancer_Homo sapiens_hsa052300.56930039
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56561143
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.56379196
110Type II diabetes mellitus_Homo sapiens_hsa049300.56274300
111Pathways in cancer_Homo sapiens_hsa052000.55706210
112Linoleic acid metabolism_Homo sapiens_hsa005910.55674524
113alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54249943
114Proteoglycans in cancer_Homo sapiens_hsa052050.53722363
115Oocyte meiosis_Homo sapiens_hsa041140.51091992
116Fatty acid metabolism_Homo sapiens_hsa012120.50407833
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.50372166
118Choline metabolism in cancer_Homo sapiens_hsa052310.50155185
119Calcium signaling pathway_Homo sapiens_hsa040200.50069275
120Ovarian steroidogenesis_Homo sapiens_hsa049130.48569795
121Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48123440
122Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47934501
123Arginine and proline metabolism_Homo sapiens_hsa003300.44812490
124Protein digestion and absorption_Homo sapiens_hsa049740.44467644
125Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.44046843
126Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43942697
127Insulin signaling pathway_Homo sapiens_hsa049100.43569806
128SNARE interactions in vesicular transport_Homo sapiens_hsa041300.42811273

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