CTNNBL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the pre-mRNA-processing factor 19-cell division cycle 5-like (PRP19-CDC5L) protein complex, which activates pre-mRNA splicing and is an integral part of the spliceosome. The encoded protein is also a nuclear localization sequence binding protein, and binds to activation-induced deaminase and is important for antibody diversification. This gene may also be associated with the development of obesity. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)5.08904280
2DNA strand elongation (GO:0022616)4.85163380
3DNA replication initiation (GO:0006270)4.81125418
4maturation of SSU-rRNA (GO:0030490)4.66024023
5ribosomal small subunit assembly (GO:0000028)4.64119860
6telomere maintenance via semi-conservative replication (GO:0032201)4.63698094
7DNA unwinding involved in DNA replication (GO:0006268)4.50549358
8DNA replication checkpoint (GO:0000076)4.47558912
9ribosomal small subunit biogenesis (GO:0042274)4.24053984
10viral transcription (GO:0019083)4.20102462
11DNA deamination (GO:0045006)4.18141259
12telomere maintenance via recombination (GO:0000722)4.16504200
13nucleobase biosynthetic process (GO:0046112)4.12883860
14translational termination (GO:0006415)4.10048202
15protein localization to kinetochore (GO:0034501)4.03145867
16purine nucleobase biosynthetic process (GO:0009113)3.96885152
17mitotic recombination (GO:0006312)3.95154983
18formation of translation preinitiation complex (GO:0001731)3.92348210
19DNA replication-dependent nucleosome organization (GO:0034723)3.85004269
20DNA replication-dependent nucleosome assembly (GO:0006335)3.85004269
21mitotic metaphase plate congression (GO:0007080)3.82442786
22translational elongation (GO:0006414)3.80205585
23nucleotide-excision repair, DNA gap filling (GO:0006297)3.76707122
24establishment of viral latency (GO:0019043)3.73756928
25DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.72253737
26ribonucleoprotein complex biogenesis (GO:0022613)3.70275610
27pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.70174545
28regulation of cellular amino acid metabolic process (GO:0006521)3.67805421
29signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.65478575
30signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.65478575
31signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.65478575
32intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.64528869
33signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.64528869
34ribosomal large subunit biogenesis (GO:0042273)3.63442236
35spliceosomal snRNP assembly (GO:0000387)3.62908559
36translational initiation (GO:0006413)3.62753534
37protein localization to chromosome, centromeric region (GO:0071459)3.61784763
38telomere maintenance via telomere lengthening (GO:0010833)3.61425990
39mitotic nuclear envelope disassembly (GO:0007077)3.60474036
40ribosome biogenesis (GO:0042254)3.59746324
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.57645631
42folic acid-containing compound biosynthetic process (GO:0009396)3.53496230
43CENP-A containing nucleosome assembly (GO:0034080)3.53074093
44chromatin remodeling at centromere (GO:0031055)3.52778417
45signal transduction involved in DNA integrity checkpoint (GO:0072401)3.52417605
46signal transduction involved in DNA damage checkpoint (GO:0072422)3.52417605
47nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.49275344
48cotranslational protein targeting to membrane (GO:0006613)3.48877974
49IMP biosynthetic process (GO:0006188)3.48717775
50signal transduction involved in cell cycle checkpoint (GO:0072395)3.48301324
51protein targeting to ER (GO:0045047)3.46461208
52establishment of protein localization to mitochondrial membrane (GO:0090151)3.45435520
53pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.41822752
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.41739717
55rRNA processing (GO:0006364)3.41026255
56regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.37203201
57protein neddylation (GO:0045116)3.37122591
58cellular protein complex disassembly (GO:0043624)3.35512275
59positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.34367120
60mitotic sister chromatid segregation (GO:0000070)3.34263133
61DNA replication-independent nucleosome assembly (GO:0006336)3.33398405
62DNA replication-independent nucleosome organization (GO:0034724)3.33398405
63metaphase plate congression (GO:0051310)3.32785792
64nuclear envelope disassembly (GO:0051081)3.31327614
65membrane disassembly (GO:0030397)3.31327614
66negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.30206712
67regulation of mitochondrial translation (GO:0070129)3.29763528
68rRNA metabolic process (GO:0016072)3.29522188
69antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:3.29309977
70anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.29147107
71viral life cycle (GO:0019058)3.27294019
72mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.26191425
73establishment of protein localization to endoplasmic reticulum (GO:0072599)3.26012295
74protein localization to endoplasmic reticulum (GO:0070972)3.25206108
75DNA ligation (GO:0006266)3.24330714
76somatic diversification of immune receptors via somatic mutation (GO:0002566)3.22634636
77somatic hypermutation of immunoglobulin genes (GO:0016446)3.22634636
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.22026047
79kinetochore organization (GO:0051383)3.19723842
80positive regulation of ligase activity (GO:0051351)3.18398559
81transcription-coupled nucleotide-excision repair (GO:0006283)3.17980585
82spliceosomal complex assembly (GO:0000245)3.17907847
83regulation of translation in response to stress (GO:0043555)3.17378339
84histone exchange (GO:0043486)3.16774063
85antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.16485033
86establishment of chromosome localization (GO:0051303)3.16129816
87protein deneddylation (GO:0000338)3.13618459
88protein complex disassembly (GO:0043241)3.13598716
89attachment of spindle microtubules to kinetochore (GO:0008608)3.13234322
90rRNA modification (GO:0000154)3.12995597
91cullin deneddylation (GO:0010388)3.12607429
92mismatch repair (GO:0006298)3.11567300
93positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.11348001
94establishment of integrated proviral latency (GO:0075713)3.11079184
95mitotic chromosome condensation (GO:0007076)3.09965896
96histone H2A acetylation (GO:0043968)3.09826903
97IMP metabolic process (GO:0046040)3.09785039
98negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.08852717
99negative regulation of ligase activity (GO:0051352)3.08852717
100kinetochore assembly (GO:0051382)3.06412274
101proteasome assembly (GO:0043248)3.04525531
102protein K6-linked ubiquitination (GO:0085020)3.03780535
103postreplication repair (GO:0006301)3.02593027
104negative regulation of chromosome segregation (GO:0051985)3.01994684
105sister chromatid segregation (GO:0000819)3.01888676
106macromolecular complex disassembly (GO:0032984)3.01852457
107negative regulation of mitotic sister chromatid segregation (GO:0033048)3.00474480
108negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.00474480
109negative regulation of sister chromatid segregation (GO:0033046)3.00474480
110negative regulation of mitotic sister chromatid separation (GO:2000816)3.00474480
111viral mRNA export from host cell nucleus (GO:0046784)2.99036937
112pseudouridine synthesis (GO:0001522)2.98454887
113regulation of chromosome segregation (GO:0051983)2.97564759
114RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96632548
115mRNA splicing, via spliceosome (GO:0000398)2.96632548
116RNA splicing, via transesterification reactions (GO:0000375)2.96079217
117regulation of ubiquitin-protein transferase activity (GO:0051438)2.95963836
118translation (GO:0006412)2.95513061
119cell cycle G1/S phase transition (GO:0044843)2.95216391
120G1/S transition of mitotic cell cycle (GO:0000082)2.95216391
121deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.94910856
122nuclear pore organization (GO:0006999)2.94827700
123negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.94786788
124ribosome assembly (GO:0042255)2.93518523
125DNA duplex unwinding (GO:0032508)2.93125172
126DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.91899213
127heme metabolic process (GO:0042168)2.90229463
128purine nucleotide salvage (GO:0032261)2.86091454
129pyrimidine nucleotide catabolic process (GO:0006244)2.85256531
130regulation of ligase activity (GO:0051340)2.84177643
131chaperone-mediated protein transport (GO:0072321)2.81624900
132protein complex biogenesis (GO:0070271)2.81338804
133purine-containing compound salvage (GO:0043101)2.79723422
134negative regulation of protein ubiquitination (GO:0031397)2.78853733
135deoxyribonucleotide catabolic process (GO:0009264)2.78446761
136deoxyribose phosphate catabolic process (GO:0046386)2.75437372
137protein targeting to mitochondrion (GO:0006626)2.75338751
138mitochondrial respiratory chain complex assembly (GO:0033108)2.72915440
139oxidative phosphorylation (GO:0006119)2.72531353
140heme biosynthetic process (GO:0006783)2.71502224
141positive regulation of cell cycle arrest (GO:0071158)2.71239950
142DNA catabolic process, exonucleolytic (GO:0000738)2.71060407
143energy coupled proton transport, down electrochemical gradient (GO:0015985)2.68413019
144ATP synthesis coupled proton transport (GO:0015986)2.68413019
145regulation of cellular amine metabolic process (GO:0033238)2.67592284
146tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66720688
147RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66720688
148negative regulation of protein modification by small protein conjugation or removal (GO:1903321)2.66165608
149signal transduction in response to DNA damage (GO:0042770)2.64725144
150pentose metabolic process (GO:0019321)2.62402078
151response to interferon-beta (GO:0035456)2.61993474
152DNA damage response, detection of DNA damage (GO:0042769)2.61977956
153cellular response to interferon-beta (GO:0035458)2.59359481
154mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.58256771
155mitochondrial respiratory chain complex I assembly (GO:0032981)2.58256771
156NADH dehydrogenase complex assembly (GO:0010257)2.58256771
157deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.56479770
158protein localization to mitochondrion (GO:0070585)2.51777950
159positive regulation of megakaryocyte differentiation (GO:0045654)2.49455709
160antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.49345239
161establishment of protein localization to mitochondrion (GO:0072655)2.47867586
162DNA topological change (GO:0006265)2.47697625
163transcription elongation from RNA polymerase III promoter (GO:0006385)2.45191371
164termination of RNA polymerase III transcription (GO:0006386)2.45191371
165respiratory chain complex IV assembly (GO:0008535)2.45028559
166cytochrome complex assembly (GO:0017004)2.44854071
167replication fork processing (GO:0031297)2.44610718

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.72076993
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.13244401
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.65428114
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.57663056
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43193438
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.26335062
7EST1_17652178_ChIP-ChIP_JURKAT_Human3.10515488
8GABP_17652178_ChIP-ChIP_JURKAT_Human3.01338622
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.00751987
10JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.97964992
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.94674692
12MYC_19079543_ChIP-ChIP_MESCs_Mouse2.94408620
13* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.87430063
14* ETS1_20019798_ChIP-Seq_JURKAT_Human2.86757400
15MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78540203
16HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.76937712
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.76628474
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.49044822
19XRN2_22483619_ChIP-Seq_HELA_Human2.47052213
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.31006144
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30243390
22VDR_23849224_ChIP-Seq_CD4+_Human2.29437636
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.10720391
24FOXP3_21729870_ChIP-Seq_TREG_Human2.07022198
25CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.04185373
26E2F1_18555785_ChIP-Seq_MESCs_Mouse2.02245963
27ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01007971
28HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95591043
29* GABP_19822575_ChIP-Seq_HepG2_Human1.93844840
30TTF2_22483619_ChIP-Seq_HELA_Human1.91873906
31MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.91236164
32THAP11_20581084_ChIP-Seq_MESCs_Mouse1.90663441
33DCP1A_22483619_ChIP-Seq_HELA_Human1.89771198
34CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.86660065
35AR_21909140_ChIP-Seq_LNCAP_Human1.86186374
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.84788879
37CIITA_25753668_ChIP-Seq_RAJI_Human1.84405268
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.84322185
39IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.83217536
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78393445
41MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77773092
42YY1_21170310_ChIP-Seq_MESCs_Mouse1.76307204
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.69942893
44BP1_19119308_ChIP-ChIP_Hs578T_Human1.67008471
45NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65983444
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.63906107
47PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.60304018
48YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.59483112
49HOXB4_20404135_ChIP-ChIP_EML_Mouse1.58576379
50CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.56534282
51MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56120520
52FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55268421
53IRF8_22096565_ChIP-ChIP_GC-B_Human1.54927261
54IRF8_21731497_ChIP-ChIP_J774_Mouse1.54819215
55MYC_22102868_ChIP-Seq_BL_Human1.53311026
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.52901395
57SRF_21415370_ChIP-Seq_HL-1_Mouse1.52176753
58ELK1_19687146_ChIP-ChIP_HELA_Human1.48379131
59ZFX_18555785_ChIP-Seq_MESCs_Mouse1.45887269
60KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.41283596
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.41224969
62PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37230951
63KDM5A_27292631_Chip-Seq_BREAST_Human1.33695610
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.33019201
65ERG_20887958_ChIP-Seq_HPC-7_Mouse1.27242398
66SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.26892281
67POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.25504351
68EGR1_19374776_ChIP-ChIP_THP-1_Human1.23276011
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.22609888
70TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.20432686
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.18473792
72NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.17841286
73SOX2_18555785_ChIP-Seq_MESCs_Mouse1.17220216
74ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17164207
75STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16444451
76SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.14083076
77VDR_21846776_ChIP-Seq_THP-1_Human1.13580359
78STAT4_19710469_ChIP-ChIP_TH1__Mouse1.13551290
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11466706
80KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.11162386
81TFEB_21752829_ChIP-Seq_HELA_Human1.10692347
82POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10432403
83E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.09737122
84PADI4_21655091_ChIP-ChIP_MCF-7_Human1.08813941
85* E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.08300950
86HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08086614
87CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.07438638
88STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06037859
89DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05811352
90MYC_18940864_ChIP-ChIP_HL60_Human1.04690239
91CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.04430816
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.03425796
93TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00512084
94HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.99271694
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.99081912
96KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.98854482
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97309153
98* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97007903
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93630226
100CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.93493180
101BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93074445
102* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.92857742
103NANOG_21062744_ChIP-ChIP_HESCs_Human0.89250315
104* SPI1_23547873_ChIP-Seq_NB4_Human0.87992029
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.87430135
106RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86924844
107GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85843655
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85177362
109ELK1_22589737_ChIP-Seq_MCF10A_Human0.83449737
110MYB_26560356_Chip-Seq_TH2_Human0.81852674
111GATA1_22025678_ChIP-Seq_K562_Human0.79103180
112FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.76652946
113IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.76593719
114OCT4_18692474_ChIP-Seq_MEFs_Mouse0.76260402
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75503123
116* YY1_22570637_ChIP-Seq_MALME-3M_Human0.73755340
117CTCF_18555785_ChIP-Seq_MESCs_Mouse0.71874676
118ELF1_20517297_ChIP-Seq_JURKAT_Human0.71702918
119MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.70792788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.51670927
2MP0010094_abnormal_chromosome_stability5.07861820
3MP0003111_abnormal_nucleus_morphology4.52793642
4MP0004957_abnormal_blastocyst_morpholog4.43681577
5MP0003077_abnormal_cell_cycle4.09916500
6MP0008058_abnormal_DNA_repair3.73140525
7MP0008057_abnormal_DNA_replication3.71600031
8MP0008007_abnormal_cellular_replicative3.15720779
9MP0008877_abnormal_DNA_methylation2.81462836
10MP0008932_abnormal_embryonic_tissue2.79114438
11MP0002148_abnormal_hypersensitivity_rea2.40881725
12MP0003656_abnormal_erythrocyte_physiolo2.36525110
13MP0002396_abnormal_hematopoietic_system2.29607485
14MP0001730_embryonic_growth_arrest2.27088757
15MP0000350_abnormal_cell_proliferation2.17957351
16MP0006036_abnormal_mitochondrial_physio2.05178888
17MP0001853_heart_inflammation2.04956950
18MP0009785_altered_susceptibility_to2.04217533
19MP0005464_abnormal_platelet_physiology2.00821900
20MP0004147_increased_porphyrin_level1.99894904
21MP0003303_peritoneal_inflammation1.98221231
22MP0003763_abnormal_thymus_physiology1.94931467
23MP0003123_paternal_imprinting1.87585476
24MP0009333_abnormal_splenocyte_physiolog1.84289873
25MP0006082_CNS_inflammation1.82992683
26MP0003786_premature_aging1.82602857
27MP0002139_abnormal_hepatobiliary_system1.75435716
28MP0002210_abnormal_sex_determination1.74199783
29MP0006035_abnormal_mitochondrial_morpho1.70868937
30MP0010307_abnormal_tumor_latency1.69966517
31MP0000490_abnormal_crypts_of1.69185956
32MP0003718_maternal_effect1.69129283
33MP0005058_abnormal_lysosome_morphology1.67183950
34MP0006292_abnormal_olfactory_placode1.66323850
35MP0005451_abnormal_body_composition1.64871612
36MP0001697_abnormal_embryo_size1.62530134
37MP0001929_abnormal_gametogenesis1.62477226
38MP0010030_abnormal_orbit_morphology1.61258666
39MP0003436_decreased_susceptibility_to1.58325077
40MP0002080_prenatal_lethality1.57949386
41MP0005380_embryogenesis_phenotype1.57829823
42MP0001672_abnormal_embryogenesis/_devel1.57829823
43MP0005000_abnormal_immune_tolerance1.55421951
44MP0009764_decreased_sensitivity_to1.54399551
45MP0000313_abnormal_cell_death1.54305852
46MP0002019_abnormal_tumor_incidence1.54089219
47MP0005025_abnormal_response_to1.49657933
48MP0002085_abnormal_embryonic_tissue1.49028694
49MP0009278_abnormal_bone_marrow1.44077526
50MP0006054_spinal_hemorrhage1.42962990
51MP0001145_abnormal_male_reproductive1.41738273
52MP0005084_abnormal_gallbladder_morpholo1.39956746
53MP0010352_gastrointestinal_tract_polyps1.39547180
54MP0009697_abnormal_copulation1.38648616
55MP0000703_abnormal_thymus_morphology1.38528774
56MP0003806_abnormal_nucleotide_metabolis1.38400320
57MP0003984_embryonic_growth_retardation1.38341529
58MP0000372_irregular_coat_pigmentation1.37342836
59MP0002419_abnormal_innate_immunity1.37017167
60MP0000465_gastrointestinal_hemorrhage1.34962217
61MP0002088_abnormal_embryonic_growth/wei1.34821342
62MP0004808_abnormal_hematopoietic_stem1.34029359
63MP0001764_abnormal_homeostasis1.33040433
64MP0002084_abnormal_developmental_patter1.31559349
65MP0002398_abnormal_bone_marrow1.27925197
66MP0000653_abnormal_sex_gland1.27253252
67MP0002653_abnormal_ependyma_morphology1.27059257
68MP0009379_abnormal_foot_pigmentation1.24672857
69MP0000358_abnormal_cell_content/1.17369969
70MP0008469_abnormal_protein_level1.16809904
71MP0003121_genomic_imprinting1.15630019
72MP0005410_abnormal_fertilization1.15457343
73MP0002722_abnormal_immune_system1.14312720
74MP0003315_abnormal_perineum_morphology1.14265399
75MP0003075_altered_response_to1.13910652
76MP0000689_abnormal_spleen_morphology1.10664799
77MP0003698_abnormal_male_reproductive1.09481163
78MP0004197_abnormal_fetal_growth/weight/1.07481554
79MP0002132_abnormal_respiratory_system1.06182909
80MP0009763_increased_sensitivity_to1.06135322
81MP0000343_altered_response_to1.04904352
82MP0002086_abnormal_extraembryonic_tissu1.04248242
83MP0001845_abnormal_inflammatory_respons1.04220665
84MP0003890_abnormal_embryonic-extraembry1.04071663
85MP0005387_immune_system_phenotype1.03701294
86MP0001790_abnormal_immune_system1.03701294
87MP0002429_abnormal_blood_cell1.03357367
88MP0000516_abnormal_urinary_system1.03206758
89MP0005367_renal/urinary_system_phenotyp1.03206758
90MP0009765_abnormal_xenobiotic_induced1.02363068
91MP0009840_abnormal_foam_cell0.99385429
92MP0003724_increased_susceptibility_to0.99173730
93MP0001119_abnormal_female_reproductive0.98257200
94MP0001293_anophthalmia0.97935024
95MP0002160_abnormal_reproductive_system0.96606310
96MP0008875_abnormal_xenobiotic_pharmacok0.95351357
97MP0008995_early_reproductive_senescence0.94158040
98MP0005671_abnormal_response_to0.93153820
99MP0008789_abnormal_olfactory_epithelium0.90610036
100MP0000049_abnormal_middle_ear0.90379557
101MP0000716_abnormal_immune_system0.89837346
102MP0004133_heterotaxia0.89413517
103MP0005174_abnormal_tail_pigmentation0.89326355
104MP0008260_abnormal_autophagy0.89033757
105MP0003195_calcinosis0.88477276
106MP0000858_altered_metastatic_potential0.88347591
107MP0005397_hematopoietic_system_phenotyp0.88297622
108MP0001545_abnormal_hematopoietic_system0.88297622
109MP0001835_abnormal_antigen_presentation0.87773998
110MP0005165_increased_susceptibility_to0.85945158
111MP0003119_abnormal_digestive_system0.85373374
112MP0010155_abnormal_intestine_physiology0.84860540
113MP0005389_reproductive_system_phenotype0.84536666
114MP0003011_delayed_dark_adaptation0.83158390
115MP0002161_abnormal_fertility/fecundity0.82839553
116MP0005636_abnormal_mineral_homeostasis0.82422009
117MP0003448_altered_tumor_morphology0.80450153
118MP0002751_abnormal_autonomic_nervous0.77602843
119MP0005384_cellular_phenotype0.76447466
120MP0002420_abnormal_adaptive_immunity0.75679408
121MP0000685_abnormal_immune_system0.75629822
122MP0008873_increased_physiological_sensi0.75590430
123MP0003191_abnormal_cellular_cholesterol0.75077729
124MP0005395_other_phenotype0.74743755
125MP0001819_abnormal_immune_cell0.74390766
126MP0002405_respiratory_system_inflammati0.73966414
127MP0001727_abnormal_embryo_implantation0.73578487
128MP0002095_abnormal_skin_pigmentation0.72296394
129MP0001800_abnormal_humoral_immune0.72197246
130MP0005075_abnormal_melanosome_morpholog0.69233719
131MP0009672_abnormal_birth_weight0.69209829
132MP0000015_abnormal_ear_pigmentation0.68165009
133MP0003221_abnormal_cardiomyocyte_apopto0.66272954
134MP0002102_abnormal_ear_morphology0.65946854
135MP0002452_abnormal_antigen_presenting0.65825854
136MP0000428_abnormal_craniofacial_morphol0.65016113
137MP0005076_abnormal_cell_differentiation0.65001150
138MP0003943_abnormal_hepatobiliary_system0.64696847
139MP0003186_abnormal_redox_activity0.64423857
140MP0002111_abnormal_tail_morphology0.64221387
141MP0000537_abnormal_urethra_morphology0.63529732
142MP0003567_abnormal_fetal_cardiomyocyte0.63286148
143MP0000678_abnormal_parathyroid_gland0.63243566
144MP0005621_abnormal_cell_physiology0.60544988
145MP0003937_abnormal_limbs/digits/tail_de0.60525468
146MP0001919_abnormal_reproductive_system0.60170171
147MP0002092_abnormal_eye_morphology0.59452676
148MP0005499_abnormal_olfactory_system0.59222009
149MP0005394_taste/olfaction_phenotype0.59222009
150MP0002723_abnormal_immune_serum0.58515757
151MP0001915_intracranial_hemorrhage0.58498419

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.41829347
2Reticulocytopenia (HP:0001896)5.03565468
3Abnormality of cells of the erythroid lineage (HP:0012130)4.08305210
4Breast hypoplasia (HP:0003187)4.01561289
5Abnormal number of erythroid precursors (HP:0012131)3.94335588
6Acute encephalopathy (HP:0006846)3.80576413
7Abnormality of the anterior horn cell (HP:0006802)3.70442137
8Degeneration of anterior horn cells (HP:0002398)3.70442137
9Acute necrotizing encephalopathy (HP:0006965)3.70360242
10Mitochondrial inheritance (HP:0001427)3.69011531
11Abnormal mitochondria in muscle tissue (HP:0008316)3.65413209
12Patellar aplasia (HP:0006443)3.49778804
13Hepatocellular necrosis (HP:0001404)3.48478276
14Increased CSF lactate (HP:0002490)3.45089079
15Colon cancer (HP:0003003)3.43338986
16Agnosia (HP:0010524)3.41641415
17Petechiae (HP:0000967)3.39897686
18Chromsome breakage (HP:0040012)3.36824543
19Microvesicular hepatic steatosis (HP:0001414)3.31707505
20Hepatic necrosis (HP:0002605)3.31270306
21Selective tooth agenesis (HP:0001592)3.30814893
22Ependymoma (HP:0002888)3.30444573
23Chromosomal breakage induced by crosslinking agents (HP:0003221)3.28107892
24Aplasia/Hypoplasia of the patella (HP:0006498)3.26686131
25Carpal bone hypoplasia (HP:0001498)3.24746981
26Medulloblastoma (HP:0002885)3.17272187
27Hypoplasia of the capital femoral epiphysis (HP:0003090)3.13184847
28Progressive macrocephaly (HP:0004481)3.13072935
29Impulsivity (HP:0100710)3.11545772
30Macrocytic anemia (HP:0001972)3.05230544
31Pallor (HP:0000980)3.00829278
32Cerebral edema (HP:0002181)2.98586782
33Oral leukoplakia (HP:0002745)2.95220673
34Cerebral hypomyelination (HP:0006808)2.93658509
35Increased serum pyruvate (HP:0003542)2.92148289
3611 pairs of ribs (HP:0000878)2.90277206
37Increased intramyocellular lipid droplets (HP:0012240)2.88359832
38Rhabdomyosarcoma (HP:0002859)2.81695117
39Nausea (HP:0002018)2.81260042
40Meckel diverticulum (HP:0002245)2.80451873
41Abnormal protein glycosylation (HP:0012346)2.78256465
42Abnormal glycosylation (HP:0012345)2.78256465
43Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.78256465
44Abnormal protein N-linked glycosylation (HP:0012347)2.78256465
45Increased hepatocellular lipid droplets (HP:0006565)2.76142454
46Vacuolated lymphocytes (HP:0001922)2.76027810
47Abnormality of the ileum (HP:0001549)2.74317307
48Panhypogammaglobulinemia (HP:0003139)2.73890054
49Abnormality of the preputium (HP:0100587)2.73382513
50Absent thumb (HP:0009777)2.71392175
51Abnormality of glycolysis (HP:0004366)2.71297129
52Abnormality of chromosome stability (HP:0003220)2.71013385
53Renal Fanconi syndrome (HP:0001994)2.70898044
54Lactic acidosis (HP:0003128)2.67896134
55Increased serum ferritin (HP:0003281)2.63066578
56Abnormal gallbladder physiology (HP:0012438)2.60123954
57Cholecystitis (HP:0001082)2.60123954
58Thrombocytosis (HP:0001894)2.58769513
59Lipid accumulation in hepatocytes (HP:0006561)2.56269310
60Aplastic anemia (HP:0001915)2.55117610
61Rough bone trabeculation (HP:0100670)2.54838864
62Generalized aminoaciduria (HP:0002909)2.52845226
63Stomatitis (HP:0010280)2.50532624
64Aplasia/Hypoplasia of the sacrum (HP:0008517)2.49389237
65Abnormality of glycolipid metabolism (HP:0010969)2.48705878
66Abnormality of liposaccharide metabolism (HP:0010968)2.48705878
67Abnormality of glycosphingolipid metabolism (HP:0004343)2.48705878
683-Methylglutaconic aciduria (HP:0003535)2.46212406
69Aplasia/Hypoplasia of the uvula (HP:0010293)2.45203685
70Premature graying of hair (HP:0002216)2.43687293
71Atrophy/Degeneration involving motor neurons (HP:0007373)2.43471845
72Hepatosplenomegaly (HP:0001433)2.42695694
73Increased muscle lipid content (HP:0009058)2.41741544
74Abnormality of iron homeostasis (HP:0011031)2.40578185
75Exercise intolerance (HP:0003546)2.40193640
76Reduced antithrombin III activity (HP:0001976)2.39965490
77Premature ovarian failure (HP:0008209)2.38988875
78Abnormal number of incisors (HP:0011064)2.36064346
79Neoplasm of the pancreas (HP:0002894)2.35787920
80Respiratory failure (HP:0002878)2.35687958
81Bone marrow hypocellularity (HP:0005528)2.32338943
82Increased IgM level (HP:0003496)2.31585111
83Secondary amenorrhea (HP:0000869)2.28767642
84Horseshoe kidney (HP:0000085)2.28677849
85Emotional lability (HP:0000712)2.28641734
86Small intestinal stenosis (HP:0012848)2.28572708
87Duodenal stenosis (HP:0100867)2.28572708
88Absent epiphyses (HP:0010577)2.27327231
89Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.27327231
90Exertional dyspnea (HP:0002875)2.23488903
91Basal cell carcinoma (HP:0002671)2.22930963
92Limb hypertonia (HP:0002509)2.21401101
93Lethargy (HP:0001254)2.21148580
94Myelodysplasia (HP:0002863)2.20127364
95Abnormality of B cell number (HP:0010975)2.18897546
96Absent radius (HP:0003974)2.18848414
97Trismus (HP:0000211)2.18607977
98Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.18572917
99Sloping forehead (HP:0000340)2.16111141
100Neoplasm of striated muscle (HP:0009728)2.15983440
101B lymphocytopenia (HP:0010976)2.15569050
102Abnormal lung lobation (HP:0002101)2.15252614
103Microretrognathia (HP:0000308)2.13883089
104Abnormality of transition element cation homeostasis (HP:0011030)2.12876221
105Recurrent viral infections (HP:0004429)2.09365782
106Purpura (HP:0000979)2.08692138
107Abnormality of the astrocytes (HP:0100707)2.08286467
108Astrocytoma (HP:0009592)2.08286467
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.07371720
110Cellular immunodeficiency (HP:0005374)2.07305450
111Amaurosis fugax (HP:0100576)2.07023240
112Tracheoesophageal fistula (HP:0002575)2.06582687
113Optic nerve coloboma (HP:0000588)2.06078970
114Type I transferrin isoform profile (HP:0003642)2.05262395
115Lymphoma (HP:0002665)2.03534720
116Respiratory difficulties (HP:0002880)2.02899994
117Absent forearm bone (HP:0003953)2.00900550
118Aplasia involving forearm bones (HP:0009822)2.00900550
119Poikiloderma (HP:0001029)2.00443200
120Triphalangeal thumb (HP:0001199)1.99813189
121CNS demyelination (HP:0007305)1.99588382
122Abnormality of dicarboxylic acid metabolism (HP:0010995)1.96473449
123Dicarboxylic aciduria (HP:0003215)1.96473449
124Abnormality of the labia minora (HP:0012880)1.96338295
125Slender long bone (HP:0003100)1.95997630
126Ragged-red muscle fibers (HP:0003200)1.93405895
127Abdominal situs inversus (HP:0003363)1.91935832
128Abnormality of abdominal situs (HP:0011620)1.91935832
129Pancytopenia (HP:0001876)1.91928202
130Ectopic kidney (HP:0000086)1.91654171
131Atresia of the external auditory canal (HP:0000413)1.91633536
132Glioma (HP:0009733)1.91503890
133Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.91438038
134IgM deficiency (HP:0002850)1.90806303
135Increased nuchal translucency (HP:0010880)1.89884483
136Loss of speech (HP:0002371)1.89802673
137Abnormality of DNA repair (HP:0003254)1.89257218
138Abnormality of the carotid arteries (HP:0005344)1.89237442
139Abnormality of the heme biosynthetic pathway (HP:0010472)1.89221460
140Cleft eyelid (HP:0000625)1.88362440
141Elevated erythrocyte sedimentation rate (HP:0003565)1.86200328
142Opisthotonus (HP:0002179)1.86144156
143Pulmonary fibrosis (HP:0002206)1.84911331
144Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.84361493
145Decreased activity of mitochondrial respiratory chain (HP:0008972)1.84361493
146Hypoplasia of the radius (HP:0002984)1.83681751
147Abnormality of the prostate (HP:0008775)1.83430997
148Personality changes (HP:0000751)1.82477594
149Posterior subcapsular cataract (HP:0007787)1.82015026
150Abnormality of reticulocytes (HP:0004312)1.81754803
151CNS hypomyelination (HP:0003429)1.81283928
152Neutropenia (HP:0001875)1.81148869
153Prolonged bleeding time (HP:0003010)1.80983523
154Abnormality of macrophages (HP:0004311)1.80282950
155Supernumerary spleens (HP:0009799)1.79159971
156Abnormality of the duodenum (HP:0002246)1.79125369
157Autoimmune hemolytic anemia (HP:0001890)1.78784608
158Hyperglycinemia (HP:0002154)1.78340733
159Multiple enchondromatosis (HP:0005701)1.76472806
160Neoplasm of the colon (HP:0100273)1.76458212
161Progressive microcephaly (HP:0000253)1.76201635
162Combined immunodeficiency (HP:0005387)1.75784503
163Duplicated collecting system (HP:0000081)1.73859314
164Proximal placement of thumb (HP:0009623)1.73576039
165Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.73307124
166Pendular nystagmus (HP:0012043)1.71344716
167Increased serum lactate (HP:0002151)1.71220965
168Glossoptosis (HP:0000162)1.70836770
169Muscle fiber atrophy (HP:0100295)1.70471386
170Abnormal trabecular bone morphology (HP:0100671)1.70260491

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.94346216
2BUB14.93268926
3CDC74.08646747
4WEE13.86741781
5TLK13.08200431
6SRPK12.85160986
7EIF2AK12.73489570
8TESK22.67570524
9BCKDK2.58943336
10NEK22.47984380
11TSSK62.46764011
12MAP4K22.32686184
13PASK2.28227148
14TTK2.17642793
15VRK12.14912798
16STK162.05378529
17PLK12.00643155
18DYRK32.00609387
19EIF2AK31.96072623
20NUAK11.91092747
21ACVR1B1.87970996
22ATR1.78931281
23FLT31.77303774
24NME21.68999496
25PLK41.68795992
26BRSK21.62581977
27MAP3K101.62394839
28CDK71.61511510
29RPS6KB21.59188131
30AURKB1.56292753
31TRIM281.53937645
32IRAK31.48600827
33AURKA1.48319906
34NEK11.47685282
35CHEK21.47475134
36EEF2K1.46449810
37CCNB11.43612420
38TAF11.43603897
39PLK31.42985386
40TGFBR11.41328770
41MKNK11.39610702
42MATK1.39219549
43BRSK11.29248313
44MAP3K121.24439801
45MAP4K11.21448449
46CDK81.20239070
47TESK11.19359257
48STK101.19034281
49TAOK21.17276221
50MAP3K81.17257815
51ABL21.17027146
52RPS6KA41.15877017
53SCYL21.15597594
54CHEK11.14254476
55GRK71.10408520
56PDK31.09276250
57PDK41.09276250
58CDK41.02320895
59MAP3K111.01869399
60IKBKB1.00913448
61CLK10.97145167
62KIT0.95345435
63DYRK20.95260167
64PIM20.92519129
65BRAF0.90074808
66MKNK20.87641103
67TBK10.85080850
68PAK40.83401230
69PIM10.83173804
70KDR0.82520029
71ATM0.80569437
72MAPKAPK30.80111032
73CDK20.79284803
74LRRK20.78984441
75TIE10.78811386
76FGR0.76865670
77CSF1R0.73861614
78CDK120.72917953
79CSNK2A20.72456070
80CSNK2A10.69019709
81STK40.67433901
82INSRR0.67339734
83BTK0.63498706
84CDK10.61389176
85NME10.60900743
86CSNK1G30.60574072
87PAK10.60412293
88SIK30.58990391
89MAP3K50.58894952
90PRPF4B0.57431284
91MAPKAPK50.54853547
92CDK90.53672801
93RPS6KA50.51505242
94ZAP700.51362311
95YES10.50164694
96ZAK0.49184168
97IKBKE0.48807753
98BMPR20.47517963
99MELK0.47053175
100LIMK10.44507190
101PIK3CG0.42214674
102TEC0.40656446
103IRAK40.40061091
104ILK0.38868270
105DAPK30.38713847
106EIF2AK20.38536412
107FES0.38265209
108BLK0.37644525
109SYK0.36895383
110JAK30.36565774
111PBK0.36389600
112CSNK1A1L0.35813297
113DAPK10.35477705
114ITK0.35028214
115PRKCI0.34600067
116CSNK1G20.33676206
117TXK0.32665030
118MAP3K30.32352667
119ALK0.30923782
120MAP3K140.30529833
121RAF10.30471011
122ADRBK20.30199411
123WNK30.29884006
124TYK20.29231296
125BRD40.29144409
126CSNK1G10.29086832
127PDK20.26042348
128LYN0.24769776
129GRK60.24204894
130RPS6KA10.24174481
131PRKDC0.22947368
132MET0.22144674
133EPHA20.21528987
134NEK90.21276303
135LCK0.20138796
136CSNK1E0.19296814
137MAPK90.19264400
138MST40.18168219
139RPS6KC10.17666013
140RPS6KL10.17666013

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.22149533
2Mismatch repair_Homo sapiens_hsa034304.36758293
3Ribosome_Homo sapiens_hsa030103.80175317
4Proteasome_Homo sapiens_hsa030503.44322143
5* Spliceosome_Homo sapiens_hsa030403.39585448
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.36025277
7Base excision repair_Homo sapiens_hsa034103.28108265
8RNA polymerase_Homo sapiens_hsa030203.18611566
9Homologous recombination_Homo sapiens_hsa034403.13505078
10RNA transport_Homo sapiens_hsa030132.94639713
11Nucleotide excision repair_Homo sapiens_hsa034202.87217951
12Cell cycle_Homo sapiens_hsa041102.67803436
13One carbon pool by folate_Homo sapiens_hsa006702.59300699
14Pyrimidine metabolism_Homo sapiens_hsa002402.51008583
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.39371833
16Non-homologous end-joining_Homo sapiens_hsa034502.19662525
17Fanconi anemia pathway_Homo sapiens_hsa034602.14456060
18Basal transcription factors_Homo sapiens_hsa030222.02598154
19RNA degradation_Homo sapiens_hsa030181.87291660
20Fatty acid elongation_Homo sapiens_hsa000621.81004298
21mRNA surveillance pathway_Homo sapiens_hsa030151.62807769
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.56108529
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.44624451
24Purine metabolism_Homo sapiens_hsa002301.38380022
25p53 signaling pathway_Homo sapiens_hsa041151.38003253
26Propanoate metabolism_Homo sapiens_hsa006401.28690379
27Asthma_Homo sapiens_hsa053101.28603355
28Allograft rejection_Homo sapiens_hsa053301.27429880
29Epstein-Barr virus infection_Homo sapiens_hsa051691.24307463
30Systemic lupus erythematosus_Homo sapiens_hsa053221.23700725
31Rheumatoid arthritis_Homo sapiens_hsa053231.15906066
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.12162991
33Protein export_Homo sapiens_hsa030601.09460109
34Antigen processing and presentation_Homo sapiens_hsa046121.05981353
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.00953612
36Autoimmune thyroid disease_Homo sapiens_hsa053200.98151857
37Oocyte meiosis_Homo sapiens_hsa041140.96528089
38Pentose phosphate pathway_Homo sapiens_hsa000300.95072451
39Viral carcinogenesis_Homo sapiens_hsa052030.94317173
40Graft-versus-host disease_Homo sapiens_hsa053320.93417671
41Herpes simplex infection_Homo sapiens_hsa051680.90853850
42Sulfur metabolism_Homo sapiens_hsa009200.89644327
43Selenocompound metabolism_Homo sapiens_hsa004500.89524809
44Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.89229362
45Peroxisome_Homo sapiens_hsa041460.88644603
46Pyruvate metabolism_Homo sapiens_hsa006200.87363120
47Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87007566
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.84865848
49Cyanoamino acid metabolism_Homo sapiens_hsa004600.79849927
50Biosynthesis of amino acids_Homo sapiens_hsa012300.78244307
51Type I diabetes mellitus_Homo sapiens_hsa049400.77167239
52Cysteine and methionine metabolism_Homo sapiens_hsa002700.75892174
53Vitamin B6 metabolism_Homo sapiens_hsa007500.75703251
54Huntingtons disease_Homo sapiens_hsa050160.75174447
55Primary immunodeficiency_Homo sapiens_hsa053400.74284604
56HTLV-I infection_Homo sapiens_hsa051660.71287640
57Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.70890456
58Sulfur relay system_Homo sapiens_hsa041220.69499365
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.68639202
60Folate biosynthesis_Homo sapiens_hsa007900.66893767
61Steroid biosynthesis_Homo sapiens_hsa001000.66341919
62Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66029135
63Lysosome_Homo sapiens_hsa041420.63140653
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.62778110
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61845808
66Legionellosis_Homo sapiens_hsa051340.61350380
67Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.60640921
68Thyroid cancer_Homo sapiens_hsa052160.60629239
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.60509312
70Fatty acid metabolism_Homo sapiens_hsa012120.57964776
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.56071840
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.54624914
73Parkinsons disease_Homo sapiens_hsa050120.54342813
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52551282
75Toll-like receptor signaling pathway_Homo sapiens_hsa046200.52324717
76Alcoholism_Homo sapiens_hsa050340.51779442
77Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51616589
78Staphylococcus aureus infection_Homo sapiens_hsa051500.50344602
79Leishmaniasis_Homo sapiens_hsa051400.49652656
80Salmonella infection_Homo sapiens_hsa051320.49430451
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.49217376
82Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.47702340
83Measles_Homo sapiens_hsa051620.47025160
84Viral myocarditis_Homo sapiens_hsa054160.46718939
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46476273
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45423932
87African trypanosomiasis_Homo sapiens_hsa051430.45305430
88Fructose and mannose metabolism_Homo sapiens_hsa000510.44650138
89Oxidative phosphorylation_Homo sapiens_hsa001900.44178982
90N-Glycan biosynthesis_Homo sapiens_hsa005100.43624605
91Carbon metabolism_Homo sapiens_hsa012000.42842354
92NOD-like receptor signaling pathway_Homo sapiens_hsa046210.42610663
93Pertussis_Homo sapiens_hsa051330.42574437
94Malaria_Homo sapiens_hsa051440.41668070
95Apoptosis_Homo sapiens_hsa042100.41331255
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.39623899
97Transcriptional misregulation in cancer_Homo sapiens_hsa052020.39404329
98Small cell lung cancer_Homo sapiens_hsa052220.38510859
99Glutathione metabolism_Homo sapiens_hsa004800.38058871
100MicroRNAs in cancer_Homo sapiens_hsa052060.32628210
101Shigellosis_Homo sapiens_hsa051310.32595017
102Colorectal cancer_Homo sapiens_hsa052100.32378593
103Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31647746
104Hepatitis B_Homo sapiens_hsa051610.30426238
105Galactose metabolism_Homo sapiens_hsa000520.30178937
106Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.28579247
107Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.27172008
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.27106050
109Other glycan degradation_Homo sapiens_hsa005110.25897004
110Acute myeloid leukemia_Homo sapiens_hsa052210.25236530
111Regulation of autophagy_Homo sapiens_hsa041400.24349661
112Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.22842173
113Notch signaling pathway_Homo sapiens_hsa043300.21674086
114Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21385811
115NF-kappa B signaling pathway_Homo sapiens_hsa040640.21185525
116Metabolic pathways_Homo sapiens_hsa011000.21075351
117Hematopoietic cell lineage_Homo sapiens_hsa046400.20108301
118Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.19975843
119Chronic myeloid leukemia_Homo sapiens_hsa052200.18768354
120HIF-1 signaling pathway_Homo sapiens_hsa040660.18146005
121T cell receptor signaling pathway_Homo sapiens_hsa046600.17807737
122Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.17080468
123Bladder cancer_Homo sapiens_hsa052190.16079738
124Influenza A_Homo sapiens_hsa051640.16034091
125Basal cell carcinoma_Homo sapiens_hsa052170.14606043
126B cell receptor signaling pathway_Homo sapiens_hsa046620.12901403
127Hippo signaling pathway_Homo sapiens_hsa043900.12789399
128Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12173148
129Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.11351105
130Pathways in cancer_Homo sapiens_hsa052000.11240782
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.11205501
132RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.08741934
133Non-small cell lung cancer_Homo sapiens_hsa052230.07744323
134Intestinal immune network for IgA production_Homo sapiens_hsa046720.06881885
135Alzheimers disease_Homo sapiens_hsa050100.06778405
136TGF-beta signaling pathway_Homo sapiens_hsa043500.06348199
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.05353053

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