CTNND1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Armadillo protein family, which function in adhesion between cells and signal transduction. Multiple translation initiation codons and alternative splicing result in many different isoforms being translated. Not all of the full-length natures of the described transcript variants have been determined. Read-through transcription also exists between this gene and the neighboring upstream thioredoxin-related transmembrane protein 2 (TMX2) gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1hemidesmosome assembly (GO:0031581)4.43663052
2cell adhesion mediated by integrin (GO:0033627)3.99858845
3epithelial cell-cell adhesion (GO:0090136)3.86411732
4hippo signaling (GO:0035329)3.84179910
5bundle of His cell to Purkinje myocyte communication (GO:0086069)3.58206750
6regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.56032940
7regulation of hippo signaling (GO:0035330)3.39421892
8gap junction assembly (GO:0016264)3.36168035
9negative regulation of keratinocyte proliferation (GO:0010839)3.34404502
10basement membrane organization (GO:0071711)3.33098132
11desmosome organization (GO:0002934)3.32679541
12regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.31988015
13apoptotic cell clearance (GO:0043277)3.29638271
14chondrocyte proliferation (GO:0035988)3.27182850
15endodermal cell differentiation (GO:0035987)3.25071997
16endocardial cushion development (GO:0003197)3.24995798
17polarized epithelial cell differentiation (GO:0030859)3.21132450
18skin morphogenesis (GO:0043589)3.19313961
19cell-substrate junction assembly (GO:0007044)3.16784365
20paraxial mesoderm development (GO:0048339)3.13106119
21mesodermal cell differentiation (GO:0048333)3.12943305
22surfactant homeostasis (GO:0043129)3.12907851
23regulation of water loss via skin (GO:0033561)3.12001244
24cell migration involved in sprouting angiogenesis (GO:0002042)3.11540784
25retina vasculature morphogenesis in camera-type eye (GO:0061299)2.97893882
26renal filtration (GO:0097205)2.95681630
27vascular endothelial growth factor signaling pathway (GO:0038084)2.90088031
28cytoskeletal anchoring at plasma membrane (GO:0007016)2.89486165
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.88678316
30endothelial cell morphogenesis (GO:0001886)2.87392716
31multicellular organismal water homeostasis (GO:0050891)2.87206505
32dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.86943782
33collagen fibril organization (GO:0030199)2.86743911
34positive regulation of endothelial cell apoptotic process (GO:2000353)2.86725673
35COPII vesicle coating (GO:0048208)2.86567494
36wound healing, spreading of epidermal cells (GO:0035313)2.86374611
37positive regulation of SMAD protein import into nucleus (GO:0060391)2.86123753
38establishment of skin barrier (GO:0061436)2.84663590
39regulation of SMAD protein import into nucleus (GO:0060390)2.84216487
40insulin-like growth factor receptor signaling pathway (GO:0048009)2.81064277
41negative regulation of fatty acid transport (GO:2000192)2.80469104
42protein retention in ER lumen (GO:0006621)2.77839326
43regulation of cardioblast differentiation (GO:0051890)2.76803795
44axon extension involved in axon guidance (GO:0048846)2.73997449
45neuron projection extension involved in neuron projection guidance (GO:1902284)2.73997449
46adherens junction assembly (GO:0034333)2.73798010
47blood vessel endothelial cell migration (GO:0043534)2.73110259
48positive regulation of p38MAPK cascade (GO:1900745)2.72285837
49COPI coating of Golgi vesicle (GO:0048205)2.70133134
50Golgi transport vesicle coating (GO:0048200)2.70133134
51plasma membrane repair (GO:0001778)2.67067731
52protein heterotrimerization (GO:0070208)2.67003109
53epithelial cell differentiation involved in prostate gland development (GO:0060742)2.66308084
54renal system development (GO:0072001)2.66118054
55anterior/posterior axis specification, embryo (GO:0008595)2.66104359
56planar cell polarity pathway involved in neural tube closure (GO:0090179)2.65697685
57substrate adhesion-dependent cell spreading (GO:0034446)2.63810721
58branching involved in salivary gland morphogenesis (GO:0060445)2.63734856
59embryonic foregut morphogenesis (GO:0048617)2.63484724
60negative regulation of cell fate specification (GO:0009996)2.62788770
61retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.61654208
62apical protein localization (GO:0045176)2.60686789
63epoxygenase P450 pathway (GO:0019373)2.59090545
64regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.59015504
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.58727002
66intestinal epithelial cell development (GO:0060576)2.58480176
67regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.58300311
68establishment of apical/basal cell polarity (GO:0035089)2.57283217
69regulation of tight junction assembly (GO:2000810)2.56931113
70dorsal/ventral axis specification (GO:0009950)2.56915321
71establishment of planar polarity (GO:0001736)2.55761846
72establishment of tissue polarity (GO:0007164)2.55761846
73negative regulation of chondrocyte differentiation (GO:0032331)2.55518366
74gastrulation with mouth forming second (GO:0001702)2.54431992
75regulation of establishment of planar polarity (GO:0090175)2.53963465
76chemical homeostasis within a tissue (GO:0048875)2.53224047
77regulation of cholesterol homeostasis (GO:2000188)2.52533666
78embryonic retina morphogenesis in camera-type eye (GO:0060059)2.50917128
79low-density lipoprotein particle clearance (GO:0034383)2.50626163
80regulation of cell fate specification (GO:0042659)2.50577040
81atrioventricular valve morphogenesis (GO:0003181)2.49832076
82midgut development (GO:0007494)2.49689063
83cell-substrate adherens junction assembly (GO:0007045)2.49277707
84focal adhesion assembly (GO:0048041)2.49277707
85establishment or maintenance of apical/basal cell polarity (GO:0035088)2.48817543
86establishment or maintenance of bipolar cell polarity (GO:0061245)2.48817543
87branching involved in mammary gland duct morphogenesis (GO:0060444)2.48235758
88positive regulation of hormone biosynthetic process (GO:0046886)2.47881679
89barbed-end actin filament capping (GO:0051016)2.46560131
90establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.46355360
91vesicle coating (GO:0006901)2.46158420
92cell-cell junction assembly (GO:0007043)2.44363298
93keratinocyte proliferation (GO:0043616)2.43906568
94intestinal absorption (GO:0050892)2.42157315
95cellular response to vitamin D (GO:0071305)2.42016909
96regulation of keratinocyte proliferation (GO:0010837)2.41926346
97protein localization to endosome (GO:0036010)2.41530043
98growth hormone receptor signaling pathway (GO:0060396)2.41399332
99intestinal cholesterol absorption (GO:0030299)2.41307370
100cellular response to vitamin (GO:0071295)2.39297704
101protein localization to cell surface (GO:0034394)2.39269393
102extracellular matrix disassembly (GO:0022617)2.38108002
103ectoderm development (GO:0007398)2.37390594
104semaphorin-plexin signaling pathway (GO:0071526)2.33651565
105glomerular basement membrane development (GO:0032836)2.33382931
106water homeostasis (GO:0030104)2.32533312
107negative regulation of catenin import into nucleus (GO:0035414)2.32445642
108positive regulation of fatty acid beta-oxidation (GO:0032000)2.32395148
109coronary vasculature morphogenesis (GO:0060977)2.32383706
110glomerular epithelial cell development (GO:0072310)2.32154066
111endothelial cell chemotaxis (GO:0035767)2.31833038
112stress fiber assembly (GO:0043149)2.31794761
113lymphangiogenesis (GO:0001946)2.31252393
114regulation of p38MAPK cascade (GO:1900744)2.30937559
115glomerular visceral epithelial cell development (GO:0072015)2.30540385
116tight junction assembly (GO:0070830)2.29272756
117cytoplasmic mRNA processing body assembly (GO:0033962)2.28049295
118asymmetric protein localization (GO:0008105)2.27584774
119regulation of transforming growth factor beta2 production (GO:0032909)2.26979970
120wound healing, spreading of cells (GO:0044319)2.26349750
121negative regulation of fibrinolysis (GO:0051918)2.25644803
122regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.25173455
123multicellular organismal macromolecule metabolic process (GO:0044259)2.25153099
124regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.25024612
125G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.24606765
126glomerular filtration (GO:0003094)2.24511203
127positive regulation of epithelial to mesenchymal transition (GO:0010718)2.24295035
128collagen metabolic process (GO:0032963)2.24113057
129hormone catabolic process (GO:0042447)2.24030042
130positive regulation of hormone metabolic process (GO:0032352)2.22840168
131notochord development (GO:0030903)2.22659833
132cell surface receptor signaling pathway involved in heart development (GO:0061311)2.22613024
133cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.22380991
134non-canonical Wnt signaling pathway (GO:0035567)2.21916362
135multicellular organismal metabolic process (GO:0044236)2.21651476
136multicellular organismal catabolic process (GO:0044243)2.20678248
137regulation of catenin import into nucleus (GO:0035412)2.20603966
138convergent extension (GO:0060026)2.17345643
139lung lobe morphogenesis (GO:0060463)2.16776673
140regulation of transforming growth factor beta1 production (GO:0032908)2.15670185
141renal system process involved in regulation of blood volume (GO:0001977)2.15024185
142* cell junction assembly (GO:0034329)2.14274080
143regulation of Wnt signaling pathway involved in heart development (GO:0003307)2.12188617
144keratinocyte differentiation (GO:0030216)2.11166569
145* cell junction organization (GO:0034330)2.08596120
146cell-cell junction maintenance (GO:0045217)2.08577896
147actin filament depolymerization (GO:0030042)2.08527485
148morphogenesis of an epithelial sheet (GO:0002011)2.06265217
149* adherens junction organization (GO:0034332)2.06101617
150regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.05836320

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human7.07879597
2TRIM28_21343339_ChIP-Seq_HEK293_Human3.71535102
3NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.33845494
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.13357765
5CLOCK_20551151_ChIP-Seq_293T_Human3.02765311
6RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98054989
7ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.54907855
8ESR1_21235772_ChIP-Seq_MCF-7_Human2.44292364
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.31794820
10ESR2_21235772_ChIP-Seq_MCF-7_Human2.26170587
11SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.23650242
12HIF1A_21447827_ChIP-Seq_MCF-7_Human2.18347514
13PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.09969461
14STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.09430521
15RXR_22158963_ChIP-Seq_LIVER_Mouse2.07176224
16LXR_22158963_ChIP-Seq_LIVER_Mouse2.06033853
17PPARA_22158963_ChIP-Seq_LIVER_Mouse2.02908405
18FOXO3_23340844_ChIP-Seq_DLD1_Human2.01206746
19* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.97729825
20NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.97229871
21ZNF263_19887448_ChIP-Seq_K562_Human1.90728419
22PPAR_26484153_Chip-Seq_NCI-H1993_Human1.89667327
23SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.89322397
24TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.86539415
25* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.80608166
26SALL4_18804426_ChIP-ChIP_XEN_Mouse1.78041938
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.77158014
28* SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.76843377
29* SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.76843377
30RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.74227987
31NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.72610590
32CDX2_20551321_ChIP-Seq_CACO-2_Human1.69144445
33SOX9_24532713_ChIP-Seq_HFSC_Mouse1.67968746
34SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.65055406
35ZNF217_24962896_ChIP-Seq_MCF-7_Human1.64613256
36ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.63002762
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.61175522
38ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.60494395
39CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.59671695
40* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.56114037
41* CJUN_26792858_Chip-Seq_BT549_Human1.55476717
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.55095243
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.53825485
44GATA6_25053715_ChIP-Seq_YYC3_Human1.53170707
45* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.53005151
46ATF3_27146783_Chip-Seq_COLON_Human1.52425331
47SOX2_20726797_ChIP-Seq_SW620_Human1.51294588
48EP300_21415370_ChIP-Seq_HL-1_Mouse1.49238185
49GATA4_25053715_ChIP-Seq_YYC3_Human1.47848551
50RACK7_27058665_Chip-Seq_MCF-7_Human1.47043530
51WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.46400748
52BRD4_25478319_ChIP-Seq_HGPS_Human1.45339471
53ELK3_25401928_ChIP-Seq_HUVEC_Human1.43594851
54ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.43565402
55TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.43039976
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.43010862
57* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.42853803
58ESR1_15608294_ChIP-ChIP_MCF-7_Human1.41923136
59TCF3_18692474_ChIP-Seq_MEFs_Mouse1.39761849
60POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.36467263
61ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.34500677
62RUNX1_27514584_Chip-Seq_MCF-7_Human1.33506858
63WT1_19549856_ChIP-ChIP_CCG9911_Human1.32390938
64KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.31063159
65KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.31063159
66KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.31063159
67TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.30795526
68AR_21909140_ChIP-Seq_LNCAP_Human1.30207629
69* FOXA2_19822575_ChIP-Seq_HepG2_Human1.28147042
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.26577302
71UBF1/2_26484160_Chip-Seq_HMECs_Human1.24136462
72TBX20_22080862_ChIP-Seq_HEART_Mouse1.23267400
73TBX20_22328084_ChIP-Seq_HEART_Mouse1.23267400
74PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22938404
75GATA2_21666600_ChIP-Seq_HMVEC_Human1.22749143
76* ISL1_27105846_Chip-Seq_CPCs_Mouse1.21543383
77FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.20734426
78CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.17925389
79FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.17683119
80EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.17529595
81ARNT_22903824_ChIP-Seq_MCF-7_Human1.17287801
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17201042
83P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16319528
84NFIB_24661679_ChIP-Seq_LUNG_Mouse1.15524001
85* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.15340924
86ZFP281_18757296_ChIP-ChIP_E14_Mouse1.13905290
87TCF4_18268006_ChIP-ChIP_LS174T_Human1.13805643
88KLF5_25053715_ChIP-Seq_YYC3_Human1.13728968
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.12673424
90CDX2_19796622_ChIP-Seq_MESCs_Mouse1.11954174
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11747367
92JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11605626
93TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11584393
94EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10266926
95FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.09258716
96AHR_22903824_ChIP-Seq_MCF-7_Human1.09113446
97ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08615115
98ZFP281_27345836_Chip-Seq_ESCs_Mouse1.07210269
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06641958
100PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06067259
101FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.04844908
102ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03967142
103FOXM1_23109430_ChIP-Seq_U2OS_Human1.03808247
104FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03420639
105WT1_25993318_ChIP-Seq_PODOCYTE_Human1.02936648
106TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.02647788
107GATA3_24758297_ChIP-Seq_MCF-7_Human1.02452789
108SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.01988927
109* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01008402
110* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01008402
111PIAS1_25552417_ChIP-Seq_VCAP_Human0.99993931
112FOXM1_26456572_ChIP-Seq_MCF-7_Human0.99525195
113PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.99378075
114KDM2B_26808549_Chip-Seq_K562_Human0.98296949
115UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.95111611
116NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94122946
117TP63_23658742_ChIP-Seq_EP156T_Human0.93946196
118TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.92785054

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.37640949
2MP0008438_abnormal_cutaneous_collagen3.62395813
3MP0005275_abnormal_skin_tensile3.06628037
4MP0010234_abnormal_vibrissa_follicle3.06152115
5MP0000566_synostosis3.01610493
6MP0004272_abnormal_basement_membrane2.96407561
7MP0010352_gastrointestinal_tract_polyps2.69953663
8MP0003566_abnormal_cell_adhesion2.50313253
9MP0005409_darkened_coat_color2.46133196
10MP0000537_abnormal_urethra_morphology2.38968788
11MP0009384_cardiac_valve_regurgitation2.05135679
12MP0009053_abnormal_anal_canal2.00814852
13MP0006054_spinal_hemorrhage1.99692118
14MP0005623_abnormal_meninges_morphology1.89161363
15MP0003300_gastrointestinal_ulcer1.82817986
16MP0004264_abnormal_extraembryonic_tissu1.80051102
17MP0010368_abnormal_lymphatic_system1.78192702
18MP0004858_abnormal_nervous_system1.73889484
19MP0005076_abnormal_cell_differentiation1.72662880
20MP0001849_ear_inflammation1.71276168
21MP0005503_abnormal_tendon_morphology1.70231178
22MP0004782_abnormal_surfactant_physiolog1.67212516
23MP0005360_urolithiasis1.67193493
24MP0005023_abnormal_wound_healing1.65142455
25MP0003941_abnormal_skin_development1.60483549
26MP0003279_aneurysm1.57686177
27MP0003252_abnormal_bile_duct1.56732655
28MP0002060_abnormal_skin_morphology1.56134593
29MP0010678_abnormal_skin_adnexa1.55978431
30MP0001958_emphysema1.53786254
31MP0010030_abnormal_orbit_morphology1.52653868
32MP0002796_impaired_skin_barrier1.46594194
33MP0000733_abnormal_muscle_development1.40782664
34MP0005248_abnormal_Harderian_gland1.40635425
35MP0003950_abnormal_plasma_membrane1.39998524
36MP0002896_abnormal_bone_mineralization1.35380217
37MP0003091_abnormal_cell_migration1.33607079
38MP0005257_abnormal_intraocular_pressure1.32348562
39MP0002139_abnormal_hepatobiliary_system1.32240973
40MP0003283_abnormal_digestive_organ1.29820025
41MP0003453_abnormal_keratinocyte_physiol1.29611698
42MP0003868_abnormal_feces_composition1.29515705
43MP0003115_abnormal_respiratory_system1.25741771
44MP0002877_abnormal_melanocyte_morpholog1.25026181
45MP0003385_abnormal_body_wall1.24678422
46MP0000516_abnormal_urinary_system1.24248613
47MP0005367_renal/urinary_system_phenotyp1.24248613
48MP0004185_abnormal_adipocyte_glucose1.20958109
49MP0000383_abnormal_hair_follicle1.20714493
50MP0002254_reproductive_system_inflammat1.20325632
51MP0000767_abnormal_smooth_muscle1.20208879
52MP0001666_abnormal_nutrient_absorption1.17837868
53MP0005508_abnormal_skeleton_morphology1.15604742
54MP0000534_abnormal_ureter_morphology1.14904746
55MP0000462_abnormal_digestive_system1.14790673
56MP0003045_fibrosis1.09925593
57MP0002098_abnormal_vibrissa_morphology1.08428335
58MP0001879_abnormal_lymphatic_vessel1.04646756
59MP0000579_abnormal_nail_morphology1.04522792
60MP0005187_abnormal_penis_morphology1.04231468
61MP0000467_abnormal_esophagus_morphology1.03078155
62MP0005085_abnormal_gallbladder_physiolo1.02690292
63MP0002295_abnormal_pulmonary_circulatio1.02375479
64MP0002282_abnormal_trachea_morphology0.99520929
65MP0000428_abnormal_craniofacial_morphol0.99448233
66MP0002925_abnormal_cardiovascular_devel0.98744817
67MP0004084_abnormal_cardiac_muscle0.98593802
68MP0005501_abnormal_skin_physiology0.98135877
69MP0003942_abnormal_urinary_system0.97952913
70MP0003937_abnormal_limbs/digits/tail_de0.97893504
71MP0003315_abnormal_perineum_morphology0.96866347
72MP0004197_abnormal_fetal_growth/weight/0.96303158
73MP0000762_abnormal_tongue_morphology0.95890913
74MP0002086_abnormal_extraembryonic_tissu0.94572664
75MP0003935_abnormal_craniofacial_develop0.94557481
76MP0009840_abnormal_foam_cell0.94085173
77MP0003567_abnormal_fetal_cardiomyocyte0.93394580
78MP0000678_abnormal_parathyroid_gland0.93313278
79MP0010630_abnormal_cardiac_muscle0.92073100
80MP0005365_abnormal_bile_salt0.91978075
81MP0002697_abnormal_eye_size0.91864267
82MP0000627_abnormal_mammary_gland0.91863421
83MP0002089_abnormal_postnatal_growth/wei0.91806781
84MP0003119_abnormal_digestive_system0.91590165
85MP0001915_intracranial_hemorrhage0.90916550
86MP0006138_congestive_heart_failure0.90527838
87MP0010771_integument_phenotype0.90132045
88MP0004233_abnormal_muscle_weight0.87460023
89MP0002168_other_aberrant_phenotype0.87194100
90MP0000432_abnormal_head_morphology0.86142254
91MP0000377_abnormal_hair_follicle0.85708087
92MP0004019_abnormal_vitamin_homeostasis0.85471670
93MP0003878_abnormal_ear_physiology0.84420811
94MP0005377_hearing/vestibular/ear_phenot0.84420811
95MP0001299_abnormal_eye_distance/0.83611431
96MP0002088_abnormal_embryonic_growth/wei0.83321379
97MP0005167_abnormal_blood-brain_barrier0.83273208
98MP0001614_abnormal_blood_vessel0.83038379
99MP0002084_abnormal_developmental_patter0.81772461
100MP0003984_embryonic_growth_retardation0.81516154
101MP0002233_abnormal_nose_morphology0.80987660
102MP0001243_abnormal_dermal_layer0.80814000
103MP0003890_abnormal_embryonic-extraembry0.79960827
104MP0003755_abnormal_palate_morphology0.79638595
105MP0009780_abnormal_chondrocyte_physiolo0.79492108
106MP0002111_abnormal_tail_morphology0.79255365
107MP0001730_embryonic_growth_arrest0.78445257
108MP0002128_abnormal_blood_circulation0.78345255
109MP0000163_abnormal_cartilage_morphology0.78041838
110* MP0001216_abnormal_epidermal_layer0.77264752
111MP0009250_abnormal_appendicular_skeleto0.76768843
112MP0002092_abnormal_eye_morphology0.76606418
113MP0009278_abnormal_bone_marrow0.76502435
114MP0002249_abnormal_larynx_morphology0.76328146
115MP0002932_abnormal_joint_morphology0.75871604
116MP0002085_abnormal_embryonic_tissue0.75524406
117MP0000003_abnormal_adipose_tissue0.75470421
118MP0001672_abnormal_embryogenesis/_devel0.74801056
119MP0002108_abnormal_muscle_morphology0.74150502
120MP0005380_embryogenesis_phenotype0.72832039
121MP0009672_abnormal_birth_weight0.72599916
122MP0005197_abnormal_uvea_morphology0.72479399
123MP0000477_abnormal_intestine_morphology0.71995948
124MP0005666_abnormal_adipose_tissue0.69813937
125MP0003191_abnormal_cellular_cholesterol0.68342788

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)4.63378084
2Premature rupture of membranes (HP:0001788)4.13502992
3Right ventricular cardiomyopathy (HP:0011663)4.09099935
4Atrophic scars (HP:0001075)3.93661914
5Shallow orbits (HP:0000586)3.84961696
6Cerebral aneurysm (HP:0004944)3.41242262
7Ankle contracture (HP:0006466)3.34702272
8Aortic aneurysm (HP:0004942)3.11610818
9Aortic dissection (HP:0002647)3.06758145
10Broad metatarsal (HP:0001783)2.84017552
11Cervical subluxation (HP:0003308)2.74756732
12Mitral valve prolapse (HP:0001634)2.67852930
13Milia (HP:0001056)2.66862848
14Fragile skin (HP:0001030)2.66103125
15Aneurysm (HP:0002617)2.60375529
16Peritonitis (HP:0002586)2.54915087
17Rectal prolapse (HP:0002035)2.52365687
18Increased connective tissue (HP:0009025)2.43521479
19Hyperactive renin-angiotensin system (HP:0000841)2.41815641
20Subacute progressive viral hepatitis (HP:0006572)2.41272601
21Abnormality of carpal bone ossification (HP:0006257)2.38634926
22Bladder diverticulum (HP:0000015)2.35968771
23Natal tooth (HP:0000695)2.34469611
24Dilatation of the ascending aorta (HP:0005111)2.26509988
25Esophageal varix (HP:0002040)2.24252131
26Lymphangioma (HP:0100764)2.23719804
27Focal segmental glomerulosclerosis (HP:0000097)2.19326449
28Osteolytic defects of the hand bones (HP:0009699)2.18022506
29Osteolytic defects of the phalanges of the hand (HP:0009771)2.18022506
30Abnormal ossification of hand bones (HP:0005921)2.17804181
31Thin bony cortex (HP:0002753)2.16185526
32Mildly elevated creatine phosphokinase (HP:0008180)2.13359445
33Flat acetabular roof (HP:0003180)2.13080862
34Hematochezia (HP:0002573)2.12844957
35Short 4th metacarpal (HP:0010044)2.11386692
36Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.11386692
37Blue sclerae (HP:0000592)2.09627032
38Deep venous thrombosis (HP:0002625)2.08853791
39Abnormality of nail color (HP:0100643)2.07931009
40Genu recurvatum (HP:0002816)2.07076430
41Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04166921
42Ulnar bowing (HP:0003031)2.02451004
43Vascular tortuosity (HP:0004948)2.01577529
44Spinal rigidity (HP:0003306)2.00786693
45Alopecia of scalp (HP:0002293)1.99685498
46Intrahepatic cholestasis (HP:0001406)1.99369249
47Soft skin (HP:0000977)1.97882994
48Abnormal hand bone ossification (HP:0010660)1.97184560
49Aplasia involving bones of the extremities (HP:0009825)1.95553886
50Aplasia involving bones of the upper limbs (HP:0009823)1.95553886
51Aplasia of the phalanges of the hand (HP:0009802)1.95553886
52Wormian bones (HP:0002645)1.92644883
53Abnormality of the 4th metacarpal (HP:0010012)1.92390745
54Ankyloglossia (HP:0010296)1.92152636
55Hypoplastic ischia (HP:0003175)1.90459114
56Arterial tortuosity (HP:0005116)1.89868525
57Abnormality of the distal phalanx of the thumb (HP:0009617)1.89815467
58Camptodactyly of toe (HP:0001836)1.89437493
59Turricephaly (HP:0000262)1.88273079
60Tibial bowing (HP:0002982)1.87732609
61Wrist flexion contracture (HP:0001239)1.87655968
62Lip pit (HP:0100267)1.87276366
63Deviation of the hallux (HP:0010051)1.87038767
64Neonatal short-limb short stature (HP:0008921)1.86751109
65Broad face (HP:0000283)1.84742974
66Hyporeflexia of lower limbs (HP:0002600)1.84625732
67Buphthalmos (HP:0000557)1.84539351
68Coronal craniosynostosis (HP:0004440)1.84528939
69Abnormality of permanent molar morphology (HP:0011071)1.84363642
70Abnormality of the dental root (HP:0006486)1.84363642
71Taurodontia (HP:0000679)1.84363642
72Distal upper limb amyotrophy (HP:0007149)1.83683146
73Upper limb amyotrophy (HP:0009129)1.83683146
74Abnormality of molar morphology (HP:0011070)1.83176643
75Abnormality of molar (HP:0011077)1.83176643
76Vertebral arch anomaly (HP:0008438)1.83036613
77Micronodular cirrhosis (HP:0001413)1.79050699
78Malnutrition (HP:0004395)1.78261817
79Type 1 muscle fiber predominance (HP:0003803)1.78104566
80Hallux valgus (HP:0001822)1.78034611
81Glomerulosclerosis (HP:0000096)1.77750329
82Hyperextensible skin (HP:0000974)1.77646860
83Abnormality of the salivary glands (HP:0010286)1.77607000
84Hyperacusis (HP:0010780)1.77448630
85Onycholysis (HP:0001806)1.76066219
86Back pain (HP:0003418)1.75695170
87Absent eyelashes (HP:0000561)1.75457461
88Bronchomalacia (HP:0002780)1.75184143
89Cardiovascular calcification (HP:0011915)1.74161645
90Follicular hyperkeratosis (HP:0007502)1.72990712
91Popliteal pterygium (HP:0009756)1.71510569
92Scapular winging (HP:0003691)1.70503573
93Abnormality of the ischium (HP:0003174)1.69403758
94Wide anterior fontanel (HP:0000260)1.68844191
95Hand muscle atrophy (HP:0009130)1.68505007
96Curly hair (HP:0002212)1.68301759
97Hemangiomatosis (HP:0007461)1.66911748
98Plantar hyperkeratosis (HP:0007556)1.66744542
99Abnormality of the acetabulum (HP:0003170)1.66573374
100Abnormal tarsal ossification (HP:0008369)1.64206897
101Abnormal vertebral ossification (HP:0100569)1.64147638
102Vascular calcification (HP:0004934)1.63595805
103Advanced eruption of teeth (HP:0006288)1.63461125
104Abnormality of the dental pulp (HP:0006479)1.63426650
105Short nail (HP:0001799)1.63399406
106Vertebral clefting (HP:0008428)1.63250203
107Radial bowing (HP:0002986)1.63212140
108Abnormality of proline metabolism (HP:0010907)1.63124660
109Hydroxyprolinuria (HP:0003080)1.63124660
110Arnold-Chiari malformation (HP:0002308)1.62822182
111Overgrowth (HP:0001548)1.62706838
112Enlarged penis (HP:0000040)1.62010521
113Asymmetry of the thorax (HP:0001555)1.60526273
114Long toe (HP:0010511)1.60500155
115Bowel diverticulosis (HP:0005222)1.60438769
116Abnormality of the gastric mucosa (HP:0004295)1.60288941
117Gastrointestinal carcinoma (HP:0002672)1.59570655
118Malignant gastrointestinal tract tumors (HP:0006749)1.59570655
119Bowed forearm bones (HP:0003956)1.59221559
120Bowing of the arm (HP:0006488)1.59221559
121Exostoses (HP:0100777)1.59114043
122Pili torti (HP:0003777)1.58984587
123Hemorrhage of the eye (HP:0011885)1.58450174
124Abnormal hair laboratory examination (HP:0003328)1.58279610
125Abnormality of dentin (HP:0010299)1.58241301
126Palmoplantar hyperkeratosis (HP:0000972)1.58235422
127Abnormality of the nasal septum (HP:0000419)1.57428320
128Woolly hair (HP:0002224)1.57017817
129Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.56441628
130Vertebral hypoplasia (HP:0008417)1.56441628
131Abnormality of complement system (HP:0005339)1.55974912
132Tarsal synostosis (HP:0008368)1.55868607
133Abnormality of the distal phalanges of the toes (HP:0010182)1.55506479
134Complement deficiency (HP:0004431)1.55459251
135Pterygium (HP:0001059)1.55187568
136Spinal cord compression (HP:0002176)1.54503203
137Short hallux (HP:0010109)1.54215071
138Skin nodule (HP:0200036)1.53972988
139Visceral angiomatosis (HP:0100761)1.53658616
140Cupped ribs (HP:0000887)1.53465268
141Spastic diplegia (HP:0001264)1.53370754
142Hypoplastic labia majora (HP:0000059)1.53172584
143Distal lower limb amyotrophy (HP:0008944)1.52433236
144Elbow flexion contracture (HP:0002987)1.52378286
145Palmar hyperkeratosis (HP:0010765)1.52307237
146Knee flexion contracture (HP:0006380)1.52223355
147Disproportionate tall stature (HP:0001519)1.52041957
148Neonatal death (HP:0003811)1.51961636

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS14.22758769
2EPHA23.51458360
3TRIB33.27719541
4DDR22.71038476
5RIPK12.69066917
6PKN22.66129337
7TTN2.49228431
8PDGFRA2.44918017
9PTK62.35613553
10ERN12.21298016
11CDK122.18675308
12MET2.10659385
13EPHB22.10485797
14SIK12.05639619
15FRK1.99679340
16FER1.89271032
17PTK21.85302206
18LATS21.75131369
19MST1R1.73618597
20STK31.71366959
21PAK41.61536181
22SMG11.44968776
23PAK21.44364113
24TGFBR21.42627380
25CAMK1D1.38293016
26BMX1.35792901
27CDK61.35487392
28LRRK21.34807346
29DMPK1.33681217
30EEF2K1.31386624
31STK101.30460220
32MAP3K101.29575485
33MTOR1.29319910
34STK241.23898371
35STK38L1.21666915
36EPHB11.20197233
37MAP3K21.16366182
38FGFR11.12861328
39PDGFRB1.12813088
40LMTK21.11872474
41STK391.08343237
42RPS6KB21.08167701
43ICK1.07316595
44MAP3K31.02664056
45PAK30.99156629
46CAMK1G0.98389751
47FGFR40.94152191
48FGFR20.94057459
49MAP2K20.93615278
50TESK10.92839517
51TIE10.91953353
52ERBB20.91433889
53TRPM70.91091040
54EPHA30.90906732
55BCR0.89749062
56PIK3CA0.86066958
57NEK90.85211930
58SCYL20.84357611
59TGFBR10.83271763
60AKT30.78206273
61KDR0.77145006
62NEK10.74438716
63ERBB40.74269728
64DYRK1B0.73529631
65MAP3K80.72695292
66FLT30.71593726
67RET0.70918317
68STK380.70669206
69MAP2K10.70148381
70NUAK10.69126970
71PNCK0.68736228
72SGK30.66235571
73ROCK10.62032878
74PRKG20.61952190
75RPS6KA20.61629994
76GSK3A0.61226096
77FGFR30.60721117
78MAPKAPK30.58964502
79RPS6KA40.57987583
80PBK0.57727543
81MAP3K90.57031644
82TSSK60.56730035
83CASK0.55781985
84SGK2230.53851944
85SGK4940.53851944
86ROCK20.53717991
87MST40.53245935
88MYLK0.52470125
89MAP3K60.50654121
90PRKD10.50288050
91NEK60.47689731
92ILK0.47343962
93KSR10.46610127
94YES10.46007708
95PTK2B0.45278582
96LIMK10.44271180
97TYRO30.44046590
98CDC42BPA0.43500731
99MAPK150.43320514
100NTRK10.43076588
101MARK20.42657012
102BRD40.42006367
103PRKD20.40982805
104SGK20.40331612
105WNK40.39808948
106PRKD30.39439308
107BRSK20.38611633
108MAP2K30.38611161
109INSR0.37241860
110CDK90.37029365
111KSR20.36374559
112CHUK0.36030528
113MELK0.34880232
114TTK0.33039130
115TNIK0.32798274
116AKT20.32655518
117MAP3K70.31665623
118PIK3CG0.31663220
119* SRC0.30962806
120PRKAA10.30043796
121WNK10.29943558
122ALK0.29524831
123PRKAA20.29268682
124PRKCI0.28744728
125CDK70.28229866
126CSNK1A1L0.27822279

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.76661663
2Nitrogen metabolism_Homo sapiens_hsa009102.36074653
3* Adherens junction_Homo sapiens_hsa045202.29194363
4Focal adhesion_Homo sapiens_hsa045102.11572113
5Cyanoamino acid metabolism_Homo sapiens_hsa004601.89768312
6Small cell lung cancer_Homo sapiens_hsa052221.85111298
7Proteoglycans in cancer_Homo sapiens_hsa052051.84218977
8Hippo signaling pathway_Homo sapiens_hsa043901.82445649
9Bladder cancer_Homo sapiens_hsa052191.76232788
10Protein digestion and absorption_Homo sapiens_hsa049741.73787971
11Fat digestion and absorption_Homo sapiens_hsa049751.72935567
12Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.71860502
13Amoebiasis_Homo sapiens_hsa051461.69768813
14Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.68987452
15Tight junction_Homo sapiens_hsa045301.65878059
16Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.58260984
17Basal cell carcinoma_Homo sapiens_hsa052171.57768501
18TGF-beta signaling pathway_Homo sapiens_hsa043501.46341850
19Lysine degradation_Homo sapiens_hsa003101.39314632
20MicroRNAs in cancer_Homo sapiens_hsa052061.37885172
21Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.33577411
22Phenylalanine metabolism_Homo sapiens_hsa003601.32723346
23PPAR signaling pathway_Homo sapiens_hsa033201.26875074
24Caffeine metabolism_Homo sapiens_hsa002321.26264373
25Fatty acid degradation_Homo sapiens_hsa000711.25649297
26Arginine biosynthesis_Homo sapiens_hsa002201.24505710
27Complement and coagulation cascades_Homo sapiens_hsa046101.24150018
28Bile secretion_Homo sapiens_hsa049761.23843843
29Renin-angiotensin system_Homo sapiens_hsa046141.23723475
30* Leukocyte transendothelial migration_Homo sapiens_hsa046701.16453141
31Chronic myeloid leukemia_Homo sapiens_hsa052201.15624980
32Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.15274742
33Sulfur metabolism_Homo sapiens_hsa009201.14686355
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.13327135
35Tryptophan metabolism_Homo sapiens_hsa003801.13310958
36Fructose and mannose metabolism_Homo sapiens_hsa000511.12977717
37Hedgehog signaling pathway_Homo sapiens_hsa043401.09077528
38Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08297082
39Mineral absorption_Homo sapiens_hsa049781.06999044
40Dilated cardiomyopathy_Homo sapiens_hsa054141.06752140
41Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.04005419
42Endometrial cancer_Homo sapiens_hsa052131.00918167
43Insulin resistance_Homo sapiens_hsa049310.98457951
44Arginine and proline metabolism_Homo sapiens_hsa003300.98252464
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98124225
46Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97281358
47Sphingolipid metabolism_Homo sapiens_hsa006000.94513998
48Selenocompound metabolism_Homo sapiens_hsa004500.94476524
49Starch and sucrose metabolism_Homo sapiens_hsa005000.93906567
50Regulation of actin cytoskeleton_Homo sapiens_hsa048100.93327701
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.93276482
52Thyroid cancer_Homo sapiens_hsa052160.93249791
53Prostate cancer_Homo sapiens_hsa052150.93192424
54Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.92492393
55Vitamin digestion and absorption_Homo sapiens_hsa049770.90786216
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.90365891
57Fatty acid metabolism_Homo sapiens_hsa012120.87846670
58Notch signaling pathway_Homo sapiens_hsa043300.86032221
59PI3K-Akt signaling pathway_Homo sapiens_hsa041510.85074704
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.83611253
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.83184620
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.82979273
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.82950350
64Toxoplasmosis_Homo sapiens_hsa051450.82777384
65Prion diseases_Homo sapiens_hsa050200.82475370
66Chemical carcinogenesis_Homo sapiens_hsa052040.82323284
67mTOR signaling pathway_Homo sapiens_hsa041500.82082547
68Tyrosine metabolism_Homo sapiens_hsa003500.81337649
69Pathways in cancer_Homo sapiens_hsa052000.81076472
70Viral myocarditis_Homo sapiens_hsa054160.80476198
71Melanoma_Homo sapiens_hsa052180.80291876
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.79931346
732-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.78461836
74Dorso-ventral axis formation_Homo sapiens_hsa043200.78369728
75Pancreatic cancer_Homo sapiens_hsa052120.78139999
76Maturity onset diabetes of the young_Homo sapiens_hsa049500.78027200
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76824098
78ErbB signaling pathway_Homo sapiens_hsa040120.72881264
79Renal cell carcinoma_Homo sapiens_hsa052110.72304124
80Other glycan degradation_Homo sapiens_hsa005110.72236382
81Histidine metabolism_Homo sapiens_hsa003400.71090040
82Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69904081
83Gap junction_Homo sapiens_hsa045400.69009616
84Pancreatic secretion_Homo sapiens_hsa049720.68460965
85AMPK signaling pathway_Homo sapiens_hsa041520.68346013
86Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.68090129
87Fatty acid biosynthesis_Homo sapiens_hsa000610.67303522
88Choline metabolism in cancer_Homo sapiens_hsa052310.66996348
89Biosynthesis of amino acids_Homo sapiens_hsa012300.66111236
90Steroid biosynthesis_Homo sapiens_hsa001000.63819845
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62596057
92Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62271575
93Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.62224155
94Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.61625086
95Vibrio cholerae infection_Homo sapiens_hsa051100.59412262
96Wnt signaling pathway_Homo sapiens_hsa043100.58302624
97Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57570123
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.57495117
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.57344384
100* Rap1 signaling pathway_Homo sapiens_hsa040150.57177696
101Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56118035
102Colorectal cancer_Homo sapiens_hsa052100.54687443
103Glioma_Homo sapiens_hsa052140.53601533
104Glucagon signaling pathway_Homo sapiens_hsa049220.53134641
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.52206458
106ABC transporters_Homo sapiens_hsa020100.52160383
107Circadian rhythm_Homo sapiens_hsa047100.52045948
108Inositol phosphate metabolism_Homo sapiens_hsa005620.50656904
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.50567882
110Hepatitis C_Homo sapiens_hsa051600.50293862
111p53 signaling pathway_Homo sapiens_hsa041150.50182577
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49944424
113Platelet activation_Homo sapiens_hsa046110.48791433
114Staphylococcus aureus infection_Homo sapiens_hsa051500.48514814
115Galactose metabolism_Homo sapiens_hsa000520.48172117
116Longevity regulating pathway - mammal_Homo sapiens_hsa042110.48166316
117Thyroid hormone synthesis_Homo sapiens_hsa049180.47906597
118Axon guidance_Homo sapiens_hsa043600.47836823
119Melanogenesis_Homo sapiens_hsa049160.47169465
120Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.46823189
121Insulin signaling pathway_Homo sapiens_hsa049100.46042342
122HIF-1 signaling pathway_Homo sapiens_hsa040660.44071285
123Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44053547
124Retinol metabolism_Homo sapiens_hsa008300.43359384
125FoxO signaling pathway_Homo sapiens_hsa040680.42335608
126Estrogen signaling pathway_Homo sapiens_hsa049150.42191540
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41957861
128Lysosome_Homo sapiens_hsa041420.41845567

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