CTNND2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1vocalization behavior (GO:0071625)5.82142994
2neuron cell-cell adhesion (GO:0007158)5.51070265
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.43892261
4regulation of short-term neuronal synaptic plasticity (GO:0048172)5.40243138
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.33205047
6synaptic vesicle exocytosis (GO:0016079)5.32146912
7regulation of glutamate receptor signaling pathway (GO:1900449)4.93766224
8protein localization to synapse (GO:0035418)4.90752571
9glutamate secretion (GO:0014047)4.84475699
10locomotory exploration behavior (GO:0035641)4.82943665
11axon ensheathment in central nervous system (GO:0032291)4.78687006
12central nervous system myelination (GO:0022010)4.78687006
13synaptic vesicle maturation (GO:0016188)4.72988735
14ionotropic glutamate receptor signaling pathway (GO:0035235)4.72427999
15regulation of synaptic vesicle exocytosis (GO:2000300)4.61909393
16positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.60408599
17neurotransmitter-gated ion channel clustering (GO:0072578)4.57513157
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.43002861
19glutamate receptor signaling pathway (GO:0007215)4.36407489
20synaptic vesicle docking involved in exocytosis (GO:0016081)4.26094424
21sodium ion export (GO:0071436)4.24432011
22synaptic transmission, glutamatergic (GO:0035249)4.22307386
23neuronal action potential propagation (GO:0019227)4.22269529
24L-amino acid import (GO:0043092)4.16166553
25neurotransmitter secretion (GO:0007269)4.16081444
26postsynaptic membrane organization (GO:0001941)4.14441357
27presynaptic membrane assembly (GO:0097105)4.13608557
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.11191443
29neuron-neuron synaptic transmission (GO:0007270)4.10012663
30regulation of synaptic vesicle transport (GO:1902803)4.09053082
31exploration behavior (GO:0035640)4.07248703
32layer formation in cerebral cortex (GO:0021819)4.00231482
33regulation of neuronal synaptic plasticity (GO:0048168)3.96508377
34neuron recognition (GO:0008038)3.94002154
35neuronal ion channel clustering (GO:0045161)3.89954845
36gamma-aminobutyric acid transport (GO:0015812)3.88777728
37pyrimidine nucleobase catabolic process (GO:0006208)3.86143199
38negative regulation of synaptic transmission, GABAergic (GO:0032229)3.84665030
39presynaptic membrane organization (GO:0097090)3.80711267
40dendritic spine morphogenesis (GO:0060997)3.80296777
41membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.79605904
42regulation of synapse structural plasticity (GO:0051823)3.79078856
43regulation of excitatory postsynaptic membrane potential (GO:0060079)3.73806717
44regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.69436398
45amino acid import (GO:0043090)3.67622358
46positive regulation of synapse maturation (GO:0090129)3.66560440
47long-term synaptic potentiation (GO:0060291)3.65391302
48potassium ion homeostasis (GO:0055075)3.65145456
49transmission of nerve impulse (GO:0019226)3.63015021
50positive regulation of membrane potential (GO:0045838)3.62770512
51potassium ion import (GO:0010107)3.62606354
52regulation of postsynaptic membrane potential (GO:0060078)3.58626799
53gamma-aminobutyric acid signaling pathway (GO:0007214)3.58314957
54regulation of synaptic transmission, glutamatergic (GO:0051966)3.57862286
55long-term memory (GO:0007616)3.56613005
56proline transport (GO:0015824)3.56289176
57establishment of mitochondrion localization (GO:0051654)3.56143498
58positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.54600369
59cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54434763
60axonal fasciculation (GO:0007413)3.52981479
61auditory behavior (GO:0031223)3.45443282
62neurotransmitter transport (GO:0006836)3.43753595
63G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.42706373
64regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.40409654
65* regulation of synaptic plasticity (GO:0048167)3.36867365
66regulation of dendritic spine morphogenesis (GO:0061001)3.35674295
67cerebellar granule cell differentiation (GO:0021707)3.35616975
68synaptic vesicle endocytosis (GO:0048488)3.35554629
69response to auditory stimulus (GO:0010996)3.31189561
70synapse assembly (GO:0007416)3.30254002
71positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.30108466
72positive regulation of synaptic transmission, GABAergic (GO:0032230)3.27624191
73startle response (GO:0001964)3.27298204
74regulation of neurotransmitter secretion (GO:0046928)3.26152238
75response to histamine (GO:0034776)3.22363014
76positive regulation of synapse assembly (GO:0051965)3.21918122
77neurotransmitter uptake (GO:0001504)3.21601313
78cell communication by electrical coupling (GO:0010644)3.21301631
79neuromuscular process controlling balance (GO:0050885)3.20684134
80nucleobase catabolic process (GO:0046113)3.19999176
81cellular potassium ion homeostasis (GO:0030007)3.19865807
82cellular sodium ion homeostasis (GO:0006883)3.19196512
83regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.19098736
84regulation of neurotransmitter levels (GO:0001505)3.18410541
85positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.17397441
86adult walking behavior (GO:0007628)3.15310805
87regulation of vesicle fusion (GO:0031338)3.15100120
88positive regulation of dendritic spine morphogenesis (GO:0061003)3.13057323
89mechanosensory behavior (GO:0007638)3.12406122
90innervation (GO:0060384)3.12041879
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.10627034
92membrane depolarization during action potential (GO:0086010)3.10599466
93* learning (GO:0007612)3.08290881
94neuromuscular synaptic transmission (GO:0007274)3.08045003
95dendrite morphogenesis (GO:0048813)3.07955137
96behavioral defense response (GO:0002209)3.05733615
97behavioral fear response (GO:0001662)3.05733615
98membrane depolarization (GO:0051899)3.05585759
99regulation of neurotransmitter transport (GO:0051588)3.05577783
100central nervous system projection neuron axonogenesis (GO:0021952)3.02286694
101regulation of female receptivity (GO:0045924)3.01877108
102positive regulation of synaptic transmission (GO:0050806)3.00850257
103cerebellar Purkinje cell differentiation (GO:0021702)3.00537055
104cell migration in hindbrain (GO:0021535)2.99708176
105regulation of glutamate secretion (GO:0014048)2.99347449
106G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.98795709
107cerebral cortex radially oriented cell migration (GO:0021799)2.98635984
108regulation of synaptic transmission, GABAergic (GO:0032228)2.98511895
109regulation of synapse maturation (GO:0090128)2.98325918
110positive regulation of neurotransmitter transport (GO:0051590)2.97953686
111establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.97777607
112mitochondrion transport along microtubule (GO:0047497)2.97777607
113membrane hyperpolarization (GO:0060081)2.97662232
114prepulse inhibition (GO:0060134)2.97641641
115positive regulation of neurotransmitter secretion (GO:0001956)2.96731217
116regulation of respiratory system process (GO:0044065)2.96606779
117regulation of voltage-gated calcium channel activity (GO:1901385)2.96227503
118regulation of dendritic spine development (GO:0060998)2.94489397
119female mating behavior (GO:0060180)2.93744799
120synaptic transmission (GO:0007268)2.92933806
121synapse organization (GO:0050808)2.92066391
122fear response (GO:0042596)2.91792448
123* regulation of synaptic transmission (GO:0050804)2.91645018
124positive regulation of dendritic spine development (GO:0060999)2.90686511
125acidic amino acid transport (GO:0015800)2.90510024
126striatum development (GO:0021756)2.90327203
127intraspecies interaction between organisms (GO:0051703)2.90202819
128social behavior (GO:0035176)2.90202819

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.05187218
2GBX2_23144817_ChIP-Seq_PC3_Human4.07386357
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.11228430
4* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.01350786
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.95746164
6* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.59230458
7* REST_21632747_ChIP-Seq_MESCs_Mouse2.59190251
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.59009827
9* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.57297417
10* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.57297417
11* EZH2_27304074_Chip-Seq_ESCs_Mouse2.57224573
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.55582981
13* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.47178589
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.36469596
15* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.36203440
16* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.35742415
17GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.21801851
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.15839794
19SUZ12_27294783_Chip-Seq_ESCs_Mouse2.15806882
20* RNF2_27304074_Chip-Seq_ESCs_Mouse2.15620765
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.12977936
22AR_21572438_ChIP-Seq_LNCaP_Human2.11218979
23* DROSHA_22980978_ChIP-Seq_HELA_Human2.11042975
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.09017670
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.07490707
26TAF15_26573619_Chip-Seq_HEK293_Human2.06832659
27* REST_18959480_ChIP-ChIP_MESCs_Mouse2.03030256
28CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.94322555
29* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92074731
30* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86383571
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.84462620
32ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83323766
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82223076
34* SMAD4_21799915_ChIP-Seq_A2780_Human1.74599777
35P300_19829295_ChIP-Seq_ESCs_Human1.68095586
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.67613202
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.66824758
38PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66349996
39CBX2_27304074_Chip-Seq_ESCs_Mouse1.61976858
40MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.52082473
41PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.50881933
42BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47337482
43SMAD3_21741376_ChIP-Seq_EPCs_Human1.46401121
44PIAS1_25552417_ChIP-Seq_VCAP_Human1.45695203
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.43292824
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.43147749
47* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42059652
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.41795747
49* AR_25329375_ChIP-Seq_VCAP_Human1.38651218
50ERG_21242973_ChIP-ChIP_JURKAT_Human1.37700139
51OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.36310145
52RBPJ_22232070_ChIP-Seq_NCS_Mouse1.36106371
53ZNF274_21170338_ChIP-Seq_K562_Hela1.35544195
54IGF1R_20145208_ChIP-Seq_DFB_Human1.34960965
55* GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34758487
56SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.34488322
57* SOX2_21211035_ChIP-Seq_LN229_Gbm1.33887966
58RNF2_27304074_Chip-Seq_NSC_Mouse1.30747480
59FUS_26573619_Chip-Seq_HEK293_Human1.30590182
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.28352112
61NR3C1_23031785_ChIP-Seq_PC12_Mouse1.27257695
62* STAT3_23295773_ChIP-Seq_U87_Human1.26899786
63* RING1B_27294783_Chip-Seq_ESCs_Mouse1.25518604
64VDR_22108803_ChIP-Seq_LS180_Human1.25439795
65HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.23035951
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.22875683
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.22094005
68TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.20442418
69SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.17135595
70* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.16103640
71ARNT_22903824_ChIP-Seq_MCF-7_Human1.15428921
72* AR_19668381_ChIP-Seq_PC3_Human1.15142239
73AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.14734185
74UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.14231977
75* TCF4_23295773_ChIP-Seq_U87_Human1.13908057
76CDX2_19796622_ChIP-Seq_MESCs_Mouse1.12961352
77RING1B_27294783_Chip-Seq_NPCs_Mouse1.10085615
78P53_22127205_ChIP-Seq_FIBROBLAST_Human1.09958577
79AHR_22903824_ChIP-Seq_MCF-7_Human1.09855462
80* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09205080
81CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.09020582
82GATA1_26923725_Chip-Seq_HPCs_Mouse1.08596901
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.08552188
84* RUNX2_22187159_ChIP-Seq_PCA_Human1.08100227
85NR3C1_21868756_ChIP-Seq_MCF10A_Human1.07744497
86LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07451247
87ZFP281_18757296_ChIP-ChIP_E14_Mouse1.06805565
88ER_23166858_ChIP-Seq_MCF-7_Human1.05608038
89* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05574972
90KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.04933918
91TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.03677079
92JUN_21703547_ChIP-Seq_K562_Human1.03606107
93* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.03568727
94* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.03568727
95PRDM14_20953172_ChIP-Seq_ESCs_Human1.03367330
96STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02079412
97BCAT_22108803_ChIP-Seq_LS180_Human1.01866123
98* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.01763769
99TP53_20018659_ChIP-ChIP_R1E_Mouse1.01195601
100NANOG_18555785_Chip-Seq_ESCs_Mouse1.01096308
101TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00680397
102TP53_18474530_ChIP-ChIP_U2OS_Human1.00043113
103* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97899203
104* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97680782
105ZFP281_27345836_Chip-Seq_ESCs_Mouse0.97551980
106* CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.97168545
107SMAD3_21741376_ChIP-Seq_ESCs_Human0.96519571
108THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.96406124
109* SOX9_26525672_Chip-Seq_HEART_Mouse0.92891179
110KDM2B_26808549_Chip-Seq_K562_Human0.91084125
111SMAD4_21741376_ChIP-Seq_HESCs_Human0.90638820
112E2F1_18555785_Chip-Seq_ESCs_Mouse0.88705814
113DNAJC2_21179169_ChIP-ChIP_NT2_Human0.88386731
114WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87912497
115* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87412914
116CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.86655315
117KDM2B_26808549_Chip-Seq_REH_Human0.86136496
118SMAD3_21741376_ChIP-Seq_HESCs_Human0.86007122
119EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.85435018

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.65478545
2MP0003880_abnormal_central_pattern4.82655468
3* MP0003635_abnormal_synaptic_transmissio3.97001963
4MP0004270_analgesia3.64478804
5MP0009745_abnormal_behavioral_response3.37937277
6* MP0002063_abnormal_learning/memory/cond3.27192606
7MP0002064_seizures3.09807132
8MP0009046_muscle_twitch3.03993567
9MP0001968_abnormal_touch/_nociception3.00501978
10MP0002572_abnormal_emotion/affect_behav2.89461286
11MP0005423_abnormal_somatic_nervous2.80200881
12MP0002734_abnormal_mechanical_nocicepti2.70189625
13MP0002822_catalepsy2.66884878
14MP0001486_abnormal_startle_reflex2.59462102
15MP0002272_abnormal_nervous_system2.49539752
16MP0002736_abnormal_nociception_after2.46079535
17MP0002735_abnormal_chemical_nociception2.40343592
18MP0001440_abnormal_grooming_behavior2.26013063
19MP0001501_abnormal_sleep_pattern2.20762636
20MP0000778_abnormal_nervous_system2.16362502
21MP0002733_abnormal_thermal_nociception2.07145686
22MP0002067_abnormal_sensory_capabilities2.04696801
23MP0009780_abnormal_chondrocyte_physiolo2.03001474
24MP0006276_abnormal_autonomic_nervous1.98634870
25MP0001984_abnormal_olfaction1.95688804
26MP0001970_abnormal_pain_threshold1.95593188
27MP0005646_abnormal_pituitary_gland1.91624471
28MP0002184_abnormal_innervation1.88947700
29MP0002557_abnormal_social/conspecific_i1.88332739
30MP0004858_abnormal_nervous_system1.81673048
31MP0005386_behavior/neurological_phenoty1.77874148
32MP0004924_abnormal_behavior1.77874148
33MP0001529_abnormal_vocalization1.75690949
34MP0008569_lethality_at_weaning1.75028204
35MP0005645_abnormal_hypothalamus_physiol1.69385119
36MP0004811_abnormal_neuron_physiology1.62372033
37MP0003329_amyloid_beta_deposits1.55728233
38MP0001905_abnormal_dopamine_level1.54382072
39MP0003787_abnormal_imprinting1.53386919
40MP0002909_abnormal_adrenal_gland1.51966849
41MP0000955_abnormal_spinal_cord1.51011058
42MP0004885_abnormal_endolymph1.49484651
43MP0003879_abnormal_hair_cell1.45690614
44MP0002882_abnormal_neuron_morphology1.44301855
45MP0001188_hyperpigmentation1.42216805
46MP0001502_abnormal_circadian_rhythm1.40302088
47* MP0002066_abnormal_motor_capabilities/c1.39014514
48MP0003123_paternal_imprinting1.34354039
49MP0003122_maternal_imprinting1.33012297
50MP0004142_abnormal_muscle_tone1.31048845
51MP0000566_synostosis1.27127228
52MP0003121_genomic_imprinting1.19199933
53MP0003633_abnormal_nervous_system1.17821890
54MP0002152_abnormal_brain_morphology1.17384701
55MP0004742_abnormal_vestibular_system1.13671951
56MP0005499_abnormal_olfactory_system1.12406693
57MP0005394_taste/olfaction_phenotype1.12406693
58MP0003283_abnormal_digestive_organ1.04329585
59MP0003631_nervous_system_phenotype1.03822892
60MP0000631_abnormal_neuroendocrine_gland1.03234855
61MP0005551_abnormal_eye_electrophysiolog1.01854467
62MP0001963_abnormal_hearing_physiology0.99326118
63MP0010386_abnormal_urinary_bladder0.98288537
64MP0002876_abnormal_thyroid_physiology0.96394702
65MP0002069_abnormal_eating/drinking_beha0.93250347
66MP0003634_abnormal_glial_cell0.93061818
67MP0002229_neurodegeneration0.92475264
68MP0008872_abnormal_physiological_respon0.91462259
69MP0002638_abnormal_pupillary_reflex0.91133890
70MP0005409_darkened_coat_color0.88265255
71MP0001485_abnormal_pinna_reflex0.87207777
72MP0002752_abnormal_somatic_nervous0.86529559
73MP0002837_dystrophic_cardiac_calcinosis0.82694763
74MP0004085_abnormal_heartbeat0.82526741
75MP0001177_atelectasis0.80513603
76MP0003690_abnormal_glial_cell0.80455541
77MP0004133_heterotaxia0.78356400
78MP0000751_myopathy0.77910655
79MP0000579_abnormal_nail_morphology0.77862882
80MP0003632_abnormal_nervous_system0.77650100
81MP0004145_abnormal_muscle_electrophysio0.77330401
82MP0006292_abnormal_olfactory_placode0.75972423
83MP0000026_abnormal_inner_ear0.75905727
84MP0005171_absent_coat_pigmentation0.74700422
85MP0005535_abnormal_body_temperature0.73835167
86MP0008877_abnormal_DNA_methylation0.70880933
87MP0005253_abnormal_eye_physiology0.70467687
88MP0001299_abnormal_eye_distance/0.70203691
89MP0008874_decreased_physiological_sensi0.69580829
90MP0000013_abnormal_adipose_tissue0.67894497
91MP0003183_abnormal_peptide_metabolism0.65728318
92MP0003861_abnormal_nervous_system0.65386063
93MP0003137_abnormal_impulse_conducting0.65112827
94MP0001664_abnormal_digestion0.64986068
95MP0001986_abnormal_taste_sensitivity0.64917834
96MP0004215_abnormal_myocardial_fiber0.64562491
97MP0008789_abnormal_olfactory_epithelium0.64394108
98MP0005187_abnormal_penis_morphology0.64157819
99MP0009379_abnormal_foot_pigmentation0.63802953
100MP0010769_abnormal_survival0.62945782
101MP0000569_abnormal_digit_pigmentation0.62865888
102MP0002090_abnormal_vision0.62436103
103MP0001943_abnormal_respiration0.61044779
104MP0006072_abnormal_retinal_apoptosis0.60919720
105MP0003136_yellow_coat_color0.60135074
106MP0002249_abnormal_larynx_morphology0.59652147
107MP0005195_abnormal_posterior_eye0.59360694
108MP0010768_mortality/aging0.59066068
109MP0005167_abnormal_blood-brain_barrier0.58167055
110MP0000534_abnormal_ureter_morphology0.58087688
111MP0004484_altered_response_of0.56638993
112MP0000604_amyloidosis0.56629815
113MP0000920_abnormal_myelination0.56433543
114MP0003119_abnormal_digestive_system0.54926927
115MP0002653_abnormal_ependyma_morphology0.53989674
116MP0003938_abnormal_ear_development0.53148945
117MP0002082_postnatal_lethality0.52755706
118MP0010770_preweaning_lethality0.52755706

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.62469192
2Myokymia (HP:0002411)5.80241128
3Focal seizures (HP:0007359)5.43321660
4Epileptic encephalopathy (HP:0200134)5.11652101
5Atonic seizures (HP:0010819)4.73414120
6Visual hallucinations (HP:0002367)4.62609115
7Hyperventilation (HP:0002883)4.54269281
8Febrile seizures (HP:0002373)4.48658112
9Progressive cerebellar ataxia (HP:0002073)4.37511033
10Absence seizures (HP:0002121)4.03390703
11Broad-based gait (HP:0002136)3.75747114
12Dialeptic seizures (HP:0011146)3.72885289
13Generalized tonic-clonic seizures (HP:0002069)3.70913998
14Action tremor (HP:0002345)3.08474598
15Amblyopia (HP:0000646)3.05247150
16Supranuclear gaze palsy (HP:0000605)3.04915674
17Gaze-evoked nystagmus (HP:0000640)3.03230487
18Abnormality of binocular vision (HP:0011514)2.97933928
19Diplopia (HP:0000651)2.97933928
20Drooling (HP:0002307)2.96034989
21Excessive salivation (HP:0003781)2.96034989
22Abnormal eating behavior (HP:0100738)2.95588892
23Dysdiadochokinesis (HP:0002075)2.95324211
24Truncal ataxia (HP:0002078)2.95063314
25Impaired vibration sensation in the lower limbs (HP:0002166)2.93320894
26Poor eye contact (HP:0000817)2.86296972
27Anxiety (HP:0000739)2.77804898
28Epileptiform EEG discharges (HP:0011182)2.76996170
29Limb dystonia (HP:0002451)2.75441807
30Polyphagia (HP:0002591)2.71267713
31Hemiparesis (HP:0001269)2.70091380
32Gait imbalance (HP:0002141)2.68476956
33Progressive inability to walk (HP:0002505)2.67764627
34Depression (HP:0000716)2.66201149
35Genetic anticipation (HP:0003743)2.64711525
36Ankle clonus (HP:0011448)2.63360161
37EEG with generalized epileptiform discharges (HP:0011198)2.63218224
38Impaired social interactions (HP:0000735)2.63178769
39Abnormal social behavior (HP:0012433)2.63178769
40Pheochromocytoma (HP:0002666)2.62234390
41Dysmetria (HP:0001310)2.60796142
42Urinary bladder sphincter dysfunction (HP:0002839)2.57491877
43Megalencephaly (HP:0001355)2.56034238
44Mutism (HP:0002300)2.54855807
45Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.50203178
46Degeneration of the lateral corticospinal tracts (HP:0002314)2.50203178
47Hypsarrhythmia (HP:0002521)2.49918997
48Peripheral hypomyelination (HP:0007182)2.49628669
49Cerebral inclusion bodies (HP:0100314)2.49311044
50Neurofibrillary tangles (HP:0002185)2.46079578
51Fetal akinesia sequence (HP:0001989)2.44009465
52Split foot (HP:0001839)2.42524705
53Absent speech (HP:0001344)2.39043864
54Inability to walk (HP:0002540)2.31377851
55Neuroendocrine neoplasm (HP:0100634)2.29824123
56Stereotypic behavior (HP:0000733)2.26008239
57Postural instability (HP:0002172)2.25980490
58Morphological abnormality of the pyramidal tract (HP:0002062)2.24713554
59Congenital primary aphakia (HP:0007707)2.23605300
60Medial flaring of the eyebrow (HP:0010747)2.20942021
61Aplasia involving bones of the extremities (HP:0009825)2.20928709
62Aplasia involving bones of the upper limbs (HP:0009823)2.20928709
63Aplasia of the phalanges of the hand (HP:0009802)2.20928709
64Blue irides (HP:0000635)2.20460728
65Hepatoblastoma (HP:0002884)2.20089311
66Abnormal hair whorl (HP:0010721)2.17711440
67Abnormality of the corticospinal tract (HP:0002492)2.17152394
68Urinary urgency (HP:0000012)2.16564874
69Impaired smooth pursuit (HP:0007772)2.16237493
70Insidious onset (HP:0003587)2.15337961
71Termporal pattern (HP:0011008)2.15337961
72Specific learning disability (HP:0001328)2.15210590
73Scanning speech (HP:0002168)2.13762731
74Bradykinesia (HP:0002067)2.13271365
75Protruding tongue (HP:0010808)2.10005947
76Nephrogenic diabetes insipidus (HP:0009806)2.09370034
77Agitation (HP:0000713)2.09308617
78Spastic gait (HP:0002064)2.09176621
79Abnormality of salivation (HP:0100755)2.08585881
80Generalized myoclonic seizures (HP:0002123)2.05941572
81Torticollis (HP:0000473)2.04026425
82Impaired vibratory sensation (HP:0002495)2.01025049
83Hemiplegia (HP:0002301)2.00710629
84Status epilepticus (HP:0002133)2.00124161
85Focal dystonia (HP:0004373)1.99921292
86Narrow nasal bridge (HP:0000446)1.99736217
87Sleep apnea (HP:0010535)1.95620084
88Craniofacial dystonia (HP:0012179)1.93586566
89Failure to thrive in infancy (HP:0001531)1.92844963
90Lower limb muscle weakness (HP:0007340)1.92642833
91Akinesia (HP:0002304)1.91954444
92Spastic tetraplegia (HP:0002510)1.91932497
93Abnormality of the lower motor neuron (HP:0002366)1.91834872
94Papilledema (HP:0001085)1.91256976
95Genital tract atresia (HP:0001827)1.89377709
96Abnormality of ocular smooth pursuit (HP:0000617)1.88841025
97Oligodactyly (hands) (HP:0001180)1.88391228
98Insomnia (HP:0100785)1.87872332
99Vaginal atresia (HP:0000148)1.87772377
100Increased circulating renin level (HP:0000848)1.87589650
101Abnormality of the diencephalon (HP:0010662)1.87436492
102Bronchomalacia (HP:0002780)1.86010134
103Hypoplasia of the corpus callosum (HP:0002079)1.84937330
104Annular pancreas (HP:0001734)1.83602008
105Spastic tetraparesis (HP:0001285)1.83568988
106Hyperthyroidism (HP:0000836)1.83391462
107Amyotrophic lateral sclerosis (HP:0007354)1.82701537
108Dysmetric saccades (HP:0000641)1.82174503
109Cerebral hypomyelination (HP:0006808)1.82105959
110Gait ataxia (HP:0002066)1.81282738
111Turricephaly (HP:0000262)1.80433064
112Incomplete penetrance (HP:0003829)1.80072627
113Thickened helices (HP:0000391)1.79990297
114Intention tremor (HP:0002080)1.78870505
115Obstructive sleep apnea (HP:0002870)1.78773685
116Psychosis (HP:0000709)1.78591902
117Clonus (HP:0002169)1.76855295
118Hypoventilation (HP:0002791)1.73711557
119Cutaneous finger syndactyly (HP:0010554)1.72042575
120Abnormality of the labia minora (HP:0012880)1.71410541
121Poor suck (HP:0002033)1.71079584
122Tetraplegia (HP:0002445)1.68569787
123Ulnar claw (HP:0001178)1.67481607
124Alacrima (HP:0000522)1.64882842
125Optic nerve hypoplasia (HP:0000609)1.62823730
126Apathy (HP:0000741)1.61833453
127Morphological abnormality of the inner ear (HP:0011390)1.60749534

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.03125299
2EPHA43.96575113
3CASK3.80786820
4MARK13.50380254
5MAP3K43.18627910
6MAP2K73.03750915
7MAP3K92.99803885
8MINK12.62788981
9NTRK22.33752133
10MAP3K122.22653505
11DAPK22.09494665
12PLK21.90780589
13MAPK131.83584143
14MAP2K41.83271931
15PAK61.79276796
16PRPF4B1.78551850
17PNCK1.77393393
18TNIK1.77284260
19KSR11.69347180
20RIPK41.66640366
21PRKD31.60996740
22SIK31.50169984
23NTRK11.50038840
24DAPK11.49802638
25SIK21.48315613
26GRK51.45750396
27* CDK51.40330137
28PRKCG1.29943998
29CDK191.26811452
30SGK21.24344837
31KSR21.22307529
32CAMKK11.21561619
33PHKG11.21043836
34PHKG21.21043836
35SGK4941.20775135
36SGK2231.20775135
37ARAF1.09596649
38UHMK11.08776296
39CAMK2A1.07640389
40BMPR21.06193426
41FGFR21.02768000
42AKT30.98865990
43FES0.98410127
44CDK180.92288236
45DYRK1A0.90577046
46BCR0.89882977
47CAMKK20.88786274
48CAMK2B0.86907461
49CDK150.83553840
50SGK30.83213226
51CDK140.82890509
52OXSR10.81464383
53EPHB20.80915562
54PAK30.77584945
55PRKCE0.76357769
56NME10.75252386
57TYRO30.73859325
58FGR0.73401675
59SGK10.73354110
60MAP3K20.72306231
61CDK11A0.71969346
62STK380.70136191
63PTK2B0.69068472
64WNK30.68079534
65LATS20.67313966
66STK110.65996007
67CSNK1G20.65453768
68CAMK10.64312709
69PRKCH0.62654487
70LMTK20.61927406
71ALK0.57016581
72CCNB10.56624545
73RIPK10.56599530
74ERBB20.56166163
75MAP3K130.55483829
76RAF10.54461079
77ERBB30.51535934
78CAMK40.51484200
79MAPKAPK50.49743312
80MARK20.49726815
81ROCK10.49662184
82PRKCZ0.49131100
83STK390.47722612
84CAMK2D0.47455345
85DYRK20.46911944
86RET0.46175211
87FER0.45276317
88MUSK0.44780404
89MAPK150.44323253
90GRK70.43649260
91CAMK2G0.42774989
92MAP2K10.42736322
93CAMK1G0.42710341
94ROCK20.42487503
95ADRBK20.41955167
96NEK60.41843994
97PINK10.41717149
98PKN10.41417618
99MAPK120.41370850
100ADRBK10.40895087
101PRKG10.40832743
102CAMK1D0.40430909
103* RPS6KA30.40025960
104RPS6KA20.39742315
105BRAF0.39547039
106CSNK1G30.38349072
107CDC42BPA0.36957799
108TNK20.36777757
109FYN0.36665396
110CSNK1E0.35749187
111CSNK1D0.35480918
112WNK40.35177936
113CSNK1A1L0.35059040
114PRKACA0.34729014
115WNK10.34707765
116MAP3K60.34278866
117MAPK100.34101075
118CDK30.33798671
119BRSK10.33231634
120MAP4K20.32349119
121DMPK0.31415099
122CSNK1G10.30721998
123LIMK10.30592334
124CSNK1A10.28440225
125PRKDC0.27076043
126RPS6KB10.26559966
127DYRK1B0.26124433
128* GSK3B0.26085553

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.05574494
2Synaptic vesicle cycle_Homo sapiens_hsa047213.38019246
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.81809703
4GABAergic synapse_Homo sapiens_hsa047272.78953331
5Circadian entrainment_Homo sapiens_hsa047132.64750520
6Olfactory transduction_Homo sapiens_hsa047402.63456892
7Glutamatergic synapse_Homo sapiens_hsa047242.62050800
8Long-term potentiation_Homo sapiens_hsa047202.57811008
9Morphine addiction_Homo sapiens_hsa050322.55887027
10Amphetamine addiction_Homo sapiens_hsa050312.53464588
11Dopaminergic synapse_Homo sapiens_hsa047282.19919651
12Salivary secretion_Homo sapiens_hsa049702.09354253
13Collecting duct acid secretion_Homo sapiens_hsa049662.06091002
14Taste transduction_Homo sapiens_hsa047422.02572270
15Insulin secretion_Homo sapiens_hsa049111.99743252
16Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.94362629
17Serotonergic synapse_Homo sapiens_hsa047261.89105195
18Gastric acid secretion_Homo sapiens_hsa049711.82560089
19Cholinergic synapse_Homo sapiens_hsa047251.81128151
20Cocaine addiction_Homo sapiens_hsa050301.80550125
21Long-term depression_Homo sapiens_hsa047301.74697231
22Renin secretion_Homo sapiens_hsa049241.71421811
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.62726525
24Calcium signaling pathway_Homo sapiens_hsa040201.59964486
25Oxytocin signaling pathway_Homo sapiens_hsa049211.50440937
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.49864846
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.47268760
28Gap junction_Homo sapiens_hsa045401.34722652
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.33733354
30GnRH signaling pathway_Homo sapiens_hsa049121.28227090
31Vibrio cholerae infection_Homo sapiens_hsa051101.25943196
32Axon guidance_Homo sapiens_hsa043601.25700007
33Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22023651
34cAMP signaling pathway_Homo sapiens_hsa040241.20518540
35Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17496854
36Cardiac muscle contraction_Homo sapiens_hsa042601.10603097
37Vitamin B6 metabolism_Homo sapiens_hsa007501.10430916
38Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.09095602
39Phototransduction_Homo sapiens_hsa047441.05009856
40Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.04722353
41Melanogenesis_Homo sapiens_hsa049161.04447235
42Estrogen signaling pathway_Homo sapiens_hsa049151.02956622
43ErbB signaling pathway_Homo sapiens_hsa040121.02543342
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01719647
45Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01627506
46Glioma_Homo sapiens_hsa052140.97452682
47Bile secretion_Homo sapiens_hsa049760.97227871
48Oxidative phosphorylation_Homo sapiens_hsa001900.97203390
49Type II diabetes mellitus_Homo sapiens_hsa049300.95288890
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.93735760
51Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.91152711
52Alzheimers disease_Homo sapiens_hsa050100.87560197
53Vascular smooth muscle contraction_Homo sapiens_hsa042700.82040765
54Dorso-ventral axis formation_Homo sapiens_hsa043200.78413595
55Pancreatic secretion_Homo sapiens_hsa049720.73689726
56Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70926602
57Oocyte meiosis_Homo sapiens_hsa041140.69378334
58MAPK signaling pathway_Homo sapiens_hsa040100.68760771
59Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67212929
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.67090173
61Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.66802451
62Hippo signaling pathway_Homo sapiens_hsa043900.66029005
63Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.65940530
64Thyroid hormone synthesis_Homo sapiens_hsa049180.65816563
65Parkinsons disease_Homo sapiens_hsa050120.65504900
66Dilated cardiomyopathy_Homo sapiens_hsa054140.63296358
67Hedgehog signaling pathway_Homo sapiens_hsa043400.62081817
68Choline metabolism in cancer_Homo sapiens_hsa052310.61454714
69Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60955535
70Type I diabetes mellitus_Homo sapiens_hsa049400.60117371
71Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.59508338
72Ras signaling pathway_Homo sapiens_hsa040140.58920354
73Nitrogen metabolism_Homo sapiens_hsa009100.56634025
74Alcoholism_Homo sapiens_hsa050340.55455794
75Circadian rhythm_Homo sapiens_hsa047100.53483819
76Glucagon signaling pathway_Homo sapiens_hsa049220.53456155
77Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53226202
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52091523
79Rap1 signaling pathway_Homo sapiens_hsa040150.50450639
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48540680
81Wnt signaling pathway_Homo sapiens_hsa043100.48392617
82Basal cell carcinoma_Homo sapiens_hsa052170.47727125
83Tight junction_Homo sapiens_hsa045300.47598085
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.47407100
85Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.47350239
86Huntingtons disease_Homo sapiens_hsa050160.46277309
87Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44330965
88Sphingolipid signaling pathway_Homo sapiens_hsa040710.44082658
89Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43575064
90Rheumatoid arthritis_Homo sapiens_hsa053230.42955520
91African trypanosomiasis_Homo sapiens_hsa051430.42464086
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42313158
93Inositol phosphate metabolism_Homo sapiens_hsa005620.41371934
94Histidine metabolism_Homo sapiens_hsa003400.40956179
95Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.39950019
96beta-Alanine metabolism_Homo sapiens_hsa004100.38923402
97Endometrial cancer_Homo sapiens_hsa052130.38528277
98SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38010250
99VEGF signaling pathway_Homo sapiens_hsa043700.37360994
100Renal cell carcinoma_Homo sapiens_hsa052110.35726485
101Ovarian steroidogenesis_Homo sapiens_hsa049130.34556715
102Prion diseases_Homo sapiens_hsa050200.32457969
103Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.30803291
104Butanoate metabolism_Homo sapiens_hsa006500.30585703
105Phagosome_Homo sapiens_hsa041450.29569560
106Endocytosis_Homo sapiens_hsa041440.29537776
107Insulin signaling pathway_Homo sapiens_hsa049100.29450842
108Melanoma_Homo sapiens_hsa052180.29298982
109Fatty acid biosynthesis_Homo sapiens_hsa000610.28747873
110Colorectal cancer_Homo sapiens_hsa052100.27741067
111Notch signaling pathway_Homo sapiens_hsa043300.27401280
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.26776074
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.26631604
114Longevity regulating pathway - mammal_Homo sapiens_hsa042110.25336603

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »