CTNS

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a seven-transmembrane domain protein that functions to transport cystine out of lysosomes. Its activity is driven by the H+ electrochemical gradient of the lysosomal membrane. Mutations in this gene cause cystinosis, a lysosomal storage disorder. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1fusion of sperm to egg plasma membrane (GO:0007342)5.28374919
2regulation of cholesterol esterification (GO:0010872)5.12915069
3mitochondrial calcium ion transport (GO:0006851)4.60946065
4modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.32165651
5positive regulation by organism of defense response of other organism involved in symbiotic interact4.32165651
6modulation by symbiont of host immune response (GO:0052553)4.32165651
7positive regulation by symbiont of host defense response (GO:0052509)4.32165651
8modulation by symbiont of host defense response (GO:0052031)4.32165651
9modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.32165651
10glycosphingolipid catabolic process (GO:0046479)4.31883717
11adenosine receptor signaling pathway (GO:0001973)4.15453155
12response to peptidoglycan (GO:0032494)4.12804893
13amino sugar catabolic process (GO:0046348)3.95192942
14NIK/NF-kappaB signaling (GO:0038061)3.93399421
15glycolipid catabolic process (GO:0019377)3.89190800
16regulation of T-helper 2 cell differentiation (GO:0045628)3.87275956
17regulation of interferon-beta biosynthetic process (GO:0045357)3.86886589
18plasma membrane fusion (GO:0045026)3.83491165
19production of molecular mediator involved in inflammatory response (GO:0002532)3.75392238
20neutrophil activation involved in immune response (GO:0002283)3.71922547
21sperm motility (GO:0030317)3.71044433
22macrophage activation involved in immune response (GO:0002281)3.69490202
23positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.69363088
24negative regulation of cell size (GO:0045792)3.58219854
25regulation of mast cell degranulation (GO:0043304)3.57834154
26acrosome reaction (GO:0007340)3.52618831
27positive regulation of mast cell activation involved in immune response (GO:0033008)3.49280144
28positive regulation of mast cell degranulation (GO:0043306)3.49280144
29mannose metabolic process (GO:0006013)3.46973651
30hyaluronan catabolic process (GO:0030214)3.46552779
31regulation of mast cell activation involved in immune response (GO:0033006)3.44426588
32cellular response to thyroid hormone stimulus (GO:0097067)3.43671432
33barbed-end actin filament capping (GO:0051016)3.40004304
34ceramide catabolic process (GO:0046514)3.36930026
35sulfur amino acid catabolic process (GO:0000098)3.34434764
36positive regulation of chemokine biosynthetic process (GO:0045080)3.33047669
37cellular response to arsenic-containing substance (GO:0071243)3.32492124
38pinocytosis (GO:0006907)3.28821780
39lipoxygenase pathway (GO:0019372)3.25337399
40response to host immune response (GO:0052572)3.19384357
41response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.19384357
42oligosaccharide catabolic process (GO:0009313)3.18300947
43regulation of leukocyte degranulation (GO:0043300)3.16185582
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.15278753
45sperm capacitation (GO:0048240)3.14855292
46positive regulation of cellular amide metabolic process (GO:0034250)3.14746300
47Golgi transport vesicle coating (GO:0048200)3.14190883
48COPI coating of Golgi vesicle (GO:0048205)3.14190883
49microglial cell activation (GO:0001774)3.13813621
50I-kappaB phosphorylation (GO:0007252)3.13430813
51regulation of early endosome to late endosome transport (GO:2000641)3.12078152
52positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.08355364
53negative regulation of digestive system process (GO:0060457)3.08123120
54response to acidic pH (GO:0010447)3.05921561
55alpha-linolenic acid metabolic process (GO:0036109)3.05303216
56maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.04001061
57membrane protein intracellular domain proteolysis (GO:0031293)3.03941413
58regulation of myeloid leukocyte mediated immunity (GO:0002886)3.02110981
59negative regulation of interleukin-12 production (GO:0032695)3.01606430
60peptide catabolic process (GO:0043171)3.01142558
61response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.00752672
62response to host (GO:0075136)3.00752672
63response to host defenses (GO:0052200)3.00752672
64neutrophil mediated immunity (GO:0002446)3.00412716
65valine metabolic process (GO:0006573)3.00038098
66sequestering of metal ion (GO:0051238)2.99952733
67low-density lipoprotein particle clearance (GO:0034383)2.99166239
68triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.98050016
69protein carboxylation (GO:0018214)2.97130368
70peptidyl-glutamic acid carboxylation (GO:0017187)2.97130368
71positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.97075633
72membrane lipid catabolic process (GO:0046466)2.94752547
73erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.94040695
74L-phenylalanine catabolic process (GO:0006559)2.94040695
75polyamine biosynthetic process (GO:0006596)2.92924182
76sphingolipid catabolic process (GO:0030149)2.92653182
77protein localization to endosome (GO:0036010)2.92311377
78detection of molecule of bacterial origin (GO:0032490)2.91233851
79response to thyroid hormone (GO:0097066)2.90955187
80low-density lipoprotein particle remodeling (GO:0034374)2.87900635
81phosphatidylethanolamine biosynthetic process (GO:0006646)2.87866764
82cellular modified amino acid catabolic process (GO:0042219)2.85742636
83reverse cholesterol transport (GO:0043691)2.85207522
84keratan sulfate catabolic process (GO:0042340)2.82765301
85immunoglobulin mediated immune response (GO:0016064)2.82253304
86regulation of vitamin D biosynthetic process (GO:0060556)2.81984407
87regulation of cholesterol efflux (GO:0010874)2.81523413
88tooth mineralization (GO:0034505)2.81374206
89regulation of mast cell activation (GO:0033003)2.80452785
90protein retention in ER lumen (GO:0006621)2.80248003
91multicellular organism reproduction (GO:0032504)2.76929661
92plasma lipoprotein particle clearance (GO:0034381)2.76473813
93regulation of chemokine biosynthetic process (GO:0045073)2.75705834
94cellular extravasation (GO:0045123)2.73932778
95killing of cells in other organism involved in symbiotic interaction (GO:0051883)2.73257088
96disruption of cells of other organism involved in symbiotic interaction (GO:0051818)2.73257088
97cellular response to ATP (GO:0071318)2.73234714
98positive regulation of monocyte chemotaxis (GO:0090026)2.72954663
99high-density lipoprotein particle remodeling (GO:0034375)2.72905690
100regulation of cholesterol storage (GO:0010885)2.72326399
101fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.72018462
102prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.69206665
103positive regulation of receptor recycling (GO:0001921)2.68076937
104negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.67595750
105plasma lipoprotein particle organization (GO:0071827)2.67350653
106plasma lipoprotein particle assembly (GO:0034377)2.66666010
107apoptotic cell clearance (GO:0043277)2.66663254
108protein-lipid complex remodeling (GO:0034368)2.65101285
109macromolecular complex remodeling (GO:0034367)2.65101285
110plasma lipoprotein particle remodeling (GO:0034369)2.65101285
111macrophage activation (GO:0042116)2.64737702
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.64722823
113branching involved in prostate gland morphogenesis (GO:0060442)2.63521753
114positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.62329575
115protein-lipid complex subunit organization (GO:0071825)2.61162102
116phosphatidylethanolamine metabolic process (GO:0046337)2.61157656
117decidualization (GO:0046697)2.60295114
118membrane protein ectodomain proteolysis (GO:0006509)2.59785548
119cysteine metabolic process (GO:0006534)2.59537167
120chromosome condensation (GO:0030261)2.57704036
121myelin assembly (GO:0032288)2.56991384
122regulation of mononuclear cell migration (GO:0071675)2.56949287
123very-low-density lipoprotein particle assembly (GO:0034379)2.56866266
124exocrine pancreas development (GO:0031017)2.56277429
125erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.56103560
126L-phenylalanine metabolic process (GO:0006558)2.56103560
127protein-lipid complex assembly (GO:0065005)2.56084022
128transcytosis (GO:0045056)2.55902380
129aldehyde catabolic process (GO:0046185)2.53813720
130detection of other organism (GO:0098543)2.53708340
131detection of external biotic stimulus (GO:0098581)2.53137205
132reproduction (GO:0000003)2.52984546
133respiratory burst (GO:0045730)2.51360132
134phospholipid efflux (GO:0033700)2.51314749
135positive regulation of leukocyte degranulation (GO:0043302)2.50813096
136aromatic amino acid family catabolic process (GO:0009074)2.49585278
137virion attachment to host cell (GO:0019062)2.49234930
138adhesion of symbiont to host cell (GO:0044650)2.49234930
139positive regulation of calcium ion import (GO:0090280)2.48510211
140complement activation, alternative pathway (GO:0006957)2.48001141
141regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.47646375
142positive regulation of interferon-alpha production (GO:0032727)2.47273121
143regulation of heat generation (GO:0031650)2.47040875
144cholesterol efflux (GO:0033344)2.46740575
145positive regulation of B cell differentiation (GO:0045579)2.45725059
146negative regulation of tumor necrosis factor production (GO:0032720)2.44499474
147rRNA methylation (GO:0031167)2.43902949
148mitochondrial calcium ion homeostasis (GO:0051560)2.43217127
149stress fiber assembly (GO:0043149)2.42531101
150negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.42149836
151N-acetylneuraminate metabolic process (GO:0006054)2.41358473
152adhesion of symbiont to host (GO:0044406)2.41257284
153phospholipid homeostasis (GO:0055091)2.41158657
154leukocyte migration involved in inflammatory response (GO:0002523)2.41003104
155sexual reproduction (GO:0019953)2.40061985
156regulation of protein activation cascade (GO:2000257)2.39680112
157Arp2/3 complex-mediated actin nucleation (GO:0034314)2.39032778
158positive regulation of mast cell activation (GO:0033005)2.38553975
159DNA packaging (GO:0006323)2.38183497
160positive regulation of interleukin-6 production (GO:0032755)2.37943796
161negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)2.37280581
162activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.37239040
163single strand break repair (GO:0000012)2.36680489
164regulation of complement activation (GO:0030449)2.36235324
165negative regulation of necrotic cell death (GO:0060547)2.35842391
166amyloid precursor protein catabolic process (GO:0042987)2.34994617
167positive regulation of type 2 immune response (GO:0002830)2.34403184
168myeloid dendritic cell differentiation (GO:0043011)2.33758402
169granulocyte activation (GO:0036230)2.33639148
170regulation of podosome assembly (GO:0071801)2.32973668
171regulation of type 2 immune response (GO:0002828)2.32555016
172lysosome organization (GO:0007040)2.32496000
173lytic vacuole organization (GO:0080171)2.32496000
174myeloid leukocyte mediated immunity (GO:0002444)2.31579273
175tryptophan metabolic process (GO:0006568)2.31544929
176G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.31373565
177regulation of tumor necrosis factor superfamily cytokine production (GO:1903555)2.31293161
178negative regulation of mast cell activation (GO:0033004)2.30939189
179negative regulation of sterol transport (GO:0032372)2.29502133
180negative regulation of cholesterol transport (GO:0032375)2.29502133
181positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.29327808
182hormone catabolic process (GO:0042447)2.28558399

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human6.50942137
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.30146055
3RXR_22158963_ChIP-Seq_LIVER_Mouse3.67641029
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.59911040
5PPARA_22158963_ChIP-Seq_LIVER_Mouse3.52524289
6LXR_22158963_ChIP-Seq_LIVER_Mouse3.38178504
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.22741575
8IRF8_22096565_ChIP-ChIP_GC-B_Human2.98045506
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.80772266
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.79172640
11STAT6_21828071_ChIP-Seq_BEAS2B_Human2.79109413
12SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.53820703
13PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.51697456
14GATA1_22025678_ChIP-Seq_K562_Human2.51686994
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.50606848
16STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.45440194
17EGR1_23403033_ChIP-Seq_LIVER_Mouse2.42143283
18VDR_21846776_ChIP-Seq_THP-1_Human2.37253340
19NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.35570642
20NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29691875
21CLOCK_20551151_ChIP-Seq_293T_Human2.26707423
22NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.17137301
23ELK3_25401928_ChIP-Seq_HUVEC_Human2.13899475
24ELF1_20517297_ChIP-Seq_JURKAT_Human2.12208171
25ESR1_21235772_ChIP-Seq_MCF-7_Human2.10469242
26CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06834676
27VDR_24763502_ChIP-Seq_THP-1_Human2.04594098
28* P68_20966046_ChIP-Seq_HELA_Human2.00417905
29PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.99845893
30BCL6_27268052_Chip-Seq_Bcells_Human1.99553207
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.93829503
32BCOR_27268052_Chip-Seq_Bcells_Human1.93091555
33* RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84858904
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.80052927
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73462306
36ESR2_21235772_ChIP-Seq_MCF-7_Human1.67629353
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66305177
38RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.66121619
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.66058365
40MYB_21317192_ChIP-Seq_ERMYB_Mouse1.64926215
41GATA2_21666600_ChIP-Seq_HMVEC_Human1.63018914
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.62860339
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.61596231
44BRD4_27068464_Chip-Seq_AML-cells_Mouse1.58068635
45SMC4_20622854_ChIP-Seq_HELA_Human1.57475586
46PHF8_20622854_ChIP-Seq_HELA_Human1.57462466
47CTCF_27219007_Chip-Seq_ERYTHROID_Human1.56700916
48STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.56434318
49CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.54958565
50TET1_21451524_ChIP-Seq_MESCs_Mouse1.53798846
51RACK7_27058665_Chip-Seq_MCF-7_Human1.53671836
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.53526698
53TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53196407
54NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53012344
55NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53012344
56DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.50280610
57CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.49437813
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.48731260
59MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.48561804
60TCF7_22412390_ChIP-Seq_EML_Mouse1.44779621
61MAF_26560356_Chip-Seq_TH2_Human1.43296805
62SOX2_27498859_Chip-Seq_STOMACH_Mouse1.42932708
63* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.42148230
64* CTCF_20526341_ChIP-Seq_ESCs_Human1.41485114
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.40741350
66YY1_22570637_ChIP-Seq_MALME-3M_Human1.37805171
67SOX2_20726797_ChIP-Seq_SW620_Human1.36983676
68MAF_26560356_Chip-Seq_TH1_Human1.35642612
69PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35278800
70SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.34955768
71GATA1_22383799_ChIP-Seq_G1ME_Mouse1.34736385
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.34549018
73TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.34430430
74KDM2B_26808549_Chip-Seq_DND41_Human1.32796984
75* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.32767209
76TP63_22573176_ChIP-Seq_HFKS_Human1.31908131
77NCOR1_26117541_ChIP-Seq_K562_Human1.30232328
78CTCF_21964334_Chip-Seq_Bcells_Human1.29838023
79* E2F1_20622854_ChIP-Seq_HELA_Human1.28680328
80GATA4_25053715_ChIP-Seq_YYC3_Human1.26915940
81SPI1_23547873_ChIP-Seq_NB4_Human1.25830142
82TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24909235
83UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.24364979
84VDR_24787735_ChIP-Seq_THP-1_Human1.22491390
85KDM2B_26808549_Chip-Seq_K562_Human1.21508211
86TFEB_21752829_ChIP-Seq_HELA_Human1.21296266
87UTX_26944678_Chip-Seq_JUKART_Human1.20676607
88* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.20109345
89FOXA2_19822575_ChIP-Seq_HepG2_Human1.19528792
90SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19339351
91ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.19148601
92SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.18775248
93PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.18259842
94* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17724520
95IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.17507634
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17025381
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16766344
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.15890940
99GATA2_19941826_ChIP-Seq_K562_Human1.15683756
100PU_27001747_Chip-Seq_BMDM_Mouse1.15407567
101FOXO3_23340844_ChIP-Seq_DLD1_Human1.14992796
102GATA1_19941826_ChIP-Seq_K562_Human1.14479020
103PPAR_26484153_Chip-Seq_NCI-H1993_Human1.14366258
104SRY_22984422_ChIP-ChIP_TESTIS_Rat1.13361414
105SA1_27219007_Chip-Seq_Bcells_Human1.12344586
106RUNX_20019798_ChIP-Seq_JUKART_Human1.11932319
107SCL_19346495_ChIP-Seq_HPC-7_Human1.11787978
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.11494662
109VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.11306146
110SPI1_20517297_ChIP-Seq_HL60_Human1.10976548
111CTCF_27219007_Chip-Seq_Bcells_Human1.10621409
112TP53_22127205_ChIP-Seq_IMR90_Human1.10475233
113FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.10335610
114CTCF_21964334_ChIP-Seq_BJAB-B_Human1.10132398
115CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09717301
116P300_27268052_Chip-Seq_Bcells_Human1.09551038
117RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.09102509
118FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08611491
119CJUN_26792858_Chip-Seq_BT549_Human1.08074960
120EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.07965182
121CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07348432
122IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07204123
123FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.07169139
124ATF3_27146783_Chip-Seq_COLON_Human1.06728277
125* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.05697265
126TRIM28_21343339_ChIP-Seq_HEK293_Human1.05619332
127FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.04216728
128CTCF_26484167_Chip-Seq_Bcells_Mouse1.04212915
129AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04097712
130CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.03755142
131LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03484431
132SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02745269
133TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.02677743
134GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.01499239
135CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01445109
136PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00345938
137ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00253004
138MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98787930
139BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98632719
140TP63_17297297_ChIP-ChIP_HaCaT_Human0.98530032
141P63_26484246_Chip-Seq_KERATINOCYTES_Human0.98405314
142CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.96173273
143FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.95648324
144NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95320163
145VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.94591784
146TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.93998269
147STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.93980039
148LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93637392
149CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90924144
150GATA1_19941827_ChIP-Seq_MEL_Mouse0.88300670
151SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.88100852
152E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86394582
153FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84590351
154RUNX1_22412390_ChIP-Seq_EML_Mouse0.84373084
155LXR_22292898_ChIP-Seq_THP-1_Human0.83570532
156CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82332424
157SPI1_23127762_ChIP-Seq_K562_Human0.81178579
158TP63_23658742_ChIP-Seq_EP156T_Human0.78395014
159GATA3_26560356_Chip-Seq_TH2_Human0.77547871
160SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77177722
161* HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77112176

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005058_abnormal_lysosome_morphology4.63050033
2MP0005410_abnormal_fertilization3.98136949
3MP0002139_abnormal_hepatobiliary_system3.25219967
4MP0008438_abnormal_cutaneous_collagen3.13599172
5MP0005365_abnormal_bile_salt3.04205862
6MP0005360_urolithiasis3.04044906
7MP0009840_abnormal_foam_cell2.85465448
8MP0003300_gastrointestinal_ulcer2.59040475
9MP0003191_abnormal_cellular_cholesterol2.57618153
10MP0005451_abnormal_body_composition2.51497061
11MP0008004_abnormal_stomach_pH2.49063956
12MP0006082_CNS_inflammation2.44863561
13MP0000678_abnormal_parathyroid_gland2.44552040
14MP0003172_abnormal_lysosome_physiology2.41306187
15MP0003436_decreased_susceptibility_to2.31985163
16MP0004510_myositis2.21652206
17MP0003183_abnormal_peptide_metabolism2.19810727
18MP0005085_abnormal_gallbladder_physiolo2.19133941
19MP0010386_abnormal_urinary_bladder2.14347200
20MP0000013_abnormal_adipose_tissue2.05850571
21MP0003690_abnormal_glial_cell2.00231644
22MP0009764_decreased_sensitivity_to1.95347630
23MP0008260_abnormal_autophagy1.93358973
24MP0002419_abnormal_innate_immunity1.92725429
25MP0010329_abnormal_lipoprotein_level1.91163448
26MP0003705_abnormal_hypodermis_morpholog1.87063596
27* MP0005332_abnormal_amino_acid1.81892842
28MP0003806_abnormal_nucleotide_metabolis1.81770450
29MP0001666_abnormal_nutrient_absorption1.79318995
30MP0002877_abnormal_melanocyte_morpholog1.77593012
31MP0001533_abnormal_skeleton_physiology1.76008052
32MP0003329_amyloid_beta_deposits1.74415038
33MP0003252_abnormal_bile_duct1.69838867
34MP0005671_abnormal_response_to1.68369413
35MP0004019_abnormal_vitamin_homeostasis1.61561502
36MP0003724_increased_susceptibility_to1.58968525
37MP0008875_abnormal_xenobiotic_pharmacok1.58130354
38MP0001835_abnormal_antigen_presentation1.57862598
39MP0009333_abnormal_splenocyte_physiolog1.52024125
40MP0002254_reproductive_system_inflammat1.48163637
41MP0001958_emphysema1.46695489
42MP0003566_abnormal_cell_adhesion1.45872866
43MP0005464_abnormal_platelet_physiology1.45698240
44MP0005310_abnormal_salivary_gland1.44949990
45MP0003878_abnormal_ear_physiology1.40680561
46MP0005377_hearing/vestibular/ear_phenot1.40680561
47MP0001545_abnormal_hematopoietic_system1.40231213
48MP0005397_hematopoietic_system_phenotyp1.40231213
49MP0004947_skin_inflammation1.39622532
50MP0002148_abnormal_hypersensitivity_rea1.38774569
51MP0003656_abnormal_erythrocyte_physiolo1.36487641
52MP0004233_abnormal_muscle_weight1.35972334
53MP0002138_abnormal_hepatobiliary_system1.31442931
54MP0009643_abnormal_urine_homeostasis1.31273801
55MP0000015_abnormal_ear_pigmentation1.27245629
56MP0000604_amyloidosis1.25621172
57MP0002405_respiratory_system_inflammati1.24921100
58MP0000609_abnormal_liver_physiology1.24832183
59MP0010307_abnormal_tumor_latency1.24081941
60MP0005275_abnormal_skin_tensile1.23393224
61MP0002118_abnormal_lipid_homeostasis1.23034675
62MP0006054_spinal_hemorrhage1.22891507
63MP0001756_abnormal_urination1.22766972
64MP0009785_altered_susceptibility_to1.21200752
65MP0003091_abnormal_cell_migration1.20626298
66MP0005164_abnormal_response_to1.20171460
67MP0002998_abnormal_bone_remodeling1.19976844
68MP0001845_abnormal_inflammatory_respons1.18997012
69MP0000371_diluted_coat_color1.18496209
70MP0000343_altered_response_to1.17790945
71MP0004883_abnormal_blood_vessel1.16900486
72MP0003075_altered_response_to1.16111323
73MP0008469_abnormal_protein_level1.15333296
74MP0002132_abnormal_respiratory_system1.15145078
75MP0005390_skeleton_phenotype1.12490780
76MP0001849_ear_inflammation1.11081881
77MP0005025_abnormal_response_to1.08743963
78MP0000465_gastrointestinal_hemorrhage1.08609641
79MP0003453_abnormal_keratinocyte_physiol1.07985802
80MP0005166_decreased_susceptibility_to1.07472086
81MP0005023_abnormal_wound_healing1.07052201
82MP0005000_abnormal_immune_tolerance1.06592435
83MP0000858_altered_metastatic_potential1.05704419
84MP0005220_abnormal_exocrine_pancreas1.04448263
85MP0005319_abnormal_enzyme/_coenzyme1.03917719
86MP0004264_abnormal_extraembryonic_tissu1.03448763
87MP0002420_abnormal_adaptive_immunity1.01730004
88MP0001819_abnormal_immune_cell1.01611956
89MP0002452_abnormal_antigen_presenting1.01104157
90MP0005257_abnormal_intraocular_pressure1.00852836
91MP0002060_abnormal_skin_morphology1.00410392
92MP0003828_pulmonary_edema1.00351445
93MP0002136_abnormal_kidney_physiology1.00342183
94MP0000003_abnormal_adipose_tissue0.95663033
95MP0003279_aneurysm0.94698598
96MP0003186_abnormal_redox_activity0.93996307
97MP0005387_immune_system_phenotype0.93791172
98MP0001790_abnormal_immune_system0.93791172
99MP0003011_delayed_dark_adaptation0.93403406
100MP0002090_abnormal_vision0.91065323
101MP0005167_abnormal_blood-brain_barrier0.90930385
102MP0001243_abnormal_dermal_layer0.90429137
103MP0005083_abnormal_biliary_tract0.89832928
104MP0001800_abnormal_humoral_immune0.88172545
105MP0000538_abnormal_urinary_bladder0.86434459
106MP0005647_abnormal_sex_gland0.86049988
107MP0000598_abnormal_liver_morphology0.85797858
108MP0005503_abnormal_tendon_morphology0.84685588
109MP0000249_abnormal_blood_vessel0.83747081
110MP0009278_abnormal_bone_marrow0.83416809
111MP0005409_darkened_coat_color0.83029753
112MP0009763_increased_sensitivity_to0.81890163
113MP0004858_abnormal_nervous_system0.81672947
114MP0005670_abnormal_white_adipose0.80189878
115MP0005171_absent_coat_pigmentation0.79049527
116* MP0003795_abnormal_bone_structure0.79045702
117MP0000685_abnormal_immune_system0.78513151
118MP0002723_abnormal_immune_serum0.78508991
119MP0001853_heart_inflammation0.78303422
120MP0004043_abnormal_pH_regulation0.78210903
121MP0000767_abnormal_smooth_muscle0.77509905
122MP0002098_abnormal_vibrissa_morphology0.76895081
123MP0002653_abnormal_ependyma_morphology0.76544685
124MP0002938_white_spotting0.75963652
125MP0001324_abnormal_eye_pigmentation0.75466807
126MP0001764_abnormal_homeostasis0.75162766
127MP0009384_cardiac_valve_regurgitation0.75012507
128MP0003448_altered_tumor_morphology0.74859410
129MP0003303_peritoneal_inflammation0.73795929
130MP0003698_abnormal_male_reproductive0.73725184
131MP0000716_abnormal_immune_system0.72057478
132MP0005174_abnormal_tail_pigmentation0.71925727
133MP0002429_abnormal_blood_cell0.68974322
134MP0003950_abnormal_plasma_membrane0.68489561
135MP0004808_abnormal_hematopoietic_stem0.67063834
136MP0000920_abnormal_myelination0.66331943
137MP0009115_abnormal_fat_cell0.65310313
138MP0001348_abnormal_lacrimal_gland0.65115599
139MP0004381_abnormal_hair_follicle0.64935061
140MP0002398_abnormal_bone_marrow0.64335070
141MP0002127_abnormal_cardiovascular_syste0.64300858

Predicted human phenotypes

RankGene SetZ-score
1Vacuolated lymphocytes (HP:0001922)5.90668322
2Increased cerebral lipofuscin (HP:0011813)4.68318680
3Dysostosis multiplex (HP:0000943)4.62572284
4Increased neuronal autofluorescent lipopigment (HP:0002074)4.46936112
5Systemic lupus erythematosus (HP:0002725)4.20576837
6Urinary glycosaminoglycan excretion (HP:0003541)4.09031085
7Mucopolysacchariduria (HP:0008155)4.09031085
8Purpura (HP:0000979)3.96017045
9Abnormality of mucopolysaccharide metabolism (HP:0011020)3.95678865
10Abnormality of polysaccharide metabolism (HP:0011012)3.95678865
11Abnormality of glycosaminoglycan metabolism (HP:0004371)3.95678865
12Petechiae (HP:0000967)3.88430878
13Recurrent gram-negative bacterial infections (HP:0005420)3.74286696
14Loss of speech (HP:0002371)3.70902920
15Recurrent bacterial skin infections (HP:0005406)3.47690474
16Eczematoid dermatitis (HP:0000976)3.45470615
17Recurrent abscess formation (HP:0002722)3.38096515
18Prolonged neonatal jaundice (HP:0006579)3.37241957
19Glomerulonephritis (HP:0000099)3.21685591
20Abnormality of liposaccharide metabolism (HP:0010968)3.20578654
21Abnormality of glycosphingolipid metabolism (HP:0004343)3.20578654
22Abnormality of glycolipid metabolism (HP:0010969)3.20578654
23Abnormality of macrophages (HP:0004311)3.15952066
24Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.15024563
25Axonal loss (HP:0003447)3.08822664
26Nuclear cataract (HP:0100018)3.08441686
27Complement deficiency (HP:0004431)3.05231703
28Severe visual impairment (HP:0001141)3.03649771
29Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.97851056
30Xanthomatosis (HP:0000991)2.95676799
31Intrahepatic cholestasis (HP:0001406)2.90184524
32Epistaxis (HP:0000421)2.83651436
33Prolonged bleeding time (HP:0003010)2.83092913
34Increased serum ferritin (HP:0003281)2.81291875
35Thin bony cortex (HP:0002753)2.81209517
36Spontaneous hematomas (HP:0007420)2.70731137
37* Male infertility (HP:0003251)2.64817061
38Progressive visual loss (HP:0000529)2.64307581
39Abnormality of the nasal mucosa (HP:0000433)2.64025257
40Hydroxyprolinuria (HP:0003080)2.63858377
41Abnormality of proline metabolism (HP:0010907)2.63858377
42Deep venous thrombosis (HP:0002625)2.60885310
43Abnormality of the vasculature of the conjunctiva (HP:0008054)2.60413508
44Spondylolisthesis (HP:0003302)2.56489890
45Cervical subluxation (HP:0003308)2.54984087
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.52387426
47Vertebral compression fractures (HP:0002953)2.51780331
48Myocardial infarction (HP:0001658)2.51701025
49Vascular calcification (HP:0004934)2.50085908
50Cone-rod dystrophy (HP:0000548)2.48045185
51Obstructive lung disease (HP:0006536)2.45030777
52Chronic obstructive pulmonary disease (HP:0006510)2.45030777
53Conjugated hyperbilirubinemia (HP:0002908)2.44710843
54Hyperlipoproteinemia (HP:0010980)2.43167520
55Abnormality of monocarboxylic acid metabolism (HP:0010996)2.42951691
56Joint hemorrhage (HP:0005261)2.38661763
57Nasal polyposis (HP:0100582)2.37712259
58Abnormality of the common coagulation pathway (HP:0010990)2.35968460
59Gingivitis (HP:0000230)2.34702353
60Cardiovascular calcification (HP:0011915)2.30224057
61Entropion (HP:0000621)2.30137493
62Hepatosplenomegaly (HP:0001433)2.27372818
63Abnormality of iron homeostasis (HP:0011031)2.24796463
64Hypoalphalipoproteinemia (HP:0003233)2.24073458
65Enlarged epiphyses (HP:0010580)2.23901404
66Decreased subcutaneous fat (HP:0001002)2.23736790
67Bone pain (HP:0002653)2.23496867
68Mitral stenosis (HP:0001718)2.23100380
69Abnormality of complement system (HP:0005339)2.22995204
70Increased mean platelet volume (HP:0011877)2.22775293
71Prolonged partial thromboplastin time (HP:0003645)2.22703322
72Abnormal platelet volume (HP:0011876)2.22015246
73Nephritis (HP:0000123)2.21739440
74Upper motor neuron abnormality (HP:0002127)2.20155262
75Abnormality of aromatic amino acid family metabolism (HP:0004338)2.19008368
76Pathologic fracture (HP:0002756)2.18979215
77Protuberant abdomen (HP:0001538)2.18767313
78* Abnormality of sulfur amino acid metabolism (HP:0004339)2.17622597
79Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.17216149
80Hematochezia (HP:0002573)2.16300305
81Metaphyseal irregularity (HP:0003025)2.16251196
82Abnormality of the intrinsic pathway (HP:0010989)2.16237582
83Hemorrhage of the eye (HP:0011885)2.16014073
84Disinhibition (HP:0000734)2.15692239
85Tetany (HP:0001281)2.14504245
86Neurofibrillary tangles (HP:0002185)2.13008331
87Hypoglycemic coma (HP:0001325)2.12386713
88Increased CSF protein (HP:0002922)2.11909008
89Thick nail (HP:0001805)2.11387093
90Abnormal trabecular bone morphology (HP:0100671)2.10425974
91Abnormality of purine metabolism (HP:0004352)2.10253762
92Hyperglycinuria (HP:0003108)2.09537407
93Cerebral inclusion bodies (HP:0100314)2.09147977
94Bulbar palsy (HP:0001283)2.08076100
95Retinal atrophy (HP:0001105)2.05686463
96Fat malabsorption (HP:0002630)2.05356640
97Epidermoid cyst (HP:0200040)2.04763293
98Ketosis (HP:0001946)2.04184159
99Asymmetric septal hypertrophy (HP:0001670)2.03492165
100Conjunctival telangiectasia (HP:0000524)2.03280760
101Tetraparesis (HP:0002273)2.01585459
102Gingival bleeding (HP:0000225)2.01439611
103Erythroderma (HP:0001019)1.98857715
104Recurrent skin infections (HP:0001581)1.97816183
105Esophageal varix (HP:0002040)1.97740638
106Joint stiffness (HP:0001387)1.96706848
107Congenital ichthyosiform erythroderma (HP:0007431)1.95620034
108Impaired platelet aggregation (HP:0003540)1.94076051
109Abnormal platelet function (HP:0011869)1.94076051
110Abnormality of glycine metabolism (HP:0010895)1.92179020
111Abnormality of serine family amino acid metabolism (HP:0010894)1.92179020
112Ragged-red muscle fibers (HP:0003200)1.90607688
113Thoracic kyphosis (HP:0002942)1.90363932
114Hepatocellular carcinoma (HP:0001402)1.88801005
115Abnormality of transition element cation homeostasis (HP:0011030)1.87193219
116Distal lower limb muscle weakness (HP:0009053)1.86876997
117Hypertriglyceridemia (HP:0002155)1.86739973
118Increased IgM level (HP:0003496)1.86657144
119Mutism (HP:0002300)1.86415334
120Amyloidosis (HP:0011034)1.84297533
121Steatorrhea (HP:0002570)1.83818964
122Peripheral demyelination (HP:0011096)1.83346964
123Death in childhood (HP:0003819)1.83137939
124Aortic aneurysm (HP:0004942)1.83120210
125Abnormality of the lumbar spine (HP:0100712)1.82807283
126Poikiloderma (HP:0001029)1.82329356
127Abnormality of methionine metabolism (HP:0010901)1.80375047
128Ketoacidosis (HP:0001993)1.79491781
129Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79399095
130Hypoglycemic seizures (HP:0002173)1.79028334
131Colitis (HP:0002583)1.78439810
132Sensorimotor neuropathy (HP:0007141)1.77855147
133Autoimmune thrombocytopenia (HP:0001973)1.77349509
134Skin nodule (HP:0200036)1.77217898
135Upper limb amyotrophy (HP:0009129)1.77011129
136Distal upper limb amyotrophy (HP:0007149)1.77011129
137Mesangial abnormality (HP:0001966)1.75752450
138Coarse hair (HP:0002208)1.75415163
139Urticaria (HP:0001025)1.74382576
140Apathy (HP:0000741)1.73368941
141Diminished motivation (HP:0000745)1.73315996
142Abnormality of the thoracic spine (HP:0100711)1.72962524
143Menorrhagia (HP:0000132)1.72396879
144Ovoid vertebral bodies (HP:0003300)1.72120766
145Cardiomegaly (HP:0001640)1.71556262
146Abnormality of lateral ventricle (HP:0030047)1.70781047
147Rough bone trabeculation (HP:0100670)1.70507387
148Dementia (HP:0000726)1.69416278
149* Abnormality of fatty-acid metabolism (HP:0004359)1.69069172
150Hypercholesterolemia (HP:0003124)1.68283936
151Prominent metopic ridge (HP:0005487)1.68024029
152Polygenic inheritance (HP:0010982)1.63153488
153Zonular cataract (HP:0010920)1.62538799
154Hypertensive crisis (HP:0100735)1.60797061
155Thrombocytosis (HP:0001894)1.59103621
156Paralysis (HP:0003470)1.59032858
157Hand muscle atrophy (HP:0009130)1.59015066
158Neuronal loss in central nervous system (HP:0002529)1.58839306
159Widely patent fontanelles and sutures (HP:0004492)1.58638482
160Polycythemia (HP:0001901)1.58393366

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN15.38288439
2TESK13.41397219
3NME23.39617132
4INSRR3.29886024
5AKT33.22720639
6DDR23.18157251
7TAOK23.16762028
8TAOK32.88040269
9SIK12.70426281
10TGFBR22.63832553
11BCKDK2.51015025
12IRAK32.48771528
13TESK22.25330936
14MAP3K112.21703716
15PRKG22.20640498
16IRAK41.91655832
17IRAK21.90960588
18EPHB11.85996025
19BLK1.80972704
20TYK21.71865510
21TRPM71.67778401
22TAOK11.66040313
23TRIB31.63430596
24FRK1.59661554
25MAP3K11.59611991
26PTK61.53610342
27PDK21.47362421
28TBK11.46460197
29JAK11.45531217
30CSK1.41973135
31EPHA31.39935897
32CAMK1G1.39375403
33NUAK11.39248523
34ITK1.28660736
35MAP4K11.26615335
36MAP3K141.24801621
37ARAF1.23236934
38MAP2K21.23188297
39SMG11.23027685
40ABL21.22188144
41ICK1.21068730
42RIPK11.19932401
43FGFR41.18888867
44PRPF4B1.17991581
45MAP3K51.17967065
46CSF1R1.17451815
47PLK41.15616796
48MAP3K31.12332416
49CDC42BPA1.11314758
50PRKD31.09214477
51PRKD21.06529636
52TEC1.05394121
53KDR1.05208179
54SGK21.04990441
55SGK31.03414951
56JAK21.03335788
57CAMK1D1.03268187
58JAK31.03234326
59LATS11.02708958
60MST41.02509749
61PINK11.01741520
62BMPR1B0.99637128
63MAPK150.95707459
64BMX0.92740950
65MAP2K30.92061158
66RIPK40.91534692
67MAP3K80.91498068
68BTK0.91456135
69PTK20.91423944
70MOS0.91142973
71IKBKB0.89735794
72TTN0.87085386
73ZAP700.86130714
74MARK30.85657517
75STK380.84490699
76CDK120.81788920
77STK100.80726990
78PAK40.79717351
79DYRK1B0.78086550
80MAP2K60.77112161
81CHUK0.75949346
82BRAF0.75341651
83FGR0.75034146
84MAP3K20.74674447
85PDGFRA0.73636764
86SCYL20.72037052
87LIMK10.70119845
88SGK4940.68547277
89SGK2230.68547277
90PRKCH0.68290853
91GRK60.67725846
92MAP3K130.67695817
93MET0.67636499
94PAK10.65963204
95GRK70.64160748
96RPS6KC10.64000039
97RPS6KL10.64000039
98MAPK120.63655280
99PIK3CG0.61277452
100NEK60.60749791
101STK38L0.59294445
102OXSR10.58190531
103STK30.57717406
104IRAK10.57340883
105IKBKE0.57241524
106MARK20.55043615
107RPS6KA20.54219237
108PDPK10.53332536
109SYK0.52975294
110KIT0.52380023
111MAPKAPK30.52245330
112PDGFRB0.51968659
113YES10.51871714
114BMPR20.51611900
115KSR20.51147527
116MAPK110.49751421
117CDK90.49744445
118HCK0.49502612
119LMTK20.48563613
120BRD40.48180482
121IGF1R0.48146154
122MYLK0.47939023
123NEK90.47788682
124TIE10.47370956
125FGFR10.47155328
126MAPK70.47060409
127LYN0.46736485
128MTOR0.46509624
129TLK10.46065865
130PIM20.45623637
131MAPKAPK20.44172369
132RPS6KA60.43837216
133TYRO30.41758275
134FLT30.40710925
135EEF2K0.40661970
136MST1R0.39755025
137PAK20.37801833
138PTK2B0.36529665
139MATK0.35296693
140CDK70.34425648
141STK160.33945122
142INSR0.33910854
143PRKD10.33583146
144EGFR0.32750790
145TNK20.31339246
146PDK10.30436450
147LCK0.30059540

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005113.00916881
2Staphylococcus aureus infection_Homo sapiens_hsa051502.86617473
3Glycosaminoglycan degradation_Homo sapiens_hsa005312.75763081
4* Lysosome_Homo sapiens_hsa041422.75607682
5Primary bile acid biosynthesis_Homo sapiens_hsa001202.17673839
6Complement and coagulation cascades_Homo sapiens_hsa046102.07152771
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.96877519
8Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89730388
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.88836635
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.85042463
11Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.84001621
12Fatty acid degradation_Homo sapiens_hsa000711.77473131
13Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68135990
14Sulfur metabolism_Homo sapiens_hsa009201.64568115
15Hematopoietic cell lineage_Homo sapiens_hsa046401.64553924
16Vitamin B6 metabolism_Homo sapiens_hsa007501.64299502
17Steroid biosynthesis_Homo sapiens_hsa001001.62493636
18Tryptophan metabolism_Homo sapiens_hsa003801.53468423
19Fatty acid metabolism_Homo sapiens_hsa012121.46302318
20PPAR signaling pathway_Homo sapiens_hsa033201.42581671
21ABC transporters_Homo sapiens_hsa020101.38118424
22Sulfur relay system_Homo sapiens_hsa041221.36048956
23Peroxisome_Homo sapiens_hsa041461.33769044
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.29244952
25Platelet activation_Homo sapiens_hsa046111.25683708
26Phagosome_Homo sapiens_hsa041451.24698494
27Starch and sucrose metabolism_Homo sapiens_hsa005001.24025470
28Acute myeloid leukemia_Homo sapiens_hsa052211.23877135
29Histidine metabolism_Homo sapiens_hsa003401.23382155
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.22176483
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.22107049
32Leishmaniasis_Homo sapiens_hsa051401.19764899
33Salmonella infection_Homo sapiens_hsa051321.19155643
34Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19065742
35Arginine biosynthesis_Homo sapiens_hsa002201.15521076
36Endocytosis_Homo sapiens_hsa041441.13962107
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.13513149
38Fat digestion and absorption_Homo sapiens_hsa049751.13494572
39Caffeine metabolism_Homo sapiens_hsa002321.12867266
40Vitamin digestion and absorption_Homo sapiens_hsa049771.12381078
41Shigellosis_Homo sapiens_hsa051311.11523026
42Notch signaling pathway_Homo sapiens_hsa043301.11457913
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.11341245
44Rheumatoid arthritis_Homo sapiens_hsa053231.10682881
45Fatty acid biosynthesis_Homo sapiens_hsa000611.10559518
46Antigen processing and presentation_Homo sapiens_hsa046121.10349212
47Allograft rejection_Homo sapiens_hsa053301.06075894
48Malaria_Homo sapiens_hsa051441.05179434
49Legionellosis_Homo sapiens_hsa051341.04618997
50Lysine degradation_Homo sapiens_hsa003101.00551199
51beta-Alanine metabolism_Homo sapiens_hsa004100.99229414
52Chemical carcinogenesis_Homo sapiens_hsa052040.99136955
53Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.97961475
54Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.97806279
55Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.97796380
56Retinol metabolism_Homo sapiens_hsa008300.96981929
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.96867553
58Fructose and mannose metabolism_Homo sapiens_hsa000510.96826919
59Herpes simplex infection_Homo sapiens_hsa051680.94165413
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92972904
61Nitrogen metabolism_Homo sapiens_hsa009100.92657066
62Propanoate metabolism_Homo sapiens_hsa006400.92511443
63Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.91352909
64B cell receptor signaling pathway_Homo sapiens_hsa046620.90571914
65Protein export_Homo sapiens_hsa030600.90362307
66Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.89343372
67Osteoclast differentiation_Homo sapiens_hsa043800.88221253
68Steroid hormone biosynthesis_Homo sapiens_hsa001400.87612075
69Chemokine signaling pathway_Homo sapiens_hsa040620.86677486
70Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86075020
71Selenocompound metabolism_Homo sapiens_hsa004500.85762608
72Renin-angiotensin system_Homo sapiens_hsa046140.85758901
73Autoimmune thyroid disease_Homo sapiens_hsa053200.85456564
74Measles_Homo sapiens_hsa051620.85040496
75Viral myocarditis_Homo sapiens_hsa054160.84674088
76Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83914817
77Galactose metabolism_Homo sapiens_hsa000520.82523083
78Tuberculosis_Homo sapiens_hsa051520.81415075
79Fatty acid elongation_Homo sapiens_hsa000620.81306413
80Insulin resistance_Homo sapiens_hsa049310.80765670
81Pertussis_Homo sapiens_hsa051330.79439344
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78856345
83Glycerophospholipid metabolism_Homo sapiens_hsa005640.78162250
84Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.75024005
85Hepatitis C_Homo sapiens_hsa051600.74924970
86Bile secretion_Homo sapiens_hsa049760.74467490
87Butanoate metabolism_Homo sapiens_hsa006500.74385379
88Sphingolipid metabolism_Homo sapiens_hsa006000.73839920
89Graft-versus-host disease_Homo sapiens_hsa053320.73425887
90Toxoplasmosis_Homo sapiens_hsa051450.73385756
91Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72714548
92Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.72672765
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.72635560
94SNARE interactions in vesicular transport_Homo sapiens_hsa041300.72066691
95Hepatitis B_Homo sapiens_hsa051610.70749497
96Prion diseases_Homo sapiens_hsa050200.70720438
97N-Glycan biosynthesis_Homo sapiens_hsa005100.70068699
98Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.69962741
99NF-kappa B signaling pathway_Homo sapiens_hsa040640.69822771
100Amoebiasis_Homo sapiens_hsa051460.69715404
101Collecting duct acid secretion_Homo sapiens_hsa049660.69605790
102Asthma_Homo sapiens_hsa053100.68172067
103Glycerolipid metabolism_Homo sapiens_hsa005610.66996291
104Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.66762361
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.65509532
106Vibrio cholerae infection_Homo sapiens_hsa051100.65178862
107NOD-like receptor signaling pathway_Homo sapiens_hsa046210.64639773
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.62605646
109Apoptosis_Homo sapiens_hsa042100.62066665
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60137878
111Phenylalanine metabolism_Homo sapiens_hsa003600.59556523
112Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.59484090
113Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.58806123
114Arginine and proline metabolism_Homo sapiens_hsa003300.58028554
115Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57962475
116VEGF signaling pathway_Homo sapiens_hsa043700.57305683
117Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56785560
118Influenza A_Homo sapiens_hsa051640.55954387
1192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55847916
120Drug metabolism - other enzymes_Homo sapiens_hsa009830.55244694
121Leukocyte transendothelial migration_Homo sapiens_hsa046700.54407123
122Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.53999923
123Dorso-ventral axis formation_Homo sapiens_hsa043200.52940900
124Jak-STAT signaling pathway_Homo sapiens_hsa046300.52860497
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.52502296
126ECM-receptor interaction_Homo sapiens_hsa045120.52003792
127Prostate cancer_Homo sapiens_hsa052150.51072029
128Glutathione metabolism_Homo sapiens_hsa004800.49845011
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.49827557
130T cell receptor signaling pathway_Homo sapiens_hsa046600.49351092
131Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.48880856
132TNF signaling pathway_Homo sapiens_hsa046680.48804084
133Arachidonic acid metabolism_Homo sapiens_hsa005900.48567887
134Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48151244
135Chronic myeloid leukemia_Homo sapiens_hsa052200.47846038
136Regulation of actin cytoskeleton_Homo sapiens_hsa048100.47446348
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.47417398
138Pancreatic cancer_Homo sapiens_hsa052120.46163039
139Primary immunodeficiency_Homo sapiens_hsa053400.45062011
140Protein digestion and absorption_Homo sapiens_hsa049740.43773773
141Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.42367835
142African trypanosomiasis_Homo sapiens_hsa051430.41964762
143AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.41845805
144Bladder cancer_Homo sapiens_hsa052190.41492599
145Adipocytokine signaling pathway_Homo sapiens_hsa049200.41470393
146Intestinal immune network for IgA production_Homo sapiens_hsa046720.41019999
147Neurotrophin signaling pathway_Homo sapiens_hsa047220.40992193
148Viral carcinogenesis_Homo sapiens_hsa052030.40390380
149Focal adhesion_Homo sapiens_hsa045100.39142146
150Inositol phosphate metabolism_Homo sapiens_hsa005620.38875768
151Renal cell carcinoma_Homo sapiens_hsa052110.35530100

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