CTR9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of the PAF1 complex, which associates with RNA polymerase II and functions in transcriptional regulation and elongation. This complex also plays a role in the modification of histones. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1central nervous system myelination (GO:0022010)9.46736772
2axon ensheathment in central nervous system (GO:0032291)9.46736772
3axon ensheathment (GO:0008366)6.46207289
4ensheathment of neurons (GO:0007272)6.46207289
5myelination (GO:0042552)6.45542218
6fatty acid elongation (GO:0030497)6.29981647
7regulation of DNA endoreduplication (GO:0032875)5.67655087
8apical protein localization (GO:0045176)4.73183485
9mitotic sister chromatid cohesion (GO:0007064)4.65978179
10long-chain fatty acid biosynthetic process (GO:0042759)4.62408623
11mitotic sister chromatid segregation (GO:0000070)4.58630769
12asymmetric protein localization (GO:0008105)4.51619749
13nuclear pore organization (GO:0006999)4.48081326
14regulation of collateral sprouting (GO:0048670)4.45478282
15maturation of 5.8S rRNA (GO:0000460)4.38736709
16negative regulation of neurotransmitter secretion (GO:0046929)4.37259558
17myelin maintenance (GO:0043217)4.36955687
18sister chromatid segregation (GO:0000819)4.36069192
19astrocyte development (GO:0014002)4.35635102
20establishment of integrated proviral latency (GO:0075713)4.34829675
21regulation of sister chromatid cohesion (GO:0007063)4.28300253
22cholesterol biosynthetic process (GO:0006695)4.27782536
23mitotic metaphase plate congression (GO:0007080)4.26536685
24establishment of mitochondrion localization (GO:0051654)4.24071555
25positive regulation of mitotic sister chromatid separation (GO:1901970)4.19546818
26positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.19546818
27positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.19546818
28oligodendrocyte differentiation (GO:0048709)4.10736196
29cerebral cortex radially oriented cell migration (GO:0021799)4.06554659
30meiotic chromosome segregation (GO:0045132)3.97589279
31limb bud formation (GO:0060174)3.93772419
32negative regulation of neurotransmitter transport (GO:0051589)3.87077576
33microtubule polymerization or depolymerization (GO:0031109)3.85572361
34double-strand break repair via nonhomologous end joining (GO:0006303)3.83840690
35non-recombinational repair (GO:0000726)3.83840690
36myelination in peripheral nervous system (GO:0022011)3.83312901
37peripheral nervous system axon ensheathment (GO:0032292)3.83312901
38positive regulation of oligodendrocyte differentiation (GO:0048714)3.78478743
39rRNA catabolic process (GO:0016075)3.73920871
40sterol biosynthetic process (GO:0016126)3.71730214
41histone-serine phosphorylation (GO:0035404)3.71560108
42glycerophospholipid catabolic process (GO:0046475)3.69463301
43eye photoreceptor cell differentiation (GO:0001754)3.68357462
44photoreceptor cell differentiation (GO:0046530)3.68357462
45regulation of centrosome cycle (GO:0046605)3.67750647
46DNA strand elongation involved in DNA replication (GO:0006271)3.65060654
47mitotic chromosome condensation (GO:0007076)3.64333620
48protein localization to microtubule cytoskeleton (GO:0072698)3.63907802
49sister chromatid cohesion (GO:0007062)3.62534924
50DNA strand elongation (GO:0022616)3.59112095
51DNA topological change (GO:0006265)3.58183021
52metaphase plate congression (GO:0051310)3.57730803
53negative regulation of peptidyl-threonine phosphorylation (GO:0010801)3.57256952
54positive regulation of chromosome segregation (GO:0051984)3.55818991
55protein localization to kinetochore (GO:0034501)3.54858852
56spliceosomal snRNP assembly (GO:0000387)3.49714827
57chromosome segregation (GO:0007059)3.48127754
58protein localization to chromosome (GO:0034502)3.47399824
59pore complex assembly (GO:0046931)3.40746275
60nucleobase biosynthetic process (GO:0046112)3.40226256
61presynaptic membrane organization (GO:0097090)3.35801935
62negative regulation of DNA-dependent DNA replication (GO:2000104)3.35695887
63DNA replication initiation (GO:0006270)3.35466087
64regulation of spindle organization (GO:0090224)3.34849117
65negative regulation of protein localization to cell surface (GO:2000009)3.32302378
66isoprenoid biosynthetic process (GO:0008299)3.31271977
67regulation of meiosis I (GO:0060631)3.30941993
68reciprocal meiotic recombination (GO:0007131)3.29535568
69reciprocal DNA recombination (GO:0035825)3.29535568
70protein localization to chromosome, centromeric region (GO:0071459)3.27939366
71mitotic spindle organization (GO:0007052)3.27015579
72purine nucleobase biosynthetic process (GO:0009113)3.24191674
73formation of translation preinitiation complex (GO:0001731)3.21123307
74CENP-A containing nucleosome assembly (GO:0034080)3.19854307
75establishment of chromosome localization (GO:0051303)3.18999948
76protein localization to cytoskeleton (GO:0044380)3.16063995
77microtubule depolymerization (GO:0007019)3.15893902
78chromatin remodeling at centromere (GO:0031055)3.15797324
79presynaptic membrane assembly (GO:0097105)3.14524469
80DNA replication checkpoint (GO:0000076)3.14243094
81long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)3.12387545
82acrosome assembly (GO:0001675)3.12043342
83mitotic G2/M transition checkpoint (GO:0044818)3.10219302
84negative regulation of axonogenesis (GO:0050771)3.09438234
85spindle checkpoint (GO:0031577)3.06578502
86mitotic spindle checkpoint (GO:0071174)3.06273696
87pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.04667457
88negative regulation of axon extension involved in axon guidance (GO:0048843)3.02171350
89kinetochore organization (GO:0051383)3.02108815
90termination of RNA polymerase II transcription (GO:0006369)3.01259229
91mitotic nuclear envelope disassembly (GO:0007077)3.01105063
92regulation of chromosome segregation (GO:0051983)3.01028693
93glial cell development (GO:0021782)3.00612351
94establishment of viral latency (GO:0019043)3.00261461
95pre-miRNA processing (GO:0031054)2.99108985
96RNA splicing, via transesterification reactions (GO:0000375)2.98052839
97substantia nigra development (GO:0021762)2.97865865
98negative regulation of axon extension (GO:0030517)2.95127069
99regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93914228
100regulation of mitotic metaphase/anaphase transition (GO:0030071)2.93914228
101spliceosomal complex assembly (GO:0000245)2.92866075
102amyloid precursor protein metabolic process (GO:0042982)2.92769051
103ribosome assembly (GO:0042255)2.92717801
104spindle organization (GO:0007051)2.92101820
105* positive regulation of histone H3-K4 methylation (GO:0051571)2.90264531
106regulation of spindle checkpoint (GO:0090231)2.89251792
107response to methylmercury (GO:0051597)2.89181340
108response to hepatocyte growth factor (GO:0035728)2.88611672
109cellular response to hepatocyte growth factor stimulus (GO:0035729)2.88611672
110DNA double-strand break processing (GO:0000729)2.88551622
111DNA catabolic process, exonucleolytic (GO:0000738)2.88138559
112positive regulation of actin filament depolymerization (GO:0030836)2.87838359
113positive regulation of neurological system process (GO:0031646)2.86664608
114regulation of sister chromatid segregation (GO:0033045)2.85882563
115regulation of mitotic sister chromatid separation (GO:0010965)2.85882563
116regulation of mitotic sister chromatid segregation (GO:0033047)2.85882563
117regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.85802297
118long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.85599692
119spindle assembly (GO:0051225)2.84925813
120RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84791264
121tetrahydrofolate metabolic process (GO:0046653)2.84200441
122response to redox state (GO:0051775)2.84049168
123ear development (GO:0043583)2.83373541
124response to lipoprotein particle (GO:0055094)2.82849622
125negative regulation of chromosome segregation (GO:0051985)2.82298767
126nuclear envelope disassembly (GO:0051081)2.82070200
127membrane disassembly (GO:0030397)2.82070200
128anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.81674287
129RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.81232143
130mRNA splicing, via spliceosome (GO:0000398)2.81232143
131DNA replication-independent nucleosome assembly (GO:0006336)2.80626260
132DNA replication-independent nucleosome organization (GO:0034724)2.80626260
133Leydig cell differentiation (GO:0033327)2.79864489
134histone mRNA metabolic process (GO:0008334)2.79505489
135mitotic spindle assembly checkpoint (GO:0007094)2.79406791
136peptidyl-tyrosine autophosphorylation (GO:0038083)2.78395761
137spindle assembly checkpoint (GO:0071173)2.77776540
138negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74540622
139negative regulation of mitotic sister chromatid separation (GO:2000816)2.74540622
140negative regulation of sister chromatid segregation (GO:0033046)2.74540622
141negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74540622
142negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.74540622
143glycerol ether metabolic process (GO:0006662)2.73447375
144viral mRNA export from host cell nucleus (GO:0046784)2.72718714
145rRNA methylation (GO:0031167)2.72091788
146histone exchange (GO:0043486)2.70502368
147postreplication repair (GO:0006301)2.70204464
148protein palmitoylation (GO:0018345)2.66622075
149rRNA processing (GO:0006364)2.66409333
150negative regulation of axon guidance (GO:1902668)2.64881550
151lateral sprouting from an epithelium (GO:0060601)2.61203762
152* histone H2B ubiquitination (GO:0033523)2.61033495
153organ growth (GO:0035265)2.60009112
154DNA unwinding involved in DNA replication (GO:0006268)2.57335371
155regulation of RNA export from nucleus (GO:0046831)2.56964989
156regulation of somitogenesis (GO:0014807)2.53301471
157negative regulation of JUN kinase activity (GO:0043508)2.49247564
158regulation of myelination (GO:0031641)2.48747913
159establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.48184780
160mitochondrion transport along microtubule (GO:0047497)2.48184780
161enteric nervous system development (GO:0048484)2.47275142
162positive regulation of cell cycle checkpoint (GO:1901978)2.46561632
163adhesion of symbiont to host cell (GO:0044650)2.46502873
164virion attachment to host cell (GO:0019062)2.46502873
165fatty-acyl-CoA biosynthetic process (GO:0046949)2.45198195
166cranial nerve morphogenesis (GO:0021602)2.44692475
167transmission of nerve impulse (GO:0019226)2.43980901
168establishment of mitotic spindle orientation (GO:0000132)2.43603987
169cell migration in hindbrain (GO:0021535)2.39611093
170axon development (GO:0061564)2.38903852
171negative regulation of execution phase of apoptosis (GO:1900118)2.38206838
172estrogen biosynthetic process (GO:0006703)2.37901720
173GPI anchor biosynthetic process (GO:0006506)2.37874881
174regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.36607909
175magnesium ion transport (GO:0015693)2.35560839
176spinal cord motor neuron differentiation (GO:0021522)2.34160123
177positive regulation of action potential (GO:0045760)2.32968788
178membrane tubulation (GO:0097320)2.32726789
179nuclear pore complex assembly (GO:0051292)2.31730588
180import into cell (GO:0098657)2.31065477
181glial cell differentiation (GO:0010001)2.30825179
182GPI anchor metabolic process (GO:0006505)2.29811443
183polarized epithelial cell differentiation (GO:0030859)2.29652397
184establishment of mitotic spindle localization (GO:0040001)2.29218630
185regulation of rhodopsin mediated signaling pathway (GO:0022400)2.28540127
186DNA ligation (GO:0006266)2.27885691
187neural nucleus development (GO:0048857)2.26890400
188neuron recognition (GO:0008038)2.26752147
189creatine metabolic process (GO:0006600)2.26172437
190cerebral cortex cell migration (GO:0021795)2.23293178
191establishment of spindle orientation (GO:0051294)2.22998505
192camera-type eye morphogenesis (GO:0048593)2.22843523
193DNA methylation involved in gamete generation (GO:0043046)2.22804224
194positive regulation of glial cell differentiation (GO:0045687)2.21920852
195cranial suture morphogenesis (GO:0060363)2.21253518
196somite development (GO:0061053)2.20008441
197regulation of nucleobase-containing compound transport (GO:0032239)2.19542618

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat4.03944780
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.79249777
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.46015194
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.35801619
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.24678532
6MYC_18555785_ChIP-Seq_MESCs_Mouse3.21890678
7HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21407700
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.10502115
9RBPJ_22232070_ChIP-Seq_NCS_Mouse3.07297609
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.00464987
11PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.94466741
12FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.87474867
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.86229236
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.65692464
15GBX2_23144817_ChIP-Seq_PC3_Human2.61934947
16ELK1_19687146_ChIP-ChIP_HELA_Human2.61061780
17MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.55897187
18POU5F1_16153702_ChIP-ChIP_HESCs_Human2.39352562
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.34659556
20SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse2.29748403
21VDR_23849224_ChIP-Seq_CD4+_Human2.29338693
22PADI4_21655091_ChIP-ChIP_MCF-7_Human2.24237882
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.21672781
24ETS1_20019798_ChIP-Seq_JURKAT_Human2.19933589
25MYC_19030024_ChIP-ChIP_MESCs_Mouse2.17155319
26WT1_19549856_ChIP-ChIP_CCG9911_Human2.16769225
27FUS_26573619_Chip-Seq_HEK293_Human2.14386072
28* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.13654658
29STAT6_21828071_ChIP-Seq_BEAS2B_Human2.10112012
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.09700172
31TAF15_26573619_Chip-Seq_HEK293_Human2.09382806
32MYC_19079543_ChIP-ChIP_MESCs_Mouse2.08665100
33DCP1A_22483619_ChIP-Seq_HELA_Human2.07875409
34FOXP3_21729870_ChIP-Seq_TREG_Human2.07363587
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.06019367
36E2F1_21310950_ChIP-Seq_MCF-7_Human2.05473097
37SOX2_16153702_ChIP-ChIP_HESCs_Human1.97045682
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.91189011
39MYCN_18555785_ChIP-Seq_MESCs_Mouse1.91112587
40KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.91063543
41KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.91063543
42KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.91063543
43* TTF2_22483619_ChIP-Seq_HELA_Human1.90439958
44CBX2_27304074_Chip-Seq_ESCs_Mouse1.90189643
45* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89401645
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.87683810
47STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.83701490
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.83343764
49E2F7_22180533_ChIP-Seq_HELA_Human1.82126410
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81979768
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.79386889
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.77358072
53HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.70981762
54RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.65113709
55CIITA_25753668_ChIP-Seq_RAJI_Human1.64312550
56CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.63797762
57RNF2_27304074_Chip-Seq_NSC_Mouse1.63219168
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.62698647
59XRN2_22483619_ChIP-Seq_HELA_Human1.59705242
60* GABP_19822575_ChIP-Seq_HepG2_Human1.59031697
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.56937840
62AR_21909140_ChIP-Seq_LNCAP_Human1.55651368
63EWS_26573619_Chip-Seq_HEK293_Human1.54343842
64PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.52806667
65IRF1_19129219_ChIP-ChIP_H3396_Human1.50144944
66VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.50043481
67SMAD3_21741376_ChIP-Seq_EPCs_Human1.49896215
68E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48765798
69BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47564573
70* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45156316
71EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.44880131
72POU3F2_20337985_ChIP-ChIP_501MEL_Human1.44754327
73ER_23166858_ChIP-Seq_MCF-7_Human1.44322399
74GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39304374
75HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.39183144
76TFEB_21752829_ChIP-Seq_HELA_Human1.38378694
77MYC_18940864_ChIP-ChIP_HL60_Human1.38298249
78CTBP1_25329375_ChIP-Seq_LNCAP_Human1.36445242
79RING1B_27294783_Chip-Seq_NPCs_Mouse1.35555260
80JARID2_20064375_ChIP-Seq_MESCs_Mouse1.34695296
81KDM5A_27292631_Chip-Seq_BREAST_Human1.32413403
82VDR_22108803_ChIP-Seq_LS180_Human1.32224584
83ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31196091
84* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31030983
85ZFP57_27257070_Chip-Seq_ESCs_Mouse1.30852305
86SOX9_26525672_Chip-Seq_Limbbuds_Mouse1.30321510
87TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29221486
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.28782849
89CTBP2_25329375_ChIP-Seq_LNCAP_Human1.27721961
90YY1_21170310_ChIP-Seq_MESCs_Mouse1.26513804
91SRF_21415370_ChIP-Seq_HL-1_Mouse1.24761031
92SOX9_26525672_Chip-Seq_HEART_Mouse1.24512800
93PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.24272527
94EED_16625203_ChIP-ChIP_MESCs_Mouse1.24140930
95CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24102935
96ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23508474
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22980633
98THAP11_20581084_ChIP-Seq_MESCs_Mouse1.22520921
99RNF2_27304074_Chip-Seq_ESCs_Mouse1.22183319
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19472589
101ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.19257877
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.18351174
103POU3F1_26484290_ChIP-Seq_ESCss_Mouse1.18151613
104DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.12837282
105MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.12398676
106P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11933802
107EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11178408
108RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11178408
109SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.10828782
110* STAT3_23295773_ChIP-Seq_U87_Human1.09061078
111* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.08216021
112OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.07973982
113GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07818375
114SOX17_20123909_ChIP-Seq_XEN_Mouse1.07752982
115TCF3_18692474_ChIP-Seq_MESCs_Mouse1.07577778
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.07356746
117* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.05995694
118* TCF4_23295773_ChIP-Seq_U87_Human1.05233603
119SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.04644302
120TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.04538931
121TBL1_22424771_ChIP-Seq_293T_Human1.04276989
122NOTCH1_21737748_ChIP-Seq_TLL_Human1.03967526
123E2F4_17652178_ChIP-ChIP_JURKAT_Human1.02561178
124EGR1_19374776_ChIP-ChIP_THP-1_Human1.02096347
125* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.02081594
126NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.01669056
127* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.01358158
128TP63_19390658_ChIP-ChIP_HaCaT_Human1.01311683
129CMYC_18555785_Chip-Seq_ESCs_Mouse1.00308035
130* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99528481
131NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99483717
132SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.99136088
133POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.99054963
134LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98532290
135SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.97756747
136SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97435805
137SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97396614
138TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97289175
139IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96589856
140NANOG_18555785_Chip-Seq_ESCs_Mouse0.96579190
141MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.95857470
142TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.95662409
143CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.93947902
144SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93132567
145KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.91595371
146ISL1_27105846_Chip-Seq_CPCs_Mouse0.91416166
147FLI1_27457419_Chip-Seq_LIVER_Mouse0.91064527
148NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.90860689
149KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88994209
150YAP1_20516196_ChIP-Seq_MESCs_Mouse0.88544459
151WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.88387569
152RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88292056
153CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.86890995
154CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.85736999
155P300_18555785_Chip-Seq_ESCs_Mouse0.85533293
156NANOG_16153702_ChIP-ChIP_HESCs_Human0.85351267
157YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.85334276
158SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.85236526
159AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85195054
160SUZ12_18555785_Chip-Seq_ESCs_Mouse0.85174189
161FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.84911628
162CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.84902756
163SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84769545
164P300_19829295_ChIP-Seq_ESCs_Human0.84769491
165TOP2B_26459242_ChIP-Seq_MCF-7_Human0.84473570
166JARID2_20075857_ChIP-Seq_MESCs_Mouse0.84337731
167PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.83416317
168SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81834903
169RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.79493753
170SPI1_23547873_ChIP-Seq_NB4_Human0.78429604
171POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.78201031
172BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.77191948
173CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.74084664
174ZNF274_21170338_ChIP-Seq_K562_Hela0.74028374
175* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.71964499
176IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.71105755
177CBP_20019798_ChIP-Seq_JUKART_Human0.71105755

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.35076630
2MP0000920_abnormal_myelination3.65340079
3MP0008058_abnormal_DNA_repair3.58082029
4MP0003111_abnormal_nucleus_morphology3.55672914
5MP0003077_abnormal_cell_cycle3.42922169
6MP0004957_abnormal_blastocyst_morpholog3.23240204
7MP0008007_abnormal_cellular_replicative2.97967904
8MP0009697_abnormal_copulation2.82447737
9MP0000566_synostosis2.60453293
10MP0000778_abnormal_nervous_system2.53428447
11MP0004885_abnormal_endolymph2.47276478
12MP0005171_absent_coat_pigmentation2.46361188
13MP0008057_abnormal_DNA_replication2.27409193
14MP0001529_abnormal_vocalization2.23485495
15MP0004270_analgesia2.18974333
16MP0000462_abnormal_digestive_system2.09613700
17MP0004742_abnormal_vestibular_system2.08551551
18MP0005409_darkened_coat_color2.05148536
19MP0001485_abnormal_pinna_reflex2.05039467
20MP0003950_abnormal_plasma_membrane2.04258388
21MP0003718_maternal_effect2.00523222
22MP0005423_abnormal_somatic_nervous1.97952100
23MP0003937_abnormal_limbs/digits/tail_de1.96759669
24MP0003880_abnormal_central_pattern1.94329087
25MP0000383_abnormal_hair_follicle1.93466015
26MP0008877_abnormal_DNA_methylation1.93269085
27MP0000350_abnormal_cell_proliferation1.91118880
28MP0004134_abnormal_chest_morphology1.90791166
29MP0001905_abnormal_dopamine_level1.86184548
30MP0003136_yellow_coat_color1.84586358
31MP0010678_abnormal_skin_adnexa1.83601082
32MP0002938_white_spotting1.76024729
33MP0006072_abnormal_retinal_apoptosis1.75864246
34MP0006292_abnormal_olfactory_placode1.75134888
35MP0000537_abnormal_urethra_morphology1.72798535
36MP0003634_abnormal_glial_cell1.69684399
37MP0001697_abnormal_embryo_size1.63641018
38MP0003632_abnormal_nervous_system1.61358596
39MP0005410_abnormal_fertilization1.60345013
40MP0005623_abnormal_meninges_morphology1.60220764
41MP0003385_abnormal_body_wall1.59495498
42MP0003221_abnormal_cardiomyocyte_apopto1.56102957
43MP0005408_hypopigmentation1.54726090
44MP0010030_abnormal_orbit_morphology1.49492433
45MP0003121_genomic_imprinting1.49162743
46MP0001486_abnormal_startle_reflex1.45899616
47MP0003861_abnormal_nervous_system1.45685683
48MP0005551_abnormal_eye_electrophysiolog1.44613291
49MP0002272_abnormal_nervous_system1.41597307
50MP0003938_abnormal_ear_development1.39135305
51MP0001661_extended_life_span1.38459336
52MP0000955_abnormal_spinal_cord1.38113603
53MP0004142_abnormal_muscle_tone1.37265763
54MP0000372_irregular_coat_pigmentation1.35695668
55MP0003122_maternal_imprinting1.35181695
56MP0001293_anophthalmia1.33311639
57MP0002229_neurodegeneration1.32738585
58MP0003690_abnormal_glial_cell1.32702933
59MP0000569_abnormal_digit_pigmentation1.31467235
60MP0001672_abnormal_embryogenesis/_devel1.31413902
61MP0005380_embryogenesis_phenotype1.31413902
62MP0002080_prenatal_lethality1.31383746
63MP0002751_abnormal_autonomic_nervous1.30979019
64MP0002752_abnormal_somatic_nervous1.30794589
65MP0000631_abnormal_neuroendocrine_gland1.29803719
66MP0002882_abnormal_neuron_morphology1.29281991
67MP0005253_abnormal_eye_physiology1.28653196
68MP0000313_abnormal_cell_death1.28036689
69MP0010352_gastrointestinal_tract_polyps1.27997460
70MP0003890_abnormal_embryonic-extraembry1.26974581
71MP0002102_abnormal_ear_morphology1.25813998
72MP0004133_heterotaxia1.24587203
73MP0008789_abnormal_olfactory_epithelium1.24497299
74MP0008932_abnormal_embryonic_tissue1.24472991
75MP0003984_embryonic_growth_retardation1.24095148
76MP0006036_abnormal_mitochondrial_physio1.19578155
77MP0003183_abnormal_peptide_metabolism1.19468848
78MP0005195_abnormal_posterior_eye1.18901845
79MP0003755_abnormal_palate_morphology1.18209166
80MP0003186_abnormal_redox_activity1.18000828
81MP0002088_abnormal_embryonic_growth/wei1.17645283
82MP0002152_abnormal_brain_morphology1.15562075
83MP0005075_abnormal_melanosome_morpholog1.15412742
84MP0001963_abnormal_hearing_physiology1.10643261
85MP0003787_abnormal_imprinting1.10424048
86MP0008438_abnormal_cutaneous_collagen1.08687084
87MP0005395_other_phenotype1.08301870
88MP0005391_vision/eye_phenotype1.08075357
89MP0003763_abnormal_thymus_physiology1.06982802
90MP0010307_abnormal_tumor_latency1.06893414
91MP0010234_abnormal_vibrissa_follicle1.06848363
92MP0002233_abnormal_nose_morphology1.06793615
93MP0006035_abnormal_mitochondrial_morpho1.05832405
94MP0000428_abnormal_craniofacial_morphol1.05498851
95MP0010094_abnormal_chromosome_stability1.04541798
96MP0002019_abnormal_tumor_incidence1.03959212
97MP0004197_abnormal_fetal_growth/weight/1.03828482
98MP0009250_abnormal_appendicular_skeleto1.03539393
99MP0003698_abnormal_male_reproductive1.03444965
100MP0001299_abnormal_eye_distance/1.03060233
101MP0000358_abnormal_cell_content/1.03050233
102MP0004233_abnormal_muscle_weight1.02309662
103MP0003329_amyloid_beta_deposits1.01687278
104MP0003786_premature_aging1.00518564
105MP0001145_abnormal_male_reproductive1.00302574
106MP0000647_abnormal_sebaceous_gland0.99633216
107MP0002734_abnormal_mechanical_nocicepti0.98899856
108MP0000467_abnormal_esophagus_morphology0.97832414
109MP0002697_abnormal_eye_size0.97281942
110MP0000703_abnormal_thymus_morphology0.96928030
111MP0000653_abnormal_sex_gland0.96477382
112MP0004808_abnormal_hematopoietic_stem0.96285025
113MP0002084_abnormal_developmental_patter0.94948705
114MP0002085_abnormal_embryonic_tissue0.94420394
115MP0002184_abnormal_innervation0.92056258
116MP0001340_abnormal_eyelid_morphology0.91690248
117MP0000762_abnormal_tongue_morphology0.90228908
118MP0000026_abnormal_inner_ear0.90100077
119MP0002114_abnormal_axial_skeleton0.88867881
120MP0009703_decreased_birth_body0.88815851
121MP0005394_taste/olfaction_phenotype0.87764474
122MP0005499_abnormal_olfactory_system0.87764474
123MP0001929_abnormal_gametogenesis0.87503655
124MP0004272_abnormal_basement_membrane0.87066768
125MP0000490_abnormal_crypts_of0.86677502
126MP0000015_abnormal_ear_pigmentation0.86532680
127MP0002249_abnormal_larynx_morphology0.86443384
128MP0002116_abnormal_craniofacial_bone0.85551506
129MP0001730_embryonic_growth_arrest0.85506670
130MP0002086_abnormal_extraembryonic_tissu0.85191304
131MP0002092_abnormal_eye_morphology0.84921426
132MP0001286_abnormal_eye_development0.84752201
133MP0004147_increased_porphyrin_level0.83776219
134MP0002064_seizures0.83600576
135MP0003631_nervous_system_phenotype0.82090479
136MP0002066_abnormal_motor_capabilities/c0.81800661
137MP0001346_abnormal_lacrimal_gland0.81624302
138MP0002653_abnormal_ependyma_morphology0.81371653
139MP0000689_abnormal_spleen_morphology0.81154546
140MP0002210_abnormal_sex_determination0.81071034
141MP0000579_abnormal_nail_morphology0.80702641
142MP0001188_hyperpigmentation0.79987553
143MP0009053_abnormal_anal_canal0.78528270
144MP0002095_abnormal_skin_pigmentation0.78353367
145MP0001119_abnormal_female_reproductive0.77735190
146MP0002111_abnormal_tail_morphology0.77012170
147MP0003123_paternal_imprinting0.75974357
148MP0002398_abnormal_bone_marrow0.75938802
149MP0002877_abnormal_melanocyte_morpholog0.74211850
150MP0009672_abnormal_birth_weight0.73210195
151MP0009780_abnormal_chondrocyte_physiolo0.72242781
152MP0003943_abnormal_hepatobiliary_system0.72224795
153MP0002722_abnormal_immune_system0.71955960
154MP0005464_abnormal_platelet_physiology0.71745295
155MP0002396_abnormal_hematopoietic_system0.71734085
156MP0002160_abnormal_reproductive_system0.66201569
157MP0001727_abnormal_embryo_implantation0.64732923
158MP0003699_abnormal_female_reproductive0.63078673
159MP0000377_abnormal_hair_follicle0.62651496
160MP0005187_abnormal_penis_morphology0.62201780
161MP0003300_gastrointestinal_ulcer0.60912982
162MP0005671_abnormal_response_to0.60600712
163MP0006276_abnormal_autonomic_nervous0.60264791
164MP0003656_abnormal_erythrocyte_physiolo0.59806546
165MP0003567_abnormal_fetal_cardiomyocyte0.58861214
166MP0005384_cellular_phenotype0.56630247

Predicted human phenotypes

RankGene SetZ-score
1Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)5.68757481
2Degeneration of the lateral corticospinal tracts (HP:0002314)5.68757481
3Abnormality of the corticospinal tract (HP:0002492)4.38177733
4Alacrima (HP:0000522)4.35208543
5Parakeratosis (HP:0001036)3.83875948
6Increased nuchal translucency (HP:0010880)3.64721814
7Sensory axonal neuropathy (HP:0003390)3.63929098
8Cerebral hypomyelination (HP:0006808)3.60096283
9Decreased lacrimation (HP:0000633)3.58382360
10Neurofibrillary tangles (HP:0002185)3.56896123
11Proximal placement of thumb (HP:0009623)3.42316719
12Abnormality of the labia minora (HP:0012880)3.42123413
13Chromsome breakage (HP:0040012)3.37536789
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.32151444
15Chronic bronchitis (HP:0004469)3.18418431
16Peripheral hypomyelination (HP:0007182)3.18023693
17Hypoplastic pelvis (HP:0008839)3.07346028
18Spastic gait (HP:0002064)2.96243593
19Facial hemangioma (HP:0000329)2.94808504
20Termporal pattern (HP:0011008)2.93119494
21Insidious onset (HP:0003587)2.93119494
22Deviation of the thumb (HP:0009603)2.91496292
23Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.89891470
24Cortical dysplasia (HP:0002539)2.85788833
25Medulloblastoma (HP:0002885)2.84671235
26Absent septum pellucidum (HP:0001331)2.82290467
27Cerebral inclusion bodies (HP:0100314)2.82016020
28Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.79227479
29Esophageal atresia (HP:0002032)2.78377631
30Truncal obesity (HP:0001956)2.73012581
31Myelodysplasia (HP:0002863)2.72725327
32Onion bulb formation (HP:0003383)2.69042025
33Aplastic anemia (HP:0001915)2.68727316
34Abnormality of the septum pellucidum (HP:0007375)2.61570412
35Microvesicular hepatic steatosis (HP:0001414)2.59788079
36Papillary thyroid carcinoma (HP:0002895)2.59738865
37Dry hair (HP:0011359)2.57988815
38Abnormality of chromosome stability (HP:0003220)2.57352957
39Rhabdomyosarcoma (HP:0002859)2.57224521
40Akinesia (HP:0002304)2.56617963
41Septo-optic dysplasia (HP:0100842)2.52602215
42Partial agenesis of the corpus callosum (HP:0001338)2.49671128
43Autoamputation (HP:0001218)2.45784758
44Abnormal auditory evoked potentials (HP:0006958)2.44175784
45Chin dimple (HP:0010751)2.43946941
46Adrenal hypoplasia (HP:0000835)2.43397737
47Retinal dysplasia (HP:0007973)2.41462686
48Duplicated collecting system (HP:0000081)2.41403123
49Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.38920170
50Short 1st metacarpal (HP:0010034)2.38920170
51Low anterior hairline (HP:0000294)2.35671542
52Blepharitis (HP:0000498)2.35215019
53Cupped ear (HP:0000378)2.33038356
54Morphological abnormality of the inner ear (HP:0011390)2.32292655
55Thyroid carcinoma (HP:0002890)2.31178949
56Aplasia/Hypoplasia of the uvula (HP:0010293)2.30898083
57Cutaneous melanoma (HP:0012056)2.30879878
58Myelomeningocele (HP:0002475)2.29231603
59Abnormality of the preputium (HP:0100587)2.27129960
60Premature skin wrinkling (HP:0100678)2.25178163
61Overlapping toe (HP:0001845)2.24957087
62Anteriorly placed anus (HP:0001545)2.22833930
63Squamous cell carcinoma (HP:0002860)2.21481273
64Rib fusion (HP:0000902)2.20387497
65Supranuclear gaze palsy (HP:0000605)2.19346451
66Asplenia (HP:0001746)2.16550675
67Prominent occiput (HP:0000269)2.14072941
68Sloping forehead (HP:0000340)2.11886556
69CNS hypomyelination (HP:0003429)2.11819073
70Abnormality of methionine metabolism (HP:0010901)2.09878857
71Nephroblastoma (Wilms tumor) (HP:0002667)2.08494948
72Degeneration of anterior horn cells (HP:0002398)2.08424545
73Abnormality of the anterior horn cell (HP:0006802)2.08424545
74Pancytopenia (HP:0001876)2.08049268
75Ectopic kidney (HP:0000086)2.07837931
76Aplasia/Hypoplasia of the spleen (HP:0010451)2.07753052
77Hypoplasia of the iris (HP:0007676)2.06339438
78Abnormality of the renal collecting system (HP:0004742)2.06293387
79Gastrointestinal atresia (HP:0002589)2.05283182
80Abnormality of the 1st metacarpal (HP:0010009)2.04446278
81Small intestinal stenosis (HP:0012848)2.03024946
82Duodenal stenosis (HP:0100867)2.03024946
83Meckel diverticulum (HP:0002245)2.02683975
84IgG deficiency (HP:0004315)2.01653912
85Constricted visual fields (HP:0001133)1.95462016
86Ankle clonus (HP:0011448)1.95461462
87Embryonal renal neoplasm (HP:0011794)1.94423512
88Absent/shortened dynein arms (HP:0200106)1.94409186
89Dynein arm defect of respiratory motile cilia (HP:0012255)1.94409186
90Hypoplastic labia majora (HP:0000059)1.93649747
91Buphthalmos (HP:0000557)1.92887714
92Short middle phalanx of the 5th finger (HP:0004220)1.92804060
933-Methylglutaconic aciduria (HP:0003535)1.91586612
94Volvulus (HP:0002580)1.91544899
95Shoulder girdle muscle weakness (HP:0003547)1.91404422
96Aplasia/Hypoplasia of the earlobes (HP:0009906)1.90213906
97Shallow orbits (HP:0000586)1.88598546
98Scanning speech (HP:0002168)1.88235099
99Short middle phalanx of finger (HP:0005819)1.88121732
100Colon cancer (HP:0003003)1.87574564
101Facial cleft (HP:0002006)1.87290593
102Progressive inability to walk (HP:0002505)1.86324859
103Lissencephaly (HP:0001339)1.86221223
104Poor speech (HP:0002465)1.85174570
105Abnormality of the prostate (HP:0008775)1.84968470
106Intention tremor (HP:0002080)1.84828003
107Hyperglycinuria (HP:0003108)1.84562946
108Basal cell carcinoma (HP:0002671)1.83581091
109Overriding aorta (HP:0002623)1.83502704
110Large earlobe (HP:0009748)1.83230431
111Thickened helices (HP:0000391)1.83168004
112Cystic hygroma (HP:0000476)1.83015384
113Progressive external ophthalmoplegia (HP:0000590)1.81399168
114Cafe-au-lait spot (HP:0000957)1.81281889
115Abnormality of the phalanges of the hallux (HP:0010057)1.80181590
116Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.79381279
117Short 4th metacarpal (HP:0010044)1.79381279
118Abnormality of the ileum (HP:0001549)1.78950568
119Vertebral arch anomaly (HP:0008438)1.78870900
120Segmental peripheral demyelination/remyelination (HP:0003481)1.78533664
121Congenital ichthyosiform erythroderma (HP:0007431)1.78046597
122Gastroesophageal reflux (HP:0002020)1.77598131
123Intrahepatic cholestasis (HP:0001406)1.77418024
124Relative macrocephaly (HP:0004482)1.76831126
125Long nose (HP:0003189)1.76345236
126Abnormality of the distal phalanx of the thumb (HP:0009617)1.76217257
127Coronal craniosynostosis (HP:0004440)1.75665799
128Abnormality of the labia majora (HP:0012881)1.75464803
129Deep philtrum (HP:0002002)1.75278253
130Abnormality of the fingertips (HP:0001211)1.75258732
131Redundant skin (HP:0001582)1.75197283
132Aplasia/Hypoplasia of the nipples (HP:0006709)1.74886188
133Acute myeloid leukemia (HP:0004808)1.74154736
134Radioulnar synostosis (HP:0002974)1.73470785
135Cutis marmorata (HP:0000965)1.73094122
136Median cleft lip (HP:0000161)1.72581806
137Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72359815
138Type I transferrin isoform profile (HP:0003642)1.72355180
139Neoplasm of striated muscle (HP:0009728)1.71864596
140Abnormality of glycolysis (HP:0004366)1.71784577
141Increased serum pyruvate (HP:0003542)1.71784577
142Abnormality of the duodenum (HP:0002246)1.71028169
143Abnormal lung lobation (HP:0002101)1.70927826
144Neoplasm of the colon (HP:0100273)1.68876282
145Abolished electroretinogram (ERG) (HP:0000550)1.68457287
146Broad ribs (HP:0000885)1.64765433
147Postnatal growth retardation (HP:0008897)1.64042409
148Dysmetria (HP:0001310)1.62882035
149Abnormal umbilical cord blood vessels (HP:0011403)1.62547767
150Single umbilical artery (HP:0001195)1.62547767
151Abnormality of the fetal cardiovascular system (HP:0010948)1.62547767
152Pelvic girdle muscle weakness (HP:0003749)1.62410586
153Keratoconus (HP:0000563)1.62148601
154Increased corneal curvature (HP:0100692)1.62148601
155Intellectual disability, moderate (HP:0002342)1.61759784
156Cerebral edema (HP:0002181)1.61157433
157Abnormality of glycine metabolism (HP:0010895)1.61138104
158Abnormality of serine family amino acid metabolism (HP:0010894)1.61138104
159Absent radius (HP:0003974)1.60609084
160Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.60472343
161Anomalous pulmonary venous return (HP:0010772)1.60466229
162Neoplasm of the tracheobronchial system (HP:0100552)1.60279106
163Bell-shaped thorax (HP:0001591)1.59808619
164Decreased motor nerve conduction velocity (HP:0003431)1.59550444
165Abnormality of the diencephalon (HP:0010662)1.59388336
166Long clavicles (HP:0000890)1.59142091
167Urinary urgency (HP:0000012)1.59130810
168Absent forearm bone (HP:0003953)1.58575425
169Aplasia involving forearm bones (HP:0009822)1.58575425
170Abnormality of cochlea (HP:0000375)1.58279144
171Postaxial foot polydactyly (HP:0001830)1.57583092
172Abnormality of alanine metabolism (HP:0010916)1.57396631
173Hyperalaninemia (HP:0003348)1.57396631
174Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57396631
175Low posterior hairline (HP:0002162)1.56956471
176White forelock (HP:0002211)1.56845482
177Meningocele (HP:0002435)1.55802667
178Micropenis (HP:0000054)1.54678025
179Hypoplasia of the pons (HP:0012110)1.54364469
180Septate vagina (HP:0001153)1.53806371
181Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.53730729
182Choanal atresia (HP:0000453)1.52656065
183Patchy hypopigmentation of hair (HP:0011365)1.52011693
184Confusion (HP:0001289)1.51785614
185Radial bowing (HP:0002986)1.51658659
186Lower limb muscle weakness (HP:0007340)1.51130723
187Morphological abnormality of the pyramidal tract (HP:0002062)1.51123292
188Stridor (HP:0010307)1.49856590
189Genital tract atresia (HP:0001827)1.49401898
190Vaginal atresia (HP:0000148)1.48910027

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K97.14242178
2STK395.03390846
3TAF14.69867266
4OXSR13.40450873
5EIF2AK13.34664498
6PNCK3.27148129
7ICK2.58724485
8EPHB12.53092699
9TRIM282.39000911
10EIF2AK32.37895778
11CSNK1G32.32381624
12BRSK22.28370696
13PKN12.24927457
14CSNK1A1L2.23216182
15LIMK12.10956099
16MET2.10872377
17PRPF4B2.09342485
18MARK12.08293120
19UHMK12.08088310
20BCR1.98224537
21NEK11.95802660
22PBK1.87449289
23VRK21.87153135
24MKNK11.86830968
25MAPKAPK51.86744022
26CASK1.83566594
27PIK3CG1.82837708
28FGFR21.80651196
29STK38L1.78672287
30CSNK1G11.73704612
31WNK11.67835518
32BRD41.66367319
33WNK41.63286241
34CSNK1G21.62386838
35TESK21.56248078
36CLK11.50482620
37TNIK1.45014966
38NEK61.43340040
39DYRK21.41017570
40TAOK31.39384445
41WEE11.33957523
42MAP3K121.33171330
43ROCK21.28423143
44TYRO31.23268434
45MKNK21.19422859
46CDK121.19012136
47WNK31.17694759
48ERBB31.17511916
49AURKB1.14739503
50FGR1.12664864
51STK101.10844275
52CDK191.10707346
53PLK11.09326964
54CAMK2B1.08929633
55MAPK131.02881772
56DYRK31.02689920
57TEC0.99277190
58MARK20.94887195
59PAK60.94578396
60CDC70.93759445
61VRK10.91233370
62BRSK10.89456130
63PAK30.86006528
64CDK90.85094000
65CSNK1D0.84095520
66MAP3K40.82392842
67SRPK10.80751019
68SMG10.79640812
69TTK0.79330443
70TSSK60.78781201
71RPS6KA50.78339044
72STK30.75601975
73BUB10.73952875
74NTRK10.73512678
75MAP4K20.73343630
76MAP2K20.73329288
77CAMK1G0.72536036
78CDK140.72445813
79EPHA20.71478888
80LATS10.70510546
81SCYL20.70067947
82RPS6KB20.69707464
83CDK150.68825077
84SGK2230.68065547
85SGK4940.68065547
86* CSNK2A20.66157695
87BRAF0.66122118
88TLK10.65900694
89EIF2AK20.63337030
90CDK11A0.62980242
91AKT30.62853649
92KSR10.61400844
93CSNK1E0.61228951
94CDK180.60525689
95MARK30.58264750
96ITK0.57470625
97* CHEK10.56885737
98PASK0.56121686
99PAK10.56093314
100CAMK2D0.55771118
101CDK50.55676953
102* CDK10.55272113
103NEK90.54359877
104PLK40.53574801
105RAF10.52555104
106MST40.52077130
107CDK70.51817590
108MAP3K80.51218435
109MELK0.50254321
110MAP3K140.50072417
111RPS6KA40.49683106
112PDGFRB0.49231182
113ALK0.48742262
114ATM0.47280945
115PLK30.46599473
116GSK3A0.46424003
117PAK20.45283186
118BLK0.44798141
119PLK20.44332483
120NEK20.44247287
121NUAK10.43305608
122* GSK3B0.43029469
123MAP3K100.41941987
124CDK20.41894928
125ATR0.41135837
126PRKDC0.40798061
127FGFR10.39964447
128DDR20.39891258
129TRPM70.39502866
130CDK40.39421774
131MTOR0.38709837
132BMPR1B0.38313644
133PRKCQ0.37995000
134CCNB10.37790802
135CHEK20.37542921
136CSNK2A10.37092337
137DYRK1A0.36697084
138BMPR20.36646162
139MAPK100.36598538
140SIK30.35699775
141KSR20.34413217
142* PRKACB0.34202721
143ERBB40.33793115
144FYN0.31809128
145AURKA0.30958656
146PRKD10.30670386
147MAPK90.30501072
148BTK0.30420500
149* MAPK140.30053390
150CAMKK20.29102498
151YES10.28943652
152NTRK20.28837232
153MATK0.27495362
154PDK20.27267291
155NLK0.26553171
156STK240.25235604
157STK40.22778116
158FGFR30.20677475

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009005.43069922
2Steroid biosynthesis_Homo sapiens_hsa001004.23433207
3Fatty acid elongation_Homo sapiens_hsa000623.50571116
4One carbon pool by folate_Homo sapiens_hsa006702.94299681
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.89204254
6Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.72529155
7Ether lipid metabolism_Homo sapiens_hsa005652.71782416
8Base excision repair_Homo sapiens_hsa034102.35196344
9Axon guidance_Homo sapiens_hsa043602.33356442
10Propanoate metabolism_Homo sapiens_hsa006402.12757314
11Non-homologous end-joining_Homo sapiens_hsa034501.98435117
12Basal transcription factors_Homo sapiens_hsa030221.88857382
13Hedgehog signaling pathway_Homo sapiens_hsa043401.75941432
14Phototransduction_Homo sapiens_hsa047441.74254084
15Spliceosome_Homo sapiens_hsa030401.74121249
16Cysteine and methionine metabolism_Homo sapiens_hsa002701.70370109
17Pyruvate metabolism_Homo sapiens_hsa006201.66355238
18Protein export_Homo sapiens_hsa030601.56489140
19Basal cell carcinoma_Homo sapiens_hsa052171.54320863
20Pyrimidine metabolism_Homo sapiens_hsa002401.51236294
21Ribosome_Homo sapiens_hsa030101.46579679
22Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.45657994
23Tight junction_Homo sapiens_hsa045301.45126260
24Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.41387582
25Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.37859968
26RNA polymerase_Homo sapiens_hsa030201.37410866
27Fanconi anemia pathway_Homo sapiens_hsa034601.34616627
28Sphingolipid metabolism_Homo sapiens_hsa006001.32533800
29mRNA surveillance pathway_Homo sapiens_hsa030151.29142677
30Alcoholism_Homo sapiens_hsa050341.28329788
31Renal cell carcinoma_Homo sapiens_hsa052111.27523180
32Linoleic acid metabolism_Homo sapiens_hsa005911.25045991
33Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.22113896
34Nucleotide excision repair_Homo sapiens_hsa034201.20635827
35Cell cycle_Homo sapiens_hsa041101.19431310
36Systemic lupus erythematosus_Homo sapiens_hsa053221.18935825
37Homologous recombination_Homo sapiens_hsa034401.18916070
38p53 signaling pathway_Homo sapiens_hsa041151.18380097
39Hippo signaling pathway_Homo sapiens_hsa043901.09747295
40Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.09543308
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.09427463
42RNA transport_Homo sapiens_hsa030131.04359763
43Epstein-Barr virus infection_Homo sapiens_hsa051691.04231808
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.04003731
45Maturity onset diabetes of the young_Homo sapiens_hsa049501.03352850
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03121954
47Vitamin B6 metabolism_Homo sapiens_hsa007501.01336925
48Serotonergic synapse_Homo sapiens_hsa047260.99468161
49Wnt signaling pathway_Homo sapiens_hsa043100.98846948
50Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98425860
51ECM-receptor interaction_Homo sapiens_hsa045120.92299943
52Purine metabolism_Homo sapiens_hsa002300.90828844
53Huntingtons disease_Homo sapiens_hsa050160.89772462
54Caffeine metabolism_Homo sapiens_hsa002320.89110538
55Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.88600526
56Mismatch repair_Homo sapiens_hsa034300.87329766
57Selenocompound metabolism_Homo sapiens_hsa004500.86112951
58Ras signaling pathway_Homo sapiens_hsa040140.81970838
59Parkinsons disease_Homo sapiens_hsa050120.81729571
60Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.81359621
61Primary immunodeficiency_Homo sapiens_hsa053400.79829429
62RNA degradation_Homo sapiens_hsa030180.79798218
63Phospholipase D signaling pathway_Homo sapiens_hsa040720.77760087
64DNA replication_Homo sapiens_hsa030300.76732939
65Long-term depression_Homo sapiens_hsa047300.76720151
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76360222
67MicroRNAs in cancer_Homo sapiens_hsa052060.75940505
68Herpes simplex infection_Homo sapiens_hsa051680.74075006
69Thyroid cancer_Homo sapiens_hsa052160.73922055
70Endocytosis_Homo sapiens_hsa041440.71539845
71Glutamatergic synapse_Homo sapiens_hsa047240.71443502
72Sulfur metabolism_Homo sapiens_hsa009200.70158363
73ErbB signaling pathway_Homo sapiens_hsa040120.69612132
74PI3K-Akt signaling pathway_Homo sapiens_hsa041510.69510431
75Colorectal cancer_Homo sapiens_hsa052100.68941349
76Measles_Homo sapiens_hsa051620.68010590
77Sphingolipid signaling pathway_Homo sapiens_hsa040710.67446973
78Prostate cancer_Homo sapiens_hsa052150.66748228
79Choline metabolism in cancer_Homo sapiens_hsa052310.66739956
80Viral carcinogenesis_Homo sapiens_hsa052030.65867946
81Ovarian steroidogenesis_Homo sapiens_hsa049130.65815224
82Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.64419825
83Pathways in cancer_Homo sapiens_hsa052000.64083736
84Gap junction_Homo sapiens_hsa045400.61022485
85Tryptophan metabolism_Homo sapiens_hsa003800.59915906
86Oocyte meiosis_Homo sapiens_hsa041140.59866441
87Notch signaling pathway_Homo sapiens_hsa043300.59103171
88Regulation of actin cytoskeleton_Homo sapiens_hsa048100.57476052
89Vibrio cholerae infection_Homo sapiens_hsa051100.56845131
90Cocaine addiction_Homo sapiens_hsa050300.56642166
91Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56597549
92Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.55464115
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54238256
94Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.53207657
95Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53120463
96Viral myocarditis_Homo sapiens_hsa054160.52421447
97Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.52030550
98Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.51378480
99Sulfur relay system_Homo sapiens_hsa041220.50675609
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.50466795
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.49444934
102Dorso-ventral axis formation_Homo sapiens_hsa043200.49384643
103Dopaminergic synapse_Homo sapiens_hsa047280.49326519
104Regulation of autophagy_Homo sapiens_hsa041400.48426812
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48182573
106TGF-beta signaling pathway_Homo sapiens_hsa043500.47888416
107Melanogenesis_Homo sapiens_hsa049160.45601528
108Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45434000
109Arginine and proline metabolism_Homo sapiens_hsa003300.43903749
1102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.43872954
111GABAergic synapse_Homo sapiens_hsa047270.43777201
112Antigen processing and presentation_Homo sapiens_hsa046120.43381074
113Focal adhesion_Homo sapiens_hsa045100.42472424
114Arachidonic acid metabolism_Homo sapiens_hsa005900.41201464
115Vascular smooth muscle contraction_Homo sapiens_hsa042700.41105633
116beta-Alanine metabolism_Homo sapiens_hsa004100.40997674
117Butanoate metabolism_Homo sapiens_hsa006500.40274396
118Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.38938777
119MAPK signaling pathway_Homo sapiens_hsa040100.38834641
120Histidine metabolism_Homo sapiens_hsa003400.38700765
121Circadian rhythm_Homo sapiens_hsa047100.37085343
122Cholinergic synapse_Homo sapiens_hsa047250.36860899
123Morphine addiction_Homo sapiens_hsa050320.36665512
124Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35395830
125Glutathione metabolism_Homo sapiens_hsa004800.35219095
126Transcriptional misregulation in cancer_Homo sapiens_hsa052020.34941921
127Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.34937978
128Carbon metabolism_Homo sapiens_hsa012000.34647028
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.33528570
130Proteasome_Homo sapiens_hsa030500.32582644
131Biosynthesis of amino acids_Homo sapiens_hsa012300.32240943
132Lysine degradation_Homo sapiens_hsa003100.32193438
133Melanoma_Homo sapiens_hsa052180.31872405
134Pancreatic cancer_Homo sapiens_hsa052120.31823705
135Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.31801349
136Shigellosis_Homo sapiens_hsa051310.31652177
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.30878992
138Oxidative phosphorylation_Homo sapiens_hsa001900.30790816
139Inositol phosphate metabolism_Homo sapiens_hsa005620.29889043
140N-Glycan biosynthesis_Homo sapiens_hsa005100.29093899
141Fatty acid degradation_Homo sapiens_hsa000710.28735576
142Metabolic pathways_Homo sapiens_hsa011000.27770938
143Fatty acid metabolism_Homo sapiens_hsa012120.27692283
144Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.27369565
145Drug metabolism - other enzymes_Homo sapiens_hsa009830.27195811
146Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.24898001
147Fatty acid biosynthesis_Homo sapiens_hsa000610.22882481
148RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.21326299
149T cell receptor signaling pathway_Homo sapiens_hsa046600.18275075
150Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17915016
151Retinol metabolism_Homo sapiens_hsa008300.17910095
152B cell receptor signaling pathway_Homo sapiens_hsa046620.17022358
153Alzheimers disease_Homo sapiens_hsa050100.16385126
154Hepatitis B_Homo sapiens_hsa051610.15505757
155Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.15063990
156Apoptosis_Homo sapiens_hsa042100.14544204
157Legionellosis_Homo sapiens_hsa051340.13586317
158HTLV-I infection_Homo sapiens_hsa051660.13427078
159Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.12630635
160Adherens junction_Homo sapiens_hsa045200.12426859

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »