CTRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the serine protease family of enzymes and forms a principal precursor of the pancreatic proteolytic enzymes. The encoded preproprotein is synthesized in the acinar cells of the pancreas and secreted into the small intestine where it undergoes proteolytic activation to generate a functional enzyme. This gene is located adjacent to a related chymotrypsinogen gene. This gene encodes distinct isoforms, some or all of which may undergo similar processing to generate the mature protein. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of epidermis development (GO:0045683)8.02454447
2COPI coating of Golgi vesicle (GO:0048205)7.36941043
3Golgi transport vesicle coating (GO:0048200)7.36941043
4neutrophil mediated immunity (GO:0002446)7.09728691
5polyketide metabolic process (GO:0030638)7.08659943
6doxorubicin metabolic process (GO:0044598)7.08659943
7daunorubicin metabolic process (GO:0044597)7.08659943
8intestinal absorption (GO:0050892)6.89569545
9sterol catabolic process (GO:0016127)6.84997430
10cholesterol catabolic process (GO:0006707)6.84997430
11phosphatidylinositol acyl-chain remodeling (GO:0036149)6.52324151
12phosphatidylserine acyl-chain remodeling (GO:0036150)6.39612369
13aminoglycoside antibiotic metabolic process (GO:0030647)6.32898119
14arachidonic acid secretion (GO:0050482)6.32718455
15icosanoid secretion (GO:0032309)6.32718455
16phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.28131517
17* cobalamin metabolic process (GO:0009235)6.19980846
18transcytosis (GO:0045056)6.18401927
19peptidyl-proline hydroxylation (GO:0019511)6.12227055
20endocrine pancreas development (GO:0031018)5.95800784
21intestinal epithelial cell development (GO:0060576)5.88986820
22regulation of keratinocyte differentiation (GO:0045616)5.82761115
23activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.78392151
24positive regulation of nuclease activity (GO:0032075)5.56484597
25regulation of keratinocyte proliferation (GO:0010837)5.45500125
26* tetrapyrrole metabolic process (GO:0033013)5.33212639
27fatty acid derivative transport (GO:1901571)5.28581688
28icosanoid transport (GO:0071715)5.28581688
29myeloid leukocyte mediated immunity (GO:0002444)5.05882507
30cysteine metabolic process (GO:0006534)5.04842323
31regulation of nuclease activity (GO:0032069)5.04414341
32endoplasmic reticulum unfolded protein response (GO:0030968)5.01640182
33protein hydroxylation (GO:0018126)5.00659011
34proline biosynthetic process (GO:0006561)4.98985024
35innate immune response in mucosa (GO:0002227)4.86295203
36regulation of acrosome reaction (GO:0060046)4.85020041
37cellular response to unfolded protein (GO:0034620)4.83466787
38cellular protein catabolic process (GO:0044257)4.79261059
39acute-phase response (GO:0006953)4.74094127
40negative regulation of digestive system process (GO:0060457)4.74066238
41response to endoplasmic reticulum stress (GO:0034976)4.71841803
42membrane lipid catabolic process (GO:0046466)4.65933831
43ER-nucleus signaling pathway (GO:0006984)4.64996105
44phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.62680284
45polarized epithelial cell differentiation (GO:0030859)4.57669275
46ceramide catabolic process (GO:0046514)4.57127746
47cellular response to topologically incorrect protein (GO:0035967)4.56629542
48protein maturation by protein folding (GO:0022417)4.40343111
49phosphatidylserine metabolic process (GO:0006658)4.32692230
50regulation of phospholipase A2 activity (GO:0032429)4.31470043
51digestive system process (GO:0022600)4.23434519
52leukotriene metabolic process (GO:0006691)4.20759057
53calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)4.20558474
54glycolipid catabolic process (GO:0019377)4.20371978
55COPII vesicle coating (GO:0048208)4.17415537
56retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.14308461
57* water-soluble vitamin metabolic process (GO:0006767)4.09962769
58phospholipid catabolic process (GO:0009395)3.98510560
59mucosal immune response (GO:0002385)3.97680782
60pancreas development (GO:0031016)3.97643150
61maintenance of gastrointestinal epithelium (GO:0030277)3.95523102
62phosphatidylcholine acyl-chain remodeling (GO:0036151)3.93912875
63response to unfolded protein (GO:0006986)3.90212720
64sterol transport (GO:0015918)3.86301231
65mitochondrial calcium ion transport (GO:0006851)3.86078739
66serine family amino acid biosynthetic process (GO:0009070)3.82303642
674-hydroxyproline metabolic process (GO:0019471)3.81156756
68maintenance of protein localization in organelle (GO:0072595)3.76267516
69antibacterial humoral response (GO:0019731)3.75466743
70homocysteine metabolic process (GO:0050667)3.74965707
71cellular modified amino acid catabolic process (GO:0042219)3.74526544
72response to topologically incorrect protein (GO:0035966)3.73981145
73zinc ion transport (GO:0006829)3.70153525
74valine metabolic process (GO:0006573)3.70040615
75establishment of apical/basal cell polarity (GO:0035089)3.69642272
76phosphatidic acid biosynthetic process (GO:0006654)3.66143885
77phosphatidic acid metabolic process (GO:0046473)3.66143885
78insulin-like growth factor receptor signaling pathway (GO:0048009)3.63090776
79glutathione derivative metabolic process (GO:1901685)3.62984515
80glutathione derivative biosynthetic process (GO:1901687)3.62984515
81organ or tissue specific immune response (GO:0002251)3.58456051
82ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.57040982
83alditol phosphate metabolic process (GO:0052646)3.56208523
84branched-chain amino acid catabolic process (GO:0009083)3.55033567
85regulation of epidermal cell differentiation (GO:0045604)3.54001604
86aspartate family amino acid catabolic process (GO:0009068)3.53947925
87peptidyl-asparagine modification (GO:0018196)3.49997325
88protein N-linked glycosylation via asparagine (GO:0018279)3.49979700
89ER overload response (GO:0006983)3.49861596
90progesterone metabolic process (GO:0042448)3.47396709
91defense response to Gram-positive bacterium (GO:0050830)3.47145782
92regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.46032035
93antimicrobial humoral response (GO:0019730)3.45953732
94L-serine metabolic process (GO:0006563)3.44677253
95regulation of metalloenzyme activity (GO:0048552)3.43390814
96regulation of triglyceride catabolic process (GO:0010896)3.40673053
97positive regulation of wound healing (GO:0090303)3.35507772
98glutamine metabolic process (GO:0006541)3.34124923
99glycoside metabolic process (GO:0016137)3.33530823
100steroid catabolic process (GO:0006706)3.31968064
101negative regulation of epithelial cell differentiation (GO:0030857)3.31902251
102regulation of hormone metabolic process (GO:0032350)3.30571078
103acute inflammatory response (GO:0002526)3.30092715
104L-alpha-amino acid transmembrane transport (GO:1902475)3.26715818
105primary alcohol catabolic process (GO:0034310)3.25063884
106retinoid metabolic process (GO:0001523)3.24397158
107peptide catabolic process (GO:0043171)3.23747505
108signal peptide processing (GO:0006465)3.23091815
109columnar/cuboidal epithelial cell development (GO:0002066)3.22267103
110* vitamin metabolic process (GO:0006766)3.21725214
111branched-chain amino acid metabolic process (GO:0009081)3.20752653
112icosanoid biosynthetic process (GO:0046456)3.18692636
113fatty acid derivative biosynthetic process (GO:1901570)3.18692636
114positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.18087626
115protein N-linked glycosylation (GO:0006487)3.17731946
116establishment or maintenance of monopolar cell polarity (GO:0061339)3.14255438
117establishment of monopolar cell polarity (GO:0061162)3.14255438
118regulation of cholesterol homeostasis (GO:2000188)3.13345944
119vesicle coating (GO:0006901)3.12765454
120proline metabolic process (GO:0006560)3.11841113
121Golgi organization (GO:0007030)3.11743068
122retinoic acid receptor signaling pathway (GO:0048384)3.06488792
123diterpenoid metabolic process (GO:0016101)3.05259244
124membrane repolarization during cardiac muscle cell action potential (GO:0086013)3.04484718
125nucleotide-sugar biosynthetic process (GO:0009226)3.03787058
126regulation of calcium ion import (GO:0090279)3.02485779
127negative regulation of hormone metabolic process (GO:0032351)2.99066473
128phototransduction, visible light (GO:0007603)2.95855655
129endothelial cell migration (GO:0043542)2.95760485
130macroautophagy (GO:0016236)2.94922768
131glandular epithelial cell differentiation (GO:0002067)2.93403574
132multicellular organismal metabolic process (GO:0044236)2.88287189
133peroxisome fission (GO:0016559)2.85219164
134phosphatidylglycerol metabolic process (GO:0046471)2.85036709
135atrioventricular valve morphogenesis (GO:0003181)2.82295209
136lung secretory cell differentiation (GO:0061140)2.81775199
137mitochondrion distribution (GO:0048311)2.79852980
138* extracellular matrix disassembly (GO:0022617)2.79183317
139positive regulation of heat generation (GO:0031652)2.79090158
140negative regulation of mRNA metabolic process (GO:1903312)2.78970029
141serine family amino acid metabolic process (GO:0009069)2.77732197
142creatine metabolic process (GO:0006600)2.77592481
143negative regulation of Notch signaling pathway (GO:0045746)2.75616318
144regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.72263750
145leukotriene biosynthetic process (GO:0019370)2.72258435
146cell redox homeostasis (GO:0045454)2.71794326
147sphingolipid catabolic process (GO:0030149)2.70861747
148water-soluble vitamin biosynthetic process (GO:0042364)2.70624580
149retinal metabolic process (GO:0042574)2.70529230
150epithelial structure maintenance (GO:0010669)2.70514230
151cellular response to cadmium ion (GO:0071276)2.69707958
152membrane repolarization during action potential (GO:0086011)2.68317737
153terpenoid metabolic process (GO:0006721)2.67059156
154regulation of response to osmotic stress (GO:0047484)2.66629650
155L-phenylalanine catabolic process (GO:0006559)2.65616731
156erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65616731
157negative regulation of cell fate commitment (GO:0010454)2.63292151
158type B pancreatic cell development (GO:0003323)2.58469947
159regulation of fever generation (GO:0031620)2.57540469
160nephron tubule morphogenesis (GO:0072078)2.56701279
161nephron epithelium morphogenesis (GO:0072088)2.56701279
162embryonic foregut morphogenesis (GO:0048617)2.56339559
163multicellular organismal catabolic process (GO:0044243)2.54734735
164L-phenylalanine metabolic process (GO:0006558)2.54310383
165erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.54310383
166regulation of oxidative stress-induced cell death (GO:1903201)2.53305743
167positive regulation of glycogen biosynthetic process (GO:0045725)2.51061571
168protein targeting to ER (GO:0045047)2.50820483
169cholesterol transport (GO:0030301)2.50748262
170exocrine pancreas development (GO:0031017)18.0339608
171intestinal cholesterol absorption (GO:0030299)15.2015644
172* digestion (GO:0007586)11.7578131
173protein retention in ER lumen (GO:0006621)11.1044053
174maintenance of protein localization in endoplasmic reticulum (GO:0035437)10.7285393
175negative regulation of epidermal cell differentiation (GO:0045605)10.5829854

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.72314382
2STAT6_21828071_ChIP-Seq_BEAS2B_Human4.66311154
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.96012305
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.34168895
5SOX2_27498859_Chip-Seq_STOMACH_Mouse2.69319939
6ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.68516890
7GATA1_22025678_ChIP-Seq_K562_Human2.68228839
8ERG_21242973_ChIP-ChIP_JURKAT_Human2.68189764
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.63132023
10PPARA_22158963_ChIP-Seq_LIVER_Mouse2.40262644
11RARG_19884340_ChIP-ChIP_MEFs_Mouse2.35911934
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.29465734
13CLOCK_20551151_ChIP-Seq_293T_Human2.20330611
14GATA6_25053715_ChIP-Seq_YYC3_Human2.16834300
15* LXR_22158963_ChIP-Seq_LIVER_Mouse2.11059080
16PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.10881448
17GATA4_25053715_ChIP-Seq_YYC3_Human2.10059771
18FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.07328850
19HTT_18923047_ChIP-ChIP_STHdh_Human2.01731388
20TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.96969248
21ESR2_21235772_ChIP-Seq_MCF-7_Human1.96019648
22LXR_22292898_ChIP-Seq_THP-1_Human1.93223702
23ESR1_21235772_ChIP-Seq_MCF-7_Human1.85379683
24CREB1_26743006_Chip-Seq_LNCaP_Human1.78732240
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.77423120
26TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74832660
27RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.73449373
28TCF4_18268006_ChIP-ChIP_LS174T_Human1.66708332
29CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.65227515
30CHD1_26751641_Chip-Seq_LNCaP_Human1.64545056
31RACK7_27058665_Chip-Seq_MCF-7_Human1.63178498
32MYC_22102868_ChIP-Seq_BL_Human1.61699567
33E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.60907259
34CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.59751594
35DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.56421210
36FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.52468647
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.48145562
38RUNX1_27514584_Chip-Seq_MCF-7_Human1.47561350
39P68_20966046_ChIP-Seq_HELA_Human1.41129304
40PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40629770
41NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.39305919
42ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38015654
43ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37262921
44KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37001171
45ATF3_27146783_Chip-Seq_COLON_Human1.36883654
46KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.36690505
47SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.35469105
48TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.34717792
49TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.33907577
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.33309369
51FOXA1_25552417_ChIP-Seq_VCAP_Human1.33132515
52KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.32702167
53NFIB_24661679_ChIP-Seq_LUNG_Mouse1.31918391
54SA1_27219007_Chip-Seq_ERYTHROID_Human1.31549702
55JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30491983
56KDM2B_26808549_Chip-Seq_K562_Human1.30262535
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.29758086
58OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.29423296
59FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.27967752
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.26917497
61ETV1_20927104_ChIP-Seq_GIST48_Human1.26615178
62PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.26517043
63PHF8_20622853_ChIP-Seq_HELA_Human1.26161398
64ELK3_25401928_ChIP-Seq_HUVEC_Human1.25161063
65HNFA_21074721_ChIP-Seq_CACO-2_Human1.25107858
66FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.24679655
67JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24231073
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.24206339
69EGR1_19374776_ChIP-ChIP_THP-1_Human1.23891347
70CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.22488659
71NFYA_21822215_ChIP-Seq_K562_Human1.20241876
72GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.19741465
73ZNF217_24962896_ChIP-Seq_MCF-7_Human1.18282911
74TP63_22573176_ChIP-Seq_HFKS_Human1.18251024
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16903076
76DNAJC2_21179169_ChIP-ChIP_NT2_Human1.16586226
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15445017
78GATA6_21074721_ChIP-Seq_CACO-2_Human1.15224402
79CTCF_27219007_Chip-Seq_Bcells_Human1.15132158
80FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.14389801
81CDX2_20551321_ChIP-Seq_CACO-2_Human1.14204041
82SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.13517937
83RBPJ_21746931_ChIP-Seq_IB4_Human1.13300955
84HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.12693579
85TBX20_22328084_ChIP-Seq_HEART_Mouse1.11420775
86TBX20_22080862_ChIP-Seq_HEART_Mouse1.11420775
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.11148600
88EGR1_23403033_ChIP-Seq_LIVER_Mouse1.10636006
89DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.10578073
90CJUN_26792858_Chip-Seq_BT549_Human1.10559609
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.10081773
92KDM2B_26808549_Chip-Seq_DND41_Human1.09821045
93CBX2_22325352_ChIP-Seq_293T-Rex_Human1.08712807
94ESET_19884257_ChIP-Seq_ESCs_Mouse1.07777044
95FOXO3_23340844_ChIP-Seq_DLD1_Human1.07600867
96STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.06908283
97ZNF263_19887448_ChIP-Seq_K562_Human1.06621346
98RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.06211013
99RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05857339
100EGR1_19032775_ChIP-ChIP_M12_Human1.04327229
101NANOG_21062744_ChIP-ChIP_HESCs_Human1.04189525
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.03638238
103ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.03380040
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.03315131
105* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.02381490
106PPAR_26484153_Chip-Seq_NCI-H1993_Human1.01083953
107KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00479824
108NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.00311176
109SOX2_20726797_ChIP-Seq_SW620_Human0.99389622
110CDX2_19796622_ChIP-Seq_MESCs_Mouse0.99281969
111TP53_22127205_ChIP-Seq_IMR90_Human0.99031289
112EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.98049855
113AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97945813
114SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.96641718
115ERA_21632823_ChIP-Seq_H3396_Human0.95760175
116GATA1_19941826_ChIP-Seq_K562_Human0.95155197
117GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.94794667
118NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94783177
119NCOR1_26117541_ChIP-Seq_K562_Human0.94631307
120NFYB_21822215_ChIP-Seq_K562_Human0.94590845
121FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93030296
122ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92955015
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.92801977
124FOXP1_21924763_ChIP-Seq_HESCs_Human0.91200084
125FOXH1_21741376_ChIP-Seq_ESCs_Human0.90828994
126SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.89192414
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.88290367
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.88206122
129PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.88107449
130EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.87794315
131KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.87655077
132KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.87655077
133KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.87655077
134GATA1_26923725_Chip-Seq_HPCs_Mouse0.87639046
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87496110
136EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.87436461
137TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.87155668
138BCOR_27268052_Chip-Seq_Bcells_Human0.86773053
139CEBPB_22108803_ChIP-Seq_LS180_Human0.82121975
140FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.81122651
141FLI1_21867929_ChIP-Seq_CD8_Mouse0.80961478
142* TAF2_19829295_ChIP-Seq_ESCs_Human0.80939558
143SMAD4_21741376_ChIP-Seq_EPCs_Human0.79937813
144P300_27268052_Chip-Seq_Bcells_Human0.79090411
145FOXH1_21741376_ChIP-Seq_EPCs_Human0.79015332
146FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76570125
147AR_20517297_ChIP-Seq_VCAP_Human0.75693438
148SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75335372
149SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75335372
150CBP_21632823_ChIP-Seq_H3396_Human0.74946936
151TP53_18474530_ChIP-ChIP_U2OS_Human0.74432482
152CDX2_22108803_ChIP-Seq_LS180_Human0.73555754
153FOXA1_25329375_ChIP-Seq_VCAP_Human0.73443691
154FOXA1_27270436_Chip-Seq_PROSTATE_Human0.73443691
155ETV2_25802403_ChIP-Seq_MESCs_Mouse0.72250243
156P300_19829295_ChIP-Seq_ESCs_Human0.72045733
157HNF4A_19822575_ChIP-Seq_HepG2_Human0.70998613
158HIF1A_21447827_ChIP-Seq_MCF-7_Human0.69528069
159GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.69086232
160TBL1_22424771_ChIP-Seq_293T_Human0.66541344
161NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64704134
162NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64704134
163* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.62146588
164RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.60828489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract8.81190099
2MP0001666_abnormal_nutrient_absorption7.66013931
3MP0005220_abnormal_exocrine_pancreas6.31968297
4MP0003868_abnormal_feces_composition5.17791806
5MP0005084_abnormal_gallbladder_morpholo4.95561505
6MP0005365_abnormal_bile_salt4.94565327
7MP0003283_abnormal_digestive_organ3.15721137
8MP0003122_maternal_imprinting2.92449124
9MP0005085_abnormal_gallbladder_physiolo2.81818098
10MP0010386_abnormal_urinary_bladder2.69008268
11MP0002876_abnormal_thyroid_physiology2.68362380
12MP0002693_abnormal_pancreas_physiology2.65850052
13MP0003705_abnormal_hypodermis_morpholog2.65309797
14MP0002138_abnormal_hepatobiliary_system2.65165606
15MP0001944_abnormal_pancreas_morphology2.41929321
16MP0003959_abnormal_lean_body2.37160169
17MP0004264_abnormal_extraembryonic_tissu2.33614536
18MP0001664_abnormal_digestion2.20187808
19MP0010234_abnormal_vibrissa_follicle2.16213744
20MP0002139_abnormal_hepatobiliary_system1.97966504
21MP0003123_paternal_imprinting1.96389013
22MP0002928_abnormal_bile_duct1.94625929
23MP0006054_spinal_hemorrhage1.86972660
24MP0003011_delayed_dark_adaptation1.79254820
25MP0003252_abnormal_bile_duct1.78027314
26MP0008438_abnormal_cutaneous_collagen1.77048441
27MP0004233_abnormal_muscle_weight1.53213565
28MP0003195_calcinosis1.39038062
29MP0005448_abnormal_energy_balance1.21340013
30MP0004272_abnormal_basement_membrane1.16629671
31MP0003638_abnormal_response/metabolism_1.15178396
32MP0000003_abnormal_adipose_tissue1.09394311
33MP0002132_abnormal_respiratory_system1.06979779
34MP0001756_abnormal_urination1.04079655
35MP0008961_abnormal_basal_metabolism1.02982979
36MP0000470_abnormal_stomach_morphology1.02025328
37MP0002118_abnormal_lipid_homeostasis1.01414157
38MP0002078_abnormal_glucose_homeostasis0.97450283
39MP0003300_gastrointestinal_ulcer0.97124292
40MP0003045_fibrosis0.96712878
41MP0003119_abnormal_digestive_system0.95813251
42MP0009780_abnormal_chondrocyte_physiolo0.91718378
43MP0009840_abnormal_foam_cell0.90021259
44MP0009672_abnormal_birth_weight0.84903638
45MP0009703_decreased_birth_body0.84207315
46MP0009384_cardiac_valve_regurgitation0.83188547
47MP0008004_abnormal_stomach_pH0.81359876
48MP0000613_abnormal_salivary_gland0.80915312
49MP0004019_abnormal_vitamin_homeostasis0.78548803
50MP0002163_abnormal_gland_morphology0.77863431
51MP0002909_abnormal_adrenal_gland0.74585794
52MP0005332_abnormal_amino_acid0.73016972
53MP0000538_abnormal_urinary_bladder0.72841912
54MP0003121_genomic_imprinting0.72611216
55MP0005319_abnormal_enzyme/_coenzyme0.72575292
56MP0010329_abnormal_lipoprotein_level0.72084227
57MP0005165_increased_susceptibility_to0.71853666
58MP0005408_hypopigmentation0.70677925
59MP0000537_abnormal_urethra_morphology0.70160575
60MP0003115_abnormal_respiratory_system0.70147042
61MP0009643_abnormal_urine_homeostasis0.70018281
62MP0002277_abnormal_respiratory_mucosa0.69065115
63MP0000490_abnormal_crypts_of0.66653249
64MP0005451_abnormal_body_composition0.65601902
65MP0002896_abnormal_bone_mineralization0.65232964
66MP0003953_abnormal_hormone_level0.64101875
67MP0003656_abnormal_erythrocyte_physiolo0.62285810
68MP0000462_abnormal_digestive_system0.60645760
69MP0003879_abnormal_hair_cell0.59241963
70MP0008872_abnormal_physiological_respon0.59166874
71MP0005076_abnormal_cell_differentiation0.58527990
72MP0001501_abnormal_sleep_pattern0.58353738
73MP0003943_abnormal_hepatobiliary_system0.58240581
74MP0003942_abnormal_urinary_system0.57121774
75MP0003186_abnormal_redox_activity0.56271555
76MP0003941_abnormal_skin_development0.55867857
77MP0002938_white_spotting0.54797369
78MP0005375_adipose_tissue_phenotype0.52876077
79MP0001502_abnormal_circadian_rhythm0.51909591
80MP0001270_distended_abdomen0.51069734
81MP0004858_abnormal_nervous_system0.50705586
82MP0000598_abnormal_liver_morphology0.50353922
83MP0000013_abnormal_adipose_tissue0.50111388
84MP0004185_abnormal_adipocyte_glucose0.50008166
85MP0005187_abnormal_penis_morphology0.49843495
86MP0005636_abnormal_mineral_homeostasis0.49086577
87MP0001731_abnormal_postnatal_growth0.48740047
88MP0005452_abnormal_adipose_tissue0.48251462
89MP0002970_abnormal_white_adipose0.47608542
90MP0005623_abnormal_meninges_morphology0.47107147
91MP0008875_abnormal_xenobiotic_pharmacok0.46631070
92MP0002837_dystrophic_cardiac_calcinosis0.46479244
93MP0002060_abnormal_skin_morphology0.46123977
94MP0003566_abnormal_cell_adhesion0.46087886
95MP0001542_abnormal_bone_strength0.45613976
96MP0000367_abnormal_coat/_hair0.45597675
97MP0010678_abnormal_skin_adnexa0.45336401
98MP0004197_abnormal_fetal_growth/weight/0.44744744
99MP0001845_abnormal_inflammatory_respons0.44201653
100MP0009642_abnormal_blood_homeostasis0.42889671
101MP0001348_abnormal_lacrimal_gland0.41754728
102MP0008995_early_reproductive_senescence0.41730697
103MP0002796_impaired_skin_barrier0.41405142
104MP0001873_stomach_inflammation0.41316878
105MP0002098_abnormal_vibrissa_morphology0.41289544
106MP0001765_abnormal_ion_homeostasis0.41038159
107MP0000678_abnormal_parathyroid_gland0.40391381
108MP0005535_abnormal_body_temperature0.39864290
109MP0005379_endocrine/exocrine_gland_phen0.38679631
110MP0003436_decreased_susceptibility_to0.38427986
111MP0008469_abnormal_protein_level0.37110324
112MP0002877_abnormal_melanocyte_morpholog0.36190525
113MP0005381_digestive/alimentary_phenotyp0.35489918
114MP0003567_abnormal_fetal_cardiomyocyte0.34974273
115MP0000609_abnormal_liver_physiology0.34945840
116MP0000534_abnormal_ureter_morphology0.34757131
117MP0000377_abnormal_hair_follicle0.34671269
118MP0001340_abnormal_eyelid_morphology0.34488790
119MP0001849_ear_inflammation0.34361884
120MP0000566_synostosis0.33838816
121MP0002136_abnormal_kidney_physiology0.33686601
122MP0000681_abnormal_thyroid_gland0.33411604
123MP0002089_abnormal_postnatal_growth/wei0.33206950
124MP0000428_abnormal_craniofacial_morphol0.32430756
125MP0003828_pulmonary_edema0.31954597
126MP0005334_abnormal_fat_pad0.30188628
127MP0009765_abnormal_xenobiotic_induced0.30132395
128MP0001661_extended_life_span0.29653558
129MP0003646_muscle_fatigue0.29138125
130MP0010352_gastrointestinal_tract_polyps0.28705997
131MP0004043_abnormal_pH_regulation0.28500285
132MP0003866_abnormal_defecation0.28372354
133MP0000955_abnormal_spinal_cord0.27889697
134MP0002127_abnormal_cardiovascular_syste0.27822695
135MP0000750_abnormal_muscle_regeneration0.27552403
136MP0005058_abnormal_lysosome_morphology0.27439627
137MP0004134_abnormal_chest_morphology0.27007491
138MP0002295_abnormal_pulmonary_circulatio0.26563258
139MP0003795_abnormal_bone_structure0.26418447
140MP0004133_heterotaxia0.26304126
141MP0005275_abnormal_skin_tensile0.26216358
142MP0005646_abnormal_pituitary_gland0.26121586
143MP0000467_abnormal_esophagus_morphology0.25963725
144MP0002069_abnormal_eating/drinking_beha0.25749069
145MP0001963_abnormal_hearing_physiology0.24955174
146MP0002168_other_aberrant_phenotype0.23611733
147MP0001485_abnormal_pinna_reflex0.22853998
148MP0005595_abnormal_vascular_smooth0.22590049
149MP0005410_abnormal_fertilization0.21651351
150MP0005166_decreased_susceptibility_to0.18943058
151MP0005670_abnormal_white_adipose0.18017734

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)7.09025602
2Exocrine pancreatic insufficiency (HP:0001738)6.10850238
3Fat malabsorption (HP:0002630)5.91491965
4Abnormal pancreas size (HP:0012094)5.40848617
5Gout (HP:0001997)5.40730436
6Decreased subcutaneous fat (HP:0001002)5.28053501
7Hypoproteinemia (HP:0003075)5.17982161
8Abnormality of the pancreatic islet cells (HP:0006476)5.07809766
9Abnormality of endocrine pancreas physiology (HP:0012093)5.07809766
10Short chin (HP:0000331)4.92168058
11Abnormality of subcutaneous fat tissue (HP:0001001)4.78326144
12Type I diabetes mellitus (HP:0100651)4.60264786
13Maternal diabetes (HP:0009800)4.23574296
14Late onset (HP:0003584)4.00024750
15Ketoacidosis (HP:0001993)3.95797483
16Goiter (HP:0000853)3.68036239
17Abnormality of proline metabolism (HP:0010907)3.61993825
18Hydroxyprolinuria (HP:0003080)3.61993825
19Abnormality of the intrinsic pathway (HP:0010989)3.41431373
20Hyperinsulinemic hypoglycemia (HP:0000825)3.38286031
21Hypoglycemic coma (HP:0001325)3.25675802
22Joint stiffness (HP:0001387)3.22049092
23Pancreatitis (HP:0001733)3.17978236
24Hypoglycemic seizures (HP:0002173)3.16683289
25Ketosis (HP:0001946)3.14382867
26Tetraparesis (HP:0002273)3.09643241
27Pancreatic islet-cell hyperplasia (HP:0004510)3.09305388
28Tubulointerstitial fibrosis (HP:0005576)3.04509995
29Anal atresia (HP:0002023)2.97657870
30Hypotension (HP:0002615)2.88717622
31Hypoplasia of the pons (HP:0012110)2.85328208
32Large for gestational age (HP:0001520)2.75953951
33Sex reversal (HP:0012245)2.70942469
34Abnormal sex determination (HP:0012244)2.70942469
35Hyperglycemia (HP:0003074)2.67764028
36Rectal prolapse (HP:0002035)2.67289190
37Asymmetry of the thorax (HP:0001555)2.66361400
38Abnormality of aromatic amino acid family metabolism (HP:0004338)2.65558356
39Esophageal varix (HP:0002040)2.63795670
40Enlarged penis (HP:0000040)2.62641279
41Abnormality of glutamine family amino acid metabolism (HP:0010902)2.62054107
42Absent eyelashes (HP:0000561)2.57652911
43Vascular calcification (HP:0004934)2.57242110
44Lymphangioma (HP:0100764)2.57056513
45Abnormality of the pons (HP:0007361)2.56179853
46Congenital glaucoma (HP:0001087)2.54094441
47Unilateral renal agenesis (HP:0000122)2.51458283
48Abnormality of the nasal septum (HP:0000419)2.49332152
49Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.46357058
50Ankyloglossia (HP:0010296)2.45273275
51Congenital, generalized hypertrichosis (HP:0004540)2.42734668
52Premature skin wrinkling (HP:0100678)2.40906022
53Abnormality of the common coagulation pathway (HP:0010990)2.34081777
54Abnormality of the distal phalanges of the toes (HP:0010182)2.33249847
55Insulin resistance (HP:0000855)2.33083630
56Hepatoblastoma (HP:0002884)2.29326788
57Right ventricular cardiomyopathy (HP:0011663)2.27457692
58Germ cell neoplasia (HP:0100728)2.23954487
59Prenatal maternal abnormality (HP:0002686)2.22859403
60Cardiovascular calcification (HP:0011915)2.21701881
61Ventricular fibrillation (HP:0001663)2.20571890
62Pectus carinatum (HP:0000768)2.19607820
63Fragile skin (HP:0001030)2.18707651
64Stenosis of the external auditory canal (HP:0000402)2.18648645
65Hyperuricemia (HP:0002149)2.17133287
66Increased purine levels (HP:0004368)2.17133287
67Thin bony cortex (HP:0002753)2.16123854
68Symptomatic seizures (HP:0011145)2.12481167
69Facial shape deformation (HP:0011334)2.10804078
70Potter facies (HP:0002009)2.10804078
71Fatigue (HP:0012378)2.08682273
72Atrophic scars (HP:0001075)2.08460951
73Cortical dysplasia (HP:0002539)2.07041690
74Abnormality of dentin (HP:0010299)2.03577177
75Hyperphosphatemia (HP:0002905)2.03434029
76Diaphragmatic weakness (HP:0009113)2.02466191
77Male infertility (HP:0003251)2.00348789
78Enlarged kidneys (HP:0000105)1.99457171
79Thoracolumbar scoliosis (HP:0002944)1.96355073
80Insulin-resistant diabetes mellitus (HP:0000831)1.95932381
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95727323
82Barrel-shaped chest (HP:0001552)1.95329999
83Tubular atrophy (HP:0000092)1.93323311
84Testicular neoplasm (HP:0010788)1.92744476
85Optic nerve hypoplasia (HP:0000609)1.92678141
86Type II lissencephaly (HP:0007260)1.91684431
87Tubulointerstitial abnormality (HP:0001969)1.89782793
88Mitral valve prolapse (HP:0001634)1.88293752
89Abnormality of the renal cortex (HP:0011035)1.86824760
90Abnormality of purine metabolism (HP:0004352)1.86057968
91Renal duplication (HP:0000075)1.84287161
92Abnormal hemoglobin (HP:0011902)1.84172533
93Ileus (HP:0002595)1.83659881
94Patent foramen ovale (HP:0001655)1.83016229
95Rough bone trabeculation (HP:0100670)1.82935156
96Macroorchidism (HP:0000053)1.81229566
97Abnormality of the pleura (HP:0002103)1.80491771
98Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.79218558
99Abnormality of alanine metabolism (HP:0010916)1.79218558
100Hyperalaninemia (HP:0003348)1.79218558
101Paraparesis (HP:0002385)1.78940658
102Severe short stature (HP:0003510)1.78324507
103Carpal bone hypoplasia (HP:0001498)1.78027091
104Cerebral aneurysm (HP:0004944)1.77009684
105Ankle contracture (HP:0006466)1.76575534
106Tubulointerstitial nephritis (HP:0001970)1.76543369
107Neonatal death (HP:0003811)1.75742588
108Buphthalmos (HP:0000557)1.75053649
109Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)1.73115332
110Congenital malformation of the right heart (HP:0011723)1.72043799
111Double outlet right ventricle (HP:0001719)1.72043799
112Abnormality of oral frenula (HP:0000190)1.70944899
113Infantile muscular hypotonia (HP:0008947)1.70487190
114Abnormality of sulfur amino acid metabolism (HP:0004339)1.68953903
115Reduced antithrombin III activity (HP:0001976)1.67785428
116Progressive muscle weakness (HP:0003323)1.66833010
117Shallow orbits (HP:0000586)1.66695845
118Blue sclerae (HP:0000592)1.65139208
119Hyperextensible skin (HP:0000974)1.65097631
120Hypsarrhythmia (HP:0002521)1.63616004
121Mildly elevated creatine phosphokinase (HP:0008180)1.63371485
122Micronodular cirrhosis (HP:0001413)1.63198466
123Turricephaly (HP:0000262)1.63186824
124Abdominal pain (HP:0002027)1.63133583
125Disproportionate tall stature (HP:0001519)1.61737754
126Disproportionate short-trunk short stature (HP:0003521)1.60899426
127Protrusio acetabuli (HP:0003179)1.60665846
128Distal lower limb muscle weakness (HP:0009053)1.60346648
129Periodontitis (HP:0000704)1.59951681
130Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.59694720
131Abnormal biliary tract morphology (HP:0012440)1.59399294
132Biconcave vertebral bodies (HP:0004586)1.58899426
133Hypoplasia of the odontoid process (HP:0003311)1.57923819
134Abnormal tarsal ossification (HP:0008369)1.57151035
135Bladder diverticulum (HP:0000015)1.57000776
136Dysostosis multiplex (HP:0000943)1.56105403
137Abnormality of methionine metabolism (HP:0010901)1.55997965
138Abdominal distention (HP:0003270)1.55775252
139Glycosuria (HP:0003076)1.53814878
140Abnormality of urine glucose concentration (HP:0011016)1.53814878
141Type I transferrin isoform profile (HP:0003642)1.53201829
142Down-sloping shoulders (HP:0200021)1.51687454
143Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.49079248
144Abnormal protein N-linked glycosylation (HP:0012347)1.49079248
145Abnormal protein glycosylation (HP:0012346)1.49079248
146Abnormal glycosylation (HP:0012345)1.49079248
147Glossoptosis (HP:0000162)1.48604146
148Increased CSF protein (HP:0002922)1.46657169
149Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.45365526
150Popliteal pterygium (HP:0009756)1.44171237
151Glomerulonephritis (HP:0000099)1.43277511
152Gowers sign (HP:0003391)1.41951227
153Periauricular skin pits (HP:0100277)1.41890670
154Preauricular pit (HP:0004467)1.41890670
155Spinal muscular atrophy (HP:0007269)1.41860973
156Glucose intolerance (HP:0000833)1.41384972
157Sparse eyelashes (HP:0000653)1.39382743
158Abnormal trabecular bone morphology (HP:0100671)1.37764044
159Abnormality of aspartate family amino acid metabolism (HP:0010899)1.37035116
160Fetal akinesia sequence (HP:0001989)1.35973589
161Epiphyseal dysplasia (HP:0002656)1.34589152
162Renal salt wasting (HP:0000127)1.33836511
163Increased serum pyruvate (HP:0003542)1.32139739
164Stridor (HP:0010307)1.30526298
165Limb-girdle muscle atrophy (HP:0003797)1.25222674
166Hand muscle atrophy (HP:0009130)1.25193970
167Bifid uvula (HP:0000193)1.25174128
168Rhabdomyolysis (HP:0003201)1.23653754

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.34930453
2PDK25.33190993
3TRIB35.32829503
4PKN24.99042451
5ERN14.96193384
6MAP2K23.14374164
7STK242.89005714
8EIF2AK32.85920186
9INSRR2.75484363
10MAP3K122.43421982
11PTK62.29598670
12GRK12.16070844
13TAOK32.12938565
14PASK2.09326671
15RIPK11.96337500
16LATS11.95909072
17EEF2K1.93986544
18MAPK151.93731137
19OXSR11.76198733
20TBK11.74176368
21MAP3K61.74090877
22FLT31.73318530
23MAP3K101.73314932
24PDGFRA1.72275402
25SCYL21.72057456
26RPS6KB21.65406863
27PAK21.62780452
28ZAP701.47342278
29EIF2AK11.40170510
30PRKG21.39019918
31PRKD31.37406301
32FRK1.35181189
33WNK41.34216468
34BMPR1B1.31286175
35NEK61.29849258
36PDGFRB1.28761466
37LRRK21.25036810
38MST41.23542567
39FGFR41.21533114
40MAP3K21.21497921
41STK161.20547908
42MAP2K11.20158459
43SIK11.17234806
44IRAK11.15565162
45PTK21.15121452
46NLK1.14761417
47VRK21.12721878
48CAMKK11.10586678
49MTOR1.08487023
50FER1.05644171
51ERBB41.04727968
52MAPK71.03313705
53RET1.01004477
54MET0.98147256
55HIPK20.97243342
56IRAK20.95679803
57NTRK10.95321039
58MAPKAPK30.94060886
59PAK40.93197202
60DAPK10.92608623
61MAP3K10.91878368
62DYRK1B0.91632169
63EPHA30.90651510
64EPHB10.87769492
65PIM20.87548203
66DDR20.87508836
67MYLK0.83837263
68STK38L0.83760565
69ILK0.80624351
70NME10.80568518
71TRPM70.77477908
72NME20.77358449
73PRKCH0.76158241
74SGK30.72217007
75STK30.71470562
76PRKCI0.67480196
77TESK10.66807665
78CDK190.64416583
79CDK80.64189741
80TNIK0.61956748
81DAPK20.61148908
82IRAK30.56493212
83PRKCE0.55606085
84KSR20.51583612
85DYRK1A0.48998417
86MAP3K140.48108787
87TAOK10.46869599
88ERBB20.46207499
89SGK20.45456181
90IKBKE0.45135670
91SRPK10.44185226
92MUSK0.43934864
93PRKD10.43463759
94PRKD20.42740424
95ROCK10.40922513
96ICK0.39821814
97FGFR10.38881372
98LMTK20.38381237
99PRKCD0.38202377
100PRKCZ0.38064851
101MELK0.37706321
102IKBKB0.37667199
103CDK40.36318119
104EPHA20.35526899
105CSNK1E0.35467661
106MAPK120.34993879
107STK380.34678708
108CLK10.34050229
109WNK10.33588160
110MAPK10.32852544
111MAP3K70.32632946
112UHMK10.31744652
113CHUK0.31690627
114MAP3K80.31468616
115GSK3A0.30807566
116MAPK30.30566258
117PDPK10.29775260
118ALK0.29179611
119DAPK30.29157093
120VRK10.28893189
121PIK3CG0.28806659
122PRKAA10.28575299
123RPS6KA10.28497276
124PRKCQ0.28244209
125TYRO30.27443054
126JAK20.27351524
127MAP3K50.26803722
128SGK2230.25353548
129SGK4940.25353548
130TAOK20.25239630
131PRKACB0.25223854
132PAK30.24548941
133ADRBK20.23100799
134ERBB30.22525566
135TGFBR20.22209909
136PRKACA0.21619855
137SGK10.21213502
138AKT10.21130656
139TSSK60.20898289
140IGF1R0.20525195
141PRKCA0.20263259
142MAP3K30.20250073
143PRKAA20.19944614
144MAPK90.19689262
145PIK3CA0.19433152
146MST1R0.19074897
147CAMKK20.19026195
148AKT20.18087542
149STK390.17010647
150RPS6KB10.16060982
151FGFR20.15942246
152PDK10.15758467
153NTRK30.15253303
154CAMK1D0.14974136
155MARK20.14129145
156PRKDC0.13334465
157MAPK140.12418718
158CSNK1A1L0.12225314
159CDK60.12085815

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049728.16345373
2Fat digestion and absorption_Homo sapiens_hsa049756.15805400
3Maturity onset diabetes of the young_Homo sapiens_hsa049505.83342621
4* Protein digestion and absorption_Homo sapiens_hsa049745.78928186
5Protein export_Homo sapiens_hsa030602.96854995
6Glycerolipid metabolism_Homo sapiens_hsa005612.93150856
7Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.55025914
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.93249315
9Folate biosynthesis_Homo sapiens_hsa007901.88642491
10Cyanoamino acid metabolism_Homo sapiens_hsa004601.76922108
11Steroid biosynthesis_Homo sapiens_hsa001001.67455032
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.53868191
13Notch signaling pathway_Homo sapiens_hsa043301.32328734
14N-Glycan biosynthesis_Homo sapiens_hsa005101.24716392
15Insulin secretion_Homo sapiens_hsa049111.23237770
16Ether lipid metabolism_Homo sapiens_hsa005651.22523310
17Arachidonic acid metabolism_Homo sapiens_hsa005901.20111996
18Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.03499630
19Renin-angiotensin system_Homo sapiens_hsa046141.00255229
20Carbohydrate digestion and absorption_Homo sapiens_hsa049730.96838087
21Glutathione metabolism_Homo sapiens_hsa004800.95709233
22Propanoate metabolism_Homo sapiens_hsa006400.91388792
23Pentose and glucuronate interconversions_Homo sapiens_hsa000400.88147622
24Vitamin digestion and absorption_Homo sapiens_hsa049770.87659167
25Arginine and proline metabolism_Homo sapiens_hsa003300.86405998
26Selenocompound metabolism_Homo sapiens_hsa004500.85410723
27Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.84936798
28Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.82145545
29Vitamin B6 metabolism_Homo sapiens_hsa007500.79680863
30Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79559013
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77592711
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70941755
33Biosynthesis of amino acids_Homo sapiens_hsa012300.69964183
34Vibrio cholerae infection_Homo sapiens_hsa051100.69379127
35Starch and sucrose metabolism_Homo sapiens_hsa005000.67571164
36Influenza A_Homo sapiens_hsa051640.66222820
37Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.65928003
38Sulfur metabolism_Homo sapiens_hsa009200.64347675
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63702852
40Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63113120
41Circadian rhythm_Homo sapiens_hsa047100.63092756
42Chemical carcinogenesis_Homo sapiens_hsa052040.63044129
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.62363060
44alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.57775454
45Steroid hormone biosynthesis_Homo sapiens_hsa001400.57629275
46Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54796107
47Linoleic acid metabolism_Homo sapiens_hsa005910.53589008
48Nitrogen metabolism_Homo sapiens_hsa009100.52842587
49One carbon pool by folate_Homo sapiens_hsa006700.48756922
50Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.48383808
51Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47030385
52Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.46707477
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46460317
54Retinol metabolism_Homo sapiens_hsa008300.44932232
55Endometrial cancer_Homo sapiens_hsa052130.43884417
56Fatty acid degradation_Homo sapiens_hsa000710.43496869
57Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.42906543
58Tryptophan metabolism_Homo sapiens_hsa003800.42094411
59Bladder cancer_Homo sapiens_hsa052190.42037721
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.41059210
61Cocaine addiction_Homo sapiens_hsa050300.39066528
62Thyroid hormone synthesis_Homo sapiens_hsa049180.38654111
63Estrogen signaling pathway_Homo sapiens_hsa049150.38349023
64Lysine degradation_Homo sapiens_hsa003100.37924746
65Complement and coagulation cascades_Homo sapiens_hsa046100.37709380
66Thyroid cancer_Homo sapiens_hsa052160.37318749
67Tight junction_Homo sapiens_hsa045300.37229938
68Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36696900
69Type II diabetes mellitus_Homo sapiens_hsa049300.35978861
70Other glycan degradation_Homo sapiens_hsa005110.35805392
71Insulin resistance_Homo sapiens_hsa049310.34786579
72beta-Alanine metabolism_Homo sapiens_hsa004100.34628340
73mTOR signaling pathway_Homo sapiens_hsa041500.33360344
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.33350589
75Hepatitis C_Homo sapiens_hsa051600.32978089
76Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.32652618
77Sulfur relay system_Homo sapiens_hsa041220.32001491
78VEGF signaling pathway_Homo sapiens_hsa043700.29648314
79Pyruvate metabolism_Homo sapiens_hsa006200.29177943
80Adherens junction_Homo sapiens_hsa045200.29097004
81Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.28418353
82Type I diabetes mellitus_Homo sapiens_hsa049400.28146842
83Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.28087649
84Prostate cancer_Homo sapiens_hsa052150.27870748
85Aldosterone synthesis and secretion_Homo sapiens_hsa049250.27144027
86Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.26446236
87Metabolic pathways_Homo sapiens_hsa011000.26223979
88Mineral absorption_Homo sapiens_hsa049780.25683195
89Longevity regulating pathway - mammal_Homo sapiens_hsa042110.23404235
90Legionellosis_Homo sapiens_hsa051340.22859648
91Lysosome_Homo sapiens_hsa041420.21144138
92Bile secretion_Homo sapiens_hsa049760.18791585
93ECM-receptor interaction_Homo sapiens_hsa045120.17683713
94Peroxisome_Homo sapiens_hsa041460.17428157
95Sphingolipid metabolism_Homo sapiens_hsa006000.16910365
96Ovarian steroidogenesis_Homo sapiens_hsa049130.16426743
97Phototransduction_Homo sapiens_hsa047440.16230548
98Pentose phosphate pathway_Homo sapiens_hsa000300.15382483
99Primary bile acid biosynthesis_Homo sapiens_hsa001200.15347430
100Insulin signaling pathway_Homo sapiens_hsa049100.15292114
101Gastric acid secretion_Homo sapiens_hsa049710.15120619
102Prion diseases_Homo sapiens_hsa050200.15112231
103Proteasome_Homo sapiens_hsa030500.14729220
104Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.14612280
105Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14466314
106Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.12967583
107Neurotrophin signaling pathway_Homo sapiens_hsa047220.12625197
108Glucagon signaling pathway_Homo sapiens_hsa049220.11552557
109Focal adhesion_Homo sapiens_hsa045100.11191190
110Vascular smooth muscle contraction_Homo sapiens_hsa042700.10421256
111Arginine biosynthesis_Homo sapiens_hsa002200.10217035
112Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10189088
113Histidine metabolism_Homo sapiens_hsa003400.09773054
114Glycosaminoglycan degradation_Homo sapiens_hsa005310.09713007
115Viral myocarditis_Homo sapiens_hsa054160.09566658
116Butanoate metabolism_Homo sapiens_hsa006500.09465586
117TGF-beta signaling pathway_Homo sapiens_hsa043500.09460005
118Fatty acid elongation_Homo sapiens_hsa000620.08854074
119Ribosome_Homo sapiens_hsa030100.08773539
120Cholinergic synapse_Homo sapiens_hsa047250.08638889
121Regulation of autophagy_Homo sapiens_hsa041400.08457401
122Pancreatic cancer_Homo sapiens_hsa052120.08386284
123Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.08333795
124Carbon metabolism_Homo sapiens_hsa012000.07544006
125Non-small cell lung cancer_Homo sapiens_hsa052230.07451257
126AMPK signaling pathway_Homo sapiens_hsa041520.07279930
127Toxoplasmosis_Homo sapiens_hsa051450.07184461
128Hippo signaling pathway_Homo sapiens_hsa043900.06890695
129Platelet activation_Homo sapiens_hsa046110.05769963
130Calcium signaling pathway_Homo sapiens_hsa040200.05277444
131Galactose metabolism_Homo sapiens_hsa000520.05250118
132Central carbon metabolism in cancer_Homo sapiens_hsa052300.05239290
133Small cell lung cancer_Homo sapiens_hsa052220.03962206
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.03739789
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.03327159
136Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.02113133
137Fructose and mannose metabolism_Homo sapiens_hsa000510.01647552
138Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.01639972
139ABC transporters_Homo sapiens_hsa020100.00458431
140HIF-1 signaling pathway_Homo sapiens_hsa04066-0.1061659
141TNF signaling pathway_Homo sapiens_hsa04668-0.0967729
142SNARE interactions in vesicular transport_Homo sapiens_hsa04130-0.0897593
143Tyrosine metabolism_Homo sapiens_hsa00350-0.0742923
144Ras signaling pathway_Homo sapiens_hsa04014-0.0733118
145Collecting duct acid secretion_Homo sapiens_hsa04966-0.0579226
146Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514-0.0089512
147Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0021520
148Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0019878

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