CTRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of epidermal cell differentiation (GO:0045605)8.51177441
2regulation of phospholipase A2 activity (GO:0032429)7.92352095
3daunorubicin metabolic process (GO:0044597)7.62819684
4polyketide metabolic process (GO:0030638)7.62819684
5doxorubicin metabolic process (GO:0044598)7.62819684
6transcytosis (GO:0045056)6.99147600
7intestinal absorption (GO:0050892)6.89921929
8aminoglycoside antibiotic metabolic process (GO:0030647)6.77242763
9glycolipid catabolic process (GO:0019377)6.70605171
10negative regulation of epidermis development (GO:0045683)6.35203014
11positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003606.25979604
12leukotriene biosynthetic process (GO:0019370)6.14976245
13calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.75263240
14regulation of acrosome reaction (GO:0060046)5.65021969
15* tetrapyrrole metabolic process (GO:0033013)5.62972077
16membrane lipid catabolic process (GO:0046466)5.59433501
17regulation of hormone metabolic process (GO:0032350)5.50178553
18phosphatidylserine acyl-chain remodeling (GO:0036150)5.45551697
19phosphatidylglycerol acyl-chain remodeling (GO:0036148)5.31153159
20neutrophil mediated immunity (GO:0002446)5.16364454
21phosphatidylinositol acyl-chain remodeling (GO:0036149)5.14359215
22maintenance of gastrointestinal epithelium (GO:0030277)5.10594015
23regulation of metalloenzyme activity (GO:0048552)5.00591247
24acute-phase response (GO:0006953)4.89046465
25icosanoid secretion (GO:0032309)4.72116790
26arachidonic acid secretion (GO:0050482)4.72116790
27regulation of keratinocyte differentiation (GO:0045616)4.68921834
28glutathione derivative metabolic process (GO:1901685)4.65032548
29glutathione derivative biosynthetic process (GO:1901687)4.65032548
30long term synaptic depression (GO:0060292)4.58886385
31peptide catabolic process (GO:0043171)4.58595555
32* water-soluble vitamin metabolic process (GO:0006767)4.48264409
33protein retention in ER lumen (GO:0006621)4.46613181
34leukotriene metabolic process (GO:0006691)4.43957493
35peroxisome fission (GO:0016559)4.40799315
36glutathione biosynthetic process (GO:0006750)4.37238168
37hydrogen peroxide metabolic process (GO:0042743)4.35984503
38regulation of keratinocyte proliferation (GO:0010837)4.31908815
39peptidyl-proline hydroxylation (GO:0019511)4.30901043
40cysteine metabolic process (GO:0006534)4.25520031
41icosanoid transport (GO:0071715)4.02481417
42fatty acid derivative transport (GO:1901571)4.02481417
43nonribosomal peptide biosynthetic process (GO:0019184)3.99635517
44maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.97451909
45vitamin A metabolic process (GO:0006776)3.90296297
46phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.88341192
47regulation of response to osmotic stress (GO:0047484)3.87166061
48cellular protein catabolic process (GO:0044257)3.74395992
49progesterone metabolic process (GO:0042448)3.73745238
50phosphatidylserine metabolic process (GO:0006658)3.73486811
51digestive system process (GO:0022600)3.67591044
52negative regulation of hormone metabolic process (GO:0032351)3.59949149
53* vitamin metabolic process (GO:0006766)3.59444018
54innate immune response in mucosa (GO:0002227)3.59264823
55myeloid leukocyte mediated immunity (GO:0002444)3.57617801
56primary alcohol catabolic process (GO:0034310)3.52845619
57glycoside metabolic process (GO:0016137)3.51453595
58epithelial structure maintenance (GO:0010669)3.49295092
59ceramide catabolic process (GO:0046514)3.48718572
60regulation of triglyceride catabolic process (GO:0010896)3.45715191
61protein hydroxylation (GO:0018126)3.43016474
62acute inflammatory response (GO:0002526)3.37252043
63fatty acid derivative biosynthetic process (GO:1901570)3.33968664
64icosanoid biosynthetic process (GO:0046456)3.33968664
65regulation of calcium ion import (GO:0090279)3.32477399
66phospholipid catabolic process (GO:0009395)3.28781150
67peptide biosynthetic process (GO:0043043)3.23277292
68phosphatidylcholine acyl-chain remodeling (GO:0036151)3.22813153
69regulation of retinoic acid receptor signaling pathway (GO:0048385)3.18748081
70mitochondrial calcium ion transport (GO:0006851)3.18392220
71sterol catabolic process (GO:0016127)3.14913542
72cholesterol catabolic process (GO:0006707)3.14913542
73water-soluble vitamin biosynthetic process (GO:0042364)3.12502287
74retinoid metabolic process (GO:0001523)3.12101802
75retinal metabolic process (GO:0042574)3.08174404
76alditol phosphate metabolic process (GO:0052646)3.06005083
77negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.05766713
78positive regulation of wound healing (GO:0090303)3.04696775
79* extracellular matrix disassembly (GO:0022617)3.02296321
80phosphatidic acid metabolic process (GO:0046473)3.01508945
81phosphatidic acid biosynthetic process (GO:0006654)3.01508945
82renal absorption (GO:0070293)3.01239293
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.99711814
84nucleotide-sugar biosynthetic process (GO:0009226)2.97701779
85macroautophagy (GO:0016236)2.97366774
86regulation of cellular amino acid metabolic process (GO:0006521)2.94929144
87diterpenoid metabolic process (GO:0016101)2.92421566
88mucosal immune response (GO:0002385)2.90848938
89phototransduction, visible light (GO:0007603)2.89755445
90cellular response to cadmium ion (GO:0071276)2.86889602
91regulation of epidermal cell differentiation (GO:0045604)2.86593304
92hypotonic response (GO:0006971)2.86211910
93sterol transport (GO:0015918)2.79560010
94cholesterol transport (GO:0030301)2.79560010
95cellular response to zinc ion (GO:0071294)2.78922614
96glutathione metabolic process (GO:0006749)2.77876013
97quinone metabolic process (GO:1901661)2.76428811
98* cobalamin metabolic process (GO:0009235)17.1080698
99* digestion (GO:0007586)16.7377371
100intestinal cholesterol absorption (GO:0030299)14.9648447

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.22288155
2FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.11442326
3ESR1_21235772_ChIP-Seq_MCF-7_Human2.93215613
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.69343355
5GATA4_25053715_ChIP-Seq_YYC3_Human2.62117799
6PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse2.56066387
7ESR2_21235772_ChIP-Seq_MCF-7_Human2.55483862
8PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.34568978
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.32575968
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.32575968
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.32575968
12GATA6_25053715_ChIP-Seq_YYC3_Human2.16187917
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13771365
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat14.2113584
15SOX2_20726797_ChIP-Seq_SW620_Human1.96955034
16SOX2_27498859_Chip-Seq_STOMACH_Mouse1.81673606
17HTT_18923047_ChIP-ChIP_STHdh_Human1.78131390
18FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.75667846
19RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74190893
20ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.72728633
21ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.70958758
22EGR1_19032775_ChIP-ChIP_M12_Human1.63285189
23LXR_22158963_ChIP-Seq_LIVER_Mouse1.58317414
24FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.53085677
25PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45347800
26PPAR_26484153_Chip-Seq_NCI-H1993_Human1.44269081
27FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.44125658
28CDX2_20551321_ChIP-Seq_CACO-2_Human1.43046012
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.34837883
30RXR_22158963_ChIP-Seq_LIVER_Mouse1.32724789
31TCF4_18268006_ChIP-ChIP_LS174T_Human1.31682128
32JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28395607
33TAF2_19829295_ChIP-Seq_ESCs_Human1.25523168
34EGR1_23403033_ChIP-Seq_LIVER_Mouse1.23272913
35JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.19357965
36CJUN_26792858_Chip-Seq_BT549_Human1.19052577
37FOXO3_23340844_ChIP-Seq_DLD1_Human1.18163636
38SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.12701067
39FOXA1_25552417_ChIP-Seq_VCAP_Human1.11861960
40PHF8_20622853_ChIP-Seq_HELA_Human1.11306932
41ERA_21632823_ChIP-Seq_H3396_Human1.10452245
42IRF8_22096565_ChIP-ChIP_GC-B_Human1.10097457
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.09586559
44FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.08548683
45FOXA1_21572438_ChIP-Seq_LNCaP_Human1.08052660
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.08022465
47GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.06702727
48ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06636712
49PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.06197860
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.06005659
51ETV1_20927104_ChIP-Seq_GIST48_Human1.05271006
52HNFA_21074721_ChIP-Seq_CACO-2_Human1.04766389
53AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.04182143
54CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.03845806
55GATA3_20176728_ChIP-ChIP_TSCs_Mouse1.02767802
56PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.02200805
57FOXH1_21741376_ChIP-Seq_EPCs_Human1.01058759
58E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99976374
59RBPJ_21746931_ChIP-Seq_IB4_Human0.99824717
60GATA6_21074721_ChIP-Seq_CACO-2_Human0.98540107
61FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.96994543
62NFYA_21822215_ChIP-Seq_K562_Human0.96247519
63ZNF217_24962896_ChIP-Seq_MCF-7_Human0.95656692
64P300_27268052_Chip-Seq_Bcells_Human0.94870170
65FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.93543319
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92751820
67HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92482930
68EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.92339266
69SALL4_18804426_ChIP-ChIP_XEN_Mouse0.91612410
70AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.90064500
71PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.87284044
72GATA3_24758297_ChIP-Seq_MCF-7_Human0.86912648
73CDX2_19796622_ChIP-Seq_MESCs_Mouse0.83865722
74ESET_19884257_ChIP-Seq_ESCs_Mouse0.83619230
75FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.83399405
76ERG_21242973_ChIP-ChIP_JURKAT_Human0.83204866
77VDR_22108803_ChIP-Seq_LS180_Human0.82534356
78FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82188233
79FOXA1_25329375_ChIP-Seq_VCAP_Human0.82188233
80P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81775175
81CBX2_22325352_ChIP-Seq_293T-Rex_Human0.80120521
82AR_20517297_ChIP-Seq_VCAP_Human0.79437404
83NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.79397038
84HNF4A_19822575_ChIP-Seq_HepG2_Human0.76940640
85NFYB_21822215_ChIP-Seq_K562_Human0.76734992
86CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76622494
87ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.76079547
88FLI1_21867929_ChIP-Seq_CD8_Mouse0.75705106
89SMAD4_21741376_ChIP-Seq_EPCs_Human0.75349174
90IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.74494398
91ETV2_25802403_ChIP-Seq_MESCs_Mouse0.73425333
92FOXM1_26456572_ChIP-Seq_MCF-7_Human0.73336804
93KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.73037036
94AHR_22903824_ChIP-Seq_MCF-7_Human0.72953372
95CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.72553131
96GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72233599
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.71782204
98BCOR_27268052_Chip-Seq_Bcells_Human0.71140780
99SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.70718353
100SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.70718353

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt7.38467563
2MP0003868_abnormal_feces_composition7.02542447
3MP0005083_abnormal_biliary_tract6.20738862
4MP0002876_abnormal_thyroid_physiology4.21575888
5MP0010386_abnormal_urinary_bladder3.05947624
6MP0005085_abnormal_gallbladder_physiolo2.90678396
7MP0003011_delayed_dark_adaptation2.77561020
8MP0005220_abnormal_exocrine_pancreas2.72600195
9MP0002138_abnormal_hepatobiliary_system2.52836071
10MP0005084_abnormal_gallbladder_morpholo2.30457670
11MP0001666_abnormal_nutrient_absorption11.2675797
12MP0003959_abnormal_lean_body1.98894940
13MP0002089_abnormal_postnatal_growth/wei1.69257345
14MP0002139_abnormal_hepatobiliary_system1.63437962
15MP0010329_abnormal_lipoprotein_level1.57477912
16MP0002693_abnormal_pancreas_physiology1.55792210
17MP0001873_stomach_inflammation1.52241708
18MP0003195_calcinosis1.49053892
19MP0001756_abnormal_urination1.43308573
20MP0002118_abnormal_lipid_homeostasis1.37729348
21MP0001664_abnormal_digestion1.26605335
22MP0009840_abnormal_foam_cell1.24491978
23MP0003186_abnormal_redox_activity1.19196058
24MP0000538_abnormal_urinary_bladder1.17637061
25MP0004019_abnormal_vitamin_homeostasis1.15165852
26MP0005448_abnormal_energy_balance1.11606563
27MP0000613_abnormal_salivary_gland1.10659645
28MP0010234_abnormal_vibrissa_follicle1.05658831
29MP0001661_extended_life_span1.04430334
30MP0002928_abnormal_bile_duct1.03751535
31MP0005319_abnormal_enzyme/_coenzyme1.02186911
32MP0003656_abnormal_erythrocyte_physiolo1.00211446
33MP0009780_abnormal_chondrocyte_physiolo0.97976487
34MP0002132_abnormal_respiratory_system0.97851215
35MP0003953_abnormal_hormone_level0.97733039
36MP0008004_abnormal_stomach_pH0.95750345
37MP0005452_abnormal_adipose_tissue0.93337999
38MP0001944_abnormal_pancreas_morphology0.91241731
39MP0003943_abnormal_hepatobiliary_system0.89327571
40MP0001542_abnormal_bone_strength0.86786178
41MP0002909_abnormal_adrenal_gland0.85584872
42MP0003300_gastrointestinal_ulcer0.85200668
43MP0009643_abnormal_urine_homeostasis0.84962478
44MP0004264_abnormal_extraembryonic_tissu0.84804648
45MP0002078_abnormal_glucose_homeostasis0.84680103
46MP0008872_abnormal_physiological_respon0.83560340
47MP0003879_abnormal_hair_cell0.78249668
48MP0008875_abnormal_xenobiotic_pharmacok0.70336747
49MP0005332_abnormal_amino_acid0.70129496
50MP0005636_abnormal_mineral_homeostasis0.64173093
51MP0000598_abnormal_liver_morphology0.63688564
52MP0001501_abnormal_sleep_pattern0.63303194
53MP0005334_abnormal_fat_pad0.60790557
54MP0005451_abnormal_body_composition0.59863545
55MP0002163_abnormal_gland_morphology0.56429068
56MP0008995_early_reproductive_senescence0.55109966
57MP0003436_decreased_susceptibility_to0.54913187
58MP0001731_abnormal_postnatal_growth0.54773639
59MP0002295_abnormal_pulmonary_circulatio0.54199379
60MP0002277_abnormal_respiratory_mucosa0.53539582
61MP0000685_abnormal_immune_system0.53241080
62MP0008469_abnormal_protein_level0.52891887
63MP0002735_abnormal_chemical_nociception0.52222783
64MP0001963_abnormal_hearing_physiology0.50828990
65MP0000367_abnormal_coat/_hair0.50735206
66MP0005647_abnormal_sex_gland0.50462283
67MP0003283_abnormal_digestive_organ0.50282726
68MP0005167_abnormal_blood-brain_barrier0.48995792
69MP0005646_abnormal_pituitary_gland0.47349944
70MP0006036_abnormal_mitochondrial_physio0.46787511
71MP0003252_abnormal_bile_duct0.45791585
72MP0000462_abnormal_digestive_system0.44361192
73MP0002136_abnormal_kidney_physiology0.44228670
74MP0005410_abnormal_fertilization0.43754596
75MP0005408_hypopigmentation0.42884099
76MP0009642_abnormal_blood_homeostasis0.42858583
77MP0000681_abnormal_thyroid_gland0.42522690
78MP0001765_abnormal_ion_homeostasis0.42274189
79MP0001764_abnormal_homeostasis0.42116723
80MP0003075_altered_response_to0.39358187
81MP0002796_impaired_skin_barrier0.39354031
82MP0003938_abnormal_ear_development0.37084927
83MP0000631_abnormal_neuroendocrine_gland0.36363883
84MP0002970_abnormal_white_adipose0.36331215
85MP0009333_abnormal_splenocyte_physiolog0.35572637
86MP0001845_abnormal_inflammatory_respons0.34833991
87MP0006035_abnormal_mitochondrial_morpho0.34472104
88MP0000371_diluted_coat_color0.33923278
89MP0002166_altered_tumor_susceptibility0.33907356
90MP0000609_abnormal_liver_physiology0.32858896
91MP0002127_abnormal_cardiovascular_syste0.32311687
92MP0003866_abnormal_defecation0.31811315
93MP0003828_pulmonary_edema0.31136654
94MP0001730_embryonic_growth_arrest0.29516013
95MP0001533_abnormal_skeleton_physiology0.29332707
96MP0002168_other_aberrant_phenotype0.28763191
97MP0004233_abnormal_muscle_weight0.28721410
98MP0003453_abnormal_keratinocyte_physiol0.28504514
99MP0003045_fibrosis0.26617483
100MP0000470_abnormal_stomach_morphology0.26507521

Predicted human phenotypes

RankGene SetZ-score
1Pancreatitis (HP:0001733)5.39769920
2Goiter (HP:0000853)4.95550997
3Gout (HP:0001997)4.73252716
4Tubulointerstitial nephritis (HP:0001970)4.28290892
5Abnormality of proline metabolism (HP:0010907)4.23030513
6Hydroxyprolinuria (HP:0003080)4.23030513
7Abnormality of the pleura (HP:0002103)3.86001675
8Increased purine levels (HP:0004368)3.61631457
9Hyperuricemia (HP:0002149)3.61631457
10Rough bone trabeculation (HP:0100670)3.06916711
11Diaphragmatic weakness (HP:0009113)3.06549990
12Tubulointerstitial fibrosis (HP:0005576)2.98616717
13Abnormality of the distal phalanges of the toes (HP:0010182)2.87805411
14Abnormality of glutamine family amino acid metabolism (HP:0010902)2.83638365
15Anal atresia (HP:0002023)2.83108305
16Abnormal pancreas size (HP:0012094)2.81844464
17Tetraparesis (HP:0002273)2.76346820
18Spinal muscular atrophy (HP:0007269)2.76170548
19Increased serum pyruvate (HP:0003542)2.65832465
20Sex reversal (HP:0012245)2.64385350
21Abnormal sex determination (HP:0012244)2.64385350
22Abnormality of purine metabolism (HP:0004352)2.64244978
23Carpal bone hypoplasia (HP:0001498)2.63481318
24Barrel-shaped chest (HP:0001552)2.58949504
25Tubular atrophy (HP:0000092)2.51578362
26Aplasia/Hypoplasia of the abdominal wall musculature (HP:0010318)2.50067690
27Hand muscle atrophy (HP:0009130)2.48543544
28Stridor (HP:0010307)2.45197284
29Abnormality of glycolysis (HP:0004366)2.44619080
30Distal lower limb muscle weakness (HP:0009053)2.43844164
31Disproportionate short-trunk short stature (HP:0003521)2.43824611
32Fetal akinesia sequence (HP:0001989)2.41291271
33Congenital, generalized hypertrichosis (HP:0004540)2.32179233
34Aplasia of the musculature (HP:0100854)2.30400376
35Hyperphosphatemia (HP:0002905)2.29100788
36Abnormality of alanine metabolism (HP:0010916)2.27583665
37Hyperalaninemia (HP:0003348)2.27583665
38Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.27583665
39Abnormal trabecular bone morphology (HP:0100671)2.25711106
40Patent foramen ovale (HP:0001655)2.24991265
41Large for gestational age (HP:0001520)2.24785756
42Glucose intolerance (HP:0000833)2.23688694
43Muscle fiber splitting (HP:0003555)2.21619731
44Tubulointerstitial abnormality (HP:0001969)2.19289167
45Obstructive sleep apnea (HP:0002870)2.17863445
46Abnormality of the renal cortex (HP:0011035)2.16208880
47Abnormality of the nasal septum (HP:0000419)2.15125294
48Limb-girdle muscle atrophy (HP:0003797)2.06713518
49Vascular calcification (HP:0004934)2.06406486
50Steatorrhea (HP:0002570)15.5643212
51Fat malabsorption (HP:0002630)11.9113892
52Exocrine pancreatic insufficiency (HP:0001738)11.6042854
53Hypoproteinemia (HP:0003075)11.5304417
54Hypoglycemic coma (HP:0001325)1.93015567
55Type II lissencephaly (HP:0007260)1.91885849
56Hypoplasia of the odontoid process (HP:0003311)1.90529104
57Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83954058
58Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83954058
59Abnormality of the middle phalanges of the toes (HP:0010183)1.82808581
60Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.80041954
61Glycosuria (HP:0003076)1.80012903
62Abnormality of urine glucose concentration (HP:0011016)1.80012903
63Down-sloping shoulders (HP:0200021)1.79969325
64Renal salt wasting (HP:0000127)1.79529905
65Distal upper limb amyotrophy (HP:0007149)1.77646417
66Upper limb amyotrophy (HP:0009129)1.77646417
67Hepatic necrosis (HP:0002605)1.76136105
68Epiphyseal dysplasia (HP:0002656)1.75711300
69Cardiovascular calcification (HP:0011915)1.75149786
70Abnormal gallbladder physiology (HP:0012438)1.69763139
71Cholecystitis (HP:0001082)1.69763139
72Male infertility (HP:0003251)1.68141005
73Sparse eyelashes (HP:0000653)1.67759231
74Hyperinsulinemic hypoglycemia (HP:0000825)1.66869554
75Rhabdomyolysis (HP:0003201)1.66294902
76Abnormality of nucleobase metabolism (HP:0010932)1.62438480
77Glomerulonephritis (HP:0000099)1.62219332
78Paraparesis (HP:0002385)1.62076970
79Flat acetabular roof (HP:0003180)1.57074512
80Hepatocellular necrosis (HP:0001404)1.55199804
81Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.52963314
82Spinal cord compression (HP:0002176)1.52028468
83Abdominal pain (HP:0002027)1.51505005
84Nonprogressive disorder (HP:0003680)1.50872876
85Dyskinesia (HP:0100660)1.49552621
86Glomerulosclerosis (HP:0000096)1.47889353
87Late onset (HP:0003584)1.46828130
88Insulin-resistant diabetes mellitus (HP:0000831)1.45678168
89Depressed nasal tip (HP:0000437)1.45123450
90Gowers sign (HP:0003391)1.44302258
91Abnormal vertebral ossification (HP:0100569)1.44141584
92Median cleft lip (HP:0000161)1.43632844
93Abnormality of the vocal cords (HP:0008777)1.43233391
94Loss of speech (HP:0002371)1.42895528
95Abnormal glucose tolerance (HP:0001952)1.42850693
96Increased CSF protein (HP:0002922)1.41978845
97Abnormality of the odontoid process (HP:0003310)1.41448221
98Tetraplegia (HP:0002445)1.41260849
99Abnormal hemoglobin (HP:0011902)1.35505917
100Hypoglycemic seizures (HP:0002173)1.33105999

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK25.40256464
2STK244.72369413
3LMTK24.70602059
4MAP3K63.86578060
5STK393.40288784
6VRK23.27854689
7EPHA23.20521850
8MAPKAPK33.06275612
9MAP3K122.77375223
10EIF2AK32.70209993
11OXSR12.25285475
12MAP3K32.19701726
13ZAP702.09453240
14TBK12.03155826
15STK161.84466083
16TAOK31.77753158
17ERN11.75343612
18MST1R1.75004938
19INSRR1.65169235
20GRK11.62278207
21NME11.52094156
22TNIK1.51121084
23NEK61.38397046
24MAPK71.36381577
25BMPR1B1.36099135
26EIF2AK11.35474796
27DAPK11.28251328
28MST41.23289212
29SRPK11.18485533
30ICK1.17099155
31SCYL21.16940791
32STK38L1.15907535
33MAP3K21.14498567
34ERBB41.11791842
35MYLK1.10225706
36NLK1.10032593
37CLK11.09712487
38PRKG21.02080124
39STK30.95353790
40NTRK30.94317348
41VRK10.91376000
42PIK3CA0.88327391
43IRAK10.88284422
44EPHA30.82777639
45CDK190.78835251
46PASK0.75567999
47FER0.75296324
48CDK80.69540204
49BCKDK0.67987666
50TNK20.66186355
51PIM20.66101390
52IRAK20.64234941
53TRPM70.63861990
54PRKCD0.63286517
55DAPK20.61144281
56IKBKE0.59326662
57IKBKB0.57452015
58FRK0.57381897
59MET0.56907864
60RPS6KB20.55262616
61PIK3CG0.50646986
62PTK20.50526239
63FGFR40.49165226
64PDGFRB0.48168826
65MAPK120.48100183
66LRRK20.45896918
67SGK30.45497359
68WNK40.44880824
69ILK0.43102475
70AKT30.42793210
71PRKCE0.41014731
72TGFBR20.40191748
73MELK0.39917955
74PRKCQ0.37080113
75MAPK150.36603767
76AKT20.33213413
77TESK10.33105023
78MAP2K10.31955556
79MAP3K70.31935104
80ROCK10.31800522
81PHKG10.30903973
82PHKG20.30903973
83PINK10.29941688
84IGF1R0.28313548
85DAPK30.26165300
86MAP3K140.24485926
87EGFR0.24164222
88ERBB30.23840990
89TYK20.23137544
90MAP3K40.22640690
91ADRBK20.22476475
92PRKACA0.22301073
93MAP4K20.21307383
94CAMK1D0.21128913
95CHUK0.20454605
96PRKCA0.20246183
97MAPK110.17100072
98EPHB10.16932860
99SGK10.15541941
100NEK90.13677733

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049729.53991336
2Protein digestion and absorption_Homo sapiens_hsa049747.07422299
3Fat digestion and absorption_Homo sapiens_hsa049756.64658919
4Glycerolipid metabolism_Homo sapiens_hsa005613.02932844
5Cyanoamino acid metabolism_Homo sapiens_hsa004602.65692514
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.47172131
7Renin-angiotensin system_Homo sapiens_hsa046142.16063072
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.00680548
9Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.87625780
10Vitamin digestion and absorption_Homo sapiens_hsa049771.75418601
11Sulfur metabolism_Homo sapiens_hsa009201.68793061
12Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.63984925
13Starch and sucrose metabolism_Homo sapiens_hsa005001.55648074
14Linoleic acid metabolism_Homo sapiens_hsa005911.54654879
15Arachidonic acid metabolism_Homo sapiens_hsa005901.28468799
16Glutathione metabolism_Homo sapiens_hsa004801.23782818
17Thyroid hormone synthesis_Homo sapiens_hsa049181.12233799
18Vitamin B6 metabolism_Homo sapiens_hsa007501.08066824
19Primary bile acid biosynthesis_Homo sapiens_hsa001201.06437137
20Ether lipid metabolism_Homo sapiens_hsa005651.03984761
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.03303331
22Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.01679309
23Influenza A_Homo sapiens_hsa051640.99144227
24Carbohydrate digestion and absorption_Homo sapiens_hsa049730.94355033
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87423269
26Sulfur relay system_Homo sapiens_hsa041220.85397617
27Steroid biosynthesis_Homo sapiens_hsa001000.82650587
28Chemical carcinogenesis_Homo sapiens_hsa052040.68930223
29Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68183598
30Protein export_Homo sapiens_hsa030600.67948556
31Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.67928176
32Complement and coagulation cascades_Homo sapiens_hsa046100.63505964
33Retinol metabolism_Homo sapiens_hsa008300.62993156
34Steroid hormone biosynthesis_Homo sapiens_hsa001400.62172921
35Tight junction_Homo sapiens_hsa045300.58195729
36Proteasome_Homo sapiens_hsa030500.56814248
37Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55366943
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.54242249
39Fatty acid elongation_Homo sapiens_hsa000620.52072568
40Pentose phosphate pathway_Homo sapiens_hsa000300.51611721
41Vibrio cholerae infection_Homo sapiens_hsa051100.48867299
42Circadian rhythm_Homo sapiens_hsa047100.48220323
43Hepatitis C_Homo sapiens_hsa051600.48080437
44Bile secretion_Homo sapiens_hsa049760.42206590
45Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.42125058
46Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.41830210
47Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.40244798
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.39734271
49Ovarian steroidogenesis_Homo sapiens_hsa049130.37715787
50N-Glycan biosynthesis_Homo sapiens_hsa005100.34699404
51Peroxisome_Homo sapiens_hsa041460.33890697
52Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.32965190
53Metabolic pathways_Homo sapiens_hsa011000.32730559
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30101071
55Phototransduction_Homo sapiens_hsa047440.27465446
56Mineral absorption_Homo sapiens_hsa049780.25658546
57Glycerophospholipid metabolism_Homo sapiens_hsa005640.25136931
58Regulation of autophagy_Homo sapiens_hsa041400.23976782
59Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.23764933
60Lysosome_Homo sapiens_hsa041420.23656009
61Selenocompound metabolism_Homo sapiens_hsa004500.23350629
62Fatty acid degradation_Homo sapiens_hsa000710.23134237
63Tryptophan metabolism_Homo sapiens_hsa003800.21727541
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.20911284
65Sphingolipid metabolism_Homo sapiens_hsa006000.20664950
66Legionellosis_Homo sapiens_hsa051340.19640993
67Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.19498598
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.18358585
69Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.15835544
70Notch signaling pathway_Homo sapiens_hsa043300.15177910
71Glycosaminoglycan degradation_Homo sapiens_hsa005310.14720230
72Butanoate metabolism_Homo sapiens_hsa006500.13972263
73Folate biosynthesis_Homo sapiens_hsa007900.12820298
74Fructose and mannose metabolism_Homo sapiens_hsa000510.12056889
75Galactose metabolism_Homo sapiens_hsa000520.10531601
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.08474607
77Leukocyte transendothelial migration_Homo sapiens_hsa046700.08324602
78TGF-beta signaling pathway_Homo sapiens_hsa043500.07740501
79Oxidative phosphorylation_Homo sapiens_hsa001900.05174653
80Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.05048623
81Histidine metabolism_Homo sapiens_hsa003400.04131596
82Arginine and proline metabolism_Homo sapiens_hsa003300.03683270
83Collecting duct acid secretion_Homo sapiens_hsa049660.03272892
84Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.02647697
85Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.01730764
86beta-Alanine metabolism_Homo sapiens_hsa004100.00521367
87Adherens junction_Homo sapiens_hsa04520-0.0744954
88Vascular smooth muscle contraction_Homo sapiens_hsa04270-0.0617432
89HIF-1 signaling pathway_Homo sapiens_hsa04066-0.0570360
90Caffeine metabolism_Homo sapiens_hsa00232-0.0503869
91Pyruvate metabolism_Homo sapiens_hsa00620-0.0420857
92Other glycan degradation_Homo sapiens_hsa00511-0.0388973
93Propanoate metabolism_Homo sapiens_hsa00640-0.0335248
94RNA polymerase_Homo sapiens_hsa03020-0.0262579
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760-0.0247804
96Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964-0.0215014
97Insulin secretion_Homo sapiens_hsa04911-0.0106652
98Jak-STAT signaling pathway_Homo sapiens_hsa04630-0.0097396
992-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210-0.0078728
100Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623-0.0021727

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