CTRC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase S1 family. The encoded protein is a serum calcium-decreasing factor that has chymotrypsin-like protease activity. Alternatively spliced transcript variants have been observed, but their full-length nature has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1exocrine pancreas development (GO:0031017)8.75873269
2digestion (GO:0007586)8.02118490
3negative regulation of epidermal cell differentiation (GO:0045605)7.17708483
4protein retention in ER lumen (GO:0006621)6.53911842
5nuclear pore complex assembly (GO:0051292)6.47531396
6regulation of posttranscriptional gene silencing (GO:0060147)6.41487491
7regulation of gene silencing by miRNA (GO:0060964)6.41487491
8regulation of gene silencing by RNA (GO:0060966)6.41487491
9regulation of helicase activity (GO:0051095)6.21949019
10maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.19587648
11nuclear pore organization (GO:0006999)6.08178070
12phosphatidylinositol acyl-chain remodeling (GO:0036149)6.06417509
13regulation of protein polyubiquitination (GO:1902914)5.74116412
14phosphatidylserine acyl-chain remodeling (GO:0036150)5.54327579
15negative regulation of DNA repair (GO:0045738)5.37735492
16negative regulation of epidermis development (GO:0045683)5.33898222
17regulation of histone H3-K9 methylation (GO:0051570)5.16003576
18regulation of gene silencing (GO:0060968)4.99110406
19pre-miRNA processing (GO:0031054)4.92394127
20nephron epithelium morphogenesis (GO:0072088)4.82155350
21nephron tubule morphogenesis (GO:0072078)4.82155350
22pore complex assembly (GO:0046931)4.80462635
23intestinal absorption (GO:0050892)4.72558348
24phosphatidylglycerol acyl-chain remodeling (GO:0036148)4.67315943
25negative regulation of mesenchymal cell apoptotic process (GO:2001054)4.61123115
26transcytosis (GO:0045056)4.56030163
27somatic diversification of immune receptors via somatic mutation (GO:0002566)4.55002457
28somatic hypermutation of immunoglobulin genes (GO:0016446)4.55002457
29negative regulation of histone methylation (GO:0031061)4.54715513
30regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.51881049
31determination of adult lifespan (GO:0008340)4.50859512
32phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.50669200
33phospholipid catabolic process (GO:0009395)4.49799784
34negative regulation of chromatin modification (GO:1903309)4.40183285
35DNA replication-dependent nucleosome organization (GO:0034723)4.36645862
36DNA replication-dependent nucleosome assembly (GO:0006335)4.36645862
37cobalamin metabolic process (GO:0009235)4.29392185
38neuron fate determination (GO:0048664)4.27259346
39ceramide catabolic process (GO:0046514)4.22118238
40negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.18542349
41negative regulation of translation, ncRNA-mediated (GO:0040033)4.18542349
42regulation of translation, ncRNA-mediated (GO:0045974)4.18542349
43auditory receptor cell differentiation (GO:0042491)4.18423883
44cholesterol catabolic process (GO:0006707)4.12927652
45sterol catabolic process (GO:0016127)4.12927652
46neutrophil mediated immunity (GO:0002446)4.05086193
47negative regulation of digestive system process (GO:0060457)3.99030152
48intestinal epithelial cell development (GO:0060576)3.94675235
49folic acid-containing compound biosynthetic process (GO:0009396)3.91917653
50regulation of chromatin silencing (GO:0031935)3.88630719
51DNA unwinding involved in DNA replication (GO:0006268)3.83979007
52ncRNA catabolic process (GO:0034661)3.83477315
53polyketide metabolic process (GO:0030638)3.80496431
54doxorubicin metabolic process (GO:0044598)3.80496431
55daunorubicin metabolic process (GO:0044597)3.80496431
56peptidyl-proline hydroxylation (GO:0019511)3.77443499
57mitotic sister chromatid cohesion (GO:0007064)3.77135679
58histone H2A monoubiquitination (GO:0035518)3.76843238
59phosphatidylcholine acyl-chain remodeling (GO:0036151)3.74555696
60heterochromatin organization (GO:0070828)3.71897985
61negative regulation of histone modification (GO:0031057)3.70326709
62IMP biosynthetic process (GO:0006188)3.69210215
63water-soluble vitamin biosynthetic process (GO:0042364)3.69109548
64L-fucose catabolic process (GO:0042355)3.66488565
65fucose catabolic process (GO:0019317)3.66488565
66L-fucose metabolic process (GO:0042354)3.66488565
67negative regulation of DNA recombination (GO:0045910)3.64938815
68axon ensheathment in central nervous system (GO:0032291)3.63359658
69central nervous system myelination (GO:0022010)3.63359658
70regulation of keratinocyte proliferation (GO:0010837)3.61955765
71tetrapyrrole metabolic process (GO:0033013)3.60172029
72behavioral response to nicotine (GO:0035095)3.59227260
73chromatin assembly (GO:0031497)3.58231607
74regulation of phospholipase A2 activity (GO:0032429)3.56658117
75glutamine metabolic process (GO:0006541)3.54638265
76digestive system process (GO:0022600)3.54595670
77regulation of DNA methylation (GO:0044030)3.54481898
78macroautophagy (GO:0016236)3.53926626
79regulation of mesenchymal cell apoptotic process (GO:2001053)3.48027010
80IMP metabolic process (GO:0046040)3.47456407
81DNA duplex unwinding (GO:0032508)3.46039106
82DNA geometric change (GO:0032392)3.45908894
83DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.45746520
84cysteine metabolic process (GO:0006534)3.45292095
85fatty acid derivative transport (GO:1901571)3.45167908
86icosanoid transport (GO:0071715)3.45167908
87aminoglycoside antibiotic metabolic process (GO:0030647)3.44164485
88negative regulation of gene silencing (GO:0060969)3.43760022
89regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.42785383
90regulation of mitotic spindle checkpoint (GO:1903504)3.42785383
91renal tubule morphogenesis (GO:0061333)3.41157746
92regulation of RNA export from nucleus (GO:0046831)3.32542773
93negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.26649822
94regulation of centriole replication (GO:0046599)3.24610777
95water-soluble vitamin metabolic process (GO:0006767)3.24218595
96valine metabolic process (GO:0006573)3.23762528
97S-adenosylmethionine metabolic process (GO:0046500)3.23363118
98regulation of translation in response to stress (GO:0043555)3.21751348
99mitochondrial calcium ion transport (GO:0006851)3.21398015
100neuronal stem cell maintenance (GO:0097150)3.21240758
101negative regulation of oligodendrocyte differentiation (GO:0048715)3.20517990
102positive regulation of histone methylation (GO:0031062)3.20205692
103phosphatidylserine metabolic process (GO:0006658)3.17397740
104regulation of microtubule-based movement (GO:0060632)3.17364671
105paraxial mesoderm development (GO:0048339)3.16905205
106protein K6-linked ubiquitination (GO:0085020)3.15648715
107glycolipid catabolic process (GO:0019377)3.13703142
108radial glial cell differentiation (GO:0060019)3.13182759
109sterol transport (GO:0015918)3.12663334
110cholesterol transport (GO:0030301)3.12663334
111establishment of apical/basal cell polarity (GO:0035089)3.10974105
112kinetochore organization (GO:0051383)3.07668928
113regulation of gene expression by genetic imprinting (GO:0006349)3.04251920
114mitotic nuclear envelope disassembly (GO:0007077)3.03088657
115positive regulation of histone H3-K4 methylation (GO:0051571)3.01282300
116COPI coating of Golgi vesicle (GO:0048205)3.01130447
117Golgi transport vesicle coating (GO:0048200)3.01130447
118otic vesicle formation (GO:0030916)3.00158190
119membrane lipid catabolic process (GO:0046466)2.99425053
120regulation of centrosome duplication (GO:0010824)2.98382178
121regulation of histone H3-K27 methylation (GO:0061085)2.98366659
122antibacterial humoral response (GO:0019731)2.97956332
123positive regulation of gene expression, epigenetic (GO:0045815)2.97841987
124multicellular organism reproduction (GO:0032504)2.94606722
125regulation of translational termination (GO:0006449)2.93904717
126negative regulation of peptidyl-lysine acetylation (GO:2000757)2.93079925
127serine family amino acid biosynthetic process (GO:0009070)2.92871456
128tetrahydrofolate metabolic process (GO:0046653)2.92698527
129regulation of mitotic spindle organization (GO:0060236)2.92392476
130nephron tubule formation (GO:0072079)2.91265708
131dosage compensation (GO:0007549)2.90453619
132nuclear envelope disassembly (GO:0051081)2.89450305
133membrane disassembly (GO:0030397)2.89450305
134negative regulation of inclusion body assembly (GO:0090084)2.89194530
135antimicrobial humoral response (GO:0019730)2.88460372
136protein hydroxylation (GO:0018126)2.88216448
137nonmotile primary cilium assembly (GO:0035058)2.87879798
138chromatin silencing (GO:0006342)2.87792386
139DNA damage response, signal transduction resulting in transcription (GO:0042772)2.87290955
140icosanoid secretion (GO:0032309)2.87042744
141arachidonic acid secretion (GO:0050482)2.87042744
142regulation of translational fidelity (GO:0006450)2.86698467
143detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.86137669
144pteridine-containing compound biosynthetic process (GO:0042559)2.85894150
145branched-chain amino acid catabolic process (GO:0009083)2.85515168
146regulation of centrosome cycle (GO:0046605)2.85476062
147DNA demethylation (GO:0080111)2.84620026
148chromatin remodeling at centromere (GO:0031055)2.84120737
149negative regulation of astrocyte differentiation (GO:0048712)2.83995872
150myeloid leukocyte mediated immunity (GO:0002444)2.81993031
151mannosylation (GO:0097502)2.80515723
152antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.80154294
153limb bud formation (GO:0060174)2.79952264
154negative regulation of chromosome organization (GO:2001251)2.79518484
155leukotriene biosynthetic process (GO:0019370)2.77311191
156protein refolding (GO:0042026)2.76218604
157astrocyte differentiation (GO:0048708)2.74781994
158preassembly of GPI anchor in ER membrane (GO:0016254)2.74736722
159endocrine pancreas development (GO:0031018)2.74266470
160innate immune response in mucosa (GO:0002227)2.73135407
161regulation of keratinocyte differentiation (GO:0045616)2.67017686
162negative regulation of epithelial cell differentiation (GO:0030857)2.66777010
163rRNA catabolic process (GO:0016075)2.65427748
164pattern specification involved in kidney development (GO:0061004)2.65262173
165phototransduction, visible light (GO:0007603)2.65022858
166sphingolipid catabolic process (GO:0030149)2.61131743
167cellular protein catabolic process (GO:0044257)2.61036551
168vitamin metabolic process (GO:0006766)2.58429018
169cellular ketone body metabolic process (GO:0046950)2.54758983
170mucosal immune response (GO:0002385)2.52804425
171detection of visible light (GO:0009584)2.51606547
172regulation of male gonad development (GO:2000018)2.50836180
173regulation of acrosome reaction (GO:0060046)2.50083123
174alditol phosphate metabolic process (GO:0052646)2.49362869
175phosphatidylglycerol metabolic process (GO:0046471)2.44263364
176tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.44263037
177RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.44263037
178quinone metabolic process (GO:1901661)2.43836117
179neuronal action potential (GO:0019228)2.38829424
180phototransduction (GO:0007602)2.38607006
181rhodopsin mediated signaling pathway (GO:0016056)2.38504063
182positive regulation of male gonad development (GO:2000020)2.38345396
183endocardial cushion morphogenesis (GO:0003203)2.37736262
184response to pheromone (GO:0019236)2.37492988
185intestinal cholesterol absorption (GO:0030299)11.0202453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse9.25842277
2VDR_22108803_ChIP-Seq_LS180_Human3.36746266
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.31590013
4SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.24785052
5FOXM1_23109430_ChIP-Seq_U2OS_Human3.23103397
6ZNF274_21170338_ChIP-Seq_K562_Hela3.09324390
7KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.97681280
8KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.97681280
9KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.97681280
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.89596242
11KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.82170392
12TAF15_26573619_Chip-Seq_HEK293_Human2.71292814
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.70650861
14POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.68389426
15GBX2_23144817_ChIP-Seq_PC3_Human2.47741033
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.36024463
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35711528
18SOX2_18555785_ChIP-Seq_MESCs_Mouse2.19847629
19E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.06776395
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.04566587
21ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02539474
22CTBP1_25329375_ChIP-Seq_LNCAP_Human2.02463895
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.00040533
24E2F7_22180533_ChIP-Seq_HELA_Human10.3117737
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.97818764
26NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.89520287
27EZH2_22144423_ChIP-Seq_EOC_Human1.89300818
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.88100928
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.84900242
30P300_19829295_ChIP-Seq_ESCs_Human1.83674931
31NELFA_20434984_ChIP-Seq_ESCs_Mouse1.82169402
32PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.79129398
33MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.78956815
34AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.78350061
35FUS_26573619_Chip-Seq_HEK293_Human1.70818558
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70739707
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.67712225
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67081863
39TCF3_18692474_ChIP-Seq_MEFs_Mouse1.66414099
40GATA4_25053715_ChIP-Seq_YYC3_Human1.65985815
41RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.65548355
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.65373254
43TCF3_18692474_ChIP-Seq_MESCs_Mouse1.63856505
44SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.63697585
45NR3C1_21868756_ChIP-Seq_MCF10A_Human1.63102112
46SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62131106
47SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.59304876
48EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.59249177
49ER_23166858_ChIP-Seq_MCF-7_Human1.58522872
50* FOXA1_27270436_Chip-Seq_PROSTATE_Human1.58030283
51* FOXA1_25329375_ChIP-Seq_VCAP_Human1.58030283
52SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.56919497
53EWS_26573619_Chip-Seq_HEK293_Human1.56318924
54FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55349569
55NANOG_18555785_ChIP-Seq_MESCs_Mouse1.52074594
56EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49248488
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.48782582
58MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47089899
59TAF2_19829295_ChIP-Seq_ESCs_Human1.45337249
60POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.44522129
61GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44376397
62POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.43621729
63IGF1R_20145208_ChIP-Seq_DFB_Human1.41923356
64TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.41707160
65REST_21632747_ChIP-Seq_MESCs_Mouse1.41645787
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.40658097
67FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.38302601
68ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37949094
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.37506745
70MYC_18940864_ChIP-ChIP_HL60_Human1.37344072
71CBP_20019798_ChIP-Seq_JUKART_Human1.36174970
72IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.36174970
73AR_25329375_ChIP-Seq_VCAP_Human1.36023759
74ETV2_25802403_ChIP-Seq_MESCs_Mouse1.33642296
75PIAS1_25552417_ChIP-Seq_VCAP_Human1.33509587
76FOXA1_21572438_ChIP-Seq_LNCaP_Human1.32262293
77TP53_22573176_ChIP-Seq_HFKS_Human1.32111439
78UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31236003
79STAT3_23295773_ChIP-Seq_U87_Human1.30805965
80NOTCH1_21737748_ChIP-Seq_TLL_Human1.30399669
81NANOG_19829295_ChIP-Seq_ESCs_Human1.29226038
82SOX2_19829295_ChIP-Seq_ESCs_Human1.29226038
83MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.27453504
84* ETV1_20927104_ChIP-Seq_GIST48_Human1.26930873
85SMAD4_21741376_ChIP-Seq_EPCs_Human1.25568535
86* PHF8_20622853_ChIP-Seq_HELA_Human1.24917325
87NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.24488635
88CBX2_27304074_Chip-Seq_ESCs_Mouse1.24008059
89GATA3_21878914_ChIP-Seq_MCF-7_Human1.23963775
90MYC_18358816_ChIP-ChIP_MESCs_Mouse1.23579489
91HTT_18923047_ChIP-ChIP_STHdh_Human1.23462953
92AR_20517297_ChIP-Seq_VCAP_Human1.22512086
93MYC_19829295_ChIP-Seq_ESCs_Human1.21086484
94KLF5_20875108_ChIP-Seq_MESCs_Mouse1.20379313
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19843984
96SOX2_18692474_ChIP-Seq_MESCs_Mouse1.19404200
97NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18857170
98TCF4_18268006_ChIP-ChIP_LS174T_Human1.18265088
99RNF2_27304074_Chip-Seq_NSC_Mouse1.17775108
100AR_21909140_ChIP-Seq_LNCAP_Human1.17714434
101* HOXB7_26014856_ChIP-Seq_BT474_Human1.17572352
102KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.16569497
103BCAT_22108803_ChIP-Seq_LS180_Human1.16487643
104NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16101146
105BMI1_23680149_ChIP-Seq_NPCS_Mouse1.15612605
106PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15390362
107BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.14801328
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.14322849
109CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.14289300
110ELK1_19687146_ChIP-ChIP_HELA_Human1.13501108
111NANOG_21062744_ChIP-ChIP_HESCs_Human1.12785772
112E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11624249
113ERA_21632823_ChIP-Seq_H3396_Human1.10731384
114* NFYA_21822215_ChIP-Seq_K562_Human1.10682533
115* PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.09753779
116* HNFA_21074721_ChIP-Seq_CACO-2_Human1.09732419
117TCF4_22108803_ChIP-Seq_LS180_Human1.09331887
118TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08947423
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.08829385
120CDX2_22108803_ChIP-Seq_LS180_Human1.08346630
121RUNX2_22187159_ChIP-Seq_PCA_Human1.08290462
122TCF4_23295773_ChIP-Seq_U87_Human1.08265545
123CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.07939434
124SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06530851
125* NFYB_21822215_ChIP-Seq_K562_Human1.06494855
126* RBPJ_21746931_ChIP-Seq_IB4_Human1.06452088
127EED_16625203_ChIP-ChIP_MESCs_Mouse1.06304054
128SMAD4_21799915_ChIP-Seq_A2780_Human1.06027746
129POU5F1_16153702_ChIP-ChIP_HESCs_Human1.04837895
130AUTS2_25519132_ChIP-Seq_293T-REX_Human1.04744352
131PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.04519174
132MYC_22102868_ChIP-Seq_BL_Human1.04510325
133CEBPB_22108803_ChIP-Seq_LS180_Human1.04486529
134IRF8_22096565_ChIP-ChIP_GC-B_Human1.03609822
135VDR_23849224_ChIP-Seq_CD4+_Human1.03225337
136FOXH1_21741376_ChIP-Seq_EPCs_Human1.03094813
137NANOG_18692474_ChIP-Seq_MESCs_Mouse1.02880159
138TP53_16413492_ChIP-PET_HCT116_Human1.02248683
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.02207319
140* CBX2_22325352_ChIP-Seq_293T-Rex_Human1.01448844
141REST_18959480_ChIP-ChIP_MESCs_Mouse1.01192922
142AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.00748486
143* CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.00222808
144* TBL1_22424771_ChIP-Seq_293T_Human1.00196969
145* GATA6_21074721_ChIP-Seq_CACO-2_Human0.99903041
146EGR1_23403033_ChIP-Seq_LIVER_Mouse0.99748992
147NCOR_22424771_ChIP-Seq_293T_Human0.99473460
148ZFX_18555785_ChIP-Seq_MESCs_Mouse0.98657065
149NANOG_18692474_ChIP-Seq_MEFs_Mouse0.98368170
150IRF1_19129219_ChIP-ChIP_H3396_Human0.97439618
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96922991
152SOX2_16153702_ChIP-ChIP_HESCs_Human0.96179581
153PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96072691
154TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95410033
155YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.95375062
156SOX2_18692474_ChIP-Seq_MEFs_Mouse0.95052610
157POU5F1_16518401_ChIP-PET_MESCs_Mouse0.93815993
158ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93118123
159ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91667752
160XRN2_22483619_ChIP-Seq_HELA_Human0.90404669
161KDM5A_27292631_Chip-Seq_BREAST_Human0.90386899
162HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89920987
163KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89345272
164CHD1_26751641_Chip-Seq_LNCaP_Human0.86359166
165POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86262913
166KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85529643
167PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85046911
168NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.84895398
169GATA6_25053715_ChIP-Seq_YYC3_Human0.83283413
170RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.81073511
171GATA1_22025678_ChIP-Seq_K562_Human0.80830790
172KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.80661720
173ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.80295189
174CREB1_15753290_ChIP-ChIP_HEK293T_Human0.79821286
175NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79436855
176PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.78914689
177TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78652974
178IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.78538612
179NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.77635841
180TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.77531885
181TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.77085928
182GATA1_26923725_Chip-Seq_HPCs_Mouse0.76942155
183NANOG_16518401_ChIP-PET_MESCs_Mouse0.76535155
184FOXP3_21729870_ChIP-Seq_TREG_Human0.76249233
185ETS1_20019798_ChIP-Seq_JURKAT_Human0.76099951
186ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.74759862
187ESR1_21235772_ChIP-Seq_MCF-7_Human0.74737639
188PADI4_21655091_ChIP-ChIP_MCF-7_Human0.73865837
189SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.73448073
190KAP1_27257070_Chip-Seq_ESCs_Mouse0.72664960
191SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.72353167
192NANOG_16153702_ChIP-ChIP_HESCs_Human0.71889616

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract7.18326257
2MP0001666_abnormal_nutrient_absorption6.66878574
3MP0005365_abnormal_bile_salt4.59656599
4MP0005220_abnormal_exocrine_pancreas4.35366950
5MP0003868_abnormal_feces_composition3.98957139
6MP0003705_abnormal_hypodermis_morpholog3.46331903
7MP0003806_abnormal_nucleotide_metabolis3.06602421
8MP0003123_paternal_imprinting3.04703279
9MP0005085_abnormal_gallbladder_physiolo2.98644225
10MP0010352_gastrointestinal_tract_polyps2.80189357
11MP0010234_abnormal_vibrissa_follicle2.79103912
12MP0005084_abnormal_gallbladder_morpholo2.75614297
13MP0004885_abnormal_endolymph2.62747789
14MP0003693_abnormal_embryo_hatching2.62078239
15MP0008057_abnormal_DNA_replication2.58207832
16MP0010094_abnormal_chromosome_stability2.50304721
17MP0010307_abnormal_tumor_latency2.34156049
18MP0003195_calcinosis2.32301722
19MP0003111_abnormal_nucleus_morphology2.24357496
20MP0001485_abnormal_pinna_reflex2.17397838
21MP0004957_abnormal_blastocyst_morpholog2.16978179
22MP0009384_cardiac_valve_regurgitation2.07934540
23MP0003077_abnormal_cell_cycle2.02673335
24MP0002638_abnormal_pupillary_reflex2.01900117
25MP0006072_abnormal_retinal_apoptosis2.00862161
26MP0002693_abnormal_pancreas_physiology1.99509609
27MP0002138_abnormal_hepatobiliary_system1.88314949
28MP0002736_abnormal_nociception_after1.72125323
29MP0000490_abnormal_crypts_of1.72079303
30MP0004742_abnormal_vestibular_system1.71770557
31MP0010386_abnormal_urinary_bladder1.69894658
32MP0002102_abnormal_ear_morphology1.69210883
33MP0003121_genomic_imprinting1.68904216
34MP0008872_abnormal_physiological_respon1.65933611
35MP0000350_abnormal_cell_proliferation1.64438120
36MP0002876_abnormal_thyroid_physiology1.64375812
37MP0001968_abnormal_touch/_nociception1.58101461
38MP0005253_abnormal_eye_physiology1.57120630
39MP0004264_abnormal_extraembryonic_tissu1.51193792
40MP0005551_abnormal_eye_electrophysiolog1.50845742
41MP0003566_abnormal_cell_adhesion1.48357697
42MP0005623_abnormal_meninges_morphology1.48213434
43MP0003959_abnormal_lean_body1.44060021
44MP0004197_abnormal_fetal_growth/weight/1.41908260
45MP0002084_abnormal_developmental_patter1.41537188
46MP0005076_abnormal_cell_differentiation1.39788257
47MP0010329_abnormal_lipoprotein_level1.38219637
48MP0001730_embryonic_growth_arrest1.37752679
49MP0008875_abnormal_xenobiotic_pharmacok1.36949154
50MP0008058_abnormal_DNA_repair1.36615758
51MP0002086_abnormal_extraembryonic_tissu1.31551708
52MP0002837_dystrophic_cardiac_calcinosis1.31215451
53MP0005646_abnormal_pituitary_gland1.28610067
54MP0001502_abnormal_circadian_rhythm1.27077655
55MP0002928_abnormal_bile_duct1.27012334
56MP0004142_abnormal_muscle_tone1.23317339
57MP0001664_abnormal_digestion1.21070560
58MP0001984_abnormal_olfaction1.20544775
59MP0005380_embryogenesis_phenotype1.20322620
60MP0001672_abnormal_embryogenesis/_devel1.20322620
61MP0009703_decreased_birth_body1.18485748
62MP0002163_abnormal_gland_morphology1.18361933
63MP0004185_abnormal_adipocyte_glucose1.17630889
64MP0001697_abnormal_embryo_size1.15474077
65MP0002282_abnormal_trachea_morphology1.15428527
66MP0002085_abnormal_embryonic_tissue1.13816500
67MP0003011_delayed_dark_adaptation1.13251291
68MP0004233_abnormal_muscle_weight1.13086779
69MP0004043_abnormal_pH_regulation1.11885677
70MP0004145_abnormal_muscle_electrophysio1.10515057
71MP0009672_abnormal_birth_weight1.09515287
72MP0008007_abnormal_cellular_replicative1.08134468
73MP0002088_abnormal_embryonic_growth/wei1.07877900
74MP0000470_abnormal_stomach_morphology1.07488229
75MP0003984_embryonic_growth_retardation1.07483625
76MP0009745_abnormal_behavioral_response1.05491765
77MP0002272_abnormal_nervous_system1.05032135
78MP0001986_abnormal_taste_sensitivity1.04831908
79MP0005448_abnormal_energy_balance1.04535523
80MP0005452_abnormal_adipose_tissue1.04468701
81MP0001501_abnormal_sleep_pattern1.04181369
82MP0001293_anophthalmia1.03929691
83MP0002080_prenatal_lethality1.01565445
84MP0003119_abnormal_digestive_system1.00615891
85MP0003890_abnormal_embryonic-extraembry1.00323647
86MP0002277_abnormal_respiratory_mucosa1.00290588
87MP0001944_abnormal_pancreas_morphology0.99397556
88MP0001915_intracranial_hemorrhage0.96808756
89MP0000371_diluted_coat_color0.96709381
90MP0001764_abnormal_homeostasis0.96564157
91MP0002653_abnormal_ependyma_morphology0.95660839
92MP0003953_abnormal_hormone_level0.95445702
93MP0003186_abnormal_redox_activity0.95316525
94MP0005377_hearing/vestibular/ear_phenot0.94599851
95MP0003878_abnormal_ear_physiology0.94599851
96MP0002877_abnormal_melanocyte_morpholog0.94201500
97MP0001849_ear_inflammation0.93918613
98MP0005379_endocrine/exocrine_gland_phen0.91226113
99MP0002396_abnormal_hematopoietic_system0.90194674
100MP0000427_abnormal_hair_cycle0.88960354
101MP0000049_abnormal_middle_ear0.87291495
102MP0000749_muscle_degeneration0.87216046
103MP0000631_abnormal_neuroendocrine_gland0.86234875
104MP0003786_premature_aging0.85227619
105MP0005195_abnormal_posterior_eye0.84871591
106MP0002557_abnormal_social/conspecific_i0.84855456
107MP0002938_white_spotting0.84416882
108MP0005266_abnormal_metabolism0.84068604
109MP0000026_abnormal_inner_ear0.81501456
110MP0000313_abnormal_cell_death0.80095538
111MP0000569_abnormal_digit_pigmentation0.80026938
112MP0000538_abnormal_urinary_bladder0.79556737
113MP0003646_muscle_fatigue0.78445695
114MP0001963_abnormal_hearing_physiology0.77654565
115MP0009780_abnormal_chondrocyte_physiolo0.77567229
116MP0008877_abnormal_DNA_methylation0.77534100
117MP0005645_abnormal_hypothalamus_physiol0.76672730
118MP0003943_abnormal_hepatobiliary_system0.75573502
119MP0009046_muscle_twitch0.75190421
120MP0002735_abnormal_chemical_nociception0.73502170
121MP0003638_abnormal_response/metabolism_0.72461995
122MP0002075_abnormal_coat/hair_pigmentati0.72197883
123MP0009765_abnormal_xenobiotic_induced0.71960100
124MP0002139_abnormal_hepatobiliary_system0.70936662
125MP0008995_early_reproductive_senescence0.70804900
126MP0000003_abnormal_adipose_tissue0.70461490
127MP0006276_abnormal_autonomic_nervous0.69520514
128MP0004133_heterotaxia0.68657557
129MP0004147_increased_porphyrin_level0.68367439
130MP0001756_abnormal_urination0.67918355
131MP0001486_abnormal_startle_reflex0.67662778
132MP0002572_abnormal_emotion/affect_behav0.66567335
133MP0002067_abnormal_sensory_capabilities0.65999330
134MP0005165_increased_susceptibility_to0.65956871
135MP0003787_abnormal_imprinting0.65881129
136MP0000230_abnormal_systemic_arterial0.64543423
137MP0005391_vision/eye_phenotype0.64507027
138MP0002733_abnormal_thermal_nociception0.64456517
139MP0003252_abnormal_bile_duct0.64180053
140MP0004019_abnormal_vitamin_homeostasis0.63799514
141MP0001919_abnormal_reproductive_system0.63686019
142MP0002078_abnormal_glucose_homeostasis0.63521596
143MP0009763_increased_sensitivity_to0.61422441
144MP0004924_abnormal_behavior0.61213516
145MP0005386_behavior/neurological_phenoty0.61213516
146MP0005389_reproductive_system_phenotype0.61136737
147MP0002064_seizures0.60957866
148MP0000613_abnormal_salivary_gland0.60799261
149MP0001324_abnormal_eye_pigmentation0.60428550
150MP0005384_cellular_phenotype0.59663211
151MP0003567_abnormal_fetal_cardiomyocyte0.59400155
152MP0005621_abnormal_cell_physiology0.59090486
153MP0002019_abnormal_tumor_incidence0.58768349
154MP0003283_abnormal_digestive_organ0.58444048
155MP0002118_abnormal_lipid_homeostasis0.57864511
156MP0003136_yellow_coat_color0.57701508
157MP0006036_abnormal_mitochondrial_physio0.55202160
158MP0003941_abnormal_skin_development0.54604242
159MP0000598_abnormal_liver_morphology0.54599832
160MP0001348_abnormal_lacrimal_gland0.53004256
161MP0001286_abnormal_eye_development0.52779675
162MP0005023_abnormal_wound_healing0.51530156
163MP0005332_abnormal_amino_acid0.51143808
164MP0001873_stomach_inflammation0.50729401
165MP0001186_pigmentation_phenotype0.48993532
166MP0002111_abnormal_tail_morphology0.47767812
167MP0004808_abnormal_hematopoietic_stem0.47249594
168MP0008770_decreased_survivor_rate0.47164479
169MP0001145_abnormal_male_reproductive0.46501272
170MP0002006_tumorigenesis0.46232865
171MP0006054_spinal_hemorrhage0.45229508
172MP0005375_adipose_tissue_phenotype0.44287037
173MP0002009_preneoplasia0.44069736
174MP0008932_abnormal_embryonic_tissue0.43174350

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)6.34352481
2Agnosia (HP:0010524)5.62026499
3Steatorrhea (HP:0002570)5.26833420
4Short chin (HP:0000331)4.77168217
5Type II lissencephaly (HP:0007260)4.67046150
6Abnormality of the astrocytes (HP:0100707)4.56243370
7Astrocytoma (HP:0009592)4.56243370
8Medulloblastoma (HP:0002885)4.38311664
9Neoplasm of the oral cavity (HP:0100649)4.28412096
10Fat malabsorption (HP:0002630)4.25609378
11True hermaphroditism (HP:0010459)4.19389372
12Biliary tract neoplasm (HP:0100574)4.14425607
13Abnormality of midbrain morphology (HP:0002418)4.07248697
14Molar tooth sign on MRI (HP:0002419)4.07248697
15Tubular atrophy (HP:0000092)4.03488516
16Amaurosis fugax (HP:0100576)3.91565838
17Cerebellar dysplasia (HP:0007033)3.84385604
18Pancreatic cysts (HP:0001737)3.76109201
19Hypoplastic iliac wings (HP:0002866)3.68972710
20Rhabdomyosarcoma (HP:0002859)3.66835080
21Medial flaring of the eyebrow (HP:0010747)3.57633283
22Abnormality of the labia minora (HP:0012880)3.54212896
23Colon cancer (HP:0003003)3.52567980
24Glioma (HP:0009733)3.44688479
25Carpal bone hypoplasia (HP:0001498)3.42521631
26Type I diabetes mellitus (HP:0100651)3.24522665
27Tubulointerstitial nephritis (HP:0001970)3.24120615
28Abnormality of the renal cortex (HP:0011035)3.21750870
29Abnormality of the salivary glands (HP:0010286)3.20954532
30Volvulus (HP:0002580)3.18733921
31Pancreatic fibrosis (HP:0100732)3.11827361
32Congenital stationary night blindness (HP:0007642)3.02374692
33Cortical dysplasia (HP:0002539)3.01841942
34Chromsome breakage (HP:0040012)2.98580027
35Supernumerary spleens (HP:0009799)2.98462502
36Nephronophthisis (HP:0000090)2.95739220
37Polydipsia (HP:0001959)2.87153499
38Abnormal drinking behavior (HP:0030082)2.87153499
39Abnormal sex determination (HP:0012244)2.78951100
40Sex reversal (HP:0012245)2.78951100
41Abnormality of the renal medulla (HP:0100957)2.78230021
42Severe muscular hypotonia (HP:0006829)2.77696189
43Maternal diabetes (HP:0009800)2.73316776
44Spastic diplegia (HP:0001264)2.72362576
45Gait imbalance (HP:0002141)2.70590411
46Mesangial abnormality (HP:0001966)2.70142121
47Congenital primary aphakia (HP:0007707)2.69613789
48Large for gestational age (HP:0001520)2.69580412
49Lissencephaly (HP:0001339)2.69259816
50Abnormality of chromosome stability (HP:0003220)2.68669216
51Gout (HP:0001997)2.68425459
52Chronic hepatic failure (HP:0100626)2.65238501
53Tubulointerstitial fibrosis (HP:0005576)2.57913010
54Nephrogenic diabetes insipidus (HP:0009806)2.57046328
55Chromosomal breakage induced by crosslinking agents (HP:0003221)2.56570351
56Selective tooth agenesis (HP:0001592)2.54800474
57Cystic liver disease (HP:0006706)2.52711558
58Truncal obesity (HP:0001956)2.49782691
59Deviation of the thumb (HP:0009603)2.46663791
60Proximal placement of thumb (HP:0009623)2.45422779
61Abnormal biliary tract morphology (HP:0012440)2.44000183
62Disproportionate short-trunk short stature (HP:0003521)2.43188108
63Decreased subcutaneous fat (HP:0001002)2.43030672
64Esophageal atresia (HP:0002032)2.42576803
65Neoplasm of the small intestine (HP:0100833)2.41404389
66Neoplasm of striated muscle (HP:0009728)2.41042219
67Adenoma sebaceum (HP:0009720)2.40553801
68Angiofibromas (HP:0010615)2.40553801
69Abnormality of the intrinsic pathway (HP:0010989)2.40422711
70Abnormality of subcutaneous fat tissue (HP:0001001)2.40320862
71Neoplasm of the rectum (HP:0100743)2.39998780
72Basal cell carcinoma (HP:0002671)2.38735320
73Morphological abnormality of the middle ear (HP:0008609)2.34852665
74Long foot (HP:0001833)2.28541869
75Intrahepatic cholestasis (HP:0001406)2.26036078
76Hyperglycinemia (HP:0002154)2.25337460
77Delayed puberty (HP:0000823)2.23236591
78Impulsivity (HP:0100710)2.22408090
79Optic nerve hypoplasia (HP:0000609)2.21812325
80Limb hypertonia (HP:0002509)2.21483394
81Sandal gap (HP:0001852)2.21097647
82Male pseudohermaphroditism (HP:0000037)2.20035196
83Missing ribs (HP:0000921)2.19927169
84Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.19540969
85Tubulointerstitial abnormality (HP:0001969)2.19401429
86Ovarian neoplasm (HP:0100615)2.19267255
87Exocrine pancreatic insufficiency (HP:0001738)2.19055299
88Aplasia/Hypoplasia of the sternum (HP:0006714)2.18134141
89Congenital, generalized hypertrichosis (HP:0004540)2.17859451
90Relative macrocephaly (HP:0004482)2.17460709
91Gastrointestinal carcinoma (HP:0002672)2.17188356
92Malignant gastrointestinal tract tumors (HP:0006749)2.17188356
93Morphological abnormality of the inner ear (HP:0011390)2.14314133
94Congenital hepatic fibrosis (HP:0002612)2.13036536
95Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.11158521
96Abnormality of alanine metabolism (HP:0010916)2.11158521
97Hyperalaninemia (HP:0003348)2.11158521
98Hypoalbuminemia (HP:0003073)2.09850360
99Abnormal albumin level (HP:0012116)2.09850360
100Attenuation of retinal blood vessels (HP:0007843)2.07914840
101Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07572376
102Hypoplasia of the pons (HP:0012110)2.07274139
103Polyuria (HP:0000103)2.07229768
104Resting tremor (HP:0002322)2.04942666
105Abnormal respiratory motile cilium morphology (HP:0005938)2.04709627
106Abnormal respiratory epithelium morphology (HP:0012253)2.04709627
107Facial hemangioma (HP:0000329)2.04688040
108Abnormality of monocarboxylic acid metabolism (HP:0010996)2.04025386
109Cafe-au-lait spot (HP:0000957)2.03882249
110Abnormality of methionine metabolism (HP:0010901)2.02238909
111Papillary thyroid carcinoma (HP:0002895)1.99125550
112Genital tract atresia (HP:0001827)1.98230525
113Pancreatitis (HP:0001733)1.96218333
114Vaginal atresia (HP:0000148)1.95910889
115Abnormality of endocrine pancreas physiology (HP:0012093)1.95440686
116Abnormality of the pancreatic islet cells (HP:0006476)1.95440686
117Abnormality of sulfur amino acid metabolism (HP:0004339)1.94842863
118Abnormality of the wing of the ilium (HP:0011867)1.93311303
119Poor coordination (HP:0002370)1.93164786
120Abnormality of the pons (HP:0007361)1.92403194
121Progressive microcephaly (HP:0000253)1.91428755
122Prominent nose (HP:0000448)1.90222319
123Abnormality of the lower motor neuron (HP:0002366)1.89861910
124Absent/shortened dynein arms (HP:0200106)1.88199803
125Dynein arm defect of respiratory motile cilia (HP:0012255)1.88199803
126Short humerus (HP:0005792)1.88197702
127Genetic anticipation (HP:0003743)1.87866140
128Azoospermia (HP:0000027)1.87777545
129Neoplasm of the pancreas (HP:0002894)1.86012657
130Ankyloglossia (HP:0010296)1.85901950
131Decreased electroretinogram (ERG) amplitude (HP:0000654)1.85595053
132Pendular nystagmus (HP:0012043)1.85281385
133Anal atresia (HP:0002023)1.85088241
134Sclerocornea (HP:0000647)1.84754338
135Abnormality of the pleura (HP:0002103)1.84578536
136Methylmalonic acidemia (HP:0002912)1.84177863
137Uterine neoplasm (HP:0010784)1.84070518
138Macroorchidism (HP:0000053)1.83431793
139Abnormal pancreas size (HP:0012094)1.82799624
140Abnormal ciliary motility (HP:0012262)1.81950997
141Neoplasm of the colon (HP:0100273)1.81946267
142Stenosis of the external auditory canal (HP:0000402)1.81721349
143Abnormal rod and cone electroretinograms (HP:0008323)1.81593574
144Enlarged penis (HP:0000040)1.81343531
145Hypoproteinemia (HP:0003075)1.80652949
146Progressive cerebellar ataxia (HP:0002073)1.79621455
147Hypomagnesemia (HP:0002917)1.78700287
148Upper motor neuron abnormality (HP:0002127)1.78456486
149Tachypnea (HP:0002789)1.78414352
150Inability to walk (HP:0002540)1.77035229
151Hypoplasia of the thymus (HP:0000778)1.77012340
152Abolished electroretinogram (ERG) (HP:0000550)1.76813200
153Renal cortical cysts (HP:0000803)1.76726569
154Hypochromic microcytic anemia (HP:0004840)1.76429372
155Hyperglycinuria (HP:0003108)1.75928802
156Furrowed tongue (HP:0000221)1.74138844
157Vertebral clefting (HP:0008428)1.73839851
158Neoplasm of the adrenal cortex (HP:0100641)1.72335859
159Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.72186395
160Hypoplastic ilia (HP:0000946)1.72058365
161Chorioretinal atrophy (HP:0000533)1.71753844
162Hyperventilation (HP:0002883)1.71429301
163Abnormality of the renal collecting system (HP:0004742)1.71169078
164Reticulocytopenia (HP:0001896)1.69920827
165Aplasia/hypoplasia of the humerus (HP:0006507)1.69179039
166Abnormality of renal excretion (HP:0011036)1.68294372
167Protruding tongue (HP:0010808)1.68241491
168Intestinal polyposis (HP:0200008)1.68169904
169Methylmalonic aciduria (HP:0012120)1.66967962
170Anencephaly (HP:0002323)1.65612975
171Myelodysplasia (HP:0002863)1.65483123
172Increased CSF lactate (HP:0002490)1.65139929
173Hypoglycemic seizures (HP:0002173)1.64605933
174Small epiphyses (HP:0010585)1.63476393
175Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.63379288
176Hydroxyprolinuria (HP:0003080)1.63042294
177Abnormality of proline metabolism (HP:0010907)1.63042294
178Gaze-evoked nystagmus (HP:0000640)1.62953645
179Progressive inability to walk (HP:0002505)1.61789486
18011 pairs of ribs (HP:0000878)1.60670234
181Neuroblastic tumors (HP:0004376)1.60374869
182Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.60374869
183Primitive neuroectodermal tumor (HP:0030065)1.60374869
184Fibular hypoplasia (HP:0003038)1.60149025
185Abnormal urine output (HP:0012590)1.60026244
186Duplicated collecting system (HP:0000081)1.56359580
187Abnormality of urine glucose concentration (HP:0011016)1.54955384
188Glycosuria (HP:0003076)1.54955384
189Epiphyseal dysplasia (HP:0002656)1.54828800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1IRAK16.35671153
2CDK125.73262854
3BCKDK5.21144588
4SCYL24.46444288
5EIF2AK34.20394536
6PKN23.50493210
7TLK13.21875893
8PNCK3.11094394
9FLT33.04273968
10WNK42.77768063
11GRK12.75827428
12ZAK2.69093323
13DAPK22.66651177
14CDC72.59228512
15SRPK12.56202623
16LMTK22.52830885
17ADRBK22.44904079
18MAPK152.44357274
19STK392.44346084
20BRD42.17191510
21FRK2.14535084
22BMPR1B2.12946624
23WNK31.99045534
24MAP4K21.97368476
25TIE11.95057952
26MAPKAPK51.88990637
27MAP2K21.83673020
28RPS6KB21.78648674
29OXSR11.59969552
30EIF2AK11.43857791
31AURKB1.39534487
32NME11.39026754
33CASK1.37679134
34ATR1.32231947
35ERN11.31742351
36ATM1.31572915
37WEE11.29920193
38CAMK1D1.29689318
39CHEK21.27682636
40MKNK21.26653016
41STK41.24652575
42EPHA21.24119814
43MET1.21417178
44NTRK31.21327639
45NEK11.20866285
46TTK1.20199834
47PLK11.16710572
48CHEK11.16103211
49TSSK61.14538940
50PINK11.12409813
51PLK31.11733529
52BRSK21.09637696
53VRK11.06219621
54CDK41.04904149
55MAPK131.04771279
56NUAK11.04639853
57CSNK1D1.03843749
58PAK21.02988674
59CAMKK21.02218462
60LATS11.01221120
61PTK2B0.99359210
62NLK0.98502392
63TRPM70.95568912
64PIM10.91087528
65NEK60.90070419
66MAP3K80.88021536
67MKNK10.87499563
68ADRBK10.86374290
69CDK20.86367464
70MAP3K40.85697942
71PDK20.81734211
72PRKCG0.81379044
73MTOR0.80841473
74RPS6KA50.79878384
75ERBB40.79810814
76TXK0.78763869
77CDK70.76162900
78ZAP700.74573121
79PRKCE0.74351704
80ALK0.73213029
81EEF2K0.73059151
82RPS6KB10.70877914
83PRKDC0.67889819
84FGFR20.63975860
85AKT30.62824212
86CDK30.62779579
87DYRK20.62748828
88PDGFRB0.62209996
89NEK20.60374058
90CDK10.60137013
91TEC0.57954842
92TAOK30.57879118
93MAP3K110.57695905
94TTN0.57630988
95PDK30.57480378
96PDK40.57480378
97CSNK2A20.57321984
98EGFR0.57105405
99MAPK140.55402134
100NME20.54586173
101INSRR0.54170741
102DYRK30.53952740
103STK30.53268584
104DYRK1A0.51373530
105RIPK10.50318732
106PRKCI0.50079328
107PAK30.50077188
108EIF2AK20.50075940
109MST40.48417702
110STK110.47940707
111EPHA30.47938729
112TESK10.47758646
113KIT0.47087061
114MAP3K20.46811305
115MAPK10.46777082
116MAPKAPK30.45834834
117RET0.44720027
118PHKG10.44665153
119PHKG20.44665153
120CSNK1E0.44378473
121CDK90.44336430
122IKBKB0.42946115
123TNIK0.42925879
124AKT10.42923140
125MAP2K10.42688743
126BCR0.41194753
127GSK3B0.41124603
128AKT20.40165115
129PIK3CA0.39703888
130CSNK1G20.39277793
131TGFBR10.39223370
132FGFR10.38879389
133CSNK1G10.38526644
134MUSK0.38400278
135STK100.38086888
136AURKA0.37641858
137ROCK10.37560274
138ACVR1B0.36924871
139PTK60.35682577
140MAP3K90.35447814
141ABL10.35023892
142PRKCQ0.34376448
143PRKACA0.33624238
144MAP2K60.32670641
145PRKAA10.31925129
146CHUK0.30599231
147ERBB20.30474163
148MAP3K30.30371505
149PASK0.29971165
150PRKACB0.29244790
151CDK190.27724223
152CDK60.26910760
153STK160.26426311
154DAPK30.25940979
155MELK0.25648807
156CSNK1G30.24738424
157RPS6KA30.24627930
158FGFR30.24211121
159MAP3K140.23846605
160MAP2K70.23684792
161PRKG20.23454444
162ERBB30.23231162
163MARK10.21989448
164PRKCA0.20693098
165CAMK2A0.20467198
166LATS20.20392511
167CAMKK10.18584343
168BRSK10.15682557
169PKN10.15406681
170PRKG10.15138992

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049726.53308277
2Fat digestion and absorption_Homo sapiens_hsa049754.52452473
3Protein digestion and absorption_Homo sapiens_hsa049744.31814787
4Systemic lupus erythematosus_Homo sapiens_hsa053223.88414805
5One carbon pool by folate_Homo sapiens_hsa006703.07169783
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.93075122
7Mismatch repair_Homo sapiens_hsa034302.85127585
8Maturity onset diabetes of the young_Homo sapiens_hsa049502.55779849
9Folate biosynthesis_Homo sapiens_hsa007902.25362792
10Ether lipid metabolism_Homo sapiens_hsa005652.10745812
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09623827
12Protein export_Homo sapiens_hsa030602.06357668
13RNA transport_Homo sapiens_hsa030132.05771674
14Glycerolipid metabolism_Homo sapiens_hsa005612.01727824
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.97783590
16Alcoholism_Homo sapiens_hsa050341.89350203
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.76696815
18Cyanoamino acid metabolism_Homo sapiens_hsa004601.75028722
19DNA replication_Homo sapiens_hsa030301.74593430
20Selenocompound metabolism_Homo sapiens_hsa004501.66701473
21Vitamin digestion and absorption_Homo sapiens_hsa049771.62400639
22Non-homologous end-joining_Homo sapiens_hsa034501.55082272
23Viral carcinogenesis_Homo sapiens_hsa052031.54675849
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.53033432
25Phototransduction_Homo sapiens_hsa047441.52755545
26Renin-angiotensin system_Homo sapiens_hsa046141.49389900
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.48003462
28Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.44012482
29Homologous recombination_Homo sapiens_hsa034401.33049627
30RNA polymerase_Homo sapiens_hsa030201.30078364
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.23588006
32Arachidonic acid metabolism_Homo sapiens_hsa005901.22268514
33Nucleotide excision repair_Homo sapiens_hsa034201.21439972
34Butanoate metabolism_Homo sapiens_hsa006501.20405369
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19911682
36Spliceosome_Homo sapiens_hsa030401.18782386
37Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.18565679
38p53 signaling pathway_Homo sapiens_hsa041151.17380675
39Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14645132
40Fanconi anemia pathway_Homo sapiens_hsa034601.13921809
41Biosynthesis of amino acids_Homo sapiens_hsa012301.06317955
42Propanoate metabolism_Homo sapiens_hsa006401.05568419
43Cysteine and methionine metabolism_Homo sapiens_hsa002701.05283602
44Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.02809679
45Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01393619
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99110436
47Cell cycle_Homo sapiens_hsa041100.98167902
48Notch signaling pathway_Homo sapiens_hsa043300.98039698
49RNA degradation_Homo sapiens_hsa030180.96319346
50Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.94723092
51Influenza A_Homo sapiens_hsa051640.86978259
52Nitrogen metabolism_Homo sapiens_hsa009100.86913271
53Steroid hormone biosynthesis_Homo sapiens_hsa001400.84154630
54Starch and sucrose metabolism_Homo sapiens_hsa005000.83065851
55Steroid biosynthesis_Homo sapiens_hsa001000.80419526
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.79025392
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77743835
58Nicotine addiction_Homo sapiens_hsa050330.76276851
59Tryptophan metabolism_Homo sapiens_hsa003800.76132504
60Chemical carcinogenesis_Homo sapiens_hsa052040.75994171
61Legionellosis_Homo sapiens_hsa051340.74423444
62Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71766970
63mRNA surveillance pathway_Homo sapiens_hsa030150.71655994
64Sulfur metabolism_Homo sapiens_hsa009200.71101355
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.70995055
66Epstein-Barr virus infection_Homo sapiens_hsa051690.70342480
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.69886908
68Pyrimidine metabolism_Homo sapiens_hsa002400.68057753
69Oxidative phosphorylation_Homo sapiens_hsa001900.67919241
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67565529
71MicroRNAs in cancer_Homo sapiens_hsa052060.66067887
72Arginine and proline metabolism_Homo sapiens_hsa003300.65675266
73Peroxisome_Homo sapiens_hsa041460.65619330
74Lysine degradation_Homo sapiens_hsa003100.64458264
75Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63885262
76Caffeine metabolism_Homo sapiens_hsa002320.57607736
77N-Glycan biosynthesis_Homo sapiens_hsa005100.56235231
78Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.55373342
79Antigen processing and presentation_Homo sapiens_hsa046120.54228267
80Ovarian steroidogenesis_Homo sapiens_hsa049130.53736171
81Colorectal cancer_Homo sapiens_hsa052100.52488470
82Taste transduction_Homo sapiens_hsa047420.50813059
832-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50715056
84Retinol metabolism_Homo sapiens_hsa008300.49289388
85Thyroid cancer_Homo sapiens_hsa052160.48395068
86Base excision repair_Homo sapiens_hsa034100.46149249
87Morphine addiction_Homo sapiens_hsa050320.45641122
88Arginine biosynthesis_Homo sapiens_hsa002200.45138008
89GABAergic synapse_Homo sapiens_hsa047270.44729847
90Metabolic pathways_Homo sapiens_hsa011000.44344542
91Linoleic acid metabolism_Homo sapiens_hsa005910.44120250
92Adherens junction_Homo sapiens_hsa045200.43688627
93Ribosome_Homo sapiens_hsa030100.40642122
94Basal transcription factors_Homo sapiens_hsa030220.40288639
95ABC transporters_Homo sapiens_hsa020100.40281862
96Glycosaminoglycan degradation_Homo sapiens_hsa005310.38972194
97Glycerophospholipid metabolism_Homo sapiens_hsa005640.38667214
98mTOR signaling pathway_Homo sapiens_hsa041500.38412549
99alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.38128735
100Herpes simplex infection_Homo sapiens_hsa051680.38084854
101Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.36703290
102Viral myocarditis_Homo sapiens_hsa054160.36265900
103Endometrial cancer_Homo sapiens_hsa052130.35656332
104Serotonergic synapse_Homo sapiens_hsa047260.35252385
105Parkinsons disease_Homo sapiens_hsa050120.34910951
106Glutamatergic synapse_Homo sapiens_hsa047240.33487457
107Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.33430300
108Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33213130
109Regulation of autophagy_Homo sapiens_hsa041400.32325937
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32100176
111Vitamin B6 metabolism_Homo sapiens_hsa007500.31880730
112Circadian entrainment_Homo sapiens_hsa047130.31812590
113Type I diabetes mellitus_Homo sapiens_hsa049400.30984573
114Histidine metabolism_Homo sapiens_hsa003400.29165720
115Circadian rhythm_Homo sapiens_hsa047100.28620478
116Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.27926720
117Mineral absorption_Homo sapiens_hsa049780.27769201
118Small cell lung cancer_Homo sapiens_hsa052220.26254451
119Primary bile acid biosynthesis_Homo sapiens_hsa001200.26083026
120Sulfur relay system_Homo sapiens_hsa041220.25701883
121Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.25028757
122Central carbon metabolism in cancer_Homo sapiens_hsa052300.24955224
123Purine metabolism_Homo sapiens_hsa002300.24456077
124Olfactory transduction_Homo sapiens_hsa047400.24396604
125Tight junction_Homo sapiens_hsa045300.24134524
126Fatty acid degradation_Homo sapiens_hsa000710.23513473
127Carbon metabolism_Homo sapiens_hsa012000.22622505
128Intestinal immune network for IgA production_Homo sapiens_hsa046720.22594249
129Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22362924
130Non-small cell lung cancer_Homo sapiens_hsa052230.21508581
131Vascular smooth muscle contraction_Homo sapiens_hsa042700.20985924
132Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.20647772
133Huntingtons disease_Homo sapiens_hsa050160.20485602
134Bile secretion_Homo sapiens_hsa049760.20153374
135Glutathione metabolism_Homo sapiens_hsa004800.18440395
136Alzheimers disease_Homo sapiens_hsa050100.18162907
137Sphingolipid metabolism_Homo sapiens_hsa006000.17182511
138Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.17068393
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.16816740
140Apoptosis_Homo sapiens_hsa042100.16780260
141Cocaine addiction_Homo sapiens_hsa050300.15471670
142Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.14081388
143Drug metabolism - other enzymes_Homo sapiens_hsa009830.13114889
144Prostate cancer_Homo sapiens_hsa052150.12523829
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.12489674
146Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.12155869
147Fatty acid biosynthesis_Homo sapiens_hsa000610.11830870
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.11234522
149Salivary secretion_Homo sapiens_hsa049700.11083081
150beta-Alanine metabolism_Homo sapiens_hsa004100.10845450
151Fatty acid metabolism_Homo sapiens_hsa012120.10536414
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.10373319
153Other glycan degradation_Homo sapiens_hsa005110.09655731
154NF-kappa B signaling pathway_Homo sapiens_hsa040640.07896393
155Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.07383292
156Insulin secretion_Homo sapiens_hsa049110.06986963
157Thyroid hormone signaling pathway_Homo sapiens_hsa049190.06352960
158Inositol phosphate metabolism_Homo sapiens_hsa005620.05323935
159HTLV-I infection_Homo sapiens_hsa051660.03369728
160FoxO signaling pathway_Homo sapiens_hsa040680.03351559
161Type II diabetes mellitus_Homo sapiens_hsa049300.03056443
162Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.00895813

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