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Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a serine-type endopeptidase with chymotrypsin- and elastase-2-like activities. The gene encoding this zymogen is expressed specifically in the pancreas and likely functions as a digestive enzyme. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1transcytosis (GO:0045056)8.40580967
2intestinal absorption (GO:0050892)7.99280760
3cobalamin metabolic process (GO:0009235)7.75070383
4sterol catabolic process (GO:0016127)7.73695346
5cholesterol catabolic process (GO:0006707)7.73695346
6negative regulation of epidermis development (GO:0045683)7.51212652
7peptidyl-proline hydroxylation (GO:0019511)7.20913024
8phosphatidylinositol acyl-chain remodeling (GO:0036149)7.17307408
9phosphatidylserine acyl-chain remodeling (GO:0036150)7.15200460
10negative regulation of digestive system process (GO:0060457)6.69840727
11regulation of phospholipase A2 activity (GO:0032429)6.64134231
12phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.63062097
13glycolipid catabolic process (GO:0019377)6.59570125
14membrane lipid catabolic process (GO:0046466)6.30935923
15cysteine metabolic process (GO:0006534)6.27692957
16Golgi transport vesicle coating (GO:0048200)6.15213093
17COPI coating of Golgi vesicle (GO:0048205)6.15213093
18fatty acid derivative transport (GO:1901571)5.83337860
19icosanoid transport (GO:0071715)5.83337860
20proline biosynthetic process (GO:0006561)5.73835107
21tetrapyrrole metabolic process (GO:0033013)5.63380802
22ceramide catabolic process (GO:0046514)5.62917752
23protein hydroxylation (GO:0018126)5.49522498
24branched-chain amino acid catabolic process (GO:0009083)5.38603025
25innate immune response in mucosa (GO:0002227)5.37410725
26phosphatidylethanolamine acyl-chain remodeling (GO:0036152)5.37268095
27protein maturation by protein folding (GO:0022417)5.19337294
28valine metabolic process (GO:0006573)5.18078207
29activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.09421419
30regulation of keratinocyte differentiation (GO:0045616)4.95211613
31positive regulation of nuclease activity (GO:0032075)4.86633112
32cellular modified amino acid catabolic process (GO:0042219)4.77326328
33branched-chain amino acid metabolic process (GO:0009081)4.75086287
34zinc ion transport (GO:0006829)4.74035341
35response to endoplasmic reticulum stress (GO:0034976)4.63808756
36mucosal immune response (GO:0002385)4.61573767
37endoplasmic reticulum unfolded protein response (GO:0030968)4.59771397
38intestinal epithelial cell development (GO:0060576)4.50634932
39cellular response to unfolded protein (GO:0034620)4.46910892
40phosphatidylcholine acyl-chain remodeling (GO:0036151)4.46808765
41serine family amino acid biosynthetic process (GO:0009070)4.43928040
42regulation of nuclease activity (GO:0032069)4.42780496
43defense response to Gram-positive bacterium (GO:0050830)4.35086093
44signal peptide processing (GO:0006465)4.34755196
45homocysteine metabolic process (GO:0050667)4.33920785
46positive regulation of heat generation (GO:0031652)4.33456712
47regulation of keratinocyte proliferation (GO:0010837)4.30703643
48mitochondrial calcium ion transport (GO:0006851)4.29982124
49maintenance of protein localization in organelle (GO:0072595)4.29095889
50cellular response to topologically incorrect protein (GO:0035967)4.26028698
514-hydroxyproline metabolic process (GO:0019471)4.24921329
52organ or tissue specific immune response (GO:0002251)4.24640555
53ER-nucleus signaling pathway (GO:0006984)4.24623187
54leukotriene biosynthetic process (GO:0019370)4.23302503
55aspartate family amino acid catabolic process (GO:0009068)4.17985976
56endocrine pancreas development (GO:0031018)4.16573035
57regulation of sarcomere organization (GO:0060297)4.12496856
58regulation of fever generation (GO:0031620)4.12389409
59phosphatidylserine metabolic process (GO:0006658)4.08490606
60GDP-mannose metabolic process (GO:0019673)4.04363401
61glutamine metabolic process (GO:0006541)4.02004512
62COPII vesicle coating (GO:0048208)3.99821886
63steroid catabolic process (GO:0006706)3.88832295
64ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)3.88425420
65neutrophil mediated immunity (GO:0002446)3.81512309
66water-soluble vitamin metabolic process (GO:0006767)3.81242183
67proline metabolic process (GO:0006560)3.80980348
68creatine metabolic process (GO:0006600)3.73524059
69regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.71578183
70negative regulation of protein localization to cell surface (GO:2000009)3.70005666
71response to unfolded protein (GO:0006986)3.67094453
72retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.63683930
73L-serine metabolic process (GO:0006563)3.61210499
74phosphatidic acid metabolic process (GO:0046473)3.60976103
75phosphatidic acid biosynthetic process (GO:0006654)3.60976103
76sphingolipid catabolic process (GO:0030149)3.60463006
77negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.57571828
78ER overload response (GO:0006983)3.56190549
79L-phenylalanine catabolic process (GO:0006559)3.54586578
80erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.54586578
81response to topologically incorrect protein (GO:0035966)3.54004751
82protein N-linked glycosylation via asparagine (GO:0018279)3.52302292
83coenzyme catabolic process (GO:0009109)3.51930737
84peptidyl-asparagine modification (GO:0018196)3.49442982
85negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.48480185
86negative regulation of organelle assembly (GO:1902116)3.47406077
87antibacterial humoral response (GO:0019731)3.45772933
88serine family amino acid metabolic process (GO:0009069)3.45675943
89phospholipid catabolic process (GO:0009395)3.43596907
90ribonucleoprotein complex disassembly (GO:0032988)3.37023131
91alditol phosphate metabolic process (GO:0052646)3.35227055
92L-alpha-amino acid transmembrane transport (GO:1902475)3.34523297
93L-phenylalanine metabolic process (GO:0006558)3.32899463
94erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.32899463
95leukotriene metabolic process (GO:0006691)3.31001977
96negative regulation of epidermal cell differentiation (GO:0045605)3.30149213
97regulation of heat generation (GO:0031650)3.27978757
98cell redox homeostasis (GO:0045454)3.23901077
99negative regulation of muscle hypertrophy (GO:0014741)3.21575552
100protein N-linked glycosylation (GO:0006487)3.21533539
101antimicrobial humoral response (GO:0019730)3.20272612
102mitochondrion distribution (GO:0048311)3.19309707
103atrioventricular valve morphogenesis (GO:0003181)3.14179781
104pancreas development (GO:0031016)3.13130748
105cholesterol transport (GO:0030301)3.11645560
106sterol transport (GO:0015918)3.11645560
107phosphatidylglycerol metabolic process (GO:0046471)3.11128514
108sulfur amino acid biosynthetic process (GO:0000097)3.08099448
109icosanoid secretion (GO:0032309)3.06397754
110arachidonic acid secretion (GO:0050482)3.06397754
111negative regulation of potassium ion transmembrane transport (GO:1901380)3.05349593
112neutrophil chemotaxis (GO:0030593)3.05195446
113organelle disassembly (GO:1903008)3.00983565
114retinoic acid receptor signaling pathway (GO:0048384)3.00147842
115neutrophil migration (GO:1990266)2.97768664
116regulation of oxidative stress-induced intrinsic apoptotic signaling pathway (GO:1902175)2.96493557
117positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.95035121
118regulation of epidermal cell differentiation (GO:0045604)2.92743588
119myeloid leukocyte mediated immunity (GO:0002444)2.90884770
120membrane raft organization (GO:0031579)2.90596546
121glycine metabolic process (GO:0006544)2.88553095
122digestive system process (GO:0022600)2.87439242
123alpha-amino acid biosynthetic process (GO:1901607)2.87104915
124biotin metabolic process (GO:0006768)2.86796152
125vitamin metabolic process (GO:0006766)2.86193324
126polarized epithelial cell differentiation (GO:0030859)2.85281415
127acute-phase response (GO:0006953)2.84927215
128regulation of oxidative stress-induced cell death (GO:1903201)2.84693407
129regulation of skeletal muscle contraction (GO:0014819)2.84265204
130retina layer formation (GO:0010842)2.80923610
131peptide catabolic process (GO:0043171)2.80217543
132negative regulation of cell fate commitment (GO:0010454)2.79807503
133daunorubicin metabolic process (GO:0044597)2.79490697
134polyketide metabolic process (GO:0030638)2.79490697
135doxorubicin metabolic process (GO:0044598)2.79490697
136glycine transport (GO:0015816)2.76985388
137negative regulation of cardiac muscle hypertrophy (GO:0010614)2.75189436
138cellular protein catabolic process (GO:0044257)2.74903277
139negative regulation of nitric-oxide synthase activity (GO:0051001)2.74260233
140peptidyl-proline modification (GO:0018208)2.73762910
141negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.72669280
142chaperone-mediated protein transport (GO:0072321)2.70359585
143negative regulation of epithelial cell differentiation (GO:0030857)2.70027733
144granulocyte chemotaxis (GO:0071621)2.56123220
145defense response to Gram-negative bacterium (GO:0050829)2.52981815
146aminoglycoside antibiotic metabolic process (GO:0030647)2.48614124
147regulation of p38MAPK cascade (GO:1900744)2.47824115
148plasma membrane repair (GO:0001778)2.47259362
149granulocyte migration (GO:0097530)2.45156458
150positive regulation of wound healing (GO:0090303)2.45093127
151positive regulation of microtubule polymerization (GO:0031116)2.43675883
152primary alcohol catabolic process (GO:0034310)2.42334115
153alcohol catabolic process (GO:0046164)2.34780557
154cytokine production (GO:0001816)2.32716741
155regulation of action potential (GO:0098900)2.32080937
156endothelial cell migration (GO:0043542)2.28579231
157cholesterol metabolic process (GO:0008203)2.27868032
158negative regulation of heart growth (GO:0061117)2.27814634
159negative regulation of cardiac muscle tissue growth (GO:0055022)2.27814634
160positive regulation by organism of defense response of other organism involved in symbiotic interact2.26398524
161modulation by symbiont of host immune response (GO:0052553)2.26398524
162modulation by symbiont of host defense response (GO:0052031)2.26398524
163modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.26398524
164intestinal cholesterol absorption (GO:0030299)18.0630697
165exocrine pancreas development (GO:0031017)17.4122135
166* digestion (GO:0007586)12.7593525
167protein retention in ER lumen (GO:0006621)12.4555435
168maintenance of protein localization in endoplasmic reticulum (GO:0035437)11.6977190

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat8.37629061
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.99193104
3ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.12129430
4STAT6_21828071_ChIP-Seq_BEAS2B_Human3.73478648
5ERG_21242973_ChIP-ChIP_JURKAT_Human3.13844366
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.00847712
7RXR_22158963_ChIP-Seq_LIVER_Mouse2.69729992
8PPARA_22158963_ChIP-Seq_LIVER_Mouse2.65145274
9ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.61572691
10GATA1_22025678_ChIP-Seq_K562_Human2.57021143
11GATA4_25053715_ChIP-Seq_YYC3_Human2.47522319
12SOX2_27498859_Chip-Seq_STOMACH_Mouse2.41468389
13GATA1_26923725_Chip-Seq_HPCs_Mouse2.36925251
14VDR_22108803_ChIP-Seq_LS180_Human2.35934626
15LXR_22158963_ChIP-Seq_LIVER_Mouse2.33859704
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.26154482
17ESR1_21235772_ChIP-Seq_MCF-7_Human2.08019456
18STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.04336093
19GATA6_25053715_ChIP-Seq_YYC3_Human2.01821067
20KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.99886134
21KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.99886134
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.99886134
23PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.99014248
24ESR2_21235772_ChIP-Seq_MCF-7_Human1.98661131
25FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.91333746
26TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.73752261
27NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70647731
28CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.65041405
29PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.61775122
30NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.54639080
31* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.54175630
32PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.49514817
33SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42698841
34CREB1_26743006_Chip-Seq_LNCaP_Human1.41066488
35GATA6_21074721_ChIP-Seq_CACO-2_Human1.40871704
36HNFA_21074721_ChIP-Seq_CACO-2_Human1.39924491
37GABP_17652178_ChIP-ChIP_JURKAT_Human1.38553067
38CHD1_26751641_Chip-Seq_LNCaP_Human1.38368904
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.36190796
40RBPJ_21746931_ChIP-Seq_IB4_Human1.35363058
41HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.33982880
42GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.33745420
43ETV1_20927104_ChIP-Seq_GIST48_Human1.32981100
44SA1_27219007_Chip-Seq_ERYTHROID_Human1.32357360
45PHF8_20622853_ChIP-Seq_HELA_Human1.32207933
46CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.31784529
47P68_20966046_ChIP-Seq_HELA_Human1.31457056
48LXR_22292898_ChIP-Seq_THP-1_Human1.28127177
49RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25485935
50P63_26484246_Chip-Seq_KERATINOCYTES_Human1.24865095
51NFYA_21822215_ChIP-Seq_K562_Human1.24365995
52CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.21206746
53SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.20984481
54* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20320727
55PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.19057181
56IRF1_19129219_ChIP-ChIP_H3396_Human1.18568234
57EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.18202293
58CBX2_22325352_ChIP-Seq_293T-Rex_Human1.16758599
59FOXH1_21741376_ChIP-Seq_ESCs_Human1.14718322
60SOX2_20726797_ChIP-Seq_SW620_Human1.13614574
61TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12698984
62* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.11358977
63EST1_17652178_ChIP-ChIP_JURKAT_Human1.10942192
64* EGR1_19032775_ChIP-ChIP_M12_Human1.09449473
65ERA_21632823_ChIP-Seq_H3396_Human1.09429212
66NOTCH1_21737748_ChIP-Seq_TLL_Human1.09224267
67PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.08829273
68ERG_20517297_ChIP-Seq_VCAP_Human1.08553086
69BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.08110686
70SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.07992808
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.07982461
72ATF3_27146783_Chip-Seq_COLON_Human1.07925811
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.06760836
74FOXA2_19822575_ChIP-Seq_HepG2_Human1.06679453
75* IRF8_22096565_ChIP-ChIP_GC-B_Human1.06541348
76SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06198736
77TAF2_19829295_ChIP-Seq_ESCs_Human1.05350326
78NFYB_21822215_ChIP-Seq_K562_Human1.04363567
79OCT4_20526341_ChIP-Seq_ESCs_Human1.04182735
80CLOCK_20551151_ChIP-Seq_293T_Human1.03589664
81FOXA1_25552417_ChIP-Seq_VCAP_Human1.03221676
82DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.03021293
83AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.03009801
84CDX2_20551321_ChIP-Seq_CACO-2_Human1.02624057
85HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.01355207
86* TP63_22573176_ChIP-Seq_HFKS_Human1.01146917
87ETS1_21867929_ChIP-Seq_TH2_Mouse1.00670202
88* ESET_19884257_ChIP-Seq_ESCs_Mouse1.00616075
89GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.00374635
90IRF8_21731497_ChIP-ChIP_J774_Mouse0.99825829
91KLF4_19829295_ChIP-Seq_ESCs_Human0.98175283
92RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97198432
93ELF1_17652178_ChIP-ChIP_JURKAT_Human0.96973081
94RUNX1_27514584_Chip-Seq_MCF-7_Human0.96144196
95ETV2_25802403_ChIP-Seq_MESCs_Mouse0.96093690
96TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.95914449
97CTCF_27219007_Chip-Seq_Bcells_Human0.95866794
98SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95006313
99P53_21459846_ChIP-Seq_SAOS-2_Human0.94863515
100CEBPB_22108803_ChIP-Seq_LS180_Human0.94559102
101FOXO3_23340844_ChIP-Seq_DLD1_Human0.94345519
102HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94329462
103* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.94012955
104DNAJC2_21179169_ChIP-ChIP_NT2_Human0.93498879
105BCOR_27268052_Chip-Seq_Bcells_Human0.93480210
106ZNF274_21170338_ChIP-Seq_K562_Hela0.92820941
107FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.92468513
108ELK4_26923725_Chip-Seq_MESODERM_Mouse0.92332913
109CTCF_20526341_ChIP-Seq_ESCs_Human0.90780683
110ETS1_20019798_ChIP-Seq_JURKAT_Human0.90764056
111SA1_27219007_Chip-Seq_Bcells_Human0.89774981
112PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89655184
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.88169249
114VDR_23849224_ChIP-Seq_CD4+_Human0.87919769
115FOXP1_21924763_ChIP-Seq_HESCs_Human0.87299638
116RACK7_27058665_Chip-Seq_MCF-7_Human0.85889310
117FLI1_21867929_ChIP-Seq_CD8_Mouse0.85850483
118ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.85291172
119P300_27268052_Chip-Seq_Bcells_Human0.84805898
120NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.84149793
121GATA3_24758297_ChIP-Seq_MCF-7_Human0.83857634
122GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.83473165
123ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.83434806
124KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.81930449
125PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.81593927
126SOX3_22085726_ChIP-Seq_MUSCLE_Mouse0.80742425
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.79377451
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.78609963
129GATA3_27048872_Chip-Seq_THYMUS_Human0.78355193
130AR_20517297_ChIP-Seq_VCAP_Human0.77932179
131HTT_18923047_ChIP-ChIP_STHdh_Human0.77718337
132LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.77437900
133CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.77396518
134TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.76090709
135SOX2_22085726_ChIP-Seq_NPCs_Mouse0.74668075
136TBX5_21415370_ChIP-Seq_HL-1_Mouse0.74541012
137SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.74536893
138EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.72418398
139MYC_19079543_ChIP-ChIP_MESCs_Mouse0.71657254
140FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69800663
141BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.69253574
142RUNX_20019798_ChIP-Seq_JUKART_Human0.68293165
143TBL1_22424771_ChIP-Seq_293T_Human0.67440766
144SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.67344971
145CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.65980702
146* IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.65494560
147CTCF_18555785_ChIP-Seq_MESCs_Mouse0.65471425
148NANOG_20526341_ChIP-Seq_ESCs_Human0.64765207
149HOXB7_26014856_ChIP-Seq_BT474_Human0.64399863
150SPI1_20517297_ChIP-Seq_HL60_Human0.61860314
151* MYC_19829295_ChIP-Seq_ESCs_Human0.60890763
152SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.59978712
153NCOR_22424771_ChIP-Seq_293T_Human0.59704271
154FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.59016876
155LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse0.58682399
156SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.56865063
157VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.56617751
158* SOX2_21211035_ChIP-Seq_LN229_Human0.56586273
159P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.56415093
160HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.56305576
161MYB_26560356_Chip-Seq_TH2_Human0.55732907
162CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.55446276
163P53_22127205_ChIP-Seq_FIBROBLAST_Human0.54439571
164FOXH1_21741376_ChIP-Seq_EPCs_Human0.54222384
165FOXP3_21729870_ChIP-Seq_TREG_Human0.54191302
166CBP_20019798_ChIP-Seq_JUKART_Human0.54047554
167IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.54047554

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract9.25777718
2MP0001666_abnormal_nutrient_absorption9.13566631
3MP0005220_abnormal_exocrine_pancreas6.81557553
4MP0005365_abnormal_bile_salt6.50815270
5MP0005084_abnormal_gallbladder_morpholo4.95091150
6MP0003868_abnormal_feces_composition4.92135929
7MP0005085_abnormal_gallbladder_physiolo3.29006712
8MP0002693_abnormal_pancreas_physiology3.03685544
9MP0003950_abnormal_plasma_membrane2.87951212
10MP0003959_abnormal_lean_body2.64861736
11MP0001664_abnormal_digestion2.47377641
12MP0002138_abnormal_hepatobiliary_system2.45730830
13MP0002139_abnormal_hepatobiliary_system2.22401160
14MP0001944_abnormal_pancreas_morphology2.09536718
15MP0003705_abnormal_hypodermis_morpholog1.84234611
16MP0002102_abnormal_ear_morphology1.77617104
17MP0004264_abnormal_extraembryonic_tissu1.69100275
18MP0005448_abnormal_energy_balance1.66289701
19MP0004233_abnormal_muscle_weight1.54806796
20MP0003252_abnormal_bile_duct1.54701085
21MP0003638_abnormal_response/metabolism_1.50348239
22MP0010234_abnormal_vibrissa_follicle1.44486732
23MP0003436_decreased_susceptibility_to1.42607465
24MP0002928_abnormal_bile_duct1.41693638
25MP0002277_abnormal_respiratory_mucosa1.40383068
26MP0002118_abnormal_lipid_homeostasis1.35659746
27MP0002163_abnormal_gland_morphology1.26790902
28MP0005332_abnormal_amino_acid1.25798299
29MP0005165_increased_susceptibility_to1.24662853
30MP0005451_abnormal_body_composition1.24622070
31MP0006292_abnormal_olfactory_placode1.21955359
32MP0002078_abnormal_glucose_homeostasis1.16273015
33MP0002653_abnormal_ependyma_morphology1.13915641
34MP0003828_pulmonary_edema1.13589637
35MP0003763_abnormal_thymus_physiology1.13486802
36MP0003724_increased_susceptibility_to1.10913719
37MP0002132_abnormal_respiratory_system1.09217150
38MP0008004_abnormal_stomach_pH1.05895357
39MP0003011_delayed_dark_adaptation1.03738554
40MP0000003_abnormal_adipose_tissue1.00581318
41MP0005377_hearing/vestibular/ear_phenot0.99843811
42MP0003878_abnormal_ear_physiology0.99843811
43MP0001790_abnormal_immune_system0.99296606
44MP0005387_immune_system_phenotype0.99296606
45MP0000470_abnormal_stomach_morphology0.97178959
46MP0000749_muscle_degeneration0.93077185
47MP0001873_stomach_inflammation0.89857601
48MP0005408_hypopigmentation0.89747838
49MP0009643_abnormal_urine_homeostasis0.88837927
50MP0005535_abnormal_body_temperature0.87236824
51MP0008995_early_reproductive_senescence0.84925018
52MP0003045_fibrosis0.82017030
53MP0009785_altered_susceptibility_to0.81452354
54MP0001800_abnormal_humoral_immune0.80667364
55MP0003300_gastrointestinal_ulcer0.80575655
56MP0003953_abnormal_hormone_level0.80314471
57MP0000685_abnormal_immune_system0.79704263
58MP0009384_cardiac_valve_regurgitation0.76613327
59MP0008438_abnormal_cutaneous_collagen0.76279525
60MP0002837_dystrophic_cardiac_calcinosis0.76194441
61MP0000490_abnormal_crypts_of0.75271290
62MP0002723_abnormal_immune_serum0.74697698
63MP0003283_abnormal_digestive_organ0.71745748
64MP0008961_abnormal_basal_metabolism0.70877647
65MP0001485_abnormal_pinna_reflex0.70219088
66MP0005058_abnormal_lysosome_morphology0.70188844
67MP0003866_abnormal_defecation0.70097392
68MP0002420_abnormal_adaptive_immunity0.70064548
69MP0006054_spinal_hemorrhage0.69614169
70MP0008872_abnormal_physiological_respon0.69423355
71MP0009780_abnormal_chondrocyte_physiolo0.69259223
72MP0001819_abnormal_immune_cell0.68089391
73MP0000613_abnormal_salivary_gland0.67228536
74MP0005000_abnormal_immune_tolerance0.65158584
75MP0008877_abnormal_DNA_methylation0.65088664
76MP0005452_abnormal_adipose_tissue0.64572081
77MP0002405_respiratory_system_inflammati0.64503350
78MP0008789_abnormal_olfactory_epithelium0.61802152
79MP0002970_abnormal_white_adipose0.61406850
80MP0001663_abnormal_digestive_system0.61219208
81MP0003123_paternal_imprinting0.59600567
82MP0003806_abnormal_nucleotide_metabolis0.59105229
83MP0009765_abnormal_xenobiotic_induced0.59001517
84MP0005075_abnormal_melanosome_morpholog0.58327586
85MP0001502_abnormal_circadian_rhythm0.57920351
86MP0001764_abnormal_homeostasis0.57530025
87MP0010329_abnormal_lipoprotein_level0.57009724
88MP0000858_altered_metastatic_potential0.56908524
89MP0000598_abnormal_liver_morphology0.56726704
90MP0000703_abnormal_thymus_morphology0.56276749
91MP0002452_abnormal_antigen_presenting0.56154079
92MP0008469_abnormal_protein_level0.56079593
93MP0002419_abnormal_innate_immunity0.56058983
94MP0000689_abnormal_spleen_morphology0.55554466
95MP0001501_abnormal_sleep_pattern0.55401740
96MP0005025_abnormal_response_to0.53453350
97MP0006036_abnormal_mitochondrial_physio0.53026177
98MP0000716_abnormal_immune_system0.52880410
99MP0010155_abnormal_intestine_physiology0.52632782
100MP0005360_urolithiasis0.52145330
101MP0003186_abnormal_redox_activity0.51977229
102MP0001853_heart_inflammation0.51642118
103MP0001533_abnormal_skeleton_physiology0.51233500
104MP0002398_abnormal_bone_marrow0.51064256
105MP0009379_abnormal_foot_pigmentation0.51027135
106MP0001731_abnormal_postnatal_growth0.50972345
107MP0003786_premature_aging0.50607394
108MP0002148_abnormal_hypersensitivity_rea0.50490144
109MP0003879_abnormal_hair_cell0.50105030
110MP0005381_digestive/alimentary_phenotyp0.50063481
111MP0002089_abnormal_postnatal_growth/wei0.49732707
112MP0000609_abnormal_liver_physiology0.49460269
113MP0009764_decreased_sensitivity_to0.48089026
114MP0002722_abnormal_immune_system0.47080758
115MP0001845_abnormal_inflammatory_respons0.46399987
116MP0005375_adipose_tissue_phenotype0.45553975
117MP0005499_abnormal_olfactory_system0.44633083
118MP0005394_taste/olfaction_phenotype0.44633083
119MP0002876_abnormal_thyroid_physiology0.43980807
120MP0002098_abnormal_vibrissa_morphology0.43642254
121MP0001851_eye_inflammation0.43099258
122MP0004043_abnormal_pH_regulation0.41779295
123MP0003693_abnormal_embryo_hatching0.41629220
124MP0000750_abnormal_muscle_regeneration0.41561180
125MP0008770_decreased_survivor_rate0.41323091
126MP0005671_abnormal_response_to0.40884109
127MP0003183_abnormal_peptide_metabolism0.40750828
128MP0005319_abnormal_enzyme/_coenzyme0.39689284
129MP0002933_joint_inflammation0.38973993
130MP0003795_abnormal_bone_structure0.37326057
131MP0005334_abnormal_fat_pad0.36106784
132MP0001348_abnormal_lacrimal_gland0.35746757
133MP0000371_diluted_coat_color0.35703628
134MP0002796_impaired_skin_barrier0.34131818
135MP0002896_abnormal_bone_mineralization0.33669593
136MP0009642_abnormal_blood_homeostasis0.32376410
137MP0004185_abnormal_adipocyte_glucose0.32237667
138MP0000367_abnormal_coat/_hair0.32118844
139MP0003195_calcinosis0.30828565
140MP0002877_abnormal_melanocyte_morpholog0.30642828
141MP0005187_abnormal_penis_morphology0.30552368
142MP0010386_abnormal_urinary_bladder0.30369019
143MP0002060_abnormal_skin_morphology0.30208414
144MP0003656_abnormal_erythrocyte_physiolo0.29807434
145MP0002069_abnormal_eating/drinking_beha0.29797888
146MP0003329_amyloid_beta_deposits0.29775332
147MP0000377_abnormal_hair_follicle0.29641177
148MP0000955_abnormal_spinal_cord0.29093485
149MP0003943_abnormal_hepatobiliary_system0.29084783
150MP0000013_abnormal_adipose_tissue0.28391549
151MP0003172_abnormal_lysosome_physiology0.25885212
152MP0000647_abnormal_sebaceous_gland0.24767641
153MP0005636_abnormal_mineral_homeostasis0.24434300
154MP0009703_decreased_birth_body0.22850929
155MP0001756_abnormal_urination0.22674150
156MP0003956_abnormal_body_size0.21799080
157MP0001765_abnormal_ion_homeostasis0.21714141
158MP0004924_abnormal_behavior0.21270768

Predicted human phenotypes

RankGene SetZ-score
1Steatorrhea (HP:0002570)8.38932583
2Fat malabsorption (HP:0002630)7.01290923
3Gout (HP:0001997)6.53077277
4Short chin (HP:0000331)6.29552313
5Decreased subcutaneous fat (HP:0001002)6.26872601
6Abnormality of subcutaneous fat tissue (HP:0001001)5.55886607
7Type I diabetes mellitus (HP:0100651)5.40988827
8Exocrine pancreatic insufficiency (HP:0001738)5.20280944
9Maternal diabetes (HP:0009800)4.90338646
10Abnormality of the intrinsic pathway (HP:0010989)4.73498190
11Abnormal pancreas size (HP:0012094)4.36274640
12Hypoplasia of the pons (HP:0012110)4.17692589
13Calf muscle hypertrophy (HP:0008981)3.99240498
14Abnormality of aromatic amino acid family metabolism (HP:0004338)3.97189563
15Abnormality of the pleura (HP:0002103)3.97133100
16Abnormality of the pons (HP:0007361)3.94249184
17Joint stiffness (HP:0001387)3.87706245
18Ketoacidosis (HP:0001993)3.80977998
19Ketosis (HP:0001946)3.78956958
20Elevated erythrocyte sedimentation rate (HP:0003565)3.74295229
21Premature skin wrinkling (HP:0100678)3.71717298
22Pancreatitis (HP:0001733)3.70388457
23Tubulointerstitial fibrosis (HP:0005576)3.55346522
24Exercise-induced myalgia (HP:0003738)3.52537841
25Abnormality of endocrine pancreas physiology (HP:0012093)3.51786350
26Abnormality of the pancreatic islet cells (HP:0006476)3.51786350
27Hypoglycemic coma (HP:0001325)3.50325231
28Cortical dysplasia (HP:0002539)3.44734660
29Muscle hypertrophy of the lower extremities (HP:0008968)3.40298809
30Hypoproteinemia (HP:0003075)3.38757515
31Tubulointerstitial nephritis (HP:0001970)3.34577431
32Hypoglycemic seizures (HP:0002173)3.31782475
33Hyperinsulinemic hypoglycemia (HP:0000825)3.14408535
34Subaortic stenosis (HP:0001682)3.01590663
35Abnormality of the left ventricular outflow tract (HP:0011103)3.01590663
36Abnormality of the common coagulation pathway (HP:0010990)2.96652054
37Carpal bone hypoplasia (HP:0001498)2.93838668
38Increased purine levels (HP:0004368)2.91796828
39Hyperuricemia (HP:0002149)2.91796828
40Optic nerve hypoplasia (HP:0000609)2.86538703
41Late onset (HP:0003584)2.85306856
42Hyperglycinemia (HP:0002154)2.85231612
43Hypoplasia of the thymus (HP:0000778)2.84965452
44Stomatitis (HP:0010280)2.84353673
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.83934967
46Long foot (HP:0001833)2.80752504
47Abnormal protein glycosylation (HP:0012346)2.71464568
48Abnormal glycosylation (HP:0012345)2.71464568
49Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.71464568
50Abnormal protein N-linked glycosylation (HP:0012347)2.71464568
51Prenatal maternal abnormality (HP:0002686)2.69849738
52Asymmetric septal hypertrophy (HP:0001670)2.62621248
53Progressive muscle weakness (HP:0003323)2.59526682
54Anal atresia (HP:0002023)2.58952003
55Abnormal hair whorl (HP:0010721)2.51986782
56Pectus carinatum (HP:0000768)2.47992025
57Hyperglycinuria (HP:0003108)2.47850258
58Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.46343191
59Dysostosis multiplex (HP:0000943)2.45224531
60Congenital glaucoma (HP:0001087)2.44898570
61Renal cortical cysts (HP:0000803)2.39432690
62Muscle stiffness (HP:0003552)2.39009236
63Type 2 muscle fiber atrophy (HP:0003554)2.38421494
64Fatigue (HP:0012378)2.37868134
65Brushfield spots (HP:0001088)2.35053498
66Abnormality of glycine metabolism (HP:0010895)2.35029642
67Abnormality of serine family amino acid metabolism (HP:0010894)2.35029642
68Abnormal tarsal ossification (HP:0008369)2.34926935
69Symptomatic seizures (HP:0011145)2.34816222
70Gowers sign (HP:0003391)2.33502062
71Esophageal varix (HP:0002040)2.30337673
72Hyperglycemia (HP:0003074)2.28595954
73Hypoplasia of the odontoid process (HP:0003311)2.24690777
74Progressive cerebellar ataxia (HP:0002073)2.24470525
75Abnormality of the renal cortex (HP:0011035)2.23411981
76Vacuolated lymphocytes (HP:0001922)2.23159950
77Acute hepatic failure (HP:0006554)2.22683739
78Poor suck (HP:0002033)2.19035997
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.18684346
80Ventricular fibrillation (HP:0001663)2.16572241
81Abnormality of methionine metabolism (HP:0010901)2.15696164
82Parakeratosis (HP:0001036)2.15372604
83Homocystinuria (HP:0002156)2.13304149
84Abnormality of homocysteine metabolism (HP:0010919)2.13304149
85Type II lissencephaly (HP:0007260)2.11980088
86Cortical visual impairment (HP:0100704)2.10983608
87Large for gestational age (HP:0001520)2.09131818
88Muscle fiber atrophy (HP:0100295)2.08345113
89Genetic anticipation (HP:0003743)2.06465418
90Abnormality of purine metabolism (HP:0004352)2.05229266
91Tubulointerstitial abnormality (HP:0001969)2.04083924
92Recurrent gram-negative bacterial infections (HP:0005420)2.03702039
93Myotonia (HP:0002486)2.03560805
94Hypoplasia of the uterus (HP:0000013)2.03502417
95Aplasia/Hypoplasia of the thymus (HP:0010515)2.03200746
96Methylmalonic aciduria (HP:0012120)2.03040533
97Exercise-induced muscle cramps (HP:0003710)2.02018760
98Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.01385087
99Reduced antithrombin III activity (HP:0001976)1.99476195
100Myocardial infarction (HP:0001658)1.99073390
101Small epiphyses (HP:0010585)1.98277295
102Pancreatic cysts (HP:0001737)1.96848299
103Sudden death (HP:0001699)1.96363028
104Myositis (HP:0100614)1.95867771
105Hypsarrhythmia (HP:0002521)1.93660928
106Abnormal hemoglobin (HP:0011902)1.93217554
107Conjugated hyperbilirubinemia (HP:0002908)1.91763104
108Abnormal biliary tract morphology (HP:0012440)1.90233871
109Optic neuritis (HP:0100653)1.90067515
110Retrobulbar optic neuritis (HP:0100654)1.90067515
111Ankyloglossia (HP:0010296)1.89849523
112Prolonged QT interval (HP:0001657)1.88718058
113Tubular atrophy (HP:0000092)1.88664287
114Opisthotonus (HP:0002179)1.88100206
115Barrel-shaped chest (HP:0001552)1.87794625
116Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.87432127
117Beaking of vertebral bodies (HP:0004568)1.86753840
118Facial shape deformation (HP:0011334)1.85426320
119Potter facies (HP:0002009)1.85426320
120Chronic hepatic failure (HP:0100626)1.84214088
121EEG with generalized epileptiform discharges (HP:0011198)1.84027554
122Abnormality of aspartate family amino acid metabolism (HP:0010899)1.83725744
123Severe short stature (HP:0003510)1.80818312
124Hypochromic microcytic anemia (HP:0004840)1.80674268
125Male infertility (HP:0003251)1.79369526
126Limb hypertonia (HP:0002509)1.79011766
127Constricted visual fields (HP:0001133)1.78399050
128Infantile muscular hypotonia (HP:0008947)1.77596736
129Abnormality of the odontoid process (HP:0003310)1.76868763
130Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.76046807
131Sex reversal (HP:0012245)1.75871900
132Abnormal sex determination (HP:0012244)1.75871900
133Mucopolysacchariduria (HP:0008155)1.75500059
134Urinary glycosaminoglycan excretion (HP:0003541)1.75500059
135Recurrent bacterial skin infections (HP:0005406)1.75302569
136Orchitis (HP:0100796)1.75114329
137Epileptiform EEG discharges (HP:0011182)1.74844542
138Popliteal pterygium (HP:0009756)1.73745002
139Renal salt wasting (HP:0000127)1.73357743
140Neonatal death (HP:0003811)1.72614534
141Large hands (HP:0001176)1.71950157
142Abnormal foot bone ossification (HP:0010675)1.71668682
143Macrocytic anemia (HP:0001972)1.71519661
144Abnormal rod and cone electroretinograms (HP:0008323)1.71257850
145Acute necrotizing encephalopathy (HP:0006965)1.68816563
146Type I transferrin isoform profile (HP:0003642)1.68698448
147Mitochondrial inheritance (HP:0001427)1.68428273
148Abnormality of the renal medulla (HP:0100957)1.66175033
149Median cleft lip (HP:0000161)1.63880239
150Recurrent abscess formation (HP:0002722)1.63679483
151Pancreatic fibrosis (HP:0100732)1.63032882
152Acute encephalopathy (HP:0006846)1.62999504
153Methylmalonic acidemia (HP:0002912)1.62770183
154Medial flaring of the eyebrow (HP:0010747)1.61968598
155Abnormal EKG (HP:0003115)1.60801997
156Abnormality of the thymus (HP:0000777)1.59063702
157Enlarged kidneys (HP:0000105)1.57479236
158Abnormality of the nasal septum (HP:0000419)1.56504050
159Severe visual impairment (HP:0001141)1.53665462
160Abnormality of the aortic arch (HP:0012303)1.48897049
161Aplastic anemia (HP:0001915)1.48423627
162Poor coordination (HP:0002370)1.48007767
163Eczematoid dermatitis (HP:0000976)1.47682283
164Abnormal cartilage morphology (HP:0002763)1.43628551
165Abnormality of male internal genitalia (HP:0000022)1.43081300
166Nonprogressive disorder (HP:0003680)1.42969408
167Episodic fever (HP:0001954)1.41714725
168Hypomagnesemia (HP:0002917)1.41000283
169Left ventricular hypertrophy (HP:0001712)1.40804304
170Abnormal mitochondria in muscle tissue (HP:0008316)1.40604630
171Double outlet right ventricle (HP:0001719)1.39688482
172Congenital malformation of the right heart (HP:0011723)1.39688482
173Anorexia (HP:0002039)1.38460705
174Increased CSF lactate (HP:0002490)1.37883939

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK9.47717289
2ERN15.58254215
3INSRR4.34686012
4EIF2AK34.15486954
5MAP2K23.76467234
6LMTK23.51164220
7TRIB32.91793341
8PKN22.60410715
9MUSK2.48310936
10MAPKAPK52.43528629
11FRK2.41866981
12CDK82.20019051
13MAP3K112.12549645
14MAPKAPK32.08141193
15NLK1.98484880
16TAOK31.96387599
17SCYL21.94781780
18MAPK151.93181773
19ZAP701.87050858
20IRAK31.69884045
21CDK191.65775758
22MST41.58700465
23GRK11.55077828
24MAP4K11.51390843
25MAP2K11.50192044
26MELK1.49282017
27NME11.43813900
28PAK21.42320269
29TAOK11.34051055
30NME21.33729173
31TNIK1.31266740
32WNK41.25265302
33IKBKE1.24320455
34EPHA21.24256265
35TXK1.20549237
36BMPR1B1.20489751
37BLK1.19633366
38PTK61.17945376
39FES1.12992795
40DYRK1A1.12054229
41PIK3CG1.11949213
42FLT31.11022903
43DMPK1.06957068
44RPS6KB21.06151470
45MAP3K21.05632951
46PDGFRB1.04803082
47MARK21.04534701
48TEC1.04081700
49IKBKB1.01483808
50ADRBK21.00320325
51TNK20.99530909
52GRK60.97389088
53SIK10.89677132
54DYRK1B0.88932753
55CCNB10.88192595
56MATK0.87490727
57EEF2K0.87432117
58CAMKK10.85706745
59CSK0.85242171
60CAMKK20.82706412
61IRAK20.82570659
62MAP2K30.82407169
63PIK3CA0.81077522
64SGK20.78374151
65MAPK70.77677017
66DAPK20.76968291
67STK110.74770436
68RIPK40.74030687
69PRKCQ0.73677096
70SYK0.72588776
71TYK20.72461123
72SGK30.71468071
73LYN0.71424742
74NUAK10.69322066
75PRKCH0.68234773
76MTOR0.67907938
77CDK40.65273764
78RIPK10.64860662
79MAP2K60.64729906
80IRAK40.63195663
81LATS10.62967216
82MAP3K10.61544760
83MARK30.61158422
84PRKD30.60602846
85BTK0.60373381
86PDK20.59203392
87RET0.59021132
88PRKCI0.58888165
89PASK0.54006117
90OXSR10.52462322
91LCK0.52092847
92SGK2230.50902380
93SGK4940.50902380
94RPS6KB10.50691922
95MAP3K50.50556390
96PDPK10.50268531
97PRKCZ0.49204628
98EIF2AK10.48151838
99IRAK10.48144403
100PIM10.46328265
101MAP4K20.46021258
102HIPK20.45525415
103STK390.44914726
104NTRK10.44860194
105FER0.43372532
106FGFR40.41973943
107PDGFRA0.41598525
108ITK0.41519171
109MAPK120.41221165
110PINK10.41194992
111CAMK40.40403914
112VRK10.40267042
113EPHB10.39915419
114EPHA30.38756181
115KSR20.38649279
116CDK90.38620540
117EIF2AK20.38077201
118WNK30.38050491
119PDK10.37846631
120TAOK20.36834900
121JAK10.36558979
122CHUK0.35888884
123JAK20.35021715
124DAPK10.34387369
125NEK60.34121997
126PRKD10.32653732
127MAP3K70.32276437
128PTK20.32220932
129PRKD20.31777927
130KIT0.30765629
131LRRK20.30400937
132MAPK30.30084228
133HCK0.29728211
134TSSK60.29538224
135PRKG20.28198510
136PRKACB0.26430318
137SIK30.26030148
138MET0.24676826
139CAMK1D0.22884117
140RPS6KA10.21670892
141DYRK20.20800109
142ABL10.20738791
143MAP3K30.19860712
144TBK10.19849586
145IGF1R0.19306901
146NTRK30.16252380
147MAPK10.15960489
148PRKAA10.15545762
149MAP3K90.15147856
150GSK3A0.14691441
151ILK0.14609316
152BRAF0.13897815
153CDC42BPA0.11932407
154MST1R0.11001727
155PDK40.09955951
156PDK30.09955951
157PRKACA0.09418007
158EGFR0.09222938
159MAPK110.09159353
160DDR20.08771276
161AKT10.08614100
162CSNK1G20.07883757
163CSNK1A10.07808857
164STK160.07794353
165CSNK1E0.07505086

Predicted pathways (KEGG)

RankGene SetZ-score
1* Pancreatic secretion_Homo sapiens_hsa049728.07703149
2Fat digestion and absorption_Homo sapiens_hsa049756.05675309
3* Protein digestion and absorption_Homo sapiens_hsa049745.18522667
4Maturity onset diabetes of the young_Homo sapiens_hsa049503.90762674
5Protein export_Homo sapiens_hsa030603.68765820
6Folate biosynthesis_Homo sapiens_hsa007903.06392992
7Glycerolipid metabolism_Homo sapiens_hsa005612.93183936
8Cyanoamino acid metabolism_Homo sapiens_hsa004602.62349992
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.53292460
10Protein processing in endoplasmic reticulum_Homo sapiens_hsa041412.46292940
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.06876455
12Vitamin digestion and absorption_Homo sapiens_hsa049771.90956733
13Steroid biosynthesis_Homo sapiens_hsa001001.87228406
14Propanoate metabolism_Homo sapiens_hsa006401.66753554
15Renin-angiotensin system_Homo sapiens_hsa046141.58633737
16Arginine and proline metabolism_Homo sapiens_hsa003301.17354738
17alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.16106683
18Linoleic acid metabolism_Homo sapiens_hsa005911.12919043
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07318260
20Ribosome_Homo sapiens_hsa030101.05863111
21Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.05491886
22N-Glycan biosynthesis_Homo sapiens_hsa005101.05267290
232-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.95272312
24Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91305882
25Biosynthesis of amino acids_Homo sapiens_hsa012300.90710672
26Other glycan degradation_Homo sapiens_hsa005110.90605218
27Insulin secretion_Homo sapiens_hsa049110.89546338
28Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.88342515
29Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86390296
30Selenocompound metabolism_Homo sapiens_hsa004500.83954554
31Starch and sucrose metabolism_Homo sapiens_hsa005000.83464537
32Sulfur metabolism_Homo sapiens_hsa009200.77564964
33Cysteine and methionine metabolism_Homo sapiens_hsa002700.77319639
34Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76128444
35Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.73839216
36Influenza A_Homo sapiens_hsa051640.72341201
37Vibrio cholerae infection_Homo sapiens_hsa051100.69403402
38Oxidative phosphorylation_Homo sapiens_hsa001900.68549807
39Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67206649
40Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.66769408
41Notch signaling pathway_Homo sapiens_hsa043300.64487825
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.63656841
43One carbon pool by folate_Homo sapiens_hsa006700.59022074
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.58416088
45Primary bile acid biosynthesis_Homo sapiens_hsa001200.57942284
46Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.57407065
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.55986739
48beta-Alanine metabolism_Homo sapiens_hsa004100.53967122
49Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.52913830
50RNA polymerase_Homo sapiens_hsa030200.50197654
51Circadian rhythm_Homo sapiens_hsa047100.49842472
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49703798
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48334620
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.45536206
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.44695249
56Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43973259
57Pyruvate metabolism_Homo sapiens_hsa006200.42827690
58Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.42556235
59Fatty acid degradation_Homo sapiens_hsa000710.40921714
60Jak-STAT signaling pathway_Homo sapiens_hsa046300.40055546
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.38856964
62Tryptophan metabolism_Homo sapiens_hsa003800.38328207
63Homologous recombination_Homo sapiens_hsa034400.37858338
64Regulation of autophagy_Homo sapiens_hsa041400.37213779
65Arachidonic acid metabolism_Homo sapiens_hsa005900.36001175
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35927708
67Lysosome_Homo sapiens_hsa041420.35279790
68Legionellosis_Homo sapiens_hsa051340.34975993
69Fructose and mannose metabolism_Homo sapiens_hsa000510.33851238
70Arginine biosynthesis_Homo sapiens_hsa002200.32964095
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.32937086
72Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.32608822
73Phototransduction_Homo sapiens_hsa047440.32556067
74Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.31692992
75NOD-like receptor signaling pathway_Homo sapiens_hsa046210.30092744
76Metabolic pathways_Homo sapiens_hsa011000.30081445
77Epstein-Barr virus infection_Homo sapiens_hsa051690.29687368
78Glutathione metabolism_Homo sapiens_hsa004800.29254378
79Sulfur relay system_Homo sapiens_hsa041220.26737288
80Ether lipid metabolism_Homo sapiens_hsa005650.26238391
81Huntingtons disease_Homo sapiens_hsa050160.23971443
82RNA degradation_Homo sapiens_hsa030180.23531927
83Cardiac muscle contraction_Homo sapiens_hsa042600.23185304
84Proteasome_Homo sapiens_hsa030500.23146192
85Osteoclast differentiation_Homo sapiens_hsa043800.22428931
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.22015709
87Primary immunodeficiency_Homo sapiens_hsa053400.21688525
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.21504483
89Alzheimers disease_Homo sapiens_hsa050100.21274566
90Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.20919538
91Carbon metabolism_Homo sapiens_hsa012000.20364649
92Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18982016
93Type I diabetes mellitus_Homo sapiens_hsa049400.18890026
94Endometrial cancer_Homo sapiens_hsa052130.18587463
95SNARE interactions in vesicular transport_Homo sapiens_hsa041300.18414801
96Nitrogen metabolism_Homo sapiens_hsa009100.16176306
97Calcium signaling pathway_Homo sapiens_hsa040200.15574995
98Chemical carcinogenesis_Homo sapiens_hsa052040.15018938
99Parkinsons disease_Homo sapiens_hsa050120.14469278
100VEGF signaling pathway_Homo sapiens_hsa043700.13882423
101Insulin resistance_Homo sapiens_hsa049310.13830805
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.13639841
103mTOR signaling pathway_Homo sapiens_hsa041500.13248204
104Basal transcription factors_Homo sapiens_hsa030220.13230652
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.13112782
106RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.12204249
107Prostate cancer_Homo sapiens_hsa052150.11525897
108Hepatitis C_Homo sapiens_hsa051600.10962262
109Cocaine addiction_Homo sapiens_hsa050300.10939356
110NF-kappa B signaling pathway_Homo sapiens_hsa040640.09580828
111Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.09175036
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09083941
113Herpes simplex infection_Homo sapiens_hsa051680.08995759
114Lysine degradation_Homo sapiens_hsa003100.08978590
115Chemokine signaling pathway_Homo sapiens_hsa040620.08939773
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.08796442
117Type II diabetes mellitus_Homo sapiens_hsa049300.08667596
118Staphylococcus aureus infection_Homo sapiens_hsa051500.08435730
119Toll-like receptor signaling pathway_Homo sapiens_hsa046200.08306472
120Vascular smooth muscle contraction_Homo sapiens_hsa042700.08067939
121Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.07919088
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.07790766
123Intestinal immune network for IgA production_Homo sapiens_hsa046720.07693399
124Fatty acid metabolism_Homo sapiens_hsa012120.07644600
125Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.06995799
126Measles_Homo sapiens_hsa051620.06258346
127Thyroid hormone synthesis_Homo sapiens_hsa049180.06231020
128Bile secretion_Homo sapiens_hsa049760.05523186
129Colorectal cancer_Homo sapiens_hsa052100.05244075
130Galactose metabolism_Homo sapiens_hsa000520.05126571
131Peroxisome_Homo sapiens_hsa041460.04925010
132FoxO signaling pathway_Homo sapiens_hsa040680.04203085
133Mismatch repair_Homo sapiens_hsa034300.04124002
134Pyrimidine metabolism_Homo sapiens_hsa002400.03744046
135Hematopoietic cell lineage_Homo sapiens_hsa046400.03250390
136TNF signaling pathway_Homo sapiens_hsa046680.02840766
137Collecting duct acid secretion_Homo sapiens_hsa049660.02604528
138Butanoate metabolism_Homo sapiens_hsa006500.01941362
139Aldosterone synthesis and secretion_Homo sapiens_hsa049250.01781255
140Allograft rejection_Homo sapiens_hsa053300.01731791
141Insulin signaling pathway_Homo sapiens_hsa049100.01548033
142Steroid hormone biosynthesis_Homo sapiens_hsa001400.00672393
143Malaria_Homo sapiens_hsa051440.00587179
144AMPK signaling pathway_Homo sapiens_hsa04152-0.0144638
145Drug metabolism - cytochrome P450_Homo sapiens_hsa00982-0.0132491
146RNA transport_Homo sapiens_hsa03013-0.0057978
147Toxoplasmosis_Homo sapiens_hsa05145-0.0038103
148Bladder cancer_Homo sapiens_hsa05219-0.0033189
149Estrogen signaling pathway_Homo sapiens_hsa04915-0.0026738
150Histidine metabolism_Homo sapiens_hsa00340-0.0015143
151Graft-versus-host disease_Homo sapiens_hsa05332-0.0012981
152T cell receptor signaling pathway_Homo sapiens_hsa04660-0.0009209
153Autoimmune thyroid disease_Homo sapiens_hsa05320-0.0001571

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