CTSC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the peptidase C1 family and lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in cells of the immune system. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate heavy and light chains that form a disulfide-linked dimer. A portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1eosinophil chemotaxis (GO:0048245)7.28100911
2eosinophil migration (GO:0072677)6.59996286
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.17985385
4modulation by symbiont of host immune response (GO:0052553)5.60655479
5positive regulation by symbiont of host defense response (GO:0052509)5.60655479
6modulation by symbiont of host defense response (GO:0052031)5.60655479
7modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.60655479
8modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.60655479
9positive regulation by organism of defense response of other organism involved in symbiotic interact5.60655479
10neutrophil activation involved in immune response (GO:0002283)5.44010486
11response to peptidoglycan (GO:0032494)5.09455015
12positive regulation of interferon-alpha production (GO:0032727)4.71693088
13macrophage activation involved in immune response (GO:0002281)4.63844958
14immunoglobulin mediated immune response (GO:0016064)4.59211275
15regulation of macrophage chemotaxis (GO:0010758)4.56402664
16regulation of interferon-alpha production (GO:0032647)4.48414356
17regulation of interferon-beta biosynthetic process (GO:0045357)4.35903624
18pinocytosis (GO:0006907)4.14501291
19regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.10054206
20respiratory burst (GO:0045730)4.06235611
21microglial cell activation (GO:0001774)4.00203909
22granulocyte activation (GO:0036230)3.99462740
23lipopolysaccharide-mediated signaling pathway (GO:0031663)3.99068765
24neutrophil activation (GO:0042119)3.90485733
25hydrogen peroxide biosynthetic process (GO:0050665)3.83858120
26production of molecular mediator involved in inflammatory response (GO:0002532)3.82215513
27positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.74361948
28response to host immune response (GO:0052572)3.70774348
29response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.70774348
30positive regulation of monocyte chemotaxis (GO:0090026)3.70513657
31positive regulation of cellular amide metabolic process (GO:0034250)3.66762080
32positive regulation of interferon-beta production (GO:0032728)3.58267673
33T-helper 1 type immune response (GO:0042088)3.56653671
34myeloid cell activation involved in immune response (GO:0002275)3.56065246
35antigen processing and presentation of endogenous antigen (GO:0019883)3.54842528
36type I interferon signaling pathway (GO:0060337)3.53614570
37cellular response to type I interferon (GO:0071357)3.53614570
38regulation of hypersensitivity (GO:0002883)3.53369443
39positive regulation of antigen processing and presentation (GO:0002579)3.53154403
40response to type I interferon (GO:0034340)3.50829848
41macrophage activation (GO:0042116)3.48737079
42superoxide anion generation (GO:0042554)3.48353038
43detection of molecule of bacterial origin (GO:0032490)3.46052087
44B cell mediated immunity (GO:0019724)3.45411297
45interferon-gamma-mediated signaling pathway (GO:0060333)3.41150703
46reactive oxygen species biosynthetic process (GO:1903409)3.40987004
47positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.39998539
48positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.39179783
49positive regulation of chemokine biosynthetic process (GO:0045080)3.32519804
50T cell migration (GO:0072678)3.31933725
51response to host (GO:0075136)3.30623260
52response to host defenses (GO:0052200)3.30623260
53response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.30623260
54lymphocyte chemotaxis (GO:0048247)3.28570101
55regulation of mononuclear cell migration (GO:0071675)3.22198258
56response to interferon-alpha (GO:0035455)3.21082005
57regulation of dendritic cell antigen processing and presentation (GO:0002604)3.20983990
58regulation of activation of Janus kinase activity (GO:0010533)3.18533372
59natural killer cell mediated cytotoxicity (GO:0042267)3.18357729
60natural killer cell mediated immunity (GO:0002228)3.18357729
61cellular response to interferon-alpha (GO:0035457)3.16960651
62defense response to protozoan (GO:0042832)3.16777157
63positive regulation of type 2 immune response (GO:0002830)3.15718639
64regulation of B cell receptor signaling pathway (GO:0050855)3.14784430
65positive regulation of mast cell degranulation (GO:0043306)3.13724044
66positive regulation of mast cell activation involved in immune response (GO:0033008)3.13724044
67cellular extravasation (GO:0045123)3.10510245
68virion attachment to host cell (GO:0019062)3.09608156
69adhesion of symbiont to host cell (GO:0044650)3.09608156
70response to muramyl dipeptide (GO:0032495)3.08423106
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.07953024
72regulation of chemokine biosynthetic process (GO:0045073)3.07240764
73negative regulation of interleukin-12 production (GO:0032695)3.06062598
74myeloid dendritic cell differentiation (GO:0043011)3.05446270
75positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610813.02337705
76regulation of monocyte chemotaxis (GO:0090025)3.02139576
77phagocytosis, engulfment (GO:0006911)3.01622182
78positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.01010062
79positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)3.01005925
80regulation of antigen processing and presentation (GO:0002577)3.00394170
81negative regulation of lipid storage (GO:0010888)3.00346507
82antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.00323728
83antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.00323728
84glycosphingolipid catabolic process (GO:0046479)2.99466848
85regulation of mast cell degranulation (GO:0043304)2.99345572
86positive regulation of mast cell activation (GO:0033005)2.99054511
87positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.98972610
88cellular response to exogenous dsRNA (GO:0071360)2.98023812
89positive regulation of gamma-delta T cell activation (GO:0046645)2.97089441
90positive regulation of lymphocyte migration (GO:2000403)2.96407836
91regulation of T cell tolerance induction (GO:0002664)2.94810350
92cellular response to ethanol (GO:0071361)2.94477707
93negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.93433650
94response to interferon-gamma (GO:0034341)2.92109386
95negative regulation of interleukin-17 production (GO:0032700)2.91810688
96positive regulation of interleukin-12 production (GO:0032735)2.91697987
97regulation of tolerance induction (GO:0002643)2.90403565
98myeloid leukocyte activation (GO:0002274)2.90234556
99myeloid dendritic cell activation (GO:0001773)2.89994978
100adhesion of symbiont to host (GO:0044406)2.89598848
101regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.89320978
102detection of other organism (GO:0098543)2.88272060
103regulation of cholesterol storage (GO:0010885)2.87338437
104response to protozoan (GO:0001562)2.86283880
105positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.86178511
106positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.85751008
107amino sugar catabolic process (GO:0046348)2.83887811
108cellular response to interferon-beta (GO:0035458)2.83439091
109positive regulation of chemokine production (GO:0032722)2.82821983
110positive regulation of tumor necrosis factor production (GO:0032760)2.82669689
111monocyte chemotaxis (GO:0002548)2.81868331
112regulation of RIG-I signaling pathway (GO:0039535)2.80507810
113negative regulation of myeloid cell apoptotic process (GO:0033033)2.80406589
114detection of external biotic stimulus (GO:0098581)2.80310327
115positive regulation of T cell migration (GO:2000406)2.79224226
116positive regulation of chemokine secretion (GO:0090197)2.78782499
117leukocyte aggregation (GO:0070486)2.78308537
118regulation of mast cell activation involved in immune response (GO:0033006)2.77234251
119regulation of lymphocyte chemotaxis (GO:1901623)2.76481847
120positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.75781119
121regulation of mast cell activation (GO:0033003)2.75735522
122positive regulation of NF-kappaB import into nucleus (GO:0042346)2.75625426
123positive regulation of leukocyte degranulation (GO:0043302)2.75049909
124cytokine secretion (GO:0050663)2.74724052
125response to xenobiotic stimulus (GO:0009410)2.74283167
126T cell costimulation (GO:0031295)2.74027714
127cellular response to interferon-gamma (GO:0071346)2.73882885
128glycolipid catabolic process (GO:0019377)2.69898524
129lymphocyte costimulation (GO:0031294)2.69427285
130apoptotic cell clearance (GO:0043277)2.68689165
131response to interferon-beta (GO:0035456)2.68199383
132antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.67675636
133regulation of interleukin-2 biosynthetic process (GO:0045076)2.67212606
134phagocytosis, recognition (GO:0006910)2.65977476
135regulation of lymphocyte migration (GO:2000401)2.61800791
136detection of bacterium (GO:0016045)2.61538516
137cellular response to thyroid hormone stimulus (GO:0097067)2.61496528
138regulation of inflammatory response to antigenic stimulus (GO:0002861)2.59240247
139regulation of chemokine secretion (GO:0090196)2.55105596
140peptide catabolic process (GO:0043171)2.54504344
141positive regulation of B cell differentiation (GO:0045579)2.53385696
142barbed-end actin filament capping (GO:0051016)2.49527371
143regulation of myeloid leukocyte mediated immunity (GO:0002886)2.48682910
144negative regulation of viral genome replication (GO:0045071)2.47158605
145membrane raft organization (GO:0031579)2.46234559
146dendritic cell differentiation (GO:0097028)2.44483675
147regulation of granulocyte chemotaxis (GO:0071622)2.44440434
148positive regulation of leukocyte chemotaxis (GO:0002690)2.43466097
149negative regulation of humoral immune response (GO:0002921)2.43126296
150antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.43115574
151granulocyte chemotaxis (GO:0071621)2.42949952
152signal peptide processing (GO:0006465)2.41131597

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.97116848
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.90555136
3BP1_19119308_ChIP-ChIP_Hs578T_Human6.11226572
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.48149523
5IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.23835408
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.95354970
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.93203558
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.56277956
9FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.23139422
10* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.19408645
11* MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.06246715
12RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.89622936
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.83739047
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.76913295
15MYB_21317192_ChIP-Seq_ERMYB_Mouse2.75366220
16STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64825713
17NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.56521268
18STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.52201692
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.43960550
20E2F7_22180533_ChIP-Seq_HELA_Human2.43598398
21* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.42053447
22* SPI1_23547873_ChIP-Seq_NB4_Human2.11229903
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.03471992
24BRD4_27068464_Chip-Seq_AML-cells_Mouse1.95471714
25PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.95219843
26SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.92364625
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78099792
28GATA1_22025678_ChIP-Seq_K562_Human1.75408411
29ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.73099022
30CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.72542602
31EGR1_23403033_ChIP-Seq_LIVER_Mouse1.65952249
32CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65651056
33MYB_26560356_Chip-Seq_TH2_Human1.65516416
34PU_27001747_Chip-Seq_BMDM_Mouse1.58372059
35PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.56659892
36RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.56063884
37RUNX1_22412390_ChIP-Seq_EML_Mouse1.54207294
38VDR_24763502_ChIP-Seq_THP-1_Human1.50119920
39SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.48558404
40ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44700559
41VDR_24787735_ChIP-Seq_THP-1_Human1.41366273
42CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.39972178
43RXR_22158963_ChIP-Seq_LIVER_Mouse1.39707296
44MAF_26560356_Chip-Seq_TH1_Human1.39638927
45THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.38575980
46SPI1_23127762_ChIP-Seq_K562_Human1.38492936
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38086810
48CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.37743327
49PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.37623572
50RUNX_20019798_ChIP-Seq_JUKART_Human1.37228455
51E2F4_17652178_ChIP-ChIP_JURKAT_Human1.36070700
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.35387229
53PPARA_22158963_ChIP-Seq_LIVER_Mouse1.34037432
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.33458957
55SCL_19346495_ChIP-Seq_HPC-7_Human1.31370610
56* MYB_26560356_Chip-Seq_TH1_Human1.30880689
57MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30259325
58KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.27995016
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.27241276
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.27166246
61SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.26523004
62SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.26523004
63LXR_22158963_ChIP-Seq_LIVER_Mouse1.23925022
64GATA3_26560356_Chip-Seq_TH2_Human1.19184760
65NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.18335227
66SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.16340162
67SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16008575
68GABP_17652178_ChIP-ChIP_JURKAT_Human1.15341369
69LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.13113060
70CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.12853420
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10728446
72TP63_17297297_ChIP-ChIP_HaCaT_Human1.10513385
73ELK1_19687146_ChIP-ChIP_HELA_Human1.10301712
74TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.10172660
75GATA2_22383799_ChIP-Seq_G1ME_Mouse1.09562739
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09417922
77EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07632785
78GATA3_27048872_Chip-Seq_THYMUS_Human1.07190933
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.05637584
80FLI1_27457419_Chip-Seq_LIVER_Mouse1.04316078
81HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.02928539
82GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.99908426
83SMAD_19615063_ChIP-ChIP_OVARY_Human0.99164183
84E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.98393488
85LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96625724
86VDR_21846776_ChIP-Seq_THP-1_Human0.94277608
87CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.94176232
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.93722507
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92908948
90PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91568708
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90261769
92FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.85827618
93ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85091425
94CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.84458366
95SOX2_20726797_ChIP-Seq_SW620_Human0.84034169
96UTX_26944678_Chip-Seq_JUKART_Human0.82699712
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80451393
98EGR1_19032775_ChIP-ChIP_M12_Human0.79582654
99SRF_21415370_ChIP-Seq_HL-1_Mouse0.78819734
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.78376934
101VDR_23849224_ChIP-Seq_CD4+_Human0.78288742
102FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.77558361
103* TP63_23658742_ChIP-Seq_EP156T_Human0.77126938
104CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.76573889
105FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.76342058
106* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.76163665
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75156137
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.74734460
109NANOG_18692474_ChIP-Seq_MEFs_Mouse0.74176513
110FOXP3_21729870_ChIP-Seq_TREG_Human0.73439816
111RARG_19884340_ChIP-ChIP_MEFs_Mouse0.72582832
112VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.71273926
113SPI1_20517297_ChIP-Seq_HL60_Human0.69911076
114* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.69677919
115GATA1_19941827_ChIP-Seq_MEL_Mouse0.67893815
116NOTCH1_21737748_ChIP-Seq_TLL_Human0.67660239
117KAP1_22055183_ChIP-Seq_ESCs_Mouse0.67161483
118ELK3_25401928_ChIP-Seq_HUVEC_Human0.66661267
119CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66539045
120* MAF_26560356_Chip-Seq_TH2_Human0.66479568
121HOXB4_20404135_ChIP-ChIP_EML_Mouse0.66437679
122SALL4_18804426_ChIP-ChIP_XEN_Mouse0.64429410
123P63_26484246_Chip-Seq_KERATINOCYTES_Human0.64036631
124GATA2_19941826_ChIP-Seq_K562_Human0.63520099
125TFEB_21752829_ChIP-Seq_HELA_Human0.63444990
126ESR1_21235772_ChIP-Seq_MCF-7_Human0.63256830
127JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.62298011
128ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.62181785
129FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.61467761

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.58692104
2MP0003436_decreased_susceptibility_to3.75342955
3MP0009785_altered_susceptibility_to3.66272495
4MP0002148_abnormal_hypersensitivity_rea3.56846286
5MP0003724_increased_susceptibility_to3.19219228
6MP0005058_abnormal_lysosome_morphology3.16906392
7MP0006082_CNS_inflammation3.14869629
8* MP0002419_abnormal_innate_immunity3.08418559
9MP0005000_abnormal_immune_tolerance2.99584413
10* MP0005025_abnormal_response_to2.83457520
11MP0001790_abnormal_immune_system2.69638280
12MP0005387_immune_system_phenotype2.69638280
13MP0005671_abnormal_response_to2.61713704
14MP0002452_abnormal_antigen_presenting2.54476363
15MP0003303_peritoneal_inflammation2.51534144
16MP0000685_abnormal_immune_system2.50113568
17MP0001800_abnormal_humoral_immune2.46121549
18MP0003191_abnormal_cellular_cholesterol2.45672119
19MP0003806_abnormal_nucleotide_metabolis2.43000585
20* MP0002723_abnormal_immune_serum2.38581628
21MP0009840_abnormal_foam_cell2.33318954
22MP0004782_abnormal_surfactant_physiolog2.27474816
23MP0006054_spinal_hemorrhage2.23336484
24MP0005464_abnormal_platelet_physiology2.08584574
25* MP0001819_abnormal_immune_cell2.08241366
26MP0001533_abnormal_skeleton_physiology2.06795489
27* MP0002420_abnormal_adaptive_immunity2.05399058
28MP0003941_abnormal_skin_development1.99056390
29MP0004510_myositis1.97433900
30MP0009764_decreased_sensitivity_to1.92192503
31MP0001845_abnormal_inflammatory_respons1.88982264
32MP0002405_respiratory_system_inflammati1.85168284
33MP0004947_skin_inflammation1.83739389
34MP0001853_heart_inflammation1.80458250
35* MP0008469_abnormal_protein_level1.76224452
36MP0000569_abnormal_digit_pigmentation1.69350168
37MP0009333_abnormal_splenocyte_physiolog1.67969963
38MP0010155_abnormal_intestine_physiology1.66467084
39MP0000343_altered_response_to1.65628837
40MP0002006_tumorigenesis1.64426672
41MP0005310_abnormal_salivary_gland1.60266281
42MP0003448_altered_tumor_morphology1.57518216
43MP0003172_abnormal_lysosome_physiology1.56922741
44MP0003075_altered_response_to1.56112794
45MP0008057_abnormal_DNA_replication1.50666612
46MP0000716_abnormal_immune_system1.49281866
47MP0003950_abnormal_plasma_membrane1.46683618
48MP0005167_abnormal_blood-brain_barrier1.40403748
49MP0000604_amyloidosis1.39379857
50MP0002998_abnormal_bone_remodeling1.35794157
51MP0002166_altered_tumor_susceptibility1.35124183
52MP0002877_abnormal_melanocyte_morpholog1.34712847
53MP0002398_abnormal_bone_marrow1.32688564
54MP0005166_decreased_susceptibility_to1.29845710
55MP0003690_abnormal_glial_cell1.28026541
56MP0008260_abnormal_autophagy1.25492228
57MP0009278_abnormal_bone_marrow1.25221365
58MP0000858_altered_metastatic_potential1.24220094
59MP0002138_abnormal_hepatobiliary_system1.22399594
60MP0000689_abnormal_spleen_morphology1.20860078
61MP0002277_abnormal_respiratory_mucosa1.20385048
62MP0001545_abnormal_hematopoietic_system1.20324837
63MP0005397_hematopoietic_system_phenotyp1.20324837
64MP0002429_abnormal_blood_cell1.19377477
65MP0010352_gastrointestinal_tract_polyps1.16896370
66MP0005360_urolithiasis1.16602948
67MP0003186_abnormal_redox_activity1.13144282
68MP0008007_abnormal_cellular_replicative1.09781488
69MP0002254_reproductive_system_inflammat1.09551088
70MP0002722_abnormal_immune_system1.09075533
71MP0003828_pulmonary_edema1.08826250
72MP0009763_increased_sensitivity_to1.08498370
73MP0005023_abnormal_wound_healing1.07318410
74MP0005164_abnormal_response_to1.06154578
75MP0005165_increased_susceptibility_to1.01293353
76MP0003300_gastrointestinal_ulcer0.96864260
77MP0005083_abnormal_biliary_tract0.95649299
78MP0005390_skeleton_phenotype0.92122162
79MP0010307_abnormal_tumor_latency0.91881779
80MP0004957_abnormal_blastocyst_morpholog0.89302374
81MP0000249_abnormal_blood_vessel0.87663294
82MP0001849_ear_inflammation0.87586766
83MP0002060_abnormal_skin_morphology0.86609228
84MP0000609_abnormal_liver_physiology0.85075552
85MP0010094_abnormal_chromosome_stability0.83239025
86MP0002139_abnormal_hepatobiliary_system0.83083432
87MP0010234_abnormal_vibrissa_follicle0.81516473
88MP0001851_eye_inflammation0.81421886
89MP0001216_abnormal_epidermal_layer0.81281506
90MP0005076_abnormal_cell_differentiation0.79894842
91MP0003693_abnormal_embryo_hatching0.79640509
92MP0000465_gastrointestinal_hemorrhage0.79571925
93MP0002136_abnormal_kidney_physiology0.78895718
94MP0004883_abnormal_blood_vessel0.78546105
95MP0001958_emphysema0.78250885
96MP0005275_abnormal_skin_tensile0.77629184
97MP0002796_impaired_skin_barrier0.74462185
98MP0003763_abnormal_thymus_physiology0.74157581
99MP0005319_abnormal_enzyme/_coenzyme0.73675461
100MP0004272_abnormal_basement_membrane0.73437797
101MP0003656_abnormal_erythrocyte_physiolo0.73211395
102MP0003566_abnormal_cell_adhesion0.72660548
103MP0002132_abnormal_respiratory_system0.71919819
104MP0000015_abnormal_ear_pigmentation0.71857415
105MP0009765_abnormal_xenobiotic_induced0.71424508
106MP0005451_abnormal_body_composition0.70090523
107MP0000920_abnormal_myelination0.69710095
108MP0004264_abnormal_extraembryonic_tissu0.69467728
109MP0001873_stomach_inflammation0.68900539
110MP0003453_abnormal_keratinocyte_physiol0.68471911
111MP0002933_joint_inflammation0.67752733
112MP0008004_abnormal_stomach_pH0.67593547
113MP0003195_calcinosis0.66257200
114MP0001542_abnormal_bone_strength0.62479515
115MP0003795_abnormal_bone_structure0.61374202
116MP0003183_abnormal_peptide_metabolism0.60549653
117MP0010329_abnormal_lipoprotein_level0.60324833
118MP0002396_abnormal_hematopoietic_system0.59607538
119MP0009643_abnormal_urine_homeostasis0.59041677
120MP0008438_abnormal_cutaneous_collagen0.57659030
121MP0008873_increased_physiological_sensi0.57482810
122MP0000490_abnormal_crypts_of0.57439272
123MP0000598_abnormal_liver_morphology0.56484243
124MP0004808_abnormal_hematopoietic_stem0.55633786
125MP0002295_abnormal_pulmonary_circulatio0.55518949
126MP0000371_diluted_coat_color0.54181852

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.96709546
2* Recurrent abscess formation (HP:0002722)6.64765826
3Recurrent gram-negative bacterial infections (HP:0005420)6.27841870
4* Recurrent bacterial skin infections (HP:0005406)5.94414137
5Systemic lupus erythematosus (HP:0002725)5.82305277
6Abnormality of macrophages (HP:0004311)5.08373734
7Mediastinal lymphadenopathy (HP:0100721)4.58381336
8Vacuolated lymphocytes (HP:0001922)4.56963417
9Autoimmune thrombocytopenia (HP:0001973)4.55366120
10Glomerulonephritis (HP:0000099)4.26929986
11Interstitial pulmonary disease (HP:0006530)4.14533952
12Elevated erythrocyte sedimentation rate (HP:0003565)3.98571240
13Recurrent fungal infections (HP:0002841)3.74780827
14Myositis (HP:0100614)3.73745739
15* Recurrent skin infections (HP:0001581)3.67949210
16Orchitis (HP:0100796)3.65857273
17Chronic obstructive pulmonary disease (HP:0006510)3.62919820
18Obstructive lung disease (HP:0006536)3.62919820
19Increased cerebral lipofuscin (HP:0011813)3.61520480
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.53960240
21Stomatitis (HP:0010280)3.53135575
22Prostate neoplasm (HP:0100787)3.39016319
23Axonal loss (HP:0003447)3.38726725
24Retrobulbar optic neuritis (HP:0100654)3.37616257
25Optic neuritis (HP:0100653)3.37616257
26T lymphocytopenia (HP:0005403)3.36790867
27* Gingivitis (HP:0000230)3.36049775
28Vasculitis (HP:0002633)3.19477869
29Recurrent viral infections (HP:0004429)3.16322741
30Abnormality of liposaccharide metabolism (HP:0010968)3.15900682
31Abnormality of glycosphingolipid metabolism (HP:0004343)3.15900682
32Abnormality of glycolipid metabolism (HP:0010969)3.15900682
33Complement deficiency (HP:0004431)3.14185779
34Abnormality of complement system (HP:0005339)3.13046587
35Increased IgM level (HP:0003496)3.09651897
36Dysostosis multiplex (HP:0000943)3.04062734
37Basal ganglia calcification (HP:0002135)3.02487698
38Nephritis (HP:0000123)2.94797172
39Abnormality of the nasal mucosa (HP:0000433)2.89148258
40Cellulitis (HP:0100658)2.87854204
41Nasal polyposis (HP:0100582)2.82570815
42Recurrent bronchitis (HP:0002837)2.82358153
43Disinhibition (HP:0000734)2.77965375
44Myocardial infarction (HP:0001658)2.76480538
45Urticaria (HP:0001025)2.73966575
46Hematochezia (HP:0002573)2.73720982
47Joint hemorrhage (HP:0005261)2.73539609
48Loss of speech (HP:0002371)2.73439115
49Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.70100731
50Petechiae (HP:0000967)2.69153101
51Recurrent cutaneous fungal infections (HP:0011370)2.66564298
52Chronic mucocutaneous candidiasis (HP:0002728)2.66564298
53Gastrointestinal infarctions (HP:0005244)2.63366875
54Osteomyelitis (HP:0002754)2.59730571
55* Pustule (HP:0200039)2.58000766
56Pulmonary infiltrates (HP:0002113)2.57885487
57Chronic otitis media (HP:0000389)2.56695606
58Recurrent pneumonia (HP:0006532)2.55336443
59Hepatosplenomegaly (HP:0001433)2.55124956
60Meningitis (HP:0001287)2.54027602
61Leukocytosis (HP:0001974)2.49165124
62Spontaneous hematomas (HP:0007420)2.48048197
63* Premature loss of primary teeth (HP:0006323)2.46661582
64Agnosia (HP:0010524)2.39682175
65IgM deficiency (HP:0002850)2.36723853
66Chronic diarrhea (HP:0002028)2.36717353
67Onycholysis (HP:0001806)2.35609600
68Purpura (HP:0000979)2.35118664
69Hypergammaglobulinemia (HP:0010702)2.34857924
70Bronchitis (HP:0012387)2.32550450
71IgA deficiency (HP:0002720)2.32476118
72Gingival bleeding (HP:0000225)2.31869898
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.28742001
74Selective tooth agenesis (HP:0001592)2.27376431
75Abnormality of the prostate (HP:0008775)2.26898225
76Eosinophilia (HP:0001880)2.25236211
77Arterial thrombosis (HP:0004420)2.24337414
78Anorexia (HP:0002039)2.24184388
79Poor head control (HP:0002421)2.22200725
80Recurrent lower respiratory tract infections (HP:0002783)2.22028569
81Prolonged neonatal jaundice (HP:0006579)2.21503278
82Hemoptysis (HP:0002105)2.19383063
83Colitis (HP:0002583)2.18434925
84Keratoconjunctivitis sicca (HP:0001097)2.15796678
85Upper motor neuron abnormality (HP:0002127)2.15335660
86Urinary glycosaminoglycan excretion (HP:0003541)2.15099417
87Mucopolysacchariduria (HP:0008155)2.15099417
88Progressive visual loss (HP:0000529)2.14457021
89Tetraparesis (HP:0002273)2.14338126
90Autoimmune hemolytic anemia (HP:0001890)2.11736374
91Abnormal delayed hypersensitivity skin test (HP:0002963)2.10100247
92Abnormal trabecular bone morphology (HP:0100671)2.07862986
93Xerostomia (HP:0000217)2.04565012
94Mucosal telangiectasiae (HP:0100579)2.01845051
95Epistaxis (HP:0000421)2.01628900
96Joint swelling (HP:0001386)2.01332915
97Amaurosis fugax (HP:0100576)1.99182591
98Conjunctival telangiectasia (HP:0000524)1.98828758
99Abnormality of T cell number (HP:0011839)1.98763254
100* Periodontitis (HP:0000704)1.97631618
101Keratoconjunctivitis (HP:0001096)1.97010416
102Chronic sinusitis (HP:0011109)1.96950305
103Abnormality of polysaccharide metabolism (HP:0011012)1.96721371
104Abnormality of glycosaminoglycan metabolism (HP:0004371)1.96721371
105Abnormality of mucopolysaccharide metabolism (HP:0011020)1.96721371
106Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.95584190
107Milia (HP:0001056)1.95469088
108Bone pain (HP:0002653)1.94181163
109* Thick nail (HP:0001805)1.93731983
110Rough bone trabeculation (HP:0100670)1.92011466
111Malnutrition (HP:0004395)1.91916344
112Pathologic fracture (HP:0002756)1.91585250
113Albinism (HP:0001022)1.91375202
114Cheilitis (HP:0100825)1.91292284
115Nausea (HP:0002018)1.91138717
116Abnormality of eosinophils (HP:0001879)1.90927105
117Abnormality of the basal ganglia (HP:0002134)1.86995307
118Bronchiectasis (HP:0002110)1.86468900
119Agammaglobulinemia (HP:0004432)1.86314522
120Abnormality of T cell physiology (HP:0011840)1.86038635
121Arthralgia (HP:0002829)1.85936687
122Granulocytopenia (HP:0001913)1.84877132
123* Skin ulcer (HP:0200042)1.81830851
124Gangrene (HP:0100758)1.81717999
125Inflammation of the large intestine (HP:0002037)1.81522885
126Pulmonary fibrosis (HP:0002206)1.81008880
127Abnormality of T cells (HP:0002843)1.80743268
128Mutism (HP:0002300)1.80661914
129Increased serum ferritin (HP:0003281)1.80520465
130Personality changes (HP:0000751)1.80284144
131IgG deficiency (HP:0004315)1.77249266
132Abnormality of cells of the lymphoid lineage (HP:0012140)1.76330555

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BLK4.62685787
2MAP3K144.12093509
3RIPK43.92745356
4TYK23.48092596
5IRAK33.19370407
6IRAK43.11077436
7TBK13.05017055
8MAP4K12.69893100
9TXK2.45536194
10IKBKE2.43246738
11JAK32.33482914
12TGFBR22.26738204
13IKBKB2.26730649
14PBK2.26554079
15JAK12.19046444
16ERN12.08298914
17KIT2.07560958
18BUB12.00352877
19FRK1.93418816
20ZAP701.90041402
21NEK91.89890867
22PIM21.76948430
23CSK1.63687570
24STK101.62157338
25TESK21.49873887
26CSF1R1.47080391
27TTK1.45815403
28FGFR41.41790845
29CHUK1.38540768
30SYK1.38424908
31TAOK31.38343404
32GRK71.36913195
33MAP3K131.33780560
34TGFBR11.30895787
35LYN1.30112322
36JAK21.29582200
37NME21.24472272
38RPS6KA41.24377709
39MST41.24178421
40HCK1.24007974
41EIF2AK21.18944524
42TEC1.17335674
43BTK1.17180463
44VRK21.16135344
45MKNK11.14701023
46PIM11.13651645
47ZAK1.09662482
48MATK1.04358538
49EPHB11.00121327
50LCK0.97020871
51CDK190.93527395
52FGR0.93287685
53BMPR20.91309008
54MARK30.88733474
55BRSK20.87508965
56STK40.86035336
57MAP2K30.85597408
58TRIM280.84525117
59FGFR30.84010353
60ABL20.83885251
61MKNK20.83818433
62SMG10.81855767
63NEK10.80629009
64PRKCD0.80289156
65MAP3K30.79287200
66STK30.76263213
67OXSR10.75808041
68MST1R0.75744202
69MYLK0.74272865
70LRRK20.71061548
71ARAF0.70414328
72ITK0.67218760
73TLK10.66945839
74YES10.66473625
75MELK0.66039358
76IRAK10.65814395
77BMX0.64498830
78TAF10.63288931
79CLK10.62026131
80EPHA30.61392905
81ABL10.58943591
82CDC70.58083953
83CAMK1D0.57388075
84MAP3K120.55727845
85EGFR0.55473970
86RIPK10.54447389
87CDK60.53386070
88EIF2AK10.52804076
89MOS0.50305708
90TSSK60.48910660
91PIK3CG0.48852752
92IRAK20.48845867
93SRPK10.48411452
94FES0.46493870
95KDR0.45854294
96PLK30.45447929
97STK240.44729824
98NME10.44568162
99MAP3K50.42820957
100PRKCQ0.42763382
101ACVR1B0.40858063
102ERBB40.40811870
103BMPR1B0.39618701
104INSR0.38842656
105PDK20.38625179
106TRPM70.38545119
107MET0.38439551
108PLK40.38208166
109ADRBK10.38101466
110MAPKAPK20.38092734
111NUAK10.38028737
112FLT30.37587656
113VRK10.37195525
114CDC42BPA0.36562426
115ADRBK20.36530295
116CAMKK20.36512197
117PAK40.32217540
118IGF1R0.30148967
119MAP3K110.29421484
120RPS6KA60.27925668
121CDK40.27601501
122MAPK110.27080624
123PDGFRB0.26149393
124PDK10.25662844
125RAF10.22895426
126PDPK10.20884064
127RPS6KA50.20827676
128EIF2AK30.20069496
129MAP3K80.19583063
130TTN0.19369469
131FYN0.18965826
132MAPK40.18798959
133NLK0.16662375

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.29006155
2Leishmaniasis_Homo sapiens_hsa051403.21849464
3Graft-versus-host disease_Homo sapiens_hsa053323.20981181
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.75114932
5Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.64780677
6Legionellosis_Homo sapiens_hsa051342.64359298
7Allograft rejection_Homo sapiens_hsa053302.57606172
8Pertussis_Homo sapiens_hsa051332.48465167
9NF-kappa B signaling pathway_Homo sapiens_hsa040642.45151508
10Osteoclast differentiation_Homo sapiens_hsa043802.22210331
11Malaria_Homo sapiens_hsa051442.19466215
12* Lysosome_Homo sapiens_hsa041422.16688871
13Tuberculosis_Homo sapiens_hsa051522.16443361
14Rheumatoid arthritis_Homo sapiens_hsa053232.13976093
15NOD-like receptor signaling pathway_Homo sapiens_hsa046212.13701746
16Intestinal immune network for IgA production_Homo sapiens_hsa046722.13414276
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.11722039
18Measles_Homo sapiens_hsa051622.05850181
19RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.97505141
20Influenza A_Homo sapiens_hsa051641.80958165
21Asthma_Homo sapiens_hsa053101.78054408
22Antigen processing and presentation_Homo sapiens_hsa046121.75621020
23Phagosome_Homo sapiens_hsa041451.72310049
24African trypanosomiasis_Homo sapiens_hsa051431.68097226
25Complement and coagulation cascades_Homo sapiens_hsa046101.60638436
26Type I diabetes mellitus_Homo sapiens_hsa049401.60203878
27Other glycan degradation_Homo sapiens_hsa005111.59232396
28TNF signaling pathway_Homo sapiens_hsa046681.55182702
29Herpes simplex infection_Homo sapiens_hsa051681.52043262
30Toxoplasmosis_Homo sapiens_hsa051451.50954207
31Salmonella infection_Homo sapiens_hsa051321.47673724
32Hematopoietic cell lineage_Homo sapiens_hsa046401.47347294
33B cell receptor signaling pathway_Homo sapiens_hsa046621.42237235
34Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42215085
35Glycosaminoglycan degradation_Homo sapiens_hsa005311.40540925
36Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.40431355
37Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23795430
38Systemic lupus erythematosus_Homo sapiens_hsa053221.20496352
39* Apoptosis_Homo sapiens_hsa042101.20223949
40Autoimmune thyroid disease_Homo sapiens_hsa053201.18122101
41Primary immunodeficiency_Homo sapiens_hsa053401.15905146
42Chemokine signaling pathway_Homo sapiens_hsa040621.14348639
43Jak-STAT signaling pathway_Homo sapiens_hsa046301.13964257
44Caffeine metabolism_Homo sapiens_hsa002321.06698502
45Prion diseases_Homo sapiens_hsa050201.05781944
46Glutathione metabolism_Homo sapiens_hsa004800.96860344
47Shigellosis_Homo sapiens_hsa051310.96390875
48Viral myocarditis_Homo sapiens_hsa054160.92453659
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.91364305
50Hepatitis C_Homo sapiens_hsa051600.88862306
51Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86577307
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.85729929
53Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85209927
54Hepatitis B_Homo sapiens_hsa051610.84007573
55Amoebiasis_Homo sapiens_hsa051460.81904341
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.79695135
57AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.77315133
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74520285
59Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72794982
60Non-homologous end-joining_Homo sapiens_hsa034500.70759642
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.69643585
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69537319
63Mismatch repair_Homo sapiens_hsa034300.67588641
64DNA replication_Homo sapiens_hsa030300.65450567
65Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63415809
66N-Glycan biosynthesis_Homo sapiens_hsa005100.63171282
67Vitamin digestion and absorption_Homo sapiens_hsa049770.63083538
68Homologous recombination_Homo sapiens_hsa034400.62232562
69Galactose metabolism_Homo sapiens_hsa000520.62038878
70Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61784657
71Primary bile acid biosynthesis_Homo sapiens_hsa001200.57831511
72Sulfur metabolism_Homo sapiens_hsa009200.57050281
73Epstein-Barr virus infection_Homo sapiens_hsa051690.56128337
74T cell receptor signaling pathway_Homo sapiens_hsa046600.56063339
75Mineral absorption_Homo sapiens_hsa049780.55256929
76Renin-angiotensin system_Homo sapiens_hsa046140.54171887
77Folate biosynthesis_Homo sapiens_hsa007900.50357566
78Proteasome_Homo sapiens_hsa030500.48790095
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.48540046
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.46314882
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.46175958
82Cysteine and methionine metabolism_Homo sapiens_hsa002700.45880864
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.45199974
84Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.44755929
85HTLV-I infection_Homo sapiens_hsa051660.44502044
86Vitamin B6 metabolism_Homo sapiens_hsa007500.43997670
87Acute myeloid leukemia_Homo sapiens_hsa052210.43129622
88Regulation of autophagy_Homo sapiens_hsa041400.41940817
89Platelet activation_Homo sapiens_hsa046110.41596841
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40049359
91Steroid biosynthesis_Homo sapiens_hsa001000.39328912
92Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38925464
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.37852053
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.36775226
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.35705365
96Pentose phosphate pathway_Homo sapiens_hsa000300.35031500
97Ether lipid metabolism_Homo sapiens_hsa005650.34027954
98Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.33881518
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.33850574
100Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.32810593
101Pancreatic cancer_Homo sapiens_hsa052120.31949554
102ABC transporters_Homo sapiens_hsa020100.30873424
103Prolactin signaling pathway_Homo sapiens_hsa049170.29091073
104Chronic myeloid leukemia_Homo sapiens_hsa052200.28923913
105Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.27629390
106Histidine metabolism_Homo sapiens_hsa003400.27343390
107One carbon pool by folate_Homo sapiens_hsa006700.26831037
108HIF-1 signaling pathway_Homo sapiens_hsa040660.26617187
109Selenocompound metabolism_Homo sapiens_hsa004500.25902088
110Small cell lung cancer_Homo sapiens_hsa052220.25797656
111Pyrimidine metabolism_Homo sapiens_hsa002400.25419226
112Sphingolipid metabolism_Homo sapiens_hsa006000.25393370
113Arachidonic acid metabolism_Homo sapiens_hsa005900.25341023
114Transcriptional misregulation in cancer_Homo sapiens_hsa052020.24928911
115Peroxisome_Homo sapiens_hsa041460.24621124
116PPAR signaling pathway_Homo sapiens_hsa033200.21922730
117Viral carcinogenesis_Homo sapiens_hsa052030.21865534
118Collecting duct acid secretion_Homo sapiens_hsa049660.21379916
119SNARE interactions in vesicular transport_Homo sapiens_hsa041300.21199066
120Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.21141397
121Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.21077458
122Fatty acid elongation_Homo sapiens_hsa000620.19972221
123Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.19311740
124Sphingolipid signaling pathway_Homo sapiens_hsa040710.19308863
125p53 signaling pathway_Homo sapiens_hsa041150.17909866
126Insulin resistance_Homo sapiens_hsa049310.17851527
127Arginine biosynthesis_Homo sapiens_hsa002200.14547625

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