CTSE

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the A1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature enzyme. This enzyme, an aspartic endopeptidase, may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1surfactant homeostasis (GO:0043129)7.89405210
2protoporphyrinogen IX metabolic process (GO:0046501)7.86895429
3protoporphyrinogen IX biosynthetic process (GO:0006782)7.58825373
4heme biosynthetic process (GO:0006783)6.98804431
5porphyrin-containing compound biosynthetic process (GO:0006779)6.02734764
6chemical homeostasis within a tissue (GO:0048875)5.93517349
7heme metabolic process (GO:0042168)5.77582880
8calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)5.61239957
9negative regulation of protein activation cascade (GO:2000258)5.41534368
10tetrapyrrole biosynthetic process (GO:0033014)5.34483815
11erythrocyte maturation (GO:0043249)5.26049913
12negative regulation of complement activation (GO:0045916)5.25229651
13porphyrin-containing compound metabolic process (GO:0006778)4.98461628
14maintenance of gastrointestinal epithelium (GO:0030277)4.84895399
15cobalamin metabolic process (GO:0009235)4.68710858
16O-glycan processing (GO:0016266)4.59187500
17telomere maintenance via semi-conservative replication (GO:0032201)4.55621072
18DNA strand elongation involved in DNA replication (GO:0006271)4.50364761
19complement activation, classical pathway (GO:0006958)4.38503432
20DNA replication initiation (GO:0006270)4.32165451
21ribosomal small subunit assembly (GO:0000028)4.29828569
22DNA strand elongation (GO:0022616)4.28752518
23regulation of cholesterol esterification (GO:0010872)4.24635885
24phospholipid efflux (GO:0033700)4.24292066
25* digestion (GO:0007586)4.23561566
26one-carbon compound transport (GO:0019755)4.20165274
27negative regulation of humoral immune response (GO:0002921)4.17788670
28intestinal absorption (GO:0050892)4.15232140
29negative regulation of transcription by competitive promoter binding (GO:0010944)4.12542730
30bundle of His cell to Purkinje myocyte communication (GO:0086069)4.08899350
31deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.98049130
32erythrocyte development (GO:0048821)3.97707480
33DNA replication checkpoint (GO:0000076)3.92758584
34plasma lipoprotein particle assembly (GO:0034377)3.87657948
35lung secretory cell differentiation (GO:0061140)3.83811319
36telomere maintenance via recombination (GO:0000722)3.82797415
37DNA deamination (GO:0045006)3.79733807
38regulation of transforming growth factor beta1 production (GO:0032908)3.78043932
39positive regulation of Rho protein signal transduction (GO:0035025)3.77084684
40regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.76694958
41intestinal cholesterol absorption (GO:0030299)3.69979297
42complement activation (GO:0006956)3.66731213
43viral transcription (GO:0019083)3.61683599
44protein-lipid complex assembly (GO:0065005)3.54685161
45peptide catabolic process (GO:0043171)3.51005266
46positive regulation of gamma-delta T cell activation (GO:0046645)3.50619289
47DNA unwinding involved in DNA replication (GO:0006268)3.47647031
48tetrapyrrole metabolic process (GO:0033013)3.47643850
49translational termination (GO:0006415)3.47040632
50glomerular filtration (GO:0003094)3.41521878
51epithelial structure maintenance (GO:0010669)3.41115914
52mitotic recombination (GO:0006312)3.40383024
53retinal metabolic process (GO:0042574)3.38945723
54progesterone metabolic process (GO:0042448)3.35276486
55very-low-density lipoprotein particle assembly (GO:0034379)3.34820856
56antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.34145041
57antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.34145041
58fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.33736295
59Golgi transport vesicle coating (GO:0048200)3.33697319
60COPI coating of Golgi vesicle (GO:0048205)3.33697319
61renal filtration (GO:0097205)3.33233683
62folic acid-containing compound biosynthetic process (GO:0009396)3.31741806
63positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.31111203
64regulation of cytokine secretion involved in immune response (GO:0002739)3.28933178
65tight junction assembly (GO:0070830)3.28281873
66high-density lipoprotein particle remodeling (GO:0034375)3.26561829
67keratan sulfate catabolic process (GO:0042340)3.24682544
68pigment biosynthetic process (GO:0046148)3.19739958
69translational elongation (GO:0006414)3.17693689
70digestive system process (GO:0022600)3.16145206
71positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.14274538
72telomere maintenance via telomere lengthening (GO:0010833)3.14151938
73glucuronate metabolic process (GO:0019585)3.13193306
74uronic acid metabolic process (GO:0006063)3.13193306
75CENP-A containing nucleosome assembly (GO:0034080)3.12642179
76deoxyribonucleotide biosynthetic process (GO:0009263)3.12472548
77SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.10413718
78protein activation cascade (GO:0072376)3.10136112
79protein O-linked glycosylation (GO:0006493)3.09076704
80regulation of complement activation (GO:0030449)3.08788251
81regulation of protein activation cascade (GO:2000257)3.08203029
82transcytosis (GO:0045056)3.08043166
83positive regulation of substrate adhesion-dependent cell spreading (GO:1900026)3.05525942
84regulation of heterotypic cell-cell adhesion (GO:0034114)3.04349106
85cotranslational protein targeting to membrane (GO:0006613)3.01306083
86protein targeting to ER (GO:0045047)3.00959572
87gas transport (GO:0015669)3.00555346
88regulation of metalloenzyme activity (GO:0048552)2.99009599
89antigen processing and presentation of endogenous antigen (GO:0019883)2.98838599
90nucleotide-excision repair, DNA gap filling (GO:0006297)2.98628317
91sulfate transmembrane transport (GO:1902358)2.98344526
92protein localization to chromosome, centromeric region (GO:0071459)2.98001770
93cellular glucuronidation (GO:0052695)2.97967417
94positive regulation of insulin receptor signaling pathway (GO:0046628)2.97064103
95embryonic hemopoiesis (GO:0035162)2.95741081
96sodium ion homeostasis (GO:0055078)2.94345364
972-deoxyribonucleotide biosynthetic process (GO:0009265)2.93789092
98deoxyribose phosphate biosynthetic process (GO:0046385)2.93789092
99phospholipid homeostasis (GO:0055091)2.92654382
100chromatin remodeling at centromere (GO:0031055)2.91999303
101COPII vesicle coating (GO:0048208)2.91245312
102intestinal epithelial cell development (GO:0060576)2.90481440
103bile acid metabolic process (GO:0008206)2.89978008
104peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.89657294
105DNA replication-independent nucleosome organization (GO:0034724)2.88794881
106DNA replication-independent nucleosome assembly (GO:0006336)2.88794881
107renal absorption (GO:0070293)2.88315867
108cell adhesion mediated by integrin (GO:0033627)2.87933798
109protein localization to endoplasmic reticulum (GO:0070972)2.87650852
110protein localization to kinetochore (GO:0034501)2.85483428
111erythrocyte differentiation (GO:0030218)2.84277851
112establishment of protein localization to endoplasmic reticulum (GO:0072599)2.84271437
113pigment metabolic process (GO:0042440)2.83320131
114lysine metabolic process (GO:0006553)2.82564029
115lysine catabolic process (GO:0006554)2.82564029
116positive regulation of granulocyte differentiation (GO:0030854)2.82112881
117negative regulation of gluconeogenesis (GO:0045721)2.81927618
118phosphate ion transmembrane transport (GO:0035435)2.81920922
119myeloid cell development (GO:0061515)2.80502320
120positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.77726789
121cholesterol efflux (GO:0033344)2.77684397
122regulation of gamma-delta T cell differentiation (GO:0045586)2.77676442
123regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.77480899
124C21-steroid hormone metabolic process (GO:0008207)2.76671860
125nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.76346319
126daunorubicin metabolic process (GO:0044597)2.76261994
127polyketide metabolic process (GO:0030638)2.76261994
128doxorubicin metabolic process (GO:0044598)2.76261994
129oligosaccharide biosynthetic process (GO:0009312)2.74121909
130regulation of erythrocyte differentiation (GO:0045646)2.71587746
131translational initiation (GO:0006413)2.70107163
132kinetochore organization (GO:0051383)2.69987503
133viral life cycle (GO:0019058)2.68783758
134DNA replication-dependent nucleosome assembly (GO:0006335)2.68733195
135DNA replication-dependent nucleosome organization (GO:0034723)2.68733195
136regulation of proton transport (GO:0010155)2.68218119
137reverse cholesterol transport (GO:0043691)2.68170316
138regulation of digestive system process (GO:0044058)2.67970876
139ribosomal small subunit biogenesis (GO:0042274)2.67677385
140positive regulation of B cell differentiation (GO:0045579)2.65698163
141antibacterial humoral response (GO:0019731)2.63161345
142lipoprotein metabolic process (GO:0042157)2.62470716
143positive regulation of pseudopodium assembly (GO:0031274)2.62461081
144lung vasculature development (GO:0060426)2.61548140
145cellular protein complex disassembly (GO:0043624)2.59951939
146lipoprotein transport (GO:0042953)2.58575409
147trivalent inorganic anion homeostasis (GO:0072506)2.57007118
148phosphate ion homeostasis (GO:0055062)2.57007118
149cellular response to reactive nitrogen species (GO:1902170)2.56461758
150antimicrobial humoral response (GO:0019730)2.56077686
151negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)2.54637965
152membrane budding (GO:0006900)2.53649989
153regulation of transforming growth factor beta2 production (GO:0032909)2.53395380
154regulation of cellular extravasation (GO:0002691)2.53052423
155production of molecular mediator of immune response (GO:0002440)2.52103679
156vitamin transport (GO:0051180)2.51169872
157iron-sulfur cluster assembly (GO:0016226)2.50389510
158metallo-sulfur cluster assembly (GO:0031163)2.50389510
159regulation of substrate adhesion-dependent cell spreading (GO:1900024)2.49618370
160sterol transport (GO:0015918)2.48510660
161cholesterol transport (GO:0030301)2.48510660
162positive regulation of erythrocyte differentiation (GO:0045648)2.48322035
163antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.47687775
164pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.46959739
165translesion synthesis (GO:0019985)2.46895726
166positive regulation of tyrosine phosphorylation of Stat1 protein (GO:0042511)2.46494337
167formation of translation preinitiation complex (GO:0001731)2.46050425
168maturation of SSU-rRNA (GO:0030490)2.45782097
169meiotic chromosome segregation (GO:0045132)2.45534391
170negative regulation of RNA splicing (GO:0033119)2.45141491
171regulation of gamma-delta T cell activation (GO:0046643)2.45087884
172bicarbonate transport (GO:0015701)2.44920869
173negative regulation of lipase activity (GO:0060192)2.44809519
174regulation of transforming growth factor beta production (GO:0071634)2.44149931
175regulation of cholesterol homeostasis (GO:2000188)2.43772308
176Arp2/3 complex-mediated actin nucleation (GO:0034314)2.43729059
177bile acid and bile salt transport (GO:0015721)2.43435078
178folic acid metabolic process (GO:0046655)2.43402900
179negative regulation of digestive system process (GO:0060457)2.43401692
180telomere maintenance (GO:0000723)2.42108062
181telomere organization (GO:0032200)2.42001865
182regulation of integrin-mediated signaling pathway (GO:2001044)2.41290371
183desmosome organization (GO:0002934)2.40622459
184regulation of chemokine secretion (GO:0090196)2.40530297
185aminoglycoside antibiotic metabolic process (GO:0030647)2.39609289
186response to iron ion (GO:0010039)2.37875585
187mitotic nuclear envelope disassembly (GO:0007077)2.37743625
188response to arsenic-containing substance (GO:0046685)2.37241349
189regulation of tumor necrosis factor-mediated signaling pathway (GO:0010803)2.36621224
190pentose-phosphate shunt (GO:0006098)2.36618114
191regulation of protein heterodimerization activity (GO:0043497)2.35107326
192positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.35091285
193chromatin assembly or disassembly (GO:0006333)2.33082641
194pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.32183094
195response to lead ion (GO:0010288)2.31436112

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14423486
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.62657661
3CDX2_20551321_ChIP-Seq_CACO-2_Human4.10106603
4TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.33262865
5FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human3.32908295
6SMAD4_19686287_ChIP-ChIP_HaCaT_Human3.16558774
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.02370574
8E2F4_17652178_ChIP-ChIP_JURKAT_Human3.01100399
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.88164537
10SOX2_27498859_Chip-Seq_STOMACH_Mouse2.87212010
11SOX2_20726797_ChIP-Seq_SW620_Human2.70992232
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.70363084
13* GATA4_25053715_ChIP-Seq_YYC3_Human2.66083074
14GATA1_22025678_ChIP-Seq_K562_Human2.55335443
15* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.46736807
16IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.44745811
17* GATA6_25053715_ChIP-Seq_YYC3_Human2.39863648
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.39682444
19TP63_17297297_ChIP-ChIP_HaCaT_Human2.39492646
20SCL_19346495_ChIP-Seq_HPC-7_Human2.35116528
21RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.31972232
22CDX2_19796622_ChIP-Seq_MESCs_Mouse2.27411512
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.26348980
24TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.26132276
25PPAR_26484153_Chip-Seq_NCI-H1993_Human2.22986275
26LXR_22158963_ChIP-Seq_LIVER_Mouse2.17464881
27IRF8_22096565_ChIP-ChIP_GC-B_Human2.12845720
28ESR2_21235772_ChIP-Seq_MCF-7_Human2.11553663
29MYC_22102868_ChIP-Seq_BL_Human2.09375313
30KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08322609
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.08041073
32* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07465005
33ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.06176655
34FOXO3_23340844_ChIP-Seq_DLD1_Human2.05251198
35* TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.04254929
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.01649079
37TCF4_18268006_ChIP-ChIP_LS174T_Human2.01556121
38ZNF217_24962896_ChIP-Seq_MCF-7_Human1.96345803
39* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.94557555
40RXR_22158963_ChIP-Seq_LIVER_Mouse1.93809157
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.92871510
42SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92610675
43GABP_17652178_ChIP-ChIP_JURKAT_Human1.91242019
44* GATA1_19941827_ChIP-Seq_MEL_Mouse1.88445625
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.88004162
46SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86254273
47GATA2_21666600_ChIP-Seq_HMVEC_Human1.85702547
48EST1_17652178_ChIP-ChIP_JURKAT_Human1.83202676
49VDR_21846776_ChIP-Seq_THP-1_Human1.81716915
50TRIM28_21343339_ChIP-Seq_HEK293_Human1.79692754
51VDR_23849224_ChIP-Seq_CD4+_Human1.77585919
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.77107666
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.76136235
54ETS1_20019798_ChIP-Seq_JURKAT_Human1.71525415
55MYC_19030024_ChIP-ChIP_MESCs_Mouse1.70165569
56SMAD_19615063_ChIP-ChIP_OVARY_Human1.67936591
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.67293471
58AR_21909140_ChIP-Seq_LNCAP_Human1.66474914
59AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.65768992
60SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65638980
61CJUN_26792858_Chip-Seq_BT549_Human1.65043766
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.64767437
63ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.64170421
64ERG_20887958_ChIP-Seq_HPC-7_Mouse1.63683357
65CREB1_15753290_ChIP-ChIP_HEK293T_Human1.61458307
66* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.61112610
67NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.58533417
68PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.57621090
69* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.56794304
70FOXM1_26456572_ChIP-Seq_MCF-7_Human1.56488924
71* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.56174378
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.56061449
73Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.55683485
74RARG_19884340_ChIP-ChIP_MEFs_Mouse1.52197259
75MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51861671
76FOXP3_21729870_ChIP-Seq_TREG_Human1.50539009
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.50233230
78GATA1_19941826_ChIP-Seq_K562_Human1.49775848
79FOXA2_19822575_ChIP-Seq_HepG2_Human1.49241386
80XRN2_22483619_ChIP-Seq_HELA_Human1.48311918
81RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.47787345
82SPI1_23547873_ChIP-Seq_NB4_Human1.46255173
83AHR_22903824_ChIP-Seq_MCF-7_Human1.46101001
84STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.45801342
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.45736762
86ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.44305684
87IRF8_21731497_ChIP-ChIP_J774_Mouse1.44262121
88MYB_26560356_Chip-Seq_TH2_Human1.44132847
89DCP1A_22483619_ChIP-Seq_HELA_Human1.43606593
90SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.42868527
91TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41819009
92SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.41690849
93SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.41690849
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.40929734
95* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.40373724
96RUNX1_22412390_ChIP-Seq_EML_Mouse1.39258446
97ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.38738050
98NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38725812
99STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37535478
100CDX2_22108803_ChIP-Seq_LS180_Human1.37405223
101KLF5_25053715_ChIP-Seq_YYC3_Human1.37313579
102MAF_26560356_Chip-Seq_TH1_Human1.36977952
103CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33988431
104* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.32421594
105E2F1_18555785_ChIP-Seq_MESCs_Mouse1.32274233
106BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.31887029
107ESR1_20079471_ChIP-ChIP_T-47D_Human1.31740045
108CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.31459728
109CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.31210174
110EGR1_19374776_ChIP-ChIP_THP-1_Human1.31053603
111SRF_21415370_ChIP-Seq_HL-1_Mouse1.30650493
112HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.30489118
113MYB_26560356_Chip-Seq_TH1_Human1.30197997
114GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29726366
115GABP_19822575_ChIP-Seq_HepG2_Human1.29126827
116FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.28952804
117* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.28667931
118ESR1_15608294_ChIP-ChIP_MCF-7_Human1.26101679
119GATA3_24758297_ChIP-Seq_MCF-7_Human1.26018845
120KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.25109487
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24836107
122UTX_26944678_Chip-Seq_JUKART_Human1.24643533
123EGR1_23403033_ChIP-Seq_LIVER_Mouse1.24169221
124CLOCK_20551151_ChIP-Seq_293T_Human1.23342061
125SMAD3_21741376_ChIP-Seq_HESCs_Human1.23090511
126GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22480724
127FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21042755
128PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.19290750
129CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19288480
130PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.18450497
131EP300_21415370_ChIP-Seq_HL-1_Mouse1.18330644
132* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.17225000
133FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15184163
134NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14468240
135FOXA1_25552417_ChIP-Seq_VCAP_Human1.13223686
136MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.13220483
137KDM5A_27292631_Chip-Seq_BREAST_Human1.12557152
138CIITA_25753668_ChIP-Seq_RAJI_Human1.12044561
139ARNT_22903824_ChIP-Seq_MCF-7_Human1.11921868
140HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.11389737
141NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11313199
142NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11313199
143ELK1_19687146_ChIP-ChIP_HELA_Human1.11306676
144VDR_24763502_ChIP-Seq_THP-1_Human1.10518763
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10237935
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09350029
147NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.09047709
148* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.09018136
149PPARA_22158963_ChIP-Seq_LIVER_Mouse1.08613314
150TP63_23658742_ChIP-Seq_EP156T_Human1.08593324
151CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.07362582
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06267208
153PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.06159674
154HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.05644569
155SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05635194
156ZFX_18555785_ChIP-Seq_MESCs_Mouse1.04446512
157NOTCH1_21737748_ChIP-Seq_TLL_Human1.04298958
158TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.03112517
159E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02374546
160* IRF8_27001747_Chip-Seq_BMDM_Mouse1.02226980
161P63_26484246_Chip-Seq_KERATINOCYTES_Human1.01169852
162* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.00640175
163THAP11_20581084_ChIP-Seq_MESCs_Mouse1.00174061
164CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99450605
165TTF2_22483619_ChIP-Seq_HELA_Human0.98339839
166SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98124895
167MAF_26560356_Chip-Seq_TH2_Human0.97581578
168MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97456055
169MYCN_18555785_ChIP-Seq_MESCs_Mouse0.97017315
170PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95588104
171E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.95349226
172AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.94949676
173CTNNB1_20460455_ChIP-Seq_HCT116_Human0.93940817
174SOX9_24532713_ChIP-Seq_HFSC_Mouse0.93700962
175CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93442907
176STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.92379564
177RUNX1_27514584_Chip-Seq_MCF-7_Human0.91970730
178TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.89904281
179JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.88676809
180BCAT_22108803_ChIP-Seq_LS180_Human0.88297136
181EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86209493
182HNF4A_19822575_ChIP-Seq_HepG2_Human0.85615157
183RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85371313
184SMAD4_21741376_ChIP-Seq_HESCs_Human0.85275446
185JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84775599
186GATA2_19941826_ChIP-Seq_K562_Human0.84619452
187HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84590922
188SUZ12_27294783_Chip-Seq_NPCs_Mouse0.82846209
189FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.80261029
190CEBPB_22108803_ChIP-Seq_LS180_Human0.79572995
191TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.79215668

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008004_abnormal_stomach_pH6.36784221
2MP0003656_abnormal_erythrocyte_physiolo5.94798732
3MP0004147_increased_porphyrin_level5.23153136
4MP0006054_spinal_hemorrhage4.37244119
5MP0004782_abnormal_surfactant_physiolog3.46619972
6MP0003806_abnormal_nucleotide_metabolis3.40736459
7MP0009840_abnormal_foam_cell3.35579925
8MP0001873_stomach_inflammation3.32155078
9MP0002396_abnormal_hematopoietic_system2.71068428
10MP0001545_abnormal_hematopoietic_system2.61141717
11MP0005397_hematopoietic_system_phenotyp2.61141717
12MP0003693_abnormal_embryo_hatching2.35856991
13MP0000490_abnormal_crypts_of2.23581204
14MP0001958_emphysema2.21385931
15MP0010094_abnormal_chromosome_stability2.10458278
16MP0005275_abnormal_skin_tensile2.07967220
17MP0005671_abnormal_response_to2.07143276
18MP0008057_abnormal_DNA_replication2.05415325
19MP0005165_increased_susceptibility_to1.94824783
20MP0003111_abnormal_nucleus_morphology1.90337449
21MP0000685_abnormal_immune_system1.88494840
22MP0004957_abnormal_blastocyst_morpholog1.88276233
23MP0001835_abnormal_antigen_presentation1.87051361
24* MP0002398_abnormal_bone_marrow1.86703629
25MP0009333_abnormal_splenocyte_physiolog1.83755097
26MP0003186_abnormal_redox_activity1.83068846
27MP0003763_abnormal_thymus_physiology1.81699788
28MP0003077_abnormal_cell_cycle1.70263649
29MP0000689_abnormal_spleen_morphology1.62686441
30MP0003724_increased_susceptibility_to1.61283626
31MP0000470_abnormal_stomach_morphology1.60612879
32MP0001664_abnormal_digestion1.60168001
33MP0002722_abnormal_immune_system1.60013327
34* MP0001800_abnormal_humoral_immune1.57967693
35MP0001663_abnormal_digestive_system1.57593572
36MP0008438_abnormal_cutaneous_collagen1.56232306
37MP0002132_abnormal_respiratory_system1.55287118
38MP0005166_decreased_susceptibility_to1.54395655
39MP0009785_altered_susceptibility_to1.50671280
40MP0005025_abnormal_response_to1.49062126
41MP0010386_abnormal_urinary_bladder1.48424273
42MP0002139_abnormal_hepatobiliary_system1.47732313
43MP0005464_abnormal_platelet_physiology1.47358413
44MP0005023_abnormal_wound_healing1.46819607
45MP0002166_altered_tumor_susceptibility1.45394093
46* MP0002429_abnormal_blood_cell1.44753908
47MP0005636_abnormal_mineral_homeostasis1.44480921
48MP0001853_heart_inflammation1.42988245
49MP0002138_abnormal_hepatobiliary_system1.40728338
50* MP0002420_abnormal_adaptive_immunity1.39449328
51* MP0002452_abnormal_antigen_presenting1.38890539
52* MP0000716_abnormal_immune_system1.37625751
53* MP0001819_abnormal_immune_cell1.36407059
54MP0004019_abnormal_vitamin_homeostasis1.35955492
55MP0010155_abnormal_intestine_physiology1.35722579
56MP0001666_abnormal_nutrient_absorption1.35576209
57MP0004808_abnormal_hematopoietic_stem1.35543836
58MP0003436_decreased_susceptibility_to1.34967184
59MP0005503_abnormal_tendon_morphology1.32391726
60MP0002019_abnormal_tumor_incidence1.32231641
61MP0008058_abnormal_DNA_repair1.31177479
62MP0002876_abnormal_thyroid_physiology1.29512002
63MP0005000_abnormal_immune_tolerance1.28584349
64MP0002405_respiratory_system_inflammati1.28225470
65* MP0002723_abnormal_immune_serum1.27515643
66MP0000703_abnormal_thymus_morphology1.23883719
67MP0000462_abnormal_digestive_system1.22567262
68MP0004043_abnormal_pH_regulation1.21901862
69MP0006036_abnormal_mitochondrial_physio1.20316349
70MP0004272_abnormal_basement_membrane1.18214791
71MP0005164_abnormal_response_to1.18054723
72MP0005083_abnormal_biliary_tract1.17577649
73MP0003866_abnormal_defecation1.17534872
74MP0005085_abnormal_gallbladder_physiolo1.16784905
75MP0002419_abnormal_innate_immunity1.16279287
76MP0010352_gastrointestinal_tract_polyps1.14906860
77MP0001845_abnormal_inflammatory_respons1.11096428
78MP0001790_abnormal_immune_system1.09821358
79MP0005387_immune_system_phenotype1.09821358
80MP0000477_abnormal_intestine_morphology1.08644197
81MP0003252_abnormal_bile_duct1.08399937
82MP0005381_digestive/alimentary_phenotyp1.07539866
83MP0002006_tumorigenesis1.07308150
84MP0000465_gastrointestinal_hemorrhage1.07210623
85MP0005360_urolithiasis1.06335834
86MP0001756_abnormal_urination1.03688238
87MP0004883_abnormal_blood_vessel1.02319195
88* MP0008469_abnormal_protein_level1.02141816
89MP0003566_abnormal_cell_adhesion1.00162186
90MP0010307_abnormal_tumor_latency1.00053013
91MP0002133_abnormal_respiratory_system0.98686641
92MP0005388_respiratory_system_phenotype0.98686641
93MP0009764_decreased_sensitivity_to0.96890514
94MP0000609_abnormal_liver_physiology0.94965091
95MP0000537_abnormal_urethra_morphology0.94149805
96MP0010678_abnormal_skin_adnexa0.91727988
97MP0010234_abnormal_vibrissa_follicle0.90450706
98MP0000858_altered_metastatic_potential0.88913985
99MP0002148_abnormal_hypersensitivity_rea0.87921090
100MP0008007_abnormal_cellular_replicative0.87684484
101MP0000313_abnormal_cell_death0.84793645
102MP0002136_abnormal_kidney_physiology0.84662225
103MP0003091_abnormal_cell_migration0.84492430
104MP0008875_abnormal_xenobiotic_pharmacok0.83055382
105MP0002118_abnormal_lipid_homeostasis0.83048576
106MP0004484_altered_response_of0.82780100
107MP0003453_abnormal_keratinocyte_physiol0.80570850
108MP0003300_gastrointestinal_ulcer0.80350810
109MP0006082_CNS_inflammation0.78548337
110MP0000249_abnormal_blood_vessel0.78541284
111MP0005670_abnormal_white_adipose0.76821732
112MP0003191_abnormal_cellular_cholesterol0.76561654
113MP0000598_abnormal_liver_morphology0.76095120
114MP0003303_peritoneal_inflammation0.75887899
115MP0005319_abnormal_enzyme/_coenzyme0.75659405
116MP0005584_abnormal_enzyme/coenzyme_acti0.75338206
117MP0000350_abnormal_cell_proliferation0.73721387
118MP0009278_abnormal_bone_marrow0.73376539
119* MP0004947_skin_inflammation0.72373994
120MP0005365_abnormal_bile_salt0.71459402
121MP0010329_abnormal_lipoprotein_level0.69414267
122MP0001986_abnormal_taste_sensitivity0.68691789
123MP0003045_fibrosis0.68450910
124MP0004264_abnormal_extraembryonic_tissu0.67840490
125MP0000613_abnormal_salivary_gland0.67545919
126MP0003950_abnormal_plasma_membrane0.65227866
127MP0002796_impaired_skin_barrier0.65011108
128MP0000343_altered_response_to0.64981193
129MP0005408_hypopigmentation0.63433234
130MP0003868_abnormal_feces_composition0.63040385
131MP0001764_abnormal_homeostasis0.62603532
132MP0000516_abnormal_urinary_system0.62274198
133MP0005367_renal/urinary_system_phenotyp0.62274198
134* MP0009931_abnormal_skin_appearance0.61961649
135MP0001730_embryonic_growth_arrest0.61842545
136MP0005332_abnormal_amino_acid0.61831913
137MP0005075_abnormal_melanosome_morpholog0.61670942
138MP0009763_increased_sensitivity_to0.59547293
139MP0005501_abnormal_skin_physiology0.59113447
140MP0009643_abnormal_urine_homeostasis0.58417038
141MP0005266_abnormal_metabolism0.58344609
142MP0004215_abnormal_myocardial_fiber0.58104802
143MP0001542_abnormal_bone_strength0.57537907
144MP0010368_abnormal_lymphatic_system0.56734869
145MP0005058_abnormal_lysosome_morphology0.56593607
146MP0002098_abnormal_vibrissa_morphology0.56469139
147MP0003075_altered_response_to0.55690071
148MP0002060_abnormal_skin_morphology0.55027779
149MP0001765_abnormal_ion_homeostasis0.55017213
150MP0000538_abnormal_urinary_bladder0.53590827
151MP0003448_altered_tumor_morphology0.53074417
152MP0001533_abnormal_skeleton_physiology0.52462402
153MP0008872_abnormal_physiological_respon0.50828580

Predicted human phenotypes

RankGene SetZ-score
1Abnormal number of erythroid precursors (HP:0012131)8.43733435
2Abnormality of cells of the erythroid lineage (HP:0012130)7.80646293
3Interstitial pulmonary disease (HP:0006530)6.30446784
4Poikilocytosis (HP:0004447)5.99340669
5Hyperactive renin-angiotensin system (HP:0000841)5.48786133
6Right ventricular cardiomyopathy (HP:0011663)4.68958543
7Birth length less than 3rd percentile (HP:0003561)4.55756813
8Acanthocytosis (HP:0001927)4.49603065
9Reticulocytosis (HP:0001923)4.44755901
10Fat malabsorption (HP:0002630)4.31486341
11Malnutrition (HP:0004395)4.25570832
12Systemic lupus erythematosus (HP:0002725)4.03449963
13Abnormality of the vitamin B12 metabolism (HP:0004341)4.01895763
14Gout (HP:0001997)3.95164584
15Hyperbilirubinemia (HP:0002904)3.86239311
16Abnormality of vitamin B metabolism (HP:0004340)3.86070349
17Increased serum ferritin (HP:0003281)3.79999202
18Intrahepatic cholestasis (HP:0001406)3.78397501
19Steatorrhea (HP:0002570)3.77232173
20Abnormality of reticulocytes (HP:0004312)3.73598323
21Tubulointerstitial nephritis (HP:0001970)3.66395805
22Abnormality of chloride homeostasis (HP:0011422)3.60053494
23Petechiae (HP:0000967)3.57934651
24Abnormality of vitamin metabolism (HP:0100508)3.49433423
25Abnormality of iron homeostasis (HP:0011031)3.47279916
26Amyloidosis (HP:0011034)3.38781724
27Renal salt wasting (HP:0000127)3.37228146
28Spontaneous abortion (HP:0005268)3.35031891
29Glomerulonephritis (HP:0000099)3.34094765
30Abnormality of transition element cation homeostasis (HP:0011030)3.24527919
31Conjugated hyperbilirubinemia (HP:0002908)3.24520452
32Tubulointerstitial fibrosis (HP:0005576)3.19772677
33Prolonged bleeding time (HP:0003010)3.18693451
34Abnormality of monocarboxylic acid metabolism (HP:0010996)2.97369485
35Diaphragmatic weakness (HP:0009113)2.95604198
36Decreased circulating renin level (HP:0003351)2.93059051
37Pallor (HP:0000980)2.90913216
38Glomerulosclerosis (HP:0000096)2.90059923
39IgM deficiency (HP:0002850)2.86823446
40Abnormal biliary tract morphology (HP:0012440)2.83707540
41Flat acetabular roof (HP:0003180)2.82966656
42Osteolytic defects of the hand bones (HP:0009699)2.77138162
43Osteolytic defects of the phalanges of the hand (HP:0009771)2.77138162
44Macrocytic anemia (HP:0001972)2.76824263
45Abnormality of renin-angiotensin system (HP:0000847)2.73430172
46Hyperaldosteronism (HP:0000859)2.71233764
47Abnormal pancreas size (HP:0012094)2.70915793
48Cholelithiasis (HP:0001081)2.68042941
49Epistaxis (HP:0000421)2.68015167
50Complement deficiency (HP:0004431)2.67932090
51Aortic dissection (HP:0002647)2.65099701
52Aplastic anemia (HP:0001915)2.61845692
53Recurrent viral infections (HP:0004429)2.59962879
54Abnormality of glutamine family amino acid metabolism (HP:0010902)2.59613578
55Abnormality of complement system (HP:0005339)2.56964405
56Cutaneous photosensitivity (HP:0000992)2.56297766
57Nephritis (HP:0000123)2.56097721
58Aortic aneurysm (HP:0004942)2.55939495
59Microcytic anemia (HP:0001935)2.54073398
60Gingival bleeding (HP:0000225)2.53968463
61Joint swelling (HP:0001386)2.51431822
62Tachypnea (HP:0002789)2.48870553
63Eczematoid dermatitis (HP:0000976)2.47547102
64Reticulocytopenia (HP:0001896)2.47095961
65Exocrine pancreatic insufficiency (HP:0001738)2.46795859
66Abnormality of the common coagulation pathway (HP:0010990)2.45700159
67Alopecia of scalp (HP:0002293)2.45677300
68Hypotension (HP:0002615)2.45668215
69Pustule (HP:0200039)2.45177749
70Verrucae (HP:0200043)2.43343022
71Papilloma (HP:0012740)2.43343022
72Chronic diarrhea (HP:0002028)2.43032105
73Autoimmune thrombocytopenia (HP:0001973)2.41437956
74Chronic otitis media (HP:0000389)2.40663247
75Hyperkalemia (HP:0002153)2.40126389
76Azoospermia (HP:0000027)2.40028729
77Ileus (HP:0002595)2.39768015
78Hyperuricemia (HP:0002149)2.38628076
79Increased purine levels (HP:0004368)2.38628076
80B lymphocytopenia (HP:0010976)2.37503892
81Abnormality of B cell number (HP:0010975)2.37503892
82Vascular calcification (HP:0004934)2.36956594
83Abnormality of T cells (HP:0002843)2.36611028
84Ventricular fibrillation (HP:0001663)2.35791485
85Vacuolated lymphocytes (HP:0001922)2.34131205
86Microretrognathia (HP:0000308)2.33650308
87Paralysis (HP:0003470)2.33490283
88Abnormal gallbladder morphology (HP:0012437)2.33428171
89Polycythemia (HP:0001901)2.33278712
90Abnormality of T cell physiology (HP:0011840)2.31910767
91Cerebral palsy (HP:0100021)2.31566394
92Recurrent bronchitis (HP:0002837)2.31457850
93Rectal prolapse (HP:0002035)2.28779289
94T lymphocytopenia (HP:0005403)2.28417627
95Hypolipoproteinemia (HP:0010981)2.23266448
96Nausea (HP:0002018)2.22697495
97Thrombocytosis (HP:0001894)2.22559906
98Periodontitis (HP:0000704)2.22226523
99Agammaglobulinemia (HP:0004432)2.21662831
100Focal segmental glomerulosclerosis (HP:0000097)2.21380694
101Cardiovascular calcification (HP:0011915)2.21203137
102Hypoalphalipoproteinemia (HP:0003233)2.20793208
103Hypochromic microcytic anemia (HP:0004840)2.19829978
104Onycholysis (HP:0001806)2.17302723
105Abnormal platelet function (HP:0011869)2.16393424
106Impaired platelet aggregation (HP:0003540)2.16393424
107Reduced antithrombin III activity (HP:0001976)2.16290962
108Abnormality of T cell number (HP:0011839)2.14509585
109Arterial tortuosity (HP:0005116)2.12663910
110Oral leukoplakia (HP:0002745)2.11283239
111Goiter (HP:0000853)2.10948002
112Hydroxyprolinuria (HP:0003080)2.10194466
113Abnormality of proline metabolism (HP:0010907)2.10194466
114Abnormal tarsal ossification (HP:0008369)2.07912925
115Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.06803159
116Decreased activity of mitochondrial respiratory chain (HP:0008972)2.06803159
117Nonimmune hydrops fetalis (HP:0001790)2.05527911
118Insomnia (HP:0100785)2.05223476
119Megaloblastic anemia (HP:0001889)2.05000005
120Lymphoma (HP:0002665)2.04712227
121Respiratory distress (HP:0002098)2.03945552
122IgG deficiency (HP:0004315)2.02424584
123Abnormality of carpal bone ossification (HP:0006257)2.02019736
124Recurrent abscess formation (HP:0002722)2.00949059
125Hepatocellular carcinoma (HP:0001402)2.00231670
126Abnormality of the heme biosynthetic pathway (HP:0010472)10.8942144
127Beaking of vertebral bodies (HP:0004568)1.99871160
128Hyponatremia (HP:0002902)1.99603415
129Short middle phalanx of the 5th finger (HP:0004220)1.97693806
130Cellulitis (HP:0100658)1.96923713
131Hemorrhage of the eye (HP:0011885)1.96908327
132Tubulointerstitial abnormality (HP:0001969)1.95599737
133Basal cell carcinoma (HP:0002671)1.94515456
134Urinary glycosaminoglycan excretion (HP:0003541)1.94257890
135Mucopolysacchariduria (HP:0008155)1.94257890
136Urticaria (HP:0001025)1.93995769
137Hypoplasia of the thymus (HP:0000778)1.93211222
138Vascular tortuosity (HP:0004948)1.93171153
139Autoimmune hemolytic anemia (HP:0001890)1.92897598
140Cervical subluxation (HP:0003308)1.92297546
141Hypochromic anemia (HP:0001931)1.91456090
142Increased CSF protein (HP:0002922)1.90203194
143Combined immunodeficiency (HP:0005387)1.89383279
144Hypobetalipoproteinemia (HP:0003563)1.87639007
145Atrophic scars (HP:0001075)1.86072897
146Myelodysplasia (HP:0002863)1.84656999
147Panhypogammaglobulinemia (HP:0003139)1.84334858
148Abnormality of macrophages (HP:0004311)1.84196280
149Gastrointestinal inflammation (HP:0004386)1.83311129
150Abnormality of purine metabolism (HP:0004352)1.82705297
151Premature loss of primary teeth (HP:0006323)1.80342680
152Growth hormone excess (HP:0000845)1.80170290
153Meningitis (HP:0001287)1.79230006
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.79160185
155Abnormality of polysaccharide metabolism (HP:0011012)1.79160185
156Abnormality of glycosaminoglycan metabolism (HP:0004371)1.79160185
157Inflammation of the large intestine (HP:0002037)1.77644714
158Abnormality of small intestinal villus morphology (HP:0011472)1.76422003
159Villous atrophy (HP:0011473)1.76422003
160Recurrent fungal infections (HP:0002841)1.76226432
161Neutropenia (HP:0001875)1.74199446
162Cerebral aneurysm (HP:0004944)1.73996592
163Hepatocellular necrosis (HP:0001404)1.73648590
164Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.73003289
165Hypoplasia of the capital femoral epiphysis (HP:0003090)1.71379340
166Palpitations (HP:0001962)1.71336003
167Abnormality of the gallbladder (HP:0005264)1.71284356
168Recurrent sinusitis (HP:0011108)1.70189145
169Hepatic necrosis (HP:0002605)1.69569766
170Alveolar cell carcinoma (HP:0006519)1.69281266
171Breast hypoplasia (HP:0003187)1.67316866
172Abnormality of sodium homeostasis (HP:0010931)1.66464586
173Alkalosis (HP:0001948)1.66274639
174Severe combined immunodeficiency (HP:0004430)1.65487469
175Syncope (HP:0001279)1.64923842
176Biliary tract neoplasm (HP:0100574)1.64915586
177Lymphopenia (HP:0001888)1.64349546
178Recurrent bacterial skin infections (HP:0005406)1.64274984
179Pulmonary hypertension (HP:0002092)1.64197578
180Abnormal delayed hypersensitivity skin test (HP:0002963)1.63912757
181Abnormal platelet volume (HP:0011876)1.61572773
182Gastrointestinal stroma tumor (HP:0100723)1.60356619
183Cholecystitis (HP:0001082)1.59946252
184Abnormal gallbladder physiology (HP:0012438)1.59946252
185Encephalitis (HP:0002383)1.59006533
186Skin rash (HP:0000988)1.58734841
187Pancytopenia (HP:0001876)1.57589132
188Abnormality of cells of the lymphoid lineage (HP:0012140)1.56720177
189Poikiloderma (HP:0001029)1.55786512
19011 pairs of ribs (HP:0000878)1.54911208
191Spastic diplegia (HP:0001264)1.54681313
192Increased serum lactate (HP:0002151)1.54204631
193Exertional dyspnea (HP:0002875)1.54125942
194Increased intramyocellular lipid droplets (HP:0012240)1.53400210
195Type I transferrin isoform profile (HP:0003642)1.53079997

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LMTK25.02334088
2EPHA24.50366607
3NME23.59224102
4MET3.38931496
5EIF2AK13.35295583
6MAP4K13.24518683
7CDC73.15464138
8MST42.98518087
9STK102.88928135
10PDK22.87403951
11STK392.51675411
12VRK12.41648379
13RIPK12.37745785
14ERBB42.27973143
15OXSR12.11108149
16MAP3K102.06467138
17PIK3CA2.03138879
18TLK11.99300257
19LRRK21.98782846
20WEE11.88689636
21TYK21.81117411
22ZAP701.73662886
23EEF2K1.72320076
24GRK61.70259172
25TXK1.66496067
26STK41.65984804
27FER1.58039489
28NEK21.51042143
29EPHA31.50124364
30ACVR1B1.49921180
31KDR1.48577851
32SCYL21.46008176
33JAK31.44843715
34BTK1.44744614
35MAP3K81.36271556
36FGFR41.35242953
37PBK1.32989620
38FLT31.32080948
39LATS11.31267130
40NLK1.29078479
41TAOK31.27560653
42TBK11.27263388
43RPS6KA41.27025527
44AURKB1.25492691
45PIM21.24879372
46EPHB21.24806402
47STK241.24199923
48BUB11.24060881
49TGFBR21.23575315
50PKN21.21270406
51GRK11.20373785
52PRKG21.19446293
53PDGFRB1.17449103
54NEK11.15829560
55SYK1.15650003
56DYRK31.15005722
57EPHB11.10775464
58MAP2K31.10547605
59FGFR31.10451206
60PIM11.10197607
61STK161.10080516
62CDK41.09680222
63STK38L1.07648377
64RPS6KB21.07414204
65KIT1.05667412
66BRSK21.04785483
67MAP3K111.03416012
68CDK70.99619315
69MAP3K20.99596442
70ITK0.97375580
71TEC0.97230461
72IKBKE0.96930936
73CCNB10.96160634
74ATR0.95897336
75BLK0.95791587
76IRAK40.94775904
77EIF2AK30.93906304
78LYN0.91911622
79JAK20.91153133
80CDC42BPA0.88713599
81CDK190.88639473
82CLK10.88098206
83MAP3K120.85387199
84NEK90.83896806
85MAPKAPK50.83663531
86SRPK10.82549601
87TESK20.81856219
88MST1R0.79669308
89BRSK10.79531974
90BCR0.78068942
91BCKDK0.77216072
92ERN10.74906098
93PTK60.74031194
94MAP3K60.73461392
95SIK30.73012127
96MAPK110.72906630
97PLK10.72071997
98TGFBR10.71228345
99CSF1R0.70620908
100TRIB30.70104748
101YES10.69474705
102LCK0.69260939
103PAK40.66558858
104PIK3CG0.65723322
105CSK0.65528310
106IKBKB0.64715000
107RPS6KA50.64676014
108PDPK10.62535088
109RIPK40.62123229
110PDGFRA0.61528636
111MELK0.61375775
112CDK60.60118931
113ERBB20.60062783
114MATK0.58218372
115MAPKAPK30.56025627
116CDK80.55186341
117IGF1R0.53696709
118AKT30.51225600
119STK30.51222292
120ZAK0.49781248
121MAP2K60.49166137
122MAP3K70.48720171
123DAPK10.47665020
124AURKA0.47461612
125TRIM280.46948729
126IRAK30.46511269
127DDR20.46017258
128ATM0.45548373
129PTK20.45320136
130MAP3K140.45298998
131PRKCE0.43449529
132MAPKAPK20.42653582
133JAK10.42647250
134RPS6KA60.42643298
135NUAK10.42076640
136TAOK10.41911801
137NME10.41685084
138CHEK10.41043568
139ERBB30.40793916
140DMPK0.40598923
141EGFR0.40261705
142PRKCQ0.39549083
143MYLK0.39157156
144NEK60.38136193
145MAP3K30.37347351
146FRK0.37020308
147TESK10.36780666
148CSNK2A10.36407848
149TNK20.36297489
150TRPM70.36210684
151ROCK10.34509381
152PRKAA20.34201345
153TIE10.33249683
154CSNK2A20.33222126
155CDK90.32911142
156PRKCD0.31791614
157PDK10.30377209
158BMPR1B0.29627966
159IRAK10.29453949
160SRC0.27833460
161STK380.27783686
162CASK0.27581630
163ABL10.27088192
164CHUK0.26666216
165MAP2K20.25915077
166DAPK20.25463401
167MAP3K130.25266137
168BMX0.23545697
169RET0.21412327
170MAP3K10.21047712
171BMPR20.20525747

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.17560571
2Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008604.17107288
3Mismatch repair_Homo sapiens_hsa034303.35347546
4Ribosome_Homo sapiens_hsa030103.07663694
5Base excision repair_Homo sapiens_hsa034102.37262480
6Mineral absorption_Homo sapiens_hsa049782.28359415
7Systemic lupus erythematosus_Homo sapiens_hsa053222.14806281
8Asthma_Homo sapiens_hsa053102.13164039
9Collecting duct acid secretion_Homo sapiens_hsa049662.11754170
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.11299907
11Primary immunodeficiency_Homo sapiens_hsa053402.08734154
12Nucleotide excision repair_Homo sapiens_hsa034202.01606177
13Caffeine metabolism_Homo sapiens_hsa002322.00709674
14Pyrimidine metabolism_Homo sapiens_hsa002401.99886423
15Complement and coagulation cascades_Homo sapiens_hsa046101.96762029
16Proteasome_Homo sapiens_hsa030501.93356335
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.85395133
18Spliceosome_Homo sapiens_hsa030401.82512951
19Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80452578
20One carbon pool by folate_Homo sapiens_hsa006701.76719453
21Cell cycle_Homo sapiens_hsa041101.76023450
22Protein digestion and absorption_Homo sapiens_hsa049741.74380605
23Homologous recombination_Homo sapiens_hsa034401.72909182
24Sulfur relay system_Homo sapiens_hsa041221.72397328
25Non-homologous end-joining_Homo sapiens_hsa034501.71529569
26Histidine metabolism_Homo sapiens_hsa003401.66699891
27Steroid hormone biosynthesis_Homo sapiens_hsa001401.65379149
28Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.62520406
29Folate biosynthesis_Homo sapiens_hsa007901.53564459
30Hematopoietic cell lineage_Homo sapiens_hsa046401.48193382
31Glutathione metabolism_Homo sapiens_hsa004801.48012839
32Pancreatic secretion_Homo sapiens_hsa049721.47753529
33Cyanoamino acid metabolism_Homo sapiens_hsa004601.46577103
34Retinol metabolism_Homo sapiens_hsa008301.45283197
35Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43410549
36Other glycan degradation_Homo sapiens_hsa005111.41421127
37Autoimmune thyroid disease_Homo sapiens_hsa053201.39869426
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36923084
39Nitrogen metabolism_Homo sapiens_hsa009101.35574731
40Leukocyte transendothelial migration_Homo sapiens_hsa046701.34166979
41Starch and sucrose metabolism_Homo sapiens_hsa005001.33484258
42Antigen processing and presentation_Homo sapiens_hsa046121.33325890
43Sphingolipid metabolism_Homo sapiens_hsa006001.31460622
44Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.30542685
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.29786729
46PPAR signaling pathway_Homo sapiens_hsa033201.27796977
47p53 signaling pathway_Homo sapiens_hsa041151.27745920
48Pentose phosphate pathway_Homo sapiens_hsa000301.26566229
49Graft-versus-host disease_Homo sapiens_hsa053321.24353020
50Fat digestion and absorption_Homo sapiens_hsa049751.23249658
51Tight junction_Homo sapiens_hsa045301.18991000
52Arachidonic acid metabolism_Homo sapiens_hsa005901.16957603
53Glycerolipid metabolism_Homo sapiens_hsa005611.15942334
54Herpes simplex infection_Homo sapiens_hsa051681.15695006
55African trypanosomiasis_Homo sapiens_hsa051431.14578523
56Maturity onset diabetes of the young_Homo sapiens_hsa049501.14489163
57Chemical carcinogenesis_Homo sapiens_hsa052041.14479796
58Selenocompound metabolism_Homo sapiens_hsa004501.11455795
59Sulfur metabolism_Homo sapiens_hsa009201.11360532
60RNA transport_Homo sapiens_hsa030131.11292546
61Drug metabolism - other enzymes_Homo sapiens_hsa009831.11275647
62Bile secretion_Homo sapiens_hsa049761.11270469
63Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.11178414
64Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.11074307
65Measles_Homo sapiens_hsa051621.09303890
66Renin-angiotensin system_Homo sapiens_hsa046141.07159727
67Glycosaminoglycan degradation_Homo sapiens_hsa005311.06851857
68Fanconi anemia pathway_Homo sapiens_hsa034601.05946591
69RNA polymerase_Homo sapiens_hsa030201.05124200
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05101318
71Type I diabetes mellitus_Homo sapiens_hsa049401.04452078
72Hepatitis C_Homo sapiens_hsa051601.00510217
73Arginine biosynthesis_Homo sapiens_hsa002200.99975902
74Ether lipid metabolism_Homo sapiens_hsa005650.97880031
75Leishmaniasis_Homo sapiens_hsa051400.96527364
76Viral carcinogenesis_Homo sapiens_hsa052030.93422677
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.92406411
78Intestinal immune network for IgA production_Homo sapiens_hsa046720.92017710
79Cysteine and methionine metabolism_Homo sapiens_hsa002700.90722808
80Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.89343766
81B cell receptor signaling pathway_Homo sapiens_hsa046620.89296883
82RNA degradation_Homo sapiens_hsa030180.88886912
83ECM-receptor interaction_Homo sapiens_hsa045120.88769286
84Galactose metabolism_Homo sapiens_hsa000520.88393094
85ABC transporters_Homo sapiens_hsa020100.87260991
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.86073420
87Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.85047551
88Pertussis_Homo sapiens_hsa051330.83913976
89Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.82826294
90* Lysosome_Homo sapiens_hsa041420.81734588
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81518176
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.77466965
93Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76730983
94Thyroid hormone synthesis_Homo sapiens_hsa049180.74613289
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.74420652
96Parkinsons disease_Homo sapiens_hsa050120.74225755
97Tryptophan metabolism_Homo sapiens_hsa003800.73863759
98Fatty acid degradation_Homo sapiens_hsa000710.73686006
99Purine metabolism_Homo sapiens_hsa002300.73153004
100Hepatitis B_Homo sapiens_hsa051610.73135942
101Linoleic acid metabolism_Homo sapiens_hsa005910.72282199
102Apoptosis_Homo sapiens_hsa042100.71707374
103Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.71639918
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71638995
105Vibrio cholerae infection_Homo sapiens_hsa051100.71391296
106Vitamin digestion and absorption_Homo sapiens_hsa049770.71285879
107Viral myocarditis_Homo sapiens_hsa054160.71225168
108NF-kappa B signaling pathway_Homo sapiens_hsa040640.70954765
109Malaria_Homo sapiens_hsa051440.70116338
110Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69111376
111Legionellosis_Homo sapiens_hsa051340.67082553
112Adherens junction_Homo sapiens_hsa045200.65364610
113Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64924801
114Oxidative phosphorylation_Homo sapiens_hsa001900.61196672
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.59849891
116Pyruvate metabolism_Homo sapiens_hsa006200.59837000
117RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.58066172
118AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.57418278
119Phagosome_Homo sapiens_hsa041450.57213780
120Arginine and proline metabolism_Homo sapiens_hsa003300.56894165
121Propanoate metabolism_Homo sapiens_hsa006400.56742141
122Alcoholism_Homo sapiens_hsa050340.56083191
123N-Glycan biosynthesis_Homo sapiens_hsa005100.55538521
124Rheumatoid arthritis_Homo sapiens_hsa053230.53992502
125Protein export_Homo sapiens_hsa030600.52588804
126Epstein-Barr virus infection_Homo sapiens_hsa051690.52088515
127Fructose and mannose metabolism_Homo sapiens_hsa000510.52000574
128Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51741065
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.51341917
130Staphylococcus aureus infection_Homo sapiens_hsa051500.51336557
131Small cell lung cancer_Homo sapiens_hsa052220.51251337
132Carbon metabolism_Homo sapiens_hsa012000.50379043
133Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48241474
134Fatty acid elongation_Homo sapiens_hsa000620.47830112
135Allograft rejection_Homo sapiens_hsa053300.47773285
136Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46983722
137Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.46337031
138T cell receptor signaling pathway_Homo sapiens_hsa046600.45950269
139Influenza A_Homo sapiens_hsa051640.45599185
140Acute myeloid leukemia_Homo sapiens_hsa052210.44752376
141Glycerophospholipid metabolism_Homo sapiens_hsa005640.44375753
142Osteoclast differentiation_Homo sapiens_hsa043800.44042907
143Amoebiasis_Homo sapiens_hsa051460.43948513
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42864669
145Gastric acid secretion_Homo sapiens_hsa049710.41762779
146Toxoplasmosis_Homo sapiens_hsa051450.40309089
147Basal transcription factors_Homo sapiens_hsa030220.39385713
148Shigellosis_Homo sapiens_hsa051310.39230782
149Thyroid cancer_Homo sapiens_hsa052160.38192896
150Transcriptional misregulation in cancer_Homo sapiens_hsa052020.37805194
151Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.37642223
152Biosynthesis of amino acids_Homo sapiens_hsa012300.37478160
153Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.37345649
154Peroxisome_Homo sapiens_hsa041460.36612816
155Metabolic pathways_Homo sapiens_hsa011000.36575116
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35507211
157Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.35119416
158Chronic myeloid leukemia_Homo sapiens_hsa052200.32626981
159Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.32307771
160Jak-STAT signaling pathway_Homo sapiens_hsa046300.32262719
161beta-Alanine metabolism_Homo sapiens_hsa004100.31695433
162Fatty acid metabolism_Homo sapiens_hsa012120.31670396
163Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30873200
164Tuberculosis_Homo sapiens_hsa051520.30296132
165Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29630714
166Focal adhesion_Homo sapiens_hsa045100.29253762

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