CTSF

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cathepsins are papain family cysteine proteinases that represent a major component of the lysosomal proteolytic system. Cathepsins generally contain a signal sequence, followed by a propeptide and then a catalytically active mature region. The very long (251 amino acid residues) proregion of the cathepsin F precursor contains a C-terminal domain similar to the pro-segment of cathepsin L-like enzymes, a 50-residue flexible linker peptide, and an N-terminal domain predicted to adopt a cystatin-like fold. The cathepsin F proregion is unique within the papain family cysteine proteases in that it contains this additional N-terminal segment predicted to share structural similarities with cysteine protease inhibitors of the cystatin superfamily. This cystatin-like domain contains some of the elements known to be important for inhibitory activity. CTSF encodes a predicted protein of 484 amino acids which contains a 19 residue signal peptide. Cathepsin F contains five potential N-glycosylation sites, and it may be targeted to the endosomal/lysosomal compartment via the mannose 6-phosphate receptor pathway. The cathepsin F gene is ubiquitously expressed, and it maps to chromosome 11q13, close to the gene encoding cathepsin W. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle docking involved in exocytosis (GO:0016081)5.48291361
2response to pheromone (GO:0019236)4.04174871
3cellular potassium ion homeostasis (GO:0030007)3.89847423
4cerebellar granule cell differentiation (GO:0021707)3.64168657
5sodium ion export (GO:0071436)3.47408596
6neuronal ion channel clustering (GO:0045161)3.31786498
7cell communication by electrical coupling (GO:0010644)3.30835360
8potassium ion homeostasis (GO:0055075)3.30204150
9positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.29990352
10cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.24495931
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.20363717
12negative regulation of cytosolic calcium ion concentration (GO:0051481)3.13311184
13positive regulation of synapse maturation (GO:0090129)3.00550955
14cytoskeletal anchoring at plasma membrane (GO:0007016)2.98135707
15amino acid import (GO:0043090)2.95553539
16regulation of short-term neuronal synaptic plasticity (GO:0048172)2.92623523
17regulation of ARF protein signal transduction (GO:0032012)2.91357597
18synaptic vesicle maturation (GO:0016188)2.88855558
19synaptic vesicle exocytosis (GO:0016079)2.88200463
20alanine transport (GO:0032328)2.86917623
21neuromuscular process controlling balance (GO:0050885)2.86613629
22potassium ion import (GO:0010107)2.85658962
23retinal rod cell development (GO:0046548)2.84218479
24regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.79064404
25regulation of female receptivity (GO:0045924)2.78501730
26cerebellar Purkinje cell layer development (GO:0021680)2.75773571
27creatine metabolic process (GO:0006600)2.73466164
28cellular sodium ion homeostasis (GO:0006883)2.71021554
29regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67097420
30L-phenylalanine catabolic process (GO:0006559)2.66677231
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.66677231
32regulation of long-term neuronal synaptic plasticity (GO:0048169)2.59589034
33alpha-linolenic acid metabolic process (GO:0036109)2.58748275
34regulation of synaptic vesicle exocytosis (GO:2000300)2.57498271
35cellular ketone body metabolic process (GO:0046950)2.52513583
36nitric oxide mediated signal transduction (GO:0007263)2.50495297
37regulation of glutamate receptor signaling pathway (GO:1900449)2.49693426
38detection of light stimulus involved in visual perception (GO:0050908)2.49277072
39detection of light stimulus involved in sensory perception (GO:0050962)2.49277072
40L-phenylalanine metabolic process (GO:0006558)2.48894659
41erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.48894659
42regulation of synaptic plasticity (GO:0048167)2.48609339
43detection of calcium ion (GO:0005513)2.46932138
44macroautophagy (GO:0016236)2.46839974
45response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.44153413
46negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.44000284
47G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.43777541
48mating behavior (GO:0007617)2.43007056
49protein retention in ER lumen (GO:0006621)2.41938430
50Golgi transport vesicle coating (GO:0048200)2.41821580
51COPI coating of Golgi vesicle (GO:0048205)2.41821580
52virion attachment to host cell (GO:0019062)2.41134045
53adhesion of symbiont to host cell (GO:0044650)2.41134045
54exploration behavior (GO:0035640)2.41057774
55barbed-end actin filament capping (GO:0051016)2.40279553
56regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.39610253
57vocalization behavior (GO:0071625)2.39510895
58layer formation in cerebral cortex (GO:0021819)2.39423890
59postsynaptic membrane organization (GO:0001941)2.39036354
60regulation of synapse maturation (GO:0090128)2.39011112
61cell volume homeostasis (GO:0006884)2.38950823
62female mating behavior (GO:0060180)2.38849697
63regulation of neurotransmitter secretion (GO:0046928)2.38737801
64positive regulation of dendritic spine development (GO:0060999)2.38695119
65cardiac muscle contraction (GO:0060048)2.38477094
66peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)2.36939025
67cGMP-mediated signaling (GO:0019934)2.36507636
68L-serine transport (GO:0015825)2.35931872
69neurotransmitter-gated ion channel clustering (GO:0072578)2.35178153
70positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.34392467
71regulation of synaptic vesicle transport (GO:1902803)2.33634952
72regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.33282185
73astrocyte development (GO:0014002)2.32989263
74negative regulation of synaptic transmission, GABAergic (GO:0032229)2.31269267
75ovulation cycle (GO:0042698)2.30711575
76glutamate secretion (GO:0014047)2.29478503
77regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.29393865
78locomotory exploration behavior (GO:0035641)2.28967397
79regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.28915033
80positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.28756750
81C21-steroid hormone biosynthetic process (GO:0006700)2.28155376
82regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.27451601
83response to leptin (GO:0044321)2.27322845
84regulation of neurotransmitter levels (GO:0001505)2.27319262
85glucocorticoid biosynthetic process (GO:0006704)2.27046638
86regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.26393140
87NADH metabolic process (GO:0006734)2.26389130
88neuromuscular process controlling posture (GO:0050884)2.26261630
89sarcoplasmic reticulum calcium ion transport (GO:0070296)2.25803930
90peripheral nervous system axon ensheathment (GO:0032292)2.25416660
91myelination in peripheral nervous system (GO:0022011)2.25416660
92astrocyte differentiation (GO:0048708)2.25401456
93synaptic vesicle endocytosis (GO:0048488)2.25216765
94neuron projection regeneration (GO:0031102)2.24601412
95positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.24557123
96positive regulation of neurotransmitter secretion (GO:0001956)2.24292610
97regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.24159808
98glycine transport (GO:0015816)2.24097085
99regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.23967227
100ionotropic glutamate receptor signaling pathway (GO:0035235)2.23294092
101response to epinephrine (GO:0071871)2.22369867
102regulation of voltage-gated calcium channel activity (GO:1901385)2.21928080
103acidic amino acid transport (GO:0015800)2.20371519
104membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.20313219
105regulation of cell communication by electrical coupling (GO:0010649)2.19044494
106regulation of synapse structural plasticity (GO:0051823)2.18355459
107neurotransmitter secretion (GO:0007269)2.18185818
108eye photoreceptor cell differentiation (GO:0001754)2.18165371
109photoreceptor cell differentiation (GO:0046530)2.18165371
110keratan sulfate catabolic process (GO:0042340)2.17381344
111response to dietary excess (GO:0002021)2.15947038
112innervation (GO:0060384)2.15854431
113positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.15483783
114glucocorticoid metabolic process (GO:0008211)2.15179927
115cellular response to catecholamine stimulus (GO:0071870)2.14530775
116ketone body metabolic process (GO:1902224)2.14046020
117sodium ion homeostasis (GO:0055078)2.13711588
118chondroitin sulfate catabolic process (GO:0030207)2.13358171
119estrogen biosynthetic process (GO:0006703)2.12305354
120gamma-aminobutyric acid transport (GO:0015812)2.11386333
121positive regulation of potassium ion transport (GO:0043268)2.11105636
122positive regulation of potassium ion transmembrane transport (GO:1901381)2.09425022
123toxin metabolic process (GO:0009404)2.08683817
124positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.08560844
125neuronal action potential propagation (GO:0019227)2.07896989
126G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.03814900
127very long-chain fatty acid metabolic process (GO:0000038)2.03737261
128response to methylmercury (GO:0051597)2.01456962
129membrane repolarization (GO:0086009)2.01388746
130regulation of autophagic vacuole assembly (GO:2000785)2.00868652
131adhesion of symbiont to host (GO:0044406)2.00659579
132positive regulation of triglyceride biosynthetic process (GO:0010867)2.00473042
133cell communication involved in cardiac conduction (GO:0086065)2.00259317
134protein localization to synapse (GO:0035418)1.99986380
135regulation of membrane repolarization (GO:0060306)1.99132224
136C4-dicarboxylate transport (GO:0015740)1.99015114
137positive regulation of glycolytic process (GO:0045821)1.97275036
138axon ensheathment in central nervous system (GO:0032291)1.96716670
139central nervous system myelination (GO:0022010)1.96716670
140iron coordination entity transport (GO:1901678)1.96666660
141short-chain fatty acid metabolic process (GO:0046459)1.95913325
142cellular modified amino acid catabolic process (GO:0042219)1.94839081
143regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO1.94520554
144L-amino acid import (GO:0043092)1.94371334
145neurotransmitter transport (GO:0006836)1.93842177
146regulation of cholesterol homeostasis (GO:2000188)1.93754675
147regulation of amyloid precursor protein catabolic process (GO:1902991)1.92806051
148serine transport (GO:0032329)1.92493897
149lysine catabolic process (GO:0006554)1.91807762
150lysine metabolic process (GO:0006553)1.91807762
151neuron remodeling (GO:0016322)1.91522698
152reverse cholesterol transport (GO:0043691)1.90291012
153fatty acid beta-oxidation (GO:0006635)1.90184461
154regulation of vesicle fusion (GO:0031338)1.90031033
155activation of protein kinase A activity (GO:0034199)1.89808066
156regulation of beta-amyloid formation (GO:1902003)1.89729055
157regulation of neuronal synaptic plasticity (GO:0048168)1.89560337
158regulation of type B pancreatic cell apoptotic process (GO:2000674)1.89134132
159tricarboxylic acid metabolic process (GO:0072350)1.88992760
160membrane hyperpolarization (GO:0060081)1.88623842
161nucleoside diphosphate catabolic process (GO:0009134)1.87458916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.52668454
2GBX2_23144817_ChIP-Seq_PC3_Human2.52061821
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.42141230
4SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.25781115
5SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.24491996
6EZH2_22144423_ChIP-Seq_EOC_Human2.23101841
7MTF2_20144788_ChIP-Seq_MESCs_Mouse2.20531280
8JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19386728
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.17037184
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.16488302
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.16488302
12SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09544610
13DROSHA_22980978_ChIP-Seq_HELA_Human2.04630590
14EZH2_27294783_Chip-Seq_ESCs_Mouse2.04022768
15EED_16625203_ChIP-ChIP_MESCs_Mouse2.03081504
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.97346272
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.96691080
18SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96286969
19EZH2_27304074_Chip-Seq_ESCs_Mouse1.84345717
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.78089004
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.77236680
22ZFP281_18757296_ChIP-ChIP_E14_Mouse1.74065917
23REST_21632747_ChIP-Seq_MESCs_Mouse1.72950608
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.71535896
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.69336683
26IKZF1_21737484_ChIP-ChIP_HCT116_Human1.61295355
27REST_18959480_ChIP-ChIP_MESCs_Mouse1.54526093
28TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.53582236
29LXR_22158963_ChIP-Seq_LIVER_Mouse1.52382771
30FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.48514987
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.48299116
32RARB_27405468_Chip-Seq_BRAIN_Mouse1.43244413
33AR_21572438_ChIP-Seq_LNCaP_Human1.41641738
34PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.40433455
35TBX20_22328084_ChIP-Seq_HEART_Mouse1.36510786
36TBX20_22080862_ChIP-Seq_HEART_Mouse1.36510786
37ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.35022005
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.33873732
39PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30925867
40TRIM28_21343339_ChIP-Seq_HEK293_Human1.28709784
41TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.28512692
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.28036437
43SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.26496212
44TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.26401866
45RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.25756680
46* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25718222
47CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25535341
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.24922448
49KDM2B_26808549_Chip-Seq_DND41_Human1.24803657
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.24008899
51DNAJC2_21179169_ChIP-ChIP_NT2_Human1.23629958
52SMC4_20622854_ChIP-Seq_HELA_Human1.23059157
53UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22706242
54RACK7_27058665_Chip-Seq_MCF-7_Human1.22412609
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.21896490
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.21892430
57NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.20461918
58THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.19168553
59PIAS1_25552417_ChIP-Seq_VCAP_Human1.18286656
60EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.17692682
61CLOCK_20551151_ChIP-Seq_293T_Human1.17315692
62* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.16024705
63PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.15826845
64PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.15449719
65RING1B_27294783_Chip-Seq_ESCs_Mouse1.14340109
66TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.13937452
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.13210612
68EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.12698062
69CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11809465
70ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.11388021
71BCAT_22108803_ChIP-Seq_LS180_Human1.09005529
72* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08836124
73P68_20966046_ChIP-Seq_HELA_Human1.08296986
74* SA1_27219007_Chip-Seq_ERYTHROID_Human1.07358810
75ESR2_21235772_ChIP-Seq_MCF-7_Human1.06358329
76NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04740146
77EP300_21415370_ChIP-Seq_HL-1_Mouse1.04239002
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.04234722
79TP53_23651856_ChIP-Seq_MEFs_Mouse1.04175146
80ZFP281_27345836_Chip-Seq_ESCs_Mouse1.03180167
81SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.02979940
82SMC1_22415368_ChIP-Seq_MEFs_Mouse1.01357301
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.00949934
84* TET1_21451524_ChIP-Seq_MESCs_Mouse1.00923581
85CTCF_27219007_Chip-Seq_Bcells_Human1.00849709
86PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.00737990
87CREB1_26743006_Chip-Seq_LNCaP_Human1.00525051
88KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.99492647
89RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99138219
90CTBP1_25329375_ChIP-Seq_LNCAP_Human0.98909979
91CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.98642350
92ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98604335
93CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98601681
94* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97959993
95SOX2_21211035_ChIP-Seq_LN229_Gbm0.97328068
96SMAD4_21799915_ChIP-Seq_A2780_Human0.95599984
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95498616
98KDM2B_26808549_Chip-Seq_K562_Human0.94970321
99* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94466639
100RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.94384217
101NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94383861
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94238891
103SMC3_22415368_ChIP-Seq_MEFs_Mouse0.93454461
104AR_25329375_ChIP-Seq_VCAP_Human0.91931602
105ZNF217_24962896_ChIP-Seq_MCF-7_Human0.91774144
106AR_19668381_ChIP-Seq_PC3_Human0.91477476
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.90852584
108P300_27058665_Chip-Seq_ZR-75-30cells_Human0.90843358
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90161402
110LXR_22292898_ChIP-Seq_THP-1_Human0.90143334
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.90078538
112CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89332449
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88378200
114SMAD4_21741376_ChIP-Seq_HESCs_Human0.88218005
115GATA2_21666600_ChIP-Seq_HMVEC_Human0.88217316
116ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.87714408
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87155763
118WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.85854445
119TP53_20018659_ChIP-ChIP_R1E_Mouse0.85821140
120ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.84796134
121NRF2_20460467_ChIP-Seq_MEFs_Mouse0.84747159
122NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.84747159
123TET1_21490601_ChIP-Seq_MESCs_Mouse0.84562463
124RING1B_27294783_Chip-Seq_NPCs_Mouse0.84416693
125GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84032055
126TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83867232
127SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.82585236
128CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.81776056
129ZNF274_21170338_ChIP-Seq_K562_Hela0.77487742
130NR3C1_21868756_ChIP-Seq_MCF10A_Human0.77365779
131STAT3_23295773_ChIP-Seq_U87_Human0.77120280
132NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.77105587
133SMAD3_21741376_ChIP-Seq_EPCs_Human0.76673851
134MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.76179575
135* P300_19829295_ChIP-Seq_ESCs_Human0.75643639
136RARG_19884340_ChIP-ChIP_MEFs_Mouse0.75319602
137CBX2_27304074_Chip-Seq_ESCs_Mouse0.74960473
138ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.74606598
139AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.74419524
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.74330601

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009780_abnormal_chondrocyte_physiolo2.84260877
2MP0005551_abnormal_eye_electrophysiolog2.81787649
3MP0004043_abnormal_pH_regulation2.51894515
4MP0002909_abnormal_adrenal_gland2.51841548
5MP0000013_abnormal_adipose_tissue2.36808673
6MP0004859_abnormal_synaptic_plasticity2.17455046
7MP0006072_abnormal_retinal_apoptosis2.15121912
8MP0004885_abnormal_endolymph2.09641554
9MP0003283_abnormal_digestive_organ2.07530246
10MP0001502_abnormal_circadian_rhythm2.07410942
11MP0005503_abnormal_tendon_morphology2.00521009
12MP0002090_abnormal_vision2.00478224
13MP0003705_abnormal_hypodermis_morpholog1.98786767
14MP0003329_amyloid_beta_deposits1.98512834
15MP0010386_abnormal_urinary_bladder1.97101629
16MP0005670_abnormal_white_adipose1.92471879
17MP0003011_delayed_dark_adaptation1.90645766
18MP0003635_abnormal_synaptic_transmissio1.88651906
19MP0003183_abnormal_peptide_metabolism1.88315046
20MP0003195_calcinosis1.85465724
21MP0005253_abnormal_eye_physiology1.83681101
22MP0005646_abnormal_pituitary_gland1.83036061
23MP0003690_abnormal_glial_cell1.82349848
24MP0002139_abnormal_hepatobiliary_system1.81672465
25MP0004270_analgesia1.76678771
26MP0005275_abnormal_skin_tensile1.74692079
27MP0003279_aneurysm1.72262762
28MP0001958_emphysema1.70862087
29MP0005257_abnormal_intraocular_pressure1.67164831
30MP0002064_seizures1.63602447
31MP0000747_muscle_weakness1.62074334
32MP0005365_abnormal_bile_salt1.60375275
33MP0002272_abnormal_nervous_system1.53928983
34MP0000749_muscle_degeneration1.53569537
35MP0001486_abnormal_startle_reflex1.50033672
36MP0002638_abnormal_pupillary_reflex1.49442723
37MP0004510_myositis1.47935740
38MP0001984_abnormal_olfaction1.45917849
39MP0009840_abnormal_foam_cell1.45793265
40MP0002837_dystrophic_cardiac_calcinosis1.43060421
41MP0002229_neurodegeneration1.42054940
42MP0009046_muscle_twitch1.42011905
43MP0005058_abnormal_lysosome_morphology1.40728089
44MP0005360_urolithiasis1.40006332
45MP0003646_muscle_fatigue1.37358965
46MP0003880_abnormal_central_pattern1.35490511
47MP0003633_abnormal_nervous_system1.35045208
48MP0002063_abnormal_learning/memory/cond1.33621363
49MP0005167_abnormal_blood-brain_barrier1.31847827
50MP0004858_abnormal_nervous_system1.30573215
51* MP0003634_abnormal_glial_cell1.30171327
52MP0008438_abnormal_cutaneous_collagen1.28814602
53MP0005171_absent_coat_pigmentation1.28317750
54MP0009745_abnormal_behavioral_response1.27596902
55MP0005332_abnormal_amino_acid1.25735873
56MP0004145_abnormal_muscle_electrophysio1.25371210
57MP0002572_abnormal_emotion/affect_behav1.24795345
58MP0002822_catalepsy1.23958664
59MP0000759_abnormal_skeletal_muscle1.23029460
60MP0010329_abnormal_lipoprotein_level1.22224454
61MP0004130_abnormal_muscle_cell1.21993494
62MP0005645_abnormal_hypothalamus_physiol1.21913306
63MP0002734_abnormal_mechanical_nocicepti1.20987543
64MP0000751_myopathy1.20740095
65MP0000604_amyloidosis1.20574922
66MP0001905_abnormal_dopamine_level1.20090075
67MP0004087_abnormal_muscle_fiber1.19568776
68MP0005423_abnormal_somatic_nervous1.18118715
69MP0000003_abnormal_adipose_tissue1.17195013
70MP0000639_abnormal_adrenal_gland1.16242584
71MP0000230_abnormal_systemic_arterial1.14551945
72MP0004084_abnormal_cardiac_muscle1.14527172
73MP0005535_abnormal_body_temperature1.11881603
74MP0008875_abnormal_xenobiotic_pharmacok1.11625429
75MP0003879_abnormal_hair_cell1.11329884
76MP0005195_abnormal_posterior_eye1.10814517
77MP0002971_abnormal_brown_adipose1.08479045
78MP0006138_congestive_heart_failure1.08250609
79MP0003075_altered_response_to1.07110954
80MP0002295_abnormal_pulmonary_circulatio1.06995788
81* MP0002067_abnormal_sensory_capabilities1.06841777
82MP0002269_muscular_atrophy1.06528939
83MP0001440_abnormal_grooming_behavior1.05961533
84MP0005085_abnormal_gallbladder_physiolo1.05572731
85MP0003252_abnormal_bile_duct1.05570150
86MP0003191_abnormal_cellular_cholesterol1.05300536
87MP0010368_abnormal_lymphatic_system1.04416185
88MP0002078_abnormal_glucose_homeostasis1.03713918
89MP0008874_decreased_physiological_sensi1.03713048
90MP0001501_abnormal_sleep_pattern1.03606004
91MP0008569_lethality_at_weaning1.03011501
92MP0003172_abnormal_lysosome_physiology1.02695963
93MP0002118_abnormal_lipid_homeostasis1.02689351
94MP0004215_abnormal_myocardial_fiber1.02461627
95MP0009384_cardiac_valve_regurgitation1.02044712
96MP0001765_abnormal_ion_homeostasis1.01627999
97MP0005165_increased_susceptibility_to1.01349813
98MP0005330_cardiomyopathy1.00714238
99MP0000920_abnormal_myelination0.99531567
100MP0000681_abnormal_thyroid_gland0.98569690
101MP0004036_abnormal_muscle_relaxation0.98021016
102MP0002557_abnormal_social/conspecific_i0.97489534
103MP0005220_abnormal_exocrine_pancreas0.96613872
104MP0001944_abnormal_pancreas_morphology0.96062398
105MP0002735_abnormal_chemical_nociception0.94995019
106MP0000631_abnormal_neuroendocrine_gland0.94179776
107MP0004233_abnormal_muscle_weight0.94162789
108MP0004142_abnormal_muscle_tone0.94074890
109* MP0002066_abnormal_motor_capabilities/c0.93642734
110* MP0002882_abnormal_neuron_morphology0.93522965
111MP0005620_abnormal_muscle_contractility0.93153812
112MP0005375_adipose_tissue_phenotype0.93119094
113MP0004019_abnormal_vitamin_homeostasis0.91605353
114MP0008961_abnormal_basal_metabolism0.91578543
115MP0002332_abnormal_exercise_endurance0.91164661
116MP0002733_abnormal_thermal_nociception0.90636724
117MP0001968_abnormal_touch/_nociception0.90410819
118MP0003631_nervous_system_phenotype0.89907226
119MP0005409_darkened_coat_color0.89822480
120MP0005595_abnormal_vascular_smooth0.89377797
121MP0002896_abnormal_bone_mineralization0.88749089
122MP0004085_abnormal_heartbeat0.87041017
123MP0001970_abnormal_pain_threshold0.86799679
124MP0005386_behavior/neurological_phenoty0.85614350
125MP0004924_abnormal_behavior0.85614350
126MP0003137_abnormal_impulse_conducting0.84863283
127MP0001756_abnormal_urination0.84710735
128MP0001324_abnormal_eye_pigmentation0.82636858
129MP0005584_abnormal_enzyme/coenzyme_acti0.82568731
130MP0005369_muscle_phenotype0.82305416
131MP0002106_abnormal_muscle_physiology0.81695431
132MP0003632_abnormal_nervous_system0.81630053
133MP0003953_abnormal_hormone_level0.81542888
134MP0005666_abnormal_adipose_tissue0.81486201
135MP0004272_abnormal_basement_membrane0.81321991
136MP0002108_abnormal_muscle_morphology0.81247289
137MP0005508_abnormal_skeleton_morphology0.80110120
138MP0001299_abnormal_eye_distance/0.79949149
139MP0002972_abnormal_cardiac_muscle0.79859722
140MP0004811_abnormal_neuron_physiology0.79049617
141MP0001177_atelectasis0.79035332
142MP0008260_abnormal_autophagy0.77108208
143MP0001542_abnormal_bone_strength0.75997567
144MP0005166_decreased_susceptibility_to0.75759822
145MP0005623_abnormal_meninges_morphology0.73218924

Predicted human phenotypes

RankGene SetZ-score
1Ketoacidosis (HP:0001993)3.80343106
2Asymmetric septal hypertrophy (HP:0001670)3.65338287
3Protrusio acetabuli (HP:0003179)3.58587204
4Congenital stationary night blindness (HP:0007642)3.56879296
5Central scotoma (HP:0000603)3.42415685
6Neurofibrillary tangles (HP:0002185)3.33444195
7Retinal atrophy (HP:0001105)3.24319314
8Type 1 muscle fiber predominance (HP:0003803)3.22143935
9Hypoglycemic seizures (HP:0002173)3.17824520
10Bundle branch block (HP:0011710)3.09197841
11Hypoglycemic coma (HP:0001325)3.08297999
12Hyperinsulinemic hypoglycemia (HP:0000825)3.07636159
13Ketosis (HP:0001946)3.01752311
14Obstructive sleep apnea (HP:0002870)2.98992684
15Hyporeflexia of lower limbs (HP:0002600)2.87442218
16Abnormality of aromatic amino acid family metabolism (HP:0004338)2.82208408
17Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.81750711
18Increased variability in muscle fiber diameter (HP:0003557)2.80236727
19Dysostosis multiplex (HP:0000943)2.78377894
20Muscle fiber splitting (HP:0003555)2.77948568
21Abnormal rod and cone electroretinograms (HP:0008323)2.75510042
22Vertebral compression fractures (HP:0002953)2.75176139
23Abnormality of binocular vision (HP:0011514)2.73773364
24Diplopia (HP:0000651)2.73773364
25Atrioventricular block (HP:0001678)2.72164359
26Increased circulating renin level (HP:0000848)2.70838212
27Scotoma (HP:0000575)2.67696489
28Visual hallucinations (HP:0002367)2.63798036
29Abnormal atrioventricular conduction (HP:0005150)2.62306546
30Abnormality of macular pigmentation (HP:0008002)2.59505374
31Abnormality of complement system (HP:0005339)2.56549925
32Supranuclear gaze palsy (HP:0000605)2.55347501
33Symptomatic seizures (HP:0011145)2.54420989
34Focal seizures (HP:0007359)2.52982962
35Cerebral aneurysm (HP:0004944)2.52574730
36Complement deficiency (HP:0004431)2.52137729
37Heart block (HP:0012722)2.50679100
38Cerebral inclusion bodies (HP:0100314)2.50309262
39Abnormality of skeletal muscle fiber size (HP:0012084)2.50272497
40Decreased circulating renin level (HP:0003351)2.49855119
41Foot dorsiflexor weakness (HP:0009027)2.49124356
42Bony spicule pigmentary retinopathy (HP:0007737)2.48906083
43Depression (HP:0000716)2.42317545
44Abolished electroretinogram (ERG) (HP:0000550)2.41077623
45Premature rupture of membranes (HP:0001788)2.37972187
46Increased connective tissue (HP:0009025)2.37909862
47Urinary glycosaminoglycan excretion (HP:0003541)2.37737221
48Mucopolysacchariduria (HP:0008155)2.37737221
49Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33740901
50Pheochromocytoma (HP:0002666)2.33154483
51Centrally nucleated skeletal muscle fibers (HP:0003687)2.32191925
52Abnormality of mucopolysaccharide metabolism (HP:0011020)2.31885478
53Abnormality of polysaccharide metabolism (HP:0011012)2.31885478
54Abnormality of glycosaminoglycan metabolism (HP:0004371)2.31885478
55Systemic lupus erythematosus (HP:0002725)2.31603045
56Aplasia involving bones of the extremities (HP:0009825)2.31380289
57Aplasia involving bones of the upper limbs (HP:0009823)2.31380289
58Aplasia of the phalanges of the hand (HP:0009802)2.31380289
59Hyperaldosteronism (HP:0000859)2.30992975
60Abnormal eating behavior (HP:0100738)2.30931177
61Distal lower limb muscle weakness (HP:0009053)2.27874547
62Abnormality of the foot musculature (HP:0001436)2.27707356
63Shallow orbits (HP:0000586)2.26946158
64Increased cerebral lipofuscin (HP:0011813)2.26219315
65Spinal rigidity (HP:0003306)2.25613496
66Abnormality of renin-angiotensin system (HP:0000847)2.25456371
67Hypokalemic alkalosis (HP:0001949)2.25040366
68Gout (HP:0001997)2.22260042
69Axonal loss (HP:0003447)2.20996283
70Abnormality of liposaccharide metabolism (HP:0010968)2.20905595
71Abnormality of glycosphingolipid metabolism (HP:0004343)2.20905595
72Abnormality of glycolipid metabolism (HP:0010969)2.20905595
73Hemiparesis (HP:0001269)2.19791871
74Sudden death (HP:0001699)2.19611152
75Epileptic encephalopathy (HP:0200134)2.18941756
76Keratoconus (HP:0000563)2.18531098
77Increased corneal curvature (HP:0100692)2.18531098
78Increased neuronal autofluorescent lipopigment (HP:0002074)2.16930222
79Neuronal loss in central nervous system (HP:0002529)2.16814821
80Myoglobinuria (HP:0002913)2.16632505
81Focal motor seizures (HP:0011153)2.15497496
82Xanthomatosis (HP:0000991)2.15451753
83Late onset (HP:0003584)2.13990265
84Muscle fiber inclusion bodies (HP:0100299)2.13600153
85Truncal ataxia (HP:0002078)2.13529053
86Turricephaly (HP:0000262)2.11651941
87Absent rod-and cone-mediated responses on ERG (HP:0007688)2.11637045
88Postural instability (HP:0002172)2.11375288
89EMG: myopathic abnormalities (HP:0003458)2.11290498
90Nemaline bodies (HP:0003798)2.10526072
91Annular pancreas (HP:0001734)2.10458665
92Aortic aneurysm (HP:0004942)2.09939907
93Large for gestational age (HP:0001520)2.08933950
94Hyperlipoproteinemia (HP:0010980)2.08413660
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.08369262
96Peripheral hypomyelination (HP:0007182)2.07266981
97Febrile seizures (HP:0002373)2.07162173
98Mutism (HP:0002300)2.06954164
99Abnormality of calcium-phosphate metabolism (HP:0100530)2.06831901
100Scanning speech (HP:0002168)2.04728668
101Broad metatarsal (HP:0001783)2.04599982
102Hypokalemia (HP:0002900)2.04557011
103Nuclear cataract (HP:0100018)2.03947968
104Rigidity (HP:0002063)2.03503432
105Papilledema (HP:0001085)2.02944405
106Action tremor (HP:0002345)2.02736293
107Distal upper limb amyotrophy (HP:0007149)2.02636523
108Upper limb amyotrophy (HP:0009129)2.02636523
109Arterial tortuosity (HP:0005116)2.01698812
110Dysmetria (HP:0001310)1.99695761
111Exercise-induced myalgia (HP:0003738)1.99609445
112Focal dystonia (HP:0004373)1.99036885
113Anxiety (HP:0000739)1.98652245
114Ankle clonus (HP:0011448)1.98270186
115Glomerulonephritis (HP:0000099)1.97928513
116Atonic seizures (HP:0010819)1.96577936
117EEG with generalized epileptiform discharges (HP:0011198)1.96427505
118Agitation (HP:0000713)1.95286010
119Myokymia (HP:0002411)1.94976696
120Wormian bones (HP:0002645)1.94376745
121Torticollis (HP:0000473)1.93967737
122Rapidly progressive (HP:0003678)1.93523293
123Hypoplasia of the iris (HP:0007676)1.93483251
124Tetraplegia (HP:0002445)1.92504603
125Intention tremor (HP:0002080)1.92426943
126Neuroendocrine neoplasm (HP:0100634)1.92138487
127Pigmentary retinal degeneration (HP:0001146)1.91318904
128Renal salt wasting (HP:0000127)1.89586416
129Exercise-induced muscle cramps (HP:0003710)1.89285473
130Hyperglycinuria (HP:0003108)1.88767510
131Megalencephaly (HP:0001355)1.88493091
132Epileptiform EEG discharges (HP:0011182)1.87679714
133Abnormality of fatty-acid metabolism (HP:0004359)1.87301713
134Round ear (HP:0100830)1.87269999
135Hammertoe (HP:0001765)1.87230425
136Lower limb amyotrophy (HP:0007210)1.86985760
137Insomnia (HP:0100785)1.85839104
138Apathy (HP:0000741)1.85137041
139Metabolic alkalosis (HP:0200114)1.84706988
140Lower limb muscle weakness (HP:0007340)1.84567127
141Cervical subluxation (HP:0003308)1.84119898
142Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.83770318
143Spastic gait (HP:0002064)1.82756420
144Myopathic facies (HP:0002058)1.82329855
145Retinal dysplasia (HP:0007973)1.81663780
146Adrenal overactivity (HP:0002717)1.81622119
147Neck muscle weakness (HP:0000467)1.81561073
148Type II lissencephaly (HP:0007260)1.81221911
149Humeroradial synostosis (HP:0003041)1.80786580
150Synostosis involving the elbow (HP:0003938)1.80786580
151Mildly elevated creatine phosphokinase (HP:0008180)1.80344814
152Muscle stiffness (HP:0003552)1.79562228
153Decreased central vision (HP:0007663)1.79510997
154Diminished motivation (HP:0000745)1.79498477
155Vascular tortuosity (HP:0004948)1.79468853
156Progressive neurologic deterioration (HP:0002344)1.78838959
157Difficulty running (HP:0009046)1.77759180
158Hypsarrhythmia (HP:0002521)1.77016885
159Dysdiadochokinesis (HP:0002075)1.76012918
160Abnormal urine output (HP:0012590)1.75846238
161Hypoalphalipoproteinemia (HP:0003233)1.75081093
162Generalized tonic-clonic seizures (HP:0002069)1.74577297
163Amyloidosis (HP:0011034)1.74382753
164Progressive visual loss (HP:0000529)1.74180554
165Abnormality of potassium homeostasis (HP:0011042)1.73821692
166Protuberant abdomen (HP:0001538)1.71943149
167Skin nodule (HP:0200036)1.71544364
168Prolonged QT interval (HP:0001657)1.71518964
169Craniofacial dystonia (HP:0012179)1.71056510

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK153.39565878
2INSRR3.22966645
3WNK32.51959744
4PHKG22.23249733
5PHKG12.23249733
6PRKD32.11414762
7TESK12.07574279
8ERN12.06172252
9BCKDK2.04578666
10PINK11.98400829
11NTRK31.96778625
12NTRK11.93711661
13WNK41.93442481
14TNIK1.81222305
15MAP3K91.71548976
16TRIB31.66974900
17EPHA41.65762371
18CAMKK21.62959972
19TGFBR21.62131359
20TTN1.54650729
21LMTK21.53924802
22RIPK11.52673815
23LATS21.52658208
24PAK61.52563836
25SIK11.52216016
26OXSR11.51694163
27SGK2231.37047358
28SGK4941.37047358
29PAK21.36447029
30KSR21.35356704
31MINK11.27227802
32LIMK11.27115868
33OBSCN1.27094138
34MUSK1.25112763
35MARK11.23224698
36CAMK1G1.22916426
37PAK31.21470920
38STK391.21267822
39CAMKK11.19415824
40MOS1.19131659
41EEF2K1.17529301
42MAP3K111.15842182
43NTRK21.12704275
44MAP3K21.08293708
45MAP2K41.08269857
46PRKCH1.07844836
47HIPK21.06419008
48DAPK21.06287266
49DAPK31.04238027
50WNK11.02412656
51EPHA31.01819455
52FGFR21.00350040
53CDK50.98865860
54CAMK1D0.97114628
55STK380.96644400
56FER0.95955974
57MAPK120.95579122
58MAP3K40.94706677
59DYRK1A0.92056582
60MAP3K10.91105685
61TNK20.91025703
62EPHB10.90870497
63MAP3K130.89351069
64TAOK20.89274449
65PRKD20.86040654
66DMPK0.84970657
67CAMK2D0.84546417
68MAPKAPK30.84496246
69DDR20.82073101
70PDGFRA0.81983133
71IRAK20.81319415
72GRK50.80474801
73PIM20.78940933
74PRKCG0.78864800
75ABL20.78585340
76RET0.78263024
77PRKCE0.77508356
78UHMK10.77443575
79NEK60.75672492
80DAPK10.73594273
81MAP2K70.73458052
82PTK60.73251783
83SCYL20.72985488
84ROCK20.72671143
85BRAF0.71239672
86MAPK70.69309994
87DYRK1B0.68845678
88ARAF0.68425703
89CAMK10.68414448
90PKN10.67462771
91ROCK10.66699515
92CDK150.66292537
93CAMK2A0.66232684
94MAP3K60.65470923
95PIK3CG0.65241015
96PTK20.64678394
97RPS6KA20.64435571
98PRPF4B0.63773137
99PDPK10.62975330
100CAMK2G0.62649364
101CDK11A0.61541654
102TESK20.61057492
103MAPK40.59754078
104GRK70.58731692
105MAPK100.58711195
106PRKAA10.58160144
107MAP2K30.57788972
108CDK180.57768999
109CDC42BPA0.57764711
110MET0.57136481
111SGK20.57087246
112SGK30.55407036
113PRKD10.54470141
114BMX0.54465439
115CDK140.54379417
116CDK190.53332979
117MARK20.53196629
118AKT20.51993774
119PRKAA20.51853504
120PRKCZ0.51184000
121MAP3K30.50068203
122TBK10.49343651
123CAMK2B0.49042866
124MAP2K10.48727706
125PRKACG0.47817948
126ICK0.47572921
127MAPK130.46595848
128MAP3K70.46496877
129MYLK0.46489944
130TIE10.46001884
131FGFR40.45690461
132GRK10.45439100
133MAP2K60.45367338
134PRKACA0.44598667
135PRKG20.43381233
136PASK0.42656515
137MAPKAPK50.42483639
138TYRO30.42188311
139PDK10.42123511

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.77780936
2Maturity onset diabetes of the young_Homo sapiens_hsa049502.42133191
3Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.95794352
4Synaptic vesicle cycle_Homo sapiens_hsa047211.89239478
5Insulin secretion_Homo sapiens_hsa049111.79011944
6GABAergic synapse_Homo sapiens_hsa047271.78871618
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77900372
8Fatty acid metabolism_Homo sapiens_hsa012121.77560951
9Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76718772
10Butanoate metabolism_Homo sapiens_hsa006501.76239694
11Fatty acid degradation_Homo sapiens_hsa000711.74505236
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.69151529
13Nicotine addiction_Homo sapiens_hsa050331.57863586
14Phototransduction_Homo sapiens_hsa047441.54847400
15Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53936036
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.38872257
17Propanoate metabolism_Homo sapiens_hsa006401.37951708
18Circadian entrainment_Homo sapiens_hsa047131.34497870
19Sulfur metabolism_Homo sapiens_hsa009201.32216018
20Fatty acid elongation_Homo sapiens_hsa000621.30042391
21Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.27871904
22Vitamin B6 metabolism_Homo sapiens_hsa007501.27662971
23Bile secretion_Homo sapiens_hsa049761.26491700
24Primary bile acid biosynthesis_Homo sapiens_hsa001201.24827652
25Morphine addiction_Homo sapiens_hsa050321.23802681
26Aldosterone synthesis and secretion_Homo sapiens_hsa049251.21667779
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19101006
28Circadian rhythm_Homo sapiens_hsa047101.17979399
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.17405748
30PPAR signaling pathway_Homo sapiens_hsa033201.15450671
31* Lysosome_Homo sapiens_hsa041421.12400479
32Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.10772410
33GnRH signaling pathway_Homo sapiens_hsa049121.10601843
34Salivary secretion_Homo sapiens_hsa049701.09152138
35Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.08281976
36Tryptophan metabolism_Homo sapiens_hsa003801.07665139
37Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07173688
38ECM-receptor interaction_Homo sapiens_hsa045121.06032124
39Glutamatergic synapse_Homo sapiens_hsa047241.05215442
40Peroxisome_Homo sapiens_hsa041461.04654676
41Cocaine addiction_Homo sapiens_hsa050301.03227702
42Carbohydrate digestion and absorption_Homo sapiens_hsa049731.02038338
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.02026669
44Renin secretion_Homo sapiens_hsa049241.01540219
45ABC transporters_Homo sapiens_hsa020101.01499635
46Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.00692634
472-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98785674
48Phospholipase D signaling pathway_Homo sapiens_hsa040720.98688908
49Collecting duct acid secretion_Homo sapiens_hsa049660.98481593
50Other glycan degradation_Homo sapiens_hsa005110.96829813
51Fatty acid biosynthesis_Homo sapiens_hsa000610.96723089
52Vibrio cholerae infection_Homo sapiens_hsa051100.94600525
53Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.94058371
54Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.93456383
55Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.92914863
56Estrogen signaling pathway_Homo sapiens_hsa049150.90348325
57Melanogenesis_Homo sapiens_hsa049160.89929446
58Olfactory transduction_Homo sapiens_hsa047400.88650479
59Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88442719
60Prion diseases_Homo sapiens_hsa050200.88421288
61Arginine biosynthesis_Homo sapiens_hsa002200.88235986
62Taste transduction_Homo sapiens_hsa047420.83712399
63Glioma_Homo sapiens_hsa052140.83700129
64Gastric acid secretion_Homo sapiens_hsa049710.83465205
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.82699723
66Cholinergic synapse_Homo sapiens_hsa047250.82673408
67AMPK signaling pathway_Homo sapiens_hsa041520.82503001
68Dopaminergic synapse_Homo sapiens_hsa047280.82348539
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.82168825
70Amphetamine addiction_Homo sapiens_hsa050310.82030564
71Complement and coagulation cascades_Homo sapiens_hsa046100.81920514
72Type II diabetes mellitus_Homo sapiens_hsa049300.81781557
73Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.79723761
74Pyruvate metabolism_Homo sapiens_hsa006200.78597397
75Focal adhesion_Homo sapiens_hsa045100.77432506
76VEGF signaling pathway_Homo sapiens_hsa043700.77378285
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.76247362
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75448312
79Insulin signaling pathway_Homo sapiens_hsa049100.74053538
80Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.73640754
81Amoebiasis_Homo sapiens_hsa051460.72588822
82Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.69971795
83Long-term depression_Homo sapiens_hsa047300.69901452
84Cardiac muscle contraction_Homo sapiens_hsa042600.69500766
85Serotonergic synapse_Homo sapiens_hsa047260.69159953
86Longevity regulating pathway - mammal_Homo sapiens_hsa042110.68325476
87Pancreatic secretion_Homo sapiens_hsa049720.67320399
88Endocytosis_Homo sapiens_hsa041440.65679648
89cAMP signaling pathway_Homo sapiens_hsa040240.64807243
90Thyroid hormone synthesis_Homo sapiens_hsa049180.63698701
91Glycerolipid metabolism_Homo sapiens_hsa005610.63213993
92Calcium signaling pathway_Homo sapiens_hsa040200.61725119
93cGMP-PKG signaling pathway_Homo sapiens_hsa040220.61672097
94Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61138246
95Histidine metabolism_Homo sapiens_hsa003400.60737944
96Steroid hormone biosynthesis_Homo sapiens_hsa001400.60519636
97Glucagon signaling pathway_Homo sapiens_hsa049220.59089614
98Oxytocin signaling pathway_Homo sapiens_hsa049210.58623946
99Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.58574779
100Neurotrophin signaling pathway_Homo sapiens_hsa047220.58438116
101Prolactin signaling pathway_Homo sapiens_hsa049170.58102582
102beta-Alanine metabolism_Homo sapiens_hsa004100.57209784
103Long-term potentiation_Homo sapiens_hsa047200.57169231
104Ovarian steroidogenesis_Homo sapiens_hsa049130.56779236
105Pentose phosphate pathway_Homo sapiens_hsa000300.56701946
106Starch and sucrose metabolism_Homo sapiens_hsa005000.56674941
107Dilated cardiomyopathy_Homo sapiens_hsa054140.56511022
108ErbB signaling pathway_Homo sapiens_hsa040120.54123550
109Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53572443
110Carbon metabolism_Homo sapiens_hsa012000.53403324
111Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.53136538
112Gap junction_Homo sapiens_hsa045400.53116254
113Vascular smooth muscle contraction_Homo sapiens_hsa042700.53098607
114Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.53074110
115Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.51530578
116Arginine and proline metabolism_Homo sapiens_hsa003300.51236558
117Tyrosine metabolism_Homo sapiens_hsa003500.50335108
118Glycerophospholipid metabolism_Homo sapiens_hsa005640.49859621
119Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.49491655
120Adipocytokine signaling pathway_Homo sapiens_hsa049200.48514967
121Inositol phosphate metabolism_Homo sapiens_hsa005620.48024959
122Fructose and mannose metabolism_Homo sapiens_hsa000510.47715596
123Protein digestion and absorption_Homo sapiens_hsa049740.47544497
124Rap1 signaling pathway_Homo sapiens_hsa040150.47223934
125Insulin resistance_Homo sapiens_hsa049310.47013116
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.46999800
127Mineral absorption_Homo sapiens_hsa049780.46985612
128Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46873427
129Phenylalanine metabolism_Homo sapiens_hsa003600.46594858
130Protein export_Homo sapiens_hsa030600.45209728
131Ras signaling pathway_Homo sapiens_hsa040140.42652840
132MAPK signaling pathway_Homo sapiens_hsa040100.41730084
133mTOR signaling pathway_Homo sapiens_hsa041500.41707923

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