CTSG

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, a member of the peptidase S1 protein family, is found in azurophil granules of neutrophilic polymorphonuclear leukocytes. The encoded protease has a specificity similar to that of chymotrypsin C, and may participate in the killing and digestion of engulfed pathogens, and in connective tissue remodeling at sites of inflammation. In addition, the encoded protein is antimicrobial, with bacteriocidal activity against S. aureus and N. gonorrhoeae. Transcript variants utilizing alternative polyadenylation signals exist for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)7.57064370
2DNA deamination (GO:0045006)7.29655440
3negative regulation of phagocytosis (GO:0050765)7.01507915
4protoporphyrinogen IX biosynthetic process (GO:0006782)6.45949434
5innate immune response in mucosa (GO:0002227)6.38991918
6regulation of MHC class II biosynthetic process (GO:0045346)6.26602944
7protoporphyrinogen IX metabolic process (GO:0046501)5.86073547
8microglial cell activation (GO:0001774)5.81463790
9antibacterial humoral response (GO:0019731)5.74310697
10regulation of tumor necrosis factor biosynthetic process (GO:0042534)5.67369514
11response to peptidoglycan (GO:0032494)5.66993611
12negative regulation of interleukin-8 production (GO:0032717)5.65621417
13ribosomal small subunit assembly (GO:0000028)5.40123704
14DNA strand elongation involved in DNA replication (GO:0006271)5.31177486
15telomere maintenance via semi-conservative replication (GO:0032201)5.28074558
16antimicrobial humoral response (GO:0019730)5.27220041
17DNA strand elongation (GO:0022616)5.06533615
18positive regulation of chemokine biosynthetic process (GO:0045080)5.01090145
19mucosal immune response (GO:0002385)5.00414225
20pentose-phosphate shunt (GO:0006098)4.94730717
21* negative regulation of growth of symbiont in host (GO:0044130)4.90393736
22* negative regulation of growth of symbiont involved in interaction with host (GO:0044146)4.90393736
23* modulation of growth of symbiont involved in interaction with host (GO:0044144)4.90393736
24* regulation of growth of symbiont in host (GO:0044126)4.90393736
25* disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.90087012
26* killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.90087012
27cellular response to zinc ion (GO:0071294)4.86201808
28organ or tissue specific immune response (GO:0002251)4.84879899
29purine deoxyribonucleotide catabolic process (GO:0009155)4.78815089
30respiratory burst (GO:0045730)4.77598649
31* neutrophil mediated immunity (GO:0002446)4.69383961
32cell wall macromolecule catabolic process (GO:0016998)4.69214775
33reactive oxygen species biosynthetic process (GO:1903409)4.66749594
34SRP-dependent cotranslational protein targeting to membrane (GO:0006614)4.59863422
35NADPH regeneration (GO:0006740)4.58648417
36* response to fungus (GO:0009620)4.53005218
37cotranslational protein targeting to membrane (GO:0006613)4.49144187
38protein targeting to ER (GO:0045047)4.47020268
39viral transcription (GO:0019083)4.46007551
40DNA replication initiation (GO:0006270)4.45698127
41telomere maintenance via recombination (GO:0000722)4.42439621
42translational termination (GO:0006415)4.35663630
43protein localization to endoplasmic reticulum (GO:0070972)4.30198624
44establishment of protein localization to endoplasmic reticulum (GO:0072599)4.25575666
45positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.16403504
46hemoglobin metabolic process (GO:0020027)4.14309988
47DNA unwinding involved in DNA replication (GO:0006268)4.05459298
48* myeloid leukocyte mediated immunity (GO:0002444)4.03686772
49centriole replication (GO:0007099)4.01770174
50DNA replication checkpoint (GO:0000076)4.01238004
51IMP metabolic process (GO:0046040)3.96013171
52mitotic recombination (GO:0006312)3.95019940
53translational elongation (GO:0006414)3.91441550
54cell wall macromolecule metabolic process (GO:0044036)3.86677664
55* defense response to fungus (GO:0050832)3.83747661
56response to muramyl dipeptide (GO:0032495)3.82945148
57macrophage chemotaxis (GO:0048246)3.78239844
58positive regulation of B cell differentiation (GO:0045579)3.77490001
59pentose metabolic process (GO:0019321)3.77131066
60purine deoxyribonucleotide metabolic process (GO:0009151)3.76576896
61negative regulation of erythrocyte differentiation (GO:0045647)3.75828226
62ribosomal small subunit biogenesis (GO:0042274)3.74606745
63glucose 6-phosphate metabolic process (GO:0051156)3.74325004
64telomere maintenance via telomere lengthening (GO:0010833)3.71271383
65antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.65758378
66antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.65758378
67nucleobase biosynthetic process (GO:0046112)3.62796074
68glial cell migration (GO:0008347)3.62682014
69Arp2/3 complex-mediated actin nucleation (GO:0034314)3.58736981
70ribosome assembly (GO:0042255)3.58579246
71* disruption of cells of other organism (GO:0044364)3.57516685
72* killing of cells of other organism (GO:0031640)3.57516685
73pseudouridine synthesis (GO:0001522)3.57211971
74macrophage activation (GO:0042116)3.52707392
75low-density lipoprotein particle remodeling (GO:0034374)3.48780194
76neutrophil activation (GO:0042119)3.46532002
77IMP biosynthetic process (GO:0006188)3.42332277
78maturation of SSU-rRNA (GO:0030490)3.41145582
79translational initiation (GO:0006413)3.38841771
80glucose catabolic process (GO:0006007)3.38601571
81cellular protein complex disassembly (GO:0043624)3.37107564
82positive regulation of gamma-delta T cell activation (GO:0046645)3.33937415
83defense response to Gram-positive bacterium (GO:0050830)3.31598511
84nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.31417537
85regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.30493619
86induction of positive chemotaxis (GO:0050930)3.28949917
87nucleotide-excision repair, DNA gap filling (GO:0006297)3.27970538
88viral life cycle (GO:0019058)3.24463496
89hydrogen peroxide metabolic process (GO:0042743)3.24435180
90regulation of phagocytosis (GO:0050764)3.23816997
91deoxyribose phosphate catabolic process (GO:0046386)3.18027060
92negative regulation of bone mineralization (GO:0030502)3.17905626
93signal peptide processing (GO:0006465)3.17707416
94hydrogen peroxide catabolic process (GO:0042744)3.15939437
95UV protection (GO:0009650)3.15802594
96deoxyribonucleotide catabolic process (GO:0009264)3.15675756
97porphyrin-containing compound biosynthetic process (GO:0006779)3.14501567
98macrophage differentiation (GO:0030225)3.13231074
99defense response to bacterium (GO:0042742)3.10352973
100regulation of cellular respiration (GO:0043457)3.08795060
101deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.06923151
102definitive hemopoiesis (GO:0060216)3.06544057
103neutrophil activation involved in immune response (GO:0002283)3.06440765
104secretory granule organization (GO:0033363)3.05479841
105G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.05463193
106centriole assembly (GO:0098534)3.04552585
107purine nucleobase biosynthetic process (GO:0009113)3.02505050
108fucose catabolic process (GO:0019317)3.01369889
109L-fucose metabolic process (GO:0042354)3.01369889
110L-fucose catabolic process (GO:0042355)3.01369889
111protein localization to kinetochore (GO:0034501)3.00806125
112granulocyte activation (GO:0036230)3.00259984
113translation (GO:0006412)3.00114629
114removal of superoxide radicals (GO:0019430)3.00033821
115cellular response to superoxide (GO:0071451)3.00033821
116cellular response to oxygen radical (GO:0071450)3.00033821
117positive regulation of histone deacetylation (GO:0031065)3.00020036
118mannose metabolic process (GO:0006013)2.98497883
119leukocyte degranulation (GO:0043299)2.96665037
120protein complex disassembly (GO:0043241)2.95571510
121anterograde synaptic vesicle transport (GO:0048490)2.95409944
122protein targeting to membrane (GO:0006612)2.94892497
123regulation of mast cell degranulation (GO:0043304)2.94883896
124regulation of myeloid leukocyte mediated immunity (GO:0002886)2.94163785
125negative regulation of RNA splicing (GO:0033119)2.92610963
126positive regulation of histone H3-K4 methylation (GO:0051571)2.91595292
127antigen processing and presentation of endogenous antigen (GO:0019883)2.90260149
128regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.88991693
129antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.87668211
130natural killer cell activation involved in immune response (GO:0002323)2.86882232
131nucleobase-containing small molecule interconversion (GO:0015949)2.86519239
132negative regulation of granulocyte differentiation (GO:0030853)2.85878764
133formation of translation preinitiation complex (GO:0001731)2.85314485
134ribosomal large subunit biogenesis (GO:0042273)2.85122684
135mature B cell differentiation involved in immune response (GO:0002313)2.85058952
136poly(A)+ mRNA export from nucleus (GO:0016973)2.84168327
137leukotriene biosynthetic process (GO:0019370)2.83471430
138purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)2.82445826
139base-excision repair, AP site formation (GO:0006285)2.82366221
140ribonucleoprotein complex biogenesis (GO:0022613)2.82080126
141positive regulation of tumor necrosis factor production (GO:0032760)2.81514160
142regulation of interleukin-8 biosynthetic process (GO:0045414)2.77784184
143translesion synthesis (GO:0019985)2.77711910
144macromolecular complex disassembly (GO:0032984)2.77464547
145regulation of protein heterodimerization activity (GO:0043497)2.77096017
146angiogenesis involved in wound healing (GO:0060055)2.75962325
147heme biosynthetic process (GO:0006783)2.75421524
148antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.75282212
149* cell killing (GO:0001906)2.75243216
150negative regulation of biomineral tissue development (GO:0070168)2.73315584
151positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.72657014
152negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.72503309
153regulation of chemokine biosynthetic process (GO:0045073)2.72201093
154exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.70553037
155response to food (GO:0032094)2.70305199
156CENP-A containing nucleosome assembly (GO:0034080)2.70137782
157N-acetylneuraminate metabolic process (GO:0006054)2.69403608
158response to bacterium (GO:0009617)2.68381445
159rRNA processing (GO:0006364)2.67779710
160positive regulation of phagocytosis (GO:0050766)2.67352687
161regulation of mast cell activation involved in immune response (GO:0033006)2.67279815
162negative regulation of chemokine production (GO:0032682)2.66329286
1632-deoxyribonucleotide metabolic process (GO:0009394)2.66139927
164regulation of erythrocyte differentiation (GO:0045646)2.65387410
165purine nucleobase metabolic process (GO:0006144)2.64909245
166nuclear-transcribed mRNA catabolic process (GO:0000956)2.64421703
167pinocytosis (GO:0006907)2.62032330
168chromatin remodeling at centromere (GO:0031055)2.61705033
169cellular extravasation (GO:0045123)10.4105897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.03435776
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.29143011
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.62318222
4* MYB_21317192_ChIP-Seq_ERMYB_Mouse3.08242544
5E2F4_17652178_ChIP-ChIP_JURKAT_Human2.96973540
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.82409587
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.76936313
8* VDR_21846776_ChIP-Seq_THP-1_Human2.76869740
9MYC_18358816_ChIP-ChIP_MESCs_Mouse2.68780191
10NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.65906485
11SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.64357083
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.61422362
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.58228148
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53350274
15CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.48222732
16SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.45536359
17* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.40136801
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.35064818
19VDR_24787735_ChIP-Seq_THP-1_Human2.33576411
20MYC_19030024_ChIP-ChIP_MESCs_Mouse2.33046110
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.28033073
22TAL1_20887958_ChIP-Seq_HPC-7_Mouse2.24092843
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.15329535
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.10901872
25FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.08846572
26MYC_22102868_ChIP-Seq_BL_Human2.05358165
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.04879610
28CREB1_15753290_ChIP-ChIP_HEK293T_Human2.04004136
29VDR_23849224_ChIP-Seq_CD4+_Human2.01807656
30FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94623199
31RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94506879
32* SPI1_23547873_ChIP-Seq_NB4_Human1.93707911
33SCL_19346495_ChIP-Seq_HPC-7_Human1.92135286
34SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.91907899
35XRN2_22483619_ChIP-Seq_HELA_Human1.90921825
36ERG_20887958_ChIP-Seq_HPC-7_Mouse1.88188689
37* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.84007980
38KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.83094098
39* VDR_24763502_ChIP-Seq_THP-1_Human1.82712334
40GATA1_22025678_ChIP-Seq_K562_Human1.82148306
41FOXP3_21729870_ChIP-Seq_TREG_Human1.81970424
42FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.79996357
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.78080570
44DCP1A_22483619_ChIP-Seq_HELA_Human1.75939834
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.71005656
46YY1_21170310_ChIP-Seq_MESCs_Mouse1.68352353
47BRD4_27068464_Chip-Seq_AML-cells_Mouse1.68274173
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.68002969
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.63001151
50MAF_26560356_Chip-Seq_TH2_Human1.61580406
51FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.61025026
52CIITA_25753668_ChIP-Seq_RAJI_Human1.59974986
53SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.59761339
54GABP_19822575_ChIP-Seq_HepG2_Human1.58033361
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.56028465
56IRF8_21731497_ChIP-ChIP_J774_Mouse1.55114377
57IKZF1_21737484_ChIP-ChIP_HCT116_Human1.53008349
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.52368730
59LXR_22292898_ChIP-Seq_THP-1_Human1.50791525
60SPI1_23127762_ChIP-Seq_K562_Human1.50287503
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.46323616
62GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.45133020
63THAP11_20581084_ChIP-Seq_MESCs_Mouse1.45089030
64SRF_21415370_ChIP-Seq_HL-1_Mouse1.44635077
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.44537317
66ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42716211
67MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42161256
68TTF2_22483619_ChIP-Seq_HELA_Human1.41727749
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41144431
70TCF7_22412390_ChIP-Seq_EML_Mouse1.41125949
71PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39441951
72GATA1_22383799_ChIP-Seq_G1ME_Mouse1.38711339
73E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.38003624
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36883418
75AR_21909140_ChIP-Seq_LNCAP_Human1.36145357
76PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.35099508
77CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35016162
78NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34535882
79CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.33894115
80MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31813294
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31776986
82MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29745408
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.29345112
84GATA1_19941827_ChIP-Seq_MEL_Mouse1.27315686
85ELK1_19687146_ChIP-ChIP_HELA_Human1.27139093
86ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.24463556
87TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.24217943
88GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24209372
89SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23776734
90MYB_26560356_Chip-Seq_TH2_Human1.23729674
91STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23176723
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.22832793
93BCL6_27268052_Chip-Seq_Bcells_Human1.21963777
94PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.19019078
95IGF1R_20145208_ChIP-Seq_DFB_Human1.18486115
96ELF1_20517297_ChIP-Seq_JURKAT_Human1.17693022
97E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17482777
98GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.16710822
99KDM2B_26808549_Chip-Seq_DND41_Human1.16550445
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.14811040
101MYB_26560356_Chip-Seq_TH1_Human1.12501684
102UTX_26944678_Chip-Seq_JUKART_Human1.12097451
103CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.11963610
104NCOR1_26117541_ChIP-Seq_K562_Human1.11156948
105LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11049166
106KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.09572502
107MAF_26560356_Chip-Seq_TH1_Human1.09182980
108BP1_19119308_ChIP-ChIP_Hs578T_Human1.08559278
109GATA1_19941826_ChIP-Seq_K562_Human1.08496426
110RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05636438
111LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.05010703
112POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.04629677
113GATA2_22383799_ChIP-Seq_G1ME_Mouse1.04117643
114KDM5A_27292631_Chip-Seq_BREAST_Human1.03762083
115* ETS1_22383799_ChIP-Seq_G1ME_Mouse1.01601917
116FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00563030
117BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00447118
118CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.99549988
119CTCF_27219007_Chip-Seq_ERYTHROID_Human0.98427969
120GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98179650
121CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98028585
122TFEB_21752829_ChIP-Seq_HELA_Human0.97512992
123KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95373966
124* PU_27001747_Chip-Seq_BMDM_Mouse0.95105688
125NOTCH1_21737748_ChIP-Seq_TLL_Human0.94552709
126BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.93458111
127MYC_18940864_ChIP-ChIP_HL60_Human0.93206341
128ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.93130425
129GATA3_26560356_Chip-Seq_TH2_Human0.92932026
130VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.92427814
131PU.1_20513432_ChIP-Seq_Bcells_Mouse0.91394171
132BCOR_27268052_Chip-Seq_Bcells_Human0.90790596
133PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90631224
134SPI1_20517297_ChIP-Seq_HL60_Human0.90375279
135YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.90325527
136IRF8_27001747_Chip-Seq_BMDM_Mouse0.90258443
137P68_20966046_ChIP-Seq_HELA_Human0.89863807
138* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.89550256
139Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.89008203
140TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88196355
141PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87365328

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005083_abnormal_biliary_tract4.60105521
2MP0002396_abnormal_hematopoietic_system4.19738104
3MP0003693_abnormal_embryo_hatching4.01389226
4MP0000569_abnormal_digit_pigmentation3.58363961
5MP0003303_peritoneal_inflammation3.48404983
6MP0010094_abnormal_chromosome_stability2.92654327
7MP0008057_abnormal_DNA_replication2.80361745
8MP0003436_decreased_susceptibility_to2.74665946
9MP0005174_abnormal_tail_pigmentation2.74605478
10MP0003172_abnormal_lysosome_physiology2.73476146
11MP0002419_abnormal_innate_immunity2.72664870
12MP0001835_abnormal_antigen_presentation2.63237171
13MP0009278_abnormal_bone_marrow2.61745164
14MP0009379_abnormal_foot_pigmentation2.61163235
15MP0004957_abnormal_blastocyst_morpholog2.60296634
16MP0002166_altered_tumor_susceptibility2.56265224
17MP0003183_abnormal_peptide_metabolism2.52839547
18MP0003724_increased_susceptibility_to2.46159068
19MP0000465_gastrointestinal_hemorrhage2.45762005
20MP0003111_abnormal_nucleus_morphology2.45457846
21MP0000490_abnormal_crypts_of2.38709515
22MP0009785_altered_susceptibility_to2.27814449
23MP0005075_abnormal_melanosome_morpholog2.26024722
24* MP0005025_abnormal_response_to2.24390446
25MP0003077_abnormal_cell_cycle2.22526065
26MP0008961_abnormal_basal_metabolism2.21683580
27MP0005464_abnormal_platelet_physiology2.14696087
28MP0002009_preneoplasia2.13618858
29MP0008058_abnormal_DNA_repair2.07371338
30MP0002148_abnormal_hypersensitivity_rea2.05704580
31MP0005076_abnormal_cell_differentiation2.04947482
32MP0002006_tumorigenesis2.00623748
33MP0001853_heart_inflammation1.98483594
34MP0009333_abnormal_splenocyte_physiolog1.96766321
35MP0002420_abnormal_adaptive_immunity1.91535506
36MP0001545_abnormal_hematopoietic_system1.90888786
37MP0005397_hematopoietic_system_phenotyp1.90888786
38MP0001819_abnormal_immune_cell1.87092703
39MP0004808_abnormal_hematopoietic_stem1.86837530
40MP0000858_altered_metastatic_potential1.83718045
41MP0005000_abnormal_immune_tolerance1.81451818
42MP0004185_abnormal_adipocyte_glucose1.79207933
43* MP0002398_abnormal_bone_marrow1.72304925
44MP0000015_abnormal_ear_pigmentation1.69801201
45* MP0000716_abnormal_immune_system1.66027957
46MP0010307_abnormal_tumor_latency1.63956012
47MP0002095_abnormal_skin_pigmentation1.57628729
48* MP0002429_abnormal_blood_cell1.55645251
49MP0008007_abnormal_cellular_replicative1.55385779
50MP0003763_abnormal_thymus_physiology1.53672713
51MP0002723_abnormal_immune_serum1.53139679
52MP0005671_abnormal_response_to1.51960608
53MP0002452_abnormal_antigen_presenting1.51804113
54MP0003221_abnormal_cardiomyocyte_apopto1.47983222
55* MP0002722_abnormal_immune_system1.46581579
56MP0006082_CNS_inflammation1.45793953
57MP0004782_abnormal_surfactant_physiolog1.40298283
58* MP0000689_abnormal_spleen_morphology1.40096775
59MP0001800_abnormal_humoral_immune1.39466600
60MP0000685_abnormal_immune_system1.38585380
61MP0001533_abnormal_skeleton_physiology1.34126433
62MP0001873_stomach_inflammation1.34067667
63MP0006036_abnormal_mitochondrial_physio1.32171057
64* MP0001845_abnormal_inflammatory_respons1.31321087
65MP0003828_pulmonary_edema1.31244036
66* MP0002019_abnormal_tumor_incidence1.30805103
67MP0010155_abnormal_intestine_physiology1.29961864
68MP0002405_respiratory_system_inflammati1.27421772
69MP0003186_abnormal_redox_activity1.26638776
70MP0001986_abnormal_taste_sensitivity1.26306287
71MP0003866_abnormal_defecation1.22858684
72MP0004742_abnormal_vestibular_system1.19202555
73MP0005666_abnormal_adipose_tissue1.18724866
74MP0005058_abnormal_lysosome_morphology1.17546657
75MP0001663_abnormal_digestive_system1.16971713
76MP0003252_abnormal_bile_duct1.16187822
77MP0006054_spinal_hemorrhage1.16040022
78MP0005360_urolithiasis1.15676483
79MP0000703_abnormal_thymus_morphology1.12638493
80MP0000358_abnormal_cell_content/1.10452036
81MP0005220_abnormal_exocrine_pancreas1.09595382
82MP0008469_abnormal_protein_level1.09544130
83MP0000343_altered_response_to1.07367756
84MP0008873_increased_physiological_sensi1.06581470
85MP0005409_darkened_coat_color1.06058728
86MP0005670_abnormal_white_adipose1.05844246
87MP0008932_abnormal_embryonic_tissue1.01821680
88MP0000350_abnormal_cell_proliferation0.98608092
89MP0000313_abnormal_cell_death0.98014136
90MP0004381_abnormal_hair_follicle0.97801115
91MP0003646_muscle_fatigue0.97780783
92MP0009764_decreased_sensitivity_to0.97527594
93MP0005389_reproductive_system_phenotype0.96188438
94MP0002877_abnormal_melanocyte_morpholog0.96119112
95MP0001851_eye_inflammation0.95101316
96MP0002160_abnormal_reproductive_system0.95046454
97MP0005164_abnormal_response_to0.95034119
98MP0003786_premature_aging0.94623009
99MP0008995_early_reproductive_senescence0.92289652
100MP0004947_skin_inflammation0.90074522
101MP0001764_abnormal_homeostasis0.89626427
102MP0005408_hypopigmentation0.88017757
103MP0005319_abnormal_enzyme/_coenzyme0.87329815
104MP0004147_increased_porphyrin_level0.86909742
105MP0003656_abnormal_erythrocyte_physiolo0.85432172
106MP0003300_gastrointestinal_ulcer0.84340587
107MP0005375_adipose_tissue_phenotype0.83909449
108MP0005365_abnormal_bile_salt0.83234622
109MP0002970_abnormal_white_adipose0.82189266
110MP0005266_abnormal_metabolism0.81036406
111MP0009763_increased_sensitivity_to0.79109552
112MP0003191_abnormal_cellular_cholesterol0.78457211
113MP0010352_gastrointestinal_tract_polyps0.78318431
114MP0000249_abnormal_blood_vessel0.78316406
115MP0009115_abnormal_fat_cell0.77863868
116MP0000681_abnormal_thyroid_gland0.76683825
117* MP0000598_abnormal_liver_morphology0.76046984
118MP0003638_abnormal_response/metabolism_0.75256262
119MP0001730_embryonic_growth_arrest0.74142579
120MP0009931_abnormal_skin_appearance0.73071965
121MP0006035_abnormal_mitochondrial_morpho0.71119692
122MP0005334_abnormal_fat_pad0.69940489
123MP0005387_immune_system_phenotype0.69813752
124MP0001790_abnormal_immune_system0.69813752
125MP0003075_altered_response_to0.69672021
126MP0009765_abnormal_xenobiotic_induced0.67888467
127MP0002132_abnormal_respiratory_system0.66749198
128MP0002080_prenatal_lethality0.66513846
129MP0000371_diluted_coat_color0.66426357
130MP0005376_homeostasis/metabolism_phenot0.65788631
131MP0003123_paternal_imprinting0.63004035
132MP0005384_cellular_phenotype0.62912850
133MP0005584_abnormal_enzyme/coenzyme_acti0.62684731
134MP0004264_abnormal_extraembryonic_tissu0.62599293
135MP0003448_altered_tumor_morphology0.61609305
136MP0002075_abnormal_coat/hair_pigmentati0.61176684

Predicted human phenotypes

RankGene SetZ-score
1Thrombocytosis (HP:0001894)6.90429663
2Reduced antithrombin III activity (HP:0001976)5.44386165
3Abnormal number of erythroid precursors (HP:0012131)5.01573756
4Abnormality of cells of the erythroid lineage (HP:0012130)4.95538481
5Abnormality of the prostate (HP:0008775)4.63059643
6Chronic obstructive pulmonary disease (HP:0006510)4.46317179
7Obstructive lung disease (HP:0006536)4.46317179
8Type I transferrin isoform profile (HP:0003642)4.43230355
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.38732145
10Elevated erythrocyte sedimentation rate (HP:0003565)4.34728067
11Abnormality of the heme biosynthetic pathway (HP:0010472)4.27265262
12Reticulocytopenia (HP:0001896)4.01384746
13Hypochromic microcytic anemia (HP:0004840)3.90269166
14Aplastic anemia (HP:0001915)3.89689779
15Amyloidosis (HP:0011034)3.86456332
16Acute lymphatic leukemia (HP:0006721)3.85195561
17Chest pain (HP:0100749)3.84582850
18Increased cerebral lipofuscin (HP:0011813)3.78688279
19Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.62607334
20Abnormal protein N-linked glycosylation (HP:0012347)3.62607334
21Abnormal protein glycosylation (HP:0012346)3.62607334
22Abnormal glycosylation (HP:0012345)3.62607334
23Recurrent abscess formation (HP:0002722)3.61042657
24Recurrent bacterial skin infections (HP:0005406)3.48086114
25Pulmonary fibrosis (HP:0002206)3.39291753
26Spondylolisthesis (HP:0003302)3.37344024
27Eczematoid dermatitis (HP:0000976)3.36812400
28Recurrent cutaneous fungal infections (HP:0011370)3.31244663
29Chronic mucocutaneous candidiasis (HP:0002728)3.31244663
30Myositis (HP:0100614)3.30100336
31Hepatosplenomegaly (HP:0001433)3.25167326
32Ureteral stenosis (HP:0000071)3.22667896
33Chronic otitis media (HP:0000389)3.13597280
34Abnormal delayed hypersensitivity skin test (HP:0002963)3.06472416
35Periodontitis (HP:0000704)3.06075459
36Meningitis (HP:0001287)3.00317390
37Oral leukoplakia (HP:0002745)2.98665700
38Recurrent fungal infections (HP:0002841)2.95521536
39Hypochromic anemia (HP:0001931)2.93343831
40IgM deficiency (HP:0002850)2.86884413
41Abnormality of the thoracic spine (HP:0100711)2.84792819
42Dysostosis multiplex (HP:0000943)2.83497647
43Papilledema (HP:0001085)2.82005119
44Ureteral obstruction (HP:0006000)2.80134968
45Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.78491116
46Granulocytopenia (HP:0001913)2.78466774
47Eosinophilia (HP:0001880)2.76811186
48Thoracic kyphosis (HP:0002942)2.73640890
49Hemoptysis (HP:0002105)2.66906841
50Vitreoretinal degeneration (HP:0000655)2.66413876
51Petechiae (HP:0000967)2.63659929
52Paralysis (HP:0003470)2.60745820
53Abnormality of B cell number (HP:0010975)2.59500018
54B lymphocytopenia (HP:0010976)2.59500018
55Macrocytic anemia (HP:0001972)2.56439402
56Hepatic necrosis (HP:0002605)2.53980394
57Abnormality of T cell physiology (HP:0011840)2.53396562
58Gangrene (HP:0100758)2.51093531
59Abnormality of the pleura (HP:0002103)2.46372432
60Stomatitis (HP:0010280)2.42918767
61Sepsis (HP:0100806)2.40209190
62Loss of speech (HP:0002371)2.39565211
63J-shaped sella turcica (HP:0002680)2.39238710
64Gingivitis (HP:0000230)2.35886306
65Pulmonary infiltrates (HP:0002113)2.35351588
66Epistaxis (HP:0000421)2.34820107
67Mediastinal lymphadenopathy (HP:0100721)2.34688576
68Poikiloderma (HP:0001029)2.34118101
69Birth length less than 3rd percentile (HP:0003561)2.33783347
70Pallor (HP:0000980)2.30952475
71Abnormality of iron homeostasis (HP:0011031)2.30039833
72Hypergammaglobulinemia (HP:0010702)2.29552423
73Severe visual impairment (HP:0001141)2.27466438
74Multiple enchondromatosis (HP:0005701)2.27004971
75Microcytic anemia (HP:0001935)2.26990186
76Annular pancreas (HP:0001734)2.26944743
77Prolonged bleeding time (HP:0003010)2.26486128
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.26334338
79Hepatocellular necrosis (HP:0001404)2.26199030
80Paresthesia (HP:0003401)2.24476052
81Poikilocytosis (HP:0004447)2.23654059
82Abnormal platelet function (HP:0011869)2.23580817
83Impaired platelet aggregation (HP:0003540)2.23580817
84Recurrent skin infections (HP:0001581)2.23564698
85Generalized hyperpigmentation (HP:0007440)2.23241223
86Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.20943880
87Agnosia (HP:0010524)2.20151123
88Increased hepatocellular lipid droplets (HP:0006565)2.20076733
89Pancytopenia (HP:0001876)2.18844568
90Recurrent gram-negative bacterial infections (HP:0005420)2.18404215
91Abnormality of male internal genitalia (HP:0000022)2.18283433
92Cutaneous photosensitivity (HP:0000992)2.18129640
93Abnormality of the lumbar spine (HP:0100712)2.16855153
94Autoimmune thrombocytopenia (HP:0001973)2.16117925
95Neutropenia (HP:0001875)2.15142625
96Poor head control (HP:0002421)2.14719903
97Microvesicular hepatic steatosis (HP:0001414)2.14082705
98Generalized aminoaciduria (HP:0002909)2.12783243
99Exertional dyspnea (HP:0002875)2.12610922
100Vasculitis (HP:0002633)2.12557646
101Thrombophlebitis (HP:0004418)2.12251843
102Agammaglobulinemia (HP:0004432)2.11892934
103Increased serum ferritin (HP:0003281)2.11804468
104Cellulitis (HP:0100658)2.11503223
105Progressive microcephaly (HP:0000253)2.06743861
106Lipid accumulation in hepatocytes (HP:0006561)2.06624811
107Amaurosis fugax (HP:0100576)2.04626563
108Ocular albinism (HP:0001107)2.02014063
109Osteomyelitis (HP:0002754)2.01965522
110Skin rash (HP:0000988)1.98374864
111Restrictive lung disease (HP:0002091)1.98149825
112Microretrognathia (HP:0000308)1.98092601
113Bone marrow hypocellularity (HP:0005528)1.97984978
114Increased intramyocellular lipid droplets (HP:0012240)1.97565067
115Urticaria (HP:0001025)1.97407552
116Skin ulcer (HP:0200042)1.96877701
117Hypoplasia of the thymus (HP:0000778)1.96802814
118Porencephaly (HP:0002132)1.92633163
119Premature graying of hair (HP:0002216)1.92327637
120Recurrent viral infections (HP:0004429)1.91467229
12111 pairs of ribs (HP:0000878)1.90779791
122Gingival bleeding (HP:0000225)1.90520825
123Spinal canal stenosis (HP:0003416)1.90171947
124Abnormality of eosinophils (HP:0001879)1.89336182
125Prostate neoplasm (HP:0100787)1.88824722
126Progressive muscle weakness (HP:0003323)1.88769664
127Abnormality of the columella (HP:0009929)1.87353345
128Increased muscle lipid content (HP:0009058)1.87204234
129Arterial thrombosis (HP:0004420)1.86329919
130Myelodysplasia (HP:0002863)1.85830425
131Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.85256009
132Abnormality of macrophages (HP:0004311)1.85115254
133Pustule (HP:0200039)1.84590206
134Glomerulopathy (HP:0100820)1.84029630
135Acute myeloid leukemia (HP:0004808)1.83015670
136Pulmonary embolism (HP:0002204)1.82200609
137Aplasia/Hypoplasia of the thymus (HP:0010515)1.81026120
138Polyneuropathy (HP:0001271)1.80994080
139Vacuolated lymphocytes (HP:0001922)1.80298821
140Iris hypopigmentation (HP:0007730)1.80196504
141Abnormality of transition element cation homeostasis (HP:0011030)1.79404356
142Rough bone trabeculation (HP:0100670)1.79137830
143Increased serum lactate (HP:0002151)1.78789362
144Albinism (HP:0001022)1.78721209
145Leukocytosis (HP:0001974)1.78507558
146Abnormal hemoglobin (HP:0011902)1.77907771
147Abnormality of the pericardium (HP:0001697)1.77284078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK35.40557527
2STK164.90627316
3WEE12.88252749
4IRAK42.82424964
5SCYL22.81372894
6TEC2.57225271
7CAMK1D2.51236272
8FES2.49404805
9CDC72.35590064
10PIM22.31828313
11MAP3K122.30725434
12VRK12.28217106
13TRPM72.17145452
14TAOK32.15766886
15CAMKK22.00206087
16TNIK1.98088026
17TESK21.92349627
18BLK1.89826114
19BTK1.87028618
20CAMK1G1.86981177
21PRPF4B1.86428766
22VRK21.81421915
23BUB11.80433229
24PKN21.71141011
25ERN11.69788851
26MAP2K31.64321310
27SMG11.55894393
28EEF2K1.53016837
29CDK61.46988116
30MAP4K11.43860933
31CDK191.43061537
32EIF2AK11.43033373
33KIT1.40726515
34EIF2AK21.39311309
35FLT31.37812954
36DAPK11.30385480
37TESK11.26991409
38TNK21.26060830
39MKNK11.20181422
40CDK81.18060331
41MKNK21.17383450
42BRSK21.15661520
43ATR1.12945094
44NEK21.12130671
45TRIB31.11006298
46ACVR1B1.10868338
47CDK71.10470151
48KDR1.09397037
49RPS6KB21.07868600
50PAK41.05037343
51SYK1.02088649
52MAP3K141.01674491
53LRRK20.98486617
54RIPK40.97333731
55CDK120.95541494
56MAPK120.95227731
57MAP3K60.94784931
58NUAK10.93364000
59HIPK20.93339378
60NME20.93175043
61SRPK10.93011309
62MYLK0.90657771
63TSSK60.89643737
64DYRK30.88593153
65MAPK40.87067857
66BCKDK0.86596519
67CDK40.84376929
68IRAK30.82811436
69RAF10.82757660
70MAPKAPK30.80996197
71ABL20.79934677
72ILK0.78492429
73IKBKE0.77180295
74ITK0.76924320
75MAP3K80.76181398
76MAP3K110.75295509
77AURKB0.72818407
78LIMK10.71895216
79LYN0.71814126
80MAPK150.71669489
81ZAP700.70911719
82GRK60.70906767
83TXK0.69970364
84TYK20.68553054
85MARK20.63816335
86TLK10.63657954
87PIM10.63503337
88MAP3K70.58518637
89CAMKK10.58312876
90PLK10.57338704
91MOS0.56908532
92CLK10.55735273
93MATK0.55363791
94PLK40.55329861
95CSF1R0.54216668
96BRSK10.53233907
97MAPK110.53178610
98PAK10.53092192
99CHUK0.52627467
100PASK0.52439232
101IKBKB0.51830057
102MAP2K40.51755055
103GSK3A0.51531191
104CAMK10.51034953
105CCNB10.49437899
106BRD40.47224904
107MAP2K60.47135806
108CDK30.46270081
109PRKAA20.45980023
110PAK20.45887829
111RPS6KC10.45632620
112RPS6KL10.45632620
113RPS6KA60.45222721
114CSNK2A20.44732664
115MAPK70.44612566
116STK100.43170176
117LCK0.42351683
118CAMK40.42235619
119HCK0.42179544
120NEK10.41913351
121MAP2K20.41576356
122TGFBR10.40470776
123IRAK20.39957250
124JAK20.39597201
125RPS6KA50.39014120
126BMPR20.38836024
127TAF10.38767008
128RPS6KA40.38298746
129AURKA0.38205421
130CSNK2A10.37262924
131PRKCQ0.36635648
132TAOK10.36367758
133YES10.34743803
134CHEK20.33374427
135RPS6KB10.33049893
136MAP3K50.31788416
137TAOK20.31601638
138MAPKAPK50.31217462
139PIK3CG0.30643718
140TBK10.29959714
141CHEK10.29591647

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.73912917
2Ribosome_Homo sapiens_hsa030104.08289452
3Mismatch repair_Homo sapiens_hsa034303.68242015
4Protein export_Homo sapiens_hsa030603.15933652
5N-Glycan biosynthesis_Homo sapiens_hsa005102.81874161
6Base excision repair_Homo sapiens_hsa034102.80102291
7Homologous recombination_Homo sapiens_hsa034402.77371364
8Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.72034830
9Pentose phosphate pathway_Homo sapiens_hsa000302.51742137
10Proteasome_Homo sapiens_hsa030502.44250209
11Spliceosome_Homo sapiens_hsa030402.19234750
12Nucleotide excision repair_Homo sapiens_hsa034202.13497820
13Pyrimidine metabolism_Homo sapiens_hsa002401.99943498
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.96957802
15One carbon pool by folate_Homo sapiens_hsa006701.82940177
16Other glycan degradation_Homo sapiens_hsa005111.81816172
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.80593452
18Fanconi anemia pathway_Homo sapiens_hsa034601.69445663
19Non-homologous end-joining_Homo sapiens_hsa034501.59308159
20RNA polymerase_Homo sapiens_hsa030201.56184863
21Malaria_Homo sapiens_hsa051441.50360303
22Cell cycle_Homo sapiens_hsa041101.49191174
23RNA transport_Homo sapiens_hsa030131.48376964
24Non-small cell lung cancer_Homo sapiens_hsa052231.44720270
25Galactose metabolism_Homo sapiens_hsa000521.37812873
26Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.36816965
27Sulfur relay system_Homo sapiens_hsa041221.35938466
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.32604394
29Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.31488906
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.28617754
31Antigen processing and presentation_Homo sapiens_hsa046121.25715026
32Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.24589126
33Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.23867067
34Glutathione metabolism_Homo sapiens_hsa004801.23014245
35Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.20706206
36RNA degradation_Homo sapiens_hsa030181.17452286
37Purine metabolism_Homo sapiens_hsa002301.13748531
38Leishmaniasis_Homo sapiens_hsa051401.13492953
39* Renin-angiotensin system_Homo sapiens_hsa046141.13275010
40Platelet activation_Homo sapiens_hsa046111.10379687
41Biosynthesis of amino acids_Homo sapiens_hsa012301.09419431
42Staphylococcus aureus infection_Homo sapiens_hsa051501.07805639
43African trypanosomiasis_Homo sapiens_hsa051431.01098565
44Carbon metabolism_Homo sapiens_hsa012000.99587847
45Hematopoietic cell lineage_Homo sapiens_hsa046400.98801117
46Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.96947885
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87984884
48Drug metabolism - other enzymes_Homo sapiens_hsa009830.87898839
49Glycerophospholipid metabolism_Homo sapiens_hsa005640.86244269
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.83939953
51Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.83003945
52Starch and sucrose metabolism_Homo sapiens_hsa005000.82834429
53Chronic myeloid leukemia_Homo sapiens_hsa052200.82266197
54Influenza A_Homo sapiens_hsa051640.82081421
55Pancreatic cancer_Homo sapiens_hsa052120.81044549
56Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.79184831
57Herpes simplex infection_Homo sapiens_hsa051680.78982241
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78634602
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.76548630
60Asthma_Homo sapiens_hsa053100.74724897
61Phagosome_Homo sapiens_hsa041450.72983273
62Legionellosis_Homo sapiens_hsa051340.72972357
63Nitrogen metabolism_Homo sapiens_hsa009100.72764354
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72245305
65Thyroid cancer_Homo sapiens_hsa052160.72138379
66* Systemic lupus erythematosus_Homo sapiens_hsa053220.71633833
67Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.68300879
68Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.68102382
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.68023190
70Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.67552773
71Primary immunodeficiency_Homo sapiens_hsa053400.67474081
72Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65776093
73Folate biosynthesis_Homo sapiens_hsa007900.65168828
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63981163
75SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62839579
76Regulation of autophagy_Homo sapiens_hsa041400.62718826
77Parkinsons disease_Homo sapiens_hsa050120.61898334
78Alcoholism_Homo sapiens_hsa050340.61456073
79Basal transcription factors_Homo sapiens_hsa030220.60713013
80Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.60628847
81Cyanoamino acid metabolism_Homo sapiens_hsa004600.59965165
82Fructose and mannose metabolism_Homo sapiens_hsa000510.59370288
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.58353476
84p53 signaling pathway_Homo sapiens_hsa041150.58027834
85T cell receptor signaling pathway_Homo sapiens_hsa046600.55594799
86Oxidative phosphorylation_Homo sapiens_hsa001900.53547159
87Longevity regulating pathway - mammal_Homo sapiens_hsa042110.52723033
88Pertussis_Homo sapiens_hsa051330.52087894
89Epstein-Barr virus infection_Homo sapiens_hsa051690.51962126
90Selenocompound metabolism_Homo sapiens_hsa004500.51175013
91Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50238484
92mRNA surveillance pathway_Homo sapiens_hsa030150.48837599
93VEGF signaling pathway_Homo sapiens_hsa043700.48446282
94Choline metabolism in cancer_Homo sapiens_hsa052310.48252676
95Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.46612025
96Apoptosis_Homo sapiens_hsa042100.45985015
97Osteoclast differentiation_Homo sapiens_hsa043800.45883107
98Ether lipid metabolism_Homo sapiens_hsa005650.44474369
99Lysine degradation_Homo sapiens_hsa003100.44387077
100Sulfur metabolism_Homo sapiens_hsa009200.44146905
101Metabolic pathways_Homo sapiens_hsa011000.43278544
102Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42493123
103FoxO signaling pathway_Homo sapiens_hsa040680.41855211
104Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41722741
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.41616764
106Jak-STAT signaling pathway_Homo sapiens_hsa046300.40475985
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.40236733
108Acute myeloid leukemia_Homo sapiens_hsa052210.39230779
109* Amoebiasis_Homo sapiens_hsa051460.38995910
110Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38988368
111* Lysosome_Homo sapiens_hsa041420.38836794
112Renal cell carcinoma_Homo sapiens_hsa052110.38797276
113B cell receptor signaling pathway_Homo sapiens_hsa046620.37685090
114Measles_Homo sapiens_hsa051620.37677138
115Huntingtons disease_Homo sapiens_hsa050160.37512416
116Shigellosis_Homo sapiens_hsa051310.36320568
117Glycerolipid metabolism_Homo sapiens_hsa005610.35809475
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35101154
119Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.34969471
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.34899528
121Intestinal immune network for IgA production_Homo sapiens_hsa046720.34086340
122Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33290317
123Rheumatoid arthritis_Homo sapiens_hsa053230.33015561
124Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32382498
125Alzheimers disease_Homo sapiens_hsa050100.31905619
126HIF-1 signaling pathway_Homo sapiens_hsa040660.31701811
127Peroxisome_Homo sapiens_hsa041460.31325865
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.31195020
129Pancreatic secretion_Homo sapiens_hsa049720.31180506
130Glioma_Homo sapiens_hsa052140.31091120
131Hepatitis B_Homo sapiens_hsa051610.30786576
132Tuberculosis_Homo sapiens_hsa051520.30146401
133Viral carcinogenesis_Homo sapiens_hsa052030.29270649
134Central carbon metabolism in cancer_Homo sapiens_hsa052300.28983298
135Salmonella infection_Homo sapiens_hsa051320.28810203
136Leukocyte transendothelial migration_Homo sapiens_hsa046700.27267727
137NF-kappa B signaling pathway_Homo sapiens_hsa040640.27040794
138beta-Alanine metabolism_Homo sapiens_hsa004100.26401601
139Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25603480

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »