CTSH

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysosomal cysteine proteinase important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Alternate splicing of this gene results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1immunoglobulin mediated immune response (GO:0016064)4.50946794
2positive regulation of gamma-delta T cell activation (GO:0046645)4.43788919
3aromatic amino acid family catabolic process (GO:0009074)4.28332751
4tryptophan catabolic process (GO:0006569)4.27545962
5indole-containing compound catabolic process (GO:0042436)4.27545962
6indolalkylamine catabolic process (GO:0046218)4.27545962
7erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.23106348
8L-phenylalanine catabolic process (GO:0006559)4.23106348
9complement activation, alternative pathway (GO:0006957)4.21130683
10triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.20561402
11protein carboxylation (GO:0018214)4.18928343
12peptidyl-glutamic acid carboxylation (GO:0017187)4.18928343
13response to peptidoglycan (GO:0032494)4.16406682
14urea cycle (GO:0000050)4.02175308
15urea metabolic process (GO:0019627)4.02175308
16L-phenylalanine metabolic process (GO:0006558)4.01937429
17erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.01937429
18tryptophan metabolic process (GO:0006568)3.99564559
19negative regulation of interleukin-12 production (GO:0032695)3.97850268
20kynurenine metabolic process (GO:0070189)3.90208069
21detection of other organism (GO:0098543)3.86917355
22macrophage activation involved in immune response (GO:0002281)3.82304520
23interferon-gamma-mediated signaling pathway (GO:0060333)3.80571815
24detection of bacterium (GO:0016045)3.79528757
25high-density lipoprotein particle remodeling (GO:0034375)3.69989571
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.69559044
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.68563520
28negative regulation of cell killing (GO:0031342)3.68563520
29nitrogen cycle metabolic process (GO:0071941)3.68143688
30T-helper 1 type immune response (GO:0042088)3.65554881
31regulation of protein activation cascade (GO:2000257)3.64363793
32glycosphingolipid catabolic process (GO:0046479)3.62467930
33bile acid biosynthetic process (GO:0006699)3.61800940
34phospholipid efflux (GO:0033700)3.58443913
35alpha-linolenic acid metabolic process (GO:0036109)3.57531258
36regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.57071474
37cysteine metabolic process (GO:0006534)3.55625407
38myeloid dendritic cell differentiation (GO:0043011)3.54030474
39regulation of antigen processing and presentation (GO:0002577)3.51887190
40glyoxylate metabolic process (GO:0046487)3.50810408
41regulation of complement activation (GO:0030449)3.49914919
42reverse cholesterol transport (GO:0043691)3.49230528
43plasma lipoprotein particle clearance (GO:0034381)3.48200372
44cholesterol efflux (GO:0033344)3.46251193
45regulation of cholesterol esterification (GO:0010872)3.43147888
46B cell mediated immunity (GO:0019724)3.41794934
47negative regulation of fibrinolysis (GO:0051918)3.41645658
48neutrophil activation involved in immune response (GO:0002283)3.41598437
49* surfactant homeostasis (GO:0043129)3.37924112
50regulation of triglyceride catabolic process (GO:0010896)3.35386336
51detection of external biotic stimulus (GO:0098581)3.34801719
52antigen processing and presentation of endogenous antigen (GO:0019883)3.33649919
53regulation of gamma-delta T cell activation (GO:0046643)3.33649496
54oligosaccharide catabolic process (GO:0009313)3.33382538
55sulfur amino acid catabolic process (GO:0000098)3.30869124
56glycolipid catabolic process (GO:0019377)3.28958902
57lipopolysaccharide-mediated signaling pathway (GO:0031663)3.28692994
58regulation of macrophage chemotaxis (GO:0010758)3.27138028
59NIK/NF-kappaB signaling (GO:0038061)3.25633455
60myeloid dendritic cell activation (GO:0001773)3.25396029
61protein-lipid complex remodeling (GO:0034368)3.20455239
62macromolecular complex remodeling (GO:0034367)3.20455239
63plasma lipoprotein particle remodeling (GO:0034369)3.20455239
64regulation of fibrinolysis (GO:0051917)3.19734505
65antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.19251171
66aldehyde catabolic process (GO:0046185)3.18687948
67germinal center formation (GO:0002467)3.17023956
68complement activation (GO:0006956)3.13880814
69regulation of B cell receptor signaling pathway (GO:0050855)3.13726791
70amino sugar catabolic process (GO:0046348)3.10793632
71regulation of dendritic cell antigen processing and presentation (GO:0002604)3.10098139
72detection of molecule of bacterial origin (GO:0032490)3.09422926
73homocysteine metabolic process (GO:0050667)3.09130735
74cellular extravasation (GO:0045123)3.08880541
75positive regulation of type 2 immune response (GO:0002830)3.08589856
76regulation of mononuclear cell migration (GO:0071675)3.07941008
77positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.07107606
78type I interferon signaling pathway (GO:0060337)3.06874601
79cellular response to type I interferon (GO:0071357)3.06874601
80bile acid metabolic process (GO:0008206)3.05148121
81regulation of mast cell degranulation (GO:0043304)3.05063490
82response to type I interferon (GO:0034340)3.04989325
83complement activation, classical pathway (GO:0006958)3.04358273
84negative regulation of cholesterol transport (GO:0032375)3.02800728
85negative regulation of sterol transport (GO:0032372)3.02800728
86positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.01957450
87cellular response to interferon-gamma (GO:0071346)3.00746640
88aromatic amino acid family metabolic process (GO:0009072)3.00245510
89phospholipid homeostasis (GO:0055091)2.97925250
90low-density lipoprotein particle remodeling (GO:0034374)2.97425681
91positive regulation of triglyceride lipase activity (GO:0061365)2.96011470
92positive regulation of lipoprotein lipase activity (GO:0051006)2.96011470
93cellular biogenic amine catabolic process (GO:0042402)2.95896411
94amine catabolic process (GO:0009310)2.95896411
95fibrinolysis (GO:0042730)2.95846336
96positive regulation of cellular amide metabolic process (GO:0034250)2.95609912
97positive regulation of antigen processing and presentation (GO:0002579)2.95584027
98negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.95230795
99regulation of interleukin-2 biosynthetic process (GO:0045076)2.93374668
100protein activation cascade (GO:0072376)2.93219896
101indolalkylamine metabolic process (GO:0006586)2.91379156
102regulation of tolerance induction (GO:0002643)2.89595258
103detection of biotic stimulus (GO:0009595)2.88700336
104amino-acid betaine metabolic process (GO:0006577)2.88383083
105imidazole-containing compound metabolic process (GO:0052803)2.87530322
106positive regulation of mast cell activation (GO:0033005)2.86430156
107response to muramyl dipeptide (GO:0032495)2.85231789
108regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84401779
109B cell receptor signaling pathway (GO:0050853)2.84034731
110positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.83783586
111tyrosine metabolic process (GO:0006570)2.82757767
112acylglycerol homeostasis (GO:0055090)2.82520417
113triglyceride homeostasis (GO:0070328)2.82520417
114modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.82136810
115positive regulation by organism of defense response of other organism involved in symbiotic interact2.82136810
116modulation by symbiont of host immune response (GO:0052553)2.82136810
117positive regulation by symbiont of host defense response (GO:0052509)2.82136810
118modulation by symbiont of host defense response (GO:0052031)2.82136810
119modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.82136810
120pinocytosis (GO:0006907)2.81962245
121response to interferon-gamma (GO:0034341)2.81035108
122ceramide catabolic process (GO:0046514)2.80921694
123acute-phase response (GO:0006953)2.80216042
124plasma lipoprotein particle assembly (GO:0034377)2.79482678
125positive regulation of blood coagulation (GO:0030194)2.78949656
126positive regulation of hemostasis (GO:1900048)2.78949656
127respiratory burst (GO:0045730)2.78921718
128regulation of leukocyte degranulation (GO:0043300)2.78545329
129hydrogen peroxide biosynthetic process (GO:0050665)2.77870450
130regulation of T cell tolerance induction (GO:0002664)2.77805203
131defense response to protozoan (GO:0042832)2.77400485
132regulation of myeloid leukocyte mediated immunity (GO:0002886)2.76858107
133positive regulation of lipid catabolic process (GO:0050996)2.75305198
134negative regulation of erythrocyte differentiation (GO:0045647)2.74781340
135benzene-containing compound metabolic process (GO:0042537)2.74727588
136dendritic cell differentiation (GO:0097028)2.74286719
137positive regulation of coagulation (GO:0050820)2.73275761
138regulation of mast cell activation involved in immune response (GO:0033006)2.72862080
139negative regulation of myeloid cell apoptotic process (GO:0033033)2.72764292
140positive regulation of interferon-alpha production (GO:0032727)2.72726107
141regulation of T-helper 1 cell differentiation (GO:0045625)2.72156970
142regulation of interferon-beta biosynthetic process (GO:0045357)2.72070808
143regulation of superoxide anion generation (GO:0032928)2.71802353
144cellular glucuronidation (GO:0052695)2.70491361
145cholesterol homeostasis (GO:0042632)2.70334251
146positive regulation of mast cell activation involved in immune response (GO:0033008)2.70331146
147positive regulation of mast cell degranulation (GO:0043306)2.70331146
148bile acid and bile salt transport (GO:0015721)2.70145619
149regulation of T-helper 2 cell differentiation (GO:0045628)2.70076792
150regulation of cholesterol storage (GO:0010885)2.69895678
151sterol homeostasis (GO:0055092)2.69579943
152regulation of gamma-delta T cell differentiation (GO:0045586)2.69440271
153response to protozoan (GO:0001562)2.69111325
154positive regulation of leukocyte degranulation (GO:0043302)2.68706831
155serine family amino acid catabolic process (GO:0009071)2.68536443
156N-acetylneuraminate metabolic process (GO:0006054)2.68479349
157regulation of podosome assembly (GO:0071801)2.68215950
158low-density lipoprotein particle clearance (GO:0034383)2.68165108
159urate metabolic process (GO:0046415)2.67820903
160myeloid cell activation involved in immune response (GO:0002275)2.67727636
161positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.67285181
162lipoprotein metabolic process (GO:0042157)2.66786873
163protein-lipid complex assembly (GO:0065005)2.65252852
164positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.65191786
165regulation of hypersensitivity (GO:0002883)2.65017197
166macrophage activation (GO:0042116)2.64695772
167positive regulation of B cell differentiation (GO:0045579)2.64351655
168lysine catabolic process (GO:0006554)2.64332426
169lysine metabolic process (GO:0006553)2.64332426
170antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.63947722
171antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.63947722
172plasma lipoprotein particle organization (GO:0071827)2.63692554
173cholesterol transport (GO:0030301)2.63233302
174sterol transport (GO:0015918)2.63233302
175response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.62470357
176response to host immune response (GO:0052572)2.62470357
177production of molecular mediator involved in inflammatory response (GO:0002532)2.60556242
178T cell costimulation (GO:0031295)2.60367976
179* cellular response to thyroid hormone stimulus (GO:0097067)2.59450288
180granulocyte activation (GO:0036230)2.57815005
181reactive oxygen species biosynthetic process (GO:1903409)2.56453291
182lymphocyte costimulation (GO:0031294)2.55878150

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.52465274
2IRF8_22096565_ChIP-ChIP_GC-B_Human4.89910238
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.87754612
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.29421145
5EGR1_23403033_ChIP-Seq_LIVER_Mouse4.14547711
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.05803003
7IRF8_21731497_ChIP-ChIP_J774_Mouse3.95195745
8BP1_19119308_ChIP-ChIP_Hs578T_Human3.35784026
9PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.07783120
10* IRF8_27001747_Chip-Seq_BMDM_Mouse2.98853190
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.87477573
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.77767613
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.69338428
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.67140488
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.66512048
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.63929820
17GATA1_22025678_ChIP-Seq_K562_Human2.35824266
18VDR_21846776_ChIP-Seq_THP-1_Human2.33743152
19IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.32543596
20NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.31148689
21NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30453486
22* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.24118550
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.09488254
24TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.08224848
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.02664570
26CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.00439518
27THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.93096066
28STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.89721362
29LXR_22292898_ChIP-Seq_THP-1_Human1.88524326
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.84485264
31MYC_22102868_ChIP-Seq_BL_Human1.84049839
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.77372628
33VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.74172959
34KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73191374
35RARG_19884340_ChIP-ChIP_MEFs_Mouse1.71863057
36STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.66717785
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.65572940
38MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.61946302
39CLOCK_20551151_ChIP-Seq_293T_Human1.59790911
40STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.53969836
41ELK3_25401928_ChIP-Seq_HUVEC_Human1.49328557
42TCF7_22412390_ChIP-Seq_EML_Mouse1.49119656
43ESR1_21235772_ChIP-Seq_MCF-7_Human1.46539969
44GATA2_21666600_ChIP-Seq_HMVEC_Human1.44434929
45BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40948931
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.39636733
47EGR1_19374776_ChIP-ChIP_THP-1_Human1.37214413
48VDR_24787735_ChIP-Seq_THP-1_Human1.35597686
49HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34815115
50PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34738281
51UTX_26944678_Chip-Seq_JUKART_Human1.34037189
52MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.32869973
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.30710510
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.29576998
55TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.27668693
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.27353618
57STAT4_19710469_ChIP-ChIP_TH1__Mouse1.25117890
58GATA1_19941826_ChIP-Seq_K562_Human1.24518961
59TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24478928
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.23779876
61* SOX2_20726797_ChIP-Seq_SW620_Human1.22261337
62PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.22175264
63SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.21989345
64RACK7_27058665_Chip-Seq_MCF-7_Human1.20200062
65TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.19658871
66KDM2B_26808549_Chip-Seq_DND41_Human1.19349244
67GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18361628
68LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.17863227
69MAF_26560356_Chip-Seq_TH2_Human1.17765042
70TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17704113
71SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16378848
72* GATA4_25053715_ChIP-Seq_YYC3_Human1.15903132
73CDX2_20551321_ChIP-Seq_CACO-2_Human1.14423493
74* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.14243196
75CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12881341
76* FOXA2_19822575_ChIP-Seq_HepG2_Human1.12128760
77FOXO3_23340844_ChIP-Seq_DLD1_Human1.11724343
78GATA2_22383799_ChIP-Seq_G1ME_Mouse1.11637745
79NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.11442027
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08952525
81RUNX_20019798_ChIP-Seq_JUKART_Human1.08605584
82KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07220192
83SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07090691
84* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05545943
85NRF2_20460467_ChIP-Seq_MEFs_Mouse1.05480810
86NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.05480810
87PPAR_26484153_Chip-Seq_NCI-H1993_Human1.05319323
88BCOR_27268052_Chip-Seq_Bcells_Human1.05306648
89TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04884227
90EGR1_19032775_ChIP-ChIP_M12_Human1.04516971
91SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.02957250
92* GATA3_27048872_Chip-Seq_THYMUS_Human1.02867004
93CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.02335191
94BCL6_27268052_Chip-Seq_Bcells_Human1.01818686
95STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01060479
96PU_27001747_Chip-Seq_BMDM_Mouse1.00266176
97TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.99396790
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.98267443
99PU.1_20513432_ChIP-Seq_Bcells_Mouse0.98202489
100KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97588044
101VDR_24763502_ChIP-Seq_THP-1_Human0.94709262
102MAF_26560356_Chip-Seq_TH1_Human0.94340908
103NCOR1_26117541_ChIP-Seq_K562_Human0.94329514
104FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.93824914
105FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93450745
106CJUN_26792858_Chip-Seq_BT549_Human0.92592450
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.91647448
108SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.90089397
109RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89597899
110ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.89425858
111GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.88512105
112E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.85493209
113SCL_19346495_ChIP-Seq_HPC-7_Human0.85381952
114CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.85206775
115MYB_26560356_Chip-Seq_TH2_Human0.84832155
116BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.84808308
117GATA2_19941826_ChIP-Seq_K562_Human0.84668306
118SPI1_23127762_ChIP-Seq_K562_Human0.83732908
119CDX2_19796622_ChIP-Seq_MESCs_Mouse0.82504481
120CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.82180924
121SPI1_23547873_ChIP-Seq_NB4_Human0.82124089
122P63_26484246_Chip-Seq_KERATINOCYTES_Human0.81954953
123FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.81082524
124* HNF4A_19822575_ChIP-Seq_HepG2_Human0.80359910
125SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.79975022
126SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.79975022
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.79962878
128JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.77960373
129RUNX1_22412390_ChIP-Seq_EML_Mouse0.77000421
130JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76858429
131GATA3_26560356_Chip-Seq_TH2_Human0.76433652
132MYB_26560356_Chip-Seq_TH1_Human0.76398608
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75299018
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.75002819
135GATA1_19941827_ChIP-Seq_MEL_Mouse0.73332443
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.72830797

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.59234755
2MP0005360_urolithiasis4.25950711
3MP0005085_abnormal_gallbladder_physiolo3.62543140
4MP0001835_abnormal_antigen_presentation3.27464048
5MP0002138_abnormal_hepatobiliary_system3.26738722
6MP0005365_abnormal_bile_salt3.10507589
7MP0003191_abnormal_cellular_cholesterol2.99283174
8MP0004782_abnormal_surfactant_physiolog2.86808427
9MP0008875_abnormal_xenobiotic_pharmacok2.86633147
10MP0009840_abnormal_foam_cell2.80470408
11MP0003436_decreased_susceptibility_to2.47539948
12MP0003252_abnormal_bile_duct2.43756858
13MP0005083_abnormal_biliary_tract2.42932614
14MP0002254_reproductive_system_inflammat2.24708397
15MP0000685_abnormal_immune_system2.24366233
16MP0005058_abnormal_lysosome_morphology2.17747385
17MP0010329_abnormal_lipoprotein_level2.14454005
18MP0009785_altered_susceptibility_to2.02734349
19MP0005387_immune_system_phenotype2.01980409
20MP0001790_abnormal_immune_system2.01980409
21MP0002148_abnormal_hypersensitivity_rea2.01889984
22MP0003724_increased_susceptibility_to1.94692095
23MP0002419_abnormal_innate_immunity1.92634484
24MP0005025_abnormal_response_to1.78250239
25MP0009764_decreased_sensitivity_to1.76016540
26MP0005332_abnormal_amino_acid1.74887134
27MP0006082_CNS_inflammation1.69241844
28MP0004019_abnormal_vitamin_homeostasis1.67159213
29MP0003195_calcinosis1.63911062
30MP0003806_abnormal_nucleotide_metabolis1.63669017
31MP0005000_abnormal_immune_tolerance1.61886482
32MP0000609_abnormal_liver_physiology1.59219066
33MP0001666_abnormal_nutrient_absorption1.56056072
34MP0003303_peritoneal_inflammation1.55508052
35MP0008469_abnormal_protein_level1.51562084
36MP0001800_abnormal_humoral_immune1.51006511
37MP0004510_myositis1.49611933
38MP0002452_abnormal_antigen_presenting1.49006586
39MP0009333_abnormal_splenocyte_physiolog1.45880457
40MP0001853_heart_inflammation1.43682581
41MP0005464_abnormal_platelet_physiology1.43338710
42MP0001958_emphysema1.42647821
43MP0000858_altered_metastatic_potential1.41987018
44MP0002118_abnormal_lipid_homeostasis1.37406967
45MP0002723_abnormal_immune_serum1.36534174
46MP0003183_abnormal_peptide_metabolism1.36008204
47MP0001845_abnormal_inflammatory_respons1.35488071
48MP0009643_abnormal_urine_homeostasis1.32767768
49MP0001533_abnormal_skeleton_physiology1.29704963
50MP0005319_abnormal_enzyme/_coenzyme1.29644706
51MP0005671_abnormal_response_to1.26621395
52MP0008260_abnormal_autophagy1.26319052
53MP0009278_abnormal_bone_marrow1.26176418
54MP0002398_abnormal_bone_marrow1.21802408
55MP0002405_respiratory_system_inflammati1.21484508
56MP0005397_hematopoietic_system_phenotyp1.20406023
57MP0001545_abnormal_hematopoietic_system1.20406023
58MP0003186_abnormal_redox_activity1.20273560
59MP0004947_skin_inflammation1.18288556
60MP0003075_altered_response_to1.17889733
61MP0000604_amyloidosis1.17338869
62MP0003705_abnormal_hypodermis_morpholog1.17200110
63MP0003763_abnormal_thymus_physiology1.16363885
64MP0010155_abnormal_intestine_physiology1.15906278
65MP0010368_abnormal_lymphatic_system1.15796555
66MP0001819_abnormal_immune_cell1.14012374
67MP0005584_abnormal_enzyme/coenzyme_acti1.13926695
68MP0003300_gastrointestinal_ulcer1.13083592
69MP0002420_abnormal_adaptive_immunity1.12044037
70MP0000465_gastrointestinal_hemorrhage1.11174598
71MP0003828_pulmonary_edema1.10585346
72MP0005167_abnormal_blood-brain_barrier1.10319671
73MP0000689_abnormal_spleen_morphology1.10164839
74MP0004883_abnormal_blood_vessel1.09068860
75MP0002136_abnormal_kidney_physiology1.07676463
76MP0002166_altered_tumor_susceptibility1.05351734
77MP0000343_altered_response_to1.05085004
78MP0003091_abnormal_cell_migration1.03583447
79MP0009763_increased_sensitivity_to1.01996654
80MP0005166_decreased_susceptibility_to1.01803746
81MP0003866_abnormal_defecation0.99393228
82MP0002722_abnormal_immune_system0.98745600
83MP0003690_abnormal_glial_cell0.98699277
84MP0005164_abnormal_response_to0.97833374
85MP0003329_amyloid_beta_deposits0.97229502
86MP0000249_abnormal_blood_vessel0.96346455
87MP0001851_eye_inflammation0.95861590
88MP0002998_abnormal_bone_remodeling0.95170059
89MP0002876_abnormal_thyroid_physiology0.94437065
90MP0008004_abnormal_stomach_pH0.91964340
91MP0000598_abnormal_liver_morphology0.90136628
92MP0002132_abnormal_respiratory_system0.87510707
93MP0002295_abnormal_pulmonary_circulatio0.87329001
94MP0005310_abnormal_salivary_gland0.87202898
95MP0000920_abnormal_myelination0.87091212
96MP0003453_abnormal_keratinocyte_physiol0.84876307
97MP0005165_increased_susceptibility_to0.84591730
98MP0002006_tumorigenesis0.83479009
99MP0002933_joint_inflammation0.83191727
100MP0001873_stomach_inflammation0.82820242
101MP0005451_abnormal_body_composition0.82798373
102MP0001764_abnormal_homeostasis0.81531270
103MP0003172_abnormal_lysosome_physiology0.81267883
104MP0000716_abnormal_immune_system0.81154785
105MP0001756_abnormal_urination0.80684327
106MP0001879_abnormal_lymphatic_vessel0.80253268
107MP0003448_altered_tumor_morphology0.79440865
108MP0001881_abnormal_mammary_gland0.76901711
109MP0001663_abnormal_digestive_system0.76266669
110MP0002877_abnormal_melanocyte_morpholog0.75243949
111MP0003566_abnormal_cell_adhesion0.71990553
112MP0003795_abnormal_bone_structure0.71468564
113MP0009642_abnormal_blood_homeostasis0.71071961
114MP0003656_abnormal_erythrocyte_physiolo0.69633753
115MP0005647_abnormal_sex_gland0.69418137
116MP0005408_hypopigmentation0.68670355
117MP0001542_abnormal_bone_strength0.67399030
118MP0002133_abnormal_respiratory_system0.66129376
119MP0005388_respiratory_system_phenotype0.66129376
120MP0008438_abnormal_cutaneous_collagen0.65658784
121MP0003045_fibrosis0.65067374
122MP0010234_abnormal_vibrissa_follicle0.64943532
123MP0005390_skeleton_phenotype0.63605560
124MP0008874_decreased_physiological_sensi0.63402965
125MP0005023_abnormal_wound_healing0.63099159
126MP0002277_abnormal_respiratory_mucosa0.62949634
127MP0000767_abnormal_smooth_muscle0.62838152
128MP0005084_abnormal_gallbladder_morpholo0.62578985
129MP0002429_abnormal_blood_cell0.61794195

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)5.59024619
2Abnormality of liposaccharide metabolism (HP:0010968)5.59024619
3Abnormality of glycosphingolipid metabolism (HP:0004343)5.59024619
4Systemic lupus erythematosus (HP:0002725)5.10384801
5Complement deficiency (HP:0004431)5.01376436
6Recurrent gram-negative bacterial infections (HP:0005420)4.88972668
7Deep venous thrombosis (HP:0002625)4.67677660
8Recurrent bacterial skin infections (HP:0005406)4.48554128
9Interstitial pulmonary disease (HP:0006530)4.34317539
10Eczematoid dermatitis (HP:0000976)4.33963729
11Recurrent abscess formation (HP:0002722)4.23640405
12Joint hemorrhage (HP:0005261)4.20332441
13Abnormality of monocarboxylic acid metabolism (HP:0010996)4.19859390
14Glomerulonephritis (HP:0000099)4.08741713
15Intrahepatic cholestasis (HP:0001406)4.08495317
16Abnormality of complement system (HP:0005339)4.05766800
17Xanthomatosis (HP:0000991)4.03156780
18Prolonged partial thromboplastin time (HP:0003645)3.98741708
19Abnormality of aromatic amino acid family metabolism (HP:0004338)3.98119067
20Loss of speech (HP:0002371)3.48910072
21Myocardial infarction (HP:0001658)3.46715909
22Abnormality of glutamine family amino acid metabolism (HP:0010902)3.40260961
23Abnormality of macrophages (HP:0004311)3.34434352
24Abnormality of the common coagulation pathway (HP:0010990)3.29389793
25Gastrointestinal stroma tumor (HP:0100723)3.22858168
26Nephritis (HP:0000123)3.11941634
27Hyperlipoproteinemia (HP:0010980)3.07002577
28Recurrent sinusitis (HP:0011108)3.02093500
29Recurrent skin infections (HP:0001581)3.00889284
30Chronic obstructive pulmonary disease (HP:0006510)3.00361832
31Obstructive lung disease (HP:0006536)3.00361832
32Hypobetalipoproteinemia (HP:0003563)2.99464719
33Purpura (HP:0000979)2.96063344
34Meningitis (HP:0001287)2.91227605
35Vacuolated lymphocytes (HP:0001922)2.89531391
36Autoimmune thrombocytopenia (HP:0001973)2.88209172
37Esophageal varix (HP:0002040)2.87249258
38Disinhibition (HP:0000734)2.86047880
39Gout (HP:0001997)2.74099853
40Pulmonary infiltrates (HP:0002113)2.68879731
41Neurofibrillary tangles (HP:0002185)2.68066720
42Epidermoid cyst (HP:0200040)2.66995782
43Axonal loss (HP:0003447)2.64793623
44Abnormality of the nasal mucosa (HP:0000433)2.64647437
45Cellulitis (HP:0100658)2.61703395
46Malnutrition (HP:0004395)2.58991606
47Abnormality of pyrimidine metabolism (HP:0004353)2.58457431
48Pustule (HP:0200039)2.57824117
49Restrictive lung disease (HP:0002091)2.56796847
50Hyperammonemia (HP:0001987)2.56532279
51Recurrent viral infections (HP:0004429)2.56529872
52Fat malabsorption (HP:0002630)2.56503929
53Abnormality of nucleobase metabolism (HP:0010932)2.55457490
54Amyloidosis (HP:0011034)2.55256360
55Hypoalphalipoproteinemia (HP:0003233)2.54779536
56Vascular calcification (HP:0004934)2.54071643
57Abnormality of purine metabolism (HP:0004352)2.53957520
58Hypolipoproteinemia (HP:0010981)2.53024618
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.52227984
60Recurrent cutaneous fungal infections (HP:0011370)2.51738058
61Chronic mucocutaneous candidiasis (HP:0002728)2.51738058
62Gingival bleeding (HP:0000225)2.50478143
63Tubulointerstitial fibrosis (HP:0005576)2.47100165
64Gingivitis (HP:0000230)2.45439560
65Abnormality of aspartate family amino acid metabolism (HP:0010899)2.45395865
66Hypercholesterolemia (HP:0003124)2.41366489
67Nasal polyposis (HP:0100582)2.41317593
68Hematochezia (HP:0002573)2.40293387
69Abnormality of the intrinsic pathway (HP:0010989)2.40277696
70Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.38414971
71Colitis (HP:0002583)2.36551289
72Abnormality of proline metabolism (HP:0010907)2.36430786
73Hydroxyprolinuria (HP:0003080)2.36430786
74Increased serum ferritin (HP:0003281)2.35741968
75Hemoptysis (HP:0002105)2.35576279
76Orchitis (HP:0100796)2.35248582
77Recurrent bronchitis (HP:0002837)2.32563917
78Hyperglycinuria (HP:0003108)2.31764807
79Mediastinal lymphadenopathy (HP:0100721)2.29869852
80Hepatocellular carcinoma (HP:0001402)2.29468880
81Cardiovascular calcification (HP:0011915)2.28568130
82Osteomyelitis (HP:0002754)2.28558590
83Polycythemia (HP:0001901)2.28488505
84Recurrent fungal infections (HP:0002841)2.28288753
85Increased IgE level (HP:0003212)2.27929961
86Spontaneous hematomas (HP:0007420)2.27640487
87Periodontitis (HP:0000704)2.26152154
88Abnormality of methionine metabolism (HP:0010901)2.25168656
89Abnormality of fatty-acid metabolism (HP:0004359)2.24512046
90Agammaglobulinemia (HP:0004432)2.24473886
91Myositis (HP:0100614)2.23066412
92Mitral stenosis (HP:0001718)2.16999190
93Neuronal loss in central nervous system (HP:0002529)2.16411475
94Gastrointestinal infarctions (HP:0005244)2.15361637
95Premature loss of primary teeth (HP:0006323)2.15190969
96Mutism (HP:0002300)2.14015571
97Emphysema (HP:0002097)2.13592534
98Osteolytic defects of the phalanges of the hand (HP:0009771)2.13494168
99Osteolytic defects of the hand bones (HP:0009699)2.13494168
100Recurrent pneumonia (HP:0006532)2.13477399
101Dysostosis multiplex (HP:0000943)2.13422075
102Hepatosplenomegaly (HP:0001433)2.12953313
103Steatorrhea (HP:0002570)2.12836110
104Thick nail (HP:0001805)2.11361180
105Elevated erythrocyte sedimentation rate (HP:0003565)2.10874106
106Inflammation of the large intestine (HP:0002037)2.10426454
107Thrombophlebitis (HP:0004418)2.10314272
108Hemorrhage of the eye (HP:0011885)2.09405175
109Ketosis (HP:0001946)2.06597192
110Respiratory distress (HP:0002098)2.05423247
111Chronic diarrhea (HP:0002028)2.03474472
112Hypergammaglobulinemia (HP:0010702)2.02957772
113Keratoconjunctivitis sicca (HP:0001097)2.02541940
114Abnormality of glycine metabolism (HP:0010895)2.02141628
115Abnormality of serine family amino acid metabolism (HP:0010894)2.02141628
116Urticaria (HP:0001025)2.01903298
117Gastrointestinal inflammation (HP:0004386)2.01686578
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00646544
119Vasculitis (HP:0002633)2.00433215
120Increased cerebral lipofuscin (HP:0011813)2.00216225
121Mucopolysacchariduria (HP:0008155)1.99432166
122Urinary glycosaminoglycan excretion (HP:0003541)1.99432166
123Chronic otitis media (HP:0000389)1.97708973
124Delayed CNS myelination (HP:0002188)1.97267550
125Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.96342095
126Pulmonary embolism (HP:0002204)1.96117350
127Peritonitis (HP:0002586)1.95813916
128Increased IgM level (HP:0003496)1.95801740
129Prolonged neonatal jaundice (HP:0006579)1.95442990
130Stomatitis (HP:0010280)1.95228287
131Abnormality of the vasculature of the conjunctiva (HP:0008054)1.95069797
132Conjugated hyperbilirubinemia (HP:0002908)1.94189707
133Abnormal delayed hypersensitivity skin test (HP:0002963)1.93970368
134Abnormality of iron homeostasis (HP:0011031)1.93887476
135Hyperglycinemia (HP:0002154)1.93643871
136Hypoglycemic coma (HP:0001325)1.93547905
137Cerebral inclusion bodies (HP:0100314)1.92604254
138Abnormality of transition element cation homeostasis (HP:0011030)1.92199003
139Retrobulbar optic neuritis (HP:0100654)1.92081376
140Optic neuritis (HP:0100653)1.92081376
141Progressive neurologic deterioration (HP:0002344)1.91915564
142Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.91164370
143Gangrene (HP:0100758)1.89964803
144Abnormality of the periventricular white matter (HP:0002518)1.89425307
145Petechiae (HP:0000967)1.88966006
146Menorrhagia (HP:0000132)1.87755386
147Increased neuronal autofluorescent lipopigment (HP:0002074)1.87628074
148Encephalitis (HP:0002383)1.87474174
149Recurrent lower respiratory tract infections (HP:0002783)1.86221781
150Arthralgia (HP:0002829)1.85775890
151Lymphopenia (HP:0001888)1.85530325
152Abnormality of polysaccharide metabolism (HP:0011012)1.84756048
153Abnormality of glycosaminoglycan metabolism (HP:0004371)1.84756048
154Abnormality of mucopolysaccharide metabolism (HP:0011020)1.84756048
155Asymmetric septal hypertrophy (HP:0001670)1.84059093
156Hypertensive crisis (HP:0100735)1.84058692
157Tetraparesis (HP:0002273)1.83626317
158T lymphocytopenia (HP:0005403)1.83369291

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.99366589
2TYK23.36062891
3ERN13.08942435
4TGFBR22.98763465
5BLK2.65821393
6PRPF4B2.63452565
7TBK12.61013081
8IRAK42.48717132
9IRAK32.48566415
10FGFR42.35810069
11IKBKE2.02309005
12JAK11.99793851
13IKBKB1.99207228
14NME21.97884566
15MAP4K11.96973474
16EPHB11.94444510
17TAOK31.92526322
18NEK91.92420576
19SIK11.70942430
20MAP3K31.67829689
21JAK31.67226845
22ZAP701.65720542
23CHUK1.63142837
24MST1R1.62127772
25MAP3K131.57835667
26KIT1.54399282
27RIPK41.51909980
28STK101.51505245
29CDC42BPA1.50610677
30BCKDK1.49905866
31CSF1R1.46637025
32CSK1.46299846
33PTK61.39580033
34MAP2K31.36377369
35LRRK21.32656212
36DDR21.32630985
37TRIB31.29529532
38JAK21.20009991
39TAOK21.19727514
40EPHA31.17404588
41SMG11.17165637
42FES1.14739981
43TIE11.13252692
44MAP3K11.10425863
45PDPK11.09254247
46BTK1.06888373
47EPHA21.04780895
48PIK3CG1.04271030
49GRK71.04042526
50TAOK11.02644162
51TEC0.99348202
52FGFR30.95795366
53PIM20.94398305
54SYK0.94382001
55ABL20.93821230
56FLT30.90828465
57FRK0.89510247
58MST40.88968531
59STK240.88581466
60PDK10.86952720
61RIPK10.86779627
62RPS6KA40.84465201
63PBK0.83930536
64PAK40.83588436
65CDK60.83250751
66CAMK1D0.80893673
67DAPK20.78220704
68KDR0.77204014
69MATK0.73851699
70LYN0.73564725
71TESK20.73560063
72KSR20.73283524
73MAP3K110.72755565
74MAPK150.72449309
75ARAF0.71490729
76GRK10.70461795
77ITK0.70450956
78PIM10.70064217
79HCK0.69224463
80BMX0.69153570
81PRKCQ0.68186363
82PRKAA20.67870318
83MAP3K20.67579660
84EGFR0.67262322
85MAPK120.65899851
86BMPR20.65134042
87SIK30.64672389
88INSRR0.61690386
89ABL10.61646715
90PRKCD0.60666929
91TNK20.60403877
92IRAK10.60171251
93MAPK110.59643262
94NUAK10.58886472
95GSK3A0.58460895
96FGFR20.56509839
97ERBB40.56264099
98MOS0.55760277
99ACVR1B0.55497394
100MAPK70.55092403
101MARK30.54093314
102MARK20.53895419
103PKN20.52856170
104GRK60.52497782
105SIK20.51343090
106EIF2AK20.51280847
107EPHB20.51089271
108STK30.50956578
109LCK0.50428347
110DYRK1B0.49637405
111IRAK20.48651632
112MET0.48618668
113EEF2K0.48449782
114RPS6KA20.48382017
115TRPM70.47965544
116CAMKK20.47014792
117FYN0.46510258
118ICK0.46472346
119IGF1R0.46067518
120PTK20.45809083
121PDGFRB0.45741170
122MAP3K80.45710491
123MAP2K60.44085276
124MAP2K20.43104925
125HIPK20.42839764
126MAPKAPK20.42407123
127MAPKAPK30.41485238
128YES10.41090448
129RPS6KC10.41024514
130RPS6KL10.41024514
131PDK20.39713920
132LATS10.38421736
133TXK0.38037200
134CAMKK10.37374286
135SGK30.36497324
136STK40.35045076
137FGR0.34739158
138MAPK40.34337932
139PRKCZ0.32663482

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.63485688
2Staphylococcus aureus infection_Homo sapiens_hsa051503.47288101
3Autoimmune thyroid disease_Homo sapiens_hsa053203.10147452
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.06531396
5Complement and coagulation cascades_Homo sapiens_hsa046103.03712009
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.86847076
7Type I diabetes mellitus_Homo sapiens_hsa049402.51750022
8Nitrogen metabolism_Homo sapiens_hsa009102.42498686
9Arginine biosynthesis_Homo sapiens_hsa002202.40603174
10Tryptophan metabolism_Homo sapiens_hsa003802.37234985
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.34642894
12Fatty acid degradation_Homo sapiens_hsa000711.97261645
13Histidine metabolism_Homo sapiens_hsa003401.95627545
14Viral myocarditis_Homo sapiens_hsa054161.93233248
15Caffeine metabolism_Homo sapiens_hsa002321.91925831
16Peroxisome_Homo sapiens_hsa041461.85338111
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.84354724
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76740034
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.72998780
20PPAR signaling pathway_Homo sapiens_hsa033201.68445293
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.66715732
22Chemical carcinogenesis_Homo sapiens_hsa052041.64551519
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.58025179
24Leishmaniasis_Homo sapiens_hsa051401.51023093
25beta-Alanine metabolism_Homo sapiens_hsa004101.45590392
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.42776233
27Phenylalanine metabolism_Homo sapiens_hsa003601.39502592
28Retinol metabolism_Homo sapiens_hsa008301.38950592
29Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.38476543
30Pertussis_Homo sapiens_hsa051331.27943278
31NF-kappa B signaling pathway_Homo sapiens_hsa040641.23150780
32Herpes simplex infection_Homo sapiens_hsa051681.22750153
33ABC transporters_Homo sapiens_hsa020101.22293103
34Fatty acid metabolism_Homo sapiens_hsa012121.21963362
35Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.19577879
36* Lysosome_Homo sapiens_hsa041421.19495364
37Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17273733
38Bile secretion_Homo sapiens_hsa049761.12002497
39Drug metabolism - other enzymes_Homo sapiens_hsa009831.11950074
40Osteoclast differentiation_Homo sapiens_hsa043801.09890236
41Starch and sucrose metabolism_Homo sapiens_hsa005001.09381834
42Glycosaminoglycan degradation_Homo sapiens_hsa005311.08445666
43Butanoate metabolism_Homo sapiens_hsa006501.06536579
44Tyrosine metabolism_Homo sapiens_hsa003501.06019580
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.05629022
46Propanoate metabolism_Homo sapiens_hsa006401.04868801
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.03355079
48Vitamin digestion and absorption_Homo sapiens_hsa049771.02556003
49Other glycan degradation_Homo sapiens_hsa005111.01672296
50Selenocompound metabolism_Homo sapiens_hsa004500.99067447
51Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95721590
52Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.94960958
53Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93672030
54Legionellosis_Homo sapiens_hsa051340.93112149
55Malaria_Homo sapiens_hsa051440.92970734
56Tuberculosis_Homo sapiens_hsa051520.91714546
57Systemic lupus erythematosus_Homo sapiens_hsa053220.88975594
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84021374
59Toxoplasmosis_Homo sapiens_hsa051450.83982985
60Sulfur metabolism_Homo sapiens_hsa009200.82155480
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79719996
62Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.79338919
63Graft-versus-host disease_Homo sapiens_hsa053320.79205661
64Acute myeloid leukemia_Homo sapiens_hsa052210.79025107
65NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78781259
66B cell receptor signaling pathway_Homo sapiens_hsa046620.77357082
67RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75306656
68TNF signaling pathway_Homo sapiens_hsa046680.74462302
69Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.74305306
70Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.74176443
71Steroid biosynthesis_Homo sapiens_hsa001000.74047266
72T cell receptor signaling pathway_Homo sapiens_hsa046600.74010705
73Fat digestion and absorption_Homo sapiens_hsa049750.72067268
74Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70077207
75Antigen processing and presentation_Homo sapiens_hsa046120.69976501
76Hepatitis B_Homo sapiens_hsa051610.69253405
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.69178099
78Phagosome_Homo sapiens_hsa041450.68835265
79AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.68364349
80Influenza A_Homo sapiens_hsa051640.67021052
81Measles_Homo sapiens_hsa051620.66780385
82Allograft rejection_Homo sapiens_hsa053300.66488740
83Sphingolipid metabolism_Homo sapiens_hsa006000.65486744
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.65404779
85Rheumatoid arthritis_Homo sapiens_hsa053230.65111814
86Folate biosynthesis_Homo sapiens_hsa007900.65005805
87Prion diseases_Homo sapiens_hsa050200.64093121
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63483374
89Shigellosis_Homo sapiens_hsa051310.63413038
90Fatty acid elongation_Homo sapiens_hsa000620.62867556
91Arginine and proline metabolism_Homo sapiens_hsa003300.62721927
92Collecting duct acid secretion_Homo sapiens_hsa049660.61151246
93Glutathione metabolism_Homo sapiens_hsa004800.60589540
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.59306803
952-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.58131728
96Epstein-Barr virus infection_Homo sapiens_hsa051690.57795706
97Fructose and mannose metabolism_Homo sapiens_hsa000510.56302582
98Hepatitis C_Homo sapiens_hsa051600.55993225
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55477789
100Leukocyte transendothelial migration_Homo sapiens_hsa046700.54109864
101Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.51905830
102Galactose metabolism_Homo sapiens_hsa000520.51365532
103Bladder cancer_Homo sapiens_hsa052190.51181097
104Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.50476011
105Renin-angiotensin system_Homo sapiens_hsa046140.49195281
106African trypanosomiasis_Homo sapiens_hsa051430.49038855
107Cysteine and methionine metabolism_Homo sapiens_hsa002700.48376593
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.46990269
109* Apoptosis_Homo sapiens_hsa042100.46966121
110Adipocytokine signaling pathway_Homo sapiens_hsa049200.46738711
111Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.46720003
112Pyruvate metabolism_Homo sapiens_hsa006200.46662236
113Jak-STAT signaling pathway_Homo sapiens_hsa046300.46057884
114Vibrio cholerae infection_Homo sapiens_hsa051100.45668606
115Amoebiasis_Homo sapiens_hsa051460.45656748
116Mineral absorption_Homo sapiens_hsa049780.45440883
117VEGF signaling pathway_Homo sapiens_hsa043700.44430736
118Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.44071957
119Primary immunodeficiency_Homo sapiens_hsa053400.43685707
120Hematopoietic cell lineage_Homo sapiens_hsa046400.42497751
121Lysine degradation_Homo sapiens_hsa003100.42188036
122Platelet activation_Homo sapiens_hsa046110.40927596
123HTLV-I infection_Homo sapiens_hsa051660.40579712
124Chemokine signaling pathway_Homo sapiens_hsa040620.40283033
125Neurotrophin signaling pathway_Homo sapiens_hsa047220.38466804
126Fatty acid biosynthesis_Homo sapiens_hsa000610.38443549
127Asthma_Homo sapiens_hsa053100.38372015
128Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.38279327
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38232218
130Salmonella infection_Homo sapiens_hsa051320.37840753
131Pancreatic cancer_Homo sapiens_hsa052120.37560792
132Insulin resistance_Homo sapiens_hsa049310.36712780
133Prolactin signaling pathway_Homo sapiens_hsa049170.36203283
134Endocytosis_Homo sapiens_hsa041440.35679826
135Carbohydrate digestion and absorption_Homo sapiens_hsa049730.35413869
136Carbon metabolism_Homo sapiens_hsa012000.35348503
137HIF-1 signaling pathway_Homo sapiens_hsa040660.32102475
138Renal cell carcinoma_Homo sapiens_hsa052110.30768954
139Chronic myeloid leukemia_Homo sapiens_hsa052200.30165568
140Viral carcinogenesis_Homo sapiens_hsa052030.29949248
141Pentose phosphate pathway_Homo sapiens_hsa000300.26392022
142Non-small cell lung cancer_Homo sapiens_hsa052230.26209700
143Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25199281
144GnRH signaling pathway_Homo sapiens_hsa049120.24917927
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.22459722
146Notch signaling pathway_Homo sapiens_hsa043300.20841826
147Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20023731
148Cyanoamino acid metabolism_Homo sapiens_hsa004600.17846481

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