CTSK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysosomal cysteine proteinase involved in bone remodeling and resorption. This protein, which is a member of the peptidase C1 protein family, is predominantly expressed in osteoclasts. However, the encoded protein is also expressed in a significant fraction of human breast cancers, where it could contribute to tumor invasiveness. Mutations in this gene are the cause of pycnodysostosis, an autosomal recessive disease characterized by osteosclerosis and short stature. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of complement activation (GO:0045916)6.59034638
2keratan sulfate catabolic process (GO:0042340)6.27592009
3protein heterotrimerization (GO:0070208)6.16510435
4detection of molecule of bacterial origin (GO:0032490)5.69321330
5skin morphogenesis (GO:0043589)5.57584205
6positive regulation of respiratory burst (GO:0060267)5.49201378
7collagen fibril organization (GO:0030199)5.43561983
8negative regulation of protein activation cascade (GO:2000258)5.31637146
9cell migration involved in heart development (GO:0060973)5.16978150
10opsonization (GO:0008228)4.81039772
11mesenchymal-epithelial cell signaling (GO:0060638)4.76500742
12positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)4.74816358
13negative regulation of humoral immune response (GO:0002921)4.59983494
14* collagen catabolic process (GO:0030574)4.58620432
15* collagen metabolic process (GO:0032963)4.54750804
16macrophage activation involved in immune response (GO:0002281)4.38789464
17* multicellular organismal macromolecule metabolic process (GO:0044259)4.24248893
18* multicellular organismal catabolic process (GO:0044243)4.20263646
19adhesion of symbiont to host cell (GO:0044650)4.14767537
20virion attachment to host cell (GO:0019062)4.14767537
21leukocyte migration involved in inflammatory response (GO:0002523)4.06421963
22sequestering of extracellular ligand from receptor (GO:0035581)4.04200406
23* multicellular organismal metabolic process (GO:0044236)4.00204575
24extracellular fibril organization (GO:0043206)3.88981642
25bone trabecula formation (GO:0060346)3.81268131
26* extracellular matrix disassembly (GO:0022617)3.78388428
27barbed-end actin filament capping (GO:0051016)3.73687415
28negative regulation of leukocyte chemotaxis (GO:0002689)3.71109640
29peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.67665868
30adhesion of symbiont to host (GO:0044406)3.64106479
31regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.62432736
32regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.61365729
33endodermal cell differentiation (GO:0035987)3.53213005
34detection of external biotic stimulus (GO:0098581)3.51623353
35fibril organization (GO:0097435)3.51008633
36positive regulation by symbiont of host defense response (GO:0052509)3.49456145
37modulation by symbiont of host defense response (GO:0052031)3.49456145
38modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.49456145
39modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.49456145
40positive regulation by organism of defense response of other organism involved in symbiotic interact3.49456145
41modulation by symbiont of host immune response (GO:0052553)3.49456145
42chondrocyte proliferation (GO:0035988)3.46447786
43basement membrane organization (GO:0071711)3.45821742
44kidney mesenchyme development (GO:0072074)3.44310965
45metanephric mesenchyme development (GO:0072075)3.41861903
46type B pancreatic cell proliferation (GO:0044342)3.41733401
47positive regulation of macrophage activation (GO:0043032)3.41732884
48chondroitin sulfate catabolic process (GO:0030207)3.36525134
49positive regulation of osteoblast proliferation (GO:0033690)3.33507706
50regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.30638853
51negative regulation of nitric oxide biosynthetic process (GO:0045019)3.27410052
52extracellular matrix assembly (GO:0085029)3.23605731
53decidualization (GO:0046697)3.23181324
54hyaluronan catabolic process (GO:0030214)3.15333647
55regulation of mononuclear cell migration (GO:0071675)3.15125511
56regulation of macrophage cytokine production (GO:0010935)3.13126280
57apoptotic cell clearance (GO:0043277)3.12479082
58cell adhesion mediated by integrin (GO:0033627)3.08790174
59vascular endothelial growth factor signaling pathway (GO:0038084)3.06517754
60regulation of integrin-mediated signaling pathway (GO:2001044)3.06505433
61regulation of monocyte chemotaxis (GO:0090025)3.03792991
62extracellular negative regulation of signal transduction (GO:1900116)3.00480026
63extracellular regulation of signal transduction (GO:1900115)3.00480026
64detection of biotic stimulus (GO:0009595)2.98596086
65negative regulation of biomineral tissue development (GO:0070168)2.98376228
66regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.96368753
67positive regulation of toll-like receptor signaling pathway (GO:0034123)2.93824007
68glomerular filtration (GO:0003094)2.92957478
69phagocytosis, recognition (GO:0006910)2.90861302
70glial cell migration (GO:0008347)2.89594202
71positive regulation of p38MAPK cascade (GO:1900745)2.88670600
72dermatan sulfate biosynthetic process (GO:0030208)2.87387016
73* extracellular matrix organization (GO:0030198)2.86888121
74blood vessel maturation (GO:0001955)2.86477877
75* extracellular structure organization (GO:0043062)2.85605105
76glycosphingolipid catabolic process (GO:0046479)2.84920088
77positive regulation of macrophage cytokine production (GO:0060907)2.84640066
78positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.83934388
79chondrocyte development (GO:0002063)2.83875151
80negative regulation of protein localization to plasma membrane (GO:1903077)2.83336814
81substrate-dependent cell migration (GO:0006929)2.82838210
82middle ear morphogenesis (GO:0042474)2.82096378
83cellular response to vitamin D (GO:0071305)2.81200910
84negative regulation of smooth muscle cell migration (GO:0014912)2.81109763
85glycosylceramide metabolic process (GO:0006677)2.81067573
86negative regulation of BMP signaling pathway (GO:0030514)2.80475203
87positive regulation of endothelial cell apoptotic process (GO:2000353)2.79148866
88regulation of complement activation (GO:0030449)2.79091567
89cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.76905502
90regulation of membrane protein ectodomain proteolysis (GO:0051043)2.76154313
91endothelial cell proliferation (GO:0001935)2.71472177
92regulation of chemokine-mediated signaling pathway (GO:0070099)2.71274107
93peptidyl-proline hydroxylation (GO:0019511)2.68411678
94cellular response to thyroid hormone stimulus (GO:0097067)2.66687188
95stress fiber assembly (GO:0043149)2.66611649
96biomineral tissue development (GO:0031214)2.66360918
97cellular response to cadmium ion (GO:0071276)2.66307327
98glycosaminoglycan catabolic process (GO:0006027)2.64394999
99regulation of extracellular matrix disassembly (GO:0010715)2.63306042
100cellular response to vitamin (GO:0071295)2.62168721
101protein localization to endosome (GO:0036010)2.62002613
102response to lipoprotein particle (GO:0055094)2.61561073
103positive regulation of extracellular matrix organization (GO:1903055)2.59854647
104dermatan sulfate metabolic process (GO:0030205)2.59447758
105renal filtration (GO:0097205)2.56691388
106smooth muscle tissue development (GO:0048745)2.55867637
107protein hydroxylation (GO:0018126)2.54860175
108negative regulation of cell junction assembly (GO:1901889)2.54309369
109negative regulation of adherens junction organization (GO:1903392)2.54309369
110negative regulation of focal adhesion assembly (GO:0051895)2.54309369
111positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.54066070
112regulation of collagen metabolic process (GO:0010712)2.53817580
113angiogenesis involved in wound healing (GO:0060055)2.53776024
114glycolipid catabolic process (GO:0019377)2.53093438
115embryo implantation (GO:0007566)2.52497049
116protein localization to cell surface (GO:0034394)2.52273748
117regulation of apoptotic cell clearance (GO:2000425)2.52273548
118macrophage activation (GO:0042116)2.51073763
119embryonic cranial skeleton morphogenesis (GO:0048701)2.50838421
120protein trimerization (GO:0070206)2.50473185
121endocardial cushion development (GO:0003197)2.50280813
122ovulation from ovarian follicle (GO:0001542)2.50112292
123keratan sulfate metabolic process (GO:0042339)2.49690718
124regulation of granulocyte chemotaxis (GO:0071622)2.47823945
125neuron projection extension involved in neuron projection guidance (GO:1902284)2.47270030
126axon extension involved in axon guidance (GO:0048846)2.47270030
127pinocytosis (GO:0006907)2.47170618
128pathway-restricted SMAD protein phosphorylation (GO:0060389)2.46788432
129lipopolysaccharide-mediated signaling pathway (GO:0031663)2.46532589
130tooth mineralization (GO:0034505)2.45955077
131chondroitin sulfate biosynthetic process (GO:0030206)2.45305539
132cellular response to amino acid stimulus (GO:0071230)2.45253167
133aminoglycan catabolic process (GO:0006026)2.45081499
134regulation of early endosome to late endosome transport (GO:2000641)2.44951715
135positive regulation of receptor recycling (GO:0001921)2.44311833
136regulation of protein activation cascade (GO:2000257)2.44144550
137cortical actin cytoskeleton organization (GO:0030866)2.43765673
138vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.43404010
139negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.42922171
140positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.41994628
141negative regulation of establishment of protein localization to plasma membrane (GO:0090005)2.41531823
142negative regulation of homotypic cell-cell adhesion (GO:0034111)2.41314925
143sulfur compound catabolic process (GO:0044273)2.41159074
144regulation of leukocyte chemotaxis (GO:0002688)2.40608072
145branching involved in salivary gland morphogenesis (GO:0060445)2.39078865
146glomerular basement membrane development (GO:0032836)2.38999529
147endothelial cell morphogenesis (GO:0001886)2.38652966
148neutrophil activation involved in immune response (GO:0002283)2.37958594
149wound healing, spreading of epidermal cells (GO:0035313)2.37956437

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human6.56748362
2RARG_19884340_ChIP-ChIP_MEFs_Mouse4.16260902
3PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse4.06883262
4TP63_17297297_ChIP-ChIP_HaCaT_Human2.90902523
5ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.89422426
6TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.87847287
7CLOCK_20551151_ChIP-Seq_293T_Human2.73650698
8IRF8_21731497_ChIP-ChIP_J774_Mouse2.62780824
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.60465320
10CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.49886718
11CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.47018127
12CDX2_19796622_ChIP-Seq_MESCs_Mouse2.42811564
13TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.38062413
14Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.35031135
15CJUN_26792858_Chip-Seq_BT549_Human2.32261391
16NFE2L2_20460467_ChIP-Seq_MEFs_Mouse2.27458912
17NRF2_20460467_ChIP-Seq_MEFs_Mouse2.27458912
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.20059575
19RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.07398219
20ESR1_21235772_ChIP-Seq_MCF-7_Human2.05186953
21* IRF8_27001747_Chip-Seq_BMDM_Mouse1.92628271
22WT1_19549856_ChIP-ChIP_CCG9911_Human1.87389639
23SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.85274604
24GATA2_21666600_ChIP-Seq_HMVEC_Human1.80904830
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.80883611
26NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.78160670
27SOX2_20726797_ChIP-Seq_SW620_Human1.76307131
28IRF8_22096565_ChIP-ChIP_GC-B_Human1.75253393
29FOXO3_23340844_ChIP-Seq_DLD1_Human1.67385434
30NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.64932013
31SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.64372973
32TP53_16413492_ChIP-PET_HCT116_Human1.63618156
33* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.60102950
34EP300_21415370_ChIP-Seq_HL-1_Mouse1.59824765
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.59088840
36THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.58202689
37* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.57984266
38PPAR_26484153_Chip-Seq_NCI-H1993_Human1.57700806
39* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.56754863
40ESR2_21235772_ChIP-Seq_MCF-7_Human1.56354525
41* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.50713724
42ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.49206760
43FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.48238842
44ELK3_25401928_ChIP-Seq_HUVEC_Human1.46572090
45* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44224227
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.42951039
47CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.42661798
48SALL4_18804426_ChIP-ChIP_XEN_Mouse1.38014647
49SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.37692550
50SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.36281431
51SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.36281431
52VDR_24787735_ChIP-Seq_THP-1_Human1.34466816
53SMC1_22415368_ChIP-Seq_MEFs_Mouse1.27294293
54AR_21572438_ChIP-Seq_LNCaP_Human1.27190148
55* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.25169713
56BRD4_25478319_ChIP-Seq_HGPS_Human1.21276850
57NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.20675399
58WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18259428
59SOX9_24532713_ChIP-Seq_HFSC_Mouse1.14421629
60P300_27058665_Chip-Seq_ZR-75-30cells_Human1.13497433
61BRD4_27068464_Chip-Seq_AML-cells_Mouse1.12854232
62HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.08209756
63EED_16625203_ChIP-ChIP_MESCs_Mouse1.08173163
64TP53_20018659_ChIP-ChIP_R1E_Mouse1.06257069
65FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.06249705
66UBF1/2_26484160_Chip-Seq_HMECs_Human1.04638079
67TBX20_22328084_ChIP-Seq_HEART_Mouse1.02584040
68TBX20_22080862_ChIP-Seq_HEART_Mouse1.02584040
69SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.02087913
70* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.01216006
71TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00479061
72RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99163436
73SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98954341
74PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.98200722
75TP53_18474530_ChIP-ChIP_U2OS_Human0.97962877
76MTF2_20144788_ChIP-Seq_MESCs_Mouse0.97897191
77PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97735254
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95834697
79EZH2_18974828_ChIP-Seq_MESCs_Mouse0.95615382
80RNF2_18974828_ChIP-Seq_MESCs_Mouse0.95615382
81TP53_22127205_ChIP-Seq_IMR90_Human0.95559794
82GATA1_22025678_ChIP-Seq_K562_Human0.95527880
83EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95489990
84SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94373552
85SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.92928775
86NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92469145
87SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.91181747
88RACK7_27058665_Chip-Seq_MCF-7_Human0.91058698
89* CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.90802582
90SMC3_22415368_ChIP-Seq_MEFs_Mouse0.90334673
91* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.89983348
92KDM2B_26808549_Chip-Seq_SUP-B15_Human0.89217036
93VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88541089
94ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88154482
95MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88029837
96IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87879145
97* CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87835505
98SA1_22415368_ChIP-Seq_MEFs_Mouse0.87822318
99STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87290212
100PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.84466394
101TP53_23651856_ChIP-Seq_MEFs_Mouse0.84313895
102LXR_22292898_ChIP-Seq_THP-1_Human0.83566616
103* TP63_23658742_ChIP-Seq_EP156T_Human0.82142620
104PIAS1_25552417_ChIP-Seq_VCAP_Human0.81394031
105KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81349148
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.80850914
107ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.80480970
108RXR_22158963_ChIP-Seq_LIVER_Mouse0.80130411
109AHR_22903824_ChIP-Seq_MCF-7_Human0.80071804
110PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.79345543
111STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.79224790
112EGR1_19032775_ChIP-ChIP_M12_Human0.79179672
113NFI_21473784_ChIP-Seq_ESCs_Mouse0.78727081
114SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.78723575
115SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.78270016
116ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.78138271
117WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77775643
118PU_27001747_Chip-Seq_BMDM_Mouse0.77710418
119HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77158299
120JARID2_20075857_ChIP-Seq_MESCs_Mouse0.77071730
121NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.76410890
122FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.75110332

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen8.76053653
2MP0005503_abnormal_tendon_morphology5.72185826
3MP0005275_abnormal_skin_tensile5.13902280
4MP0006054_spinal_hemorrhage3.85267869
5MP0001958_emphysema3.81714194
6MP0003279_aneurysm3.35927890
7* MP0001542_abnormal_bone_strength2.80759465
8MP0005058_abnormal_lysosome_morphology2.77271862
9MP0003705_abnormal_hypodermis_morpholog2.38746568
10* MP0002998_abnormal_bone_remodeling2.30536574
11MP0004272_abnormal_basement_membrane2.23394205
12MP0005257_abnormal_intraocular_pressure2.22668598
13MP0002254_reproductive_system_inflammat2.12517497
14* MP0005508_abnormal_skeleton_morphology1.88846838
15MP0005164_abnormal_response_to1.88309962
16MP0002060_abnormal_skin_morphology1.74255852
17MP0002295_abnormal_pulmonary_circulatio1.72942347
18MP0004883_abnormal_blood_vessel1.71065379
19MP0005023_abnormal_wound_healing1.64890220
20MP0006082_CNS_inflammation1.64864252
21MP0003300_gastrointestinal_ulcer1.64526473
22* MP0002896_abnormal_bone_mineralization1.62865986
23* MP0001533_abnormal_skeleton_physiology1.61227123
24MP0000343_altered_response_to1.59829252
25MP0003566_abnormal_cell_adhesion1.57424386
26MP0003172_abnormal_lysosome_physiology1.55716993
27* MP0005390_skeleton_phenotype1.54879269
28MP0002933_joint_inflammation1.52858000
29MP0002108_abnormal_muscle_morphology1.52315518
30MP0009384_cardiac_valve_regurgitation1.39902238
31MP0005171_absent_coat_pigmentation1.37893990
32MP0001243_abnormal_dermal_layer1.36235214
33MP0004510_myositis1.35877259
34MP0003448_altered_tumor_morphology1.33815891
35* MP0003795_abnormal_bone_structure1.31889524
36MP0009250_abnormal_appendicular_skeleto1.30328008
37* MP0002115_abnormal_skeleton_extremities1.30119219
38MP0003191_abnormal_cellular_cholesterol1.23096069
39MP0000767_abnormal_smooth_muscle1.21734698
40MP0005623_abnormal_meninges_morphology1.18601419
41MP0000372_irregular_coat_pigmentation1.18149134
42MP0001879_abnormal_lymphatic_vessel1.16050412
43MP0000920_abnormal_myelination1.14164185
44MP0001299_abnormal_eye_distance/1.12889928
45* MP0002419_abnormal_innate_immunity1.12303737
46* MP0000604_amyloidosis1.11597754
47MP0003283_abnormal_digestive_organ1.11574937
48* MP0000163_abnormal_cartilage_morphology1.11490899
49MP0002282_abnormal_trachea_morphology1.07102421
50* MP0002113_abnormal_skeleton_development1.02424369
51MP0002837_dystrophic_cardiac_calcinosis1.01556779
52MP0009840_abnormal_foam_cell1.01187485
53MP0004185_abnormal_adipocyte_glucose1.00977866
54MP0004134_abnormal_chest_morphology0.99184788
55MP0003950_abnormal_plasma_membrane0.97152263
56MP0003195_calcinosis0.97076215
57MP0003091_abnormal_cell_migration0.96450122
58MP0002877_abnormal_melanocyte_morpholog0.95271306
59MP0000751_myopathy0.95205333
60MP0002148_abnormal_hypersensitivity_rea0.91945451
61MP0005166_decreased_susceptibility_to0.90189043
62MP0004858_abnormal_nervous_system0.89045735
63MP0001849_ear_inflammation0.88897231
64MP0002133_abnormal_respiratory_system0.88235907
65MP0005388_respiratory_system_phenotype0.88235907
66MP0000858_altered_metastatic_potential0.85764666
67MP0003436_decreased_susceptibility_to0.85546182
68MP0010352_gastrointestinal_tract_polyps0.85425816
69MP0009785_altered_susceptibility_to0.84855901
70MP0003303_peritoneal_inflammation0.83589567
71MP0008260_abnormal_autophagy0.79280071
72MP0000249_abnormal_blood_vessel0.78987447
73MP0003690_abnormal_glial_cell0.78065182
74MP0005408_hypopigmentation0.76158226
75MP0010368_abnormal_lymphatic_system0.71069886
76MP0009278_abnormal_bone_marrow0.70355572
77MP0000733_abnormal_muscle_development0.70245189
78MP0001915_intracranial_hemorrhage0.69996383
79MP0000428_abnormal_craniofacial_morphol0.69482827
80MP0002168_other_aberrant_phenotype0.68754186
81MP0003329_amyloid_beta_deposits0.66688502
82MP0003941_abnormal_skin_development0.65387463
83MP0000685_abnormal_immune_system0.65028554
84MP0003075_altered_response_to0.64745647
85MP0000371_diluted_coat_color0.64592202
86MP0000013_abnormal_adipose_tissue0.64236349
87MP0009764_decreased_sensitivity_to0.63618494
88MP0003634_abnormal_glial_cell0.63232546
89MP0005193_abnormal_anterior_eye0.61689196
90MP0001614_abnormal_blood_vessel0.61145583
91MP0002128_abnormal_blood_circulation0.61037382
92MP0001790_abnormal_immune_system0.60676237
93MP0005387_immune_system_phenotype0.60676237
94MP0003385_abnormal_body_wall0.60566749
95* MP0000432_abnormal_head_morphology0.59971151
96* MP0001175_abnormal_lung_morphology0.59526906
97MP0001348_abnormal_lacrimal_gland0.59104185
98MP0000015_abnormal_ear_pigmentation0.58587450
99MP0005174_abnormal_tail_pigmentation0.58354382
100MP0001851_eye_inflammation0.58151651
101MP0005197_abnormal_uvea_morphology0.57937260
102MP0000749_muscle_degeneration0.57570145
103MP0003567_abnormal_fetal_cardiomyocyte0.57562759
104MP0000569_abnormal_digit_pigmentation0.57460241
105MP0010030_abnormal_orbit_morphology0.57380670
106MP0004084_abnormal_cardiac_muscle0.57223150
107MP0005165_increased_susceptibility_to0.56908593
108MP0005595_abnormal_vascular_smooth0.56837373
109MP0003828_pulmonary_edema0.55641705
110MP0004484_altered_response_of0.54539345
111MP0000465_gastrointestinal_hemorrhage0.54389650
112MP0003724_increased_susceptibility_to0.54375732
113MP0003045_fibrosis0.54142948
114MP0001177_atelectasis0.53950629
115MP0005248_abnormal_Harderian_gland0.53148194
116MP0000750_abnormal_muscle_regeneration0.52904639
117MP0009780_abnormal_chondrocyte_physiolo0.52391543
118MP0001835_abnormal_antigen_presentation0.51729240
119MP0010386_abnormal_urinary_bladder0.51396174
120MP0010771_integument_phenotype0.51170420
121* MP0002109_abnormal_limb_morphology0.48445396
122MP0000759_abnormal_skeletal_muscle0.48280069

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)7.95056434
2Protrusio acetabuli (HP:0003179)6.82234775
3Broad metatarsal (HP:0001783)4.72156855
4Aortic dissection (HP:0002647)4.60987011
5Soft skin (HP:0000977)4.42965403
6Cervical subluxation (HP:0003308)4.36159501
7Atrophic scars (HP:0001075)4.00713945
8* Wormian bones (HP:0002645)3.76801857
9Vertebral compression fractures (HP:0002953)3.75920789
10Abnormality of dentin (HP:0010299)3.67625693
11Ankle contracture (HP:0006466)3.61416788
12Bladder diverticulum (HP:0000015)3.59380040
13Shallow orbits (HP:0000586)3.54267319
14Aortic aneurysm (HP:0004942)3.48805900
15Peritonitis (HP:0002586)3.48260247
16Vascular tortuosity (HP:0004948)3.41267491
17Cerebral aneurysm (HP:0004944)3.39511484
18Ulnar bowing (HP:0003031)3.39402405
19Purpura (HP:0000979)3.31911985
20Biconcave vertebral bodies (HP:0004586)3.28841211
21Follicular hyperkeratosis (HP:0007502)3.28420851
22Dysostosis multiplex (HP:0000943)3.24486565
23Metaphyseal dysplasia (HP:0100255)3.23487662
24Arterial tortuosity (HP:0005116)3.22570817
25Mucopolysacchariduria (HP:0008155)3.22557693
26Urinary glycosaminoglycan excretion (HP:0003541)3.22557693
27* Blue sclerae (HP:0000592)3.21379970
28Abnormal delivery (HP:0001787)3.09079786
29Fragile skin (HP:0001030)3.06533404
30Vacuolated lymphocytes (HP:0001922)3.01459605
31Mild short stature (HP:0003502)3.00700810
32Systemic lupus erythematosus (HP:0002725)3.00275541
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.98164576
34Abnormality of polysaccharide metabolism (HP:0011012)2.98164576
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.98164576
36Hydroxyprolinuria (HP:0003080)2.91162619
37Abnormality of proline metabolism (HP:0010907)2.91162619
38Nonimmune hydrops fetalis (HP:0001790)2.89614360
39Neonatal short-limb short stature (HP:0008921)2.89596456
40* Osteolytic defects of the phalanges of the hand (HP:0009771)2.89339170
41* Osteolytic defects of the hand bones (HP:0009699)2.89339170
42Overgrowth (HP:0001548)2.84804648
43Redundant skin (HP:0001582)2.82216296
44Flared iliac wings (HP:0002869)2.81849178
45Dilatation of the ascending aorta (HP:0005111)2.81583241
46Femoral bowing (HP:0002980)2.80299538
47Hyperextensible skin (HP:0000974)2.79539710
48Increased cerebral lipofuscin (HP:0011813)2.78019009
49Coxa vara (HP:0002812)2.69138402
50Autoimmune thrombocytopenia (HP:0001973)2.65828386
51Irregular vertebral endplates (HP:0003301)2.64942630
52Mitral valve prolapse (HP:0001634)2.64236379
53Genu recurvatum (HP:0002816)2.59449245
54Pulmonary artery stenosis (HP:0004415)2.57612244
55Type 1 muscle fiber predominance (HP:0003803)2.56476008
56Ovoid vertebral bodies (HP:0003300)2.55266136
57Abnormality of the vertebral endplates (HP:0005106)2.54512065
58Increased neuronal autofluorescent lipopigment (HP:0002074)2.51634786
59Beaking of vertebral bodies (HP:0004568)2.50213644
60Abnormality of the acetabulum (HP:0003170)2.48573966
61Osteoarthritis (HP:0002758)2.41902419
62Increased variability in muscle fiber diameter (HP:0003557)2.39241433
63Bowel diverticulosis (HP:0005222)2.37860423
64Platyspondyly (HP:0000926)2.37549090
65Wide anterior fontanel (HP:0000260)2.36387418
66Asymmetric septal hypertrophy (HP:0001670)2.34862728
67Metaphyseal cupping (HP:0003021)2.30465441
68Spinal rigidity (HP:0003306)2.28168396
69Eczematoid dermatitis (HP:0000976)2.26356687
70Turricephaly (HP:0000262)2.25890960
71Abnormality of liposaccharide metabolism (HP:0010968)2.24398050
72Abnormality of glycosphingolipid metabolism (HP:0004343)2.24398050
73Abnormality of glycolipid metabolism (HP:0010969)2.24398050
74Abnormal cartilage morphology (HP:0002763)2.24336472
75Bowed forearm bones (HP:0003956)2.23924779
76Bowing of the arm (HP:0006488)2.23924779
77Axonal loss (HP:0003447)2.23404218
78Joint laxity (HP:0001388)2.23091106
79Wrist flexion contracture (HP:0001239)2.22182410
80Slender build (HP:0001533)2.21612379
81Abnormality of macrophages (HP:0004311)2.20504875
82Coronal craniosynostosis (HP:0004440)2.19770156
83Breech presentation (HP:0001623)2.18904286
84Abnormality of complement system (HP:0005339)2.17761072
85Aneurysm (HP:0002617)2.17309984
86Tibial bowing (HP:0002982)2.17098085
87Aortic valve stenosis (HP:0001650)2.16778416
88Mildly elevated creatine phosphokinase (HP:0008180)2.15912280
89Thoracolumbar scoliosis (HP:0002944)2.15615443
90Elbow flexion contracture (HP:0002987)2.13788527
91Radial bowing (HP:0002986)2.11279848
92Mitral regurgitation (HP:0001653)2.10598452
93* Delayed closure of the anterior fontanelle (HP:0001476)2.08717313
94Aortic regurgitation (HP:0001659)2.08411229
95Emphysema (HP:0002097)2.05914332
96Ulnar deviation of the wrist (HP:0003049)2.04548798
97Joint stiffness (HP:0001387)2.03817179
98Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03208171
99Nuclear cataract (HP:0100018)2.02741024
100Myocardial infarction (HP:0001658)2.01454961
101Abnormality of the lumbar spine (HP:0100712)2.01453917
102* Spondylolisthesis (HP:0003302)2.01398918
103Mitral stenosis (HP:0001718)2.00801534
104Cupped ribs (HP:0000887)1.99856902
105Disproportionate tall stature (HP:0001519)1.99510339
106Craniofacial hyperostosis (HP:0004493)1.98275916
107Hypoplasia of the odontoid process (HP:0003311)1.97390452
108Abnormality of skull ossification (HP:0002703)1.96157380
109Protuberant abdomen (HP:0001538)1.95133991
110Short hallux (HP:0010109)1.94712491
111* Delayed cranial suture closure (HP:0000270)1.93611124
112Abnormality of skeletal muscle fiber size (HP:0012084)1.93213780
113Conjunctival telangiectasia (HP:0000524)1.92395614
114Inguinal hernia (HP:0000023)1.90679487
115J-shaped sella turcica (HP:0002680)1.90146611
116Enlarged epiphyses (HP:0010580)1.89840806
117Increased connective tissue (HP:0009025)1.89439383
118Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.89182270
119Hypoventilation (HP:0002791)1.83060057
120Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.83059519
121Gingival overgrowth (HP:0000212)1.82519652
122Neurofibrillary tangles (HP:0002185)1.82089909
123Osteopenia (HP:0000938)1.81963116
124Bell-shaped thorax (HP:0001591)1.81740609
125Natal tooth (HP:0000695)1.81669473
126Asymmetry of the thorax (HP:0001555)1.81515169
127Broad ribs (HP:0000885)1.81285187
128Cardiovascular calcification (HP:0011915)1.79717343
129Generalized amyotrophy (HP:0003700)1.78588044
130Spinal cord lesions (HP:0100561)1.76376177
131Syringomyelia (HP:0003396)1.76376177
132Complement deficiency (HP:0004431)1.75890958
133Skin nodule (HP:0200036)1.75651594

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.43503505
2TGFBR23.40508119
3ERN12.99106894
4PBK2.73621204
5TRIB32.56065665
6PDGFRA2.55297621
7TRPM72.52311662
8BMX2.50737092
9PKN22.41791254
10EPHB12.37653727
11TTN2.37069150
12MET2.23702875
13CDC42BPA2.18534159
14LIMK12.03145444
15GRK71.87984369
16EPHA31.76786420
17KIT1.67695533
18PRKD21.59183641
19PAK41.58679829
20ABL21.57437826
21FGFR21.55481265
22FGR1.54335118
23NME21.53779994
24MST1R1.49145047
25ADRBK21.47218790
26BLK1.46594887
27TBK11.44304345
28TESK11.42783315
29EPHB21.42772148
30MYLK1.40438446
31LRRK21.39924807
32NTRK11.39698638
33RIPK11.36136730
34PIK3CG1.32614458
35MAP3K61.31819416
36PDK21.29925498
37DMPK1.28303956
38MAPKAPK51.25307397
39NEK91.21677520
40ERBB31.21600969
41PDGFRB1.20645270
42AKT31.19062586
43ROCK21.16158139
44GRK51.14077920
45ARAF1.09820200
46FGFR11.04460834
47ADRBK11.03410524
48PAK21.03264249
49STK391.03077754
50SIK10.98408328
51PIM20.97221716
52TYK20.96218997
53TGFBR10.93373921
54ILK0.93258766
55STK30.92682998
56STK380.92104984
57PTK2B0.91656091
58TAOK20.91363936
59FGFR40.90791432
60IRAK30.90709541
61ROCK10.88406618
62FER0.87852510
63MAP2K30.87808646
64MAP3K20.85976908
65PRKCH0.84371967
66MOS0.83548855
67PRPF4B0.83346085
68FLT30.83271338
69PLK20.83021192
70PTK60.81834761
71MAP3K30.79898894
72HCK0.78394224
73GRK10.77667207
74RPS6KA20.77533335
75MAPKAPK30.71896770
76PRKG20.71318903
77JAK30.70813515
78GSK3A0.70052849
79PRKD10.68936439
80DAPK30.68476080
81CSK0.68223400
82CSNK1A1L0.68025271
83NLK0.67914916
84MAPK120.67385509
85MAP3K140.65809888
86EGFR0.65436414
87FGFR30.65208382
88PDPK10.64958568
89CAMKK20.64266550
90ZAP700.61815779
91MARK30.61513247
92MAP3K130.60648718
93PTK20.60510455
94PAK10.60378854
95JAK10.59856114
96ERBB40.59752741
97INSR0.59093033
98BCR0.57956792
99LATS10.57022210
100CSNK1G30.56509195
101PKN10.55621873
102ABL10.54887053
103SRC0.53979401
104KSR20.51463046
105CAMK1D0.51437157
106CSNK1G10.51293714
107SCYL20.49568790
108RET0.49087199
109CSNK1G20.48746056
110FYN0.46625305
111PAK30.46359744
112OXSR10.45920630
113MAPKAPK20.45064249
114IGF1R0.44982184
115IKBKB0.43616047
116MAPK70.42904670
117IKBKE0.42901632
118RPS6KL10.41678978
119RPS6KC10.41678978
120MAP2K20.41655459
121PAK60.41613346
122GRK60.41001556
123MARK20.40831268
124LATS20.40546660
125CDK60.38582945
126MAP3K120.38173401
127DYRK1B0.38028776
128MAP3K10.37632054
129MAPK40.36962032
130CAMKK10.36562434
131STK40.34814891
132MTOR0.33869075
133MAP2K10.33868541
134CLK10.33673639
135ACVR1B0.33655618
136EEF2K0.33533721

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005314.20630087
2* Lysosome_Homo sapiens_hsa041423.63434898
3ECM-receptor interaction_Homo sapiens_hsa045123.27670862
4Other glycan degradation_Homo sapiens_hsa005112.60895800
5Phagosome_Homo sapiens_hsa041452.56185356
6Malaria_Homo sapiens_hsa051442.55741101
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.41088036
8* Rheumatoid arthritis_Homo sapiens_hsa053232.35258179
9Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.35023863
10Amoebiasis_Homo sapiens_hsa051462.01387588
11Sphingolipid metabolism_Homo sapiens_hsa006001.93264636
12Focal adhesion_Homo sapiens_hsa045101.88431983
13Complement and coagulation cascades_Homo sapiens_hsa046101.86831567
14Protein digestion and absorption_Homo sapiens_hsa049741.78188655
15Staphylococcus aureus infection_Homo sapiens_hsa051501.66879153
16Tuberculosis_Homo sapiens_hsa051521.63599414
17Vibrio cholerae infection_Homo sapiens_hsa051101.58923669
18* Osteoclast differentiation_Homo sapiens_hsa043801.57377723
19AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.53747248
20Leishmaniasis_Homo sapiens_hsa051401.53021650
21Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.51796551
22Proteoglycans in cancer_Homo sapiens_hsa052051.43028410
23Pertussis_Homo sapiens_hsa051331.39168737
24Arachidonic acid metabolism_Homo sapiens_hsa005901.26991586
25Glutathione metabolism_Homo sapiens_hsa004801.24279564
26Steroid biosynthesis_Homo sapiens_hsa001001.24115285
27Collecting duct acid secretion_Homo sapiens_hsa049661.24010091
28Histidine metabolism_Homo sapiens_hsa003401.20261906
29Salmonella infection_Homo sapiens_hsa051321.19225561
30Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.16651400
31Caffeine metabolism_Homo sapiens_hsa002321.13434154
32* Toll-like receptor signaling pathway_Homo sapiens_hsa046201.12297713
33Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.08319057
34Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08274639
35PI3K-Akt signaling pathway_Homo sapiens_hsa041511.07405129
36Dilated cardiomyopathy_Homo sapiens_hsa054141.03937070
37Ether lipid metabolism_Homo sapiens_hsa005650.99670744
38Primary bile acid biosynthesis_Homo sapiens_hsa001200.99253216
39Legionellosis_Homo sapiens_hsa051340.95002011
40Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92345719
41Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91402821
42TGF-beta signaling pathway_Homo sapiens_hsa043500.90477145
43Arginine and proline metabolism_Homo sapiens_hsa003300.88602150
44Hematopoietic cell lineage_Homo sapiens_hsa046400.88040174
45Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.87822369
46SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87172126
47TNF signaling pathway_Homo sapiens_hsa046680.86516006
48Fatty acid elongation_Homo sapiens_hsa000620.85362439
49Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85295600
50Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.84904297
51Prion diseases_Homo sapiens_hsa050200.84806579
52Leukocyte transendothelial migration_Homo sapiens_hsa046700.83765195
53NF-kappa B signaling pathway_Homo sapiens_hsa040640.82532822
54Asthma_Homo sapiens_hsa053100.81661266
55Platelet activation_Homo sapiens_hsa046110.81406130
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81260332
57Galactose metabolism_Homo sapiens_hsa000520.78859948
58Toxoplasmosis_Homo sapiens_hsa051450.77195473
59Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.76986181
60* Apoptosis_Homo sapiens_hsa042100.74652269
61Renin-angiotensin system_Homo sapiens_hsa046140.74303788
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73939390
63Renal cell carcinoma_Homo sapiens_hsa052110.73613638
64Systemic lupus erythematosus_Homo sapiens_hsa053220.72297724
65Ras signaling pathway_Homo sapiens_hsa040140.71916526
66Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68822292
67African trypanosomiasis_Homo sapiens_hsa051430.68688958
68Prolactin signaling pathway_Homo sapiens_hsa049170.68251600
69Graft-versus-host disease_Homo sapiens_hsa053320.67360656
70Jak-STAT signaling pathway_Homo sapiens_hsa046300.67313439
71Hepatitis C_Homo sapiens_hsa051600.66955676
72Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.65932609
73Influenza A_Homo sapiens_hsa051640.65759784
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.65523613
75Sulfur metabolism_Homo sapiens_hsa009200.64364242
76Viral myocarditis_Homo sapiens_hsa054160.64132201
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.63604293
78Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.62236901
79Endocytosis_Homo sapiens_hsa041440.61918841
80Thyroid hormone synthesis_Homo sapiens_hsa049180.61386339
81HIF-1 signaling pathway_Homo sapiens_hsa040660.61339834
82Autoimmune thyroid disease_Homo sapiens_hsa053200.60190565
83MicroRNAs in cancer_Homo sapiens_hsa052060.60046394
84Shigellosis_Homo sapiens_hsa051310.59286928
85Linoleic acid metabolism_Homo sapiens_hsa005910.59086442
86Pentose and glucuronate interconversions_Homo sapiens_hsa000400.58185399
87Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.57586649
88Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.56745010
89RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55377366
90Mineral absorption_Homo sapiens_hsa049780.54852094
91GnRH signaling pathway_Homo sapiens_hsa049120.52515644
92Chronic myeloid leukemia_Homo sapiens_hsa052200.47866843
93Pancreatic cancer_Homo sapiens_hsa052120.47131415
94Melanoma_Homo sapiens_hsa052180.46554793
95Chemokine signaling pathway_Homo sapiens_hsa040620.46500670
96Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.46212622
97Starch and sucrose metabolism_Homo sapiens_hsa005000.45327024
98PPAR signaling pathway_Homo sapiens_hsa033200.45056628
99Neurotrophin signaling pathway_Homo sapiens_hsa047220.44401758
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.43830368
101Melanogenesis_Homo sapiens_hsa049160.43762948
102Rap1 signaling pathway_Homo sapiens_hsa040150.42846989
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.42779051
104Measles_Homo sapiens_hsa051620.42174682
105Gap junction_Homo sapiens_hsa045400.41613907
106Intestinal immune network for IgA production_Homo sapiens_hsa046720.41250595
107Small cell lung cancer_Homo sapiens_hsa052220.40887743
108Central carbon metabolism in cancer_Homo sapiens_hsa052300.40880701
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.40751332
110cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40527750
111Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.39351817
112Protein export_Homo sapiens_hsa030600.38579440
113Ovarian steroidogenesis_Homo sapiens_hsa049130.38051856
114Adherens junction_Homo sapiens_hsa045200.37330457
115Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.37075983
116Pathways in cancer_Homo sapiens_hsa052000.36881640
117Hepatitis B_Homo sapiens_hsa051610.35171532
118Prostate cancer_Homo sapiens_hsa052150.32754972
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.32545339
120Antigen processing and presentation_Homo sapiens_hsa046120.32482186
121Bladder cancer_Homo sapiens_hsa052190.31386565
122VEGF signaling pathway_Homo sapiens_hsa043700.30945800
123Allograft rejection_Homo sapiens_hsa053300.24992300

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