CTSL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysosomal cysteine proteinase that plays a major role in intracellular protein catabolism. Its substrates include collagen and elastin, as well as alpha-1 protease inhibitor, a major controlling element of neutrophil elastase activity. The encoded protein has been implicated in several pathologic processes, including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. This protein, which is a member of the peptidase C1 family, is a dimer composed of disulfide-linked heavy and light chains, both produced from a single protein precursor. Multiple alternatively spliced transcript variants have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glycosphingolipid catabolic process (GO:0046479)5.55631485
2oligosaccharide catabolic process (GO:0009313)5.26018885
3glycolipid catabolic process (GO:0019377)4.98816201
4negative regulation of interleukin-12 production (GO:0032695)4.56467755
5ceramide catabolic process (GO:0046514)4.41864833
6low-density lipoprotein particle clearance (GO:0034383)4.25631459
7peptidyl-glutamic acid carboxylation (GO:0017187)4.23167103
8protein carboxylation (GO:0018214)4.23167103
9amino sugar catabolic process (GO:0046348)4.22882091
10response to peptidoglycan (GO:0032494)4.22133288
11regulation of macrophage chemotaxis (GO:0010758)4.14631954
12apoptotic cell clearance (GO:0043277)4.03266452
13membrane lipid catabolic process (GO:0046466)4.01598406
14regulation of vitamin D biosynthetic process (GO:0060556)3.95738214
15positive regulation of monocyte chemotaxis (GO:0090026)3.95692262
16* cellular response to thyroid hormone stimulus (GO:0097067)3.88275848
17lipopolysaccharide-mediated signaling pathway (GO:0031663)3.87690354
18positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.85643376
19sphingolipid catabolic process (GO:0030149)3.80986038
20plasma lipoprotein particle clearance (GO:0034381)3.77923282
21eosinophil chemotaxis (GO:0048245)3.75940642
22cell adhesion mediated by integrin (GO:0033627)3.73490589
23regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.72479800
24negative regulation of fibrinolysis (GO:0051918)3.70948720
25positive regulation of chemokine biosynthetic process (GO:0045080)3.69715499
26protein localization to endosome (GO:0036010)3.67899844
27barbed-end actin filament capping (GO:0051016)3.66220074
28regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.59942168
29negative regulation of nitric oxide biosynthetic process (GO:0045019)3.54263047
30cellular response to arsenic-containing substance (GO:0071243)3.52855611
31adhesion of symbiont to host (GO:0044406)3.51516450
32virion attachment to host cell (GO:0019062)3.50835512
33adhesion of symbiont to host cell (GO:0044650)3.50835512
34regulation of cholesterol storage (GO:0010885)3.48514889
35basement membrane organization (GO:0071711)3.46641188
36monocyte chemotaxis (GO:0002548)3.46256588
37regulation of protein activation cascade (GO:2000257)3.46187192
38fibrinolysis (GO:0042730)3.44743111
39triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.44677804
40N-acetylneuraminate metabolic process (GO:0006054)3.44630035
41positive regulation of cholesterol efflux (GO:0010875)3.43113196
42regulation of monocyte chemotaxis (GO:0090025)3.41701553
43regulation of complement activation (GO:0030449)3.41038778
44L-phenylalanine catabolic process (GO:0006559)3.36812429
45erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.36812429
46eosinophil migration (GO:0072677)3.31350074
47detection of molecule of bacterial origin (GO:0032490)3.31235287
48neutrophil activation involved in immune response (GO:0002283)3.30626485
49erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.30128299
50L-phenylalanine metabolic process (GO:0006558)3.30128299
51reverse cholesterol transport (GO:0043691)3.27807177
52T-helper 1 type immune response (GO:0042088)3.23556138
53positive regulation of cellular amide metabolic process (GO:0034250)3.22348963
54* response to thyroid hormone (GO:0097066)3.20249639
55cysteine metabolic process (GO:0006534)3.20164395
56regulation of podosome assembly (GO:0071801)3.19897020
57regulation of vitamin metabolic process (GO:0030656)3.19469438
58sulfur amino acid catabolic process (GO:0000098)3.11991561
59regulation of cytokine secretion involved in immune response (GO:0002739)3.10304393
60positive regulation of hemostasis (GO:1900048)3.08984219
61positive regulation of blood coagulation (GO:0030194)3.08984219
62fat-soluble vitamin biosynthetic process (GO:0042362)3.08883649
63macrophage activation involved in immune response (GO:0002281)3.06145953
64positive regulation of leukocyte degranulation (GO:0043302)3.06145089
65complement activation, alternative pathway (GO:0006957)3.05814825
66decidualization (GO:0046697)3.05765016
67regulation of chemokine biosynthetic process (GO:0045073)3.05539239
68regulation of fibrinolysis (GO:0051917)3.04370934
69alpha-linolenic acid metabolic process (GO:0036109)3.02183870
70negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.00718855
71phagosome maturation (GO:0090382)2.98199937
72positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.97150070
73glial cell migration (GO:0008347)2.96391763
74iron ion import (GO:0097286)2.96341947
75pinocytosis (GO:0006907)2.92367090
76high-density lipoprotein particle remodeling (GO:0034375)2.90873232
77positive regulation of coagulation (GO:0050820)2.90565328
78positive regulation of cholesterol transport (GO:0032376)2.90203314
79positive regulation of sterol transport (GO:0032373)2.90203314
80myeloid dendritic cell differentiation (GO:0043011)2.88323210
81cellular response to cadmium ion (GO:0071276)2.88190539
82positive regulation vascular endothelial growth factor production (GO:0010575)2.87356528
83positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.85622900
84glyoxylate metabolic process (GO:0046487)2.83305099
85lipoprotein metabolic process (GO:0042157)2.83099568
86wound healing, spreading of epidermal cells (GO:0035313)2.80981200
87aldehyde catabolic process (GO:0046185)2.80976816
88hyaluronan catabolic process (GO:0030214)2.80197902
89vitamin transmembrane transport (GO:0035461)2.77017731
90cellular response to lipopolysaccharide (GO:0071222)2.76349441
91folic acid transport (GO:0015884)2.75975618
92homocysteine metabolic process (GO:0050667)2.74549344
93cellular response to zinc ion (GO:0071294)2.74449629
94endodermal cell differentiation (GO:0035987)2.72587088
95cellular response to interferon-alpha (GO:0035457)2.72511710
96intracellular pH reduction (GO:0051452)2.71837749
97NIK/NF-kappaB signaling (GO:0038061)2.70912535
98cholesterol efflux (GO:0033344)2.70235642
99lymphangiogenesis (GO:0001946)2.70036712
100regulation of early endosome to late endosome transport (GO:2000641)2.69987775
101negative regulation of myeloid cell apoptotic process (GO:0033033)2.69700069
102sphingosine metabolic process (GO:0006670)2.69173050
103skin morphogenesis (GO:0043589)2.68211962
104regulation of membrane protein ectodomain proteolysis (GO:0051043)2.67426933
105positive regulation of extracellular matrix organization (GO:1903055)2.67097468
106cellular response to molecule of bacterial origin (GO:0071219)2.65105269
107positive regulation of leukocyte chemotaxis (GO:0002690)2.64431298
108regulation of mast cell degranulation (GO:0043304)2.64334056
109vitamin D metabolic process (GO:0042359)2.62174793
110pH reduction (GO:0045851)2.62072104
111phospholipid efflux (GO:0033700)2.61595247
112regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.61308395
113plasma lipoprotein particle remodeling (GO:0034369)2.61307300
114protein-lipid complex remodeling (GO:0034368)2.61307300
115macromolecular complex remodeling (GO:0034367)2.61307300
116wound healing, spreading of cells (GO:0044319)2.61274195
1174-hydroxyproline metabolic process (GO:0019471)2.60924617
118keratan sulfate catabolic process (GO:0042340)2.60484287
119aromatic amino acid family catabolic process (GO:0009074)2.59968707
120phospholipid homeostasis (GO:0055091)2.59382866
121interleukin-6-mediated signaling pathway (GO:0070102)2.59347432
122regulation of superoxide anion generation (GO:0032928)2.59066103
123protein-lipid complex assembly (GO:0065005)2.57980709
124serine family amino acid catabolic process (GO:0009071)2.57898250
125macrophage differentiation (GO:0030225)2.55947510
126positive regulation of p38MAPK cascade (GO:1900745)2.55667739
127regulation of vascular endothelial growth factor production (GO:0010574)2.54987902
128cellular extravasation (GO:0045123)2.54351044
129epoxygenase P450 pathway (GO:0019373)2.53547373
130regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.53141326
131response to lipoprotein particle (GO:0055094)2.52901109
132positive regulation of leukocyte migration (GO:0002687)2.52241138
133immunoglobulin mediated immune response (GO:0016064)2.52113482
134positive regulation of triglyceride lipase activity (GO:0061365)2.52022818
135positive regulation of lipoprotein lipase activity (GO:0051006)2.52022818
136cellular response to vitamin (GO:0071295)2.51784962
137negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.51222185
138regulation of nitric oxide biosynthetic process (GO:0045428)2.50940922
139transferrin transport (GO:0033572)2.50760825
140positive regulation of heat generation (GO:0031652)2.50719949
141response to progesterone (GO:0032570)2.50584703
142osteoclast differentiation (GO:0030316)2.50225238
143negative regulation of protein activation cascade (GO:2000258)2.50155161
144low-density lipoprotein particle remodeling (GO:0034374)2.49860157
145lytic vacuole organization (GO:0080171)2.49715448
146lysosome organization (GO:0007040)2.49715448
147retina vasculature morphogenesis in camera-type eye (GO:0061299)2.48127391
148negative regulation of blood coagulation (GO:0030195)2.47899635
149negative regulation of hemostasis (GO:1900047)2.47899635
150negative regulation of coagulation (GO:0050819)2.47834882
151bile acid biosynthetic process (GO:0006699)2.47411397
152hemidesmosome assembly (GO:0031581)2.46300039
153vascular endothelial growth factor signaling pathway (GO:0038084)2.45781191
154cholesterol transport (GO:0030301)2.45385174
155sterol transport (GO:0015918)2.45385174
156opsonization (GO:0008228)2.44934105
157xenobiotic catabolic process (GO:0042178)2.44643111
158urea cycle (GO:0000050)2.44447251
159urea metabolic process (GO:0019627)2.44447251
160transcytosis (GO:0045056)2.43940915
161regulation of integrin-mediated signaling pathway (GO:2001044)2.43345568
162glomerular basement membrane development (GO:0032836)2.42822989
163regulation of mononuclear cell migration (GO:0071675)2.41899058
164* extracellular matrix disassembly (GO:0022617)2.39770354
165* collagen metabolic process (GO:0032963)2.39383513
166L-ascorbic acid metabolic process (GO:0019852)2.39051538
167sexual reproduction (GO:0019953)2.38200463
168sterol homeostasis (GO:0055092)2.37956567
169triglyceride homeostasis (GO:0070328)2.37937196
170acylglycerol homeostasis (GO:0055090)2.37937196
171response to nitrosative stress (GO:0051409)2.37772878
172negative regulation of lipid storage (GO:0010888)2.36771694
173protein-lipid complex subunit organization (GO:0071825)2.36465674
174modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.36286151
175positive regulation by organism of defense response of other organism involved in symbiotic interact2.36286151
176modulation by symbiont of host immune response (GO:0052553)2.36286151
177positive regulation by symbiont of host defense response (GO:0052509)2.36286151
178modulation by symbiont of host defense response (GO:0052031)2.36286151
179modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.36286151
180COPI coating of Golgi vesicle (GO:0048205)2.35917890

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse5.74786711
2RXR_22158963_ChIP-Seq_LIVER_Mouse4.25076631
3TP63_17297297_ChIP-ChIP_HaCaT_Human3.91724294
4CLOCK_20551151_ChIP-Seq_293T_Human3.91066653
5TRIM28_21343339_ChIP-Seq_HEK293_Human3.75930154
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.71851964
7PPARA_22158963_ChIP-Seq_LIVER_Mouse3.67724040
8LXR_22158963_ChIP-Seq_LIVER_Mouse3.57513018
9TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.51643658
10RARG_19884340_ChIP-ChIP_MEFs_Mouse3.49473380
11FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.52119830
12NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.45745740
13Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.43432284
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.41473620
15* EGR1_23403033_ChIP-Seq_LIVER_Mouse2.36517863
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.31670493
17SALL4_18804426_ChIP-ChIP_XEN_Mouse2.26741609
18TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.22048151
19TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.14866370
20ESR2_21235772_ChIP-Seq_MCF-7_Human2.13545032
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.12378523
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.12197820
23* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.11219867
24SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.09913913
25VDR_24787735_ChIP-Seq_THP-1_Human2.05798818
26* CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.02586890
27STAT4_19710469_ChIP-ChIP_TH1__Mouse1.95495702
28RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.94055509
29PPAR_26484153_Chip-Seq_NCI-H1993_Human1.88972200
30NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.87658737
31STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.84406593
32STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.84195818
33IRF8_21731497_ChIP-ChIP_J774_Mouse1.83140160
34NRF2_20460467_ChIP-Seq_MEFs_Mouse1.82311689
35NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.82311689
36SPI1_23127762_ChIP-Seq_K562_Human1.80130543
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.79427699
38NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.78319810
39SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.77040949
40* SOX2_20726797_ChIP-Seq_SW620_Human1.72782961
41GATA1_22025678_ChIP-Seq_K562_Human1.69906589
42FOXO3_23340844_ChIP-Seq_DLD1_Human1.69448657
43CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.67763254
44CJUN_26792858_Chip-Seq_BT549_Human1.64976477
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64815054
46HIF1A_21447827_ChIP-Seq_MCF-7_Human1.61547628
47STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.60596451
48VDR_24763502_ChIP-Seq_THP-1_Human1.59647475
49NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57946747
50SPI1_23547873_ChIP-Seq_NB4_Human1.56011944
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.55082275
52NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.54613690
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.51850087
54RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.51842456
55RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.50957399
56STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50212007
57LXR_22292898_ChIP-Seq_THP-1_Human1.50205415
58* IRF8_27001747_Chip-Seq_BMDM_Mouse1.48921548
59SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.47351881
60SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.47351881
61PU_27001747_Chip-Seq_BMDM_Mouse1.45581167
62CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.42882440
63GATA2_21666600_ChIP-Seq_HMVEC_Human1.41911852
64* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.40254812
65NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.38836476
66KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36945774
67KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36945774
68KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36945774
69SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.35700265
70EGR1_19374776_ChIP-ChIP_THP-1_Human1.35573735
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.35483120
72* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.34520999
73ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.32135717
74ELK3_25401928_ChIP-Seq_HUVEC_Human1.30354848
75MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.30298740
76ATF3_27146783_Chip-Seq_COLON_Human1.29918339
77VDR_21846776_ChIP-Seq_THP-1_Human1.29819222
78IRF8_22096565_ChIP-ChIP_GC-B_Human1.27649689
79HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.27041305
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.26410353
81GATA4_25053715_ChIP-Seq_YYC3_Human1.25565704
82* RUNX1_22412390_ChIP-Seq_EML_Mouse1.24425859
83JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.24126729
84BP1_19119308_ChIP-ChIP_Hs578T_Human1.23882445
85POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.23148478
86UBF1/2_26484160_Chip-Seq_HMECs_Human1.22652862
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22377541
88PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.18534969
89JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.18448935
90RACK7_27058665_Chip-Seq_MCF-7_Human1.17776096
91CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17527393
92CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17411169
93SMAD_19615063_ChIP-ChIP_OVARY_Human1.17394325
94EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.16979150
95P63_26484246_Chip-Seq_KERATINOCYTES_Human1.16963100
96SOX2_27498859_Chip-Seq_STOMACH_Mouse1.16658911
97SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.15727768
98PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14424643
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14049911
100GATA1_19941826_ChIP-Seq_K562_Human1.13875634
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12167082
102TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.11998954
103ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.10547529
104P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10500891
105WT1_19549856_ChIP-ChIP_CCG9911_Human1.10018325
106KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07851006
107ZNF263_19887448_ChIP-Seq_K562_Human1.07734113
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.07351296
109FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06768491
110FOXA2_19822575_ChIP-Seq_HepG2_Human1.06516828
111STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.06040448
112THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05344709
113BRD4_25478319_ChIP-Seq_HGPS_Human1.04898799
114CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04889113
115LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03982369
116FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.02728431
117NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01762062
118TFEB_21752829_ChIP-Seq_HELA_Human0.98059662
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.97135184
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.96743538
121MYB_21317192_ChIP-Seq_ERMYB_Mouse0.96440193
122TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.96227978
123FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.96045143
124* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.96014068
125EP300_21415370_ChIP-Seq_HL-1_Mouse0.95700652
126HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95485329
127ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.93508708
128GATA3_24758297_ChIP-Seq_MCF-7_Human0.92375485
129STAT1_20625510_ChIP-Seq_HELA_Human0.90959052
130PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.90279165
131* GATA1_19941827_ChIP-Seq_MEL_Mouse0.89941555
132AR_21909140_ChIP-Seq_LNCAP_Human0.89895128
133SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.89803778
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.88717462
135VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.88365775
136* SOX17_20123909_ChIP-Seq_XEN_Mouse0.87332122
137GATA1_22383799_ChIP-Seq_G1ME_Mouse0.86785465
138BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.85862114
139GATA6_25053715_ChIP-Seq_YYC3_Human0.85074707
140PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84554045
141FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.82860083
142SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.80688390
143BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76943828

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.81387011
2MP0005058_abnormal_lysosome_morphology3.45106606
3MP0009840_abnormal_foam_cell3.17663824
4MP0003195_calcinosis3.03267693
5MP0002139_abnormal_hepatobiliary_system3.01565235
6MP0004272_abnormal_basement_membrane2.95996396
7MP0003705_abnormal_hypodermis_morpholog2.93119217
8MP0002148_abnormal_hypersensitivity_rea2.86300850
9MP0005360_urolithiasis2.67529710
10MP0005275_abnormal_skin_tensile2.52031101
11MP0003191_abnormal_cellular_cholesterol2.51945780
12MP0004510_myositis2.44143142
13MP0009785_altered_susceptibility_to2.37133424
14MP0005365_abnormal_bile_salt2.25047870
15MP0006054_spinal_hemorrhage2.23398066
16MP0003075_altered_response_to2.17734707
17MP0010368_abnormal_lymphatic_system2.07734975
18MP0005257_abnormal_intraocular_pressure2.02634125
19MP0002254_reproductive_system_inflammat1.98996919
20MP0001853_heart_inflammation1.90421994
21MP0005085_abnormal_gallbladder_physiolo1.89593292
22MP0003329_amyloid_beta_deposits1.87802392
23MP0002877_abnormal_melanocyte_morpholog1.83033180
24MP0001835_abnormal_antigen_presentation1.81339920
25MP0010329_abnormal_lipoprotein_level1.80275903
26MP0005503_abnormal_tendon_morphology1.74870652
27MP0003566_abnormal_cell_adhesion1.73504218
28MP0005167_abnormal_blood-brain_barrier1.72400318
29MP0005025_abnormal_response_to1.71414204
30MP0009384_cardiac_valve_regurgitation1.69935512
31MP0003690_abnormal_glial_cell1.68720800
32MP0001661_extended_life_span1.67962825
33MP0008875_abnormal_xenobiotic_pharmacok1.66124282
34MP0001790_abnormal_immune_system1.64506343
35MP0005387_immune_system_phenotype1.64506343
36MP0001958_emphysema1.64327327
37* MP0005000_abnormal_immune_tolerance1.64309094
38MP0000604_amyloidosis1.63215377
39MP0005023_abnormal_wound_healing1.62913982
40MP0003806_abnormal_nucleotide_metabolis1.60356629
41MP0003300_gastrointestinal_ulcer1.50458354
42MP0003724_increased_susceptibility_to1.50032981
43MP0005623_abnormal_meninges_morphology1.49202052
44MP0000013_abnormal_adipose_tissue1.48767149
45MP0005083_abnormal_biliary_tract1.48004491
46MP0005332_abnormal_amino_acid1.47499230
47MP0002295_abnormal_pulmonary_circulatio1.46756257
48MP0004019_abnormal_vitamin_homeostasis1.46431359
49* MP0002452_abnormal_antigen_presenting1.43996960
50MP0005671_abnormal_response_to1.43800012
51MP0001542_abnormal_bone_strength1.43704959
52MP0003252_abnormal_bile_duct1.42494639
53MP0000685_abnormal_immune_system1.41512894
54MP0003279_aneurysm1.38790200
55MP0006082_CNS_inflammation1.37994646
56MP0003172_abnormal_lysosome_physiology1.36618528
57MP0005464_abnormal_platelet_physiology1.34291474
58* MP0001845_abnormal_inflammatory_respons1.33758040
59MP0000920_abnormal_myelination1.30935371
60MP0005397_hematopoietic_system_phenotyp1.26087168
61MP0001545_abnormal_hematopoietic_system1.26087168
62MP0002723_abnormal_immune_serum1.25476548
63MP0002060_abnormal_skin_morphology1.22586168
64MP0000343_altered_response_to1.22552700
65MP0001533_abnormal_skeleton_physiology1.21894239
66* MP0000609_abnormal_liver_physiology1.20689588
67MP0005164_abnormal_response_to1.20672386
68MP0002168_other_aberrant_phenotype1.20600907
69MP0008260_abnormal_autophagy1.20461449
70MP0003091_abnormal_cell_migration1.20292931
71MP0005166_decreased_susceptibility_to1.18953914
72MP0004185_abnormal_adipocyte_glucose1.18846664
73MP0002405_respiratory_system_inflammati1.17195857
74MP0005508_abnormal_skeleton_morphology1.12825982
75MP0001879_abnormal_lymphatic_vessel1.11722532
76MP0003828_pulmonary_edema1.10143140
77MP0000371_diluted_coat_color1.10006460
78MP0003186_abnormal_redox_activity1.10001715
79* MP0004947_skin_inflammation1.08293641
80MP0002118_abnormal_lipid_homeostasis1.08152301
81MP0001666_abnormal_nutrient_absorption1.07847281
82MP0005451_abnormal_body_composition1.07138086
83MP0009643_abnormal_urine_homeostasis1.04412499
84MP0005319_abnormal_enzyme/_coenzyme1.04159316
85MP0005165_increased_susceptibility_to1.04083458
86MP0003303_peritoneal_inflammation1.03611738
87MP0001756_abnormal_urination1.03245962
88MP0001915_intracranial_hemorrhage1.02629138
89MP0005595_abnormal_vascular_smooth1.02004857
90MP0005408_hypopigmentation1.01498398
91MP0009333_abnormal_splenocyte_physiolog1.01028373
92MP0002896_abnormal_bone_mineralization1.00930726
93MP0001851_eye_inflammation0.99608219
94MP0004130_abnormal_muscle_cell0.98595721
95* MP0001819_abnormal_immune_cell0.96763256
96* MP0002420_abnormal_adaptive_immunity0.96187931
97MP0003436_decreased_susceptibility_to0.93217197
98MP0008004_abnormal_stomach_pH0.93082060
99MP0000733_abnormal_muscle_development0.92891910
100MP0000598_abnormal_liver_morphology0.92238398
101MP0005395_other_phenotype0.91879795
102MP0005390_skeleton_phenotype0.91768597
103MP0001800_abnormal_humoral_immune0.91018050
104MP0003634_abnormal_glial_cell0.90907891
105MP0004233_abnormal_muscle_weight0.89341967
106MP0000003_abnormal_adipose_tissue0.89296346
107MP0009053_abnormal_anal_canal0.88991705
108* MP0003453_abnormal_keratinocyte_physiol0.88804219
109MP0000767_abnormal_smooth_muscle0.88499457
110MP0009278_abnormal_bone_marrow0.88033646
111* MP0003795_abnormal_bone_structure0.86281420
112MP0010155_abnormal_intestine_physiology0.85585591
113MP0010307_abnormal_tumor_latency0.83869779
114MP0004883_abnormal_blood_vessel0.81081330
115MP0009763_increased_sensitivity_to0.80989270
116MP0010234_abnormal_vibrissa_follicle0.80415848
117MP0005197_abnormal_uvea_morphology0.79625946
118MP0003448_altered_tumor_morphology0.78335241
119* MP0002998_abnormal_bone_remodeling0.78198081
120MP0002332_abnormal_exercise_endurance0.77819539
121MP0001849_ear_inflammation0.77486540
122MP0009764_decreased_sensitivity_to0.77302074
123MP0005375_adipose_tissue_phenotype0.76976957
124MP0002837_dystrophic_cardiac_calcinosis0.76337721
125MP0000249_abnormal_blood_vessel0.75847314
126MP0005647_abnormal_sex_gland0.75524216
127MP0003221_abnormal_cardiomyocyte_apopto0.74290769
128MP0002090_abnormal_vision0.74142284
129MP0002796_impaired_skin_barrier0.74012112
130MP0008469_abnormal_protein_level0.73671509
131MP0005670_abnormal_white_adipose0.72807388
132MP0000750_abnormal_muscle_regeneration0.72756986
133MP0005666_abnormal_adipose_tissue0.72046864
134MP0005367_renal/urinary_system_phenotyp0.71917452
135MP0000516_abnormal_urinary_system0.71917452
136MP0002136_abnormal_kidney_physiology0.71367635
137MP0000858_altered_metastatic_potential0.71344714
138MP0003656_abnormal_erythrocyte_physiolo0.71121349
139MP0001881_abnormal_mammary_gland0.70058892
140MP0003045_fibrosis0.69744411
141* MP0002419_abnormal_innate_immunity0.69146064
142MP0003950_abnormal_plasma_membrane0.68592068
143* MP0001243_abnormal_dermal_layer0.68404640
144* MP0005310_abnormal_salivary_gland0.66793493
145MP0005584_abnormal_enzyme/coenzyme_acti0.62193330
146MP0000747_muscle_weakness0.60347271
147MP0008874_decreased_physiological_sensi0.58724801
148MP0003632_abnormal_nervous_system0.58649484

Predicted human phenotypes

RankGene SetZ-score
1Premature rupture of membranes (HP:0001788)5.04389941
2Neurofibrillary tangles (HP:0002185)4.74482655
3Abnormality of macrophages (HP:0004311)4.51425233
4Deep venous thrombosis (HP:0002625)4.29473472
5Increased cerebral lipofuscin (HP:0011813)4.03557670
6Disinhibition (HP:0000734)4.00460738
7Protrusio acetabuli (HP:0003179)3.99165451
8Xanthomatosis (HP:0000991)3.72891623
9Nuclear cataract (HP:0100018)3.63262151
10Mutism (HP:0002300)3.58269938
11Vacuolated lymphocytes (HP:0001922)3.55859445
12Systemic lupus erythematosus (HP:0002725)3.52760774
13Myocardial infarction (HP:0001658)3.50226900
14Cerebral inclusion bodies (HP:0100314)3.47645477
15Increased neuronal autofluorescent lipopigment (HP:0002074)3.47204939
16Dysostosis multiplex (HP:0000943)3.44340429
17Complement deficiency (HP:0004431)3.35355987
18Recurrent bacterial skin infections (HP:0005406)3.33447266
19Eczematoid dermatitis (HP:0000976)3.30247698
20Recurrent abscess formation (HP:0002722)3.21311287
21Osteolytic defects of the hand bones (HP:0009699)3.20245543
22Osteolytic defects of the phalanges of the hand (HP:0009771)3.20245543
23Abnormality of glycolipid metabolism (HP:0010969)3.10902054
24Abnormality of liposaccharide metabolism (HP:0010968)3.10902054
25Abnormality of glycosphingolipid metabolism (HP:0004343)3.10902054
26Nonimmune hydrops fetalis (HP:0001790)3.09928363
27Cerebral aneurysm (HP:0004944)3.07316068
28Ankle contracture (HP:0006466)3.05341203
29Cervical subluxation (HP:0003308)3.03019793
30Hyperlipoproteinemia (HP:0010980)2.98612708
31Vertebral compression fractures (HP:0002953)2.98571945
32Axonal loss (HP:0003447)2.94022179
33Urinary glycosaminoglycan excretion (HP:0003541)2.93214085
34Mucopolysacchariduria (HP:0008155)2.93214085
35Glomerulonephritis (HP:0000099)2.90040040
36Intrahepatic cholestasis (HP:0001406)2.84741277
37Autoimmune thrombocytopenia (HP:0001973)2.84217261
38Abnormality of monocarboxylic acid metabolism (HP:0010996)2.83942273
39Apathy (HP:0000741)2.82353750
40Abnormality of aromatic amino acid family metabolism (HP:0004338)2.81433751
41Diminished motivation (HP:0000745)2.79798690
42Hypoalphalipoproteinemia (HP:0003233)2.79082088
43Abnormality of complement system (HP:0005339)2.69365184
44Abnormality of polysaccharide metabolism (HP:0011012)2.68651449
45Abnormality of glycosaminoglycan metabolism (HP:0004371)2.68651449
46Abnormality of mucopolysaccharide metabolism (HP:0011020)2.68651449
47Progressive neurologic deterioration (HP:0002344)2.62998608
48Metaphyseal irregularity (HP:0003025)2.61830889
49Nephritis (HP:0000123)2.58729801
50Upper motor neuron abnormality (HP:0002127)2.57755994
51Neuronal loss in central nervous system (HP:0002529)2.57076498
52Peritonitis (HP:0002586)2.56016392
53Skin nodule (HP:0200036)2.55138359
54Prolonged neonatal jaundice (HP:0006579)2.53437851
55Aortic dissection (HP:0002647)2.51354613
56Abnormality of glutamine family amino acid metabolism (HP:0010902)2.51310007
57Abnormality of the intrinsic pathway (HP:0010989)2.50082589
58Purpura (HP:0000979)2.48287384
59Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.47656597
60Increased serum ferritin (HP:0003281)2.46100842
61Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.45974471
62Hydroxyprolinuria (HP:0003080)2.43883332
63Abnormality of proline metabolism (HP:0010907)2.43883332
64Soft skin (HP:0000977)2.43542563
65Cardiovascular calcification (HP:0011915)2.42621706
66Hypolipoproteinemia (HP:0010981)2.42590103
67Mediastinal lymphadenopathy (HP:0100721)2.42523476
68Alopecia of scalp (HP:0002293)2.38113326
69Abnormality of the common coagulation pathway (HP:0010990)2.37702789
70Blue sclerae (HP:0000592)2.37323771
71Thick nail (HP:0001805)2.36950044
72Hepatosplenomegaly (HP:0001433)2.36113634
73Broad metatarsal (HP:0001783)2.35053352
74Short nail (HP:0001799)2.34982596
75Joint hemorrhage (HP:0005261)2.31254087
76Atrophic scars (HP:0001075)2.30122302
77Aortic aneurysm (HP:0004942)2.24839291
78Shallow orbits (HP:0000586)2.24837698
79Esophageal varix (HP:0002040)2.24728744
80Vascular calcification (HP:0004934)2.24307423
81Conjunctival telangiectasia (HP:0000524)2.23752881
82Vascular tortuosity (HP:0004948)2.23034163
83Abnormality of the vasculature of the conjunctiva (HP:0008054)2.22531555
84Dementia (HP:0000726)2.21181374
85Prolonged partial thromboplastin time (HP:0003645)2.20789148
86Supranuclear gaze palsy (HP:0000605)2.17700480
87Hypobetalipoproteinemia (HP:0003563)2.17415970
88Arterial tortuosity (HP:0005116)2.16954287
89Agnosia (HP:0010524)2.12781262
90Ovoid vertebral bodies (HP:0003300)2.10913749
91Wormian bones (HP:0002645)2.10858761
92Nausea (HP:0002018)2.10375345
93Cardiomegaly (HP:0001640)2.07580220
94Global brain atrophy (HP:0002283)2.07493190
95Retinal atrophy (HP:0001105)2.07427217
96Abnormality of the periventricular white matter (HP:0002518)2.06678585
97Hyperglycinemia (HP:0002154)2.06607423
98Bone pain (HP:0002653)2.06246270
99Mitral stenosis (HP:0001718)2.05747954
100Inappropriate behavior (HP:0000719)2.04656892
101Lymphangioma (HP:0100764)2.01826699
102Peripheral demyelination (HP:0011096)2.00655456
103Abnormal delivery (HP:0001787)2.00544087
104Increased CSF protein (HP:0002922)2.00164447
105Orchitis (HP:0100796)1.99833142
106Hypercholesterolemia (HP:0003124)1.96804169
107Epidermoid cyst (HP:0200040)1.96600478
108Abnormal cartilage morphology (HP:0002763)1.94237301
109Fat malabsorption (HP:0002630)1.94053439
110Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.93913216
111Focal segmental glomerulosclerosis (HP:0000097)1.92985040
112Hypoglycemic coma (HP:0001325)1.92532622
113Protuberant abdomen (HP:0001538)1.90945599
114Tetraparesis (HP:0002273)1.90854693
115Beaking of vertebral bodies (HP:0004568)1.90237773
116Interstitial pulmonary disease (HP:0006530)1.90235353
117Hyperglycinuria (HP:0003108)1.89133313
118Abnormality of iron homeostasis (HP:0011031)1.88904048
119Hemorrhage of the eye (HP:0011885)1.87292264
120Abnormality of serine family amino acid metabolism (HP:0010894)1.86894664
121Abnormality of glycine metabolism (HP:0010895)1.86894664
122Right ventricular cardiomyopathy (HP:0011663)1.86800879
123Esophageal neoplasm (HP:0100751)1.85963134
124Neoplasm of head and neck (HP:0012288)1.85963134
125Spondylolisthesis (HP:0003302)1.84015714
126Loss of speech (HP:0002371)1.83628908
127Hematochezia (HP:0002573)1.83497787
128Personality changes (HP:0000751)1.82590606
129Aneurysm (HP:0002617)1.81312285
130Pathologic fracture (HP:0002756)1.81311286
131Malnutrition (HP:0004395)1.81180627
132Recurrent gram-negative bacterial infections (HP:0005420)1.80996697
133Gingivitis (HP:0000230)1.80690649
134Increased connective tissue (HP:0009025)1.80683795
135Turricephaly (HP:0000262)1.80663040
136Joint stiffness (HP:0001387)1.80618850
137Mesangial abnormality (HP:0001966)1.78480253
138Abnormality of sulfur amino acid metabolism (HP:0004339)1.77242871
139Follicular hyperkeratosis (HP:0007502)1.76655526
140Petechiae (HP:0000967)1.75522397
141Amyloidosis (HP:0011034)1.75271753
142Asymmetric septal hypertrophy (HP:0001670)1.74280856
143Hand muscle atrophy (HP:0009130)1.74278558
144J-shaped sella turcica (HP:0002680)1.74048868
145Retrobulbar optic neuritis (HP:0100654)1.72302334
146Optic neuritis (HP:0100653)1.72302334
147Obstructive lung disease (HP:0006536)1.70017702
148Chronic obstructive pulmonary disease (HP:0006510)1.70017702
149Achilles tendon contracture (HP:0001771)1.68886315
150Myositis (HP:0100614)1.68757816
151Recurrent skin infections (HP:0001581)1.66596947
152Thin bony cortex (HP:0002753)1.65350048
153Progressive visual loss (HP:0000529)1.62990900
154Albinism (HP:0001022)1.62023870
155Polyneuropathy (HP:0001271)1.61478124
156Thoracic kyphosis (HP:0002942)1.61128997
157Pulmonary infiltrates (HP:0002113)1.60803420
158Basal ganglia calcification (HP:0002135)1.59472338

Predicted kinase interactions (KEA)

RankGene SetZ-score
1KDR4.06442107
2ERN13.69664816
3GRK73.30871172
4TRIB33.13382689
5EPHB12.93949300
6MAP3K142.53172690
7TGFBR22.47866937
8EPHA22.33204016
9LATS12.31938267
10TAOK22.26440221
11MATK2.21506539
12NEK92.19927930
13ACVR1B2.17414172
14PKN22.06433167
15FGFR42.00505862
16PBK1.96705917
17LATS21.93868828
18MET1.93105682
19TTN1.89517945
20DDR21.84631219
21PDGFRA1.81678208
22FGR1.80716308
23SCYL21.69855385
24PTK61.67566053
25PTK21.62811369
26PRPF4B1.58052037
27FER1.57706831
28STK31.54636834
29CDC42BPA1.52344804
30MAP3K111.47614353
31RIPK11.45405402
32MAP3K31.45087519
33SIK11.43229723
34PAK41.39334108
35TIE11.37323511
36ERBB41.36786955
37ADRBK21.33477034
38PAK21.33273939
39EPHB21.31674992
40FRK1.30457379
41LIMK11.29883317
42MST1R1.29381373
43IKBKB1.27549871
44ABL21.27464482
45MAPK151.25840398
46JAK11.22964146
47BCKDK1.22845789
48ZAP701.20728924
49TBK11.17468732
50TAOK11.17187455
51EPHA31.17033760
52TYK21.16595029
53MAP2K21.13574952
54NME21.13060258
55LRRK21.12197389
56MAP2K11.11183748
57PIK3CG1.09122212
58MAP3K21.08256640
59IRAK41.08086756
60BMX1.07736389
61BMPR21.06393721
62MAP3K131.06185759
63CAMKK21.01674650
64STK390.99594913
65STK38L0.97116522
66PAK30.95421614
67MAP3K10.92513705
68MOS0.91663394
69TYRO30.90714939
70PDK20.90647071
71PIM20.90424788
72NTRK10.88612478
73PDGFRB0.85690367
74IKBKE0.82507998
75RIPK40.82223039
76WNK40.80812268
77GSK3A0.80668384
78BLK0.77881781
79CSK0.75888971
80KSR20.75667382
81TRPM70.74784417
82FGFR20.74645192
83TESK10.74166114
84RPS6KA40.73858568
85JAK20.73652230
86ARAF0.72567231
87STK100.72123821
88CHUK0.70678835
89CAMK1D0.70646104
90CLK10.69074435
91TESK20.68784213
92MTOR0.68642412
93CSNK1A1L0.68536348
94IRAK20.68080354
95FGFR10.67058548
96MARK30.66247874
97TGFBR10.64183526
98MAP2K30.61588080
99MAP3K50.61562231
100CSF1R0.59612535
101WNK30.59411251
102CDK60.57204459
103STK240.57004779
104EGFR0.54811072
105PTK2B0.54435989
106RET0.54225377
107CSNK1G10.53907961
108LYN0.53635901
109PRKG20.53281324
110CSNK1G30.50362788
111RPS6KC10.48317066
112RPS6KL10.48317066
113RPS6KA20.48237619
114ABL10.48195961
115BRSK20.46743282
116KIT0.46288050
117PDPK10.45273985
118PAK10.43501669
119FLT30.43200397
120IGF1R0.42772518
121MST40.42152403
122MAP3K80.40488573
123ICK0.39721779
124INSR0.39573499
125ERBB20.36429420
126ROCK10.36417667
127FGFR30.36411071
128MAPK40.36200905
129MYLK0.36062822
130JAK30.35791501
131MAP2K60.34286800
132CAMK2G0.33998530
133IRAK30.33978199
134IRAK10.32928866
135DAPK30.32257637
136PAK60.31778333
137RPS6KA60.31648774
138PRKD10.31317692
139EIF2AK30.30572784
140HCK0.26423390
141MAP3K120.25723035
142PRKD20.25535524
143LCK0.25084879
144DAPK20.22554122
145PRKCD0.22074416
146CAMK1G0.21510617

Predicted pathways (KEGG)

RankGene SetZ-score
1Complement and coagulation cascades_Homo sapiens_hsa046103.16267716
2Staphylococcus aureus infection_Homo sapiens_hsa051502.58618845
3* Lysosome_Homo sapiens_hsa041422.55135504
4Primary bile acid biosynthesis_Homo sapiens_hsa001202.48150813
5Steroid biosynthesis_Homo sapiens_hsa001002.31460022
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.28151148
7Nitrogen metabolism_Homo sapiens_hsa009102.27633957
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.27323722
9Vitamin B6 metabolism_Homo sapiens_hsa007502.18515431
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.10212124
11Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96404534
12Collecting duct acid secretion_Homo sapiens_hsa049661.87222970
13PPAR signaling pathway_Homo sapiens_hsa033201.86389888
14Pentose and glucuronate interconversions_Homo sapiens_hsa000401.85145287
15Fatty acid degradation_Homo sapiens_hsa000711.81605408
16Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.76848960
17Arginine biosynthesis_Homo sapiens_hsa002201.75220741
18Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.70525358
19Salmonella infection_Homo sapiens_hsa051321.67692244
20ECM-receptor interaction_Homo sapiens_hsa045121.65134769
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.64324587
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.63616093
23Vitamin digestion and absorption_Homo sapiens_hsa049771.58681066
24Fatty acid metabolism_Homo sapiens_hsa012121.58520627
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.54184299
26Asthma_Homo sapiens_hsa053101.53325783
27Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.53317770
28Caffeine metabolism_Homo sapiens_hsa002321.51055460
29Allograft rejection_Homo sapiens_hsa053301.47246685
30NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46910668
31Malaria_Homo sapiens_hsa051441.44874609
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.44430160
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.41284706
34Tryptophan metabolism_Homo sapiens_hsa003801.40791631
35Vibrio cholerae infection_Homo sapiens_hsa051101.40338071
36Other glycan degradation_Homo sapiens_hsa005111.38488127
37Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.37257345
38Chemical carcinogenesis_Homo sapiens_hsa052041.36779622
39Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.32087505
40Fatty acid elongation_Homo sapiens_hsa000621.30975869
41Histidine metabolism_Homo sapiens_hsa003401.27615957
42Graft-versus-host disease_Homo sapiens_hsa053321.26302786
43Folate biosynthesis_Homo sapiens_hsa007901.24466136
44Peroxisome_Homo sapiens_hsa041461.24069259
45Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.22462015
46Fat digestion and absorption_Homo sapiens_hsa049751.21382587
47Steroid hormone biosynthesis_Homo sapiens_hsa001401.17715923
48Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.14516228
49Autoimmune thyroid disease_Homo sapiens_hsa053201.12989856
50* Phagosome_Homo sapiens_hsa041451.09996264
51Glutathione metabolism_Homo sapiens_hsa004801.07566338
52Amoebiasis_Homo sapiens_hsa051461.06505268
53Butanoate metabolism_Homo sapiens_hsa006501.05947916
54Retinol metabolism_Homo sapiens_hsa008301.05877411
55Intestinal immune network for IgA production_Homo sapiens_hsa046721.05562923
56* Antigen processing and presentation_Homo sapiens_hsa046121.04202568
57Influenza A_Homo sapiens_hsa051641.04077283
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.03689987
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.02729309
60Shigellosis_Homo sapiens_hsa051311.01563055
61Hematopoietic cell lineage_Homo sapiens_hsa046400.99580582
62Starch and sucrose metabolism_Homo sapiens_hsa005000.97364662
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.96412251
64Type I diabetes mellitus_Homo sapiens_hsa049400.95697150
65Propanoate metabolism_Homo sapiens_hsa006400.95358838
66beta-Alanine metabolism_Homo sapiens_hsa004100.95356564
67Arginine and proline metabolism_Homo sapiens_hsa003300.95064857
68Sulfur metabolism_Homo sapiens_hsa009200.94876622
69Focal adhesion_Homo sapiens_hsa045100.92386858
70Prion diseases_Homo sapiens_hsa050200.92019048
71Selenocompound metabolism_Homo sapiens_hsa004500.89859740
72Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.88137183
73Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87604530
74Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.85515912
75Viral myocarditis_Homo sapiens_hsa054160.84098662
76African trypanosomiasis_Homo sapiens_hsa051430.83443176
77Chemokine signaling pathway_Homo sapiens_hsa040620.83042324
78Phenylalanine metabolism_Homo sapiens_hsa003600.81623620
79Bile secretion_Homo sapiens_hsa049760.80189306
80Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.78554786
81Glycerolipid metabolism_Homo sapiens_hsa005610.77727761
82Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.77653236
83Pentose phosphate pathway_Homo sapiens_hsa000300.77213068
84Sphingolipid metabolism_Homo sapiens_hsa006000.76482779
85Mineral absorption_Homo sapiens_hsa049780.74624132
86Hepatitis C_Homo sapiens_hsa051600.74445284
87Small cell lung cancer_Homo sapiens_hsa052220.73953414
88Carbon metabolism_Homo sapiens_hsa012000.73898546
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73502294
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73129726
91Fructose and mannose metabolism_Homo sapiens_hsa000510.72502992
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.72084371
93Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.71654627
94Biosynthesis of amino acids_Homo sapiens_hsa012300.71183908
95Tyrosine metabolism_Homo sapiens_hsa003500.70949049
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.68891186
97* Rheumatoid arthritis_Homo sapiens_hsa053230.66669913
98* Apoptosis_Homo sapiens_hsa042100.66008227
99Pertussis_Homo sapiens_hsa051330.65123523
100Protein digestion and absorption_Homo sapiens_hsa049740.64998527
101* Proteoglycans in cancer_Homo sapiens_hsa052050.64586830
102Legionellosis_Homo sapiens_hsa051340.63608066
103Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.63313362
104Adipocytokine signaling pathway_Homo sapiens_hsa049200.61311106
105Herpes simplex infection_Homo sapiens_hsa051680.60813354
106Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.58975838
107Synaptic vesicle cycle_Homo sapiens_hsa047210.58579751
108Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.58452531
109SNARE interactions in vesicular transport_Homo sapiens_hsa041300.58193323
110Hepatitis B_Homo sapiens_hsa051610.57806115
111Pyruvate metabolism_Homo sapiens_hsa006200.57248345
112B cell receptor signaling pathway_Homo sapiens_hsa046620.55314151
113Measles_Homo sapiens_hsa051620.54735043
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.54163105
115AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.53926651
116Cysteine and methionine metabolism_Homo sapiens_hsa002700.53809998
117TGF-beta signaling pathway_Homo sapiens_hsa043500.52882207
118Toxoplasmosis_Homo sapiens_hsa051450.52519123
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.52470047
120Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52151208
121Fatty acid biosynthesis_Homo sapiens_hsa000610.52045597
122HIF-1 signaling pathway_Homo sapiens_hsa040660.51014535
123Sulfur relay system_Homo sapiens_hsa041220.49535359
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49123695
125Renin-angiotensin system_Homo sapiens_hsa046140.48973645
126Tuberculosis_Homo sapiens_hsa051520.48960847
127Galactose metabolism_Homo sapiens_hsa000520.45839872
128alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.44908386
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.44711769
130Bladder cancer_Homo sapiens_hsa052190.43487896
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.43219034
132ABC transporters_Homo sapiens_hsa020100.42497137
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.42145270
134Endocytosis_Homo sapiens_hsa041440.42127226
135Acute myeloid leukemia_Homo sapiens_hsa052210.40524797
136Leishmaniasis_Homo sapiens_hsa051400.40189177
137Osteoclast differentiation_Homo sapiens_hsa043800.39433181
138Adherens junction_Homo sapiens_hsa045200.38803202
139Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.38676313
140Insulin resistance_Homo sapiens_hsa049310.38405351
141TNF signaling pathway_Homo sapiens_hsa046680.37628547
142Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30668207
143Prolactin signaling pathway_Homo sapiens_hsa049170.30608575
144VEGF signaling pathway_Homo sapiens_hsa043700.26904378
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.24180850
146Renal cell carcinoma_Homo sapiens_hsa052110.23978945
147Epstein-Barr virus infection_Homo sapiens_hsa051690.21004716
148Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21002146
149Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.18988188
150Pancreatic cancer_Homo sapiens_hsa052120.16861871
151Central carbon metabolism in cancer_Homo sapiens_hsa052300.15266208
152HTLV-I infection_Homo sapiens_hsa051660.12397425
153Chronic myeloid leukemia_Homo sapiens_hsa052200.12356725
154Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12030431
155Type II diabetes mellitus_Homo sapiens_hsa049300.10235164

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