ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of oligodendrocyte differentiation (GO:0048715)	8.00562151
2	axonemal dynein complex assembly (GO:0070286)	7.43754750
3	negative regulation of astrocyte differentiation (GO:0048712)	7.13477603
4	pattern specification involved in kidney development (GO:0061004)	6.96292011
5	response to auditory stimulus (GO:0010996)	6.38626759
6	prepulse inhibition (GO:0060134)	6.32724505
7	cilium or flagellum-dependent cell motility (GO:0001539)	6.27371502
8	retinal rod cell development (GO:0046548)	6.19274080
9	peripheral nervous system neuron development (GO:0048935)	6.15792747
10	regulation of Rac GTPase activity (GO:0032314)	6.02885799
11	neuronal stem cell maintenance (GO:0097150)	5.81335540
12	positive regulation of vascular permeability (GO:0043117)	5.73605372
13	cell proliferation in forebrain (GO:0021846)	5.60826800
14	mechanoreceptor differentiation (GO:0042490)	5.41865363
15	auditory receptor cell differentiation (GO:0042491)	5.41293171
16	epithelial cilium movement (GO:0003351)	5.31494391
17	cerebral cortex neuron differentiation (GO:0021895)	5.17241891
18	radial glial cell differentiation (GO:0060019)	4.93311101
19	dermatan sulfate biosynthetic process (GO:0030208)	4.66189929
20	nephron epithelium morphogenesis (GO:0072088)	4.51867438
21	nephron tubule morphogenesis (GO:0072078)	4.51867438
22	neuron fate determination (GO:0048664)	4.51440100
23	ionotropic glutamate receptor signaling pathway (GO:0035235)	4.50170126
24	neurotransmitter uptake (GO:0001504)	4.46862321
25	negative regulation of glial cell differentiation (GO:0045686)	4.33805667
26	proline biosynthetic process (GO:0006561)	4.27895602
27	cilium movement (GO:0003341)	4.23894387
28	negative regulation of organelle assembly (GO:1902116)	4.17993372
29	dermatan sulfate metabolic process (GO:0030205)	4.12356344
30	calcium-mediated signaling using intracellular calcium source (GO:0035584)	4.04589353
31	negative regulation of adenylate cyclase activity (GO:0007194)	4.04310393
32	neuroblast proliferation (GO:0007405)	3.96465001
33	negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)	3.94848565
34	protein refolding (GO:0042026)	3.94820985
35	oligodendrocyte differentiation (GO:0048709)	3.91644045
36	toxin transport (GO:1901998)	3.90155982
37	positive regulation of synaptic transmission, glutamatergic (GO:0051968)	3.89540124
38	negative regulation of lyase activity (GO:0051350)	3.84451346
39	astrocyte differentiation (GO:0048708)	3.84291663
40	negative regulation of cyclase activity (GO:0031280)	3.84015232
41	regulation of astrocyte differentiation (GO:0048710)	3.74312807
42	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.62927901
43	segment specification (GO:0007379)	3.60198241
44	serotonin metabolic process (GO:0042428)	3.50771486
45	negative regulation of anoikis (GO:2000811)	3.48283158
46	C4-dicarboxylate transport (GO:0015740)	3.47573601
47	negative regulation of cAMP biosynthetic process (GO:0030818)	3.45461611
48	negative regulation of cAMP metabolic process (GO:0030815)	3.40052801
49	inner ear receptor cell differentiation (GO:0060113)	3.37385950
50	glomerular filtration (GO:0003094)	3.33074151
51	negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)	3.32079265
52	regulation of oligodendrocyte differentiation (GO:0048713)	3.30928049
53	motile cilium assembly (GO:0044458)	3.29439701
54	glutamate receptor signaling pathway (GO:0007215)	3.29374933
55	negative regulation of cyclic nucleotide metabolic process (GO:0030800)	3.27972051
56	enteric nervous system development (GO:0048484)	3.27596393
57	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.25880493
58	behavioral response to nicotine (GO:0035095)	3.24324104
59	negative regulation of nucleotide biosynthetic process (GO:0030809)	3.20905919
60	negative regulation of purine nucleotide biosynthetic process (GO:1900372)	3.20905919
61	synaptic transmission, glutamatergic (GO:0035249)	3.20854730
62	proline metabolic process (GO:0006560)	3.20533023
63	photoreceptor cell differentiation (GO:0046530)	3.19199769
64	eye photoreceptor cell differentiation (GO:0001754)	3.19199769
65	peptidyl-cysteine modification (GO:0018198)	3.17733859
66	postsynaptic membrane organization (GO:0001941)	3.11389488
67	neural precursor cell proliferation (GO:0061351)	3.08798435
68	tongue development (GO:0043586)	3.05052602
69	primary amino compound metabolic process (GO:1901160)	3.02097225
70	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.97742735
71	vascular smooth muscle contraction (GO:0014829)	2.93872356
72	hair cell differentiation (GO:0035315)	2.92928052
73	estrogen biosynthetic process (GO:0006703)	2.92285976
74	G-protein coupled receptor internalization (GO:0002031)	2.91902069
75	pyrimidine-containing compound transmembrane transport (GO:0072531)	2.89868555
76	negative regulation of gliogenesis (GO:0014014)	2.88836772
77	positive regulation of guanylate cyclase activity (GO:0031284)	2.87995272
78	regulation of cilium movement (GO:0003352)	2.87821740
79	renal filtration (GO:0097205)	2.86888381
80	activation of adenylate cyclase activity (GO:0007190)	2.86422376
81	regulation of adenylate cyclase activity (GO:0045761)	2.83424380
82	regulation of cyclase activity (GO:0031279)	2.83257597
83	positive regulation of meiotic cell cycle (GO:0051446)	2.83117403
84	renal tubule morphogenesis (GO:0061333)	2.82497155
85	regulation of collateral sprouting (GO:0048670)	2.82284903
86	regulation of lyase activity (GO:0051339)	2.81037328
87	proteasome assembly (GO:0043248)	2.80063640
88	pseudouridine synthesis (GO:0001522)	2.79846139
89	chondroitin sulfate catabolic process (GO:0030207)	2.75126360
90	positive regulation of Notch signaling pathway (GO:0045747)	2.74409187
91	response to gravity (GO:0009629)	2.72487276
92	centriole replication (GO:0007099)	2.72302422
93	nephron tubule formation (GO:0072079)	2.70657724
94	intracellular protein transmembrane import (GO:0044743)	2.67516656
95	response to nitrosative stress (GO:0051409)	2.67017863
96	dopaminergic neuron differentiation (GO:0071542)	2.65815582
97	histamine secretion (GO:0001821)	2.65752687
98	central nervous system myelination (GO:0022010)	13.9592561
99	axon ensheathment in central nervous system (GO:0032291)	13.9592561
100	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	10.4069547

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	5.96252375
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.20948724
3	ZNF274_21170338_ChIP-Seq_K562_Hela	2.86491322
4	NOTCH1_21737748_ChIP-Seq_TLL_Human	2.80420908
5	SALL1_21062744_ChIP-ChIP_HESCs_Human	2.73985498
6	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.68771009
7	VDR_22108803_ChIP-Seq_LS180_Human	2.44995494
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.35669160
9	FUS_26573619_Chip-Seq_HEK293_Human	2.35380827
10	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.35026007
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.29823344
12	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.28091179
13	P300_19829295_ChIP-Seq_ESCs_Human	2.23702741
14	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.07998163
15	AR_21572438_ChIP-Seq_LNCaP_Human	1.93103800
16	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.90640758
17	TRIM28_21343339_ChIP-Seq_HEK293_Human	1.90288366
18	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.87593955
19	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.87593955
20	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.86097971
21	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.84082994
22	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.80673423
23	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.77259076
24	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.76114996
25	GBX2_23144817_ChIP-Seq_PC3_Human	1.76090260
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.73939435
27	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.73390518
28	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.72525915
29	EWS_26573619_Chip-Seq_HEK293_Human	1.72455077
30	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.72427209
31	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.70775860
32	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.67809260
33	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.62613094
34	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.59806247
35	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.58819508
36	STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse	1.55447689
37	GATA1_22025678_ChIP-Seq_K562_Human	1.53140344
38	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.53079195
39	TBX3_20139965_ChIP-Seq_MESCs_Mouse	1.52742976
40	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.52444232
41	TBX3_20139965_ChIP-Seq_ESCs_Mouse	1.50905146
42	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.50768254
43	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.47761157
44	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.47659656
45	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.47631131
46	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.45753333
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.45335339
48	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.45290409
49	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.42836337
50	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.40238366
51	ER_23166858_ChIP-Seq_MCF-7_Human	1.39769022
52	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.38499649
53	AR_25329375_ChIP-Seq_VCAP_Human	1.38122624
54	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.37840148
55	STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse	1.37221883
56	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.36109264
57	HTT_18923047_ChIP-ChIP_STHdh_Human	1.36052834
58	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35687983
59	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.35564469
60	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30008855
61	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.28965092
62	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.28965092
63	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.25515348
64	REST_21632747_ChIP-Seq_MESCs_Mouse	1.25224362
65	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24765921
66	IGF1R_20145208_ChIP-Seq_DFB_Human	1.24036488
67	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.23037581
68	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22383937
69	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.21300719
70	PHF8_20622853_ChIP-Seq_HELA_Human	1.21062898
71	TCF4_22108803_ChIP-Seq_LS180_Human	1.20262266
72	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.19275174
73	CDX2_19796622_ChIP-Seq_MESCs_Mouse	1.17947927
74	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.17456255
75	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.16973419
76	CDX2_22108803_ChIP-Seq_LS180_Human	1.14241551
77	JUN_21703547_ChIP-Seq_K562_Human	1.14093246
78	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12816914
79	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12343514
80	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12343514
81	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.11816741
82	STAT3_23295773_ChIP-Seq_U87_Human	1.11043799
83	RNF2_27304074_Chip-Seq_NSC_Mouse	1.10994416
84	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.10426658
85	CBP_20019798_ChIP-Seq_JUKART_Human	1.09632215
86	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.09632215
87	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06581958
88	RUNX2_22187159_ChIP-Seq_PCA_Human	1.06239441
89	CBP_21632823_ChIP-Seq_H3396_Human	1.06172304
90	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.04866228
91	BCAT_22108803_ChIP-Seq_LS180_Human	1.02997728
92	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02489507
93	HNFA_21074721_ChIP-Seq_CACO-2_Human	1.01715019
94	YAP1_20516196_ChIP-Seq_MESCs_Mouse	1.01696514
95	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	1.00742161
96	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.00288692
97	TBL1_22424771_ChIP-Seq_293T_Human	0.99275924
98	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.98747787
99	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.98747787
100	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.96331169

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	8.23118477
2	MP0002638_abnormal_pupillary_reflex	5.62675106
3	MP0002653_abnormal_ependyma_morphology	5.26616944
4	MP0004885_abnormal_endolymph	4.62457907
5	MP0004858_abnormal_nervous_system	3.96685097
6	MP0003693_abnormal_embryo_hatching	3.23062652
7	MP0003300_gastrointestinal_ulcer	2.92334808
8	MP0001485_abnormal_pinna_reflex	2.80929547
9	MP0001968_abnormal_touch/_nociception	2.60855094
10	MP0000383_abnormal_hair_follicle	2.49264183
11	MP0002736_abnormal_nociception_after	2.37474053
12	MP0000427_abnormal_hair_cycle	2.31102885
13	MP0004147_increased_porphyrin_level	2.26838413
14	MP0004859_abnormal_synaptic_plasticity	2.04371640
15	MP0003718_maternal_effect	1.99519941
16	MP0000647_abnormal_sebaceous_gland	1.96878803
17	MP0010678_abnormal_skin_adnexa	1.93445442
18	MP0003646_muscle_fatigue	1.91123576
19	MP0005167_abnormal_blood-brain_barrier	1.86252209
20	MP0002572_abnormal_emotion/affect_behav	1.69919460
21	MP0004043_abnormal_pH_regulation	1.69691108
22	MP0003638_abnormal_response/metabolism_	1.66892986
23	MP0005171_absent_coat_pigmentation	1.64636545
24	MP0002733_abnormal_thermal_nociception	1.61753415
25	MP0001501_abnormal_sleep_pattern	1.61589427
26	MP0002282_abnormal_trachea_morphology	1.61384371
27	MP0000026_abnormal_inner_ear	1.53798856
28	MP0001963_abnormal_hearing_physiology	1.53124773
29	MP0006276_abnormal_autonomic_nervous	1.51658266
30	MP0005377_hearing/vestibular/ear_phenot	1.46889530
31	MP0003878_abnormal_ear_physiology	1.46889530
32	MP0005551_abnormal_eye_electrophysiolog	1.45044045
33	MP0004133_heterotaxia	1.36718224
34	MP0001486_abnormal_startle_reflex	1.31860176
35	MP0003195_calcinosis	1.29078545
36	MP0003119_abnormal_digestive_system	1.27202187
37	MP0002090_abnormal_vision	1.26250644
38	MP0001970_abnormal_pain_threshold	1.25591036
39	MP0002734_abnormal_mechanical_nocicepti	1.21983755
40	MP0003890_abnormal_embryonic-extraembry	1.20061816
41	MP0002735_abnormal_chemical_nociception	1.14655827
42	MP0001348_abnormal_lacrimal_gland	1.14116625
43	MP0003634_abnormal_glial_cell	1.13898328
44	MP0002272_abnormal_nervous_system	1.13511291
45	MP0000569_abnormal_digit_pigmentation	1.08059164
46	MP0005410_abnormal_fertilization	1.07224346
47	MP0001727_abnormal_embryo_implantation	1.06099233
48	MP0004742_abnormal_vestibular_system	1.05332728
49	MP0003635_abnormal_synaptic_transmissio	1.03537501
50	MP0008058_abnormal_DNA_repair	1.02150077
51	MP0002102_abnormal_ear_morphology	1.00601360
52	MP0002277_abnormal_respiratory_mucosa	0.99463129
53	MP0001929_abnormal_gametogenesis	0.97365467
54	MP0001905_abnormal_dopamine_level	0.90226978
55	MP0002067_abnormal_sensory_capabilities	0.90089799
56	MP0005253_abnormal_eye_physiology	0.89434765
57	MP0002064_seizures	0.88739524
58	MP0000778_abnormal_nervous_system	0.87102833
59	MP0010094_abnormal_chromosome_stability	0.85731147
60	MP0003632_abnormal_nervous_system	0.85728653
61	MP0002063_abnormal_learning/memory/cond	0.85644039
62	MP0000613_abnormal_salivary_gland	0.85184801
63	MP0001986_abnormal_taste_sensitivity	0.84822100
64	MP0002796_impaired_skin_barrier	0.83521642
65	MP0008872_abnormal_physiological_respon	0.82730530
66	MP0000467_abnormal_esophagus_morphology	0.81762854
67	MP0000762_abnormal_tongue_morphology	0.80418611
68	MP0002184_abnormal_innervation	0.79532816
69	MP0005023_abnormal_wound_healing	0.79479979
70	MP0004019_abnormal_vitamin_homeostasis	0.79142635
71	MP0005645_abnormal_hypothalamus_physiol	0.75942758
72	MP0009745_abnormal_behavioral_response	0.75663056
73	MP0001849_ear_inflammation	0.75378376
74	MP0008004_abnormal_stomach_pH	0.74376789
75	MP0002837_dystrophic_cardiac_calcinosis	0.71263174
76	MP0005195_abnormal_posterior_eye	0.70763209
77	MP0005365_abnormal_bile_salt	0.69089958
78	MP0003698_abnormal_male_reproductive	0.68576499
79	MP0005623_abnormal_meninges_morphology	0.67301974
80	MP0004142_abnormal_muscle_tone	0.66791523
81	MP0002210_abnormal_sex_determination	0.64259288
82	MP0003329_amyloid_beta_deposits	0.63146733
83	MP0004782_abnormal_surfactant_physiolog	0.62084039
84	MP0008995_early_reproductive_senescence	0.61732749
85	MP0000749_muscle_degeneration	0.60539884
86	MP0005423_abnormal_somatic_nervous	0.60014216
87	MP0000230_abnormal_systemic_arterial	0.59839677
88	MP0001293_anophthalmia	0.59504218
89	MP0005174_abnormal_tail_pigmentation	0.57972608
90	MP0002557_abnormal_social/conspecific_i	0.56430300
91	MP0004215_abnormal_myocardial_fiber	0.52867647
92	MP0009115_abnormal_fat_cell	0.51752311
93	MP0004233_abnormal_muscle_weight	0.51483164
94	MP0002152_abnormal_brain_morphology	0.50077122
95	MP0002098_abnormal_vibrissa_morphology	0.49338827
96	MP0008775_abnormal_heart_ventricle	0.48992531
97	MP0000653_abnormal_sex_gland	0.48693270
98	MP0001764_abnormal_homeostasis	0.48135062
99	MP0000538_abnormal_urinary_bladder	0.47596887
100	MP0009840_abnormal_foam_cell	0.45189572

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Absent/shortened dynein arms (HP:0200106)	7.73108660
2	Dynein arm defect of respiratory motile cilia (HP:0012255)	7.73108660
3	Increased hepatocellular lipid droplets (HP:0006565)	6.02179971
4	Lipid accumulation in hepatocytes (HP:0006561)	5.81698680
5	Abnormal respiratory motile cilium physiology (HP:0012261)	5.62629121
6	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	5.49936323
7	Birth length less than 3rd percentile (HP:0003561)	5.19262470
8	Abnormal respiratory motile cilium morphology (HP:0005938)	5.05803921
9	Abnormal respiratory epithelium morphology (HP:0012253)	5.05803921
10	Abnormal ciliary motility (HP:0012262)	4.98413160
11	Supernumerary spleens (HP:0009799)	4.82535615
12	Renal Fanconi syndrome (HP:0001994)	4.71750762
13	Aplasia/Hypoplasia of the sternum (HP:0006714)	4.08068870
14	Exertional dyspnea (HP:0002875)	4.01190820
15	Breast hypoplasia (HP:0003187)	3.93781491
16	Increased intramyocellular lipid droplets (HP:0012240)	3.84140193
17	Polyphagia (HP:0002591)	3.69852833
18	Chronic sinusitis (HP:0011109)	3.56871398
19	Increased muscle lipid content (HP:0009058)	3.43750841
20	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.35628436
21	Microretrognathia (HP:0000308)	3.22677050
22	Rhinitis (HP:0012384)	3.18439604
23	Diastasis recti (HP:0001540)	3.09396533
24	Metabolic alkalosis (HP:0200114)	3.07499243
25	Increased circulating renin level (HP:0000848)	3.05957637
26	Respiratory difficulties (HP:0002880)	3.04083221
27	Abnormality of urine glucose concentration (HP:0011016)	3.02338313
28	Glycosuria (HP:0003076)	3.02338313
29	Septo-optic dysplasia (HP:0100842)	2.99904383
30	True hermaphroditism (HP:0010459)	2.96160336
31	Hypokalemic alkalosis (HP:0001949)	2.95930062
32	Chronic bronchitis (HP:0004469)	2.90938969
33	Congenital primary aphakia (HP:0007707)	2.82539596
34	Abnormality of renal resorption (HP:0011038)	2.81615210
35	Gait imbalance (HP:0002141)	2.79154691
36	Esophageal atresia (HP:0002032)	2.74800638
37	Hyperphosphaturia (HP:0003109)	2.65707839
38	Polydipsia (HP:0001959)	2.56007141
39	Abnormal drinking behavior (HP:0030082)	2.56007141
40	Pancreatic cysts (HP:0001737)	2.54221709
41	Hepatoblastoma (HP:0002884)	2.48221831
42	Abnormality of cochlea (HP:0000375)	2.46730398
43	Medial flaring of the eyebrow (HP:0010747)	2.43615712
44	Polyuria (HP:0000103)	2.41800760
45	Aplasia/Hypoplasia involving the musculature (HP:0001460)	2.39167133
46	Fibular hypoplasia (HP:0003038)	2.38721902
47	Nephrogenic diabetes insipidus (HP:0009806)	2.37997134
48	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.35834586
49	Hyperventilation (HP:0002883)	2.29863176
50	Abnormal eating behavior (HP:0100738)	2.28142458
51	Bronchiectasis (HP:0002110)	2.18160850
52	Spastic paraparesis (HP:0002313)	2.16189818
53	Cortical dysplasia (HP:0002539)	2.16108158
54	Pancreatic fibrosis (HP:0100732)	2.15374110
55	Aplasia/Hypoplasia of the pubic bone (HP:0009104)	2.15359085
56	Large for gestational age (HP:0001520)	2.14871054
57	Nephronophthisis (HP:0000090)	2.14805748
58	Absent septum pellucidum (HP:0001331)	2.14481917
59	Increased density of long bones (HP:0006392)	2.14055661
60	Scrotal hypoplasia (HP:0000046)	2.13868393
61	Poor coordination (HP:0002370)	2.12477714
62	Renal salt wasting (HP:0000127)	2.07204617
63	Missing ribs (HP:0000921)	2.01480570
64	Abnormal urine phosphate concentration (HP:0012599)	1.99741878
65	Abnormal urine output (HP:0012590)	1.99492961
66	Congenital stationary night blindness (HP:0007642)	1.97493193
67	Abnormality of the renal medulla (HP:0100957)	1.96738638
68	Vaginal atresia (HP:0000148)	1.96661631
69	Genital tract atresia (HP:0001827)	1.96462264
70	Sclerocornea (HP:0000647)	1.95426070
71	Hypomagnesemia (HP:0002917)	1.93757661
72	Anophthalmia (HP:0000528)	1.90978850
73	Chorioretinal atrophy (HP:0000533)	1.90358007
74	Albinism (HP:0001022)	1.88979826
75	Abnormality of the septum pellucidum (HP:0007375)	1.88076277
76	Abnormality of the labia minora (HP:0012880)	1.86616221
77	Occipital encephalocele (HP:0002085)	1.82720344
78	Aplasia/Hypoplasia of the fibula (HP:0006492)	1.81229847
79	Patellar aplasia (HP:0006443)	1.80201124
80	Morphological abnormality of the inner ear (HP:0011390)	1.79348923
81	Widely spaced teeth (HP:0000687)	1.78939656
82	Mitochondrial inheritance (HP:0001427)	1.78751236
83	Hyperaldosteronism (HP:0000859)	1.77755484
84	Myokymia (HP:0002411)	1.76890291
85	Tubulointerstitial nephritis (HP:0001970)	1.76751725
86	Abnormality of the renal cortex (HP:0011035)	1.76500535
87	Vertebral hypoplasia (HP:0008417)	1.76371873
88	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	1.76371873
89	Tubulointerstitial abnormality (HP:0001969)	1.76336525
90	Optic nerve hypoplasia (HP:0000609)	1.76325545
91	Aplasia/Hypoplasia of the patella (HP:0006498)	1.75034547
92	Abnormal biliary tract physiology (HP:0012439)	1.72031579
93	Bile duct proliferation (HP:0001408)	1.72031579
94	Gastrointestinal atresia (HP:0002589)	1.71996196
95	Oligodactyly (hands) (HP:0001180)	1.71681840
96	Poor speech (HP:0002465)	1.71268390
97	Poor suck (HP:0002033)	1.70681161
98	Nasal speech (HP:0001611)	1.70498944
99	Rib fusion (HP:0000902)	1.68964004
100	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.68252161

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	6.69926078
2	NTRK2	5.60835200
3	CASK	4.06429898
4	WEE1	3.78691005
5	FGR	3.45223853
6	TAF1	3.39909018
7	MAPK15	2.42651429
8	ACVR1B	2.29890371
9	TSSK6	2.28929432
10	PRKD3	2.06479667
11	BMPR1B	2.05937935
12	MET	1.96584316
13	MAP3K9	1.86164503
14	DAPK2	1.80883110
15	ZAK	1.66839584
16	ARAF	1.59403574
17	MAP3K13	1.56581678
18	PKN1	1.54130843
19	BMX	1.52511783
20	STK38L	1.41446266
21	PTK2B	1.40298941
22	PIM2	1.39613953
23	RAF1	1.37880512
24	PDK2	1.36049917
25	NME1	1.35872202
26	EIF2AK1	1.26882570
27	LATS1	1.26111528
28	MAPK13	1.22684092
29	MAP2K2	1.18507559
30	NTRK3	1.07769009
31	MOS	1.07658425
32	FES	1.04428776
33	CDK3	1.01650624
34	JAK3	1.00364850
35	VRK1	0.99301758
36	MAP2K1	0.97848498
37	WNK4	0.97608634
38	CSF1R	0.92375427
39	ROCK1	0.83814589
40	TLK1	0.82387282
41	TGFBR1	0.81367900
42	NEK9	0.79966018
43	MST4	0.78280816
44	PINK1	0.78073188
45	CDC7	0.77838058
46	KSR2	0.76823661
47	EIF2AK3	0.76263413
48	BRSK2	0.75022404
49	NEK2	0.74488839
50	STK39	0.73134129
51	OXSR1	0.67953937
52	PLK2	0.66408236
53	PLK4	0.66164157
54	CSNK1G2	0.61593672
55	CAMK2A	0.61372496
56	MKNK2	0.59724982
57	VRK2	0.59272976
58	MKNK1	0.58813964
59	CAMKK1	0.58347072
60	PAK2	0.56552126
61	PRKCG	0.56532637
62	ADRBK2	0.55521433
63	TTK	0.55046472
64	PLK3	0.51571326
65	PRKCI	0.50117644
66	FRK	0.46653975
67	ADRBK1	0.44947879
68	GSK3A	0.44490154
69	BRAF	0.43205010
70	PLK1	0.42903587
71	CSNK1G1	0.41972286
72	INSRR	0.40951700
73	LATS2	0.39759662
74	PDGFRB	0.38471092
75	CDK5	0.36601593
76	PRKCZ	0.35803835
77	PAK6	0.35643932
78	KSR1	0.33786332
79	ABL1	0.32156837
80	TNIK	0.31186499
81	CSNK1G3	0.27958305
82	EGFR	0.27320108
83	PIM1	0.26665997
84	DYRK2	0.25400619
85	GRK7	0.23959003
86	NEK6	0.22918746
87	PBK	0.22837851
88	TYRO3	0.21167637
89	CSNK2A1	0.20418767
90	MELK	0.20185410
91	MAPK7	0.19285365
92	DYRK1A	0.19167110
93	INSR	0.17065251
94	MAPK3	0.16927779
95	LYN	0.16290260
96	NLK	0.15814718
97	CSNK1E	0.15466351
98	MAP3K7	0.15293015
99	SIK2	0.14830223
100	ROCK2	0.14116931

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	7.36982421
2	Fatty acid biosynthesis_Homo sapiens_hsa00061	3.23162530
3	Nicotine addiction_Homo sapiens_hsa05033	3.22086550
4	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	2.94424969
5	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.20459761
6	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	2.19434193
7	PPAR signaling pathway_Homo sapiens_hsa03320	2.17311027
8	Basal transcription factors_Homo sapiens_hsa03022	2.16704256
9	Collecting duct acid secretion_Homo sapiens_hsa04966	2.14580429
10	Protein export_Homo sapiens_hsa03060	2.13114903
11	Nitrogen metabolism_Homo sapiens_hsa00910	2.08066337
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.00124392
13	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.96081159
14	GABAergic synapse_Homo sapiens_hsa04727	1.95470164
15	Phototransduction_Homo sapiens_hsa04744	1.92585877
16	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.73302775
17	Morphine addiction_Homo sapiens_hsa05032	1.57515063
18	Estrogen signaling pathway_Homo sapiens_hsa04915	1.47629582
19	Ether lipid metabolism_Homo sapiens_hsa00565	1.42182371
20	Arginine and proline metabolism_Homo sapiens_hsa00330	1.39641488
21	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.38655743
22	cAMP signaling pathway_Homo sapiens_hsa04024	1.33368846
23	Oxidative phosphorylation_Homo sapiens_hsa00190	1.31589466
24	ABC transporters_Homo sapiens_hsa02010	1.31383680
25	Homologous recombination_Homo sapiens_hsa03440	1.31243579
26	Cocaine addiction_Homo sapiens_hsa05030	1.30353655
27	Selenocompound metabolism_Homo sapiens_hsa00450	1.28892043
28	Propanoate metabolism_Homo sapiens_hsa00640	1.23100573
29	Glutamatergic synapse_Homo sapiens_hsa04724	1.15225490
30	Antigen processing and presentation_Homo sapiens_hsa04612	1.12586932
31	Taste transduction_Homo sapiens_hsa04742	1.08122013
32	Glycerolipid metabolism_Homo sapiens_hsa00561	1.07677314
33	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.01030205
34	Olfactory transduction_Homo sapiens_hsa04740	0.97296497
35	Histidine metabolism_Homo sapiens_hsa00340	0.96936892
36	Non-homologous end-joining_Homo sapiens_hsa03450	0.95137356
37	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.92139526
38	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.90031098
39	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.88760048
40	Cell cycle_Homo sapiens_hsa04110	0.87728824
41	Fatty acid metabolism_Homo sapiens_hsa01212	0.87449381
42	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.86716017
43	Fanconi anemia pathway_Homo sapiens_hsa03460	0.85379577
44	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.84555098
45	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.83547301
46	Mineral absorption_Homo sapiens_hsa04978	0.83470175
47	Tryptophan metabolism_Homo sapiens_hsa00380	0.82362977
48	beta-Alanine metabolism_Homo sapiens_hsa00410	0.81544672
49	Gastric acid secretion_Homo sapiens_hsa04971	0.80260672
50	Butanoate metabolism_Homo sapiens_hsa00650	0.79811255
51	Amphetamine addiction_Homo sapiens_hsa05031	0.79682325
52	Folate biosynthesis_Homo sapiens_hsa00790	0.79404123
53	Legionellosis_Homo sapiens_hsa05134	0.78359688
54	Parkinsons disease_Homo sapiens_hsa05012	0.77169569
55	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76610124
56	Serotonergic synapse_Homo sapiens_hsa04726	0.76141084
57	Pyruvate metabolism_Homo sapiens_hsa00620	0.75380092
58	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.74444355
59	Fatty acid degradation_Homo sapiens_hsa00071	0.74168880
60	Cardiac muscle contraction_Homo sapiens_hsa04260	0.74064120
61	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.71044804
62	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.70903513
63	Fc epsilon RI signaling pathway_Homo sapiens_hsa04664	0.65890145
64	Hippo signaling pathway_Homo sapiens_hsa04390	0.64461677
65	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.62990717
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.62507589
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.59791356
68	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.59348961
69	Tyrosine metabolism_Homo sapiens_hsa00350	0.59016510
70	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.58447335
71	Vibrio cholerae infection_Homo sapiens_hsa05110	0.53346741
72	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.47306988
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47272312
74	Peroxisome_Homo sapiens_hsa04146	0.46022509
75	ECM-receptor interaction_Homo sapiens_hsa04512	0.44789867
76	Calcium signaling pathway_Homo sapiens_hsa04020	0.44036517
77	Bile secretion_Homo sapiens_hsa04976	0.42410968
78	Huntingtons disease_Homo sapiens_hsa05016	0.40011171
79	Renin-angiotensin system_Homo sapiens_hsa04614	0.39663901
80	Steroid biosynthesis_Homo sapiens_hsa00100	0.38861617
81	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.38157970
82	Arginine biosynthesis_Homo sapiens_hsa00220	0.37232450
83	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.35824015
84	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.35802053
85	Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666	0.34674164
86	Notch signaling pathway_Homo sapiens_hsa04330	0.33635622
87	DNA replication_Homo sapiens_hsa03030	0.33579634
88	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.31704688
89	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.31495873
90	Metabolic pathways_Homo sapiens_hsa01100	0.30299318
91	Retinol metabolism_Homo sapiens_hsa00830	0.29853679
92	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.27640118
93	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.25016634
94	Phospholipase D signaling pathway_Homo sapiens_hsa04072	0.24839440
95	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.24164764
96	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.22509018
97	Chemokine signaling pathway_Homo sapiens_hsa04062	0.22283118
98	Circadian entrainment_Homo sapiens_hsa04713	0.21561685
99	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.21171856
100	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.20829089

CTSL3P

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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