CTSL3P

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of oligodendrocyte differentiation (GO:0048715)8.00562151
2axonemal dynein complex assembly (GO:0070286)7.43754750
3negative regulation of astrocyte differentiation (GO:0048712)7.13477603
4pattern specification involved in kidney development (GO:0061004)6.96292011
5response to auditory stimulus (GO:0010996)6.38626759
6prepulse inhibition (GO:0060134)6.32724505
7cilium or flagellum-dependent cell motility (GO:0001539)6.27371502
8retinal rod cell development (GO:0046548)6.19274080
9peripheral nervous system neuron development (GO:0048935)6.15792747
10regulation of Rac GTPase activity (GO:0032314)6.02885799
11neuronal stem cell maintenance (GO:0097150)5.81335540
12positive regulation of vascular permeability (GO:0043117)5.73605372
13cell proliferation in forebrain (GO:0021846)5.60826800
14mechanoreceptor differentiation (GO:0042490)5.41865363
15auditory receptor cell differentiation (GO:0042491)5.41293171
16epithelial cilium movement (GO:0003351)5.31494391
17cerebral cortex neuron differentiation (GO:0021895)5.17241891
18radial glial cell differentiation (GO:0060019)4.93311101
19dermatan sulfate biosynthetic process (GO:0030208)4.66189929
20nephron tubule morphogenesis (GO:0072078)4.51867438
21nephron epithelium morphogenesis (GO:0072088)4.51867438
22neuron fate determination (GO:0048664)4.51440100
23ionotropic glutamate receptor signaling pathway (GO:0035235)4.50170126
24neurotransmitter uptake (GO:0001504)4.46862321
25negative regulation of glial cell differentiation (GO:0045686)4.33805667
26proline biosynthetic process (GO:0006561)4.27895602
27cilium movement (GO:0003341)4.23894387
28negative regulation of organelle assembly (GO:1902116)4.17993372
29dermatan sulfate metabolic process (GO:0030205)4.12356344
30calcium-mediated signaling using intracellular calcium source (GO:0035584)4.04589353
31negative regulation of adenylate cyclase activity (GO:0007194)4.04310393
32neuroblast proliferation (GO:0007405)3.96465001
33negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.94848565
34protein refolding (GO:0042026)3.94820985
35oligodendrocyte differentiation (GO:0048709)3.91644045
36toxin transport (GO:1901998)3.90155982
37positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.89540124
38negative regulation of lyase activity (GO:0051350)3.84451346
39astrocyte differentiation (GO:0048708)3.84291663
40negative regulation of cyclase activity (GO:0031280)3.84015232
41regulation of astrocyte differentiation (GO:0048710)3.74312807
42detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.62927901
43segment specification (GO:0007379)3.60198241
44serotonin metabolic process (GO:0042428)3.50771486
45negative regulation of anoikis (GO:2000811)3.48283158
46C4-dicarboxylate transport (GO:0015740)3.47573601
47negative regulation of cAMP biosynthetic process (GO:0030818)3.45461611
48negative regulation of cAMP metabolic process (GO:0030815)3.40052801
49inner ear receptor cell differentiation (GO:0060113)3.37385950
50glomerular filtration (GO:0003094)3.33074151
51negative regulation of cyclic nucleotide biosynthetic process (GO:0030803)3.32079265
52regulation of oligodendrocyte differentiation (GO:0048713)3.30928049
53motile cilium assembly (GO:0044458)3.29439701
54glutamate receptor signaling pathway (GO:0007215)3.29374933
55negative regulation of cyclic nucleotide metabolic process (GO:0030800)3.27972051
56enteric nervous system development (GO:0048484)3.27596393
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.25880493
58behavioral response to nicotine (GO:0035095)3.24324104
59negative regulation of purine nucleotide biosynthetic process (GO:1900372)3.20905919
60negative regulation of nucleotide biosynthetic process (GO:0030809)3.20905919
61synaptic transmission, glutamatergic (GO:0035249)3.20854730
62proline metabolic process (GO:0006560)3.20533023
63photoreceptor cell differentiation (GO:0046530)3.19199769
64eye photoreceptor cell differentiation (GO:0001754)3.19199769
65peptidyl-cysteine modification (GO:0018198)3.17733859
66postsynaptic membrane organization (GO:0001941)3.11389488
67neural precursor cell proliferation (GO:0061351)3.08798435
68tongue development (GO:0043586)3.05052602
69primary amino compound metabolic process (GO:1901160)3.02097225
70gamma-aminobutyric acid signaling pathway (GO:0007214)2.97742735
71vascular smooth muscle contraction (GO:0014829)2.93872356
72hair cell differentiation (GO:0035315)2.92928052
73estrogen biosynthetic process (GO:0006703)2.92285976
74G-protein coupled receptor internalization (GO:0002031)2.91902069
75pyrimidine-containing compound transmembrane transport (GO:0072531)2.89868555
76negative regulation of gliogenesis (GO:0014014)2.88836772
77positive regulation of guanylate cyclase activity (GO:0031284)2.87995272
78regulation of cilium movement (GO:0003352)2.87821740
79renal filtration (GO:0097205)2.86888381
80activation of adenylate cyclase activity (GO:0007190)2.86422376
81regulation of adenylate cyclase activity (GO:0045761)2.83424380
82regulation of cyclase activity (GO:0031279)2.83257597
83positive regulation of meiotic cell cycle (GO:0051446)2.83117403
84renal tubule morphogenesis (GO:0061333)2.82497155
85regulation of collateral sprouting (GO:0048670)2.82284903
86regulation of lyase activity (GO:0051339)2.81037328
87proteasome assembly (GO:0043248)2.80063640
88pseudouridine synthesis (GO:0001522)2.79846139
89chondroitin sulfate catabolic process (GO:0030207)2.75126360
90positive regulation of Notch signaling pathway (GO:0045747)2.74409187
91response to gravity (GO:0009629)2.72487276
92centriole replication (GO:0007099)2.72302422
93nephron tubule formation (GO:0072079)2.70657724
94intracellular protein transmembrane import (GO:0044743)2.67516656
95response to nitrosative stress (GO:0051409)2.67017863
96dopaminergic neuron differentiation (GO:0071542)2.65815582
97histamine secretion (GO:0001821)2.65752687
98axon ensheathment in central nervous system (GO:0032291)13.9592561
99central nervous system myelination (GO:0022010)13.9592561
100epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)10.4069547

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.96252375
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.20948724
3ZNF274_21170338_ChIP-Seq_K562_Hela2.86491322
4NOTCH1_21737748_ChIP-Seq_TLL_Human2.80420908
5SALL1_21062744_ChIP-ChIP_HESCs_Human2.73985498
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.68771009
7VDR_22108803_ChIP-Seq_LS180_Human2.44995494
8CTBP1_25329375_ChIP-Seq_LNCAP_Human2.35669160
9FUS_26573619_Chip-Seq_HEK293_Human2.35380827
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35026007
11CTBP2_25329375_ChIP-Seq_LNCAP_Human2.29823344
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.28091179
13P300_19829295_ChIP-Seq_ESCs_Human2.23702741
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.07998163
15AR_21572438_ChIP-Seq_LNCaP_Human1.93103800
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.90640758
17TRIM28_21343339_ChIP-Seq_HEK293_Human1.90288366
18TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.87593955
19POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.87593955
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.86097971
21PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.84082994
22PIAS1_25552417_ChIP-Seq_VCAP_Human1.80673423
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.77259076
24SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.76114996
25GBX2_23144817_ChIP-Seq_PC3_Human1.76090260
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.73939435
27JARID2_20064375_ChIP-Seq_MESCs_Mouse1.73390518
28CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.72525915
29EWS_26573619_Chip-Seq_HEK293_Human1.72455077
30PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.72427209
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.70775860
32RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67809260
33KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.62613094
34SMAD3_21741376_ChIP-Seq_EPCs_Human1.59806247
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.58819508
36STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.55447689
37GATA1_22025678_ChIP-Seq_K562_Human1.53140344
38EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.53079195
39TBX3_20139965_ChIP-Seq_MESCs_Mouse1.52742976
40AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.52444232
41TBX3_20139965_ChIP-Seq_ESCs_Mouse1.50905146
42TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.50768254
43SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.47761157
44BMI1_23680149_ChIP-Seq_NPCS_Mouse1.47659656
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.47631131
46JARID2_20075857_ChIP-Seq_MESCs_Mouse1.45753333
47TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45335339
48EZH2_27304074_Chip-Seq_ESCs_Mouse1.45290409
49GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.42836337
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.40238366
51ER_23166858_ChIP-Seq_MCF-7_Human1.39769022
52UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38499649
53AR_25329375_ChIP-Seq_VCAP_Human1.38122624
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.37840148
55STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.37221883
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.36109264
57HTT_18923047_ChIP-ChIP_STHdh_Human1.36052834
58NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35687983
59RNF2_27304074_Chip-Seq_ESCs_Mouse1.35564469
60SMAD4_21799915_ChIP-Seq_A2780_Human1.30008855
61EZH2_18974828_ChIP-Seq_MESCs_Mouse1.28965092
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.28965092
63OCT1_27270436_Chip-Seq_PROSTATE_Human1.25515348
64REST_21632747_ChIP-Seq_MESCs_Mouse1.25224362
65SMAD4_21741376_ChIP-Seq_EPCs_Human1.24765921
66IGF1R_20145208_ChIP-Seq_DFB_Human1.24036488
67FOXA1_21572438_ChIP-Seq_LNCaP_Human1.23037581
68SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.22383937
69REST_18959480_ChIP-ChIP_MESCs_Mouse1.21300719
70PHF8_20622853_ChIP-Seq_HELA_Human1.21062898
71TCF4_22108803_ChIP-Seq_LS180_Human1.20262266
72SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.19275174
73CDX2_19796622_ChIP-Seq_MESCs_Mouse1.17947927
74ZFP57_27257070_Chip-Seq_ESCs_Mouse1.17456255
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.16973419
76CDX2_22108803_ChIP-Seq_LS180_Human1.14241551
77JUN_21703547_ChIP-Seq_K562_Human1.14093246
78GATA3_21878914_ChIP-Seq_MCF-7_Human1.12816914
79SOX2_19829295_ChIP-Seq_ESCs_Human1.12343514
80NANOG_19829295_ChIP-Seq_ESCs_Human1.12343514
81PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.11816741
82STAT3_23295773_ChIP-Seq_U87_Human1.11043799
83RNF2_27304074_Chip-Seq_NSC_Mouse1.10994416
84MTF2_20144788_ChIP-Seq_MESCs_Mouse1.10426658
85CBP_20019798_ChIP-Seq_JUKART_Human1.09632215
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09632215
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.06581958
88RUNX2_22187159_ChIP-Seq_PCA_Human1.06239441
89CBP_21632823_ChIP-Seq_H3396_Human1.06172304
90CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04866228
91BCAT_22108803_ChIP-Seq_LS180_Human1.02997728
92POU5F1_16153702_ChIP-ChIP_HESCs_Human1.02489507
93HNFA_21074721_ChIP-Seq_CACO-2_Human1.01715019
94YAP1_20516196_ChIP-Seq_MESCs_Mouse1.01696514
95KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00742161
96EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00288692
97TBL1_22424771_ChIP-Seq_293T_Human0.99275924
98FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98747787
99FOXA1_25329375_ChIP-Seq_VCAP_Human0.98747787
100ZNF217_24962896_ChIP-Seq_MCF-7_Human0.96331169

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color8.23118477
2MP0002638_abnormal_pupillary_reflex5.62675106
3MP0002653_abnormal_ependyma_morphology5.26616944
4MP0004885_abnormal_endolymph4.62457907
5MP0004858_abnormal_nervous_system3.96685097
6MP0003693_abnormal_embryo_hatching3.23062652
7MP0003300_gastrointestinal_ulcer2.92334808
8MP0001485_abnormal_pinna_reflex2.80929547
9MP0001968_abnormal_touch/_nociception2.60855094
10MP0000383_abnormal_hair_follicle2.49264183
11MP0002736_abnormal_nociception_after2.37474053
12MP0000427_abnormal_hair_cycle2.31102885
13MP0004147_increased_porphyrin_level2.26838413
14MP0004859_abnormal_synaptic_plasticity2.04371640
15MP0003718_maternal_effect1.99519941
16MP0000647_abnormal_sebaceous_gland1.96878803
17MP0010678_abnormal_skin_adnexa1.93445442
18MP0003646_muscle_fatigue1.91123576
19MP0005167_abnormal_blood-brain_barrier1.86252209
20MP0002572_abnormal_emotion/affect_behav1.69919460
21MP0004043_abnormal_pH_regulation1.69691108
22MP0003638_abnormal_response/metabolism_1.66892986
23MP0005171_absent_coat_pigmentation1.64636545
24MP0002733_abnormal_thermal_nociception1.61753415
25MP0001501_abnormal_sleep_pattern1.61589427
26MP0002282_abnormal_trachea_morphology1.61384371
27MP0000026_abnormal_inner_ear1.53798856
28MP0001963_abnormal_hearing_physiology1.53124773
29MP0006276_abnormal_autonomic_nervous1.51658266
30MP0003878_abnormal_ear_physiology1.46889530
31MP0005377_hearing/vestibular/ear_phenot1.46889530
32MP0005551_abnormal_eye_electrophysiolog1.45044045
33MP0004133_heterotaxia1.36718224
34MP0001486_abnormal_startle_reflex1.31860176
35MP0003195_calcinosis1.29078545
36MP0003119_abnormal_digestive_system1.27202187
37MP0002090_abnormal_vision1.26250644
38MP0001970_abnormal_pain_threshold1.25591036
39MP0002734_abnormal_mechanical_nocicepti1.21983755
40MP0003890_abnormal_embryonic-extraembry1.20061816
41MP0002735_abnormal_chemical_nociception1.14655827
42MP0001348_abnormal_lacrimal_gland1.14116625
43MP0003634_abnormal_glial_cell1.13898328
44MP0002272_abnormal_nervous_system1.13511291
45MP0000569_abnormal_digit_pigmentation1.08059164
46MP0005410_abnormal_fertilization1.07224346
47MP0001727_abnormal_embryo_implantation1.06099233
48MP0004742_abnormal_vestibular_system1.05332728
49MP0003635_abnormal_synaptic_transmissio1.03537501
50MP0008058_abnormal_DNA_repair1.02150077
51MP0002102_abnormal_ear_morphology1.00601360
52MP0002277_abnormal_respiratory_mucosa0.99463129
53MP0001929_abnormal_gametogenesis0.97365467
54MP0001905_abnormal_dopamine_level0.90226978
55MP0002067_abnormal_sensory_capabilities0.90089799
56MP0005253_abnormal_eye_physiology0.89434765
57MP0002064_seizures0.88739524
58MP0000778_abnormal_nervous_system0.87102833
59MP0010094_abnormal_chromosome_stability0.85731147
60MP0003632_abnormal_nervous_system0.85728653
61MP0002063_abnormal_learning/memory/cond0.85644039
62MP0000613_abnormal_salivary_gland0.85184801
63MP0001986_abnormal_taste_sensitivity0.84822100
64MP0002796_impaired_skin_barrier0.83521642
65MP0008872_abnormal_physiological_respon0.82730530
66MP0000467_abnormal_esophagus_morphology0.81762854
67MP0000762_abnormal_tongue_morphology0.80418611
68MP0002184_abnormal_innervation0.79532816
69MP0005023_abnormal_wound_healing0.79479979
70MP0004019_abnormal_vitamin_homeostasis0.79142635
71MP0005645_abnormal_hypothalamus_physiol0.75942758
72MP0009745_abnormal_behavioral_response0.75663056
73MP0001849_ear_inflammation0.75378376
74MP0008004_abnormal_stomach_pH0.74376789
75MP0002837_dystrophic_cardiac_calcinosis0.71263174
76MP0005195_abnormal_posterior_eye0.70763209
77MP0005365_abnormal_bile_salt0.69089958
78MP0003698_abnormal_male_reproductive0.68576499
79MP0005623_abnormal_meninges_morphology0.67301974
80MP0004142_abnormal_muscle_tone0.66791523
81MP0002210_abnormal_sex_determination0.64259288
82MP0003329_amyloid_beta_deposits0.63146733
83MP0004782_abnormal_surfactant_physiolog0.62084039
84MP0008995_early_reproductive_senescence0.61732749
85MP0000749_muscle_degeneration0.60539884
86MP0005423_abnormal_somatic_nervous0.60014216
87MP0000230_abnormal_systemic_arterial0.59839677
88MP0001293_anophthalmia0.59504218
89MP0005174_abnormal_tail_pigmentation0.57972608
90MP0002557_abnormal_social/conspecific_i0.56430300
91MP0004215_abnormal_myocardial_fiber0.52867647
92MP0009115_abnormal_fat_cell0.51752311
93MP0004233_abnormal_muscle_weight0.51483164
94MP0002152_abnormal_brain_morphology0.50077122
95MP0002098_abnormal_vibrissa_morphology0.49338827
96MP0008775_abnormal_heart_ventricle0.48992531
97MP0000653_abnormal_sex_gland0.48693270
98MP0001764_abnormal_homeostasis0.48135062
99MP0000538_abnormal_urinary_bladder0.47596887
100MP0009840_abnormal_foam_cell0.45189572

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)7.73108660
2Absent/shortened dynein arms (HP:0200106)7.73108660
3Increased hepatocellular lipid droplets (HP:0006565)6.02179971
4Lipid accumulation in hepatocytes (HP:0006561)5.81698680
5Abnormal respiratory motile cilium physiology (HP:0012261)5.62629121
6Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.49936323
7Birth length less than 3rd percentile (HP:0003561)5.19262470
8Abnormal respiratory epithelium morphology (HP:0012253)5.05803921
9Abnormal respiratory motile cilium morphology (HP:0005938)5.05803921
10Abnormal ciliary motility (HP:0012262)4.98413160
11Supernumerary spleens (HP:0009799)4.82535615
12Renal Fanconi syndrome (HP:0001994)4.71750762
13Aplasia/Hypoplasia of the sternum (HP:0006714)4.08068870
14Exertional dyspnea (HP:0002875)4.01190820
15Breast hypoplasia (HP:0003187)3.93781491
16Increased intramyocellular lipid droplets (HP:0012240)3.84140193
17Polyphagia (HP:0002591)3.69852833
18Chronic sinusitis (HP:0011109)3.56871398
19Increased muscle lipid content (HP:0009058)3.43750841
20Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.35628436
21Microretrognathia (HP:0000308)3.22677050
22Rhinitis (HP:0012384)3.18439604
23Diastasis recti (HP:0001540)3.09396533
24Metabolic alkalosis (HP:0200114)3.07499243
25Increased circulating renin level (HP:0000848)3.05957637
26Respiratory difficulties (HP:0002880)3.04083221
27Glycosuria (HP:0003076)3.02338313
28Abnormality of urine glucose concentration (HP:0011016)3.02338313
29Septo-optic dysplasia (HP:0100842)2.99904383
30True hermaphroditism (HP:0010459)2.96160336
31Hypokalemic alkalosis (HP:0001949)2.95930062
32Chronic bronchitis (HP:0004469)2.90938969
33Congenital primary aphakia (HP:0007707)2.82539596
34Abnormality of renal resorption (HP:0011038)2.81615210
35Gait imbalance (HP:0002141)2.79154691
36Esophageal atresia (HP:0002032)2.74800638
37Hyperphosphaturia (HP:0003109)2.65707839
38Abnormal drinking behavior (HP:0030082)2.56007141
39Polydipsia (HP:0001959)2.56007141
40Pancreatic cysts (HP:0001737)2.54221709
41Hepatoblastoma (HP:0002884)2.48221831
42Abnormality of cochlea (HP:0000375)2.46730398
43Medial flaring of the eyebrow (HP:0010747)2.43615712
44Polyuria (HP:0000103)2.41800760
45Aplasia/Hypoplasia involving the musculature (HP:0001460)2.39167133
46Fibular hypoplasia (HP:0003038)2.38721902
47Nephrogenic diabetes insipidus (HP:0009806)2.37997134
48Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35834586
49Hyperventilation (HP:0002883)2.29863176
50Abnormal eating behavior (HP:0100738)2.28142458
51Bronchiectasis (HP:0002110)2.18160850
52Spastic paraparesis (HP:0002313)2.16189818
53Cortical dysplasia (HP:0002539)2.16108158
54Pancreatic fibrosis (HP:0100732)2.15374110
55Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.15359085
56Large for gestational age (HP:0001520)2.14871054
57Nephronophthisis (HP:0000090)2.14805748
58Absent septum pellucidum (HP:0001331)2.14481917
59Increased density of long bones (HP:0006392)2.14055661
60Scrotal hypoplasia (HP:0000046)2.13868393
61Poor coordination (HP:0002370)2.12477714
62Renal salt wasting (HP:0000127)2.07204617
63Missing ribs (HP:0000921)2.01480570
64Abnormal urine phosphate concentration (HP:0012599)1.99741878
65Abnormal urine output (HP:0012590)1.99492961
66Congenital stationary night blindness (HP:0007642)1.97493193
67Abnormality of the renal medulla (HP:0100957)1.96738638
68Vaginal atresia (HP:0000148)1.96661631
69Genital tract atresia (HP:0001827)1.96462264
70Sclerocornea (HP:0000647)1.95426070
71Hypomagnesemia (HP:0002917)1.93757661
72Anophthalmia (HP:0000528)1.90978850
73Chorioretinal atrophy (HP:0000533)1.90358007
74Albinism (HP:0001022)1.88979826
75Abnormality of the septum pellucidum (HP:0007375)1.88076277
76Abnormality of the labia minora (HP:0012880)1.86616221
77Occipital encephalocele (HP:0002085)1.82720344
78Aplasia/Hypoplasia of the fibula (HP:0006492)1.81229847
79Patellar aplasia (HP:0006443)1.80201124
80Morphological abnormality of the inner ear (HP:0011390)1.79348923
81Widely spaced teeth (HP:0000687)1.78939656
82Mitochondrial inheritance (HP:0001427)1.78751236
83Hyperaldosteronism (HP:0000859)1.77755484
84Myokymia (HP:0002411)1.76890291
85Tubulointerstitial nephritis (HP:0001970)1.76751725
86Abnormality of the renal cortex (HP:0011035)1.76500535
87Aplasia/Hypoplasia of the vertebrae (HP:0008515)1.76371873
88Vertebral hypoplasia (HP:0008417)1.76371873
89Tubulointerstitial abnormality (HP:0001969)1.76336525
90Optic nerve hypoplasia (HP:0000609)1.76325545
91Aplasia/Hypoplasia of the patella (HP:0006498)1.75034547
92Bile duct proliferation (HP:0001408)1.72031579
93Abnormal biliary tract physiology (HP:0012439)1.72031579
94Gastrointestinal atresia (HP:0002589)1.71996196
95Oligodactyly (hands) (HP:0001180)1.71681840
96Poor speech (HP:0002465)1.71268390
97Poor suck (HP:0002033)1.70681161
98Nasal speech (HP:0001611)1.70498944
99Rib fusion (HP:0000902)1.68964004
100Decreased electroretinogram (ERG) amplitude (HP:0000654)1.68252161

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PNCK6.69926078
2NTRK25.60835200
3CASK4.06429898
4WEE13.78691005
5FGR3.45223853
6TAF13.39909018
7MAPK152.42651429
8ACVR1B2.29890371
9TSSK62.28929432
10PRKD32.06479667
11BMPR1B2.05937935
12MET1.96584316
13MAP3K91.86164503
14DAPK21.80883110
15ZAK1.66839584
16ARAF1.59403574
17MAP3K131.56581678
18PKN11.54130843
19BMX1.52511783
20STK38L1.41446266
21PTK2B1.40298941
22PIM21.39613953
23RAF11.37880512
24PDK21.36049917
25NME11.35872202
26EIF2AK11.26882570
27LATS11.26111528
28MAPK131.22684092
29MAP2K21.18507559
30NTRK31.07769009
31MOS1.07658425
32FES1.04428776
33CDK31.01650624
34JAK31.00364850
35VRK10.99301758
36MAP2K10.97848498
37WNK40.97608634
38CSF1R0.92375427
39ROCK10.83814589
40TLK10.82387282
41TGFBR10.81367900
42NEK90.79966018
43MST40.78280816
44PINK10.78073188
45CDC70.77838058
46KSR20.76823661
47EIF2AK30.76263413
48BRSK20.75022404
49NEK20.74488839
50STK390.73134129
51OXSR10.67953937
52PLK20.66408236
53PLK40.66164157
54CSNK1G20.61593672
55CAMK2A0.61372496
56MKNK20.59724982
57VRK20.59272976
58MKNK10.58813964
59CAMKK10.58347072
60PAK20.56552126
61PRKCG0.56532637
62ADRBK20.55521433
63TTK0.55046472
64PLK30.51571326
65PRKCI0.50117644
66FRK0.46653975
67ADRBK10.44947879
68GSK3A0.44490154
69BRAF0.43205010
70PLK10.42903587
71CSNK1G10.41972286
72INSRR0.40951700
73LATS20.39759662
74PDGFRB0.38471092
75CDK50.36601593
76PRKCZ0.35803835
77PAK60.35643932
78KSR10.33786332
79ABL10.32156837
80TNIK0.31186499
81CSNK1G30.27958305
82EGFR0.27320108
83PIM10.26665997
84DYRK20.25400619
85GRK70.23959003
86NEK60.22918746
87PBK0.22837851
88TYRO30.21167637
89CSNK2A10.20418767
90MELK0.20185410
91MAPK70.19285365
92DYRK1A0.19167110
93INSR0.17065251
94MAPK30.16927779
95LYN0.16290260
96NLK0.15814718
97CSNK1E0.15466351
98MAP3K70.15293015
99SIK20.14830223
100ROCK20.14116931

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006037.36982421
2Fatty acid biosynthesis_Homo sapiens_hsa000613.23162530
3Nicotine addiction_Homo sapiens_hsa050333.22086550
4Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.94424969
5Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.20459761
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.19434193
7PPAR signaling pathway_Homo sapiens_hsa033202.17311027
8Basal transcription factors_Homo sapiens_hsa030222.16704256
9Collecting duct acid secretion_Homo sapiens_hsa049662.14580429
10Protein export_Homo sapiens_hsa030602.13114903
11Nitrogen metabolism_Homo sapiens_hsa009102.08066337
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.00124392
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.96081159
14GABAergic synapse_Homo sapiens_hsa047271.95470164
15Phototransduction_Homo sapiens_hsa047441.92585877
16Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.73302775
17Morphine addiction_Homo sapiens_hsa050321.57515063
18Estrogen signaling pathway_Homo sapiens_hsa049151.47629582
19Ether lipid metabolism_Homo sapiens_hsa005651.42182371
20Arginine and proline metabolism_Homo sapiens_hsa003301.39641488
21Glycosaminoglycan degradation_Homo sapiens_hsa005311.38655743
22cAMP signaling pathway_Homo sapiens_hsa040241.33368846
23Oxidative phosphorylation_Homo sapiens_hsa001901.31589466
24ABC transporters_Homo sapiens_hsa020101.31383680
25Homologous recombination_Homo sapiens_hsa034401.31243579
26Cocaine addiction_Homo sapiens_hsa050301.30353655
27Selenocompound metabolism_Homo sapiens_hsa004501.28892043
28Propanoate metabolism_Homo sapiens_hsa006401.23100573
29Glutamatergic synapse_Homo sapiens_hsa047241.15225490
30Antigen processing and presentation_Homo sapiens_hsa046121.12586932
31Taste transduction_Homo sapiens_hsa047421.08122013
32Glycerolipid metabolism_Homo sapiens_hsa005611.07677314
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01030205
34Olfactory transduction_Homo sapiens_hsa047400.97296497
35Histidine metabolism_Homo sapiens_hsa003400.96936892
36Non-homologous end-joining_Homo sapiens_hsa034500.95137356
37Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.92139526
38Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.90031098
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.88760048
40Cell cycle_Homo sapiens_hsa041100.87728824
41Fatty acid metabolism_Homo sapiens_hsa012120.87449381
42Glycerophospholipid metabolism_Homo sapiens_hsa005640.86716017
43Fanconi anemia pathway_Homo sapiens_hsa034600.85379577
44TGF-beta signaling pathway_Homo sapiens_hsa043500.84555098
45Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.83547301
46Mineral absorption_Homo sapiens_hsa049780.83470175
47Tryptophan metabolism_Homo sapiens_hsa003800.82362977
48beta-Alanine metabolism_Homo sapiens_hsa004100.81544672
49Gastric acid secretion_Homo sapiens_hsa049710.80260672
50Butanoate metabolism_Homo sapiens_hsa006500.79811255
51Amphetamine addiction_Homo sapiens_hsa050310.79682325
52Folate biosynthesis_Homo sapiens_hsa007900.79404123
53Legionellosis_Homo sapiens_hsa051340.78359688
54Parkinsons disease_Homo sapiens_hsa050120.77169569
55Steroid hormone biosynthesis_Homo sapiens_hsa001400.76610124
56Serotonergic synapse_Homo sapiens_hsa047260.76141084
57Pyruvate metabolism_Homo sapiens_hsa006200.75380092
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74444355
59Fatty acid degradation_Homo sapiens_hsa000710.74168880
60Cardiac muscle contraction_Homo sapiens_hsa042600.74064120
61Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.71044804
62Dorso-ventral axis formation_Homo sapiens_hsa043200.70903513
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65890145
64Hippo signaling pathway_Homo sapiens_hsa043900.64461677
65Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.62990717
66Nucleotide excision repair_Homo sapiens_hsa034200.62507589
67Linoleic acid metabolism_Homo sapiens_hsa005910.59791356
68Ovarian steroidogenesis_Homo sapiens_hsa049130.59348961
69Tyrosine metabolism_Homo sapiens_hsa003500.59016510
70Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.58447335
71Vibrio cholerae infection_Homo sapiens_hsa051100.53346741
72alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47306988
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.47272312
74Peroxisome_Homo sapiens_hsa041460.46022509
75ECM-receptor interaction_Homo sapiens_hsa045120.44789867
76Calcium signaling pathway_Homo sapiens_hsa040200.44036517
77Bile secretion_Homo sapiens_hsa049760.42410968
78Huntingtons disease_Homo sapiens_hsa050160.40011171
79Renin-angiotensin system_Homo sapiens_hsa046140.39663901
80Steroid biosynthesis_Homo sapiens_hsa001000.38861617
81Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.38157970
82Arginine biosynthesis_Homo sapiens_hsa002200.37232450
83Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35824015
84Thyroid hormone synthesis_Homo sapiens_hsa049180.35802053
85Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34674164
86Notch signaling pathway_Homo sapiens_hsa043300.33635622
87DNA replication_Homo sapiens_hsa030300.33579634
88Synaptic vesicle cycle_Homo sapiens_hsa047210.31704688
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31495873
90Metabolic pathways_Homo sapiens_hsa011000.30299318
91Retinol metabolism_Homo sapiens_hsa008300.29853679
92Hedgehog signaling pathway_Homo sapiens_hsa043400.27640118
93Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.25016634
94Phospholipase D signaling pathway_Homo sapiens_hsa040720.24839440
95B cell receptor signaling pathway_Homo sapiens_hsa046620.24164764
96Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.22509018
97Chemokine signaling pathway_Homo sapiens_hsa040620.22283118
98Circadian entrainment_Homo sapiens_hsa047130.21561685
99Vitamin digestion and absorption_Homo sapiens_hsa049770.21171856
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20829089

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