ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.81902461
2	behavioral response to nicotine (GO:0035095)	4.79630943
3	water-soluble vitamin biosynthetic process (GO:0042364)	4.72163157
4	response to pheromone (GO:0019236)	4.59577070
5	DNA deamination (GO:0045006)	4.53376143
6	protein complex biogenesis (GO:0070271)	3.93717150
7	tryptophan catabolic process (GO:0006569)	3.72083319
8	indole-containing compound catabolic process (GO:0042436)	3.72083319
9	indolalkylamine catabolic process (GO:0046218)	3.72083319
10	mitochondrial respiratory chain complex assembly (GO:0033108)	3.62674460
11	cytochrome complex assembly (GO:0017004)	3.56444337
12	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.55123886
13	kidney morphogenesis (GO:0060993)	3.46870424
14	respiratory chain complex IV assembly (GO:0008535)	3.46522043
15	indolalkylamine metabolic process (GO:0006586)	3.45598798
16	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.41800008
17	sulfation (GO:0051923)	3.31283892
18	kynurenine metabolic process (GO:0070189)	3.26933214
19	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.25003888
20	NADH dehydrogenase complex assembly (GO:0010257)	3.25003888
21	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.25003888
22	DNA double-strand break processing (GO:0000729)	3.25001904
23	somite development (GO:0061053)	3.24512583
24	tryptophan metabolic process (GO:0006568)	3.12172062
25	neural tube formation (GO:0001841)	3.11192322
26	protein-cofactor linkage (GO:0018065)	3.10031966
27	piRNA metabolic process (GO:0034587)	3.08696083
28	axoneme assembly (GO:0035082)	3.07695668
29	otic vesicle formation (GO:0030916)	3.04749280
30	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.03093971
31	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.03093971
32	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.02089414
33	platelet dense granule organization (GO:0060155)	3.00745122
34	fucose catabolic process (GO:0019317)	3.00550762
35	L-fucose metabolic process (GO:0042354)	3.00550762
36	L-fucose catabolic process (GO:0042355)	3.00550762
37	regulation of cilium movement (GO:0003352)	3.00037182
38	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.96322246
39	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.92333395
40	ATP synthesis coupled proton transport (GO:0015986)	2.91489411
41	energy coupled proton transport, down electrochemical gradient (GO:0015985)	2.91489411
42	regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)	2.91019861
43	regulation of mitotic spindle checkpoint (GO:1903504)	2.91019861
44	cellular ketone body metabolic process (GO:0046950)	2.88296003
45	gamma-aminobutyric acid transport (GO:0015812)	2.88114311
46	regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:0045091	2.87878479
47	positive regulation of phosphoprotein phosphatase activity (GO:0032516)	2.84665533
48	indole-containing compound metabolic process (GO:0042430)	2.84386365
49	ketone body metabolic process (GO:1902224)	2.84057623
50	pseudouridine synthesis (GO:0001522)	2.83691261
51	primary amino compound metabolic process (GO:1901160)	2.81525881
52	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	2.79093987
53	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.77186504
54	cytidine deamination (GO:0009972)	2.76366975
55	cytidine metabolic process (GO:0046087)	2.76366975
56	cytidine catabolic process (GO:0006216)	2.76366975
57	cell proliferation in forebrain (GO:0021846)	2.75329458
58	intracellular protein transmembrane import (GO:0044743)	2.74350448
59	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	2.72501999
60	neuronal action potential (GO:0019228)	2.71583592
61	protein polyglutamylation (GO:0018095)	2.71380211
62	protein K6-linked ubiquitination (GO:0085020)	2.68006862
63	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.66898803
64	detection of light stimulus involved in sensory perception (GO:0050962)	2.66492849
65	detection of light stimulus involved in visual perception (GO:0050908)	2.66492849
66	serotonin metabolic process (GO:0042428)	2.66106536
67	nonmotile primary cilium assembly (GO:0035058)	2.63304174
68	regulation of nuclear cell cycle DNA replication (GO:0033262)	2.62766834
69	protein neddylation (GO:0045116)	2.62080470
70	transmission of nerve impulse (GO:0019226)	2.61720941
71	negative regulation of astrocyte differentiation (GO:0048712)	2.60789290
72	embryonic epithelial tube formation (GO:0001838)	2.60394433
73	negative regulation of telomere maintenance (GO:0032205)	2.56496183
74	negative regulation of transcription regulatory region DNA binding (GO:2000678)	2.56141996
75	protein localization to cilium (GO:0061512)	2.53601329
76	amine catabolic process (GO:0009310)	2.51978702
77	cellular biogenic amine catabolic process (GO:0042402)	2.51978702
78	lateral sprouting from an epithelium (GO:0060601)	2.50957392
79	regulation of meiosis I (GO:0060631)	2.50317697
80	electron transport chain (GO:0022900)	2.50248100
81	photoreceptor cell development (GO:0042461)	2.49920870
82	rRNA catabolic process (GO:0016075)	2.49181159
83	positive regulation of fatty acid transport (GO:2000193)	2.49110134
84	response to nitrosative stress (GO:0051409)	2.48324490
85	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.47715908
86	synaptic transmission, cholinergic (GO:0007271)	2.46944330
87	limb bud formation (GO:0060174)	2.46879305
88	regulation of mesoderm development (GO:2000380)	2.46403505
89	respiratory electron transport chain (GO:0022904)	2.46115812
90	epithelial tube formation (GO:0072175)	2.45150536
91	proteasome assembly (GO:0043248)	2.44557322
92	recombinational repair (GO:0000725)	2.42606961
93	DNA methylation involved in gamete generation (GO:0043046)	2.41465747
94	double-strand break repair via homologous recombination (GO:0000724)	2.40989110
95	peptidyl-histidine modification (GO:0018202)	2.40693517
96	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.40665397
97	retinal cone cell development (GO:0046549)	2.40466923
98	dopamine transport (GO:0015872)	2.40195594
99	epithelial cilium movement (GO:0003351)	2.39399194
100	protein K11-linked deubiquitination (GO:0035871)	2.38435290

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	3.67949954
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.36058976
3	VDR_22108803_ChIP-Seq_LS180_Human	2.91578216
4	GBX2_23144817_ChIP-Seq_PC3_Human	2.79567700
5	EZH2_22144423_ChIP-Seq_EOC_Human	2.63755092
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.59073678
7	IGF1R_20145208_ChIP-Seq_DFB_Human	2.48135765
8	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.48039300
9	FUS_26573619_Chip-Seq_HEK293_Human	2.26926886
10	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.22015315
11	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.19320391
12	FLI1_27457419_Chip-Seq_LIVER_Mouse	2.16608019
13	P300_19829295_ChIP-Seq_ESCs_Human	2.16066629
14	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.11942806
15	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.11797869
16	EWS_26573619_Chip-Seq_HEK293_Human	2.10756144
17	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.10159941
18	TAF15_26573619_Chip-Seq_HEK293_Human	2.08205554
19	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.05842357
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.88599841
21	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.88572606
22	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.88006282
23	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.84668520
24	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.81805723
25	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.75750507
26	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.68633425
27	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.59161156
28	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.58745968
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.57583499
30	BCAT_22108803_ChIP-Seq_LS180_Human	1.56822385
31	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.54165878
32	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.52653389
33	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.51511566
34	MYC_18940864_ChIP-ChIP_HL60_Human	1.50370113
35	SMAD4_21799915_ChIP-Seq_A2780_Human	1.48840715
36	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.47836989
37	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.47794236
38	TP53_22573176_ChIP-Seq_HFKS_Human	1.46313752
39	AR_21572438_ChIP-Seq_LNCaP_Human	1.46142933
40	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.42129190
41	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40176960
42	CBP_20019798_ChIP-Seq_JUKART_Human	1.40176960
43	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.39447137
44	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.39447137
45	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.39428965
46	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.38667343
47	AR_25329375_ChIP-Seq_VCAP_Human	1.38177650
48	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.38132755
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.37544717
50	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.37215688
51	STAT3_23295773_ChIP-Seq_U87_Human	1.36225254
52	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.35910261
53	IRF1_19129219_ChIP-ChIP_H3396_Human	1.34641050
54	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.34609319
55	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.34531993
56	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.34055348
57	RUNX2_22187159_ChIP-Seq_PCA_Human	1.32135913
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.31805271
59	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.30893860
60	SOX2_19829295_ChIP-Seq_ESCs_Human	1.30678153
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.30678153
62	RNF2_27304074_Chip-Seq_NSC_Mouse	1.30552978
63	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.30171046
64	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.28900128
65	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.28158679
66	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.27571812
67	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.27571812
68	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.27050209
69	ELK1_19687146_ChIP-ChIP_HELA_Human	1.26693896
70	TCF4_23295773_ChIP-Seq_U87_Human	1.26236139
71	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.24496908
72	REST_21632747_ChIP-Seq_MESCs_Mouse	1.24281309
73	TCF4_22108803_ChIP-Seq_LS180_Human	1.20933453
74	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.18383232
75	VDR_23849224_ChIP-Seq_CD4+_Human	1.17167959
76	HTT_18923047_ChIP-ChIP_STHdh_Human	1.17141924
77	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.16999784
78	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.13402957
79	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.11946081
80	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.11296754
81	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.11135705
82	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.10754240
83	P53_22387025_ChIP-Seq_ESCs_Mouse	1.09802558
84	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.09285612
85	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.09081392
86	NCOR_22424771_ChIP-Seq_293T_Human	1.09036804
87	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.08787764
88	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.08451420
89	CRX_20693478_ChIP-Seq_RETINA_Mouse	1.06112779
90	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.06035374
91	AR_20517297_ChIP-Seq_VCAP_Human	1.05571600
92	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05275195
93	RBPJ_22232070_ChIP-Seq_NCS_Mouse	1.02295352
94	STAT3_18555785_Chip-Seq_ESCs_Mouse	1.01923305
95	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	1.00645085
96	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.99810173
97	HOXB7_26014856_ChIP-Seq_BT474_Human	0.98249551
98	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.96536356
99	PRDM14_20953172_ChIP-Seq_ESCs_Human	0.96264859
100	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	0.95408760

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002837_dystrophic_cardiac_calcinosis	5.15382793
2	MP0003646_muscle_fatigue	4.92632485
3	MP0006292_abnormal_olfactory_placode	3.33377097
4	MP0008877_abnormal_DNA_methylation	2.80214862
5	MP0002102_abnormal_ear_morphology	2.65421851
6	MP0004147_increased_porphyrin_level	2.29383334
7	MP0003195_calcinosis	2.24688209
8	MP0003880_abnormal_central_pattern	2.21094483
9	MP0001485_abnormal_pinna_reflex	2.16072191
10	MP0005551_abnormal_eye_electrophysiolog	2.12424517
11	MP0005646_abnormal_pituitary_gland	2.02010527
12	MP0002736_abnormal_nociception_after	2.00202818
13	MP0003136_yellow_coat_color	1.93063584
14	MP0000372_irregular_coat_pigmentation	1.93030456
15	MP0001968_abnormal_touch/_nociception	1.91731323
16	MP0004885_abnormal_endolymph	1.91729571
17	MP0002876_abnormal_thyroid_physiology	1.88463229
18	MP0006072_abnormal_retinal_apoptosis	1.72435927
19	MP0003787_abnormal_imprinting	1.70656211
20	MP0008872_abnormal_physiological_respon	1.70573732
21	MP0009046_muscle_twitch	1.70032141
22	MP0000631_abnormal_neuroendocrine_gland	1.68767918
23	MP0002653_abnormal_ependyma_morphology	1.68134811
24	MP0001984_abnormal_olfaction	1.61845393
25	MP0002272_abnormal_nervous_system	1.61279484
26	MP0009745_abnormal_behavioral_response	1.58818425
27	MP0004133_heterotaxia	1.51817319
28	MP0002735_abnormal_chemical_nociception	1.50595634
29	MP0004142_abnormal_muscle_tone	1.50220968
30	MP0002163_abnormal_gland_morphology	1.47658484
31	MP0005645_abnormal_hypothalamus_physiol	1.44387206
32	MP0001486_abnormal_startle_reflex	1.43208069
33	MP0008789_abnormal_olfactory_epithelium	1.35765811
34	MP0005379_endocrine/exocrine_gland_phen	1.32665178
35	MP0005253_abnormal_eye_physiology	1.31729937
36	MP0003938_abnormal_ear_development	1.26514072
37	MP0003878_abnormal_ear_physiology	1.25189699
38	MP0005377_hearing/vestibular/ear_phenot	1.25189699
39	MP0003122_maternal_imprinting	1.19791148
40	MP0008775_abnormal_heart_ventricle	1.19785930
41	MP0005423_abnormal_somatic_nervous	1.18352823
42	MP0008875_abnormal_xenobiotic_pharmacok	1.17920637
43	MP0006276_abnormal_autonomic_nervous	1.15953108
44	MP0003011_delayed_dark_adaptation	1.15222445
45	MP0000049_abnormal_middle_ear	1.14813391
46	MP0003121_genomic_imprinting	1.12215446
47	MP0000569_abnormal_digit_pigmentation	1.10498687
48	MP0001970_abnormal_pain_threshold	1.08950221
49	MP0001986_abnormal_taste_sensitivity	1.08472570
50	MP0002638_abnormal_pupillary_reflex	1.06815527
51	MP0002277_abnormal_respiratory_mucosa	1.06596132
52	MP0000778_abnormal_nervous_system	1.06227045
53	MP0002733_abnormal_thermal_nociception	1.05883420
54	MP0002938_white_spotting	1.05384228
55	MP0005389_reproductive_system_phenotype	1.05134626
56	MP0001501_abnormal_sleep_pattern	1.04386842
57	MP0003283_abnormal_digestive_organ	1.04316703
58	MP0001529_abnormal_vocalization	1.04080888
59	MP0002734_abnormal_mechanical_nocicepti	1.04040658
60	MP0003137_abnormal_impulse_conducting	1.01946176
61	MP0002160_abnormal_reproductive_system	1.00882018
62	MP0000427_abnormal_hair_cycle	1.00175463
63	MP0008058_abnormal_DNA_repair	0.99958279
64	MP0002557_abnormal_social/conspecific_i	0.98359222
65	MP0001963_abnormal_hearing_physiology	0.97260808
66	MP0003567_abnormal_fetal_cardiomyocyte	0.97166560
67	MP0000026_abnormal_inner_ear	0.96918431
68	MP0002254_reproductive_system_inflammat	0.95935877
69	MP0005195_abnormal_posterior_eye	0.95122776
70	MP0002572_abnormal_emotion/affect_behav	0.94741349
71	MP0005174_abnormal_tail_pigmentation	0.94192921
72	MP0004742_abnormal_vestibular_system	0.93549141
73	MP0002234_abnormal_pharynx_morphology	0.93405040
74	MP0001905_abnormal_dopamine_level	0.93376420
75	MP0002064_seizures	0.93100911
76	MP0004130_abnormal_muscle_cell	0.90696804
77	MP0002693_abnormal_pancreas_physiology	0.88941903
78	MP0002752_abnormal_somatic_nervous	0.86667631
79	MP0004145_abnormal_muscle_electrophysio	0.85860946
80	MP0002751_abnormal_autonomic_nervous	0.85838077
81	MP0003937_abnormal_limbs/digits/tail_de	0.85667796
82	MP0005394_taste/olfaction_phenotype	0.84676025
83	MP0005499_abnormal_olfactory_system	0.84676025
84	MP0003635_abnormal_synaptic_transmissio	0.83564281
85	MP0002063_abnormal_learning/memory/cond	0.83057503
86	MP0003718_maternal_effect	0.82306558
87	MP0010386_abnormal_urinary_bladder	0.81857810
88	MP0002067_abnormal_sensory_capabilities	0.81684461
89	MP0003119_abnormal_digestive_system	0.81667842
90	MP0008995_early_reproductive_senescence	0.80698264
91	MP0009250_abnormal_appendicular_skeleto	0.80314562
92	MP0005410_abnormal_fertilization	0.79780509
93	MP0001919_abnormal_reproductive_system	0.79265726
94	MP0002095_abnormal_skin_pigmentation	0.77976631
95	MP0002282_abnormal_trachea_morphology	0.75698703
96	MP0005386_behavior/neurological_phenoty	0.75333486
97	MP0004924_abnormal_behavior	0.75333486
98	MP0002229_neurodegeneration	0.74397009
99	MP0002210_abnormal_sex_determination	0.72863963
100	MP0006036_abnormal_mitochondrial_physio	0.72542586

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.29606411
2	True hermaphroditism (HP:0010459)	4.13217543
3	Pancreatic fibrosis (HP:0100732)	4.08513121
4	Abnormality of midbrain morphology (HP:0002418)	3.80198190
5	Molar tooth sign on MRI (HP:0002419)	3.80198190
6	Congenital stationary night blindness (HP:0007642)	3.64749764
7	Septo-optic dysplasia (HP:0100842)	3.40795167
8	Nephronophthisis (HP:0000090)	3.32436837
9	Methylmalonic acidemia (HP:0002912)	3.08940041
10	Pendular nystagmus (HP:0012043)	3.05244855
11	Optic nerve hypoplasia (HP:0000609)	2.88755037
12	Abnormality of the renal cortex (HP:0011035)	2.77379812
13	Abnormality of the renal medulla (HP:0100957)	2.76512260
14	Acute necrotizing encephalopathy (HP:0006965)	2.71301268
15	Cystic liver disease (HP:0006706)	2.67795778
16	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.66303891
17	Medial flaring of the eyebrow (HP:0010747)	2.64448292
18	Abolished electroretinogram (ERG) (HP:0000550)	2.63300409
19	Mitochondrial inheritance (HP:0001427)	2.58590212
20	Methylmalonic aciduria (HP:0012120)	2.55364285
21	Progressive macrocephaly (HP:0004481)	2.54912743
22	Sclerocornea (HP:0000647)	2.48560504
23	Abnormal rod and cone electroretinograms (HP:0008323)	2.41012989
24	Increased CSF lactate (HP:0002490)	2.40369272
25	Acute encephalopathy (HP:0006846)	2.38498514
26	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.37264101
27	Decreased central vision (HP:0007663)	2.36563254
28	Type II lissencephaly (HP:0007260)	2.35409782
29	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.33876158
30	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.32271522
31	Abnormality of alanine metabolism (HP:0010916)	2.32271522
32	Hyperalaninemia (HP:0003348)	2.32271522
33	Renal cortical cysts (HP:0000803)	2.32105926
34	Increased hepatocellular lipid droplets (HP:0006565)	2.31978557
35	Furrowed tongue (HP:0000221)	2.26711524
36	Chronic hepatic failure (HP:0100626)	2.24258104
37	Anencephaly (HP:0002323)	2.22790620
38	Male pseudohermaphroditism (HP:0000037)	2.22769782
39	Abnormal mitochondria in muscle tissue (HP:0008316)	2.22402461
40	Attenuation of retinal blood vessels (HP:0007843)	2.20018840
41	Lipid accumulation in hepatocytes (HP:0006561)	2.19824300
42	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.16236065
43	Intestinal atresia (HP:0011100)	2.15868539
44	Abnormality of the labia minora (HP:0012880)	2.14872877
45	Keratoconus (HP:0000563)	2.14149488
46	Increased corneal curvature (HP:0100692)	2.14149488
47	Tubular atrophy (HP:0000092)	2.12628522
48	Genital tract atresia (HP:0001827)	2.09745087
49	Gait imbalance (HP:0002141)	2.08844062
50	Hepatocellular necrosis (HP:0001404)	2.07054390
51	Absent septum pellucidum (HP:0001331)	2.06177510
52	Congenital primary aphakia (HP:0007707)	2.05619430
53	Optic disc pallor (HP:0000543)	2.05542960
54	Hyperglycinemia (HP:0002154)	2.04762091
55	Chorioretinal atrophy (HP:0000533)	2.02716990
56	Congenital hepatic fibrosis (HP:0002612)	2.01538978
57	Vaginal atresia (HP:0000148)	2.01385750
58	Postaxial foot polydactyly (HP:0001830)	2.00476209
59	Aplasia/Hypoplasia of the spleen (HP:0010451)	1.99383533
60	Polydipsia (HP:0001959)	1.97389299
61	Abnormal drinking behavior (HP:0030082)	1.97389299
62	Hyperventilation (HP:0002883)	1.96839848
63	Nephrogenic diabetes insipidus (HP:0009806)	1.96085003
64	Abnormality of vitamin B metabolism (HP:0004340)	1.93549207
65	Gaze-evoked nystagmus (HP:0000640)	1.92496252
66	Hepatic necrosis (HP:0002605)	1.92347928
67	Decreased circulating renin level (HP:0003351)	1.90841236
68	3-Methylglutaconic aciduria (HP:0003535)	1.90376033
69	Short tibia (HP:0005736)	1.90102434
70	Asplenia (HP:0001746)	1.89437317
71	Congenital, generalized hypertrichosis (HP:0004540)	1.86710224
72	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	1.83749476
73	Abnormal number of erythroid precursors (HP:0012131)	1.81840396
74	Progressive inability to walk (HP:0002505)	1.81017264
75	Inability to walk (HP:0002540)	1.80512025
76	Birth length less than 3rd percentile (HP:0003561)	1.79861091
77	Bile duct proliferation (HP:0001408)	1.79346718
78	Abnormal biliary tract physiology (HP:0012439)	1.79346718
79	Abnormality of the vitamin B12 metabolism (HP:0004341)	1.79090867
80	Anophthalmia (HP:0000528)	1.78190942
81	Abnormality of the renal collecting system (HP:0004742)	1.78000115
82	Hypothermia (HP:0002045)	1.77099892
83	Absent thumb (HP:0009777)	1.76969697
84	Oligodactyly (hands) (HP:0001180)	1.76911220
85	Renal Fanconi syndrome (HP:0001994)	1.75791615
86	Preaxial hand polydactyly (HP:0001177)	1.75463360
87	Abnormality of the middle phalanges of the toes (HP:0010183)	1.73865515
88	Abnormality of serum amino acid levels (HP:0003112)	1.72491480
89	Small hand (HP:0200055)	1.71784511
90	Postaxial hand polydactyly (HP:0001162)	1.71272725
91	Dynein arm defect of respiratory motile cilia (HP:0012255)	1.69940570
92	Absent/shortened dynein arms (HP:0200106)	1.69940570
93	Abnormality of the middle phalanx of the 5th finger (HP:0004219)	1.69808798
94	Abnormality of urine glucose concentration (HP:0011016)	1.69474379
95	Glycosuria (HP:0003076)	1.69474379
96	Hyperglycinuria (HP:0003108)	1.68417403
97	Colon cancer (HP:0003003)	1.68147210
98	Broad-based gait (HP:0002136)	1.68067662
99	Cerebral edema (HP:0002181)	1.67293352
100	Polyuria (HP:0000103)	1.66904827

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.46644045
2	ADRBK2	2.89365901
3	MAP4K2	2.83468683
4	ZAK	2.82402905
5	BMPR1B	2.66678710
6	WNK3	2.59768512
7	CASK	2.44593361
8	GRK1	2.36767773
9	PINK1	2.36659611
10	TNIK	2.24752904
11	ACVR1B	2.03090190
12	NUAK1	1.85060802
13	MST4	1.82218854
14	TLK1	1.75385313
15	MAP3K4	1.65790002
16	STK39	1.57613098
17	INSRR	1.57572971
18	WNK4	1.55563896
19	MAPK13	1.53996881
20	MKNK2	1.50067839
21	OXSR1	1.48702177
22	MUSK	1.48403295
23	TRIM28	1.42321217
24	EPHA4	1.39987055
25	NME1	1.34176371
26	TXK	1.24857808
27	DAPK2	1.22000459
28	MAP2K7	1.20219214
29	FGFR2	1.19793540
30	VRK1	1.19356351
31	NTRK3	1.18335975
32	DYRK2	1.17407060
33	PLK2	1.16441392
34	PAK3	1.07127778
35	STK3	1.06698564
36	BCKDK	1.06267325
37	NEK1	0.95797412
38	PLK3	0.95741247
39	PRKCG	0.95009168
40	CAMKK2	0.93943611
41	CSNK1G2	0.91846108
42	PRKCE	0.91055197
43	ERBB3	0.87747724
44	STK16	0.87179988
45	TAOK3	0.86600917
46	PLK4	0.85672377
47	ADRBK1	0.84746001
48	MARK1	0.83807340
49	VRK2	0.83592134
50	EIF2AK3	0.82236075
51	PNCK	0.81268331
52	NTRK2	0.78512257
53	CSNK1G1	0.76667909
54	MKNK1	0.74490660
55	STK38L	0.74063061
56	TGFBR1	0.72024433
57	CSNK1G3	0.70842973
58	PTK2B	0.69123478
59	BCR	0.69079738
60	PHKG2	0.67467476
61	PHKG1	0.67467476
62	CDC7	0.62028938
63	WEE1	0.61972509
64	PLK1	0.61460482
65	TAF1	0.60196558
66	PRKCQ	0.60180809
67	CAMK1	0.59496250
68	TNK2	0.57702836
69	CSNK1A1	0.56889970
70	CAMK2A	0.55133749
71	BRSK2	0.55053442
72	MAP3K9	0.54475102
73	NEK2	0.54063694
74	PRKACA	0.52817678
75	PKN1	0.52340502
76	FER	0.51303076
77	TIE1	0.51015218
78	BUB1	0.51000294
79	CSNK1A1L	0.50005638
80	PASK	0.49074342
81	IRAK1	0.48509441
82	EPHA3	0.47437941
83	PIK3CA	0.46704956
84	TEC	0.45063663
85	PDK2	0.43648988
86	RPS6KA5	0.42356464
87	RPS6KA4	0.42309496
88	PRKCA	0.41565418
89	OBSCN	0.41197326
90	MAP2K6	0.40031748
91	GRK7	0.40028333
92	ATR	0.39668468
93	CDK3	0.39581612
94	NLK	0.38935599
95	PRKCI	0.35472598
96	PRKCH	0.34818419
97	STK11	0.33464842
98	LATS1	0.32673018
99	LIMK1	0.32028134
100	PRKCZ	0.29893148

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.11081755
2	Protein export_Homo sapiens_hsa03060	2.54209565
3	Phototransduction_Homo sapiens_hsa04744	2.51338922
4	Parkinsons disease_Homo sapiens_hsa05012	2.42574420
5	Homologous recombination_Homo sapiens_hsa03440	2.23578361
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.18694338
7	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.15655304
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.14458838
9	RNA polymerase_Homo sapiens_hsa03020	2.12620606
10	Butanoate metabolism_Homo sapiens_hsa00650	2.02859973
11	Nicotine addiction_Homo sapiens_hsa05033	1.97019080
12	Nitrogen metabolism_Homo sapiens_hsa00910	1.96779411
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.94028097
14	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.91719127
15	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.86106993
16	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.79114905
17	Proteasome_Homo sapiens_hsa03050	1.72733384
18	Cardiac muscle contraction_Homo sapiens_hsa04260	1.66262877
19	Huntingtons disease_Homo sapiens_hsa05016	1.62757642
20	Basal transcription factors_Homo sapiens_hsa03022	1.62319540
21	Fanconi anemia pathway_Homo sapiens_hsa03460	1.61151567
22	Caffeine metabolism_Homo sapiens_hsa00232	1.61064342
23	Tryptophan metabolism_Homo sapiens_hsa00380	1.60393758
24	Alzheimers disease_Homo sapiens_hsa05010	1.59113525
25	RNA degradation_Homo sapiens_hsa03018	1.57672485
26	Propanoate metabolism_Homo sapiens_hsa00640	1.49790012
27	Ether lipid metabolism_Homo sapiens_hsa00565	1.47762490
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.47462553
29	One carbon pool by folate_Homo sapiens_hsa00670	1.45668620
30	Ribosome_Homo sapiens_hsa03010	1.44933518
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42125182
32	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.41476086
33	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.40654145
34	Chemical carcinogenesis_Homo sapiens_hsa05204	1.37734027
35	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.34546463
36	Peroxisome_Homo sapiens_hsa04146	1.32433348
37	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.32382100
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.30457111
39	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.24320601
40	Retinol metabolism_Homo sapiens_hsa00830	1.23908314
41	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.21468220
42	Taste transduction_Homo sapiens_hsa04742	1.18208804
43	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.17870289
44	Collecting duct acid secretion_Homo sapiens_hsa04966	1.17101746
45	Selenocompound metabolism_Homo sapiens_hsa00450	1.16102022
46	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.12075938
47	Olfactory transduction_Homo sapiens_hsa04740	1.09173949
48	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.04198325
49	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.01727947
50	Morphine addiction_Homo sapiens_hsa05032	1.00351903
51	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.93865391
52	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93245847
53	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.89195660
54	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.85092732
55	Insulin secretion_Homo sapiens_hsa04911	0.83450089
56	Sulfur metabolism_Homo sapiens_hsa00920	0.82918979
57	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.82850435
58	ABC transporters_Homo sapiens_hsa02010	0.82262453
59	Serotonergic synapse_Homo sapiens_hsa04726	0.81407466
60	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80744548
61	GABAergic synapse_Homo sapiens_hsa04727	0.80644073
62	Purine metabolism_Homo sapiens_hsa00230	0.80527950
63	Glutamatergic synapse_Homo sapiens_hsa04724	0.80046070
64	Primary immunodeficiency_Homo sapiens_hsa05340	0.78911211
65	Nucleotide excision repair_Homo sapiens_hsa03420	0.77452846
66	Glycerolipid metabolism_Homo sapiens_hsa00561	0.77421964
67	Metabolic pathways_Homo sapiens_hsa01100	0.74066456
68	Regulation of autophagy_Homo sapiens_hsa04140	0.71965986
69	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.69463663
70	Fat digestion and absorption_Homo sapiens_hsa04975	0.67818196
71	Fatty acid elongation_Homo sapiens_hsa00062	0.67048325
72	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.65135908
73	Non-homologous end-joining_Homo sapiens_hsa03450	0.62796515
74	Circadian entrainment_Homo sapiens_hsa04713	0.62657084
75	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.62094250
76	Pyrimidine metabolism_Homo sapiens_hsa00240	0.61239261
77	Mineral absorption_Homo sapiens_hsa04978	0.59499087
78	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.59458161
79	Mismatch repair_Homo sapiens_hsa03430	0.57646357
80	RNA transport_Homo sapiens_hsa03013	0.57392750
81	Steroid biosynthesis_Homo sapiens_hsa00100	0.55309852
82	Folate biosynthesis_Homo sapiens_hsa00790	0.55053732
83	Pyruvate metabolism_Homo sapiens_hsa00620	0.54426219
84	Fatty acid degradation_Homo sapiens_hsa00071	0.53153109
85	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50952340
86	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.50680372
87	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.49800821
88	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.49060582
89	Calcium signaling pathway_Homo sapiens_hsa04020	0.46310538
90	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.45234918
91	beta-Alanine metabolism_Homo sapiens_hsa00410	0.43823941
92	Sulfur relay system_Homo sapiens_hsa04122	0.41513305
93	Glutathione metabolism_Homo sapiens_hsa00480	0.40802041
94	Salivary secretion_Homo sapiens_hsa04970	0.37977661
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.37352578
96	Basal cell carcinoma_Homo sapiens_hsa05217	0.37325833
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.36874353
98	Histidine metabolism_Homo sapiens_hsa00340	0.36667320
99	Spliceosome_Homo sapiens_hsa03040	0.35044703
100	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.34060492

CTSLP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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