ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	eosinophil chemotaxis (GO:0048245)	7.99812290
2	eosinophil migration (GO:0072677)	7.16523404
3	melanin biosynthetic process (GO:0042438)	7.15496725
4	proteasome assembly (GO:0043248)	6.48203160
5	secondary metabolite biosynthetic process (GO:0044550)	6.46634995
6	platelet dense granule organization (GO:0060155)	6.38884625
7	melanin metabolic process (GO:0006582)	6.27580075
8	positive regulation of cAMP-mediated signaling (GO:0043950)	5.34516513
9	signal peptide processing (GO:0006465)	5.21982678
10	melanosome organization (GO:0032438)	5.11622037
11	pigment granule organization (GO:0048753)	4.72934531
12	endosome to melanosome transport (GO:0035646)	4.40613243
13	endosome to pigment granule transport (GO:0043485)	4.40613243
14	peroxisome fission (GO:0016559)	4.35407273
15	melanosome transport (GO:0032402)	4.18344185
16	establishment of melanosome localization (GO:0032401)	4.17031518
17	pigment granule transport (GO:0051904)	4.15861243
18	establishment of pigment granule localization (GO:0051905)	4.14713603
19	negative regulation of tumor necrosis factor-mediated signaling pathway (GO:0010804)	3.99912598
20	regulation of integrin-mediated signaling pathway (GO:2001044)	3.96687514
21	melanosome localization (GO:0032400)	3.96508320
22	pigment granule localization (GO:0051875)	3.95196765
23	anterograde synaptic vesicle transport (GO:0048490)	3.90268847
24	intracellular pH reduction (GO:0051452)	3.90187904
25	cullin deneddylation (GO:0010388)	3.86083355
26	regulation of nitric-oxide synthase biosynthetic process (GO:0051769)	3.78116132
27	cellular response to ethanol (GO:0071361)	3.70054952
28	protein deneddylation (GO:0000338)	3.65524505
29	lipopolysaccharide biosynthetic process (GO:0009103)	3.63162746
30	regulation of spindle organization (GO:0090224)	3.57787806
31	respiratory chain complex IV assembly (GO:0008535)	3.55155986
32	pyrimidine nucleoside salvage (GO:0043097)	3.54049925
33	pyrimidine-containing compound salvage (GO:0008655)	3.54049925
34	regulation of mononuclear cell migration (GO:0071675)	3.52273916
35	regulation of mitotic spindle organization (GO:0060236)	3.49281984
36	cellular response to zinc ion (GO:0071294)	3.48766112
37	pigment biosynthetic process (GO:0046148)	3.47699254
38	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	3.39323432
39	negative regulation of JUN kinase activity (GO:0043508)	3.29336029
40	histone H3-K9 demethylation (GO:0033169)	3.27766359
41	retinal rod cell development (GO:0046548)	3.27076942
42	anterograde axon cargo transport (GO:0008089)	3.27026769
43	C-terminal protein lipidation (GO:0006501)	3.26374037
44	pH reduction (GO:0045851)	3.25969012
45	pigment metabolic process (GO:0042440)	3.21149711
46	inner mitochondrial membrane organization (GO:0007007)	3.19216643
47	folic acid transport (GO:0015884)	3.14506151
48	lipopolysaccharide metabolic process (GO:0008653)	3.10981075
49	protein complex biogenesis (GO:0070271)	3.08283949
50	nucleotide transmembrane transport (GO:1901679)	3.06764019
51	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.04312962
52	NADH dehydrogenase complex assembly (GO:0010257)	3.04312962
53	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.04312962
54	phenol-containing compound biosynthetic process (GO:0046189)	3.04015691
55	male meiosis I (GO:0007141)	2.98393037
56	regulation of cilium movement (GO:0003352)	2.94376639
57	developmental pigmentation (GO:0048066)	2.94178060
58	C-terminal protein amino acid modification (GO:0018410)	2.90925943
59	branched-chain amino acid catabolic process (GO:0009083)	2.88882070
60	mitochondrial respiratory chain complex assembly (GO:0033108)	2.87599481
61	regulation of attachment of spindle microtubules to kinetochore (GO:0051988)	2.87424131
62	mitotic metaphase plate congression (GO:0007080)	2.83541886
63	acrosome reaction (GO:0007340)	2.82386927
64	purine ribonucleotide transport (GO:0015868)	2.79648992
65	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	2.78874157
66	negative regulation of chemokine production (GO:0032682)	2.78415989
67	piRNA metabolic process (GO:0034587)	2.77681383
68	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.77068519
69	synapsis (GO:0007129)	2.76660215
70	cytochrome complex assembly (GO:0017004)	2.76501696
71	positive regulation of p38MAPK cascade (GO:1900745)	2.75954435
72	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.75764347
73	tyrosine metabolic process (GO:0006570)	2.73922615
74	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	2.71883967
75	negative regulation of interleukin-1 beta production (GO:0032691)	2.71515352
76	cellular response to thyroid hormone stimulus (GO:0097067)	2.70761267
77	ribonucleoprotein complex disassembly (GO:0032988)	2.69953572
78	regulation of cellular amino acid metabolic process (GO:0006521)	2.68159508
79	glutathione derivative metabolic process (GO:1901685)	2.65809567
80	glutathione derivative biosynthetic process (GO:1901687)	2.65809567
81	regulation of macrophage chemotaxis (GO:0010758)	2.64798519
82	regulation of cAMP-mediated signaling (GO:0043949)	2.64634408
83	metaphase plate congression (GO:0051310)	2.59716567
84	auditory receptor cell stereocilium organization (GO:0060088)	2.59297705
85	histone mRNA metabolic process (GO:0008334)	2.57974603
86	heme metabolic process (GO:0042168)	2.57279999
87	lactate metabolic process (GO:0006089)	2.56646716
88	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.55943690
89	nucleoside transmembrane transport (GO:1901642)	2.55674163
90	transcription from mitochondrial promoter (GO:0006390)	2.55194562
91	regulation of intracellular pH (GO:0051453)	2.54769072
92	protein targeting to peroxisome (GO:0006625)	2.53572326
93	establishment of protein localization to peroxisome (GO:0072663)	2.53572326
94	protein localization to peroxisome (GO:0072662)	2.53572326
95	positive regulation of mitochondrial fission (GO:0090141)	2.53389234
96	amyloid precursor protein catabolic process (GO:0042987)	2.52615277
97	heme biosynthetic process (GO:0006783)	2.51615078
98	intracellular protein transmembrane import (GO:0044743)	2.49888479
99	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.48924386
100	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	2.48476028

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.39701698
2	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.26292732
3	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	4.14665312
4	EST1_17652178_ChIP-ChIP_JURKAT_Human	2.94020209
5	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	2.84345690
6	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.75979728
7	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	2.55796120
8	ELK1_19687146_ChIP-ChIP_HELA_Human	2.36155755
9	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.33695092
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	2.29425816
11	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.27073003
12	VDR_22108803_ChIP-Seq_LS180_Human	2.27010956
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.26813312
14	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	2.24663167
15	CREB1_15753290_ChIP-ChIP_HEK293T_Human	2.18331173
16	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.17128182
17	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.16199485
18	VDR_23849224_ChIP-Seq_CD4+_Human	2.08435233
19	EGR1_23403033_ChIP-Seq_LIVER_Mouse	2.07614940
20	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.04869525
21	TFEB_21752829_ChIP-Seq_HELA_Human	1.92436322
22	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	1.88818138
23	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.78218100
24	GATA1_22025678_ChIP-Seq_K562_Human	1.68189075
25	FOXP3_21729870_ChIP-Seq_TREG_Human	1.61666502
26	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.60124702
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.54666306
28	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.53191624
29	ZNF274_21170338_ChIP-Seq_K562_Hela	1.53057567
30	P300_19829295_ChIP-Seq_ESCs_Human	1.50964604
31	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	1.50513319
32	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.46440492
33	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.45312372
34	TP53_22573176_ChIP-Seq_HFKS_Human	1.42541060
35	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.41390423
36	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.40152841
37	IRF1_21803131_ChIP-Seq_MONOCYTES_Human	1.37527634
38	ER_23166858_ChIP-Seq_MCF-7_Human	1.33909106
39	GABP_19822575_ChIP-Seq_HepG2_Human	1.33653740
40	GBX2_23144817_ChIP-Seq_PC3_Human	1.29911456
41	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.29832935
42	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.26778441
43	TCF4_22108803_ChIP-Seq_LS180_Human	1.26360067
44	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.24465626
45	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.24465626
46	DCP1A_22483619_ChIP-Seq_HELA_Human	1.23400833
47	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.23160331
48	EWS_26573619_Chip-Seq_HEK293_Human	1.23145754
49	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.20856810
50	AR_20517297_ChIP-Seq_VCAP_Human	1.20075516
51	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.18835233
52	AR_25329375_ChIP-Seq_VCAP_Human	1.18649770
53	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.17792909
54	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.17311901
55	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.13609358
56	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.12127335
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.12115954
58	IGF1R_20145208_ChIP-Seq_DFB_Human	1.11389585
59	STAT1_20625510_ChIP-Seq_HELA_Human	1.11344899
60	HOXB7_26014856_ChIP-Seq_BT474_Human	1.10729246
61	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.10358542
62	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	1.09986140
63	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.08124161
64	RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse	1.08034799
65	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.08006401
66	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.07014706
67	NCOR_22424771_ChIP-Seq_293T_Human	1.06446031
68	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	1.06000242
69	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.05333824
70	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.04404905
71	CDX2_22108803_ChIP-Seq_LS180_Human	1.03711966
72	SOX2_19829295_ChIP-Seq_ESCs_Human	1.03321633
73	NANOG_19829295_ChIP-Seq_ESCs_Human	1.03321633
74	FUS_26573619_Chip-Seq_HEK293_Human	1.02067723
75	SMAD4_21799915_ChIP-Seq_A2780_Human	1.02018322
76	CBP_20019798_ChIP-Seq_JUKART_Human	1.00632113
77	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.00632113
78	MYCN_18555785_ChIP-Seq_MESCs_Mouse	0.99823236
79	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.99356635
80	MYC_18358816_ChIP-ChIP_MESCs_Mouse	0.99018524
81	FOXA1_21572438_ChIP-Seq_LNCaP_Human	0.97949491
82	MYC_18940864_ChIP-ChIP_HL60_Human	0.97341039
83	RBPJ_21746931_ChIP-Seq_IB4_Human	0.96750199
84	Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse	0.95606230
85	GATA3_26560356_Chip-Seq_TH1_Human	0.93291810
86	PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse	0.93069809
87	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.92787574
88	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	0.91285776
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.90723368
90	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	0.90215505
91	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.89870888
92	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	0.89684692
93	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.89190795
94	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.89093680
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.88006584
96	MYC_19829295_ChIP-Seq_ESCs_Human	0.85247242
97	BCAT_22108803_ChIP-Seq_LS180_Human	0.84633761
98	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	0.84597744
99	ETV1_20927104_ChIP-Seq_GIST48_Human	0.84024357
100	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.83669173

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000372_irregular_coat_pigmentation	6.25918071
2	MP0003136_yellow_coat_color	4.41756158
3	MP0005075_abnormal_melanosome_morpholog	4.29827152
4	MP0003806_abnormal_nucleotide_metabolis	3.96830346
5	MP0005408_hypopigmentation	3.93597299
6	MP0003950_abnormal_plasma_membrane	3.85537950
7	MP0000015_abnormal_ear_pigmentation	3.71296715
8	MP0003646_muscle_fatigue	3.40038977
9	MP0005171_absent_coat_pigmentation	3.38359811
10	MP0002095_abnormal_skin_pigmentation	3.10741717
11	MP0000371_diluted_coat_color	2.67686001
12	MP0006082_CNS_inflammation	2.65722686
13	MP0005174_abnormal_tail_pigmentation	2.41344897
14	MP0002090_abnormal_vision	2.27452583
15	MP0004233_abnormal_muscle_weight	2.14534920
16	MP0001324_abnormal_eye_pigmentation	2.09146869
17	MP0004381_abnormal_hair_follicle	1.99589342
18	MP0003186_abnormal_redox_activity	1.97561486
19	MP0001984_abnormal_olfaction	1.95496720
20	MP0008877_abnormal_DNA_methylation	1.92657781
21	MP0000569_abnormal_digit_pigmentation	1.83686797
22	MP0006035_abnormal_mitochondrial_morpho	1.83303911
23	MP0006036_abnormal_mitochondrial_physio	1.81616808
24	MP0004147_increased_porphyrin_level	1.71118213
25	MP0002102_abnormal_ear_morphology	1.65300764
26	MP0002075_abnormal_coat/hair_pigmentati	1.60719315
27	MP0010678_abnormal_skin_adnexa	1.56057965
28	MP0009697_abnormal_copulation	1.55682098
29	MP0003878_abnormal_ear_physiology	1.52788528
30	MP0005377_hearing/vestibular/ear_phenot	1.52788528
31	MP0000749_muscle_degeneration	1.52716670
32	MP0005410_abnormal_fertilization	1.49567000
33	MP0005551_abnormal_eye_electrophysiolog	1.48383135
34	MP0000647_abnormal_sebaceous_gland	1.46925091
35	MP0003191_abnormal_cellular_cholesterol	1.42868504
36	MP0006054_spinal_hemorrhage	1.41065419
37	MP0001186_pigmentation_phenotype	1.40406013
38	MP0008058_abnormal_DNA_repair	1.35598743
39	MP0005253_abnormal_eye_physiology	1.31847597
40	MP0010094_abnormal_chromosome_stability	1.30690426
41	MP0003172_abnormal_lysosome_physiology	1.30180073
42	MP0000358_abnormal_cell_content/	1.24202180
43	MP0002653_abnormal_ependyma_morphology	1.22961385
44	MP0005197_abnormal_uvea_morphology	1.20840684
45	MP0002148_abnormal_hypersensitivity_rea	1.19644678
46	MP0005257_abnormal_intraocular_pressure	1.18403269
47	MP0001986_abnormal_taste_sensitivity	1.15612507
48	MP0005058_abnormal_lysosome_morphology	1.12528566
49	MP0003718_maternal_effect	1.11356919
50	MP0000383_abnormal_hair_follicle	1.10738000
51	MP0000427_abnormal_hair_cycle	1.09019376
52	MP0003656_abnormal_erythrocyte_physiolo	1.07784855
53	MP0002229_neurodegeneration	1.07531460
54	MP0003195_calcinosis	1.06060073
55	MP0005423_abnormal_somatic_nervous	1.05748698
56	MP0002938_white_spotting	1.01973324
57	MP0000538_abnormal_urinary_bladder	1.01225438
58	MP0009785_altered_susceptibility_to	1.00628773
59	MP0009840_abnormal_foam_cell	0.91497259
60	MP0009764_decreased_sensitivity_to	0.90567809
61	MP0006072_abnormal_retinal_apoptosis	0.90357073
62	MP0000343_altered_response_to	0.88449897
63	MP0008875_abnormal_xenobiotic_pharmacok	0.87576319
64	MP0003252_abnormal_bile_duct	0.87155302
65	MP0003890_abnormal_embryonic-extraembry	0.83808334
66	MP0002269_muscular_atrophy	0.82270915
67	MP0005647_abnormal_sex_gland	0.81786163
68	MP0005085_abnormal_gallbladder_physiolo	0.81417437
69	MP0005310_abnormal_salivary_gland	0.80717431
70	MP0005360_urolithiasis	0.80645380
71	MP0003183_abnormal_peptide_metabolism	0.80572418
72	MP0005319_abnormal_enzyme/_coenzyme	0.79792704
73	MP0004885_abnormal_endolymph	0.77966416
74	MP0001764_abnormal_homeostasis	0.76016156
75	MP0003693_abnormal_embryo_hatching	0.74451448
76	MP0010386_abnormal_urinary_bladder	0.73706676
77	MP0008932_abnormal_embryonic_tissue	0.72693384
78	MP0009046_muscle_twitch	0.71330887
79	MP0005671_abnormal_response_to	0.71193479
80	MP0001929_abnormal_gametogenesis	0.70863710
81	MP0001485_abnormal_pinna_reflex	0.70163207
82	MP0008260_abnormal_autophagy	0.68309341
83	MP0003880_abnormal_central_pattern	0.66335227
84	MP0002282_abnormal_trachea_morphology	0.65259899
85	MP0000920_abnormal_myelination	0.61532989
86	MP0008469_abnormal_protein_level	0.60030987
87	MP0001502_abnormal_circadian_rhythm	0.57946519
88	MP0001963_abnormal_hearing_physiology	0.57877972
89	MP0002272_abnormal_nervous_system	0.57377378
90	MP0001529_abnormal_vocalization	0.56550942
91	MP0002139_abnormal_hepatobiliary_system	0.56546346
92	MP0002177_abnormal_outer_ear	0.54648812
93	MP0005332_abnormal_amino_acid	0.53686968
94	MP0001756_abnormal_urination	0.53078672
95	MP0003698_abnormal_male_reproductive	0.52966196
96	MP0003077_abnormal_cell_cycle	0.51857668
97	MP0004043_abnormal_pH_regulation	0.50771882
98	MP0004957_abnormal_blastocyst_morpholog	0.50281219
99	MP0009333_abnormal_splenocyte_physiolog	0.50081514
100	MP0002210_abnormal_sex_determination	0.50038603

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Aplasia/Hypoplasia of the fovea (HP:0008060)	5.38960273
2	Hypoplasia of the fovea (HP:0007750)	5.38960273
3	Aplasia/Hypoplasia of the macula (HP:0008059)	4.78638504
4	Ocular albinism (HP:0001107)	4.73706559
5	Aplasia/Hypoplasia affecting the retina (HP:0008061)	4.48009853
6	Abnormality of the fovea (HP:0000493)	4.33997842
7	Iris hypopigmentation (HP:0007730)	4.24463411
8	Albinism (HP:0001022)	3.68770065
9	Malnutrition (HP:0004395)	3.38794604
10	Abnormal gallbladder physiology (HP:0012438)	3.14615773
11	Cholecystitis (HP:0001082)	3.14615773
12	Increased CSF lactate (HP:0002490)	3.14575389
13	Abnormality of glycolipid metabolism (HP:0010969)	3.06934791
14	Abnormality of liposaccharide metabolism (HP:0010968)	3.06934791
15	Abnormality of glycosphingolipid metabolism (HP:0004343)	3.06934791
16	Increased hepatocellular lipid droplets (HP:0006565)	2.98398161
17	Acute necrotizing encephalopathy (HP:0006965)	2.93289454
18	Aplastic anemia (HP:0001915)	2.92736180
19	Generalized hypopigmentation (HP:0007513)	2.92205745
20	Abnormality of aromatic amino acid family metabolism (HP:0004338)	2.91668661
21	Nephrogenic diabetes insipidus (HP:0009806)	2.91118583
22	Congenital primary aphakia (HP:0007707)	2.90949137
23	Neoplasm of head and neck (HP:0012288)	2.88998018
24	Esophageal neoplasm (HP:0100751)	2.88998018
25	Abnormal mitochondria in muscle tissue (HP:0008316)	2.88310670
26	Increased serum pyruvate (HP:0003542)	2.88250780
27	Hypokinesia (HP:0002375)	2.86330427
28	Medial flaring of the eyebrow (HP:0010747)	2.83491972
29	Blue irides (HP:0000635)	2.81332097
30	Mitochondrial inheritance (HP:0001427)	2.79965805
31	Gait imbalance (HP:0002141)	2.78150312
32	Renal Fanconi syndrome (HP:0001994)	2.74034687
33	Decreased central vision (HP:0007663)	2.71508654
34	Patchy hypopigmentation of hair (HP:0011365)	2.66490878
35	Abnormality of glycolysis (HP:0004366)	2.66196136
36	Hepatocellular necrosis (HP:0001404)	2.66180724
37	Congenital stationary night blindness (HP:0007642)	2.64336356
38	Hepatic necrosis (HP:0002605)	2.60312899
39	Progressive neurologic deterioration (HP:0002344)	2.58015230
40	3-Methylglutaconic aciduria (HP:0003535)	2.56977391
41	Lipid accumulation in hepatocytes (HP:0006561)	2.55270348
42	Hypothermia (HP:0002045)	2.51967219
43	Acute encephalopathy (HP:0006846)	2.45092808
44	Microvesicular hepatic steatosis (HP:0001414)	2.42621068
45	Bile duct proliferation (HP:0001408)	2.38963835
46	Abnormal biliary tract physiology (HP:0012439)	2.38963835
47	Vacuolated lymphocytes (HP:0001922)	2.34696826
48	Ulnar claw (HP:0001178)	2.34012677
49	Increased intramyocellular lipid droplets (HP:0012240)	2.33625097
50	Progressive macrocephaly (HP:0004481)	2.29086517
51	Exertional dyspnea (HP:0002875)	2.25389268
52	Hypopigmentation of the fundus (HP:0007894)	2.22148953
53	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.15103424
54	Horizontal nystagmus (HP:0000666)	2.14580572
55	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.14284608
56	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.14284608
57	Cholelithiasis (HP:0001081)	2.13924794
58	Pancreatic cysts (HP:0001737)	2.12954695
59	Astigmatism (HP:0000483)	2.10127808
60	Metaphyseal dysplasia (HP:0100255)	2.06395700
61	Respiratory difficulties (HP:0002880)	2.04480750
62	Abnormal gallbladder morphology (HP:0012437)	2.04015592
63	White forelock (HP:0002211)	2.03762324
64	Increased serum lactate (HP:0002151)	2.03053530
65	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.00147743
66	Generalized aminoaciduria (HP:0002909)	1.99584820
67	Freckling (HP:0001480)	1.96840698
68	Abnormal auditory evoked potentials (HP:0006958)	1.96789352
69	Prostate neoplasm (HP:0100787)	1.94830636
70	Abnormality of small intestinal villus morphology (HP:0011472)	1.93885957
71	Villous atrophy (HP:0011473)	1.93885957
72	Mutism (HP:0002300)	1.92574127
73	Delayed CNS myelination (HP:0002188)	1.92573266
74	Methylmalonic aciduria (HP:0012120)	1.91638076
75	Atrophy/Degeneration involving motor neurons (HP:0007373)	1.91098916
76	Genital tract atresia (HP:0001827)	1.87628541
77	Lactic acidosis (HP:0003128)	1.87175421
78	Tubulointerstitial abnormality (HP:0001969)	1.83826232
79	Cerebral edema (HP:0002181)	1.83711281
80	Vaginal atresia (HP:0000148)	1.83365114
81	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.82552141
82	Glycosuria (HP:0003076)	1.81874348
83	Abnormality of urine glucose concentration (HP:0011016)	1.81874348
84	Tubular atrophy (HP:0000092)	1.81559286
85	Spastic paraparesis (HP:0002313)	1.81304016
86	Tubulointerstitial nephritis (HP:0001970)	1.81274163
87	Abnormality of renal resorption (HP:0011038)	1.80885020
88	Pustule (HP:0200039)	1.80802544
89	Respiratory failure (HP:0002878)	1.80162654
90	Adrenal hypoplasia (HP:0000835)	1.78522804
91	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.76889182
92	Posterior subcapsular cataract (HP:0007787)	1.76047455
93	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.74835549
94	True hermaphroditism (HP:0010459)	1.74808167
95	Abnormal drinking behavior (HP:0030082)	1.74727486
96	Polydipsia (HP:0001959)	1.74727486
97	Abnormality of the anterior horn cell (HP:0006802)	1.74006679
98	Degeneration of anterior horn cells (HP:0002398)	1.74006679
99	Agnosia (HP:0010524)	1.73194612
100	Systemic lupus erythematosus (HP:0002725)	1.73010201

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EIF2AK3	5.19165571
2	EIF2AK1	4.38971071
3	PDK2	3.27404155
4	NEK1	3.26336043
5	BLK	3.24927463
6	STK16	3.11937940
7	MST1R	2.78475033
8	BMPR2	2.66187122
9	SRPK1	2.59281055
10	MAP3K12	2.55448139
11	ERBB3	2.38138420
12	PLK2	2.15828337
13	PBK	2.03701401
14	BMPR1B	1.90770417
15	WEE1	1.87607335
16	BCR	1.82184196
17	MAP4K2	1.81063718
18	FRK	1.68951405
19	LATS2	1.65498098
20	PLK4	1.60492116
21	PLK3	1.50269404
22	ZAK	1.46605034
23	EIF2AK2	1.33240918
24	CSNK1G3	1.26348026
25	MAP3K3	1.25747045
26	NEK9	1.18270338
27	CSNK1G1	1.11210123
28	TTK	1.09937486
29	TRIM28	1.08995563
30	CSNK1G2	1.02313914
31	CSNK1A1L	1.01585990
32	PRKCH	1.00018699
33	FER	0.97061657
34	WNK3	0.94307362
35	LIMK1	0.93511713
36	PLK1	0.93273878
37	TGFBR2	0.92151971
38	BCKDK	0.90402596
39	STK38L	0.90299669
40	MET	0.83545325
41	PIK3CA	0.81770570
42	BUB1	0.80181454
43	ADRBK2	0.77409987
44	TNIK	0.73839973
45	MKNK1	0.73470080
46	NME2	0.72300085
47	ABL2	0.69950376
48	PKN1	0.69590389
49	MAP3K5	0.64900607
50	NEK2	0.63883263
51	FGR	0.63839988
52	PRKCE	0.62317260
53	GRK7	0.62197377
54	PIM2	0.60980043
55	STK38	0.60130341
56	CAMK2A	0.58449458
57	PTK2B	0.57505779
58	PINK1	0.52416488
59	SCYL2	0.51591591
60	STK10	0.51312169
61	LATS1	0.51248541
62	TAOK3	0.50609119
63	TSSK6	0.50268755
64	CAMK2G	0.47706917
65	MAP3K11	0.47628377
66	BMX	0.47113419
67	IRAK3	0.45637395
68	TYK2	0.45619313
69	CSNK2A1	0.44964733
70	MKNK2	0.43884303
71	CAMK2D	0.43535482
72	EGFR	0.43275725
73	PIK3CG	0.41791240
74	VRK1	0.41601270
75	ADRBK1	0.41006895
76	CCNB1	0.40786708
77	ATM	0.40357692
78	LYN	0.39397258
79	AKT2	0.37967896
80	DDR2	0.37843692
81	MST4	0.36599861
82	CAMKK2	0.36454966
83	CDK8	0.36233278
84	PRKCG	0.36233151
85	STK3	0.34617881
86	NME1	0.33357044
87	IKBKB	0.33233252
88	PAK4	0.32348610
89	PRKACB	0.32347021
90	MOS	0.30795685
91	VRK2	0.30536006
92	ERBB2	0.30253491
93	EPHA3	0.29766528
94	AURKA	0.29130811
95	CSNK1D	0.28897568
96	CSNK1A1	0.28793683
97	PRKACA	0.28142326
98	TESK1	0.26161178
99	ERBB4	0.25941171
100	PRKCI	0.25726722

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Proteasome_Homo sapiens_hsa03050	3.59792771
2	Protein export_Homo sapiens_hsa03060	3.51998002
3	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.64667499
4	Fatty acid elongation_Homo sapiens_hsa00062	2.59776377
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.31313288
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.13965994
7	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.04726183
8	Asthma_Homo sapiens_hsa05310	2.02340815
9	Fatty acid biosynthesis_Homo sapiens_hsa00061	1.99752853
10	Collecting duct acid secretion_Homo sapiens_hsa04966	1.91258606
11	Glutathione metabolism_Homo sapiens_hsa00480	1.91012002
12	Parkinsons disease_Homo sapiens_hsa05012	1.85178025
13	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.81378542
14	Rheumatoid arthritis_Homo sapiens_hsa05323	1.80983028
15	Homologous recombination_Homo sapiens_hsa03440	1.70209511
16	Allograft rejection_Homo sapiens_hsa05330	1.69442250
17	Nitrogen metabolism_Homo sapiens_hsa00910	1.65710794
18	Sulfur metabolism_Homo sapiens_hsa00920	1.62926707
19	Propanoate metabolism_Homo sapiens_hsa00640	1.60356564
20	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.54773062
21	Autoimmune thyroid disease_Homo sapiens_hsa05320	1.54707962
22	Circadian rhythm_Homo sapiens_hsa04710	1.54645181
23	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.52228748
24	Mismatch repair_Homo sapiens_hsa03430	1.48140452
25	Peroxisome_Homo sapiens_hsa04146	1.43668499
26	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.42561194
27	Fructose and mannose metabolism_Homo sapiens_hsa00051	1.41736237
28	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	1.41646504
29	Graft-versus-host disease_Homo sapiens_hsa05332	1.39057122
30	Lysosome_Homo sapiens_hsa04142	1.34216698
31	Fatty acid metabolism_Homo sapiens_hsa01212	1.34052257
32	Legionellosis_Homo sapiens_hsa05134	1.33675369
33	Basal transcription factors_Homo sapiens_hsa03022	1.28688461
34	Caffeine metabolism_Homo sapiens_hsa00232	1.28552032
35	Folate biosynthesis_Homo sapiens_hsa00790	1.26606005
36	Sphingolipid metabolism_Homo sapiens_hsa00600	1.21684135
37	Huntingtons disease_Homo sapiens_hsa05016	1.21677234
38	Base excision repair_Homo sapiens_hsa03410	1.20967645
39	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.19584286
40	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.14511107
41	Glycosaminoglycan degradation_Homo sapiens_hsa00531	1.14416638
42	Phototransduction_Homo sapiens_hsa04744	1.13179379
43	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.10142776
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.09617246
45	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.09353720
46	Type I diabetes mellitus_Homo sapiens_hsa04940	1.08906351
47	Alzheimers disease_Homo sapiens_hsa05010	1.05762783
48	Antigen processing and presentation_Homo sapiens_hsa04612	1.01897511
49	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	1.00760019
50	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.99140082
51	Galactose metabolism_Homo sapiens_hsa00052	0.98981979
52	Fanconi anemia pathway_Homo sapiens_hsa03460	0.98736850
53	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.98361443
54	Pyrimidine metabolism_Homo sapiens_hsa00240	0.98293586
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.97548738
56	Non-homologous end-joining_Homo sapiens_hsa03450	0.95616774
57	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.95084996
58	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.94047037
59	Fatty acid degradation_Homo sapiens_hsa00071	0.93561141
60	Phagosome_Homo sapiens_hsa04145	0.93428949
61	Chemical carcinogenesis_Homo sapiens_hsa05204	0.93222533
62	Other glycan degradation_Homo sapiens_hsa00511	0.89262071
63	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.88931333
64	DNA replication_Homo sapiens_hsa03030	0.87246477
65	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.85852839
66	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.84714618
67	One carbon pool by folate_Homo sapiens_hsa00670	0.84164996
68	RNA transport_Homo sapiens_hsa03013	0.82104550
69	Regulation of autophagy_Homo sapiens_hsa04140	0.78185918
70	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.76200994
71	RNA polymerase_Homo sapiens_hsa03020	0.74219626
72	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.73571889
73	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.72778848
74	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.72538267
75	RNA degradation_Homo sapiens_hsa03018	0.70764878
76	Vibrio cholerae infection_Homo sapiens_hsa05110	0.69896458
77	Butanoate metabolism_Homo sapiens_hsa00650	0.69648850
78	Metabolic pathways_Homo sapiens_hsa01100	0.68401207
79	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.66327994
80	Olfactory transduction_Homo sapiens_hsa04740	0.65904744
81	Mineral absorption_Homo sapiens_hsa04978	0.65646882
82	Selenocompound metabolism_Homo sapiens_hsa00450	0.64969221
83	Tryptophan metabolism_Homo sapiens_hsa00380	0.59695110
84	Herpes simplex infection_Homo sapiens_hsa05168	0.56336584
85	Tyrosine metabolism_Homo sapiens_hsa00350	0.55689202
86	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.54495001
87	ABC transporters_Homo sapiens_hsa02010	0.52934785
88	Complement and coagulation cascades_Homo sapiens_hsa04610	0.52331844
89	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52256203
90	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.51698295
91	Spliceosome_Homo sapiens_hsa03040	0.51257164
92	Malaria_Homo sapiens_hsa05144	0.49506862
93	beta-Alanine metabolism_Homo sapiens_hsa00410	0.49266587
94	p53 signaling pathway_Homo sapiens_hsa04115	0.49075875
95	Pyruvate metabolism_Homo sapiens_hsa00620	0.48317197
96	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.44949643
97	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42116590
98	Viral myocarditis_Homo sapiens_hsa05416	0.41773289
99	Nucleotide excision repair_Homo sapiens_hsa03420	0.40845860
100	Tuberculosis_Homo sapiens_hsa05152	0.37794592

CTSLP8

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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