CTSO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by the gene is a cysteine proteinase and a member of the papain superfamily. This proteolytic enzyme is involved in cellular protein degradation and turnover. The recombinant form of this enzyme was shown to degrade synthetic peptides typically used as substrates for cysteine proteinases and its proteolytic activity was abolished by an inhibitor of cyteine proteinase. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.45704379
2L-phenylalanine catabolic process (GO:0006559)5.45704379
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.05418753
4L-phenylalanine metabolic process (GO:0006558)5.05418753
5triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.78032603
6alpha-linolenic acid metabolic process (GO:0036109)4.77289650
7aromatic amino acid family catabolic process (GO:0009074)4.60688552
8low-density lipoprotein particle remodeling (GO:0034374)4.42087562
9negative regulation of cell killing (GO:0031342)4.37645230
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.37645230
11antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.16601965
12bile acid biosynthetic process (GO:0006699)4.16397715
13reverse cholesterol transport (GO:0043691)4.12646155
14fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.09256281
15regulation of cholesterol esterification (GO:0010872)4.01894978
16tryptophan catabolic process (GO:0006569)3.88178122
17indole-containing compound catabolic process (GO:0042436)3.88178122
18indolalkylamine catabolic process (GO:0046218)3.88178122
19high-density lipoprotein particle remodeling (GO:0034375)3.82932169
20tryptophan metabolic process (GO:0006568)3.74008278
21protein-lipid complex remodeling (GO:0034368)3.73926572
22macromolecular complex remodeling (GO:0034367)3.73926572
23plasma lipoprotein particle remodeling (GO:0034369)3.73926572
24sulfur amino acid catabolic process (GO:0000098)3.69587556
25phospholipid efflux (GO:0033700)3.66969366
26complement activation, alternative pathway (GO:0006957)3.61073650
27antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.60540584
28antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.60540584
29glyoxylate metabolic process (GO:0046487)3.57421839
30complement activation, classical pathway (GO:0006958)3.55715627
31bile acid metabolic process (GO:0008206)3.53152316
32protein carboxylation (GO:0018214)3.52854188
33peptidyl-glutamic acid carboxylation (GO:0017187)3.52854188
34kynurenine metabolic process (GO:0070189)3.49960524
35antigen processing and presentation of endogenous antigen (GO:0019883)3.46326138
36regulation of triglyceride catabolic process (GO:0010896)3.41475647
37regulation of protein activation cascade (GO:2000257)3.41259480
38complement activation (GO:0006956)3.40823473
39plasma lipoprotein particle assembly (GO:0034377)3.40742227
40cysteine metabolic process (GO:0006534)3.36281118
41very long-chain fatty acid metabolic process (GO:0000038)3.35370417
42regulation of dendritic cell antigen processing and presentation (GO:0002604)3.34235205
43positive regulation of gamma-delta T cell activation (GO:0046645)3.29912598
44regulation of cholesterol biosynthetic process (GO:0045540)3.29268110
45valine metabolic process (GO:0006573)3.29163980
46plasma lipoprotein particle organization (GO:0071827)3.25761885
47detection of other organism (GO:0098543)3.25422163
48regulation of cholesterol metabolic process (GO:0090181)3.24372042
49regulation of complement activation (GO:0030449)3.23977493
50tyrosine metabolic process (GO:0006570)3.21211198
51protein activation cascade (GO:0072376)3.20650561
52detection of bacterium (GO:0016045)3.17393615
53opsonization (GO:0008228)3.16999756
54aromatic amino acid family metabolic process (GO:0009072)3.16314762
55cellular modified amino acid catabolic process (GO:0042219)3.15213307
56imidazole-containing compound metabolic process (GO:0052803)3.15104876
57negative regulation of fibrinolysis (GO:0051918)3.13225797
58regulation of fibrinolysis (GO:0051917)3.11069667
59protein-lipid complex assembly (GO:0065005)3.10820174
60plasma lipoprotein particle clearance (GO:0034381)3.10042581
61protein-lipid complex subunit organization (GO:0071825)3.09354263
62very-low-density lipoprotein particle assembly (GO:0034379)3.09045182
63ethanol oxidation (GO:0006069)3.07623062
64fatty acid beta-oxidation (GO:0006635)3.07145466
65negative regulation of cholesterol transport (GO:0032375)3.04111264
66negative regulation of sterol transport (GO:0032372)3.04111264
67alpha-amino acid catabolic process (GO:1901606)3.03712281
68cholesterol efflux (GO:0033344)3.03678809
69lipid oxidation (GO:0034440)3.02228604
70immunoglobulin mediated immune response (GO:0016064)3.01579541
71cholesterol catabolic process (GO:0006707)3.00710294
72sterol catabolic process (GO:0016127)3.00710294
73epoxygenase P450 pathway (GO:0019373)2.98817600
74short-chain fatty acid metabolic process (GO:0046459)2.98191825
75urea metabolic process (GO:0019627)2.95494845
76urea cycle (GO:0000050)2.95494845
77acylglycerol homeostasis (GO:0055090)2.93303690
78triglyceride homeostasis (GO:0070328)2.93303690
79fatty acid oxidation (GO:0019395)2.92966444
80amino-acid betaine metabolic process (GO:0006577)2.92694436
81cellular biogenic amine catabolic process (GO:0042402)2.92199050
82amine catabolic process (GO:0009310)2.92199050
83cellular amino acid catabolic process (GO:0009063)2.90622862
84fatty acid catabolic process (GO:0009062)2.90488315
85homocysteine metabolic process (GO:0050667)2.89516947
86cellular glucuronidation (GO:0052695)2.86601520
87monocarboxylic acid catabolic process (GO:0072329)2.85347253
88peptide catabolic process (GO:0043171)2.85280120
89exogenous drug catabolic process (GO:0042738)2.83870760
90indolalkylamine metabolic process (GO:0006586)2.81026023
91interferon-gamma-mediated signaling pathway (GO:0060333)2.80294539
92cellular ketone body metabolic process (GO:0046950)2.79717451
93cellular response to type I interferon (GO:0071357)2.79296453
94type I interferon signaling pathway (GO:0060337)2.79296453
95nitrogen cycle metabolic process (GO:0071941)2.79267138
96detection of external biotic stimulus (GO:0098581)2.78859324
97positive regulation of cellular amide metabolic process (GO:0034250)2.78040257
98response to type I interferon (GO:0034340)2.77710432
99positive regulation of triglyceride metabolic process (GO:0090208)2.77616637
100positive regulation of antigen processing and presentation (GO:0002579)2.77494516
101organic acid catabolic process (GO:0016054)2.74839877
102carboxylic acid catabolic process (GO:0046395)2.74839877
103bile acid and bile salt transport (GO:0015721)2.73880409
104phospholipid homeostasis (GO:0055091)2.72319233
105positive regulation of triglyceride biosynthetic process (GO:0010867)2.71342229
106regulation of antigen processing and presentation (GO:0002577)2.71316543
107germinal center formation (GO:0002467)2.71240787
108cellular response to cholesterol (GO:0071397)2.70358490
109lipoprotein metabolic process (GO:0042157)2.69938132
110regulation of triglyceride metabolic process (GO:0090207)2.68927975
111positive regulation of lipoprotein lipase activity (GO:0051006)2.67962764
112positive regulation of triglyceride lipase activity (GO:0061365)2.67962764
113regulation of cholesterol homeostasis (GO:2000188)2.67708165
114drug transmembrane transport (GO:0006855)2.67153182
115glutamate metabolic process (GO:0006536)2.66777037
116regulation of gamma-delta T cell activation (GO:0046643)2.65434889
117positive regulation of steroid metabolic process (GO:0045940)2.65163297
118serine family amino acid catabolic process (GO:0009071)2.64625080
119signal peptide processing (GO:0006465)2.63762065
120coenzyme catabolic process (GO:0009109)2.63400771
121regulation of gamma-delta T cell differentiation (GO:0045586)2.60075907
122positive regulation of type 2 immune response (GO:0002830)2.59676800
123drug catabolic process (GO:0042737)2.59307733
124macrophage activation involved in immune response (GO:0002281)2.57721180
125negative regulation of lymphocyte mediated immunity (GO:0002707)2.55804683
126regulation of T cell mediated cytotoxicity (GO:0001914)2.55461883
127regulation of germinal center formation (GO:0002634)2.54233325
128modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.51251182
129positive regulation by organism of defense response of other organism involved in symbiotic interact2.51251182
130modulation by symbiont of host immune response (GO:0052553)2.51251182
131positive regulation by symbiont of host defense response (GO:0052509)2.51251182
132modulation by symbiont of host defense response (GO:0052031)2.51251182
133modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.51251182
134negative regulation of innate immune response (GO:0045824)2.49041370
135regulation of B cell receptor signaling pathway (GO:0050855)2.48829184
136response to peptidoglycan (GO:0032494)2.48606370
137negative regulation of humoral immune response (GO:0002921)2.47573742
138positive regulation of sterol transport (GO:0032373)2.45855810
139positive regulation of cholesterol transport (GO:0032376)2.45855810
140negative regulation of leukocyte mediated immunity (GO:0002704)2.44222901
141omega-hydroxylase P450 pathway (GO:0097267)2.43150064
142detection of biotic stimulus (GO:0009595)2.41911262
143positive regulation of T cell mediated cytotoxicity (GO:0001916)2.41237363
144neutrophil activation involved in immune response (GO:0002283)2.40071894
145T-helper 1 type immune response (GO:0042088)2.40062759
146detection of molecule of bacterial origin (GO:0032490)2.39716190
147positive thymic T cell selection (GO:0045059)2.39577995
148ethanol metabolic process (GO:0006067)2.39265994
149hormone catabolic process (GO:0042447)2.36708900
150adhesion of symbiont to host cell (GO:0044650)2.36020020
151virion attachment to host cell (GO:0019062)2.36020020
152regulation of macrophage chemotaxis (GO:0010758)2.35581505
153positive regulation of cholesterol efflux (GO:0010875)2.34864271
154regulation of type 2 immune response (GO:0002828)2.33947732
155negative regulation of interleukin-12 production (GO:0032695)2.33152142
156regulation of T-helper 1 cell differentiation (GO:0045625)2.32641562
157negative regulation of erythrocyte differentiation (GO:0045647)2.32403948
158negative regulation of complement activation (GO:0045916)2.30651704
159regulation of T-helper 2 cell differentiation (GO:0045628)2.29389701
160B cell mediated immunity (GO:0019724)2.27949195
161urate metabolic process (GO:0046415)2.27405123
162regulation of tolerance induction (GO:0002643)2.27241007
163regulation of interferon-beta biosynthetic process (GO:0045357)2.26907338
164positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.25778242
165negative regulation of protein activation cascade (GO:2000258)2.25326722
166keratan sulfate catabolic process (GO:0042340)2.24639055
167response to muramyl dipeptide (GO:0032495)2.24135305
168positive regulation of macrophage cytokine production (GO:0060907)2.22494235
169regulation of humoral immune response (GO:0002920)2.21547852
170negative thymic T cell selection (GO:0045060)2.20379939
171regulation of macrophage cytokine production (GO:0010935)2.19776479
172positive regulation of B cell differentiation (GO:0045579)2.19358116
173regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.18579256
174amino sugar catabolic process (GO:0046348)2.16753903
175fat-soluble vitamin biosynthetic process (GO:0042362)2.16127201
176production of molecular mediator involved in inflammatory response (GO:0002532)2.15205728
177negative regulation of type 2 immune response (GO:0002829)2.14296154
178cellular response to thyroid hormone stimulus (GO:0097067)2.14060578
179microglial cell activation (GO:0001774)2.14045795
180cellular response to interferon-gamma (GO:0071346)2.13314354
181antigen processing and presentation via MHC class Ib (GO:0002475)2.13236623
182regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.13029341
183regulation of leukocyte mediated cytotoxicity (GO:0001910)2.11687796
184positive regulation of tolerance induction (GO:0002645)2.09850599
185regulation of cellular extravasation (GO:0002691)2.09070086
186negative T cell selection (GO:0043383)2.09025262

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.38418912
2RXR_22158963_ChIP-Seq_LIVER_Mouse5.30778574
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.71057271
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.63616088
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.57471070
6LXR_22158963_ChIP-Seq_LIVER_Mouse4.32493884
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.47109512
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.40531772
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.39755758
10CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.16635835
11GATA1_22025678_ChIP-Seq_K562_Human2.87729979
12CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.61934781
13* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.51987150
14IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.41092778
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.29480646
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.26576908
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.25324503
18SMAD_19615063_ChIP-ChIP_OVARY_Human2.17006450
19IRF8_27001747_Chip-Seq_BMDM_Mouse1.96172060
20SCL_19346495_ChIP-Seq_HPC-7_Human1.94686332
21STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80504196
22RUNX_20019798_ChIP-Seq_JUKART_Human1.75411719
23STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.74629260
24SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.69445873
25LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.66400865
26THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.66352320
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.64031518
28NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.59291165
29MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.56412740
30NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.55170989
31TRIM28_21343339_ChIP-Seq_HEK293_Human1.48032732
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42300643
33RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.42062982
34Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.41165632
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.40588143
36CLOCK_20551151_ChIP-Seq_293T_Human1.36135305
37GATA2_21666600_ChIP-Seq_HMVEC_Human1.32789915
38TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.31124683
39NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.30267566
40TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27804490
41GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.25188128
42MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.22908061
43FOXA2_19822575_ChIP-Seq_HepG2_Human1.17746389
44RUNX1_22412390_ChIP-Seq_EML_Mouse1.13766628
45SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.13114086
46ESR1_21235772_ChIP-Seq_MCF-7_Human1.12185852
47LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11663705
48BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10741112
49STAT4_19710469_ChIP-ChIP_TH1__Mouse1.10725033
50PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.10718056
51STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10480524
52ESR1_20079471_ChIP-ChIP_T-47D_Human1.10414782
53SPI1_23547873_ChIP-Seq_NB4_Human1.07290643
54TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07197491
55HTT_18923047_ChIP-ChIP_STHdh_Human1.06959276
56GATA1_19941826_ChIP-Seq_K562_Human1.05957233
57RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04205430
58FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.04170184
59E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99339066
60HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.97421566
61* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.96158713
62* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.96158713
63CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.92343240
64P63_26484246_Chip-Seq_KERATINOCYTES_Human0.91414428
65CJUN_26792858_Chip-Seq_BT549_Human0.91409910
66PPAR_26484153_Chip-Seq_NCI-H1993_Human0.89530065
67GATA3_27048872_Chip-Seq_THYMUS_Human0.89449981
68GATA2_19941826_ChIP-Seq_K562_Human0.87982783
69GATA1_19941827_ChIP-Seq_MEL_Mouse0.87793620
70AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.86489439
71KDM2B_26808549_Chip-Seq_SUP-B15_Human0.86194164
72* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85845987
73VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.85235526
74CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84226546
75SOX2_20726797_ChIP-Seq_SW620_Human0.84001603
76MYB_21317192_ChIP-Seq_ERMYB_Mouse0.83419112
77GATA3_26560356_Chip-Seq_TH2_Human0.83326845
78EP300_21415370_ChIP-Seq_HL-1_Mouse0.82295222
79SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.82224047
80PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.81779744
81* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.80708267
82SALL4_18804426_ChIP-ChIP_XEN_Mouse0.79753315
83MYB_26560356_Chip-Seq_TH2_Human0.79659751
84* TP63_23658742_ChIP-Seq_EP156T_Human0.79219102
85FOXO3_23340844_ChIP-Seq_DLD1_Human0.79092516
86TCF7_22412390_ChIP-Seq_EML_Mouse0.78905543
87PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.78659507
88VDR_24787735_ChIP-Seq_THP-1_Human0.78550996
89AR_20517297_ChIP-Seq_VCAP_Human0.77508778
90IKZF1_21737484_ChIP-ChIP_HCT116_Human0.76286444
91TBX20_22080862_ChIP-Seq_HEART_Mouse0.76024157
92TBX20_22328084_ChIP-Seq_HEART_Mouse0.76024157
93MYB_26560356_Chip-Seq_TH1_Human0.76014258
94ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.75526529
95MAF_26560356_Chip-Seq_TH1_Human0.75198903
96* HNF4A_19822575_ChIP-Seq_HepG2_Human0.74792643
97CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74335834
98ELK3_25401928_ChIP-Seq_HUVEC_Human0.73906164
99PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.73787638
100CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.73554453
101ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.73356643
102PU_27001747_Chip-Seq_BMDM_Mouse0.73187818
103SPI1_23127762_ChIP-Seq_K562_Human0.72650774
104CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.72336485
105BRD4_27068464_Chip-Seq_AML-cells_Mouse0.71788630
106FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.71622292
107FOXA1_25552417_ChIP-Seq_VCAP_Human0.69709562
108PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.68345674
109VDR_24763502_ChIP-Seq_THP-1_Human0.68144800
110GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.68059608
111EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.67674274
112GATA2_22383799_ChIP-Seq_G1ME_Mouse0.67568795
113CDX2_19796622_ChIP-Seq_MESCs_Mouse0.67311382
114PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.67264016
115GATA1_22383799_ChIP-Seq_G1ME_Mouse0.66793586
116FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66627249
117PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.65851820
118CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65378643
119EGR1_19032775_ChIP-ChIP_M12_Human0.65130100
120SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.63967909
121CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.63852537
122RXR_22108803_ChIP-Seq_LS180_Human0.63509048
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.63253010
124SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.63048681
125SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.62636236
126ESR2_21235772_ChIP-Seq_MCF-7_Human0.61640908
127ELF1_17652178_ChIP-ChIP_JURKAT_Human0.60189678
128PU.1_20513432_ChIP-Seq_Bcells_Mouse0.59504822

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.42757233
2MP0005360_urolithiasis4.70289325
3MP0005365_abnormal_bile_salt4.08103552
4MP0005085_abnormal_gallbladder_physiolo3.92519681
5MP0008875_abnormal_xenobiotic_pharmacok3.39194321
6MP0009840_abnormal_foam_cell3.10778421
7MP0010329_abnormal_lipoprotein_level2.79651918
8MP0003252_abnormal_bile_duct2.66614861
9MP0003303_peritoneal_inflammation2.65196800
10MP0003195_calcinosis2.57482614
11MP0003806_abnormal_nucleotide_metabolis2.56031445
12MP0003191_abnormal_cellular_cholesterol2.53552223
13MP0002254_reproductive_system_inflammat2.41537459
14MP0001835_abnormal_antigen_presentation2.31065982
15MP0005332_abnormal_amino_acid2.24892575
16MP0003690_abnormal_glial_cell2.15051216
17MP0009278_abnormal_bone_marrow2.04870602
18MP0005671_abnormal_response_to1.96190303
19MP0005058_abnormal_lysosome_morphology1.92715798
20MP0002138_abnormal_hepatobiliary_system1.87283264
21MP0001666_abnormal_nutrient_absorption1.85825632
22MP0002118_abnormal_lipid_homeostasis1.84367350
23MP0000685_abnormal_immune_system1.82302115
24MP0003868_abnormal_feces_composition1.81909295
25MP0000609_abnormal_liver_physiology1.70668592
26MP0001853_heart_inflammation1.69524796
27MP0001958_emphysema1.67539005
28MP0005083_abnormal_biliary_tract1.60537375
29MP0003724_increased_susceptibility_to1.59184044
30MP0000465_gastrointestinal_hemorrhage1.59077893
31MP0002405_respiratory_system_inflammati1.59072819
32MP0001790_abnormal_immune_system1.57734089
33MP0005387_immune_system_phenotype1.57734089
34MP0009785_altered_susceptibility_to1.57035069
35MP0008438_abnormal_cutaneous_collagen1.56943654
36MP0000604_amyloidosis1.55408632
37MP0005584_abnormal_enzyme/coenzyme_acti1.53473430
38MP0001545_abnormal_hematopoietic_system1.52313442
39MP0005397_hematopoietic_system_phenotyp1.52313442
40MP0003183_abnormal_peptide_metabolism1.51177684
41MP0002998_abnormal_bone_remodeling1.49263461
42MP0009764_decreased_sensitivity_to1.49028876
43MP0001800_abnormal_humoral_immune1.44334568
44MP0005275_abnormal_skin_tensile1.43721565
45MP0009643_abnormal_urine_homeostasis1.41920827
46MP0002419_abnormal_innate_immunity1.41177071
47MP0001764_abnormal_homeostasis1.40037135
48MP0005464_abnormal_platelet_physiology1.39178938
49MP0009333_abnormal_splenocyte_physiolog1.38718697
50MP0005025_abnormal_response_to1.38698250
51MP0008469_abnormal_protein_level1.36265141
52MP0004019_abnormal_vitamin_homeostasis1.34554645
53MP0005000_abnormal_immune_tolerance1.33130914
54MP0005319_abnormal_enzyme/_coenzyme1.32662428
55MP0005164_abnormal_response_to1.30465767
56MP0003186_abnormal_redox_activity1.29906180
57MP0003300_gastrointestinal_ulcer1.27136443
58MP0003172_abnormal_lysosome_physiology1.26030860
59MP0005166_decreased_susceptibility_to1.25933860
60MP0000681_abnormal_thyroid_gland1.25013275
61MP0006082_CNS_inflammation1.23435744
62MP0002723_abnormal_immune_serum1.21249748
63MP0006054_spinal_hemorrhage1.20863054
64MP0004883_abnormal_blood_vessel1.20634908
65MP0002452_abnormal_antigen_presenting1.17230313
66MP0003329_amyloid_beta_deposits1.16809131
67MP0002166_altered_tumor_susceptibility1.16245112
68MP0001851_eye_inflammation1.15661252
69MP0003075_altered_response_to1.14683962
70MP0000343_altered_response_to1.14155324
71MP0002876_abnormal_thyroid_physiology1.13062901
72MP0003828_pulmonary_edema1.12229860
73MP0000920_abnormal_myelination1.11763729
74MP0000249_abnormal_blood_vessel1.10991100
75MP0005390_skeleton_phenotype1.09038127
76MP0003436_decreased_susceptibility_to1.08231554
77MP0001542_abnormal_bone_strength1.08024039
78MP0009697_abnormal_copulation1.07105947
79MP0001845_abnormal_inflammatory_respons1.06139026
80MP0009763_increased_sensitivity_to1.04418379
81MP0002148_abnormal_hypersensitivity_rea1.03072912
82MP0002420_abnormal_adaptive_immunity1.02958998
83MP0002933_joint_inflammation1.00828533
84MP0001819_abnormal_immune_cell1.00593532
85MP0005503_abnormal_tendon_morphology0.97373459
86MP0008004_abnormal_stomach_pH0.97182834
87MP0003763_abnormal_thymus_physiology0.96793703
88MP0003866_abnormal_defecation0.94809147
89MP0002078_abnormal_glucose_homeostasis0.93814808
90MP0000858_altered_metastatic_potential0.93579354
91MP0005647_abnormal_sex_gland0.93020097
92MP0005167_abnormal_blood-brain_barrier0.91681083
93MP0003011_delayed_dark_adaptation0.91331324
94MP0009642_abnormal_blood_homeostasis0.90574148
95MP0010368_abnormal_lymphatic_system0.90014198
96MP0002971_abnormal_brown_adipose0.89923097
97MP0001873_stomach_inflammation0.89459295
98MP0005379_endocrine/exocrine_gland_phen0.89404024
99MP0005636_abnormal_mineral_homeostasis0.89140299
100MP0000598_abnormal_liver_morphology0.87801337
101MP0002909_abnormal_adrenal_gland0.87782348
102MP0002398_abnormal_bone_marrow0.87326911
103MP0004130_abnormal_muscle_cell0.86709307
104MP0005310_abnormal_salivary_gland0.85580583
105MP0005023_abnormal_wound_healing0.85367583
106MP0003448_altered_tumor_morphology0.84843224
107MP0002006_tumorigenesis0.84524928
108MP0003656_abnormal_erythrocyte_physiolo0.83478204
109MP0000639_abnormal_adrenal_gland0.82569544
110MP0003638_abnormal_response/metabolism_0.82402074
111MP0005670_abnormal_white_adipose0.81839875
112MP0002009_preneoplasia0.81663102
113MP0009384_cardiac_valve_regurgitation0.81450707
114MP0003091_abnormal_cell_migration0.81243047
115MP0000689_abnormal_spleen_morphology0.80443969
116MP0005645_abnormal_hypothalamus_physiol0.79675205
117MP0003795_abnormal_bone_structure0.79040770
118MP0002928_abnormal_bile_duct0.78444387
119MP0004510_myositis0.77186802
120MP0002090_abnormal_vision0.77088617
121MP0005165_increased_susceptibility_to0.76848599
122MP0005646_abnormal_pituitary_gland0.76737106
123MP0005334_abnormal_fat_pad0.76349101
124MP0004043_abnormal_pH_regulation0.76187972
125MP0000716_abnormal_immune_system0.76052060
126MP0005084_abnormal_gallbladder_morpholo0.75607571
127MP0005535_abnormal_body_temperature0.75245079
128MP0003045_fibrosis0.74722145
129MP0004947_skin_inflammation0.74454487
130MP0003279_aneurysm0.74126207
131MP0000013_abnormal_adipose_tissue0.73899103
132MP0002136_abnormal_kidney_physiology0.73676124
133MP0005220_abnormal_exocrine_pancreas0.72190268
134MP0009765_abnormal_xenobiotic_induced0.70868581
135MP0002693_abnormal_pancreas_physiology0.70535188
136MP0010155_abnormal_intestine_physiology0.69550324
137MP0004147_increased_porphyrin_level0.68369655
138MP0001533_abnormal_skeleton_physiology0.68261069

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.84471685
2Intrahepatic cholestasis (HP:0001406)4.97362984
3Xanthomatosis (HP:0000991)4.73026345
4Prolonged partial thromboplastin time (HP:0003645)4.68890482
5Deep venous thrombosis (HP:0002625)4.40621453
6Hyperlipoproteinemia (HP:0010980)4.30802737
7Hypoglycemic coma (HP:0001325)4.01551405
8Complement deficiency (HP:0004431)3.89600588
9Myositis (HP:0100614)3.86753609
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.81852836
11Joint hemorrhage (HP:0005261)3.77695387
12Abnormality of glycolipid metabolism (HP:0010969)3.71250202
13Abnormality of liposaccharide metabolism (HP:0010968)3.71250202
14Abnormality of glycosphingolipid metabolism (HP:0004343)3.71250202
15Hypobetalipoproteinemia (HP:0003563)3.65914186
16Orchitis (HP:0100796)3.57506371
17Ketosis (HP:0001946)3.52116239
18Optic neuritis (HP:0100653)3.33071594
19Retrobulbar optic neuritis (HP:0100654)3.33071594
20Abnormality of the common coagulation pathway (HP:0010990)3.29881601
21Ketoacidosis (HP:0001993)3.29524488
22Systemic lupus erythematosus (HP:0002725)3.28976544
23Hyperammonemia (HP:0001987)3.24511410
24Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.16308263
25Hypoglycemic seizures (HP:0002173)3.16011691
26Abnormality of the intrinsic pathway (HP:0010989)3.13420557
27Hyperglycinuria (HP:0003108)3.08083777
28Abnormality of serine family amino acid metabolism (HP:0010894)2.98982381
29Abnormality of glycine metabolism (HP:0010895)2.98982381
30Abnormality of methionine metabolism (HP:0010901)2.97556529
31Hypolipoproteinemia (HP:0010981)2.97274544
32Abnormality of fatty-acid metabolism (HP:0004359)2.97035814
33Vacuolated lymphocytes (HP:0001922)2.94030503
34Fat malabsorption (HP:0002630)2.92557437
35Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.88932756
36Pulmonary infiltrates (HP:0002113)2.88020773
37Abnormality of aspartate family amino acid metabolism (HP:0010899)2.87845276
38Epidermoid cyst (HP:0200040)2.86877989
39Generalized aminoaciduria (HP:0002909)2.84232717
40Recurrent abscess formation (HP:0002722)2.79194434
41Hypoalphalipoproteinemia (HP:0003233)2.79104014
42Hyperglycinemia (HP:0002154)2.76112764
43Dysostosis multiplex (HP:0000943)2.72304670
44Amyloidosis (HP:0011034)2.71534141
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.67449884
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.66965746
47Hyperinsulinemic hypoglycemia (HP:0000825)2.66900450
48Hypercholesterolemia (HP:0003124)2.63929909
49Abnormality of macrophages (HP:0004311)2.63825028
50Mitral stenosis (HP:0001718)2.61696645
51Abnormality of complement system (HP:0005339)2.60699068
52Recurrent gram-negative bacterial infections (HP:0005420)2.58881593
53Gastrointestinal infarctions (HP:0005244)2.58867932
54Spondylolisthesis (HP:0003302)2.58301820
55Gingival bleeding (HP:0000225)2.57257423
56Hyperbilirubinemia (HP:0002904)2.55575739
57Late onset (HP:0003584)2.55388325
58Conjugated hyperbilirubinemia (HP:0002908)2.55385695
59Gastrointestinal stroma tumor (HP:0100723)2.54572046
60Increased neuronal autofluorescent lipopigment (HP:0002074)2.54167471
61Hypoplasia of the thymus (HP:0000778)2.51756656
62Pustule (HP:0200039)2.51314728
63Agammaglobulinemia (HP:0004432)2.47032504
64Glomerulonephritis (HP:0000099)2.46334556
65Hemoptysis (HP:0002105)2.45267251
66Chronic otitis media (HP:0000389)2.43538789
67Meningitis (HP:0001287)2.43470789
68Keratoconjunctivitis sicca (HP:0001097)2.42250867
69Delayed CNS myelination (HP:0002188)2.42030913
70Symptomatic seizures (HP:0011145)2.41457840
71Increased cerebral lipofuscin (HP:0011813)2.38659531
72Recurrent bronchitis (HP:0002837)2.38206839
73Nephritis (HP:0000123)2.34800382
74Gingivitis (HP:0000230)2.33692778
75Purpura (HP:0000979)2.33062849
76Myocardial infarction (HP:0001658)2.32597492
77Steatorrhea (HP:0002570)2.32394667
78Dicarboxylic aciduria (HP:0003215)2.31805180
79Abnormality of dicarboxylic acid metabolism (HP:0010995)2.31805180
80Asymmetric septal hypertrophy (HP:0001670)2.30227144
81Interstitial pulmonary disease (HP:0006530)2.29813810
82Neurofibrillary tangles (HP:0002185)2.29608174
83Keratoconjunctivitis (HP:0001096)2.28277592
84Arterial thrombosis (HP:0004420)2.28252252
85Progressive neurologic deterioration (HP:0002344)2.27683698
86Recurrent skin infections (HP:0001581)2.26041959
87Abnormal delayed hypersensitivity skin test (HP:0002963)2.25302604
88Mucopolysacchariduria (HP:0008155)2.24695317
89Urinary glycosaminoglycan excretion (HP:0003541)2.24695317
90Mediastinal lymphadenopathy (HP:0100721)2.21887724
91Sensorimotor neuropathy (HP:0007141)2.19351954
92Inflammation of the large intestine (HP:0002037)2.17712130
93Aortic dissection (HP:0002647)2.17062395
94Malnutrition (HP:0004395)2.13078726
95Premature loss of primary teeth (HP:0006323)2.12500211
96Recurrent sinusitis (HP:0011108)2.11178649
97Recurrent fungal infections (HP:0002841)2.11105190
98Elevated hepatic transaminases (HP:0002910)2.10588658
99Urticaria (HP:0001025)2.09794435
100Encephalitis (HP:0002383)2.07647727
101Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06214440
102Abnormality of polysaccharide metabolism (HP:0011012)2.06214440
103Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06214440
104Gangrene (HP:0100758)2.04231280
105Joint swelling (HP:0001386)2.04201718
106Elevated erythrocyte sedimentation rate (HP:0003565)2.04147568
107Metaphyseal dysplasia (HP:0100255)2.02609722
108Gastrointestinal inflammation (HP:0004386)2.01362100
109Pancreatitis (HP:0001733)2.00168514
110Stomatitis (HP:0010280)1.99764373
111Increased IgE level (HP:0003212)1.97833878
112Peritonitis (HP:0002586)1.97462724
113Abnormality of T cell number (HP:0011839)1.96911885
114Hypergammaglobulinemia (HP:0010702)1.96657393
115T lymphocytopenia (HP:0005403)1.94746365
116Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.94609383
117Menorrhagia (HP:0000132)1.94600476
118Chronic diarrhea (HP:0002028)1.93935234
119Abnormality of serum amino acid levels (HP:0003112)1.93713290
120Hematochezia (HP:0002573)1.93687257
121Osteolytic defects of the phalanges of the hand (HP:0009771)1.93588621
122Osteolytic defects of the hand bones (HP:0009699)1.93588621
123Protrusio acetabuli (HP:0003179)1.92004084
124Recurrent cutaneous fungal infections (HP:0011370)1.91536186
125Chronic mucocutaneous candidiasis (HP:0002728)1.91536186
126Metabolic acidosis (HP:0001942)1.90551087
127Vertebral compression fractures (HP:0002953)1.90351592
128Abnormality of purine metabolism (HP:0004352)1.90082474
129Epistaxis (HP:0000421)1.89916807
130Striae distensae (HP:0001065)1.89149918
131Abnormality of the prostate (HP:0008775)1.89145755
132Spontaneous hematomas (HP:0007420)1.87973743
133Spontaneous abortion (HP:0005268)1.87189339
134Loss of speech (HP:0002371)1.87107618
135Acne (HP:0001061)1.86769289
136Chest pain (HP:0100749)1.86090668
137Joint stiffness (HP:0001387)1.85990646
138Pulmonary embolism (HP:0002204)1.85175853
139Cellulitis (HP:0100658)1.84789293
140Recurrent bacterial skin infections (HP:0005406)1.84405157
141Abnormality of the pleura (HP:0002103)1.84257134
142Obstructive lung disease (HP:0006536)1.84000457
143Chronic obstructive pulmonary disease (HP:0006510)1.84000457
144Irritability (HP:0000737)1.83505205
145Renal cortical cysts (HP:0000803)1.82542453
146Abnormality of secondary sexual hair (HP:0009888)1.82203912
147Abnormality of the axillary hair (HP:0100134)1.82203912
148Cervical subluxation (HP:0003308)1.81743739
149Paraparesis (HP:0002385)1.81506067
150Vascular tortuosity (HP:0004948)1.81425027
151IgM deficiency (HP:0002850)1.80170518
152Vascular calcification (HP:0004934)1.80086878
153Hemorrhage of the eye (HP:0011885)1.79930265
154Colitis (HP:0002583)1.79692936
155Enlarged kidneys (HP:0000105)1.78964511
156Leukocytosis (HP:0001974)1.76361463
157Xerostomia (HP:0000217)1.76033687
158Lethargy (HP:0001254)1.75889455
159Increased IgM level (HP:0003496)1.75121869
160Thrombophlebitis (HP:0004418)1.74736139
161Abnormality of nucleobase metabolism (HP:0010932)1.74550625
162Eczematoid dermatitis (HP:0000976)1.74092049
163Vasculitis (HP:0002633)1.73847735

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN13.30814284
2BCKDK3.12827630
3MAP4K12.79833169
4FGFR42.70635652
5SIK12.56965820
6INSRR2.49101640
7TIE12.44453215
8TYK22.41829704
9MAPK152.36908634
10KIT2.35860357
11TAOK32.33160760
12TNIK2.30028829
13IRAK32.21708060
14KDR2.13618176
15MAP3K142.08960742
16RIPK42.08541826
17TBK11.92390286
18EPHB11.91353563
19TGFBR21.90129301
20CSF1R1.81833877
21IKBKE1.79272562
22IRAK41.73441201
23BLK1.72714661
24JAK31.72209957
25FLT31.65561823
26JAK11.63179888
27PIK3CG1.57249925
28TEC1.55494325
29NEK91.51383237
30RIPK11.50075719
31BTK1.46812008
32PRPF4B1.42020263
33MUSK1.41169180
34NLK1.38875013
35TXK1.34820593
36IRAK11.33030509
37ZAP701.32145622
38MAP3K131.22025300
39SYK1.19512664
40GRK71.15778891
41ITK1.12999682
42BMPR1B1.08571926
43LYN1.07305157
44MAPK111.04987424
45LMTK21.00773974
46CSK0.99699426
47PRKCQ0.98294409
48DDR20.97696964
49FGFR30.96835402
50MAP3K30.96509860
51EPHA30.93735734
52JAK20.91430081
53CDC42BPA0.91033513
54ACVR1B0.90880200
55FGFR20.87921303
56LCK0.85284162
57IRAK20.83694423
58GRK10.82831293
59FRK0.82293660
60HIPK20.77668466
61FER0.74632722
62PRKCH0.73606567
63IGF1R0.72842581
64MAPK120.72057455
65MOS0.71438618
66SCYL20.70693394
67HCK0.70376441
68PDGFRB0.69904169
69FES0.69797826
70MAP4K20.69481284
71IKBKB0.68343757
72GRK60.67373652
73NME20.67045676
74DYRK1B0.67039841
75PRKG20.66995539
76CAMKK20.66317630
77PTK60.65209468
78PDGFRA0.64203837
79MAPK70.62753990
80MAP3K110.61938154
81PRKAA20.60476884
82TGFBR10.59721171
83MAP3K10.58147255
84MAP3K20.57549127
85PHKG10.57306191
86PHKG20.57306191
87TNK20.55167853
88MAP2K20.54001515
89CDK60.52532805
90PRKD10.51822377
91TRPM70.51717562
92DMPK0.51350188
93GRK50.51317720
94CHUK0.50964158
95MAP2K30.49244696
96FGR0.48895388
97OXSR10.48770608
98PRKD20.47368309
99LRRK20.47336073
100CSNK1G10.46595674
101CDK30.46574600
102STK160.46502100
103MATK0.46285304
104CAMK1D0.45653434
105MAPK40.45297975
106NUAK10.45204628
107PIK3CA0.45023349
108PKN10.44588667
109MAP3K70.43970220
110ERBB40.43935488
111STK390.43590355
112YES10.43316559
113PRKCD0.42982158
114CAMKK10.41957795
115MAPKAPK50.41901769
116MAPKAPK20.41660159
117PDK10.40605778
118MAP2K60.40137218
119ADRBK20.39039843
120TRIB30.38597533
121MAP3K60.38176254
122MST40.38149105
123ABL10.38017090
124MET0.37498314
125RET0.37298170
126PRKACG0.37067697
127MYLK0.36442455
128PAK20.34968263
129PDPK10.34905452
130PINK10.34621924
131MARK20.34201200
132FYN0.33432049
133BMPR20.32711948
134CAMK2G0.31975959

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009104.02578611
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.74682272
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.77356920
4Fatty acid degradation_Homo sapiens_hsa000712.75207913
5Complement and coagulation cascades_Homo sapiens_hsa046102.55298263
6Allograft rejection_Homo sapiens_hsa053302.52508015
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50502796
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.50339165
9Graft-versus-host disease_Homo sapiens_hsa053322.46186016
10Tryptophan metabolism_Homo sapiens_hsa003802.40181267
11Autoimmune thyroid disease_Homo sapiens_hsa053202.38122663
12Peroxisome_Homo sapiens_hsa041462.28836855
13Caffeine metabolism_Homo sapiens_hsa002322.27333726
14Fatty acid metabolism_Homo sapiens_hsa012122.20331307
15Asthma_Homo sapiens_hsa053102.18873973
16Maturity onset diabetes of the young_Homo sapiens_hsa049502.05555825
17Histidine metabolism_Homo sapiens_hsa003402.00380708
18Sulfur metabolism_Homo sapiens_hsa009201.99950009
19PPAR signaling pathway_Homo sapiens_hsa033201.99813075
20Type I diabetes mellitus_Homo sapiens_hsa049401.99534283
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.98167217
22Staphylococcus aureus infection_Homo sapiens_hsa051501.96526337
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.94282928
24Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.91840145
25Propanoate metabolism_Homo sapiens_hsa006401.91395490
26Arginine biosynthesis_Homo sapiens_hsa002201.91162337
27Fatty acid elongation_Homo sapiens_hsa000621.90290669
28Butanoate metabolism_Homo sapiens_hsa006501.78678262
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.77561768
30Steroid biosynthesis_Homo sapiens_hsa001001.75610596
31Chemical carcinogenesis_Homo sapiens_hsa052041.69458748
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62041687
33Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60224738
34Cyanoamino acid metabolism_Homo sapiens_hsa004601.57934247
35Steroid hormone biosynthesis_Homo sapiens_hsa001401.56014652
36ABC transporters_Homo sapiens_hsa020101.54855149
37Folate biosynthesis_Homo sapiens_hsa007901.46150988
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.44041249
39beta-Alanine metabolism_Homo sapiens_hsa004101.42264218
40Rheumatoid arthritis_Homo sapiens_hsa053231.39848653
41Fatty acid biosynthesis_Homo sapiens_hsa000611.32140663
42Tuberculosis_Homo sapiens_hsa051521.26255925
43Viral myocarditis_Homo sapiens_hsa054161.23214775
44Retinol metabolism_Homo sapiens_hsa008301.22510669
45Arachidonic acid metabolism_Homo sapiens_hsa005901.21587803
46Primary immunodeficiency_Homo sapiens_hsa053401.20527291
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.20495641
48Starch and sucrose metabolism_Homo sapiens_hsa005001.20223783
49Toxoplasmosis_Homo sapiens_hsa051451.18321583
50Bile secretion_Homo sapiens_hsa049761.17498555
51Drug metabolism - other enzymes_Homo sapiens_hsa009831.17092460
52Selenocompound metabolism_Homo sapiens_hsa004501.12243630
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.11426240
54Other glycan degradation_Homo sapiens_hsa005111.09462263
55Phenylalanine metabolism_Homo sapiens_hsa003601.04832142
56Protein export_Homo sapiens_hsa030601.03537387
57NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02846762
58Tyrosine metabolism_Homo sapiens_hsa003501.02805984
59Vitamin digestion and absorption_Homo sapiens_hsa049771.01009505
60Influenza A_Homo sapiens_hsa051640.96620590
61Phagosome_Homo sapiens_hsa041450.92256851
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.92073238
63Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91487085
64Jak-STAT signaling pathway_Homo sapiens_hsa046300.91022355
65TNF signaling pathway_Homo sapiens_hsa046680.89215658
66Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.89107020
67Pyruvate metabolism_Homo sapiens_hsa006200.87588722
68* Lysosome_Homo sapiens_hsa041420.87202433
69Herpes simplex infection_Homo sapiens_hsa051680.86837942
70Renin-angiotensin system_Homo sapiens_hsa046140.86409684
71Sulfur relay system_Homo sapiens_hsa041220.85531331
72Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.84622190
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83230916
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.78828393
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.78508517
76Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76359420
77Arginine and proline metabolism_Homo sapiens_hsa003300.75996578
78Hepatitis C_Homo sapiens_hsa051600.75130536
79Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.71990471
80Amoebiasis_Homo sapiens_hsa051460.70826597
81Fat digestion and absorption_Homo sapiens_hsa049750.70135946
82Platelet activation_Homo sapiens_hsa046110.69979229
83Glycerolipid metabolism_Homo sapiens_hsa005610.69521876
84Leukocyte transendothelial migration_Homo sapiens_hsa046700.69446554
85Chemokine signaling pathway_Homo sapiens_hsa040620.67858834
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65949466
87Legionellosis_Homo sapiens_hsa051340.58480896
88Intestinal immune network for IgA production_Homo sapiens_hsa046720.58093436
89Acute myeloid leukemia_Homo sapiens_hsa052210.57997175
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.56511789
91Adipocytokine signaling pathway_Homo sapiens_hsa049200.56088366
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.55782058
93B cell receptor signaling pathway_Homo sapiens_hsa046620.55468741
94Carbon metabolism_Homo sapiens_hsa012000.54796562
95Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.53125045
96Malaria_Homo sapiens_hsa051440.52431244
97Protein digestion and absorption_Homo sapiens_hsa049740.51006185
98Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.50155858
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49855663
100Mineral absorption_Homo sapiens_hsa049780.48249114
101Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.47644831
102Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.45951991
103AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45946707
104Pentose phosphate pathway_Homo sapiens_hsa000300.45454680
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.45318522
106Glutathione metabolism_Homo sapiens_hsa004800.44419320
107NF-kappa B signaling pathway_Homo sapiens_hsa040640.44349391
108Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.43751559
109Prion diseases_Homo sapiens_hsa050200.42517656
110Renin secretion_Homo sapiens_hsa049240.41284395
111Ether lipid metabolism_Homo sapiens_hsa005650.40848789
112Biosynthesis of amino acids_Homo sapiens_hsa012300.40325172
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39710063
114Metabolic pathways_Homo sapiens_hsa011000.39313194
115Vitamin B6 metabolism_Homo sapiens_hsa007500.38816475
116T cell receptor signaling pathway_Homo sapiens_hsa046600.35992692
117Hepatitis B_Homo sapiens_hsa051610.35908811
118Pancreatic secretion_Homo sapiens_hsa049720.35525760
119Lysine degradation_Homo sapiens_hsa003100.35496855
120Insulin resistance_Homo sapiens_hsa049310.35411131
121Hematopoietic cell lineage_Homo sapiens_hsa046400.33732020
122Salmonella infection_Homo sapiens_hsa051320.32770752
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.32225957
124Antigen processing and presentation_Homo sapiens_hsa046120.30516273
125Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.30344849
126Leishmaniasis_Homo sapiens_hsa051400.30255217
127Glycerophospholipid metabolism_Homo sapiens_hsa005640.29375653
128Linoleic acid metabolism_Homo sapiens_hsa005910.28931330
129Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28553823
130African trypanosomiasis_Homo sapiens_hsa051430.26839821
131Sphingolipid metabolism_Homo sapiens_hsa006000.25693111
132Osteoclast differentiation_Homo sapiens_hsa043800.25643642
133RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.24581402
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.24317948
135Galactose metabolism_Homo sapiens_hsa000520.23273383
136N-Glycan biosynthesis_Homo sapiens_hsa005100.22946623
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.22675289
138Pertussis_Homo sapiens_hsa051330.22332225
139Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.22276392
140Measles_Homo sapiens_hsa051620.18268593
141Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.16916964
142Regulation of autophagy_Homo sapiens_hsa041400.15252087

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