CTSZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.84495573
2positive regulation by symbiont of host defense response (GO:0052509)5.49502017
3modulation by symbiont of host defense response (GO:0052031)5.49502017
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.49502017
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.49502017
6positive regulation by organism of defense response of other organism involved in symbiotic interact5.49502017
7modulation by symbiont of host immune response (GO:0052553)5.49502017
8neutrophil activation involved in immune response (GO:0002283)5.39577918
9glycosphingolipid catabolic process (GO:0046479)4.81351636
10regulation of interferon-beta biosynthetic process (GO:0045357)4.79231720
11positive regulation of interferon-alpha production (GO:0032727)4.79145015
12macrophage activation involved in immune response (GO:0002281)4.54713453
13respiratory burst (GO:0045730)4.53816054
14regulation of interferon-alpha production (GO:0032647)4.51479433
15response to peptidoglycan (GO:0032494)4.48536741
16immunoglobulin mediated immune response (GO:0016064)4.40152637
17glycolipid catabolic process (GO:0019377)4.32765879
18oligosaccharide catabolic process (GO:0009313)4.30916091
19positive regulation of interleukin-8 biosynthetic process (GO:0045416)4.26903770
20cellular response to thyroid hormone stimulus (GO:0097067)4.21140127
21antigen processing and presentation of endogenous antigen (GO:0019883)4.08173248
22hydrogen peroxide biosynthetic process (GO:0050665)3.99074652
23amino sugar catabolic process (GO:0046348)3.93234550
24production of molecular mediator involved in inflammatory response (GO:0002532)3.91587237
25positive regulation of antigen processing and presentation (GO:0002579)3.86535115
26antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.84673584
27antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.84673584
28reactive oxygen species biosynthetic process (GO:1903409)3.80408642
29ceramide catabolic process (GO:0046514)3.78428354
30lipopolysaccharide-mediated signaling pathway (GO:0031663)3.67777427
31granulocyte activation (GO:0036230)3.67303787
32microglial cell activation (GO:0001774)3.62422945
33response to host immune response (GO:0052572)3.55597969
34response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.55597969
35neutrophil activation (GO:0042119)3.54560776
36positive regulation of interferon-beta production (GO:0032728)3.49808261
37macrophage activation (GO:0042116)3.48666694
38NIK/NF-kappaB signaling (GO:0038061)3.47973209
39response to thyroid hormone (GO:0097066)3.40113516
40regulation of vitamin D biosynthetic process (GO:0060556)3.38958314
41myeloid cell activation involved in immune response (GO:0002275)3.38556743
42regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.34471596
43B cell mediated immunity (GO:0019724)3.33744108
44detection of molecule of bacterial origin (GO:0032490)3.32921764
45positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.32762648
46regulation of antigen processing and presentation (GO:0002577)3.32168301
47virion attachment to host cell (GO:0019062)3.31724773
48adhesion of symbiont to host cell (GO:0044650)3.31724773
49regulation of dendritic cell antigen processing and presentation (GO:0002604)3.30523091
50barbed-end actin filament capping (GO:0051016)3.28738687
51natural killer cell mediated cytotoxicity (GO:0042267)3.27593950
52natural killer cell mediated immunity (GO:0002228)3.27593950
53superoxide anion generation (GO:0042554)3.26078817
54response to muramyl dipeptide (GO:0032495)3.25127100
55N-acetylneuraminate metabolic process (GO:0006054)3.24285486
56membrane lipid catabolic process (GO:0046466)3.22504066
57positive regulation of chemokine biosynthetic process (GO:0045080)3.21773366
58negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)3.20061460
59regulation of mononuclear cell migration (GO:0071675)3.18713005
60regulation of cholesterol storage (GO:0010885)3.17370041
61positive regulation of cellular amide metabolic process (GO:0034250)3.16751859
62leukocyte mediated cytotoxicity (GO:0001909)3.16518746
63negative regulation of cell killing (GO:0031342)3.15808325
64negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.15808325
65cellular response to type I interferon (GO:0071357)3.14660079
66type I interferon signaling pathway (GO:0060337)3.14660079
67sphingolipid catabolic process (GO:0030149)3.14415862
68regulation of B cell receptor signaling pathway (GO:0050855)3.14019897
69response to host defenses (GO:0052200)3.13560686
70response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.13560686
71response to host (GO:0075136)3.13560686
72regulation of podosome assembly (GO:0071801)3.13460325
73detection of other organism (GO:0098543)3.12922421
74response to type I interferon (GO:0034340)3.11564379
75regulation of macrophage chemotaxis (GO:0010758)3.10935007
76protein localization to endosome (GO:0036010)3.08635116
77positive regulation of leukocyte degranulation (GO:0043302)3.08070114
78negative regulation of erythrocyte differentiation (GO:0045647)3.07465897
79positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)3.06561871
80negative regulation of nitric oxide biosynthetic process (GO:0045019)3.03252130
81interferon-gamma-mediated signaling pathway (GO:0060333)3.02374227
82germinal center formation (GO:0002467)3.02253531
83low-density lipoprotein particle clearance (GO:0034383)3.00978596
84positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.99864282
85adhesion of symbiont to host (GO:0044406)2.99856630
86positive regulation of mast cell activation (GO:0033005)2.98822896
87regulation of leukocyte degranulation (GO:0043300)2.98504202
88detection of external biotic stimulus (GO:0098581)2.96874937
89cellular response to zinc ion (GO:0071294)2.96681918
90cellular response to interferon-beta (GO:0035458)2.96015749
91regulation of cytokine secretion involved in immune response (GO:0002739)2.95925832
92regulation of interleukin-8 biosynthetic process (GO:0045414)2.95505170
93myeloid dendritic cell differentiation (GO:0043011)2.94725214
94positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.93837558
95monocyte chemotaxis (GO:0002548)2.92592974
96Arp2/3 complex-mediated actin nucleation (GO:0034314)2.92508400
97regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.92380830
98negative regulation of cytokine production involved in immune response (GO:0002719)2.92354716
99regulation of mast cell degranulation (GO:0043304)2.92162603
100T-helper 1 type immune response (GO:0042088)2.91572220
101detection of bacterium (GO:0016045)2.89567062
102positive regulation of B cell differentiation (GO:0045579)2.89432914
103regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.87177080
104regulation of chemokine biosynthetic process (GO:0045073)2.86243680
105response to interferon-alpha (GO:0035455)2.85760699
106pinocytosis (GO:0006907)2.85303847
107regulation of vitamin metabolic process (GO:0030656)2.85226192
108cellular extravasation (GO:0045123)2.85012440
109regulation of membrane protein ectodomain proteolysis (GO:0051043)2.84088246
110negative regulation of myeloid cell apoptotic process (GO:0033033)2.83392348
111response to interferon-beta (GO:0035456)2.82863025
112mannose metabolic process (GO:0006013)2.82686770
113positive regulation of monocyte chemotaxis (GO:0090026)2.82400305
114defense response to protozoan (GO:0042832)2.82089050
115negative regulation of interleukin-17 production (GO:0032700)2.81810908
116neutrophil mediated immunity (GO:0002446)2.81751077
117myeloid dendritic cell activation (GO:0001773)2.79628430
118regulation of mast cell activation (GO:0033003)2.78830888
119positive regulation of mast cell activation involved in immune response (GO:0033008)2.78472953
120positive regulation of mast cell degranulation (GO:0043306)2.78472953
121myeloid leukocyte activation (GO:0002274)2.76683357
122response to protozoan (GO:0001562)2.75900543
123positive regulation of gamma-delta T cell activation (GO:0046645)2.75497528
124regulation of T-helper 1 cell differentiation (GO:0045625)2.74909838
125regulation of myeloid leukocyte mediated immunity (GO:0002886)2.74670007
126regulation of mast cell activation involved in immune response (GO:0033006)2.74546261
127positive regulation of interleukin-12 production (GO:0032735)2.74429801
128regulation of superoxide anion generation (GO:0032928)2.74087618
129positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.73441907
130regulation of T-helper 2 cell differentiation (GO:0045628)2.72373963
131regulation of monocyte chemotaxis (GO:0090025)2.71597091
132I-kappaB phosphorylation (GO:0007252)2.71173851
133positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.70966901
134dendritic cell differentiation (GO:0097028)2.70863559
135negative regulation of mast cell activation (GO:0033004)2.70099656
136positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.69695576
137negative regulation of lipid storage (GO:0010888)2.67534423
138positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.66720732
139negative regulation of interleukin-12 production (GO:0032695)2.65487133
140regulation of interleukin-12 biosynthetic process (GO:0045075)2.65391973
141regulation of interferon-beta production (GO:0032648)2.64769537
142apoptotic cell clearance (GO:0043277)2.63425981
143positive regulation of chemokine production (GO:0032722)2.63289027
144peptide catabolic process (GO:0043171)2.63052418
145negative regulation of growth of symbiont involved in interaction with host (GO:0044146)2.62863570
146modulation of growth of symbiont involved in interaction with host (GO:0044144)2.62863570
147regulation of growth of symbiont in host (GO:0044126)2.62863570
148negative regulation of growth of symbiont in host (GO:0044130)2.62863570
149cellular response to interferon-gamma (GO:0071346)2.61969107
150cellular response to lipopolysaccharide (GO:0071222)2.60645225

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.46082960
2* IRF8_22096565_ChIP-ChIP_GC-B_Human6.13008988
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.03665164
4* IRF8_27001747_Chip-Seq_BMDM_Mouse4.10859260
5* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.74040020
6IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.71901432
7* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.45364095
8IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.42941085
9Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.19960440
10MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.03678396
11MYB_21317192_ChIP-Seq_ERMYB_Mouse2.87068748
12NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.77614336
13ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.70490546
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.69919117
15* SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61972676
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.56954698
17FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.24774800
18BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22006100
19STAT4_19710469_ChIP-ChIP_TH1__Mouse2.19812246
20* SPI1_23547873_ChIP-Seq_NB4_Human2.14962397
21STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.06000725
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.04020547
23RXR_22158963_ChIP-Seq_LIVER_Mouse1.98860576
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98021241
25STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.95724608
26PPARA_22158963_ChIP-Seq_LIVER_Mouse1.91271475
27* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.86122491
28PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.80714579
29EGR1_23403033_ChIP-Seq_LIVER_Mouse1.78429500
30RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.76794318
31PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.76604130
32CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.74267407
33ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.70048416
34STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69788714
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68910391
36* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.66603900
37CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65600640
38* VDR_24763502_ChIP-Seq_THP-1_Human1.65554690
39RUNX1_22412390_ChIP-Seq_EML_Mouse1.61262070
40LXR_22158963_ChIP-Seq_LIVER_Mouse1.59395705
41PU_27001747_Chip-Seq_BMDM_Mouse1.57393103
42VDR_21846776_ChIP-Seq_THP-1_Human1.56640704
43CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.54528591
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.51293395
45MYB_26560356_Chip-Seq_TH2_Human1.50511498
46SPI1_23127762_ChIP-Seq_K562_Human1.48122082
47KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.47016645
48GATA1_22025678_ChIP-Seq_K562_Human1.45548398
49MAF_26560356_Chip-Seq_TH1_Human1.44159338
50CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.41845927
51KDM2B_26808549_Chip-Seq_DND41_Human1.41761199
52CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.40370390
53CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35227076
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.34234243
55STAT6_21828071_ChIP-Seq_BEAS2B_Human1.34206722
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.31385919
57SCL_19346495_ChIP-Seq_HPC-7_Human1.30543041
58VDR_24787735_ChIP-Seq_THP-1_Human1.28684292
59PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.28490300
60PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.26524368
61RARG_19884340_ChIP-ChIP_MEFs_Mouse1.25775243
62PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25052113
63CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24757054
64RACK7_27058665_Chip-Seq_MCF-7_Human1.23446266
65* MYB_26560356_Chip-Seq_TH1_Human1.23375971
66E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22932830
67GATA1_19941826_ChIP-Seq_K562_Human1.22084430
68FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.21982127
69SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.21155139
70TFEB_21752829_ChIP-Seq_HELA_Human1.20561849
71RUNX_20019798_ChIP-Seq_JUKART_Human1.17362477
72TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17275164
73CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.17098864
74LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.16103504
75TP63_17297297_ChIP-ChIP_HaCaT_Human1.15098021
76GATA2_22383799_ChIP-Seq_G1ME_Mouse1.14678056
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.10332234
78KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.09480165
79FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.08639397
80KDM2B_26808549_Chip-Seq_K562_Human1.07232332
81SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04250803
82GATA3_26560356_Chip-Seq_TH2_Human1.04181532
83GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04157838
84* ELK3_25401928_ChIP-Seq_HUVEC_Human1.04004281
85SRY_22984422_ChIP-ChIP_TESTIS_Rat1.02443182
86GATA1_22383799_ChIP-Seq_G1ME_Mouse1.02028611
87GATA3_27048872_Chip-Seq_THYMUS_Human1.01142765
88BCOR_27268052_Chip-Seq_Bcells_Human1.00623104
89BCL6_27268052_Chip-Seq_Bcells_Human0.98299837
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98168487
91NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.97664849
92KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.97574093
93UTX_26944678_Chip-Seq_JUKART_Human0.96480338
94TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.96314105
95TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95548679
96GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94971029
97GATA2_21666600_ChIP-Seq_HMVEC_Human0.94539838
98CTCF_27219007_Chip-Seq_ERYTHROID_Human0.91868092
99LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.90866808
100ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.85173039
101MAF_26560356_Chip-Seq_TH2_Human0.83517239
102CLOCK_20551151_ChIP-Seq_293T_Human0.83242815
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.82765175
104* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.82704540
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81093465
106EGR1_19032775_ChIP-ChIP_M12_Human0.80822560
107MYC_22102868_ChIP-Seq_BL_Human0.79331786
108PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78133082
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.77473143
110ERG_20887958_ChIP-Seq_HPC-7_Mouse0.76613166
111SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.75679067
112SPI1_20517297_ChIP-Seq_HL60_Human0.75154554
113LXR_22292898_ChIP-Seq_THP-1_Human0.74422931
114TCF7_22412390_ChIP-Seq_EML_Mouse0.74383645
115* SOX2_20726797_ChIP-Seq_SW620_Human0.73907057
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.73155789
117GATA1_19941827_ChIP-Seq_MEL_Mouse0.73037979
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.71076181

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.47017551
2MP0003436_decreased_susceptibility_to3.63776697
3MP0005058_abnormal_lysosome_morphology3.57049977
4MP0009785_altered_susceptibility_to3.15241186
5MP0002148_abnormal_hypersensitivity_rea3.11099060
6MP0006082_CNS_inflammation3.09436292
7MP0002419_abnormal_innate_immunity3.04899845
8MP0003303_peritoneal_inflammation2.93003434
9MP0009840_abnormal_foam_cell2.89834098
10MP0005000_abnormal_immune_tolerance2.78523131
11MP0005025_abnormal_response_to2.68414611
12MP0003191_abnormal_cellular_cholesterol2.55269872
13MP0005387_immune_system_phenotype2.46892979
14MP0001790_abnormal_immune_system2.46892979
15MP0000685_abnormal_immune_system2.45563953
16MP0003724_increased_susceptibility_to2.43126448
17MP0003172_abnormal_lysosome_physiology2.41019151
18MP0002452_abnormal_antigen_presenting2.40874792
19MP0005671_abnormal_response_to2.25145653
20MP0001800_abnormal_humoral_immune2.18980038
21MP0002723_abnormal_immune_serum2.17932405
22MP0005451_abnormal_body_composition2.12767218
23MP0004510_myositis2.11234933
24MP0005464_abnormal_platelet_physiology2.09949855
25MP0001533_abnormal_skeleton_physiology2.05445420
26MP0001819_abnormal_immune_cell1.96422835
27MP0002420_abnormal_adaptive_immunity1.93497063
28MP0001853_heart_inflammation1.83728068
29MP0001845_abnormal_inflammatory_respons1.80948334
30MP0008469_abnormal_protein_level1.78179405
31MP0009764_decreased_sensitivity_to1.73829139
32MP0002405_respiratory_system_inflammati1.71217554
33MP0004947_skin_inflammation1.65475549
34MP0000343_altered_response_to1.64203652
35MP0003806_abnormal_nucleotide_metabolis1.62368016
36MP0003075_altered_response_to1.57183086
37MP0008438_abnormal_cutaneous_collagen1.55487384
38MP0000604_amyloidosis1.54045898
39MP0003186_abnormal_redox_activity1.46031264
40MP0009333_abnormal_splenocyte_physiolog1.45475116
41* MP0003448_altered_tumor_morphology1.42865046
42MP0000716_abnormal_immune_system1.40960637
43MP0002998_abnormal_bone_remodeling1.40899074
44MP0003329_amyloid_beta_deposits1.39692192
45MP0010155_abnormal_intestine_physiology1.37460043
46MP0005310_abnormal_salivary_gland1.36333215
47MP0002139_abnormal_hepatobiliary_system1.32350884
48MP0002006_tumorigenesis1.28649632
49MP0003195_calcinosis1.28621312
50MP0006054_spinal_hemorrhage1.28469713
51MP0004782_abnormal_surfactant_physiolog1.26271750
52MP0008004_abnormal_stomach_pH1.26241522
53MP0005166_decreased_susceptibility_to1.26100895
54MP0003690_abnormal_glial_cell1.25903869
55MP0002877_abnormal_melanocyte_morpholog1.25616234
56MP0005360_urolithiasis1.24544694
57MP0002398_abnormal_bone_marrow1.23598246
58MP0002166_altered_tumor_susceptibility1.23084750
59MP0000689_abnormal_spleen_morphology1.21605201
60MP0003300_gastrointestinal_ulcer1.18720974
61MP0003183_abnormal_peptide_metabolism1.17866739
62MP0002429_abnormal_blood_cell1.16291705
63MP0003705_abnormal_hypodermis_morpholog1.16061188
64MP0002138_abnormal_hepatobiliary_system1.15317147
65MP0005257_abnormal_intraocular_pressure1.13402665
66MP0003091_abnormal_cell_migration1.11054239
67MP0005164_abnormal_response_to1.09147851
68MP0003279_aneurysm1.09115106
69* MP0000858_altered_metastatic_potential1.09067168
70MP0001545_abnormal_hematopoietic_system1.06588080
71MP0005397_hematopoietic_system_phenotyp1.06588080
72MP0009763_increased_sensitivity_to1.06507247
73MP0000920_abnormal_myelination1.05950846
74MP0002722_abnormal_immune_system1.05142094
75MP0002254_reproductive_system_inflammat1.04643278
76MP0005167_abnormal_blood-brain_barrier1.03028448
77MP0009278_abnormal_bone_marrow1.02613219
78MP0005083_abnormal_biliary_tract0.99115495
79MP0005390_skeleton_phenotype0.98991727
80MP0003566_abnormal_cell_adhesion0.97401655
81MP0000609_abnormal_liver_physiology0.96010889
82MP0003656_abnormal_erythrocyte_physiolo0.95268878
83MP0002933_joint_inflammation0.94946529
84MP0005165_increased_susceptibility_to0.92438421
85MP0010329_abnormal_lipoprotein_level0.91229611
86MP0005319_abnormal_enzyme/_coenzyme0.89622116
87MP0001542_abnormal_bone_strength0.87786744
88MP0000249_abnormal_blood_vessel0.85978624
89MP0000371_diluted_coat_color0.83663465
90MP0001849_ear_inflammation0.83178092
91MP0002136_abnormal_kidney_physiology0.82163794
92MP0000465_gastrointestinal_hemorrhage0.81547830
93MP0001958_emphysema0.80847322
94MP0001663_abnormal_digestive_system0.76355234
95MP0005365_abnormal_bile_salt0.75925753
96MP0001851_eye_inflammation0.75542264
97MP0005584_abnormal_enzyme/coenzyme_acti0.75188413
98MP0000598_abnormal_liver_morphology0.74564825
99MP0004883_abnormal_blood_vessel0.73864500
100MP0005076_abnormal_cell_differentiation0.73582040
101MP0003795_abnormal_bone_structure0.73323739
102MP0003634_abnormal_glial_cell0.73061208
103MP0009643_abnormal_urine_homeostasis0.72883203
104MP0000569_abnormal_digit_pigmentation0.69893526
105MP0003252_abnormal_bile_duct0.69479503
106MP0008874_decreased_physiological_sensi0.69434101
107MP0005023_abnormal_wound_healing0.68192399
108MP0005085_abnormal_gallbladder_physiolo0.68102443
109MP0002332_abnormal_exercise_endurance0.67344931
110MP0003828_pulmonary_edema0.66486476
111MP0003453_abnormal_keratinocyte_physiol0.66165044
112MP0002277_abnormal_respiratory_mucosa0.65905791
113MP0008260_abnormal_autophagy0.65181991
114MP0008875_abnormal_xenobiotic_pharmacok0.65057872
115MP0004019_abnormal_vitamin_homeostasis0.64191292
116MP0002090_abnormal_vision0.63954093
117MP0000490_abnormal_crypts_of0.62657175
118MP0005595_abnormal_vascular_smooth0.61796269
119MP0005647_abnormal_sex_gland0.58958802
120MP0009765_abnormal_xenobiotic_induced0.58266438

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.51217416
2Eczematoid dermatitis (HP:0000976)6.16844976
3Recurrent bacterial skin infections (HP:0005406)6.04179432
4Recurrent gram-negative bacterial infections (HP:0005420)5.93344998
5Systemic lupus erythematosus (HP:0002725)5.18031478
6Vacuolated lymphocytes (HP:0001922)5.16210541
7Abnormality of macrophages (HP:0004311)4.82715753
8Increased cerebral lipofuscin (HP:0011813)4.49446244
9Increased neuronal autofluorescent lipopigment (HP:0002074)4.03099624
10Mediastinal lymphadenopathy (HP:0100721)3.93051671
11Autoimmune thrombocytopenia (HP:0001973)3.88777697
12Dysostosis multiplex (HP:0000943)3.84858255
13Abnormality of glycolipid metabolism (HP:0010969)3.84082515
14Abnormality of liposaccharide metabolism (HP:0010968)3.84082515
15Abnormality of glycosphingolipid metabolism (HP:0004343)3.84082515
16Recurrent skin infections (HP:0001581)3.76880910
17Glomerulonephritis (HP:0000099)3.73746655
18Elevated erythrocyte sedimentation rate (HP:0003565)3.71245110
19Axonal loss (HP:0003447)3.63390162
20Gingivitis (HP:0000230)3.58867021
21Neurofibrillary tangles (HP:0002185)3.58269413
22Mutism (HP:0002300)3.51047933
23Myositis (HP:0100614)3.39889839
24Urinary glycosaminoglycan excretion (HP:0003541)3.21384131
25Mucopolysacchariduria (HP:0008155)3.21384131
26Nuclear cataract (HP:0100018)3.20167629
27Chronic obstructive pulmonary disease (HP:0006510)3.19324422
28Obstructive lung disease (HP:0006536)3.19324422
29Orchitis (HP:0100796)3.11027049
30Recurrent fungal infections (HP:0002841)3.10512639
31Myocardial infarction (HP:0001658)3.10242989
32Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.03224579
33Abnormality of mucopolysaccharide metabolism (HP:0011020)2.97340177
34Abnormality of polysaccharide metabolism (HP:0011012)2.97340177
35Abnormality of glycosaminoglycan metabolism (HP:0004371)2.97340177
36Complement deficiency (HP:0004431)2.93604801
37Basal ganglia calcification (HP:0002135)2.89404307
38Disinhibition (HP:0000734)2.87678064
39Interstitial pulmonary disease (HP:0006530)2.87447434
40Abnormality of complement system (HP:0005339)2.85511931
41Joint hemorrhage (HP:0005261)2.82727181
42Periodontitis (HP:0000704)2.82216119
43Pustule (HP:0200039)2.82118847
44Apathy (HP:0000741)2.78198747
45Diminished motivation (HP:0000745)2.73285474
46Vasculitis (HP:0002633)2.71898178
47Recurrent viral infections (HP:0004429)2.70663161
48Cerebral inclusion bodies (HP:0100314)2.69918109
49Optic neuritis (HP:0100653)2.69168258
50Retrobulbar optic neuritis (HP:0100654)2.69168258
51Cellulitis (HP:0100658)2.67179011
52Neuronal loss in central nervous system (HP:0002529)2.62138102
53Urticaria (HP:0001025)2.59824169
54Nephritis (HP:0000123)2.55628111
55Tetraparesis (HP:0002273)2.53569719
56Hepatosplenomegaly (HP:0001433)2.52408872
57Chronic otitis media (HP:0000389)2.52061204
58Loss of speech (HP:0002371)2.51422924
59Stomatitis (HP:0010280)2.48355169
60Agnosia (HP:0010524)2.48182830
61Osteomyelitis (HP:0002754)2.45347710
62Pathologic fracture (HP:0002756)2.41164120
63Progressive neurologic deterioration (HP:0002344)2.39707965
64Osteolytic defects of the phalanges of the hand (HP:0009771)2.39244692
65Osteolytic defects of the hand bones (HP:0009699)2.39244692
66Petechiae (HP:0000967)2.37477936
67Vertebral compression fractures (HP:0002953)2.37120653
68Recurrent pneumonia (HP:0006532)2.35792062
69Upper motor neuron abnormality (HP:0002127)2.35410896
70Thick nail (HP:0001805)2.33255069
71Malnutrition (HP:0004395)2.31917787
72Pulmonary infiltrates (HP:0002113)2.31406065
73Abnormality of the vasculature of the conjunctiva (HP:0008054)2.28477908
74Recurrent cutaneous fungal infections (HP:0011370)2.27898479
75Chronic mucocutaneous candidiasis (HP:0002728)2.27898479
76Asymmetric septal hypertrophy (HP:0001670)2.24481552
77Meningitis (HP:0001287)2.23451775
78Increased IgM level (HP:0003496)2.23366649
79Gingival bleeding (HP:0000225)2.23268657
80Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.23006741
81Inappropriate behavior (HP:0000719)2.22547711
82Hematochezia (HP:0002573)2.22263285
83Nausea (HP:0002018)2.21476938
84Metaphyseal irregularity (HP:0003025)2.19600564
85Poor head control (HP:0002421)2.17032548
86Personality changes (HP:0000751)2.15824452
87Arterial thrombosis (HP:0004420)2.15161916
88Amyloidosis (HP:0011034)2.12847565
89Dementia (HP:0000726)2.11580980
90Leukocytosis (HP:0001974)2.09932205
91Recurrent lower respiratory tract infections (HP:0002783)2.08705903
92Purpura (HP:0000979)2.07169089
93Bone pain (HP:0002653)2.06830467
94Hypergammaglobulinemia (HP:0010702)2.04130794
95Peritonitis (HP:0002586)2.03772523
96Prolonged neonatal jaundice (HP:0006579)2.02902847
97Spontaneous hematomas (HP:0007420)2.00417132
98Gastrointestinal infarctions (HP:0005244)1.98947300
99Peripheral demyelination (HP:0011096)1.98114894
100Xanthomatosis (HP:0000991)1.97022800
101Prostate neoplasm (HP:0100787)1.95449130
102Thrombocytosis (HP:0001894)1.94638926
103Abnormality of the lumbar spine (HP:0100712)1.93386789
104Colitis (HP:0002583)1.93325709
105Increased serum ferritin (HP:0003281)1.90687444
106Supranuclear gaze palsy (HP:0000605)1.88705986
107Cardiomegaly (HP:0001640)1.88518539
108Abnormality of the nasal mucosa (HP:0000433)1.87201997
109Restrictive lung disease (HP:0002091)1.86789801
110Abnormality of the periventricular white matter (HP:0002518)1.85548037
111Hemoptysis (HP:0002105)1.85089199
112Thoracic kyphosis (HP:0002942)1.82931725
113Epistaxis (HP:0000421)1.82612184
114Global brain atrophy (HP:0002283)1.80983750
115Conjunctival telangiectasia (HP:0000524)1.80190391
116Polyneuropathy (HP:0001271)1.80032734
117Gastrointestinal stroma tumor (HP:0100723)1.79802096
118J-shaped sella turcica (HP:0002680)1.78916322
119Abnormality of iron homeostasis (HP:0011031)1.78860615
120Esophageal varix (HP:0002040)1.78806435
121Hydroxyprolinuria (HP:0003080)1.76440349
122Abnormality of proline metabolism (HP:0010907)1.76440349
123Retinal atrophy (HP:0001105)1.76338809
124Premature loss of primary teeth (HP:0006323)1.76318919
125Increased CSF protein (HP:0002922)1.74673848
126Keratoconjunctivitis sicca (HP:0001097)1.74268154
127Thin bony cortex (HP:0002753)1.72863172
128Acrocyanosis (HP:0001063)1.72588002
129Spondylolisthesis (HP:0003302)1.72521750
130Protuberant abdomen (HP:0001538)1.68670462
131Segmental peripheral demyelination/remyelination (HP:0003481)1.65919200

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.87011475
2BLK3.65820549
3TBK13.65329241
4RIPK43.49747924
5TYK23.29956468
6ERN13.00753693
7IRAK42.97421745
8IRAK32.83412240
9PBK2.83393868
10MAP4K12.71307602
11PRPF4B2.55094537
12KIT2.55075794
13DDR22.32245043
14TAOK22.26703638
15IKBKB2.21941487
16IKBKE2.14640581
17JAK32.06931385
18PIM22.06269588
19TGFBR21.98173423
20NME21.92521803
21JAK11.86744073
22TAOK11.79580772
23NEK91.76984599
24CSF1R1.73423394
25ZAP701.62001279
26CDC42BPA1.57156372
27CSK1.48831110
28ABL21.43922584
29MST1R1.42035017
30TRIB31.41524522
31SYK1.39690873
32ACVR1B1.38887724
33BTK1.32490419
34TAOK31.31254243
35MAP3K131.26056758
36RPS6KA41.26011803
37CHUK1.25744327
38LYN1.20921054
39HCK1.19514613
40TXK1.16383979
41PKN21.14450206
42BMX1.13970105
43FGFR41.12023451
44JAK21.11934604
45STK101.11366973
46EPHB11.10445374
47MAP2K31.07064950
48TESK21.06978815
49TEC1.05887930
50PIM11.03713648
51MATK0.99038560
52LCK0.96920000
53LRRK20.93029214
54SCYL20.87331124
55ICK0.86421589
56MAP3K30.84843850
57PDGFRA0.82459685
58MAP3K110.81885314
59ARAF0.81665247
60FGR0.81485762
61SIK30.79672635
62PAK40.79252287
63MARK30.78175245
64IRAK20.77729671
65STK40.77066865
66PTK60.74633372
67FLT30.70887663
68PIK3CG0.70723826
69PRKCD0.70665919
70FES0.68788457
71EIF2AK20.68360211
72TRPM70.67854469
73TESK10.67594473
74ABL10.65614164
75GRK70.65197515
76MST40.65152070
77KDR0.65034186
78EGFR0.62906127
79MOS0.62753441
80PDK20.62590155
81ITK0.60447927
82RPS6KA20.59235346
83RIPK10.55737923
84KSR20.55328752
85ADRBK20.54927024
86TTN0.54582160
87CLK10.53254144
88MAP2K60.52143880
89EPHB20.50777928
90BMPR20.50716555
91MAPK70.50670060
92SIK10.49781218
93CAMK1D0.48037785
94SMG10.44526004
95EIF2AK10.43970933
96CDK60.43676473
97MAP3K100.43546286
98EPHA30.43432510
99MAPKAPK20.43399682
100FGFR30.42697830
101LIMK10.42045511
102TYRO30.41635265
103TNK20.40966701
104MAP3K50.40380224
105YES10.40033961
106EIF2AK30.39553340
107MARK20.38871327
108MAPK120.38730075
109MAP3K60.38706689
110PRKD20.38473754
111RPS6KA60.38385329
112STK30.37958313
113PDGFRB0.36957788
114TGFBR10.36262336
115MAP3K80.35060997
116LATS20.34401666
117GRK60.33726263
118SIK20.33422068
119PRKCQ0.33064997
120PRKG20.31591626
121IGF1R0.31276455
122FYN0.30947596
123DAPK30.29740459
124PDPK10.27970341
125MAPK40.27527600
126IRAK10.26727321
127RPS6KL10.26207365
128RPS6KC10.26207365
129CAMKK20.25449087
130MAP3K10.24900508
131PDK10.24157227

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.83048256
2Leishmaniasis_Homo sapiens_hsa051403.16473394
3* Lysosome_Homo sapiens_hsa041422.78111816
4Glycosaminoglycan degradation_Homo sapiens_hsa005312.60182452
5Other glycan degradation_Homo sapiens_hsa005112.55986494
6Toll-like receptor signaling pathway_Homo sapiens_hsa046202.53085016
7Legionellosis_Homo sapiens_hsa051342.47874483
8Pertussis_Homo sapiens_hsa051332.26071339
9Osteoclast differentiation_Homo sapiens_hsa043802.25414147
10Graft-versus-host disease_Homo sapiens_hsa053322.22564488
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.20522784
12Tuberculosis_Homo sapiens_hsa051522.15140243
13Malaria_Homo sapiens_hsa051442.14690579
14Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.13437679
15Phagosome_Homo sapiens_hsa041451.92726533
16Rheumatoid arthritis_Homo sapiens_hsa053231.90014614
17Complement and coagulation cascades_Homo sapiens_hsa046101.89919677
18Allograft rejection_Homo sapiens_hsa053301.87475242
19Antigen processing and presentation_Homo sapiens_hsa046121.81109686
20NOD-like receptor signaling pathway_Homo sapiens_hsa046211.80766981
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.74616377
22Measles_Homo sapiens_hsa051621.66968188
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.64201016
24Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61624318
25B cell receptor signaling pathway_Homo sapiens_hsa046621.47383065
26Influenza A_Homo sapiens_hsa051641.47305995
27Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.43325488
28Pentose and glucuronate interconversions_Homo sapiens_hsa000401.42878731
29Asthma_Homo sapiens_hsa053101.42307597
30TNF signaling pathway_Homo sapiens_hsa046681.40224066
31Salmonella infection_Homo sapiens_hsa051321.38903520
32Toxoplasmosis_Homo sapiens_hsa051451.36357663
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.27202801
34* Apoptosis_Homo sapiens_hsa042101.26448368
35Caffeine metabolism_Homo sapiens_hsa002321.22699198
36Herpes simplex infection_Homo sapiens_hsa051681.17224365
37Hematopoietic cell lineage_Homo sapiens_hsa046401.14885857
38African trypanosomiasis_Homo sapiens_hsa051431.12833102
39Shigellosis_Homo sapiens_hsa051311.12343319
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.10287510
41Type I diabetes mellitus_Homo sapiens_hsa049401.09444121
42Primary bile acid biosynthesis_Homo sapiens_hsa001201.07806999
43Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.02663505
44Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.00970920
45Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.99942619
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.99935275
47Bladder cancer_Homo sapiens_hsa052190.98490791
48Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.97505906
49Chemokine signaling pathway_Homo sapiens_hsa040620.93703035
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.93115828
51Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.92269222
52Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90083813
53Jak-STAT signaling pathway_Homo sapiens_hsa046300.89951845
54Primary immunodeficiency_Homo sapiens_hsa053400.85433486
55Prion diseases_Homo sapiens_hsa050200.85374120
56Viral myocarditis_Homo sapiens_hsa054160.81615129
57Hepatitis B_Homo sapiens_hsa051610.80492984
58Vibrio cholerae infection_Homo sapiens_hsa051100.77813690
59Hepatitis C_Homo sapiens_hsa051600.76965262
60Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75668012
61Leukocyte transendothelial migration_Homo sapiens_hsa046700.74935930
62Amoebiasis_Homo sapiens_hsa051460.73976990
63Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.71706673
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.69487501
65Autoimmune thyroid disease_Homo sapiens_hsa053200.68291218
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68139089
67Pentose phosphate pathway_Homo sapiens_hsa000300.66384614
68Renin-angiotensin system_Homo sapiens_hsa046140.65627823
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65595811
70Histidine metabolism_Homo sapiens_hsa003400.63028734
71Proteasome_Homo sapiens_hsa030500.62302130
72Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.60585207
73Fructose and mannose metabolism_Homo sapiens_hsa000510.59636563
74Sphingolipid signaling pathway_Homo sapiens_hsa040710.59619775
75VEGF signaling pathway_Homo sapiens_hsa043700.59578096
76Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.59466536
77Peroxisome_Homo sapiens_hsa041460.58829775
78PPAR signaling pathway_Homo sapiens_hsa033200.57773378
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.57759045
80Folate biosynthesis_Homo sapiens_hsa007900.57722642
81Arginine biosynthesis_Homo sapiens_hsa002200.56468140
82Steroid biosynthesis_Homo sapiens_hsa001000.56044977
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.54048565
84Starch and sucrose metabolism_Homo sapiens_hsa005000.51874558
85Prolactin signaling pathway_Homo sapiens_hsa049170.51729613
86Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51492706
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.50487457
88Galactose metabolism_Homo sapiens_hsa000520.50013473
89Sulfur metabolism_Homo sapiens_hsa009200.46679267
90Acute myeloid leukemia_Homo sapiens_hsa052210.46641973
91Endocytosis_Homo sapiens_hsa041440.46270269
92Collecting duct acid secretion_Homo sapiens_hsa049660.41034559
93Epstein-Barr virus infection_Homo sapiens_hsa051690.40096744
94Tryptophan metabolism_Homo sapiens_hsa003800.40038991
95Chronic myeloid leukemia_Homo sapiens_hsa052200.39574828
96ABC transporters_Homo sapiens_hsa020100.39368507
97Renal cell carcinoma_Homo sapiens_hsa052110.37827042
98HTLV-I infection_Homo sapiens_hsa051660.36721672
99Mineral absorption_Homo sapiens_hsa049780.36675431
100Notch signaling pathway_Homo sapiens_hsa043300.36593665
101Fatty acid degradation_Homo sapiens_hsa000710.34897727
102Pancreatic cancer_Homo sapiens_hsa052120.34733497
103Platelet activation_Homo sapiens_hsa046110.34465250
104Vitamin digestion and absorption_Homo sapiens_hsa049770.33502921
105Nitrogen metabolism_Homo sapiens_hsa009100.32014883
106SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31491174
107GnRH signaling pathway_Homo sapiens_hsa049120.30770477
108HIF-1 signaling pathway_Homo sapiens_hsa040660.28978813
109Sphingolipid metabolism_Homo sapiens_hsa006000.28969114
110Chemical carcinogenesis_Homo sapiens_hsa052040.28064117
111Phospholipase D signaling pathway_Homo sapiens_hsa040720.27491404
112beta-Alanine metabolism_Homo sapiens_hsa004100.26947912
113Insulin resistance_Homo sapiens_hsa049310.26426747
114T cell receptor signaling pathway_Homo sapiens_hsa046600.26351055
115Neurotrophin signaling pathway_Homo sapiens_hsa047220.25012086
116Viral carcinogenesis_Homo sapiens_hsa052030.24464968
117Type II diabetes mellitus_Homo sapiens_hsa049300.24184176
118Systemic lupus erythematosus_Homo sapiens_hsa053220.23972637
119Selenocompound metabolism_Homo sapiens_hsa004500.22820363
120Proteoglycans in cancer_Homo sapiens_hsa052050.22103615
121Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19576328
122Non-small cell lung cancer_Homo sapiens_hsa052230.14903356

Most similar genes based on co-expression Upload to Enrichr

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