CTTN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1chondrocyte proliferation (GO:0035988)4.44234748
2regulation of integrin-mediated signaling pathway (GO:2001044)4.03779590
3epithelial cell-cell adhesion (GO:0090136)3.94224202
4hippo signaling (GO:0035329)3.91086823
5collagen fibril organization (GO:0030199)3.85529133
6polarized epithelial cell differentiation (GO:0030859)3.78946625
7paraxial mesoderm development (GO:0048339)3.74774980
8plasma membrane repair (GO:0001778)3.67214834
9COPI coating of Golgi vesicle (GO:0048205)3.64971864
10Golgi transport vesicle coating (GO:0048200)3.64971864
11hemidesmosome assembly (GO:0031581)3.62157031
12axon extension involved in axon guidance (GO:0048846)3.61706382
13neuron projection extension involved in neuron projection guidance (GO:1902284)3.61706382
14cell adhesion mediated by integrin (GO:0033627)3.55981458
15protein heterotrimerization (GO:0070208)3.54207768
16regulation of hippo signaling (GO:0035330)3.51200670
17positive regulation of protein autophosphorylation (GO:0031954)3.46564030
18endodermal cell differentiation (GO:0035987)3.43086542
19regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.42934517
20cytoskeletal anchoring at plasma membrane (GO:0007016)3.34308668
21proteasome assembly (GO:0043248)3.32711166
22lung-associated mesenchyme development (GO:0060484)3.32056707
23negative regulation of fatty acid transport (GO:2000192)3.30053585
24endocardial cushion development (GO:0003197)3.29296269
25regulation of calcineurin-NFAT signaling cascade (GO:0070884)3.18916058
26skin morphogenesis (GO:0043589)3.17424373
27regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.17033458
28lactate metabolic process (GO:0006089)3.15010569
29establishment of apical/basal cell polarity (GO:0035089)3.08974297
30regulation of tight junction assembly (GO:2000810)3.05876651
31peptidyl-proline hydroxylation (GO:0019511)3.02465275
32fibroblast migration (GO:0010761)3.01027331
33negative regulation of chondrocyte differentiation (GO:0032331)3.00714792
34planar cell polarity pathway involved in neural tube closure (GO:0090179)3.00425614
35negative regulation of catenin import into nucleus (GO:0035414)3.00208746
36basement membrane organization (GO:0071711)3.00092075
37positive regulation of actin filament depolymerization (GO:0030836)2.97592147
38UDP-N-acetylglucosamine metabolic process (GO:0006047)2.97248362
39protein maturation by protein folding (GO:0022417)2.95772626
40adherens junction assembly (GO:0034333)2.93192348
41positive regulation of endothelial cell apoptotic process (GO:2000353)2.91688678
42sequestering of extracellular ligand from receptor (GO:0035581)2.90186586
43protein hydroxylation (GO:0018126)2.89420774
44cell-substrate junction assembly (GO:0007044)2.86703801
45establishment or maintenance of monopolar cell polarity (GO:0061339)2.86320452
46establishment of monopolar cell polarity (GO:0061162)2.86320452
47anterior/posterior axis specification, embryo (GO:0008595)2.85587586
48regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81536306
49cell migration involved in sprouting angiogenesis (GO:0002042)2.78313929
50embryonic foregut morphogenesis (GO:0048617)2.77643999
51stress fiber assembly (GO:0043149)2.77579621
52maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.76426817
53bone trabecula formation (GO:0060346)2.72986874
54wound healing, spreading of epidermal cells (GO:0035313)2.72491169
55outer ear morphogenesis (GO:0042473)2.72193696
56protein localization to cell surface (GO:0034394)2.71692409
57regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.71097666
58positive regulation of glycoprotein metabolic process (GO:1903020)2.69080835
59protein retention in ER lumen (GO:0006621)2.65054645
60regulation of SMAD protein import into nucleus (GO:0060390)2.62195285
61gastrulation with mouth forming second (GO:0001702)2.59822046
62mesenchyme development (GO:0060485)2.59522837
63keratinocyte development (GO:0003334)2.59477870
64cellular response to vitamin (GO:0071295)2.59442775
65COPII vesicle coating (GO:0048208)2.57746048
66regulation of protein autophosphorylation (GO:0031952)2.56727310
67G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.54086669
68cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.53101609
69craniofacial suture morphogenesis (GO:0097094)2.52303275
70adherens junction organization (GO:0034332)2.52274989
71zinc ion transport (GO:0006829)2.52207226
72collagen metabolic process (GO:0032963)2.51745247
73positive regulation of glycoprotein biosynthetic process (GO:0010560)2.51537342
74regulation of cellular amino acid metabolic process (GO:0006521)2.51008990
75regulation of cardioblast differentiation (GO:0051890)2.50356904
76extracellular matrix disassembly (GO:0022617)2.49708205
77cellular response to vitamin D (GO:0071305)2.49441003
78negative regulation of keratinocyte proliferation (GO:0010839)2.49286275
79establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.48280985
80nucleotide-sugar biosynthetic process (GO:0009226)2.48011535
81notochord development (GO:0030903)2.47638125
82mesodermal cell differentiation (GO:0048333)2.47264935
83regulation of metalloenzyme activity (GO:0048552)2.46542414
84negative regulation of cartilage development (GO:0061037)2.46106780
85regulation of cell fate specification (GO:0042659)2.46044729
86multicellular organismal macromolecule metabolic process (GO:0044259)2.45574659
87renal filtration (GO:0097205)2.44821442
88apoptotic cell clearance (GO:0043277)2.44575767
89branching involved in salivary gland morphogenesis (GO:0060445)2.41761003
90endothelial cell morphogenesis (GO:0001886)2.41715991
91desmosome organization (GO:0002934)2.41485264
92regulation of early endosome to late endosome transport (GO:2000641)2.41236512
93collagen catabolic process (GO:0030574)2.41220549
94insulin-like growth factor receptor signaling pathway (GO:0048009)2.40277889
95regulation of gastrulation (GO:0010470)2.39242086
96establishment of nucleus localization (GO:0040023)2.38937050
97positive regulation of fibroblast migration (GO:0010763)2.37772702
98dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.36780837
99endosome to melanosome transport (GO:0035646)2.36555652
100endosome to pigment granule transport (GO:0043485)2.36555652
101organ induction (GO:0001759)2.35657615
102negative regulation of smooth muscle cell migration (GO:0014912)2.35596129
103actin filament depolymerization (GO:0030042)2.35528205
104membrane budding (GO:0006900)2.35434400
105substrate adhesion-dependent cell spreading (GO:0034446)2.35146127
106mesenchymal-epithelial cell signaling (GO:0060638)2.35091134
107ventricular cardiac muscle cell development (GO:0055015)2.34761472
108transcytosis (GO:0045056)2.33813139
109multicellular organismal metabolic process (GO:0044236)2.33427198
110metanephric mesenchyme development (GO:0072075)2.32933403
111positive regulation of SMAD protein import into nucleus (GO:0060391)2.32829564
112multicellular organismal catabolic process (GO:0044243)2.31918174
113melanin biosynthetic process (GO:0042438)2.31906781
114dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.31554469
115negative regulation of axon extension involved in axon guidance (GO:0048843)2.31084644
116Leydig cell differentiation (GO:0033327)2.31080734
117blood vessel endothelial cell migration (GO:0043534)2.30683156
118embryonic cranial skeleton morphogenesis (GO:0048701)2.30677688
119cullin deneddylation (GO:0010388)2.30132624
120regulation of catenin import into nucleus (GO:0035412)2.29582831
121cell-cell junction maintenance (GO:0045217)2.29368639
122positive regulation of epithelial to mesenchymal transition (GO:0010718)2.29041891
123regulation of transforming growth factor beta2 production (GO:0032909)2.28771742
124labyrinthine layer blood vessel development (GO:0060716)2.27930948
125glial cell proliferation (GO:0014009)2.27866338
126glomerular basement membrane development (GO:0032836)2.27809341
127bundle of His cell to Purkinje myocyte communication (GO:0086069)2.27644975
128cell-substrate adherens junction assembly (GO:0007045)2.27459302
129focal adhesion assembly (GO:0048041)2.27459302
130collecting duct development (GO:0072044)2.27140201
131platelet dense granule organization (GO:0060155)2.26788979
132response to redox state (GO:0051775)2.26506765
133positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.24958843
134negative regulation of axon guidance (GO:1902668)2.24911125
135regulation of keratinocyte proliferation (GO:0010837)2.23841716
136peptidyl-cysteine modification (GO:0018198)2.18599834
137DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.12573056
138protein deneddylation (GO:0000338)2.12399647
139positive regulation of protein targeting to membrane (GO:0090314)2.11538875
140negative regulation of protein autophosphorylation (GO:0031953)2.11509026
141signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.10462238
142intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.10462238
143negative regulation of stem cell proliferation (GO:2000647)2.09354240
144signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.08106015
145signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.08106015
146signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.08106015
147retina vasculature morphogenesis in camera-type eye (GO:0061299)2.07980276
148secondary metabolite biosynthetic process (GO:0044550)2.07311379
149tight junction assembly (GO:0070830)2.06204280
150fatty acid elongation (GO:0030497)2.06124099
151L-serine transport (GO:0015825)2.05555617
152type B pancreatic cell proliferation (GO:0044342)2.04246231
153positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.02277011
154female gonad development (GO:0008585)2.00425249
155protein heterotetramerization (GO:0051290)2.00218151
156regulation of protein glycosylation (GO:0060049)2.00172241
157regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.00008927
158signal transduction involved in DNA damage checkpoint (GO:0072422)1.99933839
159signal transduction involved in DNA integrity checkpoint (GO:0072401)1.99933839
160intestinal epithelial cell development (GO:0060576)1.99903671
161negative regulation of protein localization to cell surface (GO:2000009)1.98707654
162protein K6-linked ubiquitination (GO:0085020)1.98020959
163response to pheromone (GO:0019236)1.97814286
164signal transduction involved in cell cycle checkpoint (GO:0072395)1.96890132
165lipid particle organization (GO:0034389)1.94969057
166lipopolysaccharide biosynthetic process (GO:0009103)1.93360224
167regulation of protein localization to cell surface (GO:2000008)1.93309729
168cell-cell junction assembly (GO:0007043)1.93304844
169blastocyst development (GO:0001824)1.93043478
170glutathione derivative metabolic process (GO:1901685)1.89940868
171glutathione derivative biosynthetic process (GO:1901687)1.89940868
172negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)1.89413241

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human6.21209122
2TRIM28_21343339_ChIP-Seq_HEK293_Human4.53706149
3* RARG_19884340_ChIP-ChIP_MEFs_Mouse3.61457622
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98470057
5CLOCK_20551151_ChIP-Seq_293T_Human2.90416458
6NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.60150400
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.39942368
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37504386
9ESR1_15608294_ChIP-ChIP_MCF-7_Human2.24571835
10NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.13759804
11ZNF263_19887448_ChIP-Seq_K562_Human2.11961560
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.11938145
13HIF1A_21447827_ChIP-Seq_MCF-7_Human2.02979311
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.00885372
15TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.00827267
16SMAD_19615063_ChIP-ChIP_OVARY_Human1.99664459
17ESR1_21235772_ChIP-Seq_MCF-7_Human1.98339123
18PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.97494627
19GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.96290674
20WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.95545308
21RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.88090562
22SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86592419
23POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.81590726
24ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.73611774
25ATF3_27146783_Chip-Seq_COLON_Human1.71170019
26SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.67201713
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.66157042
28SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.64565627
29CDX2_19796622_ChIP-Seq_MESCs_Mouse1.63854291
30SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62874831
31PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.61353404
32AHR_22903824_ChIP-Seq_MCF-7_Human1.60682669
33TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.58402174
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.57950250
35RBPJ_22232070_ChIP-Seq_NCS_Mouse1.57326629
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.56052033
37ELK1_19687146_ChIP-ChIP_HELA_Human1.55110744
38TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.54900983
39P300_27058665_Chip-Seq_ZR-75-30cells_Human1.51804362
40KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51146096
41TCF3_18692474_ChIP-Seq_MEFs_Mouse1.49531064
42TP53_20018659_ChIP-ChIP_R1E_Mouse1.49164275
43FOXM1_26456572_ChIP-Seq_MCF-7_Human1.47172027
44EP300_21415370_ChIP-Seq_HL-1_Mouse1.45231847
45EGR1_19374776_ChIP-ChIP_THP-1_Human1.45116370
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.44125727
47* RACK7_27058665_Chip-Seq_MCF-7_Human1.43556567
48AR_21909140_ChIP-Seq_LNCAP_Human1.43510776
49AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.41856085
50EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41739949
51PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.41351204
52SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.40166465
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.40166465
54GABP_17652178_ChIP-ChIP_JURKAT_Human1.39363643
55GATA3_24758297_ChIP-Seq_MCF-7_Human1.38318305
56ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38062610
57SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.37974522
58TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37184310
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.36992583
60CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.35421900
61ERG_21242973_ChIP-ChIP_JURKAT_Human1.34449068
62UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34264996
63GBX2_23144817_ChIP-Seq_PC3_Human1.33223859
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.32819974
65NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.31376742
66NRF2_20460467_ChIP-Seq_MEFs_Mouse1.31376742
67ARNT_22903824_ChIP-Seq_MCF-7_Human1.31332997
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.31189395
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30523643
70PIAS1_25552417_ChIP-Seq_VCAP_Human1.30470443
71CJUN_26792858_Chip-Seq_BT549_Human1.30356140
72BRD4_25478319_ChIP-Seq_HGPS_Human1.29834651
73WT1_19549856_ChIP-ChIP_CCG9911_Human1.27782459
74* ELK3_25401928_ChIP-Seq_HUVEC_Human1.26635302
75KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25890956
76EOMES_21245162_ChIP-Seq_HESCs_Human1.25742352
77* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.25729547
78ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.25270134
79GATA2_21666600_ChIP-Seq_HMVEC_Human1.24780385
80EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.24229383
81TP53_18474530_ChIP-ChIP_U2OS_Human1.24047018
82SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23021693
83DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.22008401
84PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21700343
85HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.19536284
86HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.19317830
87TP53_22127205_ChIP-Seq_IMR90_Human1.17025084
88NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.16842708
89* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.16835064
90GATA4_25053715_ChIP-Seq_YYC3_Human1.16151299
91SOX2_20726797_ChIP-Seq_SW620_Human1.15006055
92FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.14674855
93ISL1_27105846_Chip-Seq_CPCs_Mouse1.13669435
94KDM2B_26808549_Chip-Seq_K562_Human1.12697525
95PADI4_21655091_ChIP-ChIP_MCF-7_Human1.12056494
96ESR1_20079471_ChIP-ChIP_T-47D_Human1.11581574
97ZFP57_27257070_Chip-Seq_ESCs_Mouse1.11535978
98FUS_26573619_Chip-Seq_HEK293_Human1.10537630
99SOX17_20123909_ChIP-Seq_XEN_Mouse1.10493992
100CTNNB1_20460455_ChIP-Seq_HCT116_Human1.10274820
101FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09718264
102UBF1/2_26484160_Chip-Seq_HMECs_Human1.09515488
103FOXO3_23340844_ChIP-Seq_DLD1_Human1.08919440
104SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08633826
105ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.07917758
106* GATA6_25053715_ChIP-Seq_YYC3_Human1.07625980
107* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.07513616
108NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.07073113
109POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06900068
110ELF5_23300383_ChIP-Seq_T47D_Human1.06844375
111DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06640903
112KLF5_25053715_ChIP-Seq_YYC3_Human1.06484771
113RUNX1_27514584_Chip-Seq_MCF-7_Human1.05860685
114SRF_21415370_ChIP-Seq_HL-1_Mouse1.05775536
115ZNF217_24962896_ChIP-Seq_MCF-7_Human1.05611864
116TP53_23651856_ChIP-Seq_MEFs_Mouse1.04393957
117* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02982382
118RNF2_18974828_ChIP-Seq_MESCs_Mouse1.02971066
119EZH2_18974828_ChIP-Seq_MESCs_Mouse1.02971066
120CDX2_22108803_ChIP-Seq_LS180_Human1.01604870
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.00753289
122SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00524723
123CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.99786221
124NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.99224106
125MYCN_18555785_ChIP-Seq_MESCs_Mouse0.98690027
126TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97768148
127EED_16625203_ChIP-ChIP_MESCs_Mouse0.97599421
128SOX9_24532713_ChIP-Seq_HFSC_Mouse0.97198148
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.97085263
130CREB1_26743006_Chip-Seq_LNCaP_Human0.96112983
131EST1_17652178_ChIP-ChIP_JURKAT_Human0.95695897
132KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94891596
133KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94891596
134KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94891596
135RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94811726
136NANOG_16153702_ChIP-ChIP_HESCs_Human0.94517179
137TCF3_18692474_ChIP-Seq_MESCs_Mouse0.93968997
138CHD1_26751641_Chip-Seq_LNCaP_Human0.93329223
139* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92152857
140TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.91894552
141MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91431086
142SOX2_18692474_ChIP-Seq_MEFs_Mouse0.91399282
143CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.91339024
144* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90786906
145ZNF274_21170338_ChIP-Seq_K562_Hela0.90754251
146SMAD4_21799915_ChIP-Seq_A2780_Human0.90533684
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.90373103
148P300_19829295_ChIP-Seq_ESCs_Human0.90214591
149OCT4_18692474_ChIP-Seq_MEFs_Mouse0.89135251
150RING1B_27294783_Chip-Seq_NPCs_Mouse0.88685259
151* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.88370407
152JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.86849955
153OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85388356
154E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84509185
155ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.82210247
156DCP1A_22483619_ChIP-Seq_HELA_Human0.80340873
157TP63_23658742_ChIP-Seq_EP156T_Human0.79942368

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen4.51832111
2MP0003705_abnormal_hypodermis_morpholog4.09175867
3MP0005171_absent_coat_pigmentation4.06938442
4MP0000372_irregular_coat_pigmentation3.59342881
5MP0005275_abnormal_skin_tensile3.39904954
6MP0003950_abnormal_plasma_membrane3.14935893
7MP0004272_abnormal_basement_membrane3.05942225
8MP0005623_abnormal_meninges_morphology2.97721764
9MP0005408_hypopigmentation2.94402537
10MP0005503_abnormal_tendon_morphology2.78637736
11MP0000537_abnormal_urethra_morphology2.76752829
12MP0010030_abnormal_orbit_morphology2.56246901
13MP0010352_gastrointestinal_tract_polyps2.54872521
14MP0000015_abnormal_ear_pigmentation2.54029721
15MP0003136_yellow_coat_color2.44166871
16MP0010234_abnormal_vibrissa_follicle2.40180509
17MP0003283_abnormal_digestive_organ2.25447776
18MP0002938_white_spotting2.19466737
19MP0003566_abnormal_cell_adhesion2.09292176
20MP0005174_abnormal_tail_pigmentation2.09077866
21MP0009053_abnormal_anal_canal2.07492663
22MP0004381_abnormal_hair_follicle1.93636653
23MP0009384_cardiac_valve_regurgitation1.92863223
24MP0003279_aneurysm1.91280253
25MP0001958_emphysema1.82464615
26MP0000534_abnormal_ureter_morphology1.82440941
27MP0006054_spinal_hemorrhage1.79409388
28MP0003942_abnormal_urinary_system1.71387482
29MP0000569_abnormal_digit_pigmentation1.68581042
30MP0003385_abnormal_body_wall1.65321848
31MP0001849_ear_inflammation1.57811390
32MP0003941_abnormal_skin_development1.56496792
33MP0003115_abnormal_respiratory_system1.54884952
34MP0005023_abnormal_wound_healing1.50513298
35MP0005508_abnormal_skeleton_morphology1.49271303
36MP0003091_abnormal_cell_migration1.47814874
37MP0001299_abnormal_eye_distance/1.47364435
38MP0003119_abnormal_digestive_system1.44755670
39MP0002896_abnormal_bone_mineralization1.43433201
40MP0004858_abnormal_nervous_system1.40106810
41MP0000013_abnormal_adipose_tissue1.38976673
42MP0002254_reproductive_system_inflammat1.37711426
43MP0009250_abnormal_appendicular_skeleto1.37634687
44MP0003123_paternal_imprinting1.34664992
45MP0000733_abnormal_muscle_development1.34263768
46MP0009780_abnormal_chondrocyte_physiolo1.32844180
47MP0004233_abnormal_muscle_weight1.31648775
48MP0005257_abnormal_intraocular_pressure1.31524599
49MP0002060_abnormal_skin_morphology1.30843659
50MP0002282_abnormal_trachea_morphology1.27881938
51MP0000428_abnormal_craniofacial_morphol1.26059252
52MP0003122_maternal_imprinting1.25632797
53MP0002234_abnormal_pharynx_morphology1.24407280
54MP0000427_abnormal_hair_cycle1.22944883
55MP0003755_abnormal_palate_morphology1.22218617
56MP0003937_abnormal_limbs/digits/tail_de1.21397747
57MP0000749_muscle_degeneration1.15963723
58MP0000371_diluted_coat_color1.15272528
59MP0002877_abnormal_melanocyte_morpholog1.15215132
60MP0004084_abnormal_cardiac_muscle1.14578089
61MP0002295_abnormal_pulmonary_circulatio1.12248141
62MP0005076_abnormal_cell_differentiation1.09595108
63MP0002932_abnormal_joint_morphology1.09298455
64MP0000751_myopathy1.08176497
65MP0000750_abnormal_muscle_regeneration1.07562024
66MP0000762_abnormal_tongue_morphology1.06157533
67MP0003718_maternal_effect1.05598070
68MP0005670_abnormal_white_adipose1.04780800
69MP0000462_abnormal_digestive_system1.04517177
70MP0005367_renal/urinary_system_phenotyp1.03591678
71MP0000516_abnormal_urinary_system1.03591678
72MP0000647_abnormal_sebaceous_gland1.03556648
73MP0002084_abnormal_developmental_patter1.03296958
74MP0003186_abnormal_redox_activity1.03234349
75MP0001542_abnormal_bone_strength1.02221967
76MP0002177_abnormal_outer_ear1.02021651
77MP0002089_abnormal_postnatal_growth/wei1.01671010
78MP0002653_abnormal_ependyma_morphology1.01226939
79MP0000538_abnormal_urinary_bladder1.00888473
80MP0003935_abnormal_craniofacial_develop1.00838797
81MP0002111_abnormal_tail_morphology1.00328185
82MP0005187_abnormal_penis_morphology1.00171711
83MP0004197_abnormal_fetal_growth/weight/0.99481487
84MP0002108_abnormal_muscle_morphology0.99071669
85MP0005248_abnormal_Harderian_gland0.98870420
86MP0000467_abnormal_esophagus_morphology0.98651292
87MP0002233_abnormal_nose_morphology0.98470678
88MP0004264_abnormal_extraembryonic_tissu0.96670587
89MP0000377_abnormal_hair_follicle0.95088377
90MP0000163_abnormal_cartilage_morphology0.94046434
91MP0002796_impaired_skin_barrier0.93797727
92MP0001348_abnormal_lacrimal_gland0.93079933
93MP0002697_abnormal_eye_size0.92787732
94MP0008932_abnormal_embryonic_tissue0.92685286
95MP0000049_abnormal_middle_ear0.89881281
96MP0005395_other_phenotype0.88810170
97MP0002085_abnormal_embryonic_tissue0.88467237
98MP0010368_abnormal_lymphatic_system0.87977978
99MP0002249_abnormal_larynx_morphology0.87824207
100MP0002090_abnormal_vision0.87793031
101MP0002116_abnormal_craniofacial_bone0.87336767
102MP0000432_abnormal_head_morphology0.86096110
103MP0001243_abnormal_dermal_layer0.84169305
104MP0000003_abnormal_adipose_tissue0.82622533
105MP0002102_abnormal_ear_morphology0.82485582
106MP0006138_congestive_heart_failure0.82261139
107MP0002168_other_aberrant_phenotype0.80780329
108MP0002095_abnormal_skin_pigmentation0.80116387
109MP0003195_calcinosis0.79433291
110MP0000613_abnormal_salivary_gland0.78551275
111MP0001661_extended_life_span0.77593019
112MP0002160_abnormal_reproductive_system0.77355793
113MP0001485_abnormal_pinna_reflex0.77251426
114MP0005501_abnormal_skin_physiology0.76623814
115MP0003786_premature_aging0.76401468
116MP0005197_abnormal_uvea_morphology0.76088675
117MP0003045_fibrosis0.75855400
118MP0010386_abnormal_urinary_bladder0.75700474
119MP0002909_abnormal_adrenal_gland0.75691831
120MP0004133_heterotaxia0.75684789
121MP0002086_abnormal_extraembryonic_tissu0.75361590
122MP0002115_abnormal_skeleton_extremities0.75218294
123MP0002088_abnormal_embryonic_growth/wei0.74662231
124* MP0001730_embryonic_growth_arrest0.74066616
125MP0003984_embryonic_growth_retardation0.73921327
126MP0002925_abnormal_cardiovascular_devel0.73744419
127MP0010678_abnormal_skin_adnexa0.73240193
128MP0005377_hearing/vestibular/ear_phenot0.72948280
129MP0003878_abnormal_ear_physiology0.72948280
130MP0009697_abnormal_copulation0.72688748
131MP0003567_abnormal_fetal_cardiomyocyte0.72659750
132MP0004087_abnormal_muscle_fiber0.72236886
133* MP0001672_abnormal_embryogenesis/_devel0.72209412
134* MP0005380_embryogenesis_phenotype0.72209412
135MP0008775_abnormal_heart_ventricle0.71786509
136MP0001697_abnormal_embryo_size0.70704445
137MP0002876_abnormal_thyroid_physiology0.69725808
138MP0002269_muscular_atrophy0.69208175
139MP0002114_abnormal_axial_skeleton0.68953048
140MP0000383_abnormal_hair_follicle0.68635803
141MP0010771_integument_phenotype0.68579750
142MP0000767_abnormal_smooth_muscle0.68067253
143MP0005075_abnormal_melanosome_morpholog0.63534963
144MP0001879_abnormal_lymphatic_vessel0.62820698
145MP0005165_increased_susceptibility_to0.61976621
146MP0001756_abnormal_urination0.61680411
147MP0002075_abnormal_coat/hair_pigmentati0.61070643
148MP0008007_abnormal_cellular_replicative0.60003071
149MP0002751_abnormal_autonomic_nervous0.60000672

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.65544216
2Premature rupture of membranes (HP:0001788)5.57290747
3Shallow orbits (HP:0000586)4.12259715
4Atrophic scars (HP:0001075)3.96219038
5White forelock (HP:0002211)3.85059201
6Patchy hypopigmentation of hair (HP:0011365)3.81712731
7Ankle contracture (HP:0006466)3.63637822
8Hypoplasia of the fovea (HP:0007750)3.61394180
9Aplasia/Hypoplasia of the fovea (HP:0008060)3.61394180
10Cerebral aneurysm (HP:0004944)3.27300239
11Albinism (HP:0001022)3.23996841
12Abnormality of dentin (HP:0010299)3.11104669
13Cutaneous melanoma (HP:0012056)3.09603502
14Aortic dissection (HP:0002647)3.07699305
15Cervical subluxation (HP:0003308)3.03046770
16Bladder diverticulum (HP:0000015)2.97586104
17Congenital sensorineural hearing impairment (HP:0008527)2.96681718
18Fragile skin (HP:0001030)2.95808132
19Broad metatarsal (HP:0001783)2.94478752
20Aplasia/Hypoplasia of the macula (HP:0008059)2.90830673
21Ependymoma (HP:0002888)2.88597070
22Abnormality of glycolysis (HP:0004366)2.88212430
23Bilateral sensorineural hearing impairment (HP:0008619)2.85905279
24Aortic aneurysm (HP:0004942)2.84726652
25Abnormality of the fovea (HP:0000493)2.83553382
26Wrist flexion contracture (HP:0001239)2.82245284
27Soft skin (HP:0000977)2.80486778
28Dilatation of the ascending aorta (HP:0005111)2.78438037
29Right ventricular cardiomyopathy (HP:0011663)2.75573584
30Aplasia/Hypoplasia affecting the retina (HP:0008061)2.69837058
31Neonatal short-limb short stature (HP:0008921)2.68303587
32Cardiovascular calcification (HP:0011915)2.67139063
33Increased connective tissue (HP:0009025)2.60938216
34Spinal rigidity (HP:0003306)2.54407668
35Genu recurvatum (HP:0002816)2.54298001
36Vascular calcification (HP:0004934)2.48449355
37Mildly elevated creatine phosphokinase (HP:0008180)2.44436365
38Difficulty climbing stairs (HP:0003551)2.43260693
39Delayed gross motor development (HP:0002194)2.41550603
40Peritonitis (HP:0002586)2.41461419
41Heterochromia iridis (HP:0001100)2.39916709
42Bowel diverticulosis (HP:0005222)2.38502297
43Popliteal pterygium (HP:0009756)2.38121790
44Hypoplasia of the iris (HP:0007676)2.35125407
45Hypokinesia (HP:0002375)2.34796291
46Generalized hypopigmentation (HP:0007513)2.34705806
47Short nail (HP:0001799)2.33384789
48Wormian bones (HP:0002645)2.32996110
49Upper limb amyotrophy (HP:0009129)2.32053897
50Distal upper limb amyotrophy (HP:0007149)2.32053897
51Hamartoma of the eye (HP:0010568)2.29776331
52Type 1 muscle fiber predominance (HP:0003803)2.28588664
53Mitral valve prolapse (HP:0001634)2.27391875
54Abnormality of the umbilical cord (HP:0010881)2.23417472
55Microglossia (HP:0000171)2.20508289
56Abnormal gallbladder physiology (HP:0012438)2.18925115
57Cholecystitis (HP:0001082)2.18925115
58Blue sclerae (HP:0000592)2.17784610
59Aneurysm (HP:0002617)2.15654235
60Increased serum pyruvate (HP:0003542)2.14721501
61Bronchomalacia (HP:0002780)2.12801086
62Hand muscle atrophy (HP:0009130)2.12747946
63Abnormalities of placenta or umbilical cord (HP:0001194)2.09923085
64Tongue fasciculations (HP:0001308)2.09896071
65Hyperextensible skin (HP:0000974)2.09567040
66Adrenal hypoplasia (HP:0000835)2.07591161
67Buphthalmos (HP:0000557)2.05818699
68Posterior subcapsular cataract (HP:0007787)2.04841317
69Vascular tortuosity (HP:0004948)2.04774629
70Deviation of the hallux (HP:0010051)2.01797746
71Abnormality of the calcaneus (HP:0008364)1.99167660
72Upper limb muscle weakness (HP:0003484)1.98737371
73Osteolytic defects of the phalanges of the hand (HP:0009771)1.98566079
74Osteolytic defects of the hand bones (HP:0009699)1.98566079
75Reduced subcutaneous adipose tissue (HP:0003758)1.97665430
76Coronal craniosynostosis (HP:0004440)1.94334369
77Thin bony cortex (HP:0002753)1.92641295
78Breast carcinoma (HP:0003002)1.91438834
79Radial bowing (HP:0002986)1.91178180
80Scapular winging (HP:0003691)1.91033321
81Alopecia of scalp (HP:0002293)1.90918010
82Aplasia of the musculature (HP:0100854)1.90478859
83Overgrowth (HP:0001548)1.89526986
84Follicular hyperkeratosis (HP:0007502)1.89110785
85Pterygium (HP:0001059)1.88532643
86Hallux valgus (HP:0001822)1.88164446
87Increased mean platelet volume (HP:0011877)1.86799744
88Entropion (HP:0000621)1.86669609
89Renal duplication (HP:0000075)1.86417967
90Abnormality of the acetabulum (HP:0003170)1.83840165
91Turricephaly (HP:0000262)1.83261285
92Back pain (HP:0003418)1.82981726
93Increased variability in muscle fiber diameter (HP:0003557)1.82328222
94Ulnar bowing (HP:0003031)1.81225325
95Spinal cord compression (HP:0002176)1.81211056
96Arterial tortuosity (HP:0005116)1.80155630
97Mesomelia (HP:0003027)1.80089689
98Abnormality of methionine metabolism (HP:0010901)1.79082550
99Lymphangioma (HP:0100764)1.78658737
100Natal tooth (HP:0000695)1.78255176
101Wide anterior fontanel (HP:0000260)1.78137965
102Congenital glaucoma (HP:0001087)1.77416371
103Abnormal auditory evoked potentials (HP:0006958)1.77215239
104Sparse eyelashes (HP:0000653)1.76830166
105Abnormality of placental membranes (HP:0011409)1.76771157
106Amniotic constriction ring (HP:0009775)1.76771157
107Subacute progressive viral hepatitis (HP:0006572)1.75603260
108Intrahepatic cholestasis (HP:0001406)1.74548186
109Abnormality of the distal phalanges of the toes (HP:0010182)1.70826822
110Abnormal delivery (HP:0001787)1.70380056
111Broad long bones (HP:0005622)1.70140051
112Elbow flexion contracture (HP:0002987)1.69924564
113Biconcave vertebral bodies (HP:0004586)1.69240235
114Hypoplastic pelvis (HP:0008839)1.68864517
115Knee flexion contracture (HP:0006380)1.68767691
116Shoulder girdle muscle weakness (HP:0003547)1.67644350
117Vertebral compression fractures (HP:0002953)1.67160034
118Bowed forearm bones (HP:0003956)1.67132321
119Bowing of the arm (HP:0006488)1.67132321
120Bifid tongue (HP:0010297)1.66634309
121Hypoplasia of the odontoid process (HP:0003311)1.66522394
122Long toe (HP:0010511)1.64480938
123Tibial bowing (HP:0002982)1.64400835
124Joint laxity (HP:0001388)1.64165684
125Selective tooth agenesis (HP:0001592)1.63152508
126Abnormal umbilical cord blood vessels (HP:0011403)1.62750913
127Single umbilical artery (HP:0001195)1.62750913
128Abnormality of the fetal cardiovascular system (HP:0010948)1.62750913
129Aplasia/Hypoplasia of the scapulae (HP:0006713)1.62389077
130Hypoplastic scapulae (HP:0000882)1.62389077
131Glioma (HP:0009733)1.62350782
132Enlarged penis (HP:0000040)1.62198701
133Blue irides (HP:0000635)1.62039177
134Tarsal synostosis (HP:0008368)1.59746654
135Bell-shaped thorax (HP:0001591)1.59649258
136Limb-girdle muscle weakness (HP:0003325)1.59424427
137Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55614436
138Hepatoblastoma (HP:0002884)1.55309625
139Muscle fibrillation (HP:0010546)1.55201029
140Sensory axonal neuropathy (HP:0003390)1.55192301
141Short 4th metacarpal (HP:0010044)1.55080215
142Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.55080215
143Camptodactyly of toe (HP:0001836)1.54461950
144Osteopenia (HP:0000938)1.53750160
145Fused cervical vertebrae (HP:0002949)1.53427878
146Type I transferrin isoform profile (HP:0003642)1.52727213
147Concave nail (HP:0001598)1.52349416
148Diminished movement (HP:0002374)1.51831046
149Flat acetabular roof (HP:0003180)1.51060995
150Abnormality of skeletal muscle fiber size (HP:0012084)1.50787298
151Abnormality of the astrocytes (HP:0100707)1.50091506
152Astrocytoma (HP:0009592)1.50091506
153Focal segmental glomerulosclerosis (HP:0000097)1.50067612
154Advanced eruption of teeth (HP:0006288)1.49812892
155Trismus (HP:0000211)1.49557473
156Stridor (HP:0010307)1.49372951
157Short hallux (HP:0010109)1.48922933
158Stillbirth (HP:0003826)1.48694363
159Limb-girdle muscle atrophy (HP:0003797)1.48580977
160Pelvic girdle muscle weakness (HP:0003749)1.48420533
161Milia (HP:0001056)1.47887366
162Abnormality of the lower motor neuron (HP:0002366)1.47845366
163Broad phalanx (HP:0006009)1.47581651
164Muscle fiber splitting (HP:0003555)1.47547363
165Hydroxyprolinuria (HP:0003080)1.46943813
166Abnormality of proline metabolism (HP:0010907)1.46943813
167Osteoarthritis (HP:0002758)1.46925984
168Sparse lateral eyebrow (HP:0005338)1.46663854
169Abnormality of aspartate family amino acid metabolism (HP:0010899)1.46400696
170Hypopigmentation of the fundus (HP:0007894)1.45557941
171Abnormal protein N-linked glycosylation (HP:0012347)1.44581843
172Abnormal glycosylation (HP:0012345)1.44581843

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA24.36409239
2MST43.91980097
3DDR23.59124624
4TRIB33.37848295
5LATS23.26044843
6TRIM282.90778725
7PDGFRA2.83259810
8EIF2AK12.79806041
9LATS12.54302608
10EIF2AK32.51552986
11TTN2.40427404
12MAP3K122.35880654
13STK392.24405936
14PKN22.23946136
15EPHB22.18635290
16NEK12.05642541
17TESK11.94966531
18PBK1.89146757
19LIMK11.81611818
20BRSK21.78232824
21PAK41.71960593
22RIPK11.71491324
23MET1.60660307
24STK38L1.58118071
25PAK21.52480321
26PTK61.45838196
27* PTK21.41458729
28SIK31.36369407
29MAP3K91.31085727
30* FER1.30939362
31BMX1.30464597
32PRKD31.28673228
33BRSK11.28536904
34MUSK1.27202263
35WEE11.26492414
36LMTK21.25557666
37TNIK1.23133177
38OXSR11.22079273
39NTRK11.21687665
40TYRO31.21224956
41ERBB31.20016306
42FRK1.17012472
43KSR11.16891036
44SIK11.15928006
45KSR21.15663134
46MKNK21.12986524
47MKNK11.12301481
48INSRR1.11858667
49SCYL21.11026876
50MST1R1.09984377
51NUAK11.05122875
52VRK21.04444296
53LRRK21.02116652
54EEF2K1.01455530
55PAK61.00890024
56MAP3K20.99716276
57MTOR0.97394525
58RPS6KB20.95071414
59MAPKAPK50.93035134
60GSK3A0.92751186
61MARK30.92160472
62PDK30.88931821
63PDK40.88931821
64MINK10.87678807
65ROCK10.87236899
66BMPR1B0.86852412
67STK30.86527734
68ERN10.84092979
69ILK0.83186555
70GRK10.83065097
71PTK2B0.83034735
72RET0.82223862
73BCR0.81744203
74PRKCE0.78346580
75PHKG10.77610625
76PHKG20.77610625
77PDGFRB0.77320314
78PLK20.76788458
79WNK30.76190335
80* MAP2K10.74017463
81MAP2K20.72472713
82MAPKAPK30.71507966
83ICK0.71452016
84TESK20.70430214
85ERBB20.69387709
86MARK10.68919104
87CDC42BPA0.68431114
88CDK140.67919889
89MOS0.67878093
90TGFBR10.65986092
91* FGFR10.65802559
92MYLK0.64949480
93ROCK20.64657893
94TRPM70.64459860
95ERBB40.64054510
96ALK0.63466672
97NEK60.63260938
98MAP3K80.63162370
99PLK30.62594462
100FLT30.61786990
101DYRK1B0.60274081
102DAPK10.59730306
103STK380.59675669
104CDK150.59079353
105STK100.58702598
106CDK180.58655308
107FGFR20.57603828
108PLK10.57421580
109NTRK30.57193995
110CSNK1G10.56932874
111TSSK60.56892473
112MAP3K30.56532436
113TIE10.55060663
114AKT30.55059729
115CAMKK10.53633269
116PDK20.53525685
117ACVR1B0.53199846
118PIK3CA0.51657200
119BUB10.51133738
120* PAK30.50606352
121GRK50.49186086
122CDK11A0.48983101
123ABL20.48796075
124TTK0.48328659
125* PRKCI0.48173239
126MAP3K100.47368731
127CDK60.46908738
128TGFBR20.46746450
129CAMK2D0.46415256
130* PAK10.45853760
131AKT20.45660977
132DAPK30.45519779
133MAP4K20.45150493
134DMPK0.45004435
135CSNK1E0.44601909
136ARAF0.43437546
137WNK40.42984366
138PASK0.42530235
139ADRBK10.41890155
140CSNK1G30.41616936
141TAF10.41534310
142NME10.41059152
143CDK120.40435283
144PRKG20.38852773
145CSNK1G20.38371303
146MELK0.38314958
147AURKA0.38246104
148EPHA30.37026486
149FGFR40.36540585
150CSNK1A1L0.35826824
151PIM20.35723892
152PNCK0.34169814

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030503.26734744
2ECM-receptor interaction_Homo sapiens_hsa045123.11531919
3Hippo signaling pathway_Homo sapiens_hsa043902.56295310
4Bladder cancer_Homo sapiens_hsa052192.46053784
5Focal adhesion_Homo sapiens_hsa045102.41676383
6Protein export_Homo sapiens_hsa030602.37343477
7Vitamin B6 metabolism_Homo sapiens_hsa007502.33041921
8Adherens junction_Homo sapiens_hsa045202.27344401
9Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.19890113
10Fatty acid elongation_Homo sapiens_hsa000622.11417571
11* Proteoglycans in cancer_Homo sapiens_hsa052052.02350091
12* Tight junction_Homo sapiens_hsa045302.01828441
13Sulfur metabolism_Homo sapiens_hsa009201.97021486
14Basal cell carcinoma_Homo sapiens_hsa052171.91198116
15Steroid biosynthesis_Homo sapiens_hsa001001.88859523
16Hedgehog signaling pathway_Homo sapiens_hsa043401.86888298
17* Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.79375097
18Protein digestion and absorption_Homo sapiens_hsa049741.79018479
19Glutathione metabolism_Homo sapiens_hsa004801.70633878
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.67911859
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.59943092
22Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.59879269
23Small cell lung cancer_Homo sapiens_hsa052221.59177629
24Dilated cardiomyopathy_Homo sapiens_hsa054141.57638337
25Propanoate metabolism_Homo sapiens_hsa006401.56210871
26TGF-beta signaling pathway_Homo sapiens_hsa043501.55838916
27Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.53160964
28Amoebiasis_Homo sapiens_hsa051461.45457527
29Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.44731360
30Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43028722
31Axon guidance_Homo sapiens_hsa043601.39399249
32MicroRNAs in cancer_Homo sapiens_hsa052061.38903902
33Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36959665
34Non-homologous end-joining_Homo sapiens_hsa034501.36567013
35Endometrial cancer_Homo sapiens_hsa052131.30130716
36Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.29412389
37Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.27146313
38Gap junction_Homo sapiens_hsa045401.26405449
39Central carbon metabolism in cancer_Homo sapiens_hsa052301.26017573
40Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.23345695
41Sphingolipid metabolism_Homo sapiens_hsa006001.22448857
42Glioma_Homo sapiens_hsa052141.21710020
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.19148182
44One carbon pool by folate_Homo sapiens_hsa006701.18040992
45Melanogenesis_Homo sapiens_hsa049161.17494817
46Thyroid cancer_Homo sapiens_hsa052161.16780166
47Melanoma_Homo sapiens_hsa052181.16097247
48Vibrio cholerae infection_Homo sapiens_hsa051101.12884679
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.11245052
50Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.10805583
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10768973
52Wnt signaling pathway_Homo sapiens_hsa043101.10632215
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.10343209
54Cyanoamino acid metabolism_Homo sapiens_hsa004601.08675678
55mTOR signaling pathway_Homo sapiens_hsa041501.08669489
56AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.05255628
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.04049230
58* Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.03922916
59Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02990913
60PI3K-Akt signaling pathway_Homo sapiens_hsa041511.02861743
61Folate biosynthesis_Homo sapiens_hsa007901.02489233
62p53 signaling pathway_Homo sapiens_hsa041151.02409595
63Regulation of actin cytoskeleton_Homo sapiens_hsa048101.00723265
64Chronic myeloid leukemia_Homo sapiens_hsa052200.98197302
65Estrogen signaling pathway_Homo sapiens_hsa049150.97503915
66Rap1 signaling pathway_Homo sapiens_hsa040150.94577367
67Oocyte meiosis_Homo sapiens_hsa041140.88597575
68Fatty acid metabolism_Homo sapiens_hsa012120.88315860
69Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87900050
70Renal cell carcinoma_Homo sapiens_hsa052110.87842005
71Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87715310
72Thyroid hormone synthesis_Homo sapiens_hsa049180.87112271
73Pentose phosphate pathway_Homo sapiens_hsa000300.86152675
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86033597
75Colorectal cancer_Homo sapiens_hsa052100.85982790
76Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.84453065
77Pathways in cancer_Homo sapiens_hsa052000.83607003
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83045387
79Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.82946989
80beta-Alanine metabolism_Homo sapiens_hsa004100.82847733
81Arginine and proline metabolism_Homo sapiens_hsa003300.82676529
82GnRH signaling pathway_Homo sapiens_hsa049120.82247382
83Biosynthesis of amino acids_Homo sapiens_hsa012300.81759679
84RNA polymerase_Homo sapiens_hsa030200.81496087
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.80495199
86ErbB signaling pathway_Homo sapiens_hsa040120.80104996
87Basal transcription factors_Homo sapiens_hsa030220.79788111
88Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.77839762
89Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77137592
90Chemical carcinogenesis_Homo sapiens_hsa052040.77014423
91Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76673650
92Mineral absorption_Homo sapiens_hsa049780.76554128
93VEGF signaling pathway_Homo sapiens_hsa043700.75649411
94Tyrosine metabolism_Homo sapiens_hsa003500.75436230
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74222334
96Mismatch repair_Homo sapiens_hsa034300.72315046
97Glycosaminoglycan degradation_Homo sapiens_hsa005310.72229507
98Carbon metabolism_Homo sapiens_hsa012000.71865465
99HIF-1 signaling pathway_Homo sapiens_hsa040660.71477814
100Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71373923
101Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71179144
102Leukocyte transendothelial migration_Homo sapiens_hsa046700.71054434
103Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.69499258
104AMPK signaling pathway_Homo sapiens_hsa041520.69456273
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69390029
106Butanoate metabolism_Homo sapiens_hsa006500.68676198
107Insulin signaling pathway_Homo sapiens_hsa049100.67878818
108Fat digestion and absorption_Homo sapiens_hsa049750.67340748
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.66393772
110Synaptic vesicle cycle_Homo sapiens_hsa047210.65729700
111RNA transport_Homo sapiens_hsa030130.64961042
112Prostate cancer_Homo sapiens_hsa052150.64884088
113Bile secretion_Homo sapiens_hsa049760.62721612
114Primary bile acid biosynthesis_Homo sapiens_hsa001200.62341968
115Metabolic pathways_Homo sapiens_hsa011000.61797093
116Fatty acid degradation_Homo sapiens_hsa000710.60524936
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60519891
118Maturity onset diabetes of the young_Homo sapiens_hsa049500.60167156
119Gastric acid secretion_Homo sapiens_hsa049710.60161837
120Pyrimidine metabolism_Homo sapiens_hsa002400.59942653
121Starch and sucrose metabolism_Homo sapiens_hsa005000.58616254
122Endocytosis_Homo sapiens_hsa041440.57793673
123Lysine degradation_Homo sapiens_hsa003100.57272097
124Cell cycle_Homo sapiens_hsa041100.56766770
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56346888
126Collecting duct acid secretion_Homo sapiens_hsa049660.56046234
127Glucagon signaling pathway_Homo sapiens_hsa049220.55911105
128Oxytocin signaling pathway_Homo sapiens_hsa049210.55705382
129Pancreatic cancer_Homo sapiens_hsa052120.53173545
130Nucleotide excision repair_Homo sapiens_hsa034200.52207059
131Renin-angiotensin system_Homo sapiens_hsa046140.52139900
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51562936
133Peroxisome_Homo sapiens_hsa041460.51094605
134Fructose and mannose metabolism_Homo sapiens_hsa000510.50193807
135Neurotrophin signaling pathway_Homo sapiens_hsa047220.49572453
136Galactose metabolism_Homo sapiens_hsa000520.48794041
137SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48338290
138N-Glycan biosynthesis_Homo sapiens_hsa005100.47041517
139Vascular smooth muscle contraction_Homo sapiens_hsa042700.46573370
140Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.46238474
141Nitrogen metabolism_Homo sapiens_hsa009100.46229054
142Retinol metabolism_Homo sapiens_hsa008300.45271575
143Circadian rhythm_Homo sapiens_hsa047100.43416685
144Prion diseases_Homo sapiens_hsa050200.43205823
145Pyruvate metabolism_Homo sapiens_hsa006200.42705163
146Fanconi anemia pathway_Homo sapiens_hsa034600.42580119
147Homologous recombination_Homo sapiens_hsa034400.42146797
148Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.41030148
149Non-small cell lung cancer_Homo sapiens_hsa052230.40973204
150Viral myocarditis_Homo sapiens_hsa054160.40955340
151cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40430705
152HTLV-I infection_Homo sapiens_hsa051660.37538982
153Dopaminergic synapse_Homo sapiens_hsa047280.36544494
154Aldosterone synthesis and secretion_Homo sapiens_hsa049250.35433965
155Selenocompound metabolism_Homo sapiens_hsa004500.35031323
156Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.34918959

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