CTTNBP2NL

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1microglial cell activation (GO:0001774)4.87557205
2positive regulation by symbiont of host defense response (GO:0052509)4.35153921
3modulation by symbiont of host defense response (GO:0052031)4.35153921
4modulation by organism of immune response of other organism involved in symbiotic interaction (GO:004.35153921
5modulation by organism of defense response of other organism involved in symbiotic interaction (GO:04.35153921
6positive regulation by organism of defense response of other organism involved in symbiotic interact4.35153921
7modulation by symbiont of host immune response (GO:0052553)4.35153921
8regulation of interferon-beta biosynthetic process (GO:0045357)4.33247921
9macrophage activation involved in immune response (GO:0002281)3.87407957
10cell adhesion mediated by integrin (GO:0033627)3.84037965
11pyrimidine nucleobase catabolic process (GO:0006208)3.48325530
12positive regulation of chemokine secretion (GO:0090197)3.13834826
13neuron projection extension involved in neuron projection guidance (GO:1902284)3.06508931
14axon extension involved in axon guidance (GO:0048846)3.06508931
15negative chemotaxis (GO:0050919)3.04608941
16substrate-dependent cell migration (GO:0006929)3.01975613
17I-kappaB phosphorylation (GO:0007252)2.99104009
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.96535104
19germ cell migration (GO:0008354)2.96311937
20regulation of macrophage chemotaxis (GO:0010758)2.93933346
21semaphorin-plexin signaling pathway (GO:0071526)2.91636782
22regulation of axon guidance (GO:1902667)2.91427643
23paraxial mesoderm development (GO:0048339)2.89904604
24macrophage activation (GO:0042116)2.89213455
25positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.88321176
26negative regulation of keratinocyte proliferation (GO:0010839)2.85829948
27negative regulation of granulocyte differentiation (GO:0030853)2.85199451
28regulation of axon extension involved in axon guidance (GO:0048841)2.84476657
29axonal fasciculation (GO:0007413)2.83829604
30apoptotic cell clearance (GO:0043277)2.81949633
31presynaptic membrane assembly (GO:0097105)2.80675416
32G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.80640803
33regulation of mononuclear cell migration (GO:0071675)2.80569832
34pathway-restricted SMAD protein phosphorylation (GO:0060389)2.78915007
35limb bud formation (GO:0060174)2.78653491
36lymphangiogenesis (GO:0001946)2.77168921
37dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.76677691
38cell migration involved in sprouting angiogenesis (GO:0002042)2.76040129
39nucleobase catabolic process (GO:0046113)2.75334856
40calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.74487938
41neuron recognition (GO:0008038)2.74125920
42establishment of tissue polarity (GO:0007164)2.74090020
43establishment of planar polarity (GO:0001736)2.74090020
44wound healing, spreading of epidermal cells (GO:0035313)2.73012990
45apical protein localization (GO:0045176)2.71477257
46neuron projection extension (GO:1990138)2.68193889
47negative regulation of smooth muscle cell migration (GO:0014912)2.67804865
48response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.67287720
49response to host (GO:0075136)2.67287720
50response to host defenses (GO:0052200)2.67287720
51hippo signaling (GO:0035329)2.67272478
52positive regulation of interferon-alpha production (GO:0032727)2.67060426
53basement membrane organization (GO:0071711)2.66842062
54regulation of SMAD protein import into nucleus (GO:0060390)2.66825842
55platelet-derived growth factor receptor signaling pathway (GO:0048008)2.66770680
56regulation of chemokine-mediated signaling pathway (GO:0070099)2.63761861
57response to host immune response (GO:0052572)2.60965196
58response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.60965196
59substrate adhesion-dependent cell spreading (GO:0034446)2.60315185
60regulation of chemokine secretion (GO:0090196)2.58548165
61inner ear receptor cell development (GO:0060119)2.57474125
62collagen fibril organization (GO:0030199)2.57299679
63stress fiber assembly (GO:0043149)2.56738131
64hyaluronan catabolic process (GO:0030214)2.55349825
65vascular endothelial growth factor signaling pathway (GO:0038084)2.55074673
66ruffle organization (GO:0031529)2.55060041
67retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54908292
68presynaptic membrane organization (GO:0097090)2.54442823
69positive regulation of SMAD protein import into nucleus (GO:0060391)2.54440155
70chondrocyte proliferation (GO:0035988)2.52905218
71regulation of interferon-alpha production (GO:0032647)2.50849460
72artery development (GO:0060840)2.48655607
73growth hormone receptor signaling pathway (GO:0060396)2.46601936
74ganglion development (GO:0061548)2.45840308
75lymph vessel development (GO:0001945)2.45760527
76neural crest cell development (GO:0014032)2.44958059
77central nervous system projection neuron axonogenesis (GO:0021952)2.44568351
78protein localization to endosome (GO:0036010)2.44444982
79keratan sulfate catabolic process (GO:0042340)2.43155992
80glial cell migration (GO:0008347)2.42028943
81lateral sprouting from an epithelium (GO:0060601)2.39908828
82negative regulation of protein localization to cell surface (GO:2000009)2.39504242
83retinal ganglion cell axon guidance (GO:0031290)2.38929948
84neuron remodeling (GO:0016322)2.36395675
85keratinization (GO:0031424)2.34320039
86regulation of hippo signaling (GO:0035330)2.34061694
87wound healing, spreading of cells (GO:0044319)2.33052945
88mesodermal cell differentiation (GO:0048333)2.32700134
89positive regulation of pathway-restricted SMAD protein phosphorylation (GO:0010862)2.32106696
90sequestering of extracellular ligand from receptor (GO:0035581)2.31937328
91smooth muscle tissue development (GO:0048745)2.31526412
92regulation of keratinocyte proliferation (GO:0010837)2.31306763
93cortical actin cytoskeleton organization (GO:0030866)2.31106487
94regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.30978168
95cerebral cortex cell migration (GO:0021795)2.30834064
96membrane assembly (GO:0071709)2.29992364
97cell-cell junction maintenance (GO:0045217)2.29665124
98positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.29068135
99mesenchymal-epithelial cell signaling (GO:0060638)2.28568321
100vagina development (GO:0060068)2.28435779
101renal filtration (GO:0097205)2.25586964
102hemidesmosome assembly (GO:0031581)2.23351232
103positive regulation of macrophage cytokine production (GO:0060907)2.23222689
104positive regulation of gastrulation (GO:2000543)2.22699724
105fibroblast migration (GO:0010761)2.22684664
106regulation of macrophage cytokine production (GO:0010935)2.21990444
107vocalization behavior (GO:0071625)2.21984176
108facial nerve structural organization (GO:0021612)2.21713984
109cerebral cortex radially oriented cell migration (GO:0021799)2.21448027
110central nervous system neuron axonogenesis (GO:0021955)2.21161492
111asymmetric protein localization (GO:0008105)2.20695173
112protein heterotrimerization (GO:0070208)2.20669554
113lens morphogenesis in camera-type eye (GO:0002089)2.20248584
114chondroitin sulfate catabolic process (GO:0030207)2.19977079
115phagocytosis, engulfment (GO:0006911)2.19846485
116negative regulation of stem cell proliferation (GO:2000647)2.18866393
117positive regulation of synapse assembly (GO:0051965)2.18007101
118anterior/posterior axis specification, embryo (GO:0008595)2.17996165
119negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.17915684
120negative regulation of translation, ncRNA-mediated (GO:0040033)2.17915684
121regulation of translation, ncRNA-mediated (GO:0045974)2.17915684
122endodermal cell differentiation (GO:0035987)2.17520434
123homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.17135337
124kidney mesenchyme development (GO:0072074)2.16599611
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.15688167
126dendrite morphogenesis (GO:0048813)2.13957650
127metanephric mesenchyme development (GO:0072075)2.13462597
128response to fluid shear stress (GO:0034405)2.13450805
129axon extension (GO:0048675)2.12783959
130regulation of smooth muscle cell migration (GO:0014910)2.12719547
131positive regulation of smooth muscle cell migration (GO:0014911)2.12661450
132atrial cardiac muscle cell action potential (GO:0086014)2.11017640
133female genitalia development (GO:0030540)2.10349558
134endothelial cell morphogenesis (GO:0001886)2.10201168
135regulation of chondrocyte differentiation (GO:0032330)2.10051730
136cytoplasmic mRNA processing body assembly (GO:0033962)2.08676595
137developmental cell growth (GO:0048588)2.08672884
138positive regulation of cardiac muscle cell differentiation (GO:2000727)2.08584645
139nonmotile primary cilium assembly (GO:0035058)2.08554516
140regulation of transforming growth factor beta2 production (GO:0032909)2.08452916
141sympathetic nervous system development (GO:0048485)2.07146881
142regulation of glomerular filtration (GO:0003093)2.06344970
143regulation of synapse assembly (GO:0051963)2.05021230
144morphogenesis of an epithelial sheet (GO:0002011)2.04676704
145lung lobe morphogenesis (GO:0060463)2.04257766
146negative regulation of axon guidance (GO:1902668)2.03917257
147cortical cytoskeleton organization (GO:0030865)2.03789474
148glomerular filtration (GO:0003094)2.03627580
149cellular response to growth hormone stimulus (GO:0071378)2.03524295
150cell surface receptor signaling pathway involved in heart development (GO:0061311)2.03397185
151regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.03357410
152response to laminar fluid shear stress (GO:0034616)2.03302073
153artery morphogenesis (GO:0048844)2.02968268
154surfactant homeostasis (GO:0043129)2.02404559
155Notch signaling involved in heart development (GO:0061314)2.02071740
156cartilage morphogenesis (GO:0060536)2.01790285
157ephrin receptor signaling pathway (GO:0048013)2.01771318
158negative regulation of chondrocyte differentiation (GO:0032331)2.01542557
159monocyte differentiation (GO:0030224)2.01367111
160negative regulation of axon extension involved in axon guidance (GO:0048843)2.01306832
161regulation of integrin activation (GO:0033623)2.00935296
162cell junction maintenance (GO:0034331)2.00731333
163positive regulation of cartilage development (GO:0061036)1.99990956
164kidney morphogenesis (GO:0060993)1.99987467
165regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)1.99907580
166regulation of inhibitory postsynaptic membrane potential (GO:0060080)1.99233949
167olfactory bulb development (GO:0021772)1.99161263
168embryonic foregut morphogenesis (GO:0048617)1.98653745
169gap junction assembly (GO:0016264)1.98134329
170neuron cell-cell adhesion (GO:0007158)1.97808420
171appendage development (GO:0048736)1.97364447
172limb development (GO:0060173)1.97364447
173negative regulation of synaptic transmission, GABAergic (GO:0032229)1.96728053
174cell fate commitment involved in formation of primary germ layer (GO:0060795)1.96708477
175head development (GO:0060322)1.95949093
176glomerular visceral epithelial cell development (GO:0072015)1.95748987
177skin morphogenesis (GO:0043589)1.94986738

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human2.95606726
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.90318533
3BP1_19119308_ChIP-ChIP_Hs578T_Human2.81219356
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.80637447
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.69943997
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.69584874
7EZH2_22144423_ChIP-Seq_EOC_Human2.65728867
8ZFP57_27257070_Chip-Seq_ESCs_Mouse2.60960892
9SMAD_19615063_ChIP-ChIP_OVARY_Human2.51381954
10* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.27360768
11TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.13523651
12TAF15_26573619_Chip-Seq_HEK293_Human2.09991055
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.02540280
14PIAS1_25552417_ChIP-Seq_VCAP_Human2.00735158
15ZNF217_24962896_ChIP-Seq_MCF-7_Human1.98920165
16POU3F2_20337985_ChIP-ChIP_501MEL_Human1.98830428
17EGR1_19374776_ChIP-ChIP_THP-1_Human1.96049581
18FUS_26573619_Chip-Seq_HEK293_Human1.95353058
19* IRF8_27001747_Chip-Seq_BMDM_Mouse1.93840261
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.93501474
21P300_19829295_ChIP-Seq_ESCs_Human1.91814873
22STAT6_21828071_ChIP-Seq_BEAS2B_Human1.88694844
23ZNF274_21170338_ChIP-Seq_K562_Hela1.87659805
24SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84506635
25CJUN_26792858_Chip-Seq_BT549_Human1.83680198
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.81460873
27SMAD4_21799915_ChIP-Seq_A2780_Human1.80999723
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.78523686
29WT1_19549856_ChIP-ChIP_CCG9911_Human1.77437285
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.76790206
31STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.74661200
32* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.72746907
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72517966
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.72403498
35* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71340293
36VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.67896980
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.67713773
38ESR1_21235772_ChIP-Seq_MCF-7_Human1.66632626
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.65828150
40* EP300_21415370_ChIP-Seq_HL-1_Mouse1.64370388
41VDR_24787735_ChIP-Seq_THP-1_Human1.61440520
42GATA2_21666600_ChIP-Seq_HMVEC_Human1.61166643
43TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.58850469
44TP53_16413492_ChIP-PET_HCT116_Human1.58395024
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57989744
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.57490633
47EWS_26573619_Chip-Seq_HEK293_Human1.56995615
48MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.55969785
49SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.51443195
50FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.49913713
51AHR_22903824_ChIP-Seq_MCF-7_Human1.49159332
52SMAD3_21741376_ChIP-Seq_EPCs_Human1.49095852
53WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.48570994
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48451179
55CBX2_27304074_Chip-Seq_ESCs_Mouse1.47929849
56TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.47443617
57CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46572447
58* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45826139
59VDR_22108803_ChIP-Seq_LS180_Human1.45723745
60CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.44739802
61PPAR_26484153_Chip-Seq_NCI-H1993_Human1.42867561
62RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42384726
63SALL1_21062744_ChIP-ChIP_HESCs_Human1.41384479
64FOXO3_23340844_ChIP-Seq_DLD1_Human1.39798070
65PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.38905626
66BRD4_25478319_ChIP-Seq_HGPS_Human1.38699291
67NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.36535238
68SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.36341102
69* AR_25329375_ChIP-Seq_VCAP_Human1.33944394
70SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33629879
71ESR1_20079471_ChIP-ChIP_T-47D_Human1.33214401
72NR3C1_21868756_ChIP-Seq_MCF10A_Human1.31868917
73CLOCK_20551151_ChIP-Seq_293T_Human1.31738252
74EZH2_27304074_Chip-Seq_ESCs_Mouse1.31730273
75UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.31460047
76ARNT_22903824_ChIP-Seq_MCF-7_Human1.30727670
77* STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30331708
78STAT3_23295773_ChIP-Seq_U87_Human1.30140541
79IGF1R_20145208_ChIP-Seq_DFB_Human1.29432307
80KDM2B_26808549_Chip-Seq_SUP-B15_Human1.29125072
81* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.29043475
82KDM2B_26808549_Chip-Seq_K562_Human1.29006596
83SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.28632548
84SOX9_24532713_ChIP-Seq_HFSC_Mouse1.27125229
85BCAT_22108803_ChIP-Seq_LS180_Human1.26443235
86BMI1_23680149_ChIP-Seq_NPCS_Mouse1.25913367
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.25350384
88NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24684476
89* SALL4_18804426_ChIP-ChIP_XEN_Mouse1.24132448
90SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24062956
91POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23718457
92CBP_20019798_ChIP-Seq_JUKART_Human1.23668642
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23668642
94* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23261894
95WT1_25993318_ChIP-Seq_PODOCYTE_Human1.22757913
96FOXM1_26456572_ChIP-Seq_MCF-7_Human1.20584984
97SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20497493
98SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20497493
99TCF4_18268006_ChIP-ChIP_LS174T_Human1.20259940
100GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19448614
101* NANOG_18555785_Chip-Seq_ESCs_Mouse1.19419813
102NFIB_24661679_ChIP-Seq_LUNG_Mouse1.19040089
103RNF2_27304074_Chip-Seq_NSC_Mouse1.19010064
104RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.16886299
105TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.16009921
106EZH2_18974828_ChIP-Seq_MESCs_Mouse1.15823853
107RNF2_18974828_ChIP-Seq_MESCs_Mouse1.15823853
108KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.15573790
109* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15505033
110TP53_18474530_ChIP-ChIP_U2OS_Human1.14282605
111RUNX2_22187159_ChIP-Seq_PCA_Human1.13611118
112HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11691571
113* JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.11389453
114SPI1_23127762_ChIP-Seq_K562_Human1.10693165
115RBPJ_22232070_ChIP-Seq_NCS_Mouse1.10163771
116SMAD3_21741376_ChIP-Seq_HESCs_Human1.09889074
117* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.09812670
118NR3C1_23031785_ChIP-Seq_PC12_Mouse1.09573702
119* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08917787
120CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08897527
121TCF4_23295773_ChIP-Seq_U87_Human1.08688085
122NRF2_20460467_ChIP-Seq_MEFs_Mouse1.08443926
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.08443926
124TCF4_22108803_ChIP-Seq_LS180_Human1.08008698
125ELK3_25401928_ChIP-Seq_HUVEC_Human1.06849840
126TBX3_20139965_ChIP-Seq_ESCs_Mouse1.06847934
127TBX3_20139965_ChIP-Seq_MESCs_Mouse1.06836288
128* CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06348597
129FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.06149672
130PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.05948471
131NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.05539439
132SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.05492484
133YAP1_20516196_ChIP-Seq_MESCs_Mouse1.05359179
134SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04635070
135POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.04480491
136TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04480491
137* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.04040981
138RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.03998241
139SOX2_21211035_ChIP-Seq_LN229_Gbm1.03996978
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.03636038
141CDX2_22108803_ChIP-Seq_LS180_Human1.03567957
142* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.02910398
143JUN_21703547_ChIP-Seq_K562_Human1.02841890
144* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02713250
145RXR_22108803_ChIP-Seq_LS180_Human1.02702207
146AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.02554473
147* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01116030
148TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.00685069
149SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00523883
150SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.00523675
151ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00410247
152HIF1A_21447827_ChIP-Seq_MCF-7_Human1.00226973
153* SOX2_20726797_ChIP-Seq_SW620_Human1.00048153
154RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.99915396
155RNF2_27304074_Chip-Seq_ESCs_Mouse0.99341882
156SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.97833408
157FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97581324
158ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.97436218
159EED_16625203_ChIP-ChIP_MESCs_Mouse0.96713565
160RING1B_27294783_Chip-Seq_NPCs_Mouse0.96060820
161KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95858758
162KDM2B_26808549_Chip-Seq_JURKAT_Human0.95699058
163PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.93259633
164* SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.90463636
165KLF5_25053715_ChIP-Seq_YYC3_Human0.89758935
166KDM2B_26808549_Chip-Seq_DND41_Human0.89426260

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen2.97209283
2MP0010368_abnormal_lymphatic_system2.78830433
3MP0000569_abnormal_digit_pigmentation2.74762056
4MP0005623_abnormal_meninges_morphology2.65014417
5MP0004272_abnormal_basement_membrane2.62983733
6MP0003705_abnormal_hypodermis_morpholog2.48469686
7MP0003566_abnormal_cell_adhesion2.41272641
8MP0003950_abnormal_plasma_membrane2.34430695
9MP0003091_abnormal_cell_migration2.30358983
10MP0003303_peritoneal_inflammation2.26362202
11MP0005058_abnormal_lysosome_morphology2.16786431
12MP0005257_abnormal_intraocular_pressure2.16636379
13MP0000767_abnormal_smooth_muscle2.08843225
14MP0006082_CNS_inflammation2.06887948
15MP0003279_aneurysm2.04023334
16MP0001958_emphysema1.96910081
17MP0001879_abnormal_lymphatic_vessel1.95604576
18MP0002102_abnormal_ear_morphology1.94385628
19MP0000733_abnormal_muscle_development1.93149653
20MP0003172_abnormal_lysosome_physiology1.81461193
21MP0004510_myositis1.79449397
22MP0009053_abnormal_anal_canal1.79257866
23MP0003191_abnormal_cellular_cholesterol1.76684994
24MP0003385_abnormal_body_wall1.74009400
25MP0005187_abnormal_penis_morphology1.71379600
26MP0008789_abnormal_olfactory_epithelium1.70197847
27MP0003045_fibrosis1.69919016
28MP0003300_gastrointestinal_ulcer1.69458742
29MP0005076_abnormal_cell_differentiation1.65443854
30MP0003828_pulmonary_edema1.64204613
31MP0001915_intracranial_hemorrhage1.64055746
32MP0010386_abnormal_urinary_bladder1.63870113
33MP0000049_abnormal_middle_ear1.62534539
34MP0002233_abnormal_nose_morphology1.59959913
35MP0005167_abnormal_blood-brain_barrier1.59868283
36MP0006054_spinal_hemorrhage1.56408685
37MP0002234_abnormal_pharynx_morphology1.52201401
38MP0010030_abnormal_orbit_morphology1.51383526
39MP0005394_taste/olfaction_phenotype1.51179136
40MP0005499_abnormal_olfactory_system1.51179136
41MP0000537_abnormal_urethra_morphology1.50419080
42MP0001849_ear_inflammation1.44077193
43MP0009780_abnormal_chondrocyte_physiolo1.43936079
44MP0000762_abnormal_tongue_morphology1.43731663
45MP0005275_abnormal_skin_tensile1.42494122
46MP0010352_gastrointestinal_tract_polyps1.41575838
47MP0005197_abnormal_uvea_morphology1.40691529
48MP0002653_abnormal_ependyma_morphology1.40375270
49MP0002254_reproductive_system_inflammat1.38486092
50MP0005023_abnormal_wound_healing1.35594724
51MP0004883_abnormal_blood_vessel1.35097743
52MP0005508_abnormal_skeleton_morphology1.33506859
53MP0003890_abnormal_embryonic-extraembry1.32257571
54MP0003690_abnormal_glial_cell1.31616500
55MP0009384_cardiac_valve_regurgitation1.30935677
56MP0003880_abnormal_central_pattern1.29934204
57MP0001188_hyperpigmentation1.28442386
58MP0009278_abnormal_bone_marrow1.27737264
59MP0005248_abnormal_Harderian_gland1.27288342
60MP0002925_abnormal_cardiovascular_devel1.26028638
61MP0008004_abnormal_stomach_pH1.23592200
62MP0002998_abnormal_bone_remodeling1.21053005
63MP0006276_abnormal_autonomic_nervous1.20404084
64MP0003448_altered_tumor_morphology1.18993253
65MP0001851_eye_inflammation1.17161824
66MP0001346_abnormal_lacrimal_gland1.17027717
67MP0000343_altered_response_to1.16424542
68MP0005171_absent_coat_pigmentation1.16338233
69MP0002751_abnormal_autonomic_nervous1.15040589
70MP0000534_abnormal_ureter_morphology1.14992808
71MP0002295_abnormal_pulmonary_circulatio1.14778436
72MP0001614_abnormal_blood_vessel1.14255915
73MP0003119_abnormal_digestive_system1.11326286
74MP0005367_renal/urinary_system_phenotyp1.11034824
75MP0000516_abnormal_urinary_system1.11034824
76MP0001299_abnormal_eye_distance/1.10748914
77MP0004133_heterotaxia1.10619407
78MP0005595_abnormal_vascular_smooth1.10450792
79MP0006072_abnormal_retinal_apoptosis1.09767498
80MP0001542_abnormal_bone_strength1.09420883
81MP0002177_abnormal_outer_ear1.08472110
82MP0000647_abnormal_sebaceous_gland1.06967535
83MP0001533_abnormal_skeleton_physiology1.06164433
84MP0000579_abnormal_nail_morphology1.06075741
85MP0003453_abnormal_keratinocyte_physiol1.05490767
86MP0002282_abnormal_trachea_morphology1.04325322
87MP0005503_abnormal_tendon_morphology1.04322847
88MP0001984_abnormal_olfaction1.03760757
89MP0004859_abnormal_synaptic_plasticity1.02435369
90MP0002184_abnormal_innervation1.02249252
91MP0002796_impaired_skin_barrier1.01507517
92MP0000432_abnormal_head_morphology1.00968799
93MP0005390_skeleton_phenotype1.00748109
94MP0003937_abnormal_limbs/digits/tail_de0.99276548
95MP0004185_abnormal_adipocyte_glucose0.98424714
96MP0006138_congestive_heart_failure0.97937741
97MP0005164_abnormal_response_to0.97662994
98MP0000465_gastrointestinal_hemorrhage0.97422655
99MP0000778_abnormal_nervous_system0.97360590
100MP0001529_abnormal_vocalization0.96372017
101MP0003755_abnormal_palate_morphology0.96250985
102MP0004270_analgesia0.95897952
103MP0003718_maternal_effect0.95087893
104MP0003115_abnormal_respiratory_system0.95006199
105MP0002168_other_aberrant_phenotype0.94158887
106MP0004084_abnormal_cardiac_muscle0.94082709
107MP0001175_abnormal_lung_morphology0.93508631
108MP0003941_abnormal_skin_development0.93183652
109MP0002896_abnormal_bone_mineralization0.92358292
110MP0002938_white_spotting0.92201842
111MP0001286_abnormal_eye_development0.92170294
112MP0009250_abnormal_appendicular_skeleto0.92165371
113MP0010234_abnormal_vibrissa_follicle0.91784428
114MP0001293_anophthalmia0.91316171
115MP0003315_abnormal_perineum_morphology0.91303772
116MP0000566_synostosis0.91023428
117MP0003935_abnormal_craniofacial_develop0.90009767
118MP0002108_abnormal_muscle_morphology0.89608912
119MP0010678_abnormal_skin_adnexa0.88332333
120MP0000538_abnormal_urinary_bladder0.87515585
121MP0002128_abnormal_blood_circulation0.86985361
122MP0002419_abnormal_innate_immunity0.86778610
123MP0003861_abnormal_nervous_system0.85970978
124MP0000428_abnormal_craniofacial_morphol0.85958483
125MP0002928_abnormal_bile_duct0.85449395
126MP0002113_abnormal_skeleton_development0.82892167
127MP0001177_atelectasis0.82829098
128MP0003121_genomic_imprinting0.81278214
129MP0002697_abnormal_eye_size0.81153637
130MP0005253_abnormal_eye_physiology0.80581366
131MP0002109_abnormal_limb_morphology0.80403481
132MP0003075_altered_response_to0.79823985
133MP0000955_abnormal_spinal_cord0.79354554
134MP0002133_abnormal_respiratory_system0.79153414
135MP0005388_respiratory_system_phenotype0.79153414
136MP0002116_abnormal_craniofacial_bone0.78735330
137MP0005193_abnormal_anterior_eye0.78263649
138MP0000249_abnormal_blood_vessel0.78112726
139MP0004484_altered_response_of0.77706185
140MP0002084_abnormal_developmental_patter0.77087642
141MP0010630_abnormal_cardiac_muscle0.77077694
142MP0004858_abnormal_nervous_system0.77073494
143MP0005391_vision/eye_phenotype0.76521180
144MP0003942_abnormal_urinary_system0.76111910
145MP0003011_delayed_dark_adaptation0.75469227
146MP0002092_abnormal_eye_morphology0.75096907
147MP0000427_abnormal_hair_cycle0.74240324
148MP0009046_muscle_twitch0.73789474
149MP0005464_abnormal_platelet_physiology0.73556140
150MP0002115_abnormal_skeleton_extremities0.73361392
151MP0003122_maternal_imprinting0.73319353
152MP0000631_abnormal_neuroendocrine_gland0.72386379
153MP0002277_abnormal_respiratory_mucosa0.71587867
154MP0002081_perinatal_lethality0.71502322
155MP0005409_darkened_coat_color0.70523595
156MP0000383_abnormal_hair_follicle0.69738416

Predicted human phenotypes

RankGene SetZ-score
1Arterial tortuosity (HP:0005116)4.66035850
2Cerebral aneurysm (HP:0004944)4.47172316
3Vascular tortuosity (HP:0004948)4.44673022
4Systemic lupus erythematosus (HP:0002725)4.26166480
5Aortic aneurysm (HP:0004942)3.63958259
6Glomerulonephritis (HP:0000099)3.55702674
7Hematochezia (HP:0002573)3.48140865
8Abnormality of glycolipid metabolism (HP:0010969)3.40631650
9Abnormality of liposaccharide metabolism (HP:0010968)3.40631650
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.40631650
11Shallow orbits (HP:0000586)3.29580706
12Aortic dissection (HP:0002647)3.27625281
13Disinhibition (HP:0000734)3.04966473
14Premature rupture of membranes (HP:0001788)2.95554080
15Mutism (HP:0002300)2.93674129
16Increased cerebral lipofuscin (HP:0011813)2.93468530
17Urethral obstruction (HP:0000796)2.81327974
18Follicular hyperkeratosis (HP:0007502)2.65981861
19Disproportionate tall stature (HP:0001519)2.53468690
20Mitral valve prolapse (HP:0001634)2.47955147
21Wrist flexion contracture (HP:0001239)2.46891895
22Increased neuronal autofluorescent lipopigment (HP:0002074)2.41701725
23Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.38003599
24Nephritis (HP:0000123)2.32287613
25Neonatal short-limb short stature (HP:0008921)2.31298384
26Camptodactyly of toe (HP:0001836)2.30016062
27Protrusio acetabuli (HP:0003179)2.23586297
28Asymmetry of the thorax (HP:0001555)2.23454817
29Atrophic scars (HP:0001075)2.20310406
30Short 4th metacarpal (HP:0010044)2.19704689
31Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.19704689
32Abnormality of dentin (HP:0010299)2.15009845
33Spondylolisthesis (HP:0003302)2.13429328
34Cortical dysplasia (HP:0002539)2.13421206
35Drooling (HP:0002307)2.12483654
36Overgrowth (HP:0001548)2.10304673
37Osteolytic defects of the hand bones (HP:0009699)2.08644140
38Osteolytic defects of the phalanges of the hand (HP:0009771)2.08644140
39Morphological abnormality of the middle ear (HP:0008609)2.08166022
40Thick nail (HP:0001805)2.07920856
41Soft skin (HP:0000977)2.07812862
42Hyperventilation (HP:0002883)2.07753565
43Aneurysm (HP:0002617)2.03376804
44Striae distensae (HP:0001065)2.02181632
45Dysostosis multiplex (HP:0000943)2.02064583
46Complement deficiency (HP:0004431)2.00232948
47Ankle contracture (HP:0006466)1.99852609
48Subacute progressive viral hepatitis (HP:0006572)1.99354104
49Bladder diverticulum (HP:0000015)1.95747265
50Arnold-Chiari malformation (HP:0002308)1.94972186
51Absent speech (HP:0001344)1.93049958
52Retinal atrophy (HP:0001105)1.92514869
53Recurrent abscess formation (HP:0002722)1.92134811
54Scapular winging (HP:0003691)1.91657444
55Dilatation of the ascending aorta (HP:0005111)1.91117085
56Delayed gross motor development (HP:0002194)1.89334590
57Leiomyosarcoma (HP:0100243)1.86118169
58Uterine leiomyosarcoma (HP:0002891)1.86118169
59Apathy (HP:0000741)1.86115740
60Pulmonic stenosis (HP:0001642)1.85940538
61Hypoplastic labia majora (HP:0000059)1.85268198
62Flexion contracture of toe (HP:0005830)1.84818553
63Joint contractures involving the joints of the feet (HP:0100492)1.84818553
64Axonal loss (HP:0003447)1.84503509
65Inappropriate behavior (HP:0000719)1.82552976
66Limited hip movement (HP:0008800)1.81271750
67Transitional cell carcinoma of the bladder (HP:0006740)1.80508726
68Stenosis of the external auditory canal (HP:0000402)1.79414857
69Bifid tongue (HP:0010297)1.79407202
70Bladder neoplasm (HP:0009725)1.78918480
71Bladder carcinoma (HP:0002862)1.78918480
72Cervical subluxation (HP:0003308)1.77500522
73Genital tract atresia (HP:0001827)1.77298148
74Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.77066673
75Medial flaring of the eyebrow (HP:0010747)1.76951428
76Bicuspid aortic valve (HP:0001647)1.76618874
77Recurrent bacterial skin infections (HP:0005406)1.76333009
78Curly hair (HP:0002212)1.75884788
79Exotropia (HP:0000577)1.75631585
80Limb dystonia (HP:0002451)1.75192011
81Gait imbalance (HP:0002141)1.74421308
82Excessive salivation (HP:0003781)1.74135191
83Vaginal atresia (HP:0000148)1.74048513
84Deviation of the hallux (HP:0010051)1.73984744
85Hallux valgus (HP:0001822)1.72573886
86Abnormality of the distal phalanx of the thumb (HP:0009617)1.71958238
87Spinal rigidity (HP:0003306)1.71402040
88Broad ribs (HP:0000885)1.71214523
89Labial hypoplasia (HP:0000066)1.70143479
90Midline defect of the nose (HP:0004122)1.68402075
91Abnormality of complement system (HP:0005339)1.68106674
92Anterior segment dysgenesis (HP:0007700)1.68069035
93Diminished motivation (HP:0000745)1.67560572
94Cutaneous finger syndactyly (HP:0010554)1.67559196
95Genu recurvatum (HP:0002816)1.67484779
96Congenital primary aphakia (HP:0007707)1.64921844
97Eczematoid dermatitis (HP:0000976)1.64621309
98Increased corneal curvature (HP:0100692)1.64123675
99Keratoconus (HP:0000563)1.64123675
100Absent eyelashes (HP:0000561)1.64087075
101Prostate neoplasm (HP:0100787)1.63040033
102Neuronal loss in central nervous system (HP:0002529)1.62409300
103Abnormality of the labia majora (HP:0012881)1.62242523
104Joint laxity (HP:0001388)1.62127201
105Buphthalmos (HP:0000557)1.60618725
106Supranuclear gaze palsy (HP:0000605)1.60216024
107Coronal craniosynostosis (HP:0004440)1.60136698
108Broad thumb (HP:0011304)1.59925585
109Broad metatarsal (HP:0001783)1.59730368
110Abnormality of polysaccharide metabolism (HP:0011012)1.59091369
111Abnormality of glycosaminoglycan metabolism (HP:0004371)1.59091369
112Abnormality of mucopolysaccharide metabolism (HP:0011020)1.59091369
113Blue sclerae (HP:0000592)1.58845919
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.58060650
115Aplasia/Hypoplasia of the tongue (HP:0010295)1.57950492
116Peritonitis (HP:0002586)1.57368073
117Abnormality of the lower motor neuron (HP:0002366)1.57198092
118Chin dimple (HP:0010751)1.57120135
119Aplasia/Hypoplasia of the tibia (HP:0005772)1.56536905
120Action tremor (HP:0002345)1.56507068
121Barrel-shaped chest (HP:0001552)1.56349158
122Abnormality of the 4th metacarpal (HP:0010012)1.55927880
123Chronic hepatic failure (HP:0100626)1.55136181
124Disproportionate short-trunk short stature (HP:0003521)1.53615452
125Aplasia/Hypoplasia of the lens (HP:0008063)1.53545992
126Hypoventilation (HP:0002791)1.53520034
127Hypoplasia of the iris (HP:0007676)1.52836664
128Knee flexion contracture (HP:0006380)1.52522117
129Alopecia of scalp (HP:0002293)1.51827019
130Molar tooth sign on MRI (HP:0002419)1.51356238
131Abnormality of midbrain morphology (HP:0002418)1.51356238
132Tibial bowing (HP:0002982)1.51139762
133Optic nerve hypoplasia (HP:0000609)1.50972840
134Choroideremia (HP:0001139)1.50532999
135Small hand (HP:0200055)1.50338273
136Hyperextensible skin (HP:0000974)1.50288564
137True hermaphroditism (HP:0010459)1.49734472
138Hypoplastic female external genitalia (HP:0012815)1.49727767
139Focal segmental glomerulosclerosis (HP:0000097)1.48135417
140Hypoplastic pelvis (HP:0008839)1.47678619
141Urinary glycosaminoglycan excretion (HP:0003541)1.47213150
142Mucopolysacchariduria (HP:0008155)1.47213150
143Myocardial infarction (HP:0001658)1.46991292
144Ulnar claw (HP:0001178)1.46937233
145Atonic seizures (HP:0010819)1.46775395
146Coarse hair (HP:0002208)1.46680644
147Papillary thyroid carcinoma (HP:0002895)1.46548564
148Genetic anticipation (HP:0003743)1.45822651
149Arachnodactyly (HP:0001166)1.45124250
150Wide anterior fontanel (HP:0000260)1.44711367
151Nephrogenic diabetes insipidus (HP:0009806)1.44621648
152Short tibia (HP:0005736)1.44591437
153Short nail (HP:0001799)1.44362515
154Pulmonary artery stenosis (HP:0004415)1.43894666
155Absent hair (HP:0002298)1.43536322
156Septo-optic dysplasia (HP:0100842)1.43461376
157Short foot (HP:0001773)1.43004395
158Hip contracture (HP:0003273)1.42666359
159Abnormality of the ischium (HP:0003174)1.42570571
160Cutaneous syndactyly (HP:0012725)1.42484567
161Esophageal varix (HP:0002040)1.42184604
162Increased density of long bones (HP:0006392)1.41853761
163Hyperacusis (HP:0010780)1.41363878
164Hypothermia (HP:0002045)1.41312267
165Gastrointestinal carcinoma (HP:0002672)1.40994804
166Malignant gastrointestinal tract tumors (HP:0006749)1.40994804
167Wormian bones (HP:0002645)1.40262047
168Micropenis (HP:0000054)1.38852492
169Abnormality of the anterior chamber (HP:0000593)1.38593866
170Shawl scrotum (HP:0000049)1.37617223
171Nephronophthisis (HP:0000090)1.37313880
172Myelomeningocele (HP:0002475)1.36676389
173Adactyly (HP:0009776)1.36289934
174Narrow forehead (HP:0000341)1.35998290
175Occipital encephalocele (HP:0002085)1.35681503
176Large earlobe (HP:0009748)1.35594763
177Postaxial hand polydactyly (HP:0001162)1.34662902
178Renal hypoplasia (HP:0000089)1.34615668
179Congenital sensorineural hearing impairment (HP:0008527)1.34449683

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR25.69819359
2LATS13.85534133
3CASK3.24261654
4BCR2.73516403
5LATS22.64623073
6EPHB22.56806506
7PINK12.29664334
8PDK22.24708768
9CAMK1D2.19141939
10INSRR2.12440426
11PAK42.08312472
12CAMK1G1.88164352
13MAP3K41.87769993
14PDGFRA1.87133106
15WNK31.84636162
16EPHA31.79650237
17DMPK1.78611237
18TRIM281.77751975
19GRK71.72954010
20TTN1.68689151
21LMTK21.65240332
22EPHB11.59781802
23RIPK11.59684252
24MYLK1.59199427
25TRIB31.58415017
26MAP2K71.57322053
27PAK21.52272142
28STK31.52135465
29DDR21.51096036
30CSNK1G11.50255674
31STK38L1.48379235
32FRK1.48354884
33MAPK151.46788658
34AKT31.45405431
35CSNK1G21.43577904
36PTK61.42233189
37MAP4K21.39221765
38BRSK21.38606016
39CSNK1G31.37856399
40FER1.37391192
41CSF1R1.34446643
42MOS1.32980583
43STK101.31325286
44ADRBK21.27063222
45PNCK1.26413366
46NTRK11.25811102
47TIE11.25140425
48FGFR21.23924319
49PDGFRB1.22931145
50GRK11.22745341
51PTK21.19424423
52CDK121.18858239
53STK391.18033711
54TNIK1.16474426
55TYRO31.15627320
56ERBB31.13220946
57MARK11.12548078
58PTK2B1.11372136
59PRKCE1.11285240
60NEK91.04555082
61TYK21.04237903
62TBK11.01167699
63PAK60.98907815
64MINK10.98661593
65DYRK30.97507681
66PKN20.97011775
67RET0.96965229
68EPHA20.94676795
69ICK0.92673365
70MAP3K90.91120068
71MAP3K120.90227437
72LIMK10.89547889
73BRD40.87774523
74KSR20.85043525
75FGFR30.84156556
76CDK60.83441514
77FGR0.82055518
78MKNK20.79477783
79MAPK130.79251219
80DYRK1B0.79211092
81STK240.77410018
82SIK20.77376897
83ERBB20.77179100
84KDR0.75512928
85CHUK0.75153851
86PRKD30.75022993
87MAPK120.72373818
88NTRK20.71864476
89MST1R0.71014883
90ACVR1B0.70413394
91HCK0.70069682
92MTOR0.69641833
93DYRK20.69556448
94KSR10.69124943
95OXSR10.68896902
96GSK3A0.68636286
97JAK10.68547762
98FLT30.68347225
99MAPK70.67785616
100ERN10.67131327
101SGK4940.66913601
102SGK2230.66913601
103MAPKAPK50.65849621
104PRKCG0.65538557
105EGFR0.63659322
106ROCK10.63277264
107ERBB40.63154625
108CSNK1A1L0.62714949
109MAP3K60.61809582
110TGFBR10.60649457
111PRKD10.59452764
112IGF1R0.59328956
113CDK50.58821982
114CAMKK10.58179216
115BMPR1B0.57670786
116MATK0.57313651
117EIF2AK30.57302588
118MET0.57192633
119BMX0.56447907
120NEK60.56287799
121CDK90.55687540
122SGK20.54904031
123ABL10.53919063
124EPHA40.53227278
125CDK80.52541849
126MKNK10.52370396
127FGFR10.51102231
128TRPM70.49016419
129PLK30.48996957
130KIT0.48854180
131PLK20.48788297
132PIK3CA0.47781006
133PAK30.47622827
134WNK40.47479628
135NUAK10.47346101
136ROCK20.46983558
137INSR0.46262146
138CAMK2A0.46017466
139CSK0.45702913
140MELK0.45612975
141PKN10.45292454
142MAPKAPK20.44466592
143CAMK40.44321609
144RPS6KA40.42694526
145ADRBK10.41604154
146MAP3K140.40521357
147CSNK1A10.39698805
148ABL20.39411557
149STK380.39250104
150PIM20.38853808
151PRKG20.38094326
152SRC0.37580390
153CDK180.37139770
154MARK30.36498521
155PRKAA20.36048031
156NEK20.35858342
157NTRK30.35038365
158CDK140.34910369
159TESK10.34605677

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosaminoglycan degradation_Homo sapiens_hsa005312.31807429
2Protein export_Homo sapiens_hsa030602.06294129
3Nicotine addiction_Homo sapiens_hsa050332.03891504
4Adherens junction_Homo sapiens_hsa045201.95930399
5Staphylococcus aureus infection_Homo sapiens_hsa051501.78051326
6Circadian rhythm_Homo sapiens_hsa047101.73452801
7Phototransduction_Homo sapiens_hsa047441.67234843
8Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.64903103
9Osteoclast differentiation_Homo sapiens_hsa043801.63479553
10Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.63016373
11Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62573668
12Lysosome_Homo sapiens_hsa041421.60550254
13Pancreatic cancer_Homo sapiens_hsa052121.59075296
14Chronic myeloid leukemia_Homo sapiens_hsa052201.58849249
15Steroid biosynthesis_Homo sapiens_hsa001001.58403334
16Basal transcription factors_Homo sapiens_hsa030221.55519192
17Focal adhesion_Homo sapiens_hsa045101.55215576
18Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.52836308
19Leishmaniasis_Homo sapiens_hsa051401.50763130
20Other glycan degradation_Homo sapiens_hsa005111.50382449
21Renal cell carcinoma_Homo sapiens_hsa052111.47898483
22ECM-receptor interaction_Homo sapiens_hsa045121.47322673
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.47018663
24Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45811948
25Toxoplasmosis_Homo sapiens_hsa051451.43261046
26Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42931580
27Small cell lung cancer_Homo sapiens_hsa052221.41834650
28GABAergic synapse_Homo sapiens_hsa047271.40955815
29Pertussis_Homo sapiens_hsa051331.39373438
30Proteoglycans in cancer_Homo sapiens_hsa052051.38034215
31Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.37141224
32Colorectal cancer_Homo sapiens_hsa052101.36585628
33Axon guidance_Homo sapiens_hsa043601.35842760
34MicroRNAs in cancer_Homo sapiens_hsa052061.34669690
35Cocaine addiction_Homo sapiens_hsa050301.34586270
36Notch signaling pathway_Homo sapiens_hsa043301.34002940
37Glutamatergic synapse_Homo sapiens_hsa047241.33709708
38Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.33701815
39Leukocyte transendothelial migration_Homo sapiens_hsa046701.33685966
40Hippo signaling pathway_Homo sapiens_hsa043901.33648860
41Vibrio cholerae infection_Homo sapiens_hsa051101.32639555
42Toll-like receptor signaling pathway_Homo sapiens_hsa046201.31869017
43Viral myocarditis_Homo sapiens_hsa054161.30924295
44TGF-beta signaling pathway_Homo sapiens_hsa043501.30785972
45Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.27967808
46Dopaminergic synapse_Homo sapiens_hsa047281.27958122
47Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.26636877
48Regulation of actin cytoskeleton_Homo sapiens_hsa048101.26405308
49Dilated cardiomyopathy_Homo sapiens_hsa054141.23616971
50Malaria_Homo sapiens_hsa051441.23402785
51Amoebiasis_Homo sapiens_hsa051461.23253120
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.19097142
53Dorso-ventral axis formation_Homo sapiens_hsa043201.16812557
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.15991987
55Protein digestion and absorption_Homo sapiens_hsa049741.11443923
56Rap1 signaling pathway_Homo sapiens_hsa040151.10261925
57Tuberculosis_Homo sapiens_hsa051521.08307223
58Salmonella infection_Homo sapiens_hsa051321.08202186
59TNF signaling pathway_Homo sapiens_hsa046681.06372160
60Serotonergic synapse_Homo sapiens_hsa047261.06239719
61Shigellosis_Homo sapiens_hsa051311.04926801
62Endometrial cancer_Homo sapiens_hsa052131.04883307
63Endocytosis_Homo sapiens_hsa041441.04139164
64Long-term depression_Homo sapiens_hsa047301.03489491
65Phagosome_Homo sapiens_hsa041451.02721124
66Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02285335
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.01757426
68Glioma_Homo sapiens_hsa052141.00716821
69Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.99704830
70Circadian entrainment_Homo sapiens_hsa047130.98941623
71Sphingolipid metabolism_Homo sapiens_hsa006000.98717551
72Synaptic vesicle cycle_Homo sapiens_hsa047210.98650869
73Prion diseases_Homo sapiens_hsa050200.97739631
74Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.97673111
75Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.97268255
76Platelet activation_Homo sapiens_hsa046110.96206834
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.96023046
78VEGF signaling pathway_Homo sapiens_hsa043700.95738350
79Apoptosis_Homo sapiens_hsa042100.95040984
80Pathways in cancer_Homo sapiens_hsa052000.94166539
81B cell receptor signaling pathway_Homo sapiens_hsa046620.94061526
82Tight junction_Homo sapiens_hsa045300.93877484
83Chemokine signaling pathway_Homo sapiens_hsa040620.93438781
84Neurotrophin signaling pathway_Homo sapiens_hsa047220.92572301
85Morphine addiction_Homo sapiens_hsa050320.91928860
86Basal cell carcinoma_Homo sapiens_hsa052170.89570823
87Melanoma_Homo sapiens_hsa052180.89002928
88Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.86683338
89Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.85955167
90Taste transduction_Homo sapiens_hsa047420.85598799
91Prostate cancer_Homo sapiens_hsa052150.85250363
92Hepatitis B_Homo sapiens_hsa051610.84137412
93Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83424729
94Ras signaling pathway_Homo sapiens_hsa040140.82890543
95Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.82464497
96ErbB signaling pathway_Homo sapiens_hsa040120.80317620
97Influenza A_Homo sapiens_hsa051640.79549330
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.78193640
99Estrogen signaling pathway_Homo sapiens_hsa049150.78149250
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.77520968
101p53 signaling pathway_Homo sapiens_hsa041150.77025530
102MAPK signaling pathway_Homo sapiens_hsa040100.75682336
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.75622690
104Bladder cancer_Homo sapiens_hsa052190.75436798
105FoxO signaling pathway_Homo sapiens_hsa040680.73647291
106PI3K-Akt signaling pathway_Homo sapiens_hsa041510.73540587
107Prolactin signaling pathway_Homo sapiens_hsa049170.73142879
108Ovarian steroidogenesis_Homo sapiens_hsa049130.73138169
109Selenocompound metabolism_Homo sapiens_hsa004500.71751238
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.70603800
111Wnt signaling pathway_Homo sapiens_hsa043100.70338755
112NF-kappa B signaling pathway_Homo sapiens_hsa040640.69962342
113GnRH signaling pathway_Homo sapiens_hsa049120.69469526
114Renin secretion_Homo sapiens_hsa049240.69091896
115Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69065692
116Hedgehog signaling pathway_Homo sapiens_hsa043400.68905806
117Mineral absorption_Homo sapiens_hsa049780.68896559
118HIF-1 signaling pathway_Homo sapiens_hsa040660.68069718
119Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.67496036
120Rheumatoid arthritis_Homo sapiens_hsa053230.66708233
121HTLV-I infection_Homo sapiens_hsa051660.65839637
122Transcriptional misregulation in cancer_Homo sapiens_hsa052020.65759801
123Sulfur metabolism_Homo sapiens_hsa009200.65314583
124Non-small cell lung cancer_Homo sapiens_hsa052230.64725872
125Oocyte meiosis_Homo sapiens_hsa041140.64653388
126mTOR signaling pathway_Homo sapiens_hsa041500.63845316
127Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63499578
128Cholinergic synapse_Homo sapiens_hsa047250.63398916
129NOD-like receptor signaling pathway_Homo sapiens_hsa046210.63167124
130Ether lipid metabolism_Homo sapiens_hsa005650.63134737
131Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62969044
132Measles_Homo sapiens_hsa051620.62579152
133Choline metabolism in cancer_Homo sapiens_hsa052310.62391798
134Gap junction_Homo sapiens_hsa045400.62188642
135Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60349647
136Salivary secretion_Homo sapiens_hsa049700.58468259
137Vascular smooth muscle contraction_Homo sapiens_hsa042700.57760722
138Collecting duct acid secretion_Homo sapiens_hsa049660.55114257
139Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.54424938
140Melanogenesis_Homo sapiens_hsa049160.54345490
141Insulin secretion_Homo sapiens_hsa049110.52450805
142Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52297374
143Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52108066
144cAMP signaling pathway_Homo sapiens_hsa040240.51776245
145Amphetamine addiction_Homo sapiens_hsa050310.51722776
146Propanoate metabolism_Homo sapiens_hsa006400.51256089
147Gastric acid secretion_Homo sapiens_hsa049710.50795856
148Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.50427631
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.48093247
150Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.46757710
151Oxytocin signaling pathway_Homo sapiens_hsa049210.44832865
152Olfactory transduction_Homo sapiens_hsa047400.38805608
153Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.38743979
154Steroid hormone biosynthesis_Homo sapiens_hsa001400.38029594
155Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37957381
156alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.36704753
157Folate biosynthesis_Homo sapiens_hsa007900.34777673
158Primary bile acid biosynthesis_Homo sapiens_hsa001200.32864424
159AMPK signaling pathway_Homo sapiens_hsa041520.32415727

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