CTU2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is involved in the post-transcriptional modification of transfer RNAs (tRNAs). The encoded protein plays a role in thiolation of uridine residue present at the wobble position in a subset of tRNAs, resulting in enhanced codon reading accuracy. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1viral transcription (GO:0019083)6.38724030
2GDP-mannose metabolic process (GO:0019673)6.28799407
3translational termination (GO:0006415)6.24017883
4ribosomal small subunit assembly (GO:0000028)5.95317404
5ribosomal small subunit biogenesis (GO:0042274)5.91218915
6maturation of SSU-rRNA (GO:0030490)5.90656349
7translational elongation (GO:0006414)5.53264053
8DNA deamination (GO:0045006)5.53053652
9proline biosynthetic process (GO:0006561)5.26960657
10ribosomal large subunit biogenesis (GO:0042273)5.26374974
11SRP-dependent cotranslational protein targeting to membrane (GO:0006614)5.24259054
12adenine nucleotide transport (GO:0051503)5.22936912
13translational initiation (GO:0006413)5.18454603
14protein targeting to ER (GO:0045047)5.11307954
15cotranslational protein targeting to membrane (GO:0006613)5.10498040
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.06509337
17cellular protein complex disassembly (GO:0043624)4.88216940
18establishment of protein localization to endoplasmic reticulum (GO:0072599)4.84795189
19viral life cycle (GO:0019058)4.84492430
20protein localization to endoplasmic reticulum (GO:0070972)4.82677217
21purine ribonucleotide transport (GO:0015868)4.82087082
22DNA strand renaturation (GO:0000733)4.73178917
23ribonucleoprotein complex biogenesis (GO:0022613)4.65472315
24DNA strand elongation involved in DNA replication (GO:0006271)4.59369876
25regulation of translational fidelity (GO:0006450)4.52783259
26formation of translation preinitiation complex (GO:0001731)4.50290296
27protein complex disassembly (GO:0043241)4.42573522
28DNA strand elongation (GO:0022616)4.37052054
29meiotic chromosome segregation (GO:0045132)4.27921142
30DNA replication initiation (GO:0006270)4.23917445
31macromolecular complex disassembly (GO:0032984)4.19352230
32telomere maintenance via semi-conservative replication (GO:0032201)4.13580819
33purine nucleotide transport (GO:0015865)4.07210766
34rRNA processing (GO:0006364)4.04923071
35DNA unwinding involved in DNA replication (GO:0006268)4.03756174
36ribosome biogenesis (GO:0042254)4.02264869
37nucleobase biosynthetic process (GO:0046112)3.97092776
38rRNA methylation (GO:0031167)3.93060819
39translation (GO:0006412)3.90085494
40rRNA metabolic process (GO:0016072)3.89969558
41DNA replication checkpoint (GO:0000076)3.84523003
42histone arginine methylation (GO:0034969)3.83544343
43spliceosomal snRNP assembly (GO:0000387)3.83427658
44nuclear-transcribed mRNA catabolic process (GO:0000956)3.83116179
45nucleoside transmembrane transport (GO:1901642)3.80960998
46protein insertion into membrane (GO:0051205)3.76122573
47UV protection (GO:0009650)3.74515596
48proteasome assembly (GO:0043248)3.68829286
49peptidyl-arginine N-methylation (GO:0035246)3.66824021
50peptidyl-arginine methylation (GO:0018216)3.66824021
51pseudouridine synthesis (GO:0001522)3.66814411
52mRNA catabolic process (GO:0006402)3.66260880
53folic acid-containing compound biosynthetic process (GO:0009396)3.64992757
54adenosine receptor signaling pathway (GO:0001973)3.63433604
55purine nucleobase biosynthetic process (GO:0009113)3.63396086
56RNA catabolic process (GO:0006401)3.56030638
57telomere maintenance via recombination (GO:0000722)3.56017924
58mitotic nuclear envelope reassembly (GO:0007084)3.55972199
59nuclear envelope reassembly (GO:0031468)3.55972199
60ribosome assembly (GO:0042255)3.50169968
61Golgi transport vesicle coating (GO:0048200)3.48877757
62COPI coating of Golgi vesicle (GO:0048205)3.48877757
63negative regulation of cell aging (GO:0090344)3.48615004
64proline metabolic process (GO:0006560)3.45948576
65cellular component biogenesis (GO:0044085)3.43496616
66iron-sulfur cluster assembly (GO:0016226)3.41370979
67metallo-sulfur cluster assembly (GO:0031163)3.41370979
68mitotic chromosome condensation (GO:0007076)3.40820934
69termination of RNA polymerase III transcription (GO:0006386)3.36423679
70transcription elongation from RNA polymerase III promoter (GO:0006385)3.36423679
71protein targeting to membrane (GO:0006612)3.35614601
72protein retention in ER lumen (GO:0006621)3.34605833
73telomere maintenance via telomere lengthening (GO:0010833)3.33976898
74tRNA methylation (GO:0030488)3.33764809
75spliceosomal complex assembly (GO:0000245)3.28621856
76mitotic recombination (GO:0006312)3.26452495
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.23954628
78base-excision repair, AP site formation (GO:0006285)3.21162811
79regulation of mammary gland epithelial cell proliferation (GO:0033599)3.20898526
80nucleotide-sugar biosynthetic process (GO:0009226)3.20172258
81negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.19904273
82protein maturation by protein folding (GO:0022417)3.18019301
83negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.17787452
84cellular response to ATP (GO:0071318)3.15257589
85DNA replication-dependent nucleosome assembly (GO:0006335)3.14836992
86DNA replication-dependent nucleosome organization (GO:0034723)3.14836992
87L-serine metabolic process (GO:0006563)3.14709059
88nucleoside transport (GO:0015858)3.12856089
89maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.12062665
90peptidyl-histidine modification (GO:0018202)3.11420376
91rRNA transcription (GO:0009303)3.11156963
92IMP biosynthetic process (GO:0006188)3.10130092
93deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.09784412
94snRNA metabolic process (GO:0016073)3.09695088
95mitotic nuclear envelope disassembly (GO:0007077)3.08094200
96negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.06293748
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.05696878
98DNA duplex unwinding (GO:0032508)3.05212326
99folic acid metabolic process (GO:0046655)3.04146629
100ncRNA 3-end processing (GO:0043628)3.03163054
101protein localization to kinetochore (GO:0034501)3.01416002
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.01361507
103positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.00171872
104nuclear envelope organization (GO:0006998)2.99274469
105nucleotide-excision repair, DNA gap filling (GO:0006297)2.98925755
106negative regulation of RNA splicing (GO:0033119)2.98144769
107viral mRNA export from host cell nucleus (GO:0046784)2.96667766
108* ncRNA processing (GO:0034470)2.96648710
109exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.96452640
110negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.95293809
111negative regulation of ligase activity (GO:0051352)2.95285955
112negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.95285955
113tRNA aminoacylation for protein translation (GO:0006418)2.95253163
114tRNA aminoacylation (GO:0043039)2.93692846
115amino acid activation (GO:0043038)2.93692846
116peptidyl-arginine omega-N-methylation (GO:0035247)2.93509851
117spliceosomal tri-snRNP complex assembly (GO:0000244)2.90559082
118transcription-coupled nucleotide-excision repair (GO:0006283)2.90242761
119mitochondrial fusion (GO:0008053)2.89956034
120regulation of translational termination (GO:0006449)2.89891847
121chromatin remodeling at centromere (GO:0031055)2.88184505
122regulation of translational elongation (GO:0006448)2.87062973
123CENP-A containing nucleosome assembly (GO:0034080)2.86510112
124DNA geometric change (GO:0032392)2.86194435
125pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.85440309
126mitotic metaphase plate congression (GO:0007080)2.85021019
127* ncRNA metabolic process (GO:0034660)2.83943711
128protein localization to chromosome, centromeric region (GO:0071459)2.83104637
129histone phosphorylation (GO:0016572)2.82891112
130rRNA modification (GO:0000154)2.82753224
131snRNA processing (GO:0016180)2.82456901
132regulation of mitochondrial translation (GO:0070129)2.82274577
133heterochromatin organization (GO:0070828)2.82070071
134pteridine-containing compound biosynthetic process (GO:0042559)2.81168547
135nuclear envelope disassembly (GO:0051081)2.80543231
136membrane disassembly (GO:0030397)2.80543231
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.79053013
138RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.78339929
139mRNA splicing, via spliceosome (GO:0000398)2.78339929
140RNA splicing, via transesterification reactions (GO:0000375)2.77887457
141nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.75811397
142G1/S transition of mitotic cell cycle (GO:0000082)2.74741362
143cell cycle G1/S phase transition (GO:0044843)2.74741362
144establishment of integrated proviral latency (GO:0075713)2.74593652
145regulation of protein heterodimerization activity (GO:0043497)2.74267996
146maturation of 5.8S rRNA (GO:0000460)2.73876423
147DNA replication-independent nucleosome assembly (GO:0006336)2.72786517
148DNA replication-independent nucleosome organization (GO:0034724)2.72786517
149IMP metabolic process (GO:0046040)2.72545827
150mitotic sister chromatid segregation (GO:0000070)2.71901683
151DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.71808602
152termination of RNA polymerase II transcription (GO:0006369)2.71251073
153nucleotide transmembrane transport (GO:1901679)2.71064724
154intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.68630071
155signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.68630071
156DNA-templated transcription, termination (GO:0006353)2.68087750
157retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.68035371
158protein complex localization (GO:0031503)2.67849971
159signal transduction involved in DNA damage checkpoint (GO:0072422)2.67826241
160signal transduction involved in DNA integrity checkpoint (GO:0072401)2.67826241
161pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.64868044
162dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.64489552
163RNA methylation (GO:0001510)2.64478559
164nucleobase-containing small molecule interconversion (GO:0015949)2.64209921
165* tRNA modification (GO:0006400)2.63348672
166mitochondrial RNA metabolic process (GO:0000959)2.60964701
167base-excision repair (GO:0006284)2.59924601
168protein targeting to mitochondrion (GO:0006626)2.57731453
169transcription from mitochondrial promoter (GO:0006390)2.54749668
170guanosine-containing compound biosynthetic process (GO:1901070)2.53726480
171G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.50717147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.43639898
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.50654124
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.07282586
4MYC_19079543_ChIP-ChIP_MESCs_Mouse3.16563564
5MYC_18358816_ChIP-ChIP_MESCs_Mouse2.95107213
6ETS1_20019798_ChIP-Seq_JURKAT_Human2.92859834
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.86260984
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81498579
9MYC_19030024_ChIP-ChIP_MESCs_Mouse2.78612707
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.78189851
11EST1_17652178_ChIP-ChIP_JURKAT_Human2.76473976
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.71111390
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.68584568
14SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.53272852
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48529918
16XRN2_22483619_ChIP-Seq_HELA_Human2.47303515
17CREB1_15753290_ChIP-ChIP_HEK293T_Human2.45701270
18FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44822153
19NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.29047597
20* VDR_23849224_ChIP-Seq_CD4+_Human2.14932964
21LXR_22292898_ChIP-Seq_THP-1_Human2.10861270
22DCP1A_22483619_ChIP-Seq_HELA_Human2.07928902
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.06642892
24MYC_22102868_ChIP-Seq_BL_Human2.00638429
25ELF1_17652178_ChIP-ChIP_JURKAT_Human2.00237884
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.99723380
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99011403
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98891726
29TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.91818047
30FOXP3_21729870_ChIP-Seq_TREG_Human1.91487618
31TTF2_22483619_ChIP-Seq_HELA_Human1.89834319
32GABP_19822575_ChIP-Seq_HepG2_Human1.89229298
33P68_20966046_ChIP-Seq_HELA_Human1.85953646
34E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.78487425
35TET1_21451524_ChIP-Seq_MESCs_Mouse1.73114447
36THAP11_20581084_ChIP-Seq_MESCs_Mouse1.71165677
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.69873130
38CIITA_25753668_ChIP-Seq_RAJI_Human1.66625347
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.63951170
40MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.63523674
41RACK7_27058665_Chip-Seq_MCF-7_Human1.62770405
42EGR1_19374776_ChIP-ChIP_THP-1_Human1.62305340
43MYCN_18555785_ChIP-Seq_MESCs_Mouse1.61643639
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.60890573
45E2F1_21310950_ChIP-Seq_MCF-7_Human1.58905080
46FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.57906406
47RARG_19884340_ChIP-ChIP_MEFs_Mouse1.56498599
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.56425518
49TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.55796129
50NANOG_18555785_ChIP-Seq_MESCs_Mouse1.55024563
51NOTCH1_21737748_ChIP-Seq_TLL_Human1.54550293
52* VDR_21846776_ChIP-Seq_THP-1_Human1.54074140
53YY1_21170310_ChIP-Seq_MESCs_Mouse1.53584423
54KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.51993260
55CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.50457644
56* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.47287057
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.42571546
58ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.42145646
59FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.41459721
60DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.40568170
61KDM5A_27292631_Chip-Seq_BREAST_Human1.39776864
62STAT3_1855785_ChIP-Seq_MESCs_Mouse1.37515596
63* FOXP1_21924763_ChIP-Seq_HESCs_Human1.36939375
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.36885573
65AR_21909140_ChIP-Seq_LNCAP_Human1.36285621
66ELF1_20517297_ChIP-Seq_JURKAT_Human1.36108808
67CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.35953607
68ERG_20887958_ChIP-Seq_HPC-7_Mouse1.35495261
69CTCF_27219007_Chip-Seq_ERYTHROID_Human1.34830163
70CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33080530
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31350750
72SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.30955974
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29544693
74BCOR_27268052_Chip-Seq_Bcells_Human1.29398279
75BCL6_27268052_Chip-Seq_Bcells_Human1.29229398
76ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.27946718
77ELK1_19687146_ChIP-ChIP_HELA_Human1.27631861
78STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27550134
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.27095927
80SA1_27219007_Chip-Seq_ERYTHROID_Human1.25711205
81PHF8_20622854_ChIP-Seq_HELA_Human1.23424720
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23355158
83KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23290058
84RARA_24833708_ChIP-Seq_LIVER_Mouse1.22113612
85CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.20927896
86CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20564232
87POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.19967689
88SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.19903573
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.19172552
90EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.19084228
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18694267
92YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18524653
93SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17475281
94KDM2B_26808549_Chip-Seq_DND41_Human1.17365681
95CTCF_21964334_Chip-Seq_Bcells_Human1.17104832
96SMC4_20622854_ChIP-Seq_HELA_Human1.16632721
97SPI1_23547873_ChIP-Seq_NB4_Human1.16310916
98RARB_24833708_ChIP-Seq_LIVER_Mouse1.15578668
99KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14875630
100NCOR1_26117541_ChIP-Seq_K562_Human1.14658484
101MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13797776
102TFEB_21752829_ChIP-Seq_HELA_Human1.13243481
103E2F1_20622854_ChIP-Seq_HELA_Human1.12320986
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.11040416
105* ATF3_27146783_Chip-Seq_COLON_Human1.10162547
106TBX5_21415370_ChIP-Seq_HL-1_Mouse1.09432908
107POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.09266263
108ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.09052878
109ERG_21242973_ChIP-ChIP_JURKAT_Human1.08225264
110* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.07456388
111SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.06965596
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.05772107
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.05494814
114ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.05257840
115* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04448958
116ZNF263_19887448_ChIP-Seq_K562_Human1.02520729
117SRY_22984422_ChIP-ChIP_TESTIS_Rat1.00676914
118MAF_26560356_Chip-Seq_TH1_Human0.98409905
119ELK1_22589737_ChIP-Seq_MCF10A_Human0.97100606
120BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96466951
121UTX_26944678_Chip-Seq_JUKART_Human0.95843603
122HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95585151
123MAF_26560356_Chip-Seq_TH2_Human0.95091928
124SOX2_18555785_ChIP-Seq_MESCs_Mouse0.94951974
125RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90913793
126* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90912367
127* SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90697203
128OCT4_18692474_ChIP-Seq_MEFs_Mouse0.90529338
129ELK3_25401928_ChIP-Seq_HUVEC_Human0.87743141
130MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.87319616
131MYC_18940864_ChIP-ChIP_HL60_Human0.86022493
132CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.85582361
133IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.85508014
134MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84951758
135CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.84215141
136CTCF_18555785_ChIP-Seq_MESCs_Mouse0.82796998
137PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.82403110

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.30376172
2MP0004957_abnormal_blastocyst_morpholog4.23164843
3MP0005171_absent_coat_pigmentation4.01643323
4MP0003111_abnormal_nucleus_morphology3.99086572
5MP0010094_abnormal_chromosome_stability3.73773653
6MP0003077_abnormal_cell_cycle3.38489889
7MP0001986_abnormal_taste_sensitivity3.21434784
8MP0005423_abnormal_somatic_nervous3.07922200
9MP0009379_abnormal_foot_pigmentation2.78400641
10MP0003136_yellow_coat_color2.77296102
11MP0002396_abnormal_hematopoietic_system2.66850614
12MP0008058_abnormal_DNA_repair2.65783772
13MP0008932_abnormal_embryonic_tissue2.50325661
14MP0008007_abnormal_cellular_replicative2.38725858
15MP0001188_hyperpigmentation2.34539262
16MP0008057_abnormal_DNA_replication2.33596533
17MP0009333_abnormal_splenocyte_physiolog2.26768284
18MP0000751_myopathy2.16234413
19MP0010352_gastrointestinal_tract_polyps2.15571860
20MP0000490_abnormal_crypts_of2.08071106
21MP0003763_abnormal_thymus_physiology2.05737053
22MP0001730_embryonic_growth_arrest2.05291159
23MP0000350_abnormal_cell_proliferation1.97289966
24MP0005451_abnormal_body_composition1.92467938
25MP0003786_premature_aging1.91540144
26MP0005501_abnormal_skin_physiology1.86121902
27MP0005058_abnormal_lysosome_morphology1.84849982
28MP0000678_abnormal_parathyroid_gland1.81818109
29MP0002877_abnormal_melanocyte_morpholog1.77527085
30MP0001661_extended_life_span1.76046445
31MP0003453_abnormal_keratinocyte_physiol1.73287189
32MP0005409_darkened_coat_color1.72475871
33MP0000015_abnormal_ear_pigmentation1.72399046
34MP0004808_abnormal_hematopoietic_stem1.70713211
35MP0005397_hematopoietic_system_phenotyp1.70040588
36MP0001545_abnormal_hematopoietic_system1.70040588
37MP0004381_abnormal_hair_follicle1.66625992
38MP0002398_abnormal_bone_marrow1.63267850
39MP0002019_abnormal_tumor_incidence1.63113812
40MP0004233_abnormal_muscle_weight1.62541210
41MP0000703_abnormal_thymus_morphology1.60454573
42MP0000003_abnormal_adipose_tissue1.56401816
43MP0002722_abnormal_immune_system1.55533050
44MP0001697_abnormal_embryo_size1.52372744
45MP0002080_prenatal_lethality1.52369825
46MP0000313_abnormal_cell_death1.51676760
47MP0003123_paternal_imprinting1.48152508
48MP0000689_abnormal_spleen_morphology1.46107341
49MP0005083_abnormal_biliary_tract1.45491914
50MP0000858_altered_metastatic_potential1.43109320
51MP0004858_abnormal_nervous_system1.39653963
52MP0005380_embryogenesis_phenotype1.39549705
53MP0001672_abnormal_embryogenesis/_devel1.39549705
54MP0005330_cardiomyopathy1.38090459
55MP0000747_muscle_weakness1.35539390
56MP0000685_abnormal_immune_system1.32919101
57MP0002429_abnormal_blood_cell1.31677750
58MP0003984_embryonic_growth_retardation1.26897093
59MP0001800_abnormal_humoral_immune1.26875503
60MP0001835_abnormal_antigen_presentation1.26490030
61MP0003718_maternal_effect1.25290072
62MP0000716_abnormal_immune_system1.24977252
63MP0002088_abnormal_embryonic_growth/wei1.24671644
64MP0004185_abnormal_adipocyte_glucose1.24317909
65MP0003436_decreased_susceptibility_to1.24036253
66MP0003567_abnormal_fetal_cardiomyocyte1.23806752
67MP0002085_abnormal_embryonic_tissue1.23455588
68MP0010307_abnormal_tumor_latency1.20880428
69MP0002249_abnormal_larynx_morphology1.19501540
70MP0009785_altered_susceptibility_to1.17798984
71MP0009278_abnormal_bone_marrow1.17293285
72MP0002420_abnormal_adaptive_immunity1.16904032
73MP0001819_abnormal_immune_cell1.16249361
74MP0001348_abnormal_lacrimal_gland1.15966856
75MP0005671_abnormal_response_to1.15467933
76MP0002723_abnormal_immune_serum1.14585679
77MP0002086_abnormal_extraembryonic_tissu1.13836826
78MP0002452_abnormal_antigen_presenting1.13762966
79MP0001853_heart_inflammation1.11741304
80MP0003303_peritoneal_inflammation1.11613250
81MP0000358_abnormal_cell_content/1.11601688
82MP0005174_abnormal_tail_pigmentation1.10094601
83MP0001346_abnormal_lacrimal_gland1.10010853
84MP0002084_abnormal_developmental_patter1.09099889
85MP0005000_abnormal_immune_tolerance1.08044040
86MP0002796_impaired_skin_barrier1.07946293
87MP0003315_abnormal_perineum_morphology1.07785221
88MP0000465_gastrointestinal_hemorrhage1.07424882
89MP0001849_ear_inflammation1.07076900
90MP0005025_abnormal_response_to1.06801049
91MP0002405_respiratory_system_inflammati1.05617597
92MP0000013_abnormal_adipose_tissue1.05032324
93MP0002160_abnormal_reproductive_system1.04632254
94MP0009840_abnormal_foam_cell1.04247089
95MP0004197_abnormal_fetal_growth/weight/1.00506655
96MP0002132_abnormal_respiratory_system0.98073999
97MP0002210_abnormal_sex_determination0.97160633
98MP0004782_abnormal_surfactant_physiolog0.94417239
99MP0010155_abnormal_intestine_physiology0.94097572
100MP0001502_abnormal_circadian_rhythm0.93476508
101MP0001873_stomach_inflammation0.93285179
102MP0010030_abnormal_orbit_morphology0.92736862
103MP0003186_abnormal_redox_activity0.92454191
104MP0000750_abnormal_muscle_regeneration0.91206204
105MP0002166_altered_tumor_susceptibility0.91154635
106MP0003119_abnormal_digestive_system0.90363180
107MP0003866_abnormal_defecation0.89062070
108MP0001145_abnormal_male_reproductive0.89028986
109MP0003221_abnormal_cardiomyocyte_apopto0.87034830
110MP0006054_spinal_hemorrhage0.86418619
111MP0009931_abnormal_skin_appearance0.86347363
112MP0005076_abnormal_cell_differentiation0.86015726
113MP0005623_abnormal_meninges_morphology0.85848726
114MP0005075_abnormal_melanosome_morpholog0.85670491
115MP0002006_tumorigenesis0.84904882
116MP0006036_abnormal_mitochondrial_physio0.84831870
117MP0008877_abnormal_DNA_methylation0.84509812
118MP0009672_abnormal_birth_weight0.82665388
119MP0003724_increased_susceptibility_to0.81734335
120MP0000759_abnormal_skeletal_muscle0.81444433
121MP0003806_abnormal_nucleotide_metabolis0.81232053
122MP0000477_abnormal_intestine_morphology0.81073970
123MP0004133_heterotaxia0.79989080
124MP0000537_abnormal_urethra_morphology0.78802024
125MP0005023_abnormal_wound_healing0.78349306
126MP0008260_abnormal_autophagy0.76044790
127MP0003448_altered_tumor_morphology0.73682461
128MP0005375_adipose_tissue_phenotype0.70279011
129MP0006035_abnormal_mitochondrial_morpho0.70268424
130MP0005384_cellular_phenotype0.69167852
131MP0005257_abnormal_intraocular_pressure0.68887864
132MP0001293_anophthalmia0.67790439
133MP0005621_abnormal_cell_physiology0.67206845
134MP0010771_integument_phenotype0.66548767
135MP0000653_abnormal_sex_gland0.66457498
136MP0002060_abnormal_skin_morphology0.66026034
137MP0005387_immune_system_phenotype0.65408752
138MP0001790_abnormal_immune_system0.65408752
139MP0003705_abnormal_hypodermis_morpholog0.64589957
140MP0001845_abnormal_inflammatory_respons0.64350307
141MP0001929_abnormal_gametogenesis0.64313307
142MP0002177_abnormal_outer_ear0.63691379
143MP0000538_abnormal_urinary_bladder0.61199255
144MP0001216_abnormal_epidermal_layer0.60838424
145MP0002075_abnormal_coat/hair_pigmentati0.60811367
146MP0002254_reproductive_system_inflammat0.60648200
147MP0010234_abnormal_vibrissa_follicle0.59923612
148MP0001968_abnormal_touch/_nociception0.59510877
149MP0005584_abnormal_enzyme/coenzyme_acti0.59192957
150MP0000367_abnormal_coat/_hair0.58287256

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.23490833
2Reticulocytopenia (HP:0001896)6.01589597
3Abnormal number of erythroid precursors (HP:0012131)5.79040778
4Testicular atrophy (HP:0000029)5.15405933
5Ulnar bowing (HP:0003031)4.84339429
6Macrocytic anemia (HP:0001972)4.41146663
7Pallor (HP:0000980)4.22740916
8Rib fusion (HP:0000902)3.91061922
9Vaginal fistula (HP:0004320)3.88754393
10Oral leukoplakia (HP:0002745)3.79136265
11Birth length less than 3rd percentile (HP:0003561)3.73281855
12Rectovaginal fistula (HP:0000143)3.65476639
13Rectal fistula (HP:0100590)3.65476639
14Breast hypoplasia (HP:0003187)3.61484998
15Facial hemangioma (HP:0000329)3.60464819
16Intestinal fistula (HP:0100819)3.48640521
17Colon cancer (HP:0003003)3.45675389
18Thin bony cortex (HP:0002753)3.44640174
19Aplastic anemia (HP:0001915)3.42457457
20Rough bone trabeculation (HP:0100670)3.40179521
21Turricephaly (HP:0000262)3.35998073
22Annular pancreas (HP:0001734)3.32222708
23Selective tooth agenesis (HP:0001592)3.22064223
24Aplasia/Hypoplasia of the sacrum (HP:0008517)3.21180393
25Ragged-red muscle fibers (HP:0003200)3.20055387
26Multiple enchondromatosis (HP:0005701)3.10335268
27Degeneration of anterior horn cells (HP:0002398)2.99816641
28Abnormality of the anterior horn cell (HP:0006802)2.99816641
29Absent thumb (HP:0009777)2.95400627
30Trismus (HP:0000211)2.94851281
31Carpal bone hypoplasia (HP:0001498)2.94307838
32Myopathic facies (HP:0002058)2.92592376
33Thrombocytosis (HP:0001894)2.88966416
34Anteriorly placed anus (HP:0001545)2.88142156
35Microretrognathia (HP:0000308)2.86511601
36Patellar aplasia (HP:0006443)2.77147110
37Aplasia/Hypoplasia of the patella (HP:0006498)2.71510576
38Abnormality of the intrinsic pathway (HP:0010989)2.70999609
39Male infertility (HP:0003251)2.61784095
40Hemorrhage of the eye (HP:0011885)2.61325432
41Increased intramyocellular lipid droplets (HP:0012240)2.60455917
42Cerebral hypomyelination (HP:0006808)2.59774796
43Abnormal gallbladder physiology (HP:0012438)2.56629030
44Cholecystitis (HP:0001082)2.56629030
45Basal cell carcinoma (HP:0002671)2.53642690
46Cholelithiasis (HP:0001081)2.53319785
47Premature ovarian failure (HP:0008209)2.52183290
48Capillary hemangiomas (HP:0005306)2.51864140
49Decreased activity of mitochondrial respiratory chain (HP:0008972)2.50975243
50Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.50975243
51Coronal craniosynostosis (HP:0004440)2.49749186
52Increased muscle lipid content (HP:0009058)2.49476571
53Distal upper limb amyotrophy (HP:0007149)2.45216587
54Upper limb amyotrophy (HP:0009129)2.45216587
55Horseshoe kidney (HP:0000085)2.44217451
56Progressive muscle weakness (HP:0003323)2.40510996
57Abnormality of reticulocytes (HP:0004312)2.37514965
58IgM deficiency (HP:0002850)2.37340302
59Neoplasm of the pancreas (HP:0002894)2.37226469
60Progressive external ophthalmoplegia (HP:0000590)2.36894629
61Renal Fanconi syndrome (HP:0001994)2.34000114
62Aplasia of the musculature (HP:0100854)2.33984943
63Increased hepatocellular lipid droplets (HP:0006565)2.33717168
64Cleft eyelid (HP:0000625)2.33688019
65Premature graying of hair (HP:0002216)2.33192914
6611 pairs of ribs (HP:0000878)2.31476803
67Elevated erythrocyte sedimentation rate (HP:0003565)2.31152687
68Bowed forearm bones (HP:0003956)2.30563617
69Bowing of the arm (HP:0006488)2.30563617
70Lymphoma (HP:0002665)2.30041730
71Abnormal trabecular bone morphology (HP:0100671)2.29504927
72Delayed epiphyseal ossification (HP:0002663)2.27952734
73Cellular immunodeficiency (HP:0005374)2.27855729
74Hand muscle atrophy (HP:0009130)2.24302400
75Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.22720692
76Secondary amenorrhea (HP:0000869)2.22117091
77Hyperacusis (HP:0010780)2.21450933
78Abnormality of T cells (HP:0002843)2.21222545
79Triphalangeal thumb (HP:0001199)2.21148423
80Broad distal phalanx of finger (HP:0009836)2.20877428
81Amniotic constriction ring (HP:0009775)2.20625040
82Abnormality of placental membranes (HP:0011409)2.20625040
83Lipid accumulation in hepatocytes (HP:0006561)2.20522651
84Pancytopenia (HP:0001876)2.18355433
85Abnormal gallbladder morphology (HP:0012437)2.17585084
86Abnormality of T cell physiology (HP:0011840)2.15313549
87Akinesia (HP:0002304)2.13473094
88Abnormality of the preputium (HP:0100587)2.13007916
89Myelodysplasia (HP:0002863)2.12905255
90Type I transferrin isoform profile (HP:0003642)2.12599842
91Meckel diverticulum (HP:0002245)2.11853823
92Agnosia (HP:0010524)2.10834796
93Medulloblastoma (HP:0002885)2.10490642
94Reduced antithrombin III activity (HP:0001976)2.10355953
95Hypoplasia of the radius (HP:0002984)2.08838497
96Long palpebral fissure (HP:0000637)2.08197746
97Abnormality of the gallbladder (HP:0005264)2.06711436
98Rhabdomyosarcoma (HP:0002859)2.06374663
99Tracheoesophageal fistula (HP:0002575)2.06144903
100Abnormality of glycolysis (HP:0004366)2.05800615
101Abnormality of the ileum (HP:0001549)2.03945904
102Insomnia (HP:0100785)2.03423785
103Absent radius (HP:0003974)2.03188668
104Truncus arteriosus (HP:0001660)2.02241960
105Ependymoma (HP:0002888)2.02197589
106Hypertensive crisis (HP:0100735)2.01452340
107Thin ribs (HP:0000883)2.01183026
108Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.00443712
109Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.00007541
110Abnormal protein N-linked glycosylation (HP:0012347)2.00007541
111Abnormal protein glycosylation (HP:0012346)2.00007541
112Abnormal glycosylation (HP:0012345)2.00007541
113Glossoptosis (HP:0000162)1.99540963
114T lymphocytopenia (HP:0005403)1.99102522
115Bone marrow hypocellularity (HP:0005528)1.99057324
116Abnormal number of incisors (HP:0011064)1.98834864
117Congenital hip dislocation (HP:0001374)1.97049744
118Entropion (HP:0000621)1.95798199
119Joint stiffness (HP:0001387)1.95116705
120Increased serum lactate (HP:0002151)1.94894894
121Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94392772
122Atrophy/Degeneration involving motor neurons (HP:0007373)1.93050241
123Reticulocytosis (HP:0001923)1.90400589
124Atresia of the external auditory canal (HP:0000413)1.89479061
125Squamous cell carcinoma (HP:0002860)1.89317917
126Achilles tendon contracture (HP:0001771)1.89097118
127Respiratory difficulties (HP:0002880)1.88651086
128Aplasia involving forearm bones (HP:0009822)1.88257744
129Absent forearm bone (HP:0003953)1.88257744
130Amaurosis fugax (HP:0100576)1.87956482
131Microvesicular hepatic steatosis (HP:0001414)1.87835687
132Sparse eyelashes (HP:0000653)1.86583501
133Hepatocellular necrosis (HP:0001404)1.86218441
134Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.84524667
135Sparse lateral eyebrow (HP:0005338)1.84510482
136Dyschromatopsia (HP:0007641)1.83690948
137Abnormalities of placenta or umbilical cord (HP:0001194)1.82835546
138Short chin (HP:0000331)1.82297277
139Acute lymphatic leukemia (HP:0006721)1.82249667
140Choanal stenosis (HP:0000452)1.82150461
141Short thumb (HP:0009778)1.81392992
142Premature skin wrinkling (HP:0100678)1.80577592
143Abnormality of T cell number (HP:0011839)1.79641698
144Stridor (HP:0010307)1.79240575
145Popliteal pterygium (HP:0009756)1.78998812
146Abnormality of chromosome stability (HP:0003220)1.78841162
147Poikiloderma (HP:0001029)1.78037813
148Slender long bone (HP:0003100)1.77092212
149Depressed nasal ridge (HP:0000457)1.76943260
150Concave nail (HP:0001598)1.76128232
151Prominent nose (HP:0000448)1.74528653
152Poor head control (HP:0002421)1.73380483
153Exercise intolerance (HP:0003546)1.73343018
154B lymphocytopenia (HP:0010976)1.72951781
155Abnormality of B cell number (HP:0010975)1.72951781
156IgG deficiency (HP:0004315)1.72774325
157Combined immunodeficiency (HP:0005387)1.72084435
158Asplenia (HP:0001746)1.71648528
159Personality changes (HP:0000751)1.71297462
160Abnormality of cells of the lymphoid lineage (HP:0012140)1.70802770
161Chromosomal breakage induced by crosslinking agents (HP:0003221)1.70661302
162Pustule (HP:0200039)1.70549876
163Tongue fasciculations (HP:0001308)1.70427503
164Pulmonary fibrosis (HP:0002206)1.70099939
165Self-mutilation (HP:0000742)1.70083186
166Upper limb muscle weakness (HP:0003484)1.70025665
167Aplasia/Hypoplasia of the thymus (HP:0010515)1.69074044
168Severe combined immunodeficiency (HP:0004430)1.68654499
169Thick lower lip vermilion (HP:0000179)1.68407596
170Aplasia/Hypoplasia of the uvula (HP:0010293)1.65785981
171Chronic otitis media (HP:0000389)1.61878141
172Angiofibromas (HP:0010615)1.61713478
173Adenoma sebaceum (HP:0009720)1.61713478

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.14384831
2NME23.92657799
3WEE13.56289432
4TLK13.52861633
5EIF2AK13.30304445
6SMG13.03051842
7MAP3K102.74801935
8CDC72.57703046
9NEK22.35010200
10MAPK152.29260188
11STK162.28819776
12SIK12.27725053
13TESK22.15910060
14PRPF4B2.15432530
15MAP4K12.14693994
16MAP3K112.11060157
17SRPK12.02874239
18ICK1.96151278
19SCYL21.88184525
20ACVR1B1.82031799
21DYRK31.81545808
22PIM21.68911447
23RPS6KA41.64497432
24EIF2AK31.60072577
25KDR1.55735394
26MAP2K31.53227173
27RPS6KB21.50119030
28TSSK61.49113054
29CDK71.45667235
30VRK11.44415672
31VRK21.42887047
32EPHA21.36355956
33PLK11.36140410
34WNK41.35931153
35MST1R1.35814068
36CDK121.35141083
37BLK1.32004343
38PKN21.27826390
39ZAP701.24686377
40MAP3K81.23378400
41TTK1.23218874
42FLT31.16353625
43TGFBR11.16099715
44ATR1.13893536
45PBK1.12603223
46AURKB1.12078704
47PAK41.09791232
48PLK41.09650182
49AURKA1.08435687
50TAOK21.04330344
51BRSK21.04012393
52PASK1.01772901
53PRKD31.01601752
54IRAK30.99848304
55TAOK10.99263397
56EEF2K0.98975331
57MKNK20.98400295
58STK100.96866388
59CDK40.96483307
60IRAK20.95946313
61LRRK20.95477898
62ZAK0.94621712
63BMX0.93832751
64MAPK110.93556133
65MKNK10.93490953
66PIM10.92251402
67TTN0.92217836
68BTK0.89195262
69CDK11A0.86572304
70PRKD20.85304123
71CHEK20.84749842
72TRIB30.84270796
73JAK30.83989142
74PDK20.83034126
75IRAK40.82511467
76SIK30.82246452
77MTOR0.81523515
78CDK150.80951312
79TBK10.80298171
80MAPKAPK30.80125130
81MAP3K30.79186109
82KSR20.78374529
83NEK10.78064282
84SIK20.76011127
85CDK180.75855078
86TESK10.75712098
87PAK10.74840116
88MUSK0.74454078
89GRK60.73882671
90CDK140.73682328
91MAP2K20.70154721
92BRAF0.69501760
93PTK20.69269307
94LMTK20.68979512
95NME10.68506784
96TEC0.67823111
97CSNK2A20.67683392
98PDPK10.67114492
99TYK20.66769843
100ILK0.65950923
101CHEK10.65378171
102BCKDK0.63924169
103DAPK10.63351051
104PRKCI0.61153795
105CSNK2A10.60194256
106RPS6KA20.59594855
107CDK190.58998035
108ALK0.56962219
109ERN10.55612631
110IKBKB0.55151698
111RPS6KA50.54084369
112CDK20.53208872
113CDK80.53097852
114CSNK1G30.52946086
115DAPK30.51861788
116NLK0.51073688
117MET0.50694475
118KIT0.50282305
119ABL20.48846230
120CDK10.46861575
121BRSK10.46421540
122ATM0.45206951
123CDK60.44463745
124STK40.44196517
125LIMK10.43615906
126CSNK1A1L0.42579571
127CSF1R0.42402495
128TXK0.42263927
129MAP2K60.42167085
130EIF2AK20.41884438
131CCNB10.41409916
132SYK0.37949289
133RPS6KC10.37774083
134RPS6KL10.37774083
135RAF10.37402948
136PTK60.36632203
137PAK20.35978604
138BRD40.35585127
139ARAF0.35546077
140CLK10.35166541
141AKT20.34488152
142LCK0.34420581

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030105.28351031
2DNA replication_Homo sapiens_hsa030304.70089967
3Mismatch repair_Homo sapiens_hsa034303.61270579
4Proteasome_Homo sapiens_hsa030503.53618177
5RNA polymerase_Homo sapiens_hsa030203.53082714
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.52497074
7Spliceosome_Homo sapiens_hsa030403.28162451
8Base excision repair_Homo sapiens_hsa034102.80453919
9RNA transport_Homo sapiens_hsa030132.74147371
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.70034167
11Homologous recombination_Homo sapiens_hsa034402.68771035
12Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.67556889
13Pyrimidine metabolism_Homo sapiens_hsa002402.64506026
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.59695172
15Nucleotide excision repair_Homo sapiens_hsa034202.43477930
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.35042860
17One carbon pool by folate_Homo sapiens_hsa006702.26829023
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.12159546
19Cell cycle_Homo sapiens_hsa041101.98064855
20Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.85499276
21Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.75747406
22Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.72216100
23Fanconi anemia pathway_Homo sapiens_hsa034601.63307386
24Basal transcription factors_Homo sapiens_hsa030221.58007750
25RNA degradation_Homo sapiens_hsa030181.56490305
26p53 signaling pathway_Homo sapiens_hsa041151.43595886
27Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.42453611
28Folate biosynthesis_Homo sapiens_hsa007901.40896395
29Non-homologous end-joining_Homo sapiens_hsa034501.36200310
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.35779399
31Glycosaminoglycan degradation_Homo sapiens_hsa005311.32383727
32Epstein-Barr virus infection_Homo sapiens_hsa051691.28014677
33Primary immunodeficiency_Homo sapiens_hsa053401.27592992
34Purine metabolism_Homo sapiens_hsa002301.24782863
35mRNA surveillance pathway_Homo sapiens_hsa030151.24328915
36Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.21361548
37Antigen processing and presentation_Homo sapiens_hsa046121.17989745
38Pyruvate metabolism_Homo sapiens_hsa006201.13527960
39Herpes simplex infection_Homo sapiens_hsa051681.11787148
40Other glycan degradation_Homo sapiens_hsa005111.10470286
41Cyanoamino acid metabolism_Homo sapiens_hsa004601.08581093
42Systemic lupus erythematosus_Homo sapiens_hsa053220.99924365
43Protein export_Homo sapiens_hsa030600.99901708
44Steroid biosynthesis_Homo sapiens_hsa001000.96561136
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.91153650
46Thyroid cancer_Homo sapiens_hsa052160.88520302
47Pentose phosphate pathway_Homo sapiens_hsa000300.86740311
48Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.86378442
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.84637590
50HTLV-I infection_Homo sapiens_hsa051660.78499952
51* Sulfur relay system_Homo sapiens_hsa041220.78074582
52Viral carcinogenesis_Homo sapiens_hsa052030.76739183
53Huntingtons disease_Homo sapiens_hsa050160.76048466
54Drug metabolism - other enzymes_Homo sapiens_hsa009830.71990029
55Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71636394
56Legionellosis_Homo sapiens_hsa051340.71492980
57Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.70679617
58Parkinsons disease_Homo sapiens_hsa050120.69926678
59Measles_Homo sapiens_hsa051620.69703206
60Acute myeloid leukemia_Homo sapiens_hsa052210.68176966
61Apoptosis_Homo sapiens_hsa042100.67874252
62Vibrio cholerae infection_Homo sapiens_hsa051100.67731576
63Selenocompound metabolism_Homo sapiens_hsa004500.67291940
64Biosynthesis of amino acids_Homo sapiens_hsa012300.66694366
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.64571829
66Lysine degradation_Homo sapiens_hsa003100.63888456
67NF-kappa B signaling pathway_Homo sapiens_hsa040640.62452678
68Shigellosis_Homo sapiens_hsa051310.62167125
69Sphingolipid metabolism_Homo sapiens_hsa006000.61735948
70VEGF signaling pathway_Homo sapiens_hsa043700.61411710
71mTOR signaling pathway_Homo sapiens_hsa041500.60886116
72Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60808504
73Non-small cell lung cancer_Homo sapiens_hsa052230.55268540
74RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.52601812
75Oxidative phosphorylation_Homo sapiens_hsa001900.52366441
76Arginine and proline metabolism_Homo sapiens_hsa003300.52366011
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.52123563
78Hematopoietic cell lineage_Homo sapiens_hsa046400.50504943
79Small cell lung cancer_Homo sapiens_hsa052220.50310588
80Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.49417106
81Leishmaniasis_Homo sapiens_hsa051400.48539577
82Hippo signaling pathway_Homo sapiens_hsa043900.48229623
83Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.46879154
84Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45682374
85Bladder cancer_Homo sapiens_hsa052190.45593719
86Oocyte meiosis_Homo sapiens_hsa041140.44970581
87Hepatitis B_Homo sapiens_hsa051610.44008441
88Pancreatic cancer_Homo sapiens_hsa052120.42680909
89Phenylalanine metabolism_Homo sapiens_hsa003600.41992275
90AMPK signaling pathway_Homo sapiens_hsa041520.41963751
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41831061
92T cell receptor signaling pathway_Homo sapiens_hsa046600.40952056
93Arginine biosynthesis_Homo sapiens_hsa002200.40124907
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39647192
95Chronic myeloid leukemia_Homo sapiens_hsa052200.38425557
96Hedgehog signaling pathway_Homo sapiens_hsa043400.38385342
97B cell receptor signaling pathway_Homo sapiens_hsa046620.38183342
98Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38007900
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37947566
100Glutathione metabolism_Homo sapiens_hsa004800.37859041
101Influenza A_Homo sapiens_hsa051640.37395045
102Endocytosis_Homo sapiens_hsa041440.35874201
103Lysosome_Homo sapiens_hsa041420.35366223
104N-Glycan biosynthesis_Homo sapiens_hsa005100.35010977
105Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32691815
106Fatty acid elongation_Homo sapiens_hsa000620.32575888
107Endometrial cancer_Homo sapiens_hsa052130.32572698
108Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.32537266
109Colorectal cancer_Homo sapiens_hsa052100.32001346
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.31918034
111Prion diseases_Homo sapiens_hsa050200.31877718
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31065182
113Inositol phosphate metabolism_Homo sapiens_hsa005620.31010796
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.30486657
115Notch signaling pathway_Homo sapiens_hsa043300.30301434
116Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.30103151
117HIF-1 signaling pathway_Homo sapiens_hsa040660.29657888
118Insulin signaling pathway_Homo sapiens_hsa049100.29414006
119Alcoholism_Homo sapiens_hsa050340.28808535
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.27820742
121MicroRNAs in cancer_Homo sapiens_hsa052060.25616436
122Basal cell carcinoma_Homo sapiens_hsa052170.24484856
123Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23966341
124Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.23587450
125Carbon metabolism_Homo sapiens_hsa012000.23158144
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.22933301
127Galactose metabolism_Homo sapiens_hsa000520.21585628
128Vitamin B6 metabolism_Homo sapiens_hsa007500.21566240
129Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20615009
130Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.20265442
131Central carbon metabolism in cancer_Homo sapiens_hsa052300.19793321
132Leukocyte transendothelial migration_Homo sapiens_hsa046700.19460766
133Fructose and mannose metabolism_Homo sapiens_hsa000510.18457844
134Metabolic pathways_Homo sapiens_hsa011000.18153669
135Pathways in cancer_Homo sapiens_hsa052000.18135817
136Toxoplasmosis_Homo sapiens_hsa051450.17971774
137Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.17673549
138Viral myocarditis_Homo sapiens_hsa054160.17584617
139Osteoclast differentiation_Homo sapiens_hsa043800.16976626
140Alzheimers disease_Homo sapiens_hsa050100.14429489

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