CTXN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1neurofilament cytoskeleton organization (GO:0060052)6.63882275
2neuron cell-cell adhesion (GO:0007158)5.33842927
3dopamine transport (GO:0015872)5.19094695
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.83671706
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.81131381
6synaptic vesicle exocytosis (GO:0016079)4.66848284
7vocalization behavior (GO:0071625)4.62127544
8dopamine biosynthetic process (GO:0042416)4.59141727
9ATP synthesis coupled proton transport (GO:0015986)4.49077839
10energy coupled proton transport, down electrochemical gradient (GO:0015985)4.49077839
11catecholamine transport (GO:0051937)4.27551707
12regulation of short-term neuronal synaptic plasticity (GO:0048172)4.18982416
13synaptic transmission, dopaminergic (GO:0001963)4.16474077
14regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.07810698
15ATP hydrolysis coupled proton transport (GO:0015991)4.07270791
16energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.07270791
17respiratory electron transport chain (GO:0022904)3.97798919
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.97266551
19positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96667724
20establishment of protein localization to mitochondrial membrane (GO:0090151)3.94327071
21electron transport chain (GO:0022900)3.90584005
22regulation of glutamate receptor signaling pathway (GO:1900449)3.89158998
23response to histamine (GO:0034776)3.86887854
24regulation of synaptic vesicle exocytosis (GO:2000300)3.85494476
25neuron recognition (GO:0008038)3.84167534
26pyrimidine nucleobase catabolic process (GO:0006208)3.83785367
27dendritic spine morphogenesis (GO:0060997)3.83206802
28gamma-aminobutyric acid signaling pathway (GO:0007214)3.83160483
29regulation of glutamate secretion (GO:0014048)3.82099906
30gamma-aminobutyric acid transport (GO:0015812)3.80869504
31regulation of protein kinase A signaling (GO:0010738)3.80458588
32neuron-neuron synaptic transmission (GO:0007270)3.79707464
33positive regulation of synapse assembly (GO:0051965)3.76923754
34regulation of dopamine secretion (GO:0014059)3.75419053
35cilium or flagellum-dependent cell motility (GO:0001539)3.75109973
36protein localization to synapse (GO:0035418)3.74958556
37C4-dicarboxylate transport (GO:0015740)3.68710975
38neurotransmitter secretion (GO:0007269)3.66528248
39auditory behavior (GO:0031223)3.66092267
40female mating behavior (GO:0060180)3.65742856
41neurotransmitter catabolic process (GO:0042135)3.64236744
42transferrin transport (GO:0033572)3.62830842
43serotonin metabolic process (GO:0042428)3.62157796
44presynaptic membrane assembly (GO:0097105)3.62121385
45regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.61715689
46regulation of dopamine metabolic process (GO:0042053)3.61510229
47regulation of catecholamine metabolic process (GO:0042069)3.61510229
48ionotropic glutamate receptor signaling pathway (GO:0035235)3.59672049
49neuronal action potential (GO:0019228)3.56959252
50transmission of nerve impulse (GO:0019226)3.53845300
51regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.53004187
52regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.53004187
53potassium ion homeostasis (GO:0055075)3.49373339
54urinary tract smooth muscle contraction (GO:0014848)3.48796217
55opioid receptor signaling pathway (GO:0038003)3.48346802
56glutamate secretion (GO:0014047)3.48110432
57hindbrain development (GO:0030902)3.46946487
58behavioral response to cocaine (GO:0048148)3.45988216
59mating behavior (GO:0007617)3.44507296
60neurotransmitter transport (GO:0006836)3.44215517
61positive regulation of synaptic transmission, GABAergic (GO:0032230)3.42911119
62nucleobase catabolic process (GO:0046113)3.41471803
63glutamate receptor signaling pathway (GO:0007215)3.41110337
64positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.40833024
65negative regulation of neurotransmitter transport (GO:0051589)3.40779948
66behavioral response to nicotine (GO:0035095)3.40248752
67chaperone-mediated protein transport (GO:0072321)3.40199520
68neurotransmitter biosynthetic process (GO:0042136)3.40195459
69presynaptic membrane organization (GO:0097090)3.39697235
70trivalent inorganic cation transport (GO:0072512)3.38356558
71ferric iron transport (GO:0015682)3.38356558
72synaptic vesicle maturation (GO:0016188)3.36950774
73regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.36162806
74positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.34676842
75primary amino compound metabolic process (GO:1901160)3.33213971
76regulation of synaptic vesicle transport (GO:1902803)3.33181840
77regulation of neurotransmitter levels (GO:0001505)3.32479316
78catechol-containing compound biosynthetic process (GO:0009713)3.31077511
79catecholamine biosynthetic process (GO:0042423)3.31077511
80synaptic transmission, glutamatergic (GO:0035249)3.29471070
81regulation of female receptivity (GO:0045924)3.28450086
82response to cocaine (GO:0042220)3.28060116
83regulation of vesicle fusion (GO:0031338)3.27533053
84inner mitochondrial membrane organization (GO:0007007)3.25460974
85retina layer formation (GO:0010842)3.25013254
86synaptic vesicle docking involved in exocytosis (GO:0016081)3.23129889
87striatum development (GO:0021756)3.22375868
88membrane depolarization during action potential (GO:0086010)3.22014187
89response to auditory stimulus (GO:0010996)3.19680325
90neuronal action potential propagation (GO:0019227)3.19448624
91regulation of synapse structural plasticity (GO:0051823)3.19276392
92neuromuscular process controlling posture (GO:0050884)3.17631746
93cell migration in hindbrain (GO:0021535)3.13081048
94neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.12899473
95positive regulation of inositol phosphate biosynthetic process (GO:0060732)3.11089090
96prepulse inhibition (GO:0060134)3.09854859
97histone arginine methylation (GO:0034969)3.08066649
98regulation of respiratory system process (GO:0044065)3.06689602
99locomotory exploration behavior (GO:0035641)3.06004291
100exploration behavior (GO:0035640)3.06001526
101negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.05615846
102negative regulation of synaptic transmission, GABAergic (GO:0032229)3.04889724
103neurotransmitter uptake (GO:0001504)3.04356669
104startle response (GO:0001964)3.04198613
105positive regulation of neurotransmitter transport (GO:0051590)3.04004579
106proline transport (GO:0015824)3.03304256
107long-term synaptic potentiation (GO:0060291)3.03002748
108response to amphetamine (GO:0001975)3.01717311
109maternal behavior (GO:0042711)3.01470266
110neurotransmitter-gated ion channel clustering (GO:0072578)3.00440771
111regulation of synaptic transmission, glutamatergic (GO:0051966)2.99571735
112response to insecticide (GO:0017085)2.99539215
113phenol-containing compound catabolic process (GO:0019336)2.99079229
114regulation of excitatory postsynaptic membrane potential (GO:0060079)2.97742861
115postsynaptic membrane organization (GO:0001941)2.97301668
116regulation of postsynaptic membrane potential (GO:0060078)2.96619229
117regulation of cAMP-dependent protein kinase activity (GO:2000479)2.96076225
118axonal fasciculation (GO:0007413)2.95846453
119protein localization to cilium (GO:0061512)2.95777654
120regulation of neurotransmitter uptake (GO:0051580)2.95570585
121positive regulation of amino acid transport (GO:0051957)2.94703281
122mechanosensory behavior (GO:0007638)2.94541201
123dendrite development (GO:0016358)2.93536919
124membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.93073026
125hydrogen ion transmembrane transport (GO:1902600)2.90553962
126regulation of long-term neuronal synaptic plasticity (GO:0048169)2.90155111
127membrane depolarization (GO:0051899)2.89488818
128phagosome maturation (GO:0090382)2.88967992
129positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.88111184
130detection of calcium ion (GO:0005513)2.84963303
131social behavior (GO:0035176)2.84015007
132intraspecies interaction between organisms (GO:0051703)2.84015007
133axonemal dynein complex assembly (GO:0070286)2.83291265
134behavioral defense response (GO:0002209)2.80933366
135behavioral fear response (GO:0001662)2.80933366
136positive regulation of action potential (GO:0045760)2.79897298
137adult walking behavior (GO:0007628)2.79551963
138negative regulation of membrane potential (GO:0045837)2.78480047
139positive regulation of vesicle fusion (GO:0031340)2.78337108
140positive regulation of amine transport (GO:0051954)2.76523680
141G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.73753000
142regulation of calcium ion-dependent exocytosis (GO:0017158)2.73328032
143righting reflex (GO:0060013)2.73285454
144cerebellar granule cell differentiation (GO:0021707)2.73051007
145chemosensory behavior (GO:0007635)2.72693930
146neuron maturation (GO:0042551)2.70475906
147regulation of feeding behavior (GO:0060259)2.68475925
148action potential (GO:0001508)2.67566998
149neuromuscular synaptic transmission (GO:0007274)2.66455275
150detection of light stimulus involved in visual perception (GO:0050908)2.65470815
151detection of light stimulus involved in sensory perception (GO:0050962)2.65470815
152regulation of respiratory gaseous exchange (GO:0043576)2.63671529
153regulation of synaptic transmission, GABAergic (GO:0032228)2.63033115

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.11171203
2GBX2_23144817_ChIP-Seq_PC3_Human3.91586651
3TAF15_26573619_Chip-Seq_HEK293_Human3.10292576
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95588347
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.82977812
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.75147759
7CTBP2_25329375_ChIP-Seq_LNCAP_Human2.56314785
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.53456995
9SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.51500068
10CTBP1_25329375_ChIP-Seq_LNCAP_Human2.38744958
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.38224242
12EZH2_27304074_Chip-Seq_ESCs_Mouse2.38077632
13ZFP57_27257070_Chip-Seq_ESCs_Mouse2.37675706
14SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.35163201
15SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.32624116
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.28335530
17TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.23638694
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.18887514
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.17711752
20RNF2_18974828_ChIP-Seq_MESCs_Mouse2.17711752
21GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.17133255
22MTF2_20144788_ChIP-Seq_MESCs_Mouse2.16224861
23* BMI1_23680149_ChIP-Seq_NPCS_Mouse2.13773970
24EED_16625203_ChIP-ChIP_MESCs_Mouse2.12983059
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.12176691
26IKZF1_21737484_ChIP-ChIP_HCT116_Human2.05453477
27REST_18959480_ChIP-ChIP_MESCs_Mouse2.04662698
28VDR_22108803_ChIP-Seq_LS180_Human2.01694526
29P300_19829295_ChIP-Seq_ESCs_Human2.00941947
30BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.00474999
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.99827487
32ZNF274_21170338_ChIP-Seq_K562_Hela1.92078447
33POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90190394
34SMAD4_21799915_ChIP-Seq_A2780_Human1.87909999
35SUZ12_27294783_Chip-Seq_ESCs_Mouse1.87719663
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85897562
37EZH2_27294783_Chip-Seq_ESCs_Mouse1.80443746
38FUS_26573619_Chip-Seq_HEK293_Human1.77364000
39IGF1R_20145208_ChIP-Seq_DFB_Human1.67677388
40RNF2_27304074_Chip-Seq_ESCs_Mouse1.66778117
41AR_21572438_ChIP-Seq_LNCaP_Human1.66703442
42TOP2B_26459242_ChIP-Seq_MCF-7_Human1.66677779
43CBX2_27304074_Chip-Seq_ESCs_Mouse1.66618132
44DROSHA_22980978_ChIP-Seq_HELA_Human1.66434599
45RARB_27405468_Chip-Seq_BRAIN_Mouse1.63912941
46PIAS1_25552417_ChIP-Seq_VCAP_Human1.61094822
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58056731
48NR3C1_23031785_ChIP-Seq_PC12_Mouse1.54382078
49RNF2_27304074_Chip-Seq_NSC_Mouse1.52765367
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.51842246
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.49735306
52ER_23166858_ChIP-Seq_MCF-7_Human1.48498057
53OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.48496163
54SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45832369
55FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.39652980
56AR_25329375_ChIP-Seq_VCAP_Human1.38555319
57UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.38363029
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.35059584
59SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.30996559
60SOX2_21211035_ChIP-Seq_LN229_Gbm1.29952501
61ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.26956256
62IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.23888136
63CBP_20019798_ChIP-Seq_JUKART_Human1.23888136
64TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.22597567
65JUN_21703547_ChIP-Seq_K562_Human1.21218155
66ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.19463393
67RUNX2_22187159_ChIP-Seq_PCA_Human1.19238823
68RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.18241198
69EWS_26573619_Chip-Seq_HEK293_Human1.16808931
70CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14543224
71STAT3_23295773_ChIP-Seq_U87_Human1.13911386
72CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13844918
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.12097535
74PRDM14_20953172_ChIP-Seq_ESCs_Human1.11603444
75TCF4_23295773_ChIP-Seq_U87_Human1.11186112
76CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11033503
77* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.10518710
78FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08302251
79TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.08195889
80MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.07929002
81MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.07363945
82AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.06842924
83ERG_21242973_ChIP-ChIP_JURKAT_Human1.06545867
84FLI1_27457419_Chip-Seq_LIVER_Mouse1.06507087
85PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.06050336
86BCAT_22108803_ChIP-Seq_LS180_Human1.05635900
87LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04210493
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.02937260
89CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.02431491
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.02232588
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.00892223
92AR_19668381_ChIP-Seq_PC3_Human0.96343928
93KDM2B_26808549_Chip-Seq_REH_Human0.96179783
94NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95407133
95TAL1_26923725_Chip-Seq_HPCs_Mouse0.95156786
96TP53_22573176_ChIP-Seq_HFKS_Human0.95030818
97RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.94448699
98TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94433943
99MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.94027356
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93492334
101POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.93492334
102SMAD4_21741376_ChIP-Seq_EPCs_Human0.93133308
103FLI1_21867929_ChIP-Seq_TH2_Mouse0.92443285
104TP53_18474530_ChIP-ChIP_U2OS_Human0.92315688
105GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.92111279
106P53_22387025_ChIP-Seq_ESCs_Mouse0.91991535
107CMYC_18555785_Chip-Seq_ESCs_Mouse0.91604435
108RING1B_27294783_Chip-Seq_ESCs_Mouse0.90955926
109RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.90950018
110MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.90817750
111KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90215081
112P53_22127205_ChIP-Seq_FIBROBLAST_Human0.89908345
113E2F1_18555785_Chip-Seq_ESCs_Mouse0.89418157

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.26904242
2MP0001529_abnormal_vocalization3.93617067
3MP0004859_abnormal_synaptic_plasticity3.71062786
4MP0002102_abnormal_ear_morphology3.38305030
5MP0003635_abnormal_synaptic_transmissio3.37192715
6MP0006276_abnormal_autonomic_nervous3.37172642
7MP0009745_abnormal_behavioral_response3.17595081
8MP0009046_muscle_twitch3.00894172
9MP0002064_seizures2.97115999
10MP0001968_abnormal_touch/_nociception2.90073463
11MP0002822_catalepsy2.90043540
12MP0001440_abnormal_grooming_behavior2.84643758
13MP0003122_maternal_imprinting2.78455704
14MP0001501_abnormal_sleep_pattern2.77115528
15MP0002063_abnormal_learning/memory/cond2.75473038
16MP0002572_abnormal_emotion/affect_behav2.73199608
17MP0001905_abnormal_dopamine_level2.69860249
18MP0002736_abnormal_nociception_after2.63355707
19MP0004270_analgesia2.56061551
20MP0002272_abnormal_nervous_system2.54130606
21MP0002735_abnormal_chemical_nociception2.52042442
22MP0002734_abnormal_mechanical_nocicepti2.47239005
23MP0005645_abnormal_hypothalamus_physiol2.46251460
24MP0002837_dystrophic_cardiac_calcinosis2.34444325
25MP0005423_abnormal_somatic_nervous2.27108398
26MP0001986_abnormal_taste_sensitivity2.20095070
27MP0004924_abnormal_behavior2.13319972
28MP0005386_behavior/neurological_phenoty2.13319972
29MP0002733_abnormal_thermal_nociception2.11909800
30MP0001486_abnormal_startle_reflex2.10400511
31MP0001970_abnormal_pain_threshold2.05404667
32MP0002067_abnormal_sensory_capabilities1.94925176
33MP0004142_abnormal_muscle_tone1.83704709
34MP0002184_abnormal_innervation1.75880165
35MP0002557_abnormal_social/conspecific_i1.74236587
36MP0001984_abnormal_olfaction1.65435672
37MP0000778_abnormal_nervous_system1.61300362
38MP0002876_abnormal_thyroid_physiology1.60236128
39MP0003195_calcinosis1.57144838
40MP0010386_abnormal_urinary_bladder1.52552478
41MP0001188_hyperpigmentation1.47819814
42MP0005646_abnormal_pituitary_gland1.46648056
43MP0003787_abnormal_imprinting1.40461598
44MP0001502_abnormal_circadian_rhythm1.39418992
45MP0002909_abnormal_adrenal_gland1.38529552
46MP0005187_abnormal_penis_morphology1.35326007
47MP0003329_amyloid_beta_deposits1.34766668
48MP0008872_abnormal_physiological_respon1.32657688
49MP0000013_abnormal_adipose_tissue1.32656355
50MP0003879_abnormal_hair_cell1.31838046
51MP0002066_abnormal_motor_capabilities/c1.29295518
52MP0005379_endocrine/exocrine_gland_phen1.25099878
53MP0003011_delayed_dark_adaptation1.22094295
54MP0002882_abnormal_neuron_morphology1.19013615
55MP0000955_abnormal_spinal_cord1.18410072
56MP0004043_abnormal_pH_regulation1.16601705
57MP0008569_lethality_at_weaning1.15300984
58MP0000751_myopathy1.13290217
59MP0004510_myositis1.13081533
60MP0004811_abnormal_neuron_physiology1.12668509
61MP0004133_heterotaxia1.10669514
62MP0005535_abnormal_body_temperature1.07159439
63MP0003121_genomic_imprinting1.06906901
64MP0003283_abnormal_digestive_organ1.05987233
65MP0005551_abnormal_eye_electrophysiolog1.05350165
66MP0002069_abnormal_eating/drinking_beha1.04018917
67MP0001664_abnormal_digestion1.01763030
68MP0008875_abnormal_xenobiotic_pharmacok1.01756521
69MP0000569_abnormal_digit_pigmentation0.97198683
70MP0006072_abnormal_retinal_apoptosis0.96632794
71MP0009780_abnormal_chondrocyte_physiolo0.96455779
72MP0002693_abnormal_pancreas_physiology0.95366686
73MP0000372_irregular_coat_pigmentation0.95246755
74MP0002163_abnormal_gland_morphology0.94945968
75MP0006035_abnormal_mitochondrial_morpho0.93968741
76MP0000427_abnormal_hair_cycle0.93588607
77MP0004742_abnormal_vestibular_system0.92212675
78MP0003633_abnormal_nervous_system0.91604283
79MP0002638_abnormal_pupillary_reflex0.90298717
80MP0002160_abnormal_reproductive_system0.89880957
81MP0002229_neurodegeneration0.89132283
82MP0005389_reproductive_system_phenotype0.88375314
83MP0005253_abnormal_eye_physiology0.87928781
84MP0002938_white_spotting0.87506146
85MP0004145_abnormal_muscle_electrophysio0.87477440
86MP0002152_abnormal_brain_morphology0.86953427
87MP0000631_abnormal_neuroendocrine_gland0.86325388
88MP0003631_nervous_system_phenotype0.84674354
89MP0003123_paternal_imprinting0.84418225
90MP0004147_increased_porphyrin_level0.84119022
91MP0005248_abnormal_Harderian_gland0.83741472
92MP0005409_darkened_coat_color0.83280362
93MP0001485_abnormal_pinna_reflex0.82317359
94MP0003315_abnormal_perineum_morphology0.81992078
95MP0002332_abnormal_exercise_endurance0.80692945
96MP0000538_abnormal_urinary_bladder0.79039715
97MP0009379_abnormal_foot_pigmentation0.78725003
98MP0002090_abnormal_vision0.78334180
99MP0003183_abnormal_peptide_metabolism0.78188800
100MP0003868_abnormal_feces_composition0.78115934
101MP0005394_taste/olfaction_phenotype0.77438385
102MP0005499_abnormal_olfactory_system0.77438385
103MP0001944_abnormal_pancreas_morphology0.76101821
104MP0001963_abnormal_hearing_physiology0.76074463
105MP0002752_abnormal_somatic_nervous0.75888013
106MP0004085_abnormal_heartbeat0.75303216
107MP0008874_decreased_physiological_sensi0.74558243
108MP0001299_abnormal_eye_distance/0.73462648
109MP0002751_abnormal_autonomic_nervous0.73147904
110MP0004858_abnormal_nervous_system0.72218204
111MP0003634_abnormal_glial_cell0.66435850
112MP0001943_abnormal_respiration0.63977801
113MP0006036_abnormal_mitochondrial_physio0.63792227
114MP0003632_abnormal_nervous_system0.61003118
115MP0008877_abnormal_DNA_methylation0.59238692
116MP0005410_abnormal_fertilization0.58653096
117MP0003959_abnormal_lean_body0.54718702
118MP0005171_absent_coat_pigmentation0.54509497
119MP0003690_abnormal_glial_cell0.54507418
120MP0004215_abnormal_myocardial_fiber0.54036081
121MP0004885_abnormal_endolymph0.52958387
122MP0000604_amyloidosis0.51851559
123MP0000639_abnormal_adrenal_gland0.51481213
124MP0004036_abnormal_muscle_relaxation0.50867020
125MP0000747_muscle_weakness0.49931253

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.27972132
2Limb dystonia (HP:0002451)5.55664979
3Visual hallucinations (HP:0002367)4.80390424
4Acute necrotizing encephalopathy (HP:0006965)4.79527386
5Atonic seizures (HP:0010819)4.71685460
6Myokymia (HP:0002411)4.61895534
7Focal seizures (HP:0007359)4.59913005
8Abnormal mitochondria in muscle tissue (HP:0008316)4.46444808
9Progressive macrocephaly (HP:0004481)4.21212060
10Mitochondrial inheritance (HP:0001427)4.01657393
11Pheochromocytoma (HP:0002666)4.00162765
12Absence seizures (HP:0002121)3.92370242
13Hypothermia (HP:0002045)3.92346186
14Febrile seizures (HP:0002373)3.83937002
15Neuroendocrine neoplasm (HP:0100634)3.80670702
16Acute encephalopathy (HP:0006846)3.64731274
17Epileptic encephalopathy (HP:0200134)3.56999535
18Dialeptic seizures (HP:0011146)3.56616536
19Progressive cerebellar ataxia (HP:0002073)3.51467579
20Generalized tonic-clonic seizures (HP:0002069)3.48535477
21Action tremor (HP:0002345)3.34989520
22Polyphagia (HP:0002591)3.33777912
23Hyperventilation (HP:0002883)3.31222496
24Increased CSF lactate (HP:0002490)3.27058687
25Gait imbalance (HP:0002141)3.24312290
26Failure to thrive in infancy (HP:0001531)3.17419892
27Hepatocellular necrosis (HP:0001404)3.08040388
28Abnormal hair whorl (HP:0010721)3.07923758
29Medial flaring of the eyebrow (HP:0010747)2.97597694
30Congenital primary aphakia (HP:0007707)2.96264765
31Ulnar claw (HP:0001178)2.95922391
32Chronic otitis media (HP:0000389)2.91163618
33Protruding tongue (HP:0010808)2.87386275
34Abnormal pupillary function (HP:0007686)2.86766392
35Anxiety (HP:0000739)2.82611930
36Cerebral inclusion bodies (HP:0100314)2.81633162
37Hypoglycemic coma (HP:0001325)2.80435979
38Abnormal eating behavior (HP:0100738)2.77486749
39Hemiparesis (HP:0001269)2.77076635
40Optic disc pallor (HP:0000543)2.74195518
41Nephrogenic diabetes insipidus (HP:0009806)2.73973876
42Ketoacidosis (HP:0001993)2.73368461
43Poor suck (HP:0002033)2.69765803
44Hypoventilation (HP:0002791)2.67963006
45Broad-based gait (HP:0002136)2.60978241
46Abnormal ciliary motility (HP:0012262)2.56426540
47Increased hepatocellular lipid droplets (HP:0006565)2.56345714
48Hyperinsulinemic hypoglycemia (HP:0000825)2.55596150
49Enlarged penis (HP:0000040)2.55417884
50Genital tract atresia (HP:0001827)2.53829756
51Oligodactyly (hands) (HP:0001180)2.52744003
52Vaginal atresia (HP:0000148)2.52512450
53Pancreatic cysts (HP:0001737)2.52204013
54Truncal ataxia (HP:0002078)2.47244342
55Amblyopia (HP:0000646)2.46279665
56Oligomenorrhea (HP:0000876)2.45109387
57Leukodystrophy (HP:0002415)2.44840726
58Progressive inability to walk (HP:0002505)2.41208229
59Cerebral edema (HP:0002181)2.40714443
60Postural instability (HP:0002172)2.37946652
61Hypoglycemic seizures (HP:0002173)2.37348244
62Delusions (HP:0000746)2.35340733
63Esotropia (HP:0000565)2.33275566
64Akinesia (HP:0002304)2.29577072
65Dynein arm defect of respiratory motile cilia (HP:0012255)2.26874299
66Absent/shortened dynein arms (HP:0200106)2.26874299
67Delayed gross motor development (HP:0002194)2.26532793
68Ventricular fibrillation (HP:0001663)2.25863814
69Abnormality of salivation (HP:0100755)2.25722646
70Renal Fanconi syndrome (HP:0001994)2.23954255
71Cerebral hemorrhage (HP:0001342)2.23206548
72Neurofibrillary tangles (HP:0002185)2.22884486
73Pancreatic fibrosis (HP:0100732)2.22850559
74Lipid accumulation in hepatocytes (HP:0006561)2.20276249
75Chronic sinusitis (HP:0011109)2.18228320
76Excessive salivation (HP:0003781)2.17964567
77Drooling (HP:0002307)2.17964567
78Agitation (HP:0000713)2.17861229
79Septo-optic dysplasia (HP:0100842)2.17061601
80Epileptiform EEG discharges (HP:0011182)2.16484470
81Psychosis (HP:0000709)2.14884423
82Respiratory failure (HP:0002878)2.12760338
83Exercise intolerance (HP:0003546)2.12709297
84Sensory axonal neuropathy (HP:0003390)2.11930570
85Gaze-evoked nystagmus (HP:0000640)2.11884595
86Supranuclear gaze palsy (HP:0000605)2.11741908
87Mutism (HP:0002300)2.11721833
88Inability to walk (HP:0002540)2.11510150
89Specific learning disability (HP:0001328)2.09547915
90Hypomagnesemia (HP:0002917)2.08232151
91Hepatic necrosis (HP:0002605)2.07953368
92Status epilepticus (HP:0002133)2.07407415
93Urinary urgency (HP:0000012)2.06985342
94Abnormal respiratory epithelium morphology (HP:0012253)2.06638055
95Abnormal respiratory motile cilium morphology (HP:0005938)2.06638055
96Abnormal respiratory motile cilium physiology (HP:0012261)2.03623115
97EEG with generalized epileptiform discharges (HP:0011198)2.03402840
98True hermaphroditism (HP:0010459)2.02993776
99Postural tremor (HP:0002174)2.02992623
100Poor coordination (HP:0002370)2.02750693
101Depression (HP:0000716)2.02204517
102Impaired vibration sensation in the lower limbs (HP:0002166)2.01349081
103Abnormality of the labia minora (HP:0012880)2.00534608
104Diminished movement (HP:0002374)1.97746223
105Narrow nasal bridge (HP:0000446)1.97264278
106Lactic acidosis (HP:0003128)1.97108203
107Muscular hypotonia of the trunk (HP:0008936)1.96430712
108Hypokinesia (HP:0002375)1.96263898
109Dysmetria (HP:0001310)1.95708157
110X-linked dominant inheritance (HP:0001423)1.95034677
111Papilledema (HP:0001085)1.94616197
112Abnormality of calcium-phosphate metabolism (HP:0100530)1.94371947
113Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94142247
114Increased intramyocellular lipid droplets (HP:0012240)1.93646996
115Dysdiadochokinesis (HP:0002075)1.93023402
116Spastic tetraplegia (HP:0002510)1.92752249
117Blue irides (HP:0000635)1.92323437
118Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.92199818
119Mixed hearing impairment (HP:0000410)1.90086430
120Hyperthyroidism (HP:0000836)1.89186200
121Emotional lability (HP:0000712)1.88749929
122Large for gestational age (HP:0001520)1.88409935
123Dyskinesia (HP:0100660)1.87457949
124Orthostatic hypotension (HP:0001278)1.87075139
125Fetal akinesia sequence (HP:0001989)1.86974102
126Supernumerary nipples (HP:0002558)1.86549920
127Hypsarrhythmia (HP:0002521)1.86077334
128Spastic gait (HP:0002064)1.85009834
129Pendular nystagmus (HP:0012043)1.84900665
130Neoplasm of the peripheral nervous system (HP:0100007)1.84709089
131Ketosis (HP:0001946)1.83479979
132Degeneration of the lateral corticospinal tracts (HP:0002314)1.83174547
133Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.83174547
134Morphological abnormality of the pyramidal tract (HP:0002062)1.82870961
135Diplopia (HP:0000651)1.82470207
136Abnormality of binocular vision (HP:0011514)1.82470207
137Tachypnea (HP:0002789)1.82469249
138Abnormality of the corticospinal tract (HP:0002492)1.82415563
139Ankle clonus (HP:0011448)1.82133368
140Intention tremor (HP:0002080)1.76241608
141Abnormality of the hip-girdle musculature (HP:0001445)1.74983193
142Abnormality of the musculature of the pelvis (HP:0001469)1.74983193
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.74007005
144Congenital stationary night blindness (HP:0007642)1.72751638

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K124.96882469
2PINK13.59891874
3CASK3.57874094
4FRK3.53403384
5NTRK33.39283483
6MAP3K43.28575821
7MAP2K72.86103839
8PNCK2.78224102
9MAP2K42.38515142
10MARK12.30385611
11PLK22.25033425
12ARAF2.23218780
13GRK52.19243233
14MINK12.16572837
15GRK72.08442287
16TLK12.06440908
17EPHA41.98627427
18MAP3K91.88998496
19NME11.88485459
20INSRR1.87616259
21WNK31.85433566
22NTRK21.77557044
23CDK191.73924485
24ADRBK21.64825380
25TNIK1.59017884
26MAPKAPK51.56695704
27OXSR11.51701339
28SIK31.51210202
29MAPK131.46798462
30DYRK21.42039679
31EPHA31.41877737
32MAP4K21.40474356
33NTRK11.39810911
34UHMK11.37341256
35TSSK61.36188890
36CAMK2A1.34790066
37MAPK151.33463019
38DAPK11.30253110
39FGR1.24790334
40ZAK1.21929954
41CAMK2B1.21907308
42BCR1.18831838
43AKT31.18138935
44CDK51.16962114
45DAPK21.14308177
46PRKCG1.14121728
47SIK21.09847907
48STK391.09016627
49GRK61.07983668
50WNK41.02960290
51CAMKK21.02724854
52PTK2B1.02382517
53FES1.02012584
54ADRBK11.00981127
55PASK1.00808782
56RIPK40.99681152
57CAMK2D0.96608860
58PRPF4B0.94184381
59CSNK1G20.93016594
60FGFR20.91764982
61BRAF0.91444226
62MYLK0.90606497
63DYRK1A0.86996858
64KSR10.86563608
65CSNK1G30.86117006
66KSR20.85595142
67CDK140.85291429
68TNK20.83062103
69PAK30.81922102
70BMPR20.80882118
71CDK180.80529244
72PAK60.78044549
73PRKCZ0.75314938
74CDK150.74258656
75CAMK2G0.74046718
76PRKCE0.73576329
77ERBB30.73256209
78TAOK10.67788814
79IRAK20.65797926
80MUSK0.65563301
81CDK11A0.63937727
82SGK2230.63388476
83SGK4940.63388476
84PHKG20.63255407
85PHKG10.63255407
86CDK30.62470125
87RPS6KA50.60942530
88CSNK1A10.57343906
89GRK10.56580654
90LIMK10.55190512
91CAMKK10.55067539
92STK160.54050715
93LATS20.53400109
94CAMK40.51829640
95SGK30.51376848
96ROCK20.51247981
97PRKACA0.49736451
98FER0.49646504
99MAP3K60.46700019
100MAP3K110.45294005
101CAMK10.44776273
102RAF10.44296710
103MARK30.44252433
104SGK10.43278981
105CSNK1G10.42830371
106MARK20.42586724
107PKN10.41783120
108YES10.41062849
109MAP3K130.40327692
110EPHB10.39839332
111PRKACB0.39209620
112SGK20.39059920
113MAPK120.37807005
114RPS6KA30.37266519
115BMPR1B0.37220177
116PDK10.36323531
117MAP2K10.34051211
118PRKAA10.33529512
119PRKCB0.32958542
120MST40.32127768
121STK110.31698425
122PRKCH0.31395643
123PRKCA0.31179848
124PRKG10.31077265
125CAMK1G0.30808062
126IRAK10.30658147
127PLK30.30279998
128RET0.29444901
129PRKCQ0.29289459
130DAPK30.29143845
131MAP3K10.27219267
132CSNK1E0.27105432

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.26496523
2Nicotine addiction_Homo sapiens_hsa050333.94106806
3Synaptic vesicle cycle_Homo sapiens_hsa047213.48647327
4Parkinsons disease_Homo sapiens_hsa050123.43338792
5Collecting duct acid secretion_Homo sapiens_hsa049663.41963165
6Maturity onset diabetes of the young_Homo sapiens_hsa049502.97754159
7Alzheimers disease_Homo sapiens_hsa050102.78425873
8Amphetamine addiction_Homo sapiens_hsa050312.56479939
9Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.52499057
10GABAergic synapse_Homo sapiens_hsa047272.48090250
11Huntingtons disease_Homo sapiens_hsa050162.30733866
12Vibrio cholerae infection_Homo sapiens_hsa051102.26274773
13Cocaine addiction_Homo sapiens_hsa050302.12262622
14Olfactory transduction_Homo sapiens_hsa047402.08483686
15Morphine addiction_Homo sapiens_hsa050322.06239873
16Dopaminergic synapse_Homo sapiens_hsa047282.05798481
17Serotonergic synapse_Homo sapiens_hsa047262.01102585
18Circadian entrainment_Homo sapiens_hsa047132.00819849
19Long-term potentiation_Homo sapiens_hsa047201.97347078
20Taste transduction_Homo sapiens_hsa047421.92191712
21Glutamatergic synapse_Homo sapiens_hsa047241.87508755
22Cardiac muscle contraction_Homo sapiens_hsa042601.84800736
23Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.74950931
24Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.63090041
25Long-term depression_Homo sapiens_hsa047301.61328812
26Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.59865190
27Insulin secretion_Homo sapiens_hsa049111.54938656
28Renin secretion_Homo sapiens_hsa049241.54631710
29Cholinergic synapse_Homo sapiens_hsa047251.52358430
30Salivary secretion_Homo sapiens_hsa049701.50793773
31Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.45106250
32Calcium signaling pathway_Homo sapiens_hsa040201.39271561
33Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34398748
34Gastric acid secretion_Homo sapiens_hsa049711.26378616
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.19201188
36Aldosterone synthesis and secretion_Homo sapiens_hsa049251.15159868
37Phototransduction_Homo sapiens_hsa047441.12928881
38Oxytocin signaling pathway_Homo sapiens_hsa049211.12431215
39Rheumatoid arthritis_Homo sapiens_hsa053231.11760791
40Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09471226
41Vitamin B6 metabolism_Homo sapiens_hsa007501.08818609
42Nitrogen metabolism_Homo sapiens_hsa009101.06364567
43Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01080750
44GnRH signaling pathway_Homo sapiens_hsa049120.98624778
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.98193905
46Gap junction_Homo sapiens_hsa045400.95886328
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.95210474
48Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.93846026
49Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.93082130
50Protein export_Homo sapiens_hsa030600.85508426
51Tyrosine metabolism_Homo sapiens_hsa003500.80373368
52Proteasome_Homo sapiens_hsa030500.80358425
53Phagosome_Homo sapiens_hsa041450.80333066
54Linoleic acid metabolism_Homo sapiens_hsa005910.80019330
55Phenylalanine metabolism_Homo sapiens_hsa003600.77932108
56alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75611446
57Circadian rhythm_Homo sapiens_hsa047100.73831100
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.71993360
59cAMP signaling pathway_Homo sapiens_hsa040240.70779541
60Type I diabetes mellitus_Homo sapiens_hsa049400.70570635
61Axon guidance_Homo sapiens_hsa043600.69001121
62Estrogen signaling pathway_Homo sapiens_hsa049150.68406511
63Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67292051
64Folate biosynthesis_Homo sapiens_hsa007900.66831572
65Pyruvate metabolism_Homo sapiens_hsa006200.62237881
66Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.61176109
67Melanogenesis_Homo sapiens_hsa049160.60525469
68Alcoholism_Homo sapiens_hsa050340.59570598
69Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.59114069
70Tryptophan metabolism_Homo sapiens_hsa003800.58680391
71Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.57092327
72Fatty acid biosynthesis_Homo sapiens_hsa000610.54903523
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.54201936
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53994106
75Mineral absorption_Homo sapiens_hsa049780.53605042
76Pancreatic secretion_Homo sapiens_hsa049720.53027274
77Thyroid hormone synthesis_Homo sapiens_hsa049180.51913045
78Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50073617
79Prion diseases_Homo sapiens_hsa050200.49593764
80Fatty acid elongation_Homo sapiens_hsa000620.49545718
81Peroxisome_Homo sapiens_hsa041460.49403762
82Glucagon signaling pathway_Homo sapiens_hsa049220.49143156
83Butanoate metabolism_Homo sapiens_hsa006500.47718953
84ErbB signaling pathway_Homo sapiens_hsa040120.47442397
85Propanoate metabolism_Homo sapiens_hsa006400.47289617
86cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46525084
87Steroid hormone biosynthesis_Homo sapiens_hsa001400.45709699
88Type II diabetes mellitus_Homo sapiens_hsa049300.44019605
89Oocyte meiosis_Homo sapiens_hsa041140.43121896
90Sulfur relay system_Homo sapiens_hsa041220.42900518
91Ether lipid metabolism_Homo sapiens_hsa005650.42019702
92Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.41789069
93African trypanosomiasis_Homo sapiens_hsa051430.41618705
94ABC transporters_Homo sapiens_hsa020100.41597887
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.37148699
96Dilated cardiomyopathy_Homo sapiens_hsa054140.36621673
97SNARE interactions in vesicular transport_Homo sapiens_hsa041300.35818334
98Regulation of autophagy_Homo sapiens_hsa041400.34086881
99Histidine metabolism_Homo sapiens_hsa003400.32325203
100Bile secretion_Homo sapiens_hsa049760.31444446
101MAPK signaling pathway_Homo sapiens_hsa040100.30901222
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.30631781
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.28857674
104beta-Alanine metabolism_Homo sapiens_hsa004100.28140836
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.27644758
106Basal transcription factors_Homo sapiens_hsa030220.27037239
107Sulfur metabolism_Homo sapiens_hsa009200.26416661
108AMPK signaling pathway_Homo sapiens_hsa041520.25667777
109Starch and sucrose metabolism_Homo sapiens_hsa005000.25404709
110Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.24995304
111Ras signaling pathway_Homo sapiens_hsa040140.24920023
112Dorso-ventral axis formation_Homo sapiens_hsa043200.24660007
113Metabolic pathways_Homo sapiens_hsa011000.22755812
114Glioma_Homo sapiens_hsa052140.22096049
115Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.21943602
116Ovarian steroidogenesis_Homo sapiens_hsa049130.21075442
117Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20123828
118Inositol phosphate metabolism_Homo sapiens_hsa005620.20040895
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.19241805
120Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.16260727
121Choline metabolism in cancer_Homo sapiens_hsa052310.16079531
122Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.15934544
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.13001600
124Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.12378661
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.11206112

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