CTXN3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1dopamine transport (GO:0015872)9.53655246
2sensory perception of chemical stimulus (GO:0007606)9.17374228
3dopamine biosynthetic process (GO:0042416)8.81256948
4protein insertion into membrane (GO:0051205)8.07611452
5catecholamine transport (GO:0051937)7.22871540
6protein polyglutamylation (GO:0018095)6.88982305
7phenol-containing compound catabolic process (GO:0019336)6.67008752
8prepulse inhibition (GO:0060134)6.58228505
9protein localization to cilium (GO:0061512)6.28670610
10adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)6.07827183
11synaptic vesicle maturation (GO:0016188)6.02991589
12neurotransmitter biosynthetic process (GO:0042136)5.73659859
13mating behavior (GO:0007617)5.56921297
14synaptic vesicle exocytosis (GO:0016079)5.51926897
15catechol-containing compound biosynthetic process (GO:0009713)5.39842202
16catecholamine biosynthetic process (GO:0042423)5.39842202
17regulation of catecholamine metabolic process (GO:0042069)5.27437600
18regulation of dopamine metabolic process (GO:0042053)5.27437600
19regulation of short-term neuronal synaptic plasticity (GO:0048172)5.25387636
20membrane depolarization during cardiac muscle cell action potential (GO:0086012)5.22487245
21neuronal action potential (GO:0019228)5.02666628
22regulation of cilium movement (GO:0003352)4.99406280
23response to insecticide (GO:0017085)4.98926690
24cellular response to nicotine (GO:0071316)4.97567958
25regulation of synaptic vesicle transport (GO:1902803)4.97489658
26neurotransmitter transport (GO:0006836)4.84892820
27neurotransmitter secretion (GO:0007269)4.80321521
28regulation of cell communication by electrical coupling (GO:0010649)4.79278469
29response to manganese ion (GO:0010042)4.71719692
30dopamine receptor signaling pathway (GO:0007212)4.69667617
31dopamine metabolic process (GO:0042417)4.57345840
32monoamine transport (GO:0015844)4.53559837
33regulation of neurotransmitter levels (GO:0001505)4.46547821
34neuronal action potential propagation (GO:0019227)4.44501642
35response to cocaine (GO:0042220)4.39735308
36positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.39559047
37regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)4.33436680
38negative regulation of complement activation (GO:0045916)4.32095120
39regulation of female gonad development (GO:2000194)4.24492934
40positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.23285329
41synaptic transmission, dopaminergic (GO:0001963)4.23164050
42sequestering of actin monomers (GO:0042989)4.18872431
43detection of calcium ion (GO:0005513)4.17397834
44membrane depolarization during action potential (GO:0086010)4.16931249
45neurotransmitter metabolic process (GO:0042133)4.12170439
46regulation of long-term neuronal synaptic plasticity (GO:0048169)4.04593329
47regulation of neuronal synaptic plasticity (GO:0048168)4.03567085
48response to amphetamine (GO:0001975)4.02974055
49phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.98001994
50activation of protein kinase A activity (GO:0034199)3.94244606
51axoneme assembly (GO:0035082)3.94107279
52sodium ion export (GO:0071436)3.93232159
53positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.82916423
54neuron-neuron synaptic transmission (GO:0007270)3.82662152
55negative regulation of cation channel activity (GO:2001258)3.82352461
56behavioral response to cocaine (GO:0048148)3.82009959
57behavioral response to pain (GO:0048266)3.81657644
58negative regulation of neurotransmitter transport (GO:0051589)3.79760774
59exploration behavior (GO:0035640)3.78862401
60response to water (GO:0009415)3.77307264
61regulation of chromatin binding (GO:0035561)3.74208370
62cilium morphogenesis (GO:0060271)3.73942933
63regulation of synapse structural plasticity (GO:0051823)3.73168178
64negative regulation of dendrite morphogenesis (GO:0050774)3.72770960
65negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.71272934
66sarcoplasmic reticulum calcium ion transport (GO:0070296)3.70985599
67protein localization to synapse (GO:0035418)3.65911312
68neuron cell-cell adhesion (GO:0007158)3.65814168
69locomotory exploration behavior (GO:0035641)3.65619423
70positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.64478547
71calcium-mediated signaling using intracellular calcium source (GO:0035584)3.64056928
72negative regulation of cytosolic calcium ion concentration (GO:0051481)3.62200690
73regulation of sodium ion transmembrane transporter activity (GO:2000649)3.60259230
74negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.56704313
75peristalsis (GO:0030432)3.55769145
76negative regulation of protein activation cascade (GO:2000258)3.55473848
77synaptic vesicle endocytosis (GO:0048488)3.51280963
78negative regulation of microtubule polymerization (GO:0031115)3.49447079
79regulation of neurotransmitter transport (GO:0051588)3.49092849
80ionotropic glutamate receptor signaling pathway (GO:0035235)3.48714956
81glutamate secretion (GO:0014047)3.48375129
82positive regulation of synapse maturation (GO:0090129)3.48280280
83microtubule severing (GO:0051013)3.46716872
84regulation of vesicle fusion (GO:0031338)3.45476402
85urinary tract smooth muscle contraction (GO:0014848)3.43520716
86plasma membrane repair (GO:0001778)3.43339639
87potassium ion export (GO:0071435)3.42945077
88cellular response to glucagon stimulus (GO:0071377)3.42887509
89negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.41636555
90response to nicotine (GO:0035094)3.38352644
91synaptic transmission, glutamatergic (GO:0035249)3.38122890
92regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.36974287
93bundle of His cell to Purkinje myocyte communication (GO:0086069)3.30961274
94cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.30609312
95regulation of neurotransmitter secretion (GO:0046928)3.29621180
96regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.28089787
97regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.26929714
98negative regulation of sodium ion transport (GO:0010766)3.26591418
99regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.26086849
100cellular potassium ion transport (GO:0071804)3.25029177
101potassium ion transmembrane transport (GO:0071805)3.25029177
102gamma-aminobutyric acid signaling pathway (GO:0007214)3.22592356
103regulation of microtubule-based movement (GO:0060632)3.22256049
104neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.22112104
105positive regulation of neurotransmitter transport (GO:0051590)3.21416249
106response to corticosterone (GO:0051412)3.20162228
107regulation of protein kinase A signaling (GO:0010738)3.19282727
108neurotransmitter uptake (GO:0001504)3.19017159
109L-amino acid import (GO:0043092)3.18114549
110phenol-containing compound biosynthetic process (GO:0046189)3.16655120
111microtubule bundle formation (GO:0001578)3.16500580
112regulation of voltage-gated calcium channel activity (GO:1901385)3.16253991
113cell migration in hindbrain (GO:0021535)3.15454613
114negative regulation of calcium ion transmembrane transport (GO:1903170)3.12464035
115negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.12464035
116alkaloid metabolic process (GO:0009820)3.11984481
117auditory behavior (GO:0031223)3.11044522
118establishment of synaptic vesicle localization (GO:0097480)3.10778917
119synaptic vesicle transport (GO:0048489)3.10778917
120intraciliary transport (GO:0042073)3.10773231
121regulation of sodium ion transmembrane transport (GO:1902305)3.09223725
122intraspecies interaction between organisms (GO:0051703)3.07791307
123social behavior (GO:0035176)3.07791307
124regulation of synaptic plasticity (GO:0048167)3.07610718
125negative regulation of synaptic transmission, GABAergic (GO:0032229)3.07415807
126cerebellar granule cell differentiation (GO:0021707)3.07040878
127regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.05782343
128glutamate receptor signaling pathway (GO:0007215)3.05650159
129potassium ion import (GO:0010107)3.03666445
130regulation of excitatory postsynaptic membrane potential (GO:0060079)3.03117913
131sensory perception of taste (GO:0050909)3.02354258
132positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.00330495
133negative regulation of humoral immune response (GO:0002921)3.00262420
134regulation of heart rate by cardiac conduction (GO:0086091)3.00123114
135membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.99546890
136response to pain (GO:0048265)2.99492240
137potassium ion transport (GO:0006813)2.99268007
138regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.98954957
139vocalization behavior (GO:0071625)2.98695468
140cellular potassium ion homeostasis (GO:0030007)2.98359075
141postsynaptic membrane organization (GO:0001941)2.98031056
142membrane repolarization (GO:0086009)2.97791671
143adenosine metabolic process (GO:0046085)2.97566061
144response to ammonium ion (GO:0060359)2.97307553
145membrane depolarization (GO:0051899)2.96584831
146positive regulation of neurotransmitter secretion (GO:0001956)2.96002796
147melanosome transport (GO:0032402)2.94900498
148detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.94870681
149detection of temperature stimulus involved in sensory perception (GO:0050961)2.94870681
150vesicle transport along microtubule (GO:0047496)2.94824499
151action potential (GO:0001508)2.90698354
152synaptic vesicle docking involved in exocytosis (GO:0016081)2.90564781
153regulation of postsynaptic membrane potential (GO:0060078)2.90255082
154skeletal muscle fiber development (GO:0048741)2.89859434
155regulation of glutamate receptor signaling pathway (GO:1900449)2.89589814
156response to mineralocorticoid (GO:0051385)2.89324311
157synaptic transmission (GO:0007268)2.89111517
158positive regulation of vesicle fusion (GO:0031340)2.88953490
159regulation of clathrin-mediated endocytosis (GO:2000369)2.87588809
160catecholamine metabolic process (GO:0006584)2.87451556
161catechol-containing compound metabolic process (GO:0009712)2.87451556
162neurofilament cytoskeleton organization (GO:0060052)2.86198091
163cellular response to prostaglandin stimulus (GO:0071379)2.86195292
164positive regulation of muscle hypertrophy (GO:0014742)2.85189162
165positive regulation of cardiac muscle hypertrophy (GO:0010613)2.85189162
166cell communication involved in cardiac conduction (GO:0086065)2.84740015
167glycogen catabolic process (GO:0005980)2.84330681
168response to caffeine (GO:0031000)2.83500612
169melanosome localization (GO:0032400)2.82310256
170negative regulation of ion transmembrane transporter activity (GO:0032413)2.80893104
171regulation of membrane repolarization (GO:0060306)2.78885269
172regulation of dopamine secretion (GO:0014059)2.78383411
173establishment of melanosome localization (GO:0032401)2.77777341
174pigment granule transport (GO:0051904)2.77362791
175regulation of synaptic vesicle exocytosis (GO:2000300)2.76066572
176brain morphogenesis (GO:0048854)2.71428115
177peripheral nervous system neuron development (GO:0048935)2.69576783
178acrosome reaction (GO:0007340)2.68654180
179regulation of cation channel activity (GO:2001257)2.68412396
180neuromuscular synaptic transmission (GO:0007274)2.68052746
181calcium ion-dependent exocytosis (GO:0017156)2.67496995
182pigment granule localization (GO:0051875)2.67489356
183striatum development (GO:0021756)2.65379103
184sensory perception of smell (GO:0007608)14.8068272

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.53865383
2ZNF263_19887448_ChIP-Seq_K562_Human3.66518230
3TAF15_26573619_Chip-Seq_HEK293_Human3.19630764
4GBX2_23144817_ChIP-Seq_PC3_Human2.95775420
5RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90133161
6VDR_22108803_ChIP-Seq_LS180_Human2.66576812
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.56724693
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52874610
9ESR1_20079471_ChIP-ChIP_T-47D_Human2.32519253
10DROSHA_22980978_ChIP-Seq_HELA_Human2.23333690
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.22489574
12RNF2_18974828_ChIP-Seq_MESCs_Mouse2.12576121
13EZH2_18974828_ChIP-Seq_MESCs_Mouse2.12576121
14EED_16625203_ChIP-ChIP_MESCs_Mouse2.07680613
15SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.05944358
16SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01545999
17JARID2_20064375_ChIP-Seq_MESCs_Mouse1.93037711
18SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.90333248
19BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.87672111
20REST_21632747_ChIP-Seq_MESCs_Mouse1.86395163
21SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.85557570
22ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.84907212
23JARID2_20075857_ChIP-Seq_MESCs_Mouse1.84472356
24MTF2_20144788_ChIP-Seq_MESCs_Mouse1.81988714
25MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.80642963
26BMI1_23680149_ChIP-Seq_NPCS_Mouse1.77162319
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.76451175
28CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.75038046
29CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74684086
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.71024609
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.66713532
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.66088497
33SRY_22984422_ChIP-ChIP_TESTIS_Rat1.65963469
34AHR_22903824_ChIP-Seq_MCF-7_Human1.65327460
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60323786
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60198411
37NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.58924039
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.53508256
39SMAD4_21799915_ChIP-Seq_A2780_Human1.53032786
40TOP2B_26459242_ChIP-Seq_MCF-7_Human1.52183385
41AR_21572438_ChIP-Seq_LNCaP_Human1.51383543
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.50718124
43CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50044348
44RARB_27405468_Chip-Seq_BRAIN_Mouse1.49183307
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.48546628
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.45569956
47BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.44417577
48CBX2_27304074_Chip-Seq_ESCs_Mouse1.39148941
49OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35972961
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.34064736
51PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.32539253
52REST_18959480_ChIP-ChIP_MESCs_Mouse1.32347336
53KDM2B_26808549_Chip-Seq_K562_Human1.32245315
54IKZF1_21737484_ChIP-ChIP_HCT116_Human1.31574645
55THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.30654373
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27394535
57P300_19829295_ChIP-Seq_ESCs_Human1.25061685
58PRDM14_20953172_ChIP-Seq_ESCs_Human1.24642013
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.23041977
60ESR2_21235772_ChIP-Seq_MCF-7_Human1.21965612
61ARNT_22903824_ChIP-Seq_MCF-7_Human1.21265381
62FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.21241397
63ERG_21242973_ChIP-ChIP_JURKAT_Human1.20935429
64RNF2_27304074_Chip-Seq_NSC_Mouse1.20860471
65DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20727237
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17968619
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.16223471
68* SMAD4_21741376_ChIP-Seq_EPCs_Human1.16183363
69CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.15374580
70GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.14381281
71ZFP57_27257070_Chip-Seq_ESCs_Mouse1.13070629
72IGF1R_20145208_ChIP-Seq_DFB_Human1.12837616
73POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12719554
74TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12719554
75ETV2_25802403_ChIP-Seq_MESCs_Mouse1.10565949
76ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07502750
77OCT4_20526341_ChIP-Seq_ESCs_Human1.07308928
78PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.07247623
79TET1_21490601_ChIP-Seq_MESCs_Mouse1.06555183
80RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05220399
81CTBP1_25329375_ChIP-Seq_LNCAP_Human1.04621520
82* AR_19668381_ChIP-Seq_PC3_Human1.04601151
83ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04272809
84* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.03337147
85* STAT3_23295773_ChIP-Seq_U87_Human1.03099487
86WT1_19549856_ChIP-ChIP_CCG9911_Human1.02640564
87* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.01659355
88ER_23166858_ChIP-Seq_MCF-7_Human1.01294446
89TCF4_23295773_ChIP-Seq_U87_Human1.00704501
90BCAT_22108803_ChIP-Seq_LS180_Human1.00291577
91NR3C1_21868756_ChIP-Seq_MCF10A_Human0.99509943
92PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.99330974
93* SMAD4_21741376_ChIP-Seq_HESCs_Human0.98967223
94CTCF_27219007_Chip-Seq_Bcells_Human0.98029686
95GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.98013638
96YY1_22570637_ChIP-Seq_MALME-3M_Human0.96467674
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96397843
98SMAD3_21741376_ChIP-Seq_EPCs_Human0.96302918
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95722750
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95679435
101P53_22127205_ChIP-Seq_FIBROBLAST_Human0.95373461
102UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.95102849
103SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.95093427
104RING1B_27294783_Chip-Seq_NPCs_Mouse0.94511885
105TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.94409493
106PIAS1_25552417_ChIP-Seq_VCAP_Human0.94249425
107RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93498482
108OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.92770536
109ZNF217_24962896_ChIP-Seq_MCF-7_Human0.92388487
110YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91555156
111DPY_21335234_ChIP-Seq_ESCs_Mouse0.91193010
112TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91036973
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90715446
114TAF2_19829295_ChIP-Seq_ESCs_Human0.90657682
115SOX2_21211035_ChIP-Seq_LN229_Gbm0.89121661
116JUN_21703547_ChIP-Seq_K562_Human0.88650278
117* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.87246653
118RING1B_27294783_Chip-Seq_ESCs_Mouse0.86904769
119MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85950248
120EP300_21415370_ChIP-Seq_HL-1_Mouse0.85914884
121CTNNB1_20460455_ChIP-Seq_HCT116_Human0.85025286
122NANOG_20526341_ChIP-Seq_ESCs_Human0.84664803
123TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.83951190
124EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.83617183
125TDRD3_21172665_ChIP-Seq_MCF-7_Human0.83519177
126OCT4_19829295_ChIP-Seq_ESCs_Human0.83039203
127SMAD3_21741376_ChIP-Seq_ESCs_Human0.83005221
128SOX2_19829295_ChIP-Seq_ESCs_Human0.82787485
129NANOG_19829295_ChIP-Seq_ESCs_Human0.82787485
130RUNX2_22187159_ChIP-Seq_PCA_Human0.82638969
131NCOR_22424771_ChIP-Seq_293T_Human0.82434226
132* AR_25329375_ChIP-Seq_VCAP_Human0.82225470
133SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81097236
134MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.80913227
135BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77810520
136KDM2B_26808549_Chip-Seq_REH_Human0.77622425
137FLI1_21867929_ChIP-Seq_TH2_Mouse0.77169063
138TP53_20018659_ChIP-ChIP_R1E_Mouse0.76746509

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001968_abnormal_touch/_nociception4.17454495
2MP0002735_abnormal_chemical_nociception4.09106486
3MP0002736_abnormal_nociception_after4.05715488
4MP0002734_abnormal_mechanical_nocicepti3.46761444
5MP0004270_analgesia3.05119652
6MP0008789_abnormal_olfactory_epithelium3.05083771
7MP0005499_abnormal_olfactory_system2.69889222
8MP0005394_taste/olfaction_phenotype2.69889222
9MP0001986_abnormal_taste_sensitivity2.55137352
10MP0002184_abnormal_innervation2.50923462
11MP0001970_abnormal_pain_threshold2.48557661
12MP0002733_abnormal_thermal_nociception2.44870414
13MP0004145_abnormal_muscle_electrophysio2.40802272
14MP0003806_abnormal_nucleotide_metabolis2.19895858
15MP0001501_abnormal_sleep_pattern2.18595095
16MP0003880_abnormal_central_pattern2.15847662
17MP0006276_abnormal_autonomic_nervous2.12058281
18MP0002272_abnormal_nervous_system2.06876885
19MP0004858_abnormal_nervous_system2.01163332
20MP0001984_abnormal_olfaction11.5266611
21MP0002822_catalepsy1.88624943
22MP0005645_abnormal_hypothalamus_physiol1.85057632
23MP0008872_abnormal_physiological_respon1.80537884
24MP0004859_abnormal_synaptic_plasticity1.67908579
25MP0003635_abnormal_synaptic_transmissio1.65885524
26MP0001188_hyperpigmentation1.63055767
27MP0000372_irregular_coat_pigmentation1.58950372
28MP0003329_amyloid_beta_deposits1.56773016
29MP0002067_abnormal_sensory_capabilities1.49214626
30MP0001177_atelectasis1.48354094
31MP0002160_abnormal_reproductive_system1.36708352
32MP0002653_abnormal_ependyma_morphology1.34557923
33MP0002837_dystrophic_cardiac_calcinosis1.31671071
34MP0004811_abnormal_neuron_physiology1.31420553
35MP0000749_muscle_degeneration1.29500616
36MP0002064_seizures1.23329441
37MP0000569_abnormal_digit_pigmentation1.20710777
38MP0002557_abnormal_social/conspecific_i1.19415458
39MP0002063_abnormal_learning/memory/cond1.18350787
40MP0002909_abnormal_adrenal_gland1.18331600
41MP0003656_abnormal_erythrocyte_physiolo1.17842971
42MP0002332_abnormal_exercise_endurance1.15833862
43MP0000751_myopathy1.15005343
44MP0002882_abnormal_neuron_morphology1.14008778
45MP0004043_abnormal_pH_regulation1.12948975
46MP0001502_abnormal_circadian_rhythm1.11689718
47MP0002752_abnormal_somatic_nervous1.11519662
48MP0003690_abnormal_glial_cell1.10091348
49MP0003646_muscle_fatigue1.09146641
50MP0002638_abnormal_pupillary_reflex1.07469886
51MP0002928_abnormal_bile_duct1.07404021
52MP0000747_muscle_weakness1.06730279
53MP0009046_muscle_twitch1.05733021
54MP0005646_abnormal_pituitary_gland1.05619469
55MP0004036_abnormal_muscle_relaxation1.04876708
56MP0010234_abnormal_vibrissa_follicle1.04492031
57MP0000631_abnormal_neuroendocrine_gland1.02998532
58MP0009745_abnormal_behavioral_response1.02934328
59MP0004885_abnormal_endolymph1.01190132
60MP0005084_abnormal_gallbladder_morpholo1.01016293
61MP0005423_abnormal_somatic_nervous0.99884933
62MP0001486_abnormal_startle_reflex0.99556391
63MP0001270_distended_abdomen0.98921056
64MP0004233_abnormal_muscle_weight0.98822605
65MP0002572_abnormal_emotion/affect_behav0.97592386
66MP0005535_abnormal_body_temperature0.97479086
67MP0009780_abnormal_chondrocyte_physiolo0.96923590
68MP0001542_abnormal_bone_strength0.96503449
69MP0003787_abnormal_imprinting0.94360723
70MP0003632_abnormal_nervous_system0.93925793
71MP0000778_abnormal_nervous_system0.93022850
72MP0006036_abnormal_mitochondrial_physio0.91149014
73MP0008874_decreased_physiological_sensi0.87909946
74MP0005367_renal/urinary_system_phenotyp0.87659419
75MP0000516_abnormal_urinary_system0.87659419
76MP0001485_abnormal_pinna_reflex0.87172055
77MP0004084_abnormal_cardiac_muscle0.87050416
78MP0003633_abnormal_nervous_system0.86073442
79MP0005409_darkened_coat_color0.85946130
80MP0005377_hearing/vestibular/ear_phenot0.85666647
81MP0003878_abnormal_ear_physiology0.85666647
82MP0001963_abnormal_hearing_physiology0.83179360
83MP0005410_abnormal_fertilization0.81979470
84MP0000920_abnormal_myelination0.80864552
85MP0000538_abnormal_urinary_bladder0.80040618
86MP0000955_abnormal_spinal_cord0.79829966
87MP0002751_abnormal_autonomic_nervous0.79134849
88MP0004130_abnormal_muscle_cell0.78954903
89MP0000750_abnormal_muscle_regeneration0.76788280
90MP0003634_abnormal_glial_cell0.74484115
91MP0002229_neurodegeneration0.74201261
92MP0004142_abnormal_muscle_tone0.70736606
93MP0002876_abnormal_thyroid_physiology0.70625887
94MP0005551_abnormal_eye_electrophysiolog0.70210190
95MP0002066_abnormal_motor_capabilities/c0.69103256
96MP0002106_abnormal_muscle_physiology0.68152873
97MP0003879_abnormal_hair_cell0.67994081
98MP0000759_abnormal_skeletal_muscle0.67906391
99MP0001943_abnormal_respiration0.65746202
100MP0001529_abnormal_vocalization0.65639330
101MP0000013_abnormal_adipose_tissue0.64406475
102MP0001905_abnormal_dopamine_level0.64130393
103MP0001299_abnormal_eye_distance/0.64078673
104MP0003137_abnormal_impulse_conducting0.63944341
105MP0003693_abnormal_embryo_hatching0.62327738
106MP0005620_abnormal_muscle_contractility0.61948204
107MP0004087_abnormal_muscle_fiber0.60958882
108MP0002972_abnormal_cardiac_muscle0.60562899
109MP0004484_altered_response_of0.60498976
110MP0005584_abnormal_enzyme/coenzyme_acti0.60101526
111MP0002152_abnormal_brain_morphology0.59944248
112MP0005187_abnormal_penis_morphology0.59235315
113MP0006035_abnormal_mitochondrial_morpho0.58602963
114MP0004924_abnormal_behavior0.58503161
115MP0005386_behavior/neurological_phenoty0.58503161
116MP0004085_abnormal_heartbeat0.58300724
117MP0002069_abnormal_eating/drinking_beha0.58185823
118MP0001440_abnormal_grooming_behavior0.57953326
119MP0003631_nervous_system_phenotype0.57414034
120MP0004510_myositis0.56725885
121MP0003122_maternal_imprinting0.56682473
122MP0004147_increased_porphyrin_level0.55512541
123MP0010386_abnormal_urinary_bladder0.55135282
124MP0000604_amyloidosis0.55038112
125MP0002877_abnormal_melanocyte_morpholog0.55013530
126MP0001664_abnormal_digestion0.54598901
127MP0005369_muscle_phenotype0.54132891
128MP0008569_lethality_at_weaning0.53848397
129MP0002269_muscular_atrophy0.53201226
130MP0005389_reproductive_system_phenotype0.52586935
131MP0003075_altered_response_to0.51963479
132MP0004215_abnormal_myocardial_fiber0.50682038
133MP0004742_abnormal_vestibular_system0.50555085

Predicted human phenotypes

RankGene SetZ-score
1Retinal dysplasia (HP:0007973)6.39487296
2Parkinsonism with favorable response to dopaminergic medication (HP:0002548)6.18826240
3Hypokinesia (HP:0002375)5.45214816
4Postural instability (HP:0002172)5.18343599
5Limb dystonia (HP:0002451)5.12289665
6Myokymia (HP:0002411)4.79338403
7Hypothermia (HP:0002045)4.72619477
8Atonic seizures (HP:0010819)4.67870031
9Akinesia (HP:0002304)4.47412202
10Rigidity (HP:0002063)4.35730262
11Palpitations (HP:0001962)4.34081015
12Diminished movement (HP:0002374)4.31003891
13Myotonia (HP:0002486)4.30832202
14Bradykinesia (HP:0002067)4.19593661
15Bifid tongue (HP:0010297)4.17235404
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.12519938
17Abnormality of macular pigmentation (HP:0008002)4.05525734
18Abnormality of binocular vision (HP:0011514)4.01369766
19Diplopia (HP:0000651)4.01369766
20Distal arthrogryposis (HP:0005684)3.96535563
21Impaired pain sensation (HP:0007328)3.78728443
22Abnormality of pain sensation (HP:0010832)3.78728443
23Torticollis (HP:0000473)3.71702033
24Febrile seizures (HP:0002373)3.65571159
25Dyskinesia (HP:0100660)3.58305170
26Delayed gross motor development (HP:0002194)3.56135076
27Dysautonomia (HP:0002459)3.51986273
28Dysphonia (HP:0001618)3.51474230
29Abnormal respiratory motile cilium physiology (HP:0012261)3.50952568
30Molar tooth sign on MRI (HP:0002419)3.40483639
31Abnormality of midbrain morphology (HP:0002418)3.40483639
32Absence seizures (HP:0002121)3.36489474
33Mask-like facies (HP:0000298)3.34244739
34Focal seizures (HP:0007359)3.33597249
35Craniofacial dystonia (HP:0012179)3.27677293
36Gait imbalance (HP:0002141)3.22805071
37Muscle fiber inclusion bodies (HP:0100299)3.20680696
38Morphological abnormality of the pyramidal tract (HP:0002062)3.15200893
39Abnormal ciliary motility (HP:0012262)3.15158686
40Congenital primary aphakia (HP:0007707)3.10150880
41Dialeptic seizures (HP:0011146)3.09761044
42Focal dystonia (HP:0004373)3.06676175
43Sudden death (HP:0001699)3.02856023
44Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)3.00898649
45Rhinitis (HP:0012384)2.99868119
46Nephrogenic diabetes insipidus (HP:0009806)2.98418252
47Anosmia (HP:0000458)2.96329575
48Pheochromocytoma (HP:0002666)2.92186758
49Medial flaring of the eyebrow (HP:0010747)2.89733230
50Termporal pattern (HP:0011008)2.86723565
51Insidious onset (HP:0003587)2.86723565
52Abolished electroretinogram (ERG) (HP:0000550)2.83374876
53Rapidly progressive (HP:0003678)2.82717759
54Neuroendocrine neoplasm (HP:0100634)2.79704695
55Genital tract atresia (HP:0001827)2.77687519
56Vaginal atresia (HP:0000148)2.77295870
57Syncope (HP:0001279)2.76914337
58Abnormal respiratory epithelium morphology (HP:0012253)2.75419380
59Abnormal respiratory motile cilium morphology (HP:0005938)2.75419380
60Exercise-induced myalgia (HP:0003738)2.75400925
61Fetal akinesia sequence (HP:0001989)2.68933985
62Bradycardia (HP:0001662)2.66950734
63Nemaline bodies (HP:0003798)2.66573021
64Muscle stiffness (HP:0003552)2.62009090
65Foot dorsiflexor weakness (HP:0009027)2.55228128
66Status epilepticus (HP:0002133)2.54587214
67Muscle hypertrophy of the lower extremities (HP:0008968)2.51790763
68Progressive macrocephaly (HP:0004481)2.51542395
69Acute necrotizing encephalopathy (HP:0006965)2.48755247
70Difficulty running (HP:0009046)2.48591773
71Poor eye contact (HP:0000817)2.48502459
72Hyporeflexia of lower limbs (HP:0002600)2.48358034
73Progressive cerebellar ataxia (HP:0002073)2.46313666
74Increased circulating renin level (HP:0000848)2.46014002
75Muscle fiber splitting (HP:0003555)2.45633521
76Slow saccadic eye movements (HP:0000514)2.45589218
77Truncal ataxia (HP:0002078)2.44042884
78Generalized tonic-clonic seizures (HP:0002069)2.43669716
79Abnormal eating behavior (HP:0100738)2.39113687
80Bony spicule pigmentary retinopathy (HP:0007737)2.38855386
81Abnormality of saccadic eye movements (HP:0000570)2.38350232
82Ankle clonus (HP:0011448)2.36354484
83Poor coordination (HP:0002370)2.36269098
84Acute encephalopathy (HP:0006846)2.36009190
85Visual hallucinations (HP:0002367)2.35759103
86Action tremor (HP:0002345)2.34855046
87Neurofibrillary tangles (HP:0002185)2.31965404
88Hemiplegia (HP:0002301)2.30454108
89Abnormality of the foot musculature (HP:0001436)2.30301867
90Abnormal mitochondria in muscle tissue (HP:0008316)2.30167435
91Bundle branch block (HP:0011710)2.30106995
92Areflexia of lower limbs (HP:0002522)2.30101407
93Type 1 muscle fiber predominance (HP:0003803)2.29039297
94Muscular hypotonia of the trunk (HP:0008936)2.29024082
95Focal motor seizures (HP:0011153)2.28669597
96Mutism (HP:0002300)2.28557516
97Failure to thrive in infancy (HP:0001531)2.27982044
98Cerebral inclusion bodies (HP:0100314)2.27370316
99Postaxial hand polydactyly (HP:0001162)2.24997519
100Absent phalangeal crease (HP:0006109)2.23629633
101Calf muscle hypertrophy (HP:0008981)2.22444508
102Central scotoma (HP:0000603)2.19924043
103Hemiparesis (HP:0001269)2.19160082
104Neuronal loss in central nervous system (HP:0002529)2.19109751
105Round ear (HP:0100830)2.18252496
106Myoglobinuria (HP:0002913)2.14679910
107Pancreatic fibrosis (HP:0100732)2.11192581
108Depression (HP:0000716)2.09796572
109Renal hypoplasia (HP:0000089)2.07662725
110Myoclonus (HP:0001336)2.07113186
111Abnormality of the calf musculature (HP:0001430)2.06793293
112Spastic gait (HP:0002064)2.06422585
113Impaired vibration sensation in the lower limbs (HP:0002166)2.05273202
114Delusions (HP:0000746)2.04700568
115Chronic bronchitis (HP:0004469)2.04426400
116Cerebral hypomyelination (HP:0006808)2.02128750
117Neonatal onset (HP:0003623)2.01870709
118Myopathic facies (HP:0002058)2.01699308
119Sensory axonal neuropathy (HP:0003390)2.01371327
120Papilledema (HP:0001085)2.01172406
121Epileptiform EEG discharges (HP:0011182)1.99970980
122Hyperglycinemia (HP:0002154)1.98260947
123Exercise-induced muscle cramps (HP:0003710)1.96681360
124Lower limb muscle weakness (HP:0007340)1.95407741
125Prolonged QT interval (HP:0001657)1.95333726
126Dysmetria (HP:0001310)1.95084910
127EMG: neuropathic changes (HP:0003445)1.94040979
128Tetraplegia (HP:0002445)1.93139773
129Impaired social interactions (HP:0000735)1.93057303
130Abnormal social behavior (HP:0012433)1.93057303
131Left ventricular hypertrophy (HP:0001712)1.90502641
132Conjunctival hamartoma (HP:0100780)1.90134999
133Rhabdomyolysis (HP:0003201)1.89617672
134Ulnar claw (HP:0001178)1.88630324
135True hermaphroditism (HP:0010459)1.88560720
136Epileptic encephalopathy (HP:0200134)1.88307960
137Urinary bladder sphincter dysfunction (HP:0002839)1.87609770
138Ulnar deviation of the wrist (HP:0003049)1.86965144
139Amblyopia (HP:0000646)1.84384224
140Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.84049100
141Metabolic alkalosis (HP:0200114)1.83669684
142Centrally nucleated skeletal muscle fibers (HP:0003687)1.83073865
143Frequent falls (HP:0002359)1.81832360
144Ventricular fibrillation (HP:0001663)1.79919033
145Mitochondrial inheritance (HP:0001427)1.79101470
146Asymmetric septal hypertrophy (HP:0001670)1.77601451
147Abnormality of skeletal muscle fiber size (HP:0012084)1.76984891
148EEG with generalized epileptiform discharges (HP:0011198)1.74006771
149Choreoathetosis (HP:0001266)1.73872019
150Abnormality of sodium homeostasis (HP:0010931)1.73614676
151Supranuclear gaze palsy (HP:0000605)1.73569120
152Incomplete penetrance (HP:0003829)1.73346068
153Anxiety (HP:0000739)1.73064658
154Rimmed vacuoles (HP:0003805)1.73020123
155Urinary urgency (HP:0000012)1.72864652
156Increased variability in muscle fiber diameter (HP:0003557)1.72105755
157Abnormal finger flexion creases (HP:0006143)1.71802420
158Abnormal autonomic nervous system physiology (HP:0012332)1.71437705
159Hypokalemic alkalosis (HP:0001949)1.71382513
160Xerostomia (HP:0000217)1.70593560
161Subaortic stenosis (HP:0001682)1.70333536
162Aplasia/Hypoplasia of the lens (HP:0008063)1.69244072
163EMG: myopathic abnormalities (HP:0003458)1.66918635
164Specific learning disability (HP:0001328)1.66608803
165Agitation (HP:0000713)1.65318130

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PHKG14.53746347
2PHKG24.53746347
3ARAF3.97957466
4EPHA43.65193764
5MAPKAPK53.60731644
6GRK53.24453116
7DAPK22.92082590
8LATS22.36383257
9CAMKK22.34909102
10BUB12.26662853
11FRK2.06265286
12MAP3K21.99763946
13MAP3K91.99229781
14KSR21.95654858
15CASK1.95222508
16PAK31.89784381
17MINK11.75318425
18OBSCN1.73855583
19CAMK2D1.71214414
20LIMK11.66448850
21TRIB31.65798771
22MAP2K71.62410272
23RIPK41.60681523
24CAMK2B1.60210149
25STK241.60053259
26CAMK1G1.58621931
27ILK1.56569365
28CAMK2G1.56536970
29PIM21.50188900
30CAMK1D1.49959299
31MAP2K41.48557538
32NTRK21.41404163
33CDK151.39116944
34PLK21.37746304
35MAPK151.35830566
36NTRK11.34348889
37CDK181.33648305
38ERBB31.33597648
39UHMK11.30749854
40MARK31.30029827
41SGK4941.29470182
42SGK2231.29470182
43BRAF1.28537682
44RPS6KA21.27519450
45CDK11A1.27033310
46PRPF4B1.27018066
47MAP3K41.24597470
48NME11.22338520
49PRKCG1.21785080
50MAP3K121.19564993
51FER1.08970261
52MAPKAPK31.07345918
53CAMK11.05683645
54DAPK11.02549159
55STK390.99747197
56CDK190.98155521
57TESK10.97136559
58PNCK0.96770648
59RET0.94844557
60LMTK20.94435901
61SGK20.92790099
62DYRK1A0.91458046
63MAPK130.90419048
64BCKDK0.89872707
65FGFR20.87310837
66CAMKK10.87263992
67CSNK1A1L0.85278700
68NUAK10.83358028
69AKT30.80190494
70SGK10.79551938
71PRKD30.79353025
72NTRK30.79004826
73CSNK1G20.76827538
74MARK10.75813249
75TTN0.75375572
76CAMK2A0.75290761
77MAP3K130.74602474
78CSNK1G30.73893797
79CDK50.73461297
80PTK2B0.72492881
81NEK10.72148875
82SIK30.71728467
83MARK20.70005829
84SGK30.68481754
85PAK60.67094893
86MAP3K10.63686121
87SCYL20.62574108
88PINK10.61781947
89MAP2K20.60076391
90CDK140.57970728
91PRKCZ0.57120960
92MAP2K10.56571769
93WNK30.55272709
94ICK0.53606733
95PRKCE0.53087452
96TESK20.50894216
97HIPK20.50000476
98RPS6KA30.49767248
99PKN10.48959952
100STK380.48094716
101IRAK10.45756087
102CAMK40.45685211
103MAPK100.45457985
104DAPK30.44931976
105SIK20.44186258
106STK110.43724489
107WNK40.43104759
108TYRO30.43048335
109STK160.40612334
110PRKG10.39377395
111CSNK1G10.38890260
112PRKCH0.38687098
113PDPK10.38312429
114MAPK120.37453323
115FGFR30.36950223
116MAP2K60.36575637
117CCNB10.36525270
118PRKACB0.36415388
119PDK10.35813102
120WNK10.35519006
121NEK90.35047013
122PRKAA10.35031449
123MAP3K50.34501325
124PRKACA0.34005018
125MAP3K110.32572531
126ROCK20.29921741
127CSNK1D0.29486273
128TRPM70.29140310
129RAF10.28151003
130TNK20.27449500
131FYN0.27341597
132CSNK1A10.26935505
133MOS0.26512615
134STK38L0.26510143
135PIK3CG0.26072556
136OXSR10.26041296
137MAP3K70.24655562
138ROCK10.24510261
139NEK60.24150442
140BMPR20.23104221

Predicted pathways (KEGG)

RankGene SetZ-score
1Olfactory transduction_Homo sapiens_hsa047409.31682783
2Vasopressin-regulated water reabsorption_Homo sapiens_hsa049623.45726985
3Synaptic vesicle cycle_Homo sapiens_hsa047212.31076147
4Phototransduction_Homo sapiens_hsa047442.01625166
5Insulin secretion_Homo sapiens_hsa049111.99343161
6Circadian entrainment_Homo sapiens_hsa047131.95788031
7Taste transduction_Homo sapiens_hsa047421.91143483
8Dopaminergic synapse_Homo sapiens_hsa047281.86036937
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.84804720
10Morphine addiction_Homo sapiens_hsa050321.72601138
11Parkinsons disease_Homo sapiens_hsa050121.70542691
12Glutamatergic synapse_Homo sapiens_hsa047241.67580085
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62220811
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.61904589
15Oxidative phosphorylation_Homo sapiens_hsa001901.58059381
16Cardiac muscle contraction_Homo sapiens_hsa042601.55578719
17GABAergic synapse_Homo sapiens_hsa047271.55504397
18Cholinergic synapse_Homo sapiens_hsa047251.54418352
19Aldosterone synthesis and secretion_Homo sapiens_hsa049251.50324154
20Salivary secretion_Homo sapiens_hsa049701.43998204
21Long-term potentiation_Homo sapiens_hsa047201.40821302
22Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.39764293
23Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38778657
24Gastric acid secretion_Homo sapiens_hsa049711.38672925
25Alzheimers disease_Homo sapiens_hsa050101.35217138
26Vibrio cholerae infection_Homo sapiens_hsa051101.29866532
27Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24160090
28GnRH signaling pathway_Homo sapiens_hsa049121.22565813
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.20252479
30cAMP signaling pathway_Homo sapiens_hsa040241.17866802
31Collecting duct acid secretion_Homo sapiens_hsa049661.16932705
32Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.12404417
33Calcium signaling pathway_Homo sapiens_hsa040201.06742895
34cGMP-PKG signaling pathway_Homo sapiens_hsa040221.04365872
35Serotonergic synapse_Homo sapiens_hsa047261.01119178
36Thyroid hormone synthesis_Homo sapiens_hsa049180.99657950
37Amphetamine addiction_Homo sapiens_hsa050310.97118580
38Bile secretion_Homo sapiens_hsa049760.96814346
39Melanogenesis_Homo sapiens_hsa049160.94311389
40Oxytocin signaling pathway_Homo sapiens_hsa049210.93025683
41Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.91090856
42Circadian rhythm_Homo sapiens_hsa047100.89953541
43Estrogen signaling pathway_Homo sapiens_hsa049150.88931658
44Fatty acid biosynthesis_Homo sapiens_hsa000610.88601870
45Huntingtons disease_Homo sapiens_hsa050160.88025847
46Renin secretion_Homo sapiens_hsa049240.84081365
47SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82003836
48Insulin signaling pathway_Homo sapiens_hsa049100.81496217
49Vascular smooth muscle contraction_Homo sapiens_hsa042700.81404220
50Gap junction_Homo sapiens_hsa045400.81199198
51Glucagon signaling pathway_Homo sapiens_hsa049220.80516833
52Vitamin B6 metabolism_Homo sapiens_hsa007500.80505803
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.79785276
54Pancreatic secretion_Homo sapiens_hsa049720.79537265
55Glioma_Homo sapiens_hsa052140.77748925
56Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.77670061
57Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.76569842
58Alcoholism_Homo sapiens_hsa050340.76208781
59Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.75954023
602-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.75684376
61Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75134038
62Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.73413449
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.67881079
64Pyruvate metabolism_Homo sapiens_hsa006200.65645946
65Nicotine addiction_Homo sapiens_hsa050330.65451606
66Inositol phosphate metabolism_Homo sapiens_hsa005620.65406295
67Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65249923
68Arginine biosynthesis_Homo sapiens_hsa002200.63513031
69Folate biosynthesis_Homo sapiens_hsa007900.62654933
70Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62640206
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62378858
72Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59490848
73Arginine and proline metabolism_Homo sapiens_hsa003300.59291871
74Dilated cardiomyopathy_Homo sapiens_hsa054140.58643977
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.58561002
76Tyrosine metabolism_Homo sapiens_hsa003500.57826795
77Oocyte meiosis_Homo sapiens_hsa041140.56025549
78Ovarian steroidogenesis_Homo sapiens_hsa049130.54326447
79MAPK signaling pathway_Homo sapiens_hsa040100.53179698
80Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.51153304
81Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.49426999
82Endometrial cancer_Homo sapiens_hsa052130.49036756
83Longevity regulating pathway - mammal_Homo sapiens_hsa042110.46009157
84Rap1 signaling pathway_Homo sapiens_hsa040150.45548326
85Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43227084
86Regulation of autophagy_Homo sapiens_hsa041400.41492555
87Ras signaling pathway_Homo sapiens_hsa040140.41046358
88Melanoma_Homo sapiens_hsa052180.40532509
89Nitrogen metabolism_Homo sapiens_hsa009100.37344992
90VEGF signaling pathway_Homo sapiens_hsa043700.36791234
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.36244956
92Phagosome_Homo sapiens_hsa041450.35727528
93Mineral absorption_Homo sapiens_hsa049780.35342560
94Dorso-ventral axis formation_Homo sapiens_hsa043200.34922021
95AMPK signaling pathway_Homo sapiens_hsa041520.34586144
96Sphingolipid metabolism_Homo sapiens_hsa006000.31885770
97Prolactin signaling pathway_Homo sapiens_hsa049170.31508763
98Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31251129
99Steroid biosynthesis_Homo sapiens_hsa001000.30550306
100Axon guidance_Homo sapiens_hsa043600.29813239
101ErbB signaling pathway_Homo sapiens_hsa040120.29697286
102Tight junction_Homo sapiens_hsa045300.29464346
103Long-term depression_Homo sapiens_hsa047300.29201364
104Propanoate metabolism_Homo sapiens_hsa006400.28747621
105Salmonella infection_Homo sapiens_hsa051320.28477296
106Central carbon metabolism in cancer_Homo sapiens_hsa052300.27546340
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.27318545
108Phospholipase D signaling pathway_Homo sapiens_hsa040720.27262662
109Sphingolipid signaling pathway_Homo sapiens_hsa040710.26485448
110Amoebiasis_Homo sapiens_hsa051460.25282115
111Cocaine addiction_Homo sapiens_hsa050300.25136557
112Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.24827873
113Adipocytokine signaling pathway_Homo sapiens_hsa049200.24699553
114Carbon metabolism_Homo sapiens_hsa012000.23852340
115mTOR signaling pathway_Homo sapiens_hsa041500.22010047
116Type II diabetes mellitus_Homo sapiens_hsa049300.21498575
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.20812335
118Prion diseases_Homo sapiens_hsa050200.20334571
119Butanoate metabolism_Homo sapiens_hsa006500.20220069
120Histidine metabolism_Homo sapiens_hsa003400.19953157
121Starch and sucrose metabolism_Homo sapiens_hsa005000.19210125
122Phenylalanine metabolism_Homo sapiens_hsa003600.19054210
123Endocytosis_Homo sapiens_hsa041440.18972662
124Thyroid cancer_Homo sapiens_hsa052160.17564432
125Glycerophospholipid metabolism_Homo sapiens_hsa005640.17564192

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