CUEDC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1actin-myosin filament sliding (GO:0033275)5.16628473
2muscle filament sliding (GO:0030049)5.16628473
3sarcomere organization (GO:0045214)5.07605075
4plasma membrane repair (GO:0001778)5.06465772
5regulation of skeletal muscle contraction (GO:0014819)5.03337582
6cardiac myofibril assembly (GO:0055003)4.65232224
7myofibril assembly (GO:0030239)4.56235787
8positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.43179987
9actin-mediated cell contraction (GO:0070252)4.39567535
10sarcoplasmic reticulum calcium ion transport (GO:0070296)4.26888427
11barbed-end actin filament capping (GO:0051016)4.18334672
12regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.12461402
13negative regulation of potassium ion transmembrane transport (GO:1901380)4.05042294
14negative regulation of potassium ion transmembrane transporter activity (GO:1901017)4.04925906
15regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.99591426
16regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.86076954
17planar cell polarity pathway involved in neural tube closure (GO:0090179)3.76086962
18dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.72876551
19regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.72863103
20actomyosin structure organization (GO:0031032)3.70312609
21cardiac muscle contraction (GO:0060048)3.69911053
22semaphorin-plexin signaling pathway (GO:0071526)3.68828322
23protein localization to endosome (GO:0036010)3.59794224
24striated muscle contraction (GO:0006941)3.52645277
25actin filament-based movement (GO:0030048)3.51290137
26skeletal muscle contraction (GO:0003009)3.49530545
27skin morphogenesis (GO:0043589)3.42956681
28regulation of membrane repolarization (GO:0060306)3.41926525
29regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.34923172
30regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.34861499
31creatine metabolic process (GO:0006600)3.34686779
32regulation of actin filament-based movement (GO:1903115)3.34431883
33cardiac muscle cell development (GO:0055013)3.33101997
34adherens junction assembly (GO:0034333)3.30905213
35epithelial cell-cell adhesion (GO:0090136)3.21103118
36adult heart development (GO:0007512)3.20874805
37regulation of cell communication by electrical coupling (GO:0010649)3.20548205
38Golgi transport vesicle coating (GO:0048200)3.19797991
39COPI coating of Golgi vesicle (GO:0048205)3.19797991
40cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.17673419
41cardiac cell development (GO:0055006)3.17260443
42positive regulation of receptor recycling (GO:0001921)3.17245795
43cell-cell junction maintenance (GO:0045217)3.14981258
44focal adhesion assembly (GO:0048041)3.13022997
45cell-substrate adherens junction assembly (GO:0007045)3.13022997
46regulation of glucose import in response to insulin stimulus (GO:2001273)3.11522526
47negative regulation of protein localization to cell surface (GO:2000009)3.10080501
48cell communication by electrical coupling (GO:0010644)3.08900778
49positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.07875612
50regulation of relaxation of muscle (GO:1901077)3.04778154
51ventricular cardiac muscle cell action potential (GO:0086005)2.98708896
52stress fiber assembly (GO:0043149)2.98053422
53regulation of striated muscle contraction (GO:0006942)2.97310968
54skeletal muscle adaptation (GO:0043501)2.97295070
55response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.95459861
56cell-substrate junction assembly (GO:0007044)2.94167442
57regulation of calcium ion transmembrane transport (GO:1903169)2.92555711
58regulation of calcium ion transmembrane transporter activity (GO:1901019)2.92555711
59protein retention in ER lumen (GO:0006621)2.89220179
60regulation of skeletal muscle cell differentiation (GO:2001014)2.88985685
61heart trabecula formation (GO:0060347)2.87430228
62endothelial cell chemotaxis (GO:0035767)2.87299073
63regulation of p38MAPK cascade (GO:1900744)2.86872645
64apoptotic cell clearance (GO:0043277)2.86858045
65regulation of early endosome to late endosome transport (GO:2000641)2.86744634
66positive regulation of extracellular matrix organization (GO:1903055)2.85666483
67basement membrane organization (GO:0071711)2.85468117
68muscle contraction (GO:0006936)2.85227472
69cell communication involved in cardiac conduction (GO:0086065)2.83255713
70regulation of extracellular matrix disassembly (GO:0010715)2.80329848
71neuromuscular junction development (GO:0007528)2.77447172
72positive regulation of cation channel activity (GO:2001259)2.71945322
73positive regulation of blood vessel endothelial cell migration (GO:0043536)2.71696637
74regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.71571694
75negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.71134120
76cardiac muscle tissue morphogenesis (GO:0055008)2.70229837
77negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.69608743
78maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.68564395
79positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.67445304
80regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.67282694
81axonemal dynein complex assembly (GO:0070286)2.66565009
82membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.64630713
83potassium ion import (GO:0010107)2.63308316
84response to inactivity (GO:0014854)2.62549096
85retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62207140
86muscle tissue morphogenesis (GO:0060415)2.62016529
87cardiac muscle hypertrophy (GO:0003300)2.60439999
88striated muscle hypertrophy (GO:0014897)2.59916375
89muscle system process (GO:0003012)2.58688460
90carnitine shuttle (GO:0006853)2.58565699
91negative regulation of fatty acid transport (GO:2000192)2.57762909
92vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.54831455
93Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.54473814
94embryo implantation (GO:0007566)2.52889485
95negative regulation of chondrocyte differentiation (GO:0032331)2.52677880
96regulation of sarcomere organization (GO:0060297)2.52203003
97maternal placenta development (GO:0001893)2.51964213
98muscle cell cellular homeostasis (GO:0046716)2.49242074
99motile cilium assembly (GO:0044458)2.47704019
100positive regulation of potassium ion transmembrane transport (GO:1901381)2.46667777
101tooth mineralization (GO:0034505)2.46537232
102camera-type eye morphogenesis (GO:0048593)2.46324798
103regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.43854454
104negative regulation of cytosolic calcium ion concentration (GO:0051481)2.43309892
105regulation of synapse structural plasticity (GO:0051823)2.43146568
106protein heterotrimerization (GO:0070208)2.42540416
107hemidesmosome assembly (GO:0031581)2.42504957
108negative regulation of potassium ion transport (GO:0043267)2.41870173
109ventricular cardiac muscle tissue morphogenesis (GO:0055010)2.41240673
110positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.41143064
111striated muscle adaptation (GO:0014888)2.41137549
112muscle fiber development (GO:0048747)2.41092939
113mannose metabolic process (GO:0006013)2.41081787
114endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.40966071
115desmosome organization (GO:0002934)2.40172655
116regulation of extracellular matrix organization (GO:1903053)2.39765538
117establishment of apical/basal cell polarity (GO:0035089)2.38039052
118cochlea morphogenesis (GO:0090103)2.37799872
119myoblast fusion (GO:0007520)2.37688765
120photoreceptor cell differentiation (GO:0046530)2.37406629
121eye photoreceptor cell differentiation (GO:0001754)2.37406629
122vascular endothelial growth factor signaling pathway (GO:0038084)2.37324953
123protein targeting to plasma membrane (GO:0072661)2.37165671
124cell junction maintenance (GO:0034331)2.36305203
125cardiac muscle cell action potential (GO:0086001)2.36103344
126actin filament bundle assembly (GO:0051017)2.35926480
127actin filament bundle organization (GO:0061572)2.35926480
128activation of Rac GTPase activity (GO:0032863)2.35465191
129syncytium formation by plasma membrane fusion (GO:0000768)2.35191921
130regulation of establishment of planar polarity (GO:0090175)2.34667583
131neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.34525834
132cytoskeletal anchoring at plasma membrane (GO:0007016)2.34317214
133striated muscle cell development (GO:0055002)2.34296939
134membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.33938726
135endodermal cell differentiation (GO:0035987)2.33913805
136regulation of cardiac muscle contraction (GO:0055117)2.32922827
137cardiac muscle cell action potential involved in contraction (GO:0086002)2.32592734
138regulation of potassium ion transmembrane transport (GO:1901379)2.32307645
139regulation of potassium ion transmembrane transporter activity (GO:1901016)2.32215156
140regulation of cation channel activity (GO:2001257)2.31484931
141amyloid precursor protein catabolic process (GO:0042987)2.31455356
142layer formation in cerebral cortex (GO:0021819)2.30303825
143negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.30185605
144positive regulation of protein dephosphorylation (GO:0035307)2.29700144
145branching involved in mammary gland duct morphogenesis (GO:0060444)2.29308488
146positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.28942254
147substrate-dependent cell migration (GO:0006929)2.28801312
148membrane protein ectodomain proteolysis (GO:0006509)2.28456666
149regulation of cardiac muscle cell contraction (GO:0086004)2.28408876
150negative regulation of catenin import into nucleus (GO:0035414)2.28394701
151hypotonic response (GO:0006971)2.28261907
152regulation of the force of heart contraction (GO:0002026)2.27085960
153positive regulation of Cdc42 GTPase activity (GO:0043089)2.26437271
154positive regulation of ion transmembrane transporter activity (GO:0032414)2.26354145
155cell migration in hindbrain (GO:0021535)2.26035557
156apoptotic process involved in morphogenesis (GO:0060561)2.25885599
157regulation of heart rate by cardiac conduction (GO:0086091)2.25600040
158regulation of axon extension involved in axon guidance (GO:0048841)2.25171057
159regulation of heart rate (GO:0002027)2.24659901
160coronary vasculature morphogenesis (GO:0060977)2.24080428
161cardiac conduction (GO:0061337)2.23924229
162activation of protein kinase A activity (GO:0034199)2.23433110
163regulation of heart contraction (GO:0008016)2.23162555
164cell migration involved in heart development (GO:0060973)2.22700191
165epithelial cell differentiation involved in prostate gland development (GO:0060742)2.22083839
166insulin-like growth factor receptor signaling pathway (GO:0048009)2.21994607
167positive regulation of potassium ion transport (GO:0043268)2.21808047
168detection of calcium ion (GO:0005513)2.21720044
169negative regulation of cell size (GO:0045792)2.21711420
170cell volume homeostasis (GO:0006884)2.21361632
171muscle structure development (GO:0061061)2.20853708
172ear development (GO:0043583)2.20749970
173membrane tubulation (GO:0097320)2.19733904
174regulation of membrane protein ectodomain proteolysis (GO:0051043)2.19613662
175cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.19269976
176positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.18915127
177muscle organ development (GO:0007517)2.18841513
178chondroitin sulfate biosynthetic process (GO:0030206)2.17785270
179type B pancreatic cell proliferation (GO:0044342)2.17457010
180glial cell migration (GO:0008347)2.16793224
181kidney mesenchyme development (GO:0072074)2.16436957
182actin filament depolymerization (GO:0030042)2.15836424
183regulation of fatty acid beta-oxidation (GO:0031998)2.14980297
184macroautophagy (GO:0016236)2.14254619
185amyloid precursor protein metabolic process (GO:0042982)2.13581533
186response to laminar fluid shear stress (GO:0034616)2.13339694
187Rho protein signal transduction (GO:0007266)2.13189051
188atrioventricular valve morphogenesis (GO:0003181)2.12422875

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.57260093
2TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.90010749
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.48528341
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.45915992
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.45915992
6RACK7_27058665_Chip-Seq_MCF-7_Human2.44842434
7EZH2_27304074_Chip-Seq_ESCs_Mouse2.43594506
8ELK3_25401928_ChIP-Seq_HUVEC_Human2.37213924
9JARID2_20064375_ChIP-Seq_MESCs_Mouse2.28948763
10STAT6_21828071_ChIP-Seq_BEAS2B_Human2.28892507
11SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.27219665
12DROSHA_22980978_ChIP-Seq_HELA_Human2.25955867
13* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.24958748
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23958846
15EZH2_27294783_Chip-Seq_ESCs_Mouse2.22835807
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.19469604
17NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17964017
18EP300_21415370_ChIP-Seq_HL-1_Mouse2.15480439
19* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.11071602
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.02677680
21EED_16625203_ChIP-ChIP_MESCs_Mouse2.01324840
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.97754249
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.97742269
24* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.96828051
25RNF2_27304074_Chip-Seq_ESCs_Mouse1.96577457
26* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.93889368
27AR_21572438_ChIP-Seq_LNCaP_Human1.89760954
28SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.88394872
29RARG_19884340_ChIP-ChIP_MEFs_Mouse1.84500112
30CDX2_19796622_ChIP-Seq_MESCs_Mouse1.81790313
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.78760187
32KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78074391
33TRIM28_21343339_ChIP-Seq_HEK293_Human1.77236164
34VDR_21846776_ChIP-Seq_THP-1_Human1.70949185
35TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.68236238
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67145248
37KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.66373186
38TBX20_22328084_ChIP-Seq_HEART_Mouse1.64529531
39TBX20_22080862_ChIP-Seq_HEART_Mouse1.64529531
40* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.61489229
41KDM2B_26808549_Chip-Seq_K562_Human1.61181121
42* TCF7_22412390_ChIP-Seq_EML_Mouse1.60487759
43ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.59587412
44ESR2_21235772_ChIP-Seq_MCF-7_Human1.58771148
45ZFP281_18757296_ChIP-ChIP_E14_Mouse1.58189636
46PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.57050141
47ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.56510799
48TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.55186324
49* ESR1_20079471_ChIP-ChIP_T-47D_Human1.52876718
50* RUNX1_27514584_Chip-Seq_MCF-7_Human1.49995964
51SMC4_20622854_ChIP-Seq_HELA_Human1.45018508
52WT1_25993318_ChIP-Seq_PODOCYTE_Human1.43716114
53TP53_20018659_ChIP-ChIP_R1E_Mouse1.43157839
54KDM2B_26808549_Chip-Seq_SUP-B15_Human1.40962658
55RARB_27405468_Chip-Seq_BRAIN_Mouse1.39864222
56GBX2_23144817_ChIP-Seq_PC3_Human1.38458992
57RING1B_27294783_Chip-Seq_ESCs_Mouse1.36843937
58* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.34514519
59* PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.32855223
60ERG_21242973_ChIP-ChIP_JURKAT_Human1.31053115
61TET1_21451524_ChIP-Seq_MESCs_Mouse1.30423264
62SA1_27219007_Chip-Seq_ERYTHROID_Human1.30110887
63* TP53_22127205_ChIP-Seq_IMR90_Human1.28260305
64CTCF_27219007_Chip-Seq_Bcells_Human1.27444345
65CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27413574
66* RING1B_27294783_Chip-Seq_NPCs_Mouse1.26957852
67SRY_22984422_ChIP-ChIP_TESTIS_Rat1.24932652
68ISL1_27105846_Chip-Seq_CPCs_Mouse1.24036578
69RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.23389722
70P68_20966046_ChIP-Seq_HELA_Human1.23349696
71* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.22366638
72SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.21012036
73* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.20673390
74* DNAJC2_21179169_ChIP-ChIP_NT2_Human1.20544178
75CBX2_27304074_Chip-Seq_ESCs_Mouse1.20340694
76* ATF3_27146783_Chip-Seq_COLON_Human1.19449305
77CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.19448252
78KDM2B_26808549_Chip-Seq_DND41_Human1.19354055
79* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.18312490
80* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17635626
81* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15999200
82TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15902614
83* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.14741122
84SMC3_22415368_ChIP-Seq_MEFs_Mouse1.14491228
85CLOCK_20551151_ChIP-Seq_293T_Human1.13425517
86BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13001795
87AHR_22903824_ChIP-Seq_MCF-7_Human1.12838070
88MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.12740692
89TET1_21490601_ChIP-Seq_MESCs_Mouse1.11679094
90* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09990999
91KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.09876592
92CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09727712
93* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.09430916
94* P63_26484246_Chip-Seq_KERATINOCYTES_Human1.08493757
95ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08467806
96ZFP281_27345836_Chip-Seq_ESCs_Mouse1.08455331
97LXR_22292898_ChIP-Seq_THP-1_Human1.08442942
98ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08040575
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.07233910
100MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.07045739
101UBF1/2_26484160_Chip-Seq_HMECs_Human1.06934154
102CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.06392815
103* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.06081697
104ZNF274_21170338_ChIP-Seq_K562_Hela1.04111670
105* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04078341
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.03856145
107KDM2B_26808549_Chip-Seq_JURKAT_Human1.03694312
108ARNT_22903824_ChIP-Seq_MCF-7_Human1.03235344
109TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.03199390
110NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.02213838
111VDR_24763502_ChIP-Seq_THP-1_Human1.01624611
112DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99400123
113* SOX2_27498859_Chip-Seq_STOMACH_Mouse0.98696515
114* CREB1_26743006_Chip-Seq_LNCaP_Human0.98203014
115NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97783026
116REST_21632747_ChIP-Seq_MESCs_Mouse0.97636678
117AR_19668381_ChIP-Seq_PC3_Human0.97361556
118TP63_17297297_ChIP-ChIP_HaCaT_Human0.95272095
119ESR1_21235772_ChIP-Seq_MCF-7_Human0.94564557
120PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.94275480
121REST_18959480_ChIP-ChIP_MESCs_Mouse0.93747385
122KLF5_25053715_ChIP-Seq_YYC3_Human0.93434180
123ZNF263_19887448_ChIP-Seq_K562_Human0.93189413
124* NFIB_24661679_ChIP-Seq_LUNG_Mouse0.92985155
125RXR_22158963_ChIP-Seq_LIVER_Mouse0.92972422
126HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92731332
127THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.92295143
128SOX2_21211035_ChIP-Seq_LN229_Gbm0.91799538
129* TP53_23651856_ChIP-Seq_MEFs_Mouse0.90803605
130PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90784627
131* SMAD4_21741376_ChIP-Seq_HESCs_Human0.90289463
132KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90278076
133CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89941127
134P300_27058665_Chip-Seq_ZR-75-30cells_Human0.89029993
135IKZF1_21737484_ChIP-ChIP_HCT116_Human0.88820875
136WT1_19549856_ChIP-ChIP_CCG9911_Human0.87340942
137PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.85918993
138* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.85262848
139* SMAD3_21741376_ChIP-Seq_HESCs_Human0.85012927
140MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.84444638
141* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.82814470
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82623410
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.82208635
144* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.81981275
145SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.80197152
146TP63_22573176_ChIP-Seq_HFKS_Human0.80073246

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000751_myopathy4.72403047
2MP0002837_dystrophic_cardiac_calcinosis4.48907505
3MP0004145_abnormal_muscle_electrophysio3.65609027
4MP0000749_muscle_degeneration3.51612232
5MP0003646_muscle_fatigue3.38800196
6MP0004084_abnormal_cardiac_muscle3.12780620
7MP0004036_abnormal_muscle_relaxation3.11039438
8MP0005058_abnormal_lysosome_morphology2.85425428
9MP0004215_abnormal_myocardial_fiber2.61236294
10MP0004087_abnormal_muscle_fiber2.42219302
11MP0005257_abnormal_intraocular_pressure2.39521188
12MP0002106_abnormal_muscle_physiology2.38427007
13MP0000750_abnormal_muscle_regeneration2.36784821
14MP0000747_muscle_weakness2.35699393
15MP0005330_cardiomyopathy2.24963616
16MP0003566_abnormal_cell_adhesion2.23758259
17MP0005620_abnormal_muscle_contractility2.22755423
18MP0000759_abnormal_skeletal_muscle2.20030175
19MP0005451_abnormal_body_composition2.16482595
20MP0002877_abnormal_melanocyte_morpholog2.13062229
21MP0005369_muscle_phenotype2.11361001
22MP0004233_abnormal_muscle_weight2.10073460
23MP0001849_ear_inflammation2.08003886
24MP0004130_abnormal_muscle_cell2.07694883
25MP0003137_abnormal_impulse_conducting2.00961208
26MP0003191_abnormal_cellular_cholesterol1.90279298
27MP0004510_myositis1.88199684
28MP0002269_muscular_atrophy1.87137830
29MP0003091_abnormal_cell_migration1.85642702
30MP0002972_abnormal_cardiac_muscle1.82622551
31MP0005076_abnormal_cell_differentiation1.81654942
32MP0002234_abnormal_pharynx_morphology1.79800996
33MP0005623_abnormal_meninges_morphology1.75854345
34MP0003283_abnormal_digestive_organ1.68902888
35MP0010234_abnormal_vibrissa_follicle1.68851201
36MP0008438_abnormal_cutaneous_collagen1.68684729
37MP0009780_abnormal_chondrocyte_physiolo1.68275854
38MP0009840_abnormal_foam_cell1.62079345
39MP0003950_abnormal_plasma_membrane1.59207287
40MP0003453_abnormal_keratinocyte_physiol1.59077123
41MP0010630_abnormal_cardiac_muscle1.56655984
42MP0002108_abnormal_muscle_morphology1.56326480
43MP0000733_abnormal_muscle_development1.54536607
44MP0000013_abnormal_adipose_tissue1.51865036
45MP0003329_amyloid_beta_deposits1.50960899
46MP0005023_abnormal_wound_healing1.50506894
47MP0005409_darkened_coat_color1.48254985
48MP0006072_abnormal_retinal_apoptosis1.47833036
49MP0004085_abnormal_heartbeat1.47647703
50MP0002249_abnormal_larynx_morphology1.44002127
51MP0008775_abnormal_heart_ventricle1.41111198
52MP0006138_congestive_heart_failure1.40851102
53MP0009384_cardiac_valve_regurgitation1.39952604
54MP0008260_abnormal_autophagy1.39849174
55MP0001544_abnormal_cardiovascular_syste1.39600450
56MP0005385_cardiovascular_system_phenoty1.39600450
57MP0004859_abnormal_synaptic_plasticity1.38287483
58MP0004484_altered_response_of1.38136675
59MP0008961_abnormal_basal_metabolism1.37839275
60MP0004270_analgesia1.37147159
61MP0000767_abnormal_smooth_muscle1.34241726
62MP0005248_abnormal_Harderian_gland1.33971643
63MP0003172_abnormal_lysosome_physiology1.33684195
64MP0005503_abnormal_tendon_morphology1.31774112
65MP0000003_abnormal_adipose_tissue1.26235235
66MP0005508_abnormal_skeleton_morphology1.24810459
67MP0002060_abnormal_skin_morphology1.22236924
68MP0001299_abnormal_eye_distance/1.20651549
69MP0005375_adipose_tissue_phenotype1.17292364
70MP0003075_altered_response_to1.16211098
71MP0005275_abnormal_skin_tensile1.15129122
72MP0001542_abnormal_bone_strength1.15053807
73MP0005551_abnormal_eye_electrophysiolog1.11321431
74MP0000678_abnormal_parathyroid_gland1.10873532
75MP0002909_abnormal_adrenal_gland1.09646074
76MP0005666_abnormal_adipose_tissue1.09081734
77MP0003300_gastrointestinal_ulcer1.08005373
78MP0001348_abnormal_lacrimal_gland1.07054120
79MP0004272_abnormal_basement_membrane1.06670598
80MP0002089_abnormal_postnatal_growth/wei1.06544553
81MP0010030_abnormal_orbit_morphology1.05295028
82MP0008569_lethality_at_weaning1.04951682
83MP0000858_altered_metastatic_potential1.03327274
84MP0002998_abnormal_bone_remodeling1.03229987
85MP0003385_abnormal_body_wall1.02499918
86MP0004043_abnormal_pH_regulation1.01151468
87MP0004858_abnormal_nervous_system0.99521035
88MP0003279_aneurysm0.99120508
89MP0003690_abnormal_glial_cell0.98229600
90MP0000778_abnormal_nervous_system0.97811512
91MP0004185_abnormal_adipocyte_glucose0.96398596
92MP0005165_increased_susceptibility_to0.95664416
93MP0002653_abnormal_ependyma_morphology0.94920779
94MP0003635_abnormal_synaptic_transmissio0.94426039
95MP0003705_abnormal_hypodermis_morpholog0.93769352
96MP0005390_skeleton_phenotype0.91971026
97MP0002127_abnormal_cardiovascular_syste0.91623473
98MP0000343_altered_response_to0.88899741
99MP0009250_abnormal_appendicular_skeleto0.88092274
100MP0003303_peritoneal_inflammation0.85873438
101MP0001958_emphysema0.85746005
102MP0003879_abnormal_hair_cell0.85505952
103MP0001533_abnormal_skeleton_physiology0.84163049
104MP0005253_abnormal_eye_physiology0.84060052
105MP0000467_abnormal_esophagus_morphology0.83971202
106MP0005595_abnormal_vascular_smooth0.83479200
107MP0000534_abnormal_ureter_morphology0.83278041
108MP0002796_impaired_skin_barrier0.82808607
109MP0005083_abnormal_biliary_tract0.82748835
110MP0009278_abnormal_bone_marrow0.81916271
111MP0005423_abnormal_somatic_nervous0.81409546
112MP0003122_maternal_imprinting0.81408746
113MP0002332_abnormal_exercise_endurance0.79937298
114MP0000681_abnormal_thyroid_gland0.79559270
115MP0003828_pulmonary_edema0.79202907
116MP0005164_abnormal_response_to0.78880910
117MP0000604_amyloidosis0.77834202
118MP0009053_abnormal_anal_canal0.77618461
119MP0003634_abnormal_glial_cell0.76781968
120MP0000428_abnormal_craniofacial_morphol0.75241747
121MP0005670_abnormal_white_adipose0.74809714
122MP0001879_abnormal_lymphatic_vessel0.73484598
123MP0002896_abnormal_bone_mineralization0.72960439
124MP0001243_abnormal_dermal_layer0.72892454
125MP0000266_abnormal_heart_morphology0.71855388
126MP0002882_abnormal_neuron_morphology0.71205452
127MP0000955_abnormal_spinal_cord0.71128919
128MP0002113_abnormal_skeleton_development0.71072030
129MP0002295_abnormal_pulmonary_circulatio0.70676372
130MP0002932_abnormal_joint_morphology0.69258541
131MP0002272_abnormal_nervous_system0.69055978
132MP0000537_abnormal_urethra_morphology0.68901965
133MP0010368_abnormal_lymphatic_system0.68364995
134MP0004885_abnormal_endolymph0.68331050
135MP0000163_abnormal_cartilage_morphology0.67734558
136MP0000049_abnormal_middle_ear0.67168519
137MP0002090_abnormal_vision0.66476293
138MP0005187_abnormal_penis_morphology0.66129603
139MP0000762_abnormal_tongue_morphology0.65548286
140MP0002734_abnormal_mechanical_nocicepti0.64944584
141MP0003045_fibrosis0.64615136
142MP0005195_abnormal_posterior_eye0.63341497
143MP0003221_abnormal_cardiomyocyte_apopto0.61104488
144MP0002184_abnormal_innervation0.61014763
145MP0000462_abnormal_digestive_system0.61005052
146MP0002752_abnormal_somatic_nervous0.60727205
147MP0003942_abnormal_urinary_system0.60279336
148MP0002063_abnormal_learning/memory/cond0.60272227
149MP0000230_abnormal_systemic_arterial0.60140651
150MP0002064_seizures0.59170510
151MP0000920_abnormal_myelination0.57804949
152MP0002067_abnormal_sensory_capabilities0.57669551
153MP0003935_abnormal_craniofacial_develop0.57466823

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)5.77403819
2Muscle hypertrophy of the lower extremities (HP:0008968)5.32829566
3Calf muscle hypertrophy (HP:0008981)5.17342404
4Muscle fiber splitting (HP:0003555)5.13676727
5Exercise-induced muscle cramps (HP:0003710)4.96563625
6Sudden death (HP:0001699)4.76155352
7Muscle fiber inclusion bodies (HP:0100299)4.69161953
8Hyporeflexia of lower limbs (HP:0002600)4.67442416
9Type 1 muscle fiber predominance (HP:0003803)4.66090708
10Difficulty running (HP:0009046)4.60936953
11Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.59159467
12Abnormality of the calf musculature (HP:0001430)4.36647914
13Protrusio acetabuli (HP:0003179)4.27394103
14Increased connective tissue (HP:0009025)4.13361655
15Nemaline bodies (HP:0003798)4.01334452
16EMG: myopathic abnormalities (HP:0003458)3.93534940
17Increased variability in muscle fiber diameter (HP:0003557)3.89639047
18Abnormality of skeletal muscle fiber size (HP:0012084)3.68740147
19Myotonia (HP:0002486)3.67780438
20Ventricular tachycardia (HP:0004756)3.54243629
21Myoglobinuria (HP:0002913)3.50299946
22Subaortic stenosis (HP:0001682)3.46415145
23Abnormality of the left ventricular outflow tract (HP:0011103)3.46415145
24Atrial fibrillation (HP:0005110)3.35031443
25Round ear (HP:0100830)3.24032660
26Prolonged QT interval (HP:0001657)3.14180427
27Primary atrial arrhythmia (HP:0001692)3.13934003
28Obstructive sleep apnea (HP:0002870)3.05866477
29Central scotoma (HP:0000603)3.04310017
30Distal arthrogryposis (HP:0005684)2.96066948
31Supraventricular tachycardia (HP:0004755)2.95251580
32Difficulty climbing stairs (HP:0003551)2.94344847
33Supraventricular arrhythmia (HP:0005115)2.93267177
34Cervical subluxation (HP:0003308)2.92394741
35Myopathic facies (HP:0002058)2.91403237
36Bundle branch block (HP:0011710)2.91373145
37Hyperacusis (HP:0010780)2.88595217
38Muscle stiffness (HP:0003552)2.82861286
39Lipoatrophy (HP:0100578)2.81884168
40Vascular tortuosity (HP:0004948)2.78028193
41Mildly elevated creatine phosphokinase (HP:0008180)2.77497478
42Nuclear cataract (HP:0100018)2.77480413
43Broad metatarsal (HP:0001783)2.74850234
44Asymmetric septal hypertrophy (HP:0001670)2.73986042
45Arterial tortuosity (HP:0005116)2.73050319
46Vertebral compression fractures (HP:0002953)2.72953716
47Scapular winging (HP:0003691)2.65699704
48Fragile skin (HP:0001030)2.60872355
49Broad face (HP:0000283)2.58527511
50Right ventricular cardiomyopathy (HP:0011663)2.56121415
51Upper limb amyotrophy (HP:0009129)2.55293163
52Distal upper limb amyotrophy (HP:0007149)2.55293163
53Syncope (HP:0001279)2.50569088
54Ulnar bowing (HP:0003031)2.50249014
55Stridor (HP:0010307)2.49368466
56Short nail (HP:0001799)2.48303754
57Neck muscle weakness (HP:0000467)2.47984780
58Hypoplastic ischia (HP:0003175)2.41354441
59Mitral regurgitation (HP:0001653)2.40060992
60Spinal rigidity (HP:0003306)2.39606384
61Atrophic scars (HP:0001075)2.39241377
62Rimmed vacuoles (HP:0003805)2.37002573
63Dilated cardiomyopathy (HP:0001644)2.35552733
64Neurofibrillary tangles (HP:0002185)2.34795738
65Achilles tendon contracture (HP:0001771)2.34410076
66Limb-girdle muscle atrophy (HP:0003797)2.32417191
67Aortic dissection (HP:0002647)2.31664678
68Ventricular fibrillation (HP:0001663)2.29440678
69Aortic aneurysm (HP:0004942)2.25956623
70Gowers sign (HP:0003391)2.25709375
71Ventricular arrhythmia (HP:0004308)2.24035813
72Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.22779217
73Distal lower limb amyotrophy (HP:0008944)2.22575494
74Abnormal EKG (HP:0003115)2.22567064
75Abnormality of glycolipid metabolism (HP:0010969)2.22142380
76Abnormality of liposaccharide metabolism (HP:0010968)2.22142380
77Abnormality of glycosphingolipid metabolism (HP:0004343)2.22142380
78Ankle contracture (HP:0006466)2.20038380
79Calcaneovalgus deformity (HP:0001848)2.19112003
80Thin bony cortex (HP:0002753)2.17454772
81Abnormality of the nasal mucosa (HP:0000433)2.17194438
82Abnormality of dentin (HP:0010299)2.16174941
83Scotoma (HP:0000575)2.15552703
84Flat acetabular roof (HP:0003180)2.14807788
85Ulnar deviation of the wrist (HP:0003049)2.13969243
86Dysostosis multiplex (HP:0000943)2.12788921
87Heart block (HP:0012722)2.12426928
88Centrally nucleated skeletal muscle fibers (HP:0003687)2.12071401
89Rhabdomyolysis (HP:0003201)2.11912648
90Lower limb amyotrophy (HP:0007210)2.11438403
91Axonal loss (HP:0003447)2.10444564
92Abnormality of the ischium (HP:0003174)2.08104872
93Limb-girdle muscle weakness (HP:0003325)2.08069435
94Nasal polyposis (HP:0100582)2.07787931
95Slender build (HP:0001533)2.07401931
96Proximal amyotrophy (HP:0007126)2.07032972
97Abnormality of the distal phalanges of the toes (HP:0010182)2.06917383
98Abnormal atrioventricular conduction (HP:0005150)2.06877760
99Blue sclerae (HP:0000592)2.05695495
100Bulbar palsy (HP:0001283)2.05448323
101Muscular dystrophy (HP:0003560)2.05139943
102Generalized amyotrophy (HP:0003700)2.04934911
103Abnormality of the Achilles tendon (HP:0005109)2.04351663
104Cerebral inclusion bodies (HP:0100314)2.04007771
105Atelectasis (HP:0100750)2.03431439
106Aneurysm (HP:0002617)2.01186522
107Joint stiffness (HP:0001387)2.01005316
108Absent phalangeal crease (HP:0006109)1.99495816
109Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99301919
110Deformed tarsal bones (HP:0008119)1.98367625
111Abnormality of the foot musculature (HP:0001436)1.96907166
112Mucopolysacchariduria (HP:0008155)1.96741175
113Urinary glycosaminoglycan excretion (HP:0003541)1.96741175
114EMG: neuropathic changes (HP:0003445)1.95786057
115Genu recurvatum (HP:0002816)1.95475649
116Left ventricular hypertrophy (HP:0001712)1.94824041
117Foot dorsiflexor weakness (HP:0009027)1.93861603
118Turricephaly (HP:0000262)1.93544385
119Interstitial pulmonary disease (HP:0006530)1.93475047
120Shallow orbits (HP:0000586)1.92812938
121Wormian bones (HP:0002645)1.91508947
122Abnormality of mucopolysaccharide metabolism (HP:0011020)1.91158514
123Abnormality of polysaccharide metabolism (HP:0011012)1.91158514
124Abnormality of glycosaminoglycan metabolism (HP:0004371)1.91158514
125Distal lower limb muscle weakness (HP:0009053)1.90557761
126Long toe (HP:0010511)1.88043522
127Abnormality of the shoulder girdle musculature (HP:0001435)1.86815715
128Dilatation of the ascending aorta (HP:0005111)1.86296563
129Hand muscle atrophy (HP:0009130)1.83978700
130Pheochromocytoma (HP:0002666)1.83639180
131Premature rupture of membranes (HP:0001788)1.81758260
132Absent frontal sinuses (HP:0002688)1.81465311
133Neonatal short-limb short stature (HP:0008921)1.81442540
134Aortic regurgitation (HP:0001659)1.79826920
135Spinal cord compression (HP:0002176)1.78359524
136Biconcave vertebral bodies (HP:0004586)1.77020741
137Large for gestational age (HP:0001520)1.76495213
138Osteolytic defects of the hand bones (HP:0009699)1.75897890
139Osteolytic defects of the phalanges of the hand (HP:0009771)1.75897890
140Hip contracture (HP:0003273)1.75358910
141Mitral stenosis (HP:0001718)1.74730698
142Elbow flexion contracture (HP:0002987)1.73870318
143Shoulder girdle muscle weakness (HP:0003547)1.73522185
144Atrioventricular block (HP:0001678)1.73377122
145Frequent falls (HP:0002359)1.73359627
146Palpitations (HP:0001962)1.73340163
147Congenital glaucoma (HP:0001087)1.72720143
148Coxa vara (HP:0002812)1.71277243
149Rapidly progressive (HP:0003678)1.71239802
150Termporal pattern (HP:0011008)1.69573584
151Insidious onset (HP:0003587)1.69573584
152Hyperkalemia (HP:0002153)1.67991507
153Generalized muscle weakness (HP:0003324)1.63676514
154Abnormality of the hip-girdle musculature (HP:0001445)1.63361892
155Abnormality of the musculature of the pelvis (HP:0001469)1.63361892
156Bladder diverticulum (HP:0000015)1.62929108
157Facial diplegia (HP:0001349)1.61933592
158Abnormal finger flexion creases (HP:0006143)1.61123622
159Neuroendocrine neoplasm (HP:0100634)1.55386127
160Areflexia of lower limbs (HP:0002522)1.53450328
161Cerebral aneurysm (HP:0004944)1.52884042
162Dysmetric saccades (HP:0000641)1.52592348
163Bronchomalacia (HP:0002780)1.51545803
164Bell-shaped thorax (HP:0001591)1.50181424
165Buphthalmos (HP:0000557)1.49674356
166Pelvic girdle muscle weakness (HP:0003749)1.49512437

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.85141264
2PHKG24.21703174
3PHKG14.21703174
4OBSCN3.61416935
5EPHA23.56905599
6TRIB33.04595466
7DMPK2.71110931
8ERN12.43942556
9MST1R2.28944863
10TESK12.21395768
11LMTK22.14782756
12IRAK32.07854478
13MARK11.73813122
14EPHB21.73413798
15PIK3CA1.70976561
16PDGFRA1.67363181
17SMG11.65729358
18PKN21.62311832
19INSRR1.58116601
20MYLK1.57149731
21MAP2K31.55930163
22PAK41.49933767
23MUSK1.48922613
24MAP3K31.48834025
25PAK31.38931387
26MET1.38858561
27MAP3K71.38679182
28WNK41.38413969
29SIK11.35864955
30EPHB11.34911603
31PRPF4B1.33292144
32RIPK11.30726427
33CAMK1G1.28051820
34PAK61.26571464
35DDR21.26549683
36PINK11.24978125
37PRKD11.23791730
38PKN11.21786336
39UHMK11.18156754
40ILK1.16741562
41STK391.14118934
42ICK1.13989646
43NME21.13696260
44MAPKAPK31.12631098
45NTRK11.08981886
46WNK11.06733002
47PRKD31.05635912
48NME11.04959749
49TIE11.04645778
50NTRK21.02904550
51ROCK11.02050839
52FGFR41.00557404
53MOS1.00403015
54CDC42BPA0.99113314
55ROCK20.95201912
56FGFR20.93080886
57CAMK2D0.92934329
58MARK20.92283358
59TAOK20.89886088
60PTK60.88892572
61MAPK120.88644488
62LATS20.87957729
63TBK10.84444719
64PDK30.83878080
65PDK40.83878080
66PIK3CG0.83018940
67KSR20.81864922
68MAP3K110.78587238
69MAP3K60.78287630
70ARAF0.77114648
71FER0.77026895
72PRKCH0.76370179
73MAP3K40.76175064
74SGK2230.73501903
75SGK4940.73501903
76RET0.73408124
77TGFBR20.73315292
78ABL20.72565117
79HIPK20.71898268
80STK380.70199321
81LIMK10.69184997
82CAMK1D0.68793103
83PRKAA10.68402343
84PAK20.68242490
85BMX0.66960377
86LRRK20.66689300
87PRKD20.66535339
88MAP3K130.65830828
89NEK10.65350536
90MAP3K10.64437643
91RPS6KA20.63641213
92TYRO30.63544527
93MTOR0.62360176
94PRKAA20.61755770
95IRAK20.61310325
96MAPK150.61049940
97PDGFRB0.59388246
98DAPK30.58227693
99PTK20.57485663
100CDK120.57314213
101RPS6KC10.56861783
102RPS6KL10.56861783
103MAP2K40.56144384
104ZAP700.56109604
105NEK90.54561115
106BCKDK0.54355709
107CAMK2A0.53936267
108CDK50.53894719
109PRKG20.52491560
110TRPM70.51396652
111CAMK40.50889353
112PRKCE0.50820534
113MAPKAPK50.50690638
114DYRK1B0.50166984
115CAMK2B0.49249272
116EEF2K0.49202121
117STK110.48385370
118ERBB20.48089386
119CAMK10.47640980
120CSK0.45037667
121MAPK130.44237197
122PRKACB0.44103460
123LATS10.42594034
124NTRK30.42483047
125CAMK2G0.42459024
126CAMKK10.41996293
127MAP2K20.41355013
128TNIK0.40993918
129PRKG10.40740716
130MAP3K20.40633175
131PNCK0.40583010
132EPHA30.40219429
133SGK10.40104238
134SGK30.39267392
135RPS6KA30.38012595
136PDPK10.37886020
137MAP2K10.37635115
138TAOK10.37146792
139RPS6KA60.35741196
140MAPKAPK20.34502543
141ERBB40.34445523
142SIK20.33975259
143MAP2K60.32281182
144MAPK70.31180326
145PTK2B0.30980136

Predicted pathways (KEGG)

RankGene SetZ-score
1Dilated cardiomyopathy_Homo sapiens_hsa054143.09608446
2Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054102.92964597
3Cardiac muscle contraction_Homo sapiens_hsa042602.61974278
4Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.59173970
5Other glycan degradation_Homo sapiens_hsa005112.39426348
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.17142690
7Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.12694832
8Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042612.02612827
9Glycosaminoglycan degradation_Homo sapiens_hsa005312.02237738
10Phototransduction_Homo sapiens_hsa047441.75740163
11Insulin secretion_Homo sapiens_hsa049111.57241029
12Circadian entrainment_Homo sapiens_hsa047131.48912283
13Lysosome_Homo sapiens_hsa041421.48830466
14Oxytocin signaling pathway_Homo sapiens_hsa049211.47293276
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.46957568
16Prion diseases_Homo sapiens_hsa050201.45974031
17Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.44702262
18Gastric acid secretion_Homo sapiens_hsa049711.43982343
19Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.39860898
20cGMP-PKG signaling pathway_Homo sapiens_hsa040221.39381011
21Bladder cancer_Homo sapiens_hsa052191.38765096
22Chronic myeloid leukemia_Homo sapiens_hsa052201.37296169
23Focal adhesion_Homo sapiens_hsa045101.35846382
24Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.34039530
25ECM-receptor interaction_Homo sapiens_hsa045121.29378813
26Renin secretion_Homo sapiens_hsa049241.29151454
27GABAergic synapse_Homo sapiens_hsa047271.28681780
28Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.28281133
29Type II diabetes mellitus_Homo sapiens_hsa049301.28076675
30Cholinergic synapse_Homo sapiens_hsa047251.27447401
31Axon guidance_Homo sapiens_hsa043601.25845552
32Aldosterone synthesis and secretion_Homo sapiens_hsa049251.24593994
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24429904
34Leukocyte transendothelial migration_Homo sapiens_hsa046701.23113806
35Vascular smooth muscle contraction_Homo sapiens_hsa042701.22122000
36Calcium signaling pathway_Homo sapiens_hsa040201.16018242
37Insulin signaling pathway_Homo sapiens_hsa049101.15756231
38Tight junction_Homo sapiens_hsa045301.15368620
39Insulin resistance_Homo sapiens_hsa049311.10911068
40Gap junction_Homo sapiens_hsa045401.09910795
41Glucagon signaling pathway_Homo sapiens_hsa049221.09802424
42Fructose and mannose metabolism_Homo sapiens_hsa000511.09326040
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.09096046
44Melanogenesis_Homo sapiens_hsa049161.08549441
45Pancreatic cancer_Homo sapiens_hsa052121.08092439
46Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07518027
47Viral myocarditis_Homo sapiens_hsa054161.07321180
48Morphine addiction_Homo sapiens_hsa050321.05796387
49AMPK signaling pathway_Homo sapiens_hsa041521.04796297
50Osteoclast differentiation_Homo sapiens_hsa043801.03272974
51Acute myeloid leukemia_Homo sapiens_hsa052211.02883972
52Salivary secretion_Homo sapiens_hsa049701.01615465
53Dopaminergic synapse_Homo sapiens_hsa047281.01121252
54Renal cell carcinoma_Homo sapiens_hsa052111.00739027
55Glutamatergic synapse_Homo sapiens_hsa047241.00443277
56Alzheimers disease_Homo sapiens_hsa050100.99485944
57GnRH signaling pathway_Homo sapiens_hsa049120.99343904
58Cocaine addiction_Homo sapiens_hsa050300.98836707
59Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98717073
60Non-small cell lung cancer_Homo sapiens_hsa052230.98563468
61Pentose phosphate pathway_Homo sapiens_hsa000300.97224803
62Endocytosis_Homo sapiens_hsa041440.97002129
63Basal cell carcinoma_Homo sapiens_hsa052170.96956627
64cAMP signaling pathway_Homo sapiens_hsa040240.95009934
65Salmonella infection_Homo sapiens_hsa051320.94877698
66Vibrio cholerae infection_Homo sapiens_hsa051100.93792337
67Hepatitis C_Homo sapiens_hsa051600.93778418
68Estrogen signaling pathway_Homo sapiens_hsa049150.92706166
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.92138775
70Hedgehog signaling pathway_Homo sapiens_hsa043400.91269093
71Parkinsons disease_Homo sapiens_hsa050120.90271162
72Galactose metabolism_Homo sapiens_hsa000520.90018358
73Toll-like receptor signaling pathway_Homo sapiens_hsa046200.89873242
74Dorso-ventral axis formation_Homo sapiens_hsa043200.89239975
75Longevity regulating pathway - mammal_Homo sapiens_hsa042110.89184065
76Taste transduction_Homo sapiens_hsa047420.88540173
77Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.85895379
78Small cell lung cancer_Homo sapiens_hsa052220.85490738
79Notch signaling pathway_Homo sapiens_hsa043300.85270773
80TNF signaling pathway_Homo sapiens_hsa046680.85174008
81Circadian rhythm_Homo sapiens_hsa047100.84900095
82Propanoate metabolism_Homo sapiens_hsa006400.84861656
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84370967
84Pancreatic secretion_Homo sapiens_hsa049720.84028498
85Olfactory transduction_Homo sapiens_hsa047400.84002136
86Serotonergic synapse_Homo sapiens_hsa047260.83457660
87Proteoglycans in cancer_Homo sapiens_hsa052050.82839930
88Long-term potentiation_Homo sapiens_hsa047200.82563951
89Adipocytokine signaling pathway_Homo sapiens_hsa049200.82552694
90Prolactin signaling pathway_Homo sapiens_hsa049170.81744409
91Sphingolipid signaling pathway_Homo sapiens_hsa040710.80657414
92Phenylalanine metabolism_Homo sapiens_hsa003600.78711951
93Long-term depression_Homo sapiens_hsa047300.78462089
94Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.78170099
95Thyroid hormone signaling pathway_Homo sapiens_hsa049190.77032742
96Protein digestion and absorption_Homo sapiens_hsa049740.76516177
97Choline metabolism in cancer_Homo sapiens_hsa052310.76314563
98Phospholipase D signaling pathway_Homo sapiens_hsa040720.75000554
99Glioma_Homo sapiens_hsa052140.74122062
100Amoebiasis_Homo sapiens_hsa051460.73119375
101Amphetamine addiction_Homo sapiens_hsa050310.73048770
102Oxidative phosphorylation_Homo sapiens_hsa001900.72964193
103Thyroid cancer_Homo sapiens_hsa052160.70759068
104Hippo signaling pathway_Homo sapiens_hsa043900.70703799
105Fatty acid metabolism_Homo sapiens_hsa012120.69359013
106Synaptic vesicle cycle_Homo sapiens_hsa047210.68822382
107Malaria_Homo sapiens_hsa051440.68790942
108Pertussis_Homo sapiens_hsa051330.68023899
109MAPK signaling pathway_Homo sapiens_hsa040100.67522186
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.66979121
111mTOR signaling pathway_Homo sapiens_hsa041500.66958783
112Prostate cancer_Homo sapiens_hsa052150.66178040
113Wnt signaling pathway_Homo sapiens_hsa043100.65875614
114Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.65151851
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.64666731
116Toxoplasmosis_Homo sapiens_hsa051450.64126531
117ErbB signaling pathway_Homo sapiens_hsa040120.64060967
118Sphingolipid metabolism_Homo sapiens_hsa006000.64052684
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62794126
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.62560391
121VEGF signaling pathway_Homo sapiens_hsa043700.62397471
122AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61540960
123Adherens junction_Homo sapiens_hsa045200.60894899
124Rap1 signaling pathway_Homo sapiens_hsa040150.60241872
125Shigellosis_Homo sapiens_hsa051310.59877709
126Nicotine addiction_Homo sapiens_hsa050330.59209988
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.58649536
128MicroRNAs in cancer_Homo sapiens_hsa052060.58401736
129Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.56934175
130Endometrial cancer_Homo sapiens_hsa052130.56446764
131Fatty acid degradation_Homo sapiens_hsa000710.56349336
132Pathways in cancer_Homo sapiens_hsa052000.56253764
133Ras signaling pathway_Homo sapiens_hsa040140.56106306
134Ovarian steroidogenesis_Homo sapiens_hsa049130.55699014
135Lysine degradation_Homo sapiens_hsa003100.54613110
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54179049
137Phagosome_Homo sapiens_hsa041450.54078152
138Thyroid hormone synthesis_Homo sapiens_hsa049180.53859677
139Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52777531
140Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52591394
141Phosphatidylinositol signaling system_Homo sapiens_hsa040700.52378510
142Neurotrophin signaling pathway_Homo sapiens_hsa047220.50880411
143HIF-1 signaling pathway_Homo sapiens_hsa040660.50519195
144Apoptosis_Homo sapiens_hsa042100.50455253
145Tuberculosis_Homo sapiens_hsa051520.50421489
146Histidine metabolism_Homo sapiens_hsa003400.50223176
147Inositol phosphate metabolism_Homo sapiens_hsa005620.50068337
148Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.49776587
149Carbohydrate digestion and absorption_Homo sapiens_hsa049730.49284999

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