CUL1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)6.08060358
2mitotic chromosome condensation (GO:0007076)5.61877086
3monoubiquitinated protein deubiquitination (GO:0035520)5.43212277
4regulation of attachment of spindle microtubules to kinetochore (GO:0051988)5.28973473
5metaphase plate congression (GO:0051310)5.20483227
6mitotic sister chromatid cohesion (GO:0007064)4.89703533
7regulation of sister chromatid cohesion (GO:0007063)4.84266961
8attachment of spindle microtubules to kinetochore (GO:0008608)4.84048925
9ribosome assembly (GO:0042255)4.80557320
10DNA strand elongation involved in DNA replication (GO:0006271)4.72412463
11regulation of spindle organization (GO:0090224)4.70527216
12protein localization to kinetochore (GO:0034501)4.69293809
13nuclear pore complex assembly (GO:0051292)4.66248026
14establishment of chromosome localization (GO:0051303)4.60401386
15DNA strand elongation (GO:0022616)4.56628434
16establishment of integrated proviral latency (GO:0075713)4.55868401
17nuclear pore organization (GO:0006999)4.52803903
18meiotic chromosome segregation (GO:0045132)4.50545764
19mitotic nuclear envelope disassembly (GO:0007077)4.49032865
20CENP-A containing nucleosome assembly (GO:0034080)4.32494884
21membrane disassembly (GO:0030397)4.30448050
22nuclear envelope disassembly (GO:0051081)4.30448050
23negative regulation of retinoic acid receptor signaling pathway (GO:0048387)4.29497039
24protein localization to chromosome, centromeric region (GO:0071459)4.24166095
25chromatin remodeling at centromere (GO:0031055)4.22134746
26histone H2A monoubiquitination (GO:0035518)4.21997054
27positive regulation of chromosome segregation (GO:0051984)4.09235466
28maturation of 5.8S rRNA (GO:0000460)4.08651979
29histone exchange (GO:0043486)4.08083669
30mitotic sister chromatid segregation (GO:0000070)4.05325348
31DNA replication-independent nucleosome assembly (GO:0006336)4.05195466
32DNA replication-independent nucleosome organization (GO:0034724)4.05195466
33spindle checkpoint (GO:0031577)4.03436514
34regulation of mitotic spindle organization (GO:0060236)4.03291376
35protein localization to chromosome (GO:0034502)4.02612839
36regulation of meiosis I (GO:0060631)4.01329619
37regulation of chromosome segregation (GO:0051983)4.00196145
38IMP metabolic process (GO:0046040)3.92826760
39positive regulation of mitotic sister chromatid separation (GO:1901970)3.91190331
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.91190331
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.91190331
42DNA replication checkpoint (GO:0000076)3.90975494
43IMP biosynthetic process (GO:0006188)3.86704754
44piRNA metabolic process (GO:0034587)3.84635749
45sister chromatid segregation (GO:0000819)3.84241145
46formation of translation preinitiation complex (GO:0001731)3.82412833
47establishment of viral latency (GO:0019043)3.82055161
48DNA damage induced protein phosphorylation (GO:0006975)3.80464702
49telomere maintenance via semi-conservative replication (GO:0032201)3.80033021
50negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.79888043
51regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.79444490
52chromosome segregation (GO:0007059)3.75813415
53regulation of centriole replication (GO:0046599)3.71217423
54mitotic spindle checkpoint (GO:0071174)3.69258248
55regulation of meiosis (GO:0040020)3.66646122
56sister chromatid cohesion (GO:0007062)3.62056338
57regulation of mitotic metaphase/anaphase transition (GO:0030071)3.60587860
58kinetochore organization (GO:0051383)3.58338810
59regulation of exit from mitosis (GO:0007096)3.56793026
60mitotic spindle assembly checkpoint (GO:0007094)3.55765302
61negative regulation of mitotic sister chromatid separation (GO:2000816)3.55330725
62negative regulation of mitotic sister chromatid segregation (GO:0033048)3.55330725
63negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.55330725
64negative regulation of sister chromatid segregation (GO:0033046)3.55330725
65negative regulation of chromosome segregation (GO:0051985)3.54569632
66female gamete generation (GO:0007292)3.54484575
67non-recombinational repair (GO:0000726)3.53406166
68double-strand break repair via nonhomologous end joining (GO:0006303)3.53406166
69spindle assembly checkpoint (GO:0071173)3.52655719
70meiotic cell cycle (GO:0051321)3.51987762
71DNA unwinding involved in DNA replication (GO:0006268)3.49457152
72negative regulation of meiosis (GO:0045835)3.49326808
73DNA duplex unwinding (GO:0032508)3.48245490
74DNA replication initiation (GO:0006270)3.47964839
75regulation of centrosome cycle (GO:0046605)3.47372447
76DNA damage response, signal transduction resulting in transcription (GO:0042772)3.46864426
77regulation of mitotic sister chromatid separation (GO:0010965)3.46781723
78regulation of mitotic sister chromatid segregation (GO:0033047)3.46781723
79regulation of sister chromatid segregation (GO:0033045)3.46781723
80nuclear envelope organization (GO:0006998)3.46643779
81DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.44944903
82chromatin assembly or disassembly (GO:0006333)3.44453069
83protein complex localization (GO:0031503)3.44168699
84cellular protein complex localization (GO:0034629)3.41906990
85DNA replication-dependent nucleosome assembly (GO:0006335)3.39513216
86DNA replication-dependent nucleosome organization (GO:0034723)3.39513216
87negative regulation of histone methylation (GO:0031061)3.39396810
88histone H2A ubiquitination (GO:0033522)3.35482417
89oocyte maturation (GO:0001556)3.35450415
90regulation of retinoic acid receptor signaling pathway (GO:0048385)3.34163608
91DNA geometric change (GO:0032392)3.33425229
92protein K6-linked ubiquitination (GO:0085020)3.32280030
93DNA packaging (GO:0006323)3.31724314
94pore complex assembly (GO:0046931)3.30905351
95DNA topological change (GO:0006265)3.28812161
96regulation of nucleobase-containing compound transport (GO:0032239)3.27604871
97gene silencing by RNA (GO:0031047)3.24808126
98regulation of female gonad development (GO:2000194)3.24171282
99DNA conformation change (GO:0071103)3.23896005
100regulation of RNA export from nucleus (GO:0046831)3.23295674
101negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.21663241
102regulation of translational fidelity (GO:0006450)3.19548380
103tRNA aminoacylation for protein translation (GO:0006418)3.18922200
104DNA ligation (GO:0006266)3.18561108
105telomere maintenance via recombination (GO:0000722)3.17447117
106folic acid-containing compound biosynthetic process (GO:0009396)3.17168325
107mitotic recombination (GO:0006312)3.17046234
108ATP-dependent chromatin remodeling (GO:0043044)3.16781563
109regulation of transforming growth factor beta2 production (GO:0032909)3.11176713
110kinetochore assembly (GO:0051382)3.11093380
111male meiosis (GO:0007140)3.11085212
112snRNA transcription (GO:0009301)3.10381401
113chromosome condensation (GO:0030261)3.09127091
114spliceosomal tri-snRNP complex assembly (GO:0000244)3.08132347
115regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.08025408
116purine nucleobase biosynthetic process (GO:0009113)3.05395202
117amino acid activation (GO:0043038)3.03127971
118tRNA aminoacylation (GO:0043039)3.03127971
119nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)3.01295966
120binding of sperm to zona pellucida (GO:0007339)3.01108790
121positive regulation of DNA-dependent DNA replication (GO:2000105)3.00334912
122peptidyl-arginine omega-N-methylation (GO:0035247)2.99949033
123regulation of telomere maintenance via telomerase (GO:0032210)2.98569108
124negative regulation of nuclear division (GO:0051784)2.97971389
125resolution of meiotic recombination intermediates (GO:0000712)2.96055271
126negative regulation of mitosis (GO:0045839)2.95488519
127meiotic cell cycle process (GO:1903046)2.94117806
128synaptonemal complex assembly (GO:0007130)2.93912872
129paraxial mesoderm development (GO:0048339)2.93598002
130pre-miRNA processing (GO:0031054)2.92814618
131protein export from nucleus (GO:0006611)2.91946674
132telomere maintenance via telomere lengthening (GO:0010833)2.90935775
133regulation of histone H3-K9 methylation (GO:0051570)2.90316536
134heterochromatin organization (GO:0070828)2.89828827
135nucleotide-excision repair, DNA gap filling (GO:0006297)2.89291822
136negative regulation of mRNA processing (GO:0050686)2.86498501
137COPI coating of Golgi vesicle (GO:0048205)2.84593032
138Golgi transport vesicle coating (GO:0048200)2.84593032
139regulation of double-strand break repair via homologous recombination (GO:0010569)2.84365506
140regulation of DNA endoreduplication (GO:0032875)2.79788416
141mRNA transport (GO:0051028)2.79708280
142histone H2B ubiquitination (GO:0033523)2.79484520
143RNA-dependent DNA replication (GO:0006278)2.76005987
144ribosome biogenesis (GO:0042254)2.75458092
145DNA synthesis involved in DNA repair (GO:0000731)2.73128398

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.72463574
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.21425877
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.39156525
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.32335063
5AR_21909140_ChIP-Seq_LNCAP_Human4.22339133
6SALL1_21062744_ChIP-ChIP_HESCs_Human4.01488562
7* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.48865317
8RBPJ_22232070_ChIP-Seq_NCS_Mouse2.97058133
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.81787994
10E2F1_21310950_ChIP-Seq_MCF-7_Human2.81618790
11MYC_18555785_ChIP-Seq_MESCs_Mouse2.55438205
12PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.29223231
13MYCN_18555785_ChIP-Seq_MESCs_Mouse2.20679575
14* PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.13502029
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.11411861
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.11223175
17THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01693734
18NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.01565529
19KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.88728279
20* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.83203377
21MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76328793
22* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.70037465
23TP63_19390658_ChIP-ChIP_HaCaT_Human1.69593648
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.67583091
25STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.67291708
26CREB1_15753290_ChIP-ChIP_HEK293T_Human1.65316814
27EGR1_19374776_ChIP-ChIP_THP-1_Human1.63301619
28HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.62842860
29* SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.60009216
30YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.58430861
31NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.57633858
32ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54352331
33* SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.50289868
34GABP_17652178_ChIP-ChIP_JURKAT_Human1.49898361
35KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49687302
36MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.47704150
37KDM5A_27292631_Chip-Seq_BREAST_Human1.44700144
38E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.44427800
39MYC_19079543_ChIP-ChIP_MESCs_Mouse1.43875911
40* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.43641000
41* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.43372623
42EST1_17652178_ChIP-ChIP_JURKAT_Human1.41891758
43GABP_19822575_ChIP-Seq_HepG2_Human1.40700992
44CLOCK_20551151_ChIP-Seq_293T_Human1.39673115
45KLF4_18555785_ChIP-Seq_MESCs_Mouse1.39541197
46BP1_19119308_ChIP-ChIP_Hs578T_Human1.36282405
47CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.31439997
48ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31129906
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.28490175
50XRN2_22483619_ChIP-Seq_HELA_Human1.28147273
51VDR_23849224_ChIP-Seq_CD4+_Human1.27397113
52DCP1A_22483619_ChIP-Seq_HELA_Human1.25202177
53EWS_26573619_Chip-Seq_HEK293_Human1.24157461
54PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24057048
55* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.22617951
56CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.22255449
57MYC_18940864_ChIP-ChIP_HL60_Human1.21959330
58ETS1_20019798_ChIP-Seq_JURKAT_Human1.21024991
59ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.20337833
60MYC_18358816_ChIP-ChIP_MESCs_Mouse1.18576916
61FUS_26573619_Chip-Seq_HEK293_Human1.17770093
62DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.17116108
63SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.17082082
64E2F1_18555785_ChIP-Seq_MESCs_Mouse1.16554741
65HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14868425
66GATA1_26923725_Chip-Seq_HPCs_Mouse1.13170847
67NANOG_21062744_ChIP-ChIP_HESCs_Human1.12823154
68KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.08996876
69KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.08996876
70KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.08996876
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.08804386
72DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08610542
73STAT3_1855785_ChIP-Seq_MESCs_Mouse1.07246029
74* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07127645
75POU3F2_20337985_ChIP-ChIP_501MEL_Human1.07007576
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.07002290
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.06979666
78CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.06088553
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.05023843
80NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.04167581
81TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04156924
82BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.03598912
83NANOG_18555785_ChIP-Seq_MESCs_Mouse1.01922158
84ELK1_19687146_ChIP-ChIP_HELA_Human1.01666403
85POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.01643053
86FOXP3_21729870_ChIP-Seq_TREG_Human0.99550551
87ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98435093
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97942673
89FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.97249572
90* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.97205738
91CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96965776
92CIITA_25753668_ChIP-Seq_RAJI_Human0.96642080
93CHD1_26751641_Chip-Seq_LNCaP_Human0.96591551
94BRD4_25478319_ChIP-Seq_HGPS_Human0.96357878
95SOX17_20123909_ChIP-Seq_XEN_Mouse0.95845233
96TTF2_22483619_ChIP-Seq_HELA_Human0.94393065
97PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94151113
98CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.93833103
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91641362
100PKCTHETA_26484144_Chip-Seq_BREAST_Human0.91529672
101MEF2A_21415370_ChIP-Seq_HL-1_Mouse0.91340450
102SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91216505
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90466527
104CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90362451
105POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89282330
106E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.89020668
107RUNX1_26923725_Chip-Seq_HPCs_Mouse0.88527809
108* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.88343900
109FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.87622313
110SRF_21415370_ChIP-Seq_HL-1_Mouse0.87425158
111FLI1_27457419_Chip-Seq_LIVER_Mouse0.85786135
112BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84965123
113TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.83976671
114TBX5_21415370_ChIP-Seq_HL-1_Mouse0.83329063
115CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.83156101
116* MYC_22102868_ChIP-Seq_BL_Human0.82406917
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.80851242
118YY1_21170310_ChIP-Seq_MESCs_Mouse0.80714200
119TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.79838263
120HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.79547196
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.78516784
122HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.78288796
123EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.76594396
124SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.75248364
125NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.74479375
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.70821616
127TFEB_21752829_ChIP-Seq_HELA_Human0.68174482
128ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.67876962
129POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.67855610
130LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.66786387

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.26484005
2MP0010094_abnormal_chromosome_stability3.95883019
3MP0003077_abnormal_cell_cycle3.50934472
4MP0003111_abnormal_nucleus_morphology3.46420170
5MP0003123_paternal_imprinting3.46221085
6MP0004957_abnormal_blastocyst_morpholog3.44421225
7MP0008877_abnormal_DNA_methylation3.16598145
8MP0003718_maternal_effect3.02848196
9MP0003941_abnormal_skin_development2.80985412
10MP0008057_abnormal_DNA_replication2.70719068
11MP0008007_abnormal_cellular_replicative2.62168676
12MP0003121_genomic_imprinting2.50267219
13MP0002102_abnormal_ear_morphology2.49823904
14MP0001730_embryonic_growth_arrest2.48960929
15MP0005451_abnormal_body_composition2.48659877
16MP0002653_abnormal_ependyma_morphology2.41752281
17MP0008932_abnormal_embryonic_tissue2.20408803
18MP0000350_abnormal_cell_proliferation2.05312907
19MP0003937_abnormal_limbs/digits/tail_de2.01024312
20MP0008260_abnormal_autophagy1.98461331
21MP0008058_abnormal_DNA_repair1.97454510
22MP0005408_hypopigmentation1.93970396
23MP0005380_embryogenesis_phenotype1.88623028
24MP0001672_abnormal_embryogenesis/_devel1.88623028
25* MP0001697_abnormal_embryo_size1.88101282
26* MP0002085_abnormal_embryonic_tissue1.81430218
27MP0010307_abnormal_tumor_latency1.81364918
28* MP0002084_abnormal_developmental_patter1.80425417
29MP0003890_abnormal_embryonic-extraembry1.72183836
30MP0003984_embryonic_growth_retardation1.68920819
31MP0001119_abnormal_female_reproductive1.65591767
32MP0002210_abnormal_sex_determination1.64205519
33MP0002088_abnormal_embryonic_growth/wei1.63816156
34MP0001929_abnormal_gametogenesis1.62652193
35MP0001915_intracranial_hemorrhage1.61414751
36MP0010352_gastrointestinal_tract_polyps1.55220197
37MP0000653_abnormal_sex_gland1.53913133
38MP0010030_abnormal_orbit_morphology1.52802705
39MP0010234_abnormal_vibrissa_follicle1.51116255
40MP0003787_abnormal_imprinting1.48541177
41MP0003699_abnormal_female_reproductive1.48386715
42MP0002086_abnormal_extraembryonic_tissu1.47211226
43MP0010368_abnormal_lymphatic_system1.43815608
44MP0000751_myopathy1.43516301
45MP0004264_abnormal_extraembryonic_tissu1.41218984
46* MP0002080_prenatal_lethality1.38259042
47MP0003646_muscle_fatigue1.38025658
48MP0002269_muscular_atrophy1.37290074
49MP0005076_abnormal_cell_differentiation1.35712732
50MP0000358_abnormal_cell_content/1.35669444
51MP0000537_abnormal_urethra_morphology1.32853949
52MP0000747_muscle_weakness1.31086464
53MP0000749_muscle_degeneration1.30357049
54MP0003806_abnormal_nucleotide_metabolis1.30156578
55MP0006035_abnormal_mitochondrial_morpho1.28089689
56MP0001145_abnormal_male_reproductive1.26878054
57MP0003567_abnormal_fetal_cardiomyocyte1.26567097
58MP0004197_abnormal_fetal_growth/weight/1.21558476
59MP0006054_spinal_hemorrhage1.20514432
60MP0002396_abnormal_hematopoietic_system1.19829921
61MP0003705_abnormal_hypodermis_morpholog1.16771110
62MP0003221_abnormal_cardiomyocyte_apopto1.15356806
63MP0001853_heart_inflammation1.14865235
64MP0005623_abnormal_meninges_morphology1.11580577
65MP0000733_abnormal_muscle_development1.09426336
66MP0005187_abnormal_penis_morphology1.07999917
67MP0004185_abnormal_adipocyte_glucose1.04945203
68MP0002877_abnormal_melanocyte_morpholog1.04217425
69MP0002332_abnormal_exercise_endurance1.03317360
70MP0003755_abnormal_palate_morphology1.02753000
71MP0001849_ear_inflammation1.02729080
72MP0003935_abnormal_craniofacial_develop1.02551520
73* MP0005395_other_phenotype1.02153644
74MP0003656_abnormal_erythrocyte_physiolo1.01462337
75MP0009697_abnormal_copulation1.00356487
76MP0004087_abnormal_muscle_fiber0.98757188
77MP0000428_abnormal_craniofacial_morphol0.97974763
78MP0009672_abnormal_birth_weight0.97274095
79MP0002161_abnormal_fertility/fecundity0.96330428
80MP0001188_hyperpigmentation0.95883144
81MP0003119_abnormal_digestive_system0.95820164
82MP0003186_abnormal_redox_activity0.95364030
83MP0005248_abnormal_Harderian_gland0.95037335
84MP0000759_abnormal_skeletal_muscle0.94927347
85MP0003453_abnormal_keratinocyte_physiol0.94362061
86MP0000569_abnormal_digit_pigmentation0.93916029
87MP0009053_abnormal_anal_canal0.92998279
88MP0002796_impaired_skin_barrier0.90549416
89MP0003315_abnormal_perineum_morphology0.90029278
90MP0004808_abnormal_hematopoietic_stem0.89292425
91MP0002019_abnormal_tumor_incidence0.89142267
92MP0005501_abnormal_skin_physiology0.88590741
93MP0008789_abnormal_olfactory_epithelium0.87663190
94MP0009250_abnormal_appendicular_skeleto0.87619195
95MP0002932_abnormal_joint_morphology0.87558521
96MP0000490_abnormal_crypts_of0.87133117
97MP0002925_abnormal_cardiovascular_devel0.85628130
98MP0005621_abnormal_cell_physiology0.85385178
99MP0006292_abnormal_olfactory_placode0.85254587
100MP0002249_abnormal_larynx_morphology0.85083993
101MP0004145_abnormal_muscle_electrophysio0.84357288
102MP0003861_abnormal_nervous_system0.83686057
103MP0000313_abnormal_cell_death0.83445029
104MP0003115_abnormal_respiratory_system0.83430765
105MP0006036_abnormal_mitochondrial_physio0.81513776
106MP0000432_abnormal_head_morphology0.81386567
107MP0001661_extended_life_span0.80052933
108MP0003566_abnormal_cell_adhesion0.79947957
109MP0003943_abnormal_hepatobiliary_system0.79663912
110MP0001293_anophthalmia0.79152628
111MP0001727_abnormal_embryo_implantation0.78740721
112MP0005384_cellular_phenotype0.78237210
113MP0000534_abnormal_ureter_morphology0.78012343
114MP0004233_abnormal_muscle_weight0.78011182
115MP0009703_decreased_birth_body0.77471735
116MP0003385_abnormal_body_wall0.77135215
117MP0005266_abnormal_metabolism0.76543833
118MP0004084_abnormal_cardiac_muscle0.75426842
119MP0003942_abnormal_urinary_system0.74151444
120MP0003950_abnormal_plasma_membrane0.73812659
121MP0003786_premature_aging0.73343926
122MP0010630_abnormal_cardiac_muscle0.72755571
123MP0005330_cardiomyopathy0.71410336
124MP0002160_abnormal_reproductive_system0.71230199
125MP0002111_abnormal_tail_morphology0.71190736
126MP0005257_abnormal_intraocular_pressure0.70261141
127MP0005499_abnormal_olfactory_system0.70006513
128MP0005394_taste/olfaction_phenotype0.70006513
129MP0003698_abnormal_male_reproductive0.69997146
130MP0002233_abnormal_nose_morphology0.69484296
131MP0005058_abnormal_lysosome_morphology0.69345272
132MP0000462_abnormal_digestive_system0.68910999
133MP0000266_abnormal_heart_morphology0.68345672
134MP0003448_altered_tumor_morphology0.67878283
135MP0002092_abnormal_eye_morphology0.66942404
136MP0000579_abnormal_nail_morphology0.66069245
137MP0002697_abnormal_eye_size0.61111202
138MP0002060_abnormal_skin_morphology0.60473598

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)4.86377919
2Birth length less than 3rd percentile (HP:0003561)4.48307491
3Chromsome breakage (HP:0040012)4.16930744
4Male infertility (HP:0003251)3.92554937
5Facial hemangioma (HP:0000329)3.79064707
6Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69942187
7Abnormality of the labia minora (HP:0012880)3.63535806
8Shoulder girdle muscle weakness (HP:0003547)3.58236698
9Cholecystitis (HP:0001082)3.57710178
10Abnormal gallbladder physiology (HP:0012438)3.57710178
11Breast hypoplasia (HP:0003187)3.52001403
12Patellar aplasia (HP:0006443)3.50061166
13Capillary hemangiomas (HP:0005306)3.36711866
14Aplasia/Hypoplasia of the patella (HP:0006498)3.24138565
15Abnormality of chromosome stability (HP:0003220)3.21384522
16Shawl scrotum (HP:0000049)3.14604864
17Volvulus (HP:0002580)3.06206887
18Abnormality of glycolysis (HP:0004366)2.96402444
19Thyroid carcinoma (HP:0002890)2.95808230
20Termporal pattern (HP:0011008)2.90514879
21Insidious onset (HP:0003587)2.90514879
22Progressive external ophthalmoplegia (HP:0000590)2.90424918
23Progressive muscle weakness (HP:0003323)2.86979356
24Acute myeloid leukemia (HP:0004808)2.83633901
25Nemaline bodies (HP:0003798)2.79399237
26Abnormality of the hip-girdle musculature (HP:0001445)2.74407511
27Abnormality of the musculature of the pelvis (HP:0001469)2.74407511
28Aplasia/Hypoplasia of the uvula (HP:0010293)2.72834090
29Meckel diverticulum (HP:0002245)2.71885585
30Exercise-induced muscle cramps (HP:0003710)2.67569327
31Sandal gap (HP:0001852)2.65847899
32Abnormality of the fingertips (HP:0001211)2.65540276
33Multiple enchondromatosis (HP:0005701)2.64031670
34Increased serum pyruvate (HP:0003542)2.63908998
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.62090283
36Short 4th metacarpal (HP:0010044)2.62090283
37Rimmed vacuoles (HP:0003805)2.59629719
38Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.58806510
39Aplasia/Hypoplasia of the sternum (HP:0006714)2.57387376
40Muscle fiber inclusion bodies (HP:0100299)2.54559952
41Resting tremor (HP:0002322)2.50556279
42Abnormality of the ileum (HP:0001549)2.49052043
43Microglossia (HP:0000171)2.47012589
44Adrenal hypoplasia (HP:0000835)2.40489493
45Ankle contracture (HP:0006466)2.39511086
46Subacute progressive viral hepatitis (HP:0006572)2.38631993
47Wrist flexion contracture (HP:0001239)2.38369885
48Carpal bone hypoplasia (HP:0001498)2.38316404
49Spastic diplegia (HP:0001264)2.38266975
50Microvesicular hepatic steatosis (HP:0001414)2.37972743
51Duodenal stenosis (HP:0100867)2.35347527
52Small intestinal stenosis (HP:0012848)2.35347527
53Ectopic kidney (HP:0000086)2.35116830
54Rhabdomyosarcoma (HP:0002859)2.35032373
55Flat capital femoral epiphysis (HP:0003370)2.34570467
56Abnormality of the preputium (HP:0100587)2.33224489
57Medulloblastoma (HP:0002885)2.29456757
58Breast aplasia (HP:0100783)2.26622678
59Centrally nucleated skeletal muscle fibers (HP:0003687)2.26337784
60Myelodysplasia (HP:0002863)2.25736913
61Enlarged penis (HP:0000040)2.22422309
62Cafe-au-lait spot (HP:0000957)2.22396502
63Calcaneovalgus deformity (HP:0001848)2.20837649
64Shallow orbits (HP:0000586)2.19707603
65Supernumerary spleens (HP:0009799)2.19465863
66Cortical dysplasia (HP:0002539)2.17676397
67Upper motor neuron abnormality (HP:0002127)2.17600306
68Abnormality of chromosome segregation (HP:0002916)2.17497919
69Ragged-red muscle fibers (HP:0003200)2.16745698
70Aplasia/Hypoplasia of the breasts (HP:0010311)2.15125942
71Heterotopia (HP:0002282)2.15091599
72Exercise-induced myalgia (HP:0003738)2.14588021
73Oligodactyly (HP:0012165)2.12364547
74Deep philtrum (HP:0002002)2.06725064
75Absent radius (HP:0003974)2.06130853
76Sloping forehead (HP:0000340)2.05875583
77Oral leukoplakia (HP:0002745)2.05018962
78Secondary amenorrhea (HP:0000869)2.02414968
79Embryonal renal neoplasm (HP:0011794)2.02324941
80Overlapping toe (HP:0001845)2.01947999
81Abnormality of lateral ventricle (HP:0030047)2.01107829
82Nephroblastoma (Wilms tumor) (HP:0002667)2.00887771
83Facial cleft (HP:0002006)2.00398408
84Increased nuchal translucency (HP:0010880)2.00388384
85Abnormality of the calcaneus (HP:0008364)1.99777980
86Deformed tarsal bones (HP:0008119)1.99658050
87Arterial tortuosity (HP:0005116)1.99320637
88Abnormality of the carotid arteries (HP:0005344)1.98538538
89Embryonal neoplasm (HP:0002898)1.97657889
90Insomnia (HP:0100785)1.96108927
91Atresia of the external auditory canal (HP:0000413)1.94554722
92Hypoplasia of the capital femoral epiphysis (HP:0003090)1.94055137
93High pitched voice (HP:0001620)1.94041813
94Abnormal lung lobation (HP:0002101)1.93891376
95Colon cancer (HP:0003003)1.92923227
96Neoplasm of the oral cavity (HP:0100649)1.91166649
97Abnormality of the duodenum (HP:0002246)1.89698420
98Abnormality of the 4th metacarpal (HP:0010012)1.89483263
99Absent forearm bone (HP:0003953)1.89275559
100Aplasia involving forearm bones (HP:0009822)1.89275559
101Premature ovarian failure (HP:0008209)1.89044884
102Vascular tortuosity (HP:0004948)1.88055671
103Abnormality of the anterior horn cell (HP:0006802)1.87730398
104Degeneration of anterior horn cells (HP:0002398)1.87730398
105Abnormality of the left ventricular outflow tract (HP:0011103)1.86819493
106Subaortic stenosis (HP:0001682)1.86819493
107Deviation of the thumb (HP:0009603)1.86000725
108Abnormality of the salivary glands (HP:0010286)1.84999639
109Long clavicles (HP:0000890)1.83600755
110Postnatal microcephaly (HP:0005484)1.83520265
111Oligodactyly (hands) (HP:0001180)1.82863254
112Rib fusion (HP:0000902)1.82385882
113Diastasis recti (HP:0001540)1.82318286
114Gastrointestinal carcinoma (HP:0002672)1.81938433
115Malignant gastrointestinal tract tumors (HP:0006749)1.81938433
116Selective tooth agenesis (HP:0001592)1.80857199
117Narrow face (HP:0000275)1.80675815
118Posterior subcapsular cataract (HP:0007787)1.79774492
119Transitional cell carcinoma of the bladder (HP:0006740)1.78875980
120Slender long bone (HP:0003100)1.77873345
121Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.76541939
122Limb-girdle muscle weakness (HP:0003325)1.75870688
123Impulsivity (HP:0100710)1.75769788
124Abnormalities of placenta or umbilical cord (HP:0001194)1.75306182
125Uterine leiomyosarcoma (HP:0002891)1.75111599
126Leiomyosarcoma (HP:0100243)1.75111599
127Cerebral hypomyelination (HP:0006808)1.74494875
128Short thumb (HP:0009778)1.73973164
129Achilles tendon contracture (HP:0001771)1.72883693
130Hypoplastic labia majora (HP:0000059)1.72879166
131Cholelithiasis (HP:0001081)1.72813623
132Limb-girdle muscle atrophy (HP:0003797)1.72482954
133Neoplasm of the small intestine (HP:0100833)1.72313750
134Proximal placement of thumb (HP:0009623)1.72257707
135Abnormality of the labia majora (HP:0012881)1.72164128
136Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.70004947
137Subcapsular cataract (HP:0000523)1.69767035
138Abnormal spermatogenesis (HP:0008669)1.69441815
139Overriding aorta (HP:0002623)1.69276369
140Long eyelashes (HP:0000527)1.68564997
141Neoplasm of striated muscle (HP:0009728)1.67648960
142Abnormal hair whorl (HP:0010721)1.66958294
143Reduced antithrombin III activity (HP:0001976)1.66747467
144Abnormality of the proximal phalanges of the hand (HP:0009834)1.65742671
145Abnormality of the phalanges of the hallux (HP:0010057)1.65402578
146Rhabdomyolysis (HP:0003201)1.65331828
147Neoplasm of the colon (HP:0100273)1.64995017
148Pelvic girdle muscle weakness (HP:0003749)1.64124355
149Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.63852630
150Amniotic constriction ring (HP:0009775)1.63663781
151Abnormality of placental membranes (HP:0011409)1.63663781
152Microtia (HP:0008551)1.62748467
153Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.62644843
154Agnosia (HP:0010524)1.62597126
155Midline defect of the nose (HP:0004122)1.62546872
156Myoglobinuria (HP:0002913)1.61986979
157Intrahepatic cholestasis (HP:0001406)1.60411034
158Ependymoma (HP:0002888)1.59504304
159Lower limb hyperreflexia (HP:0002395)1.59306977
160IgA deficiency (HP:0002720)1.58915776
161Long palpebral fissure (HP:0000637)1.57306187

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.46229889
2LATS13.73203409
3PLK43.42202193
4LATS23.31290976
5ACVR1B3.02981754
6STK38L2.91873048
7TTK2.86731851
8PBK2.63207752
9NEK22.43010374
10KSR22.41395375
11MAP3K62.41140009
12EEF2K2.12637397
13WEE12.05851480
14ERBB42.04180450
15MOS1.96978102
16RAF11.87537749
17STK31.81590612
18BUB11.79784038
19KSR11.73180403
20MAP3K101.70075317
21NEK11.70053813
22NME21.69286181
23PLK11.66988573
24MELK1.64393277
25BRAF1.64261933
26BRD41.63452189
27EIF2AK11.60841838
28BRSK21.60616146
29CHEK21.59729806
30IRAK31.58027985
31PLK31.51241347
32SRPK11.44809780
33TRIM281.44131689
34TAOK31.42345120
35MAP3K91.38257332
36PIM21.29075092
37AURKB1.27832609
38PRKD31.27471439
39ALK1.20609938
40MAP3K81.15054897
41BRSK11.14770912
42TAOK11.14221912
43DYRK21.11533369
44CDK81.10772738
45CLK11.10625698
46STK101.09106720
47CDK91.07274777
48BMPR21.06707906
49PDK21.04551896
50ICK1.03006033
51SMG11.00871797
52TGFBR11.00512788
53CHEK10.99799575
54FRK0.96237787
55CSNK1G10.95867006
56MUSK0.95286901
57PAK60.94868576
58MKNK10.94568549
59ATR0.94296252
60RPS6KA40.93672386
61MAP3K120.92266622
62ATM0.88607724
63MAP3K40.88384729
64TTN0.87609836
65RPS6KB20.87550141
66CCNB10.86352584
67CDK140.85837834
68TYRO30.84369471
69PNCK0.81654906
70MAP3K130.80575628
71EIF2AK20.80041417
72AURKA0.79757053
73ARAF0.79156500
74CSNK1G30.77701912
75CDK180.77462554
76CDK70.76272459
77CDK150.73171770
78CDK11A0.71327397
79CDK40.70074468
80SIK30.69932131
81NEK90.69458840
82CDK120.69245401
83CSNK1A1L0.67973649
84MAP3K140.67650387
85NEK60.67399486
86MAPKAPK30.66689716
87CSNK1G20.66544133
88NUAK10.63362120
89CDK20.63265834
90PKN20.63053188
91TSSK60.62835653
92CDK190.62690531
93MST40.61054348
94OBSCN0.60903048
95GRK70.60315685
96CDK10.60089926
97SCYL20.59013162
98TRPM70.56878094
99RET0.56690071
100MAP2K40.55523698
101PRPF4B0.54692176
102DMPK0.53702239
103STK240.53413352
104MAP3K50.53007178
105CSNK1E0.52444492
106DAPK10.51849925
107DYRK30.51057455
108CAMK1G0.50475598
109RIPK10.49742814
110CDK60.49730013
111TESK10.47095625
112PASK0.46405984
113PDGFRA0.41626081
114STK380.41255772
115MTOR0.40399827
116PAK40.40081294
117PRKDC0.39990821
118PDK30.39077735
119PDK40.39077735
120MINK10.39015194
121FGFR10.38400029
122MST1R0.38353232
123ABL20.37374384
124PRKAA10.37106831
125BMPR1B0.36893753
126VRK10.36465317
127MKNK20.34221132
128SGK20.33847292
129STK40.33789926
130PAK10.32718583
131ERBB30.32689265
132EIF2AK30.32514881
133MAPKAPK50.32191423
134BCR0.31643875
135MAP2K10.31598259
136PLK20.30315592
137FGFR20.29902656

Predicted pathways (KEGG)

RankGene SetZ-score
1* Cell cycle_Homo sapiens_hsa041104.41469604
2DNA replication_Homo sapiens_hsa030303.30492558
3RNA transport_Homo sapiens_hsa030133.10164810
4Basal transcription factors_Homo sapiens_hsa030223.08182647
5RNA degradation_Homo sapiens_hsa030183.03001982
6Mismatch repair_Homo sapiens_hsa034302.87061479
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.78165881
8Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.77499885
9Homologous recombination_Homo sapiens_hsa034402.42857210
10Progesterone-mediated oocyte maturation_Homo sapiens_hsa049142.37907407
11Nucleotide excision repair_Homo sapiens_hsa034202.34037559
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.32602820
13Fanconi anemia pathway_Homo sapiens_hsa034602.30501661
14Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.26073372
15* Oocyte meiosis_Homo sapiens_hsa041142.21399980
16Base excision repair_Homo sapiens_hsa034102.20224087
17RNA polymerase_Homo sapiens_hsa030202.11603110
18mRNA surveillance pathway_Homo sapiens_hsa030152.10326857
19p53 signaling pathway_Homo sapiens_hsa041152.06303685
20Vitamin B6 metabolism_Homo sapiens_hsa007501.94735128
21Spliceosome_Homo sapiens_hsa030401.90556219
22Non-homologous end-joining_Homo sapiens_hsa034501.86652833
23Carbon metabolism_Homo sapiens_hsa012001.86273402
24* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.72461279
25MicroRNAs in cancer_Homo sapiens_hsa052061.63746819
26* TGF-beta signaling pathway_Homo sapiens_hsa043501.61256670
27Pancreatic cancer_Homo sapiens_hsa052121.53479495
28Thyroid cancer_Homo sapiens_hsa052161.51710559
29Ovarian steroidogenesis_Homo sapiens_hsa049131.51142306
30Adherens junction_Homo sapiens_hsa045201.43831625
31One carbon pool by folate_Homo sapiens_hsa006701.43773803
32Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.42418884
33Colorectal cancer_Homo sapiens_hsa052101.39183408
34Hippo signaling pathway_Homo sapiens_hsa043901.37959196
35Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.29761117
36Pyrimidine metabolism_Homo sapiens_hsa002401.25866007
37Pyruvate metabolism_Homo sapiens_hsa006201.23785488
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18425617
39Small cell lung cancer_Homo sapiens_hsa052221.12063387
40Fatty acid elongation_Homo sapiens_hsa000621.07752380
41Endometrial cancer_Homo sapiens_hsa052131.06251082
42Epstein-Barr virus infection_Homo sapiens_hsa051691.05989958
43Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.05188692
44Steroid biosynthesis_Homo sapiens_hsa001001.04435655
45Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.03542123
46Viral carcinogenesis_Homo sapiens_hsa052031.03310104
47Cysteine and methionine metabolism_Homo sapiens_hsa002701.02925865
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.02422449
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.97232853
50Renal cell carcinoma_Homo sapiens_hsa052110.90319587
51Purine metabolism_Homo sapiens_hsa002300.89619955
52HTLV-I infection_Homo sapiens_hsa051660.88607924
53FoxO signaling pathway_Homo sapiens_hsa040680.88493677
54Dorso-ventral axis formation_Homo sapiens_hsa043200.87960847
55mTOR signaling pathway_Homo sapiens_hsa041500.85367271
56Prostate cancer_Homo sapiens_hsa052150.82611260
57Legionellosis_Homo sapiens_hsa051340.81645254
58Tight junction_Homo sapiens_hsa045300.81053290
59Prolactin signaling pathway_Homo sapiens_hsa049170.79892793
60Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.78881932
61Chronic myeloid leukemia_Homo sapiens_hsa052200.78555814
62Hepatitis B_Homo sapiens_hsa051610.75550747
63* Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.74684406
64Thyroid hormone signaling pathway_Homo sapiens_hsa049190.74634624
65Bladder cancer_Homo sapiens_hsa052190.74516860
66Non-small cell lung cancer_Homo sapiens_hsa052230.72775446
67Selenocompound metabolism_Homo sapiens_hsa004500.70001705
68Biosynthesis of amino acids_Homo sapiens_hsa012300.69331858
69Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.69160675
70* Herpes simplex infection_Homo sapiens_hsa051680.69070842
71Propanoate metabolism_Homo sapiens_hsa006400.67352030
72Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.66258706
73Shigellosis_Homo sapiens_hsa051310.65293164
74VEGF signaling pathway_Homo sapiens_hsa043700.65123277
75Choline metabolism in cancer_Homo sapiens_hsa052310.65046876
76Basal cell carcinoma_Homo sapiens_hsa052170.63740035
77Toll-like receptor signaling pathway_Homo sapiens_hsa046200.63236761
78RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.63222761
79GnRH signaling pathway_Homo sapiens_hsa049120.62261095
80alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.61565070
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.60186203
82Ether lipid metabolism_Homo sapiens_hsa005650.58872114
83Linoleic acid metabolism_Homo sapiens_hsa005910.58814660
84Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.58313819
85Arginine and proline metabolism_Homo sapiens_hsa003300.57807274
86Hedgehog signaling pathway_Homo sapiens_hsa043400.56724509
87Proteoglycans in cancer_Homo sapiens_hsa052050.55962667
88* Circadian rhythm_Homo sapiens_hsa047100.55041342
89Pathways in cancer_Homo sapiens_hsa052000.54660733
90Prion diseases_Homo sapiens_hsa050200.54010803
91Salmonella infection_Homo sapiens_hsa051320.53405478
92Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53326305
93Pentose phosphate pathway_Homo sapiens_hsa000300.52760920
94Focal adhesion_Homo sapiens_hsa045100.51331301
95Viral myocarditis_Homo sapiens_hsa054160.51014989
96Proteasome_Homo sapiens_hsa030500.50100767
97Notch signaling pathway_Homo sapiens_hsa043300.48199882
98Longevity regulating pathway - mammal_Homo sapiens_hsa042110.47065860
99Central carbon metabolism in cancer_Homo sapiens_hsa052300.46963665
100AMPK signaling pathway_Homo sapiens_hsa041520.46465553
101Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.46457703
102Glioma_Homo sapiens_hsa052140.43420594
103* Wnt signaling pathway_Homo sapiens_hsa043100.42928184
104Apoptosis_Homo sapiens_hsa042100.42873614
105Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.40805578
106Folate biosynthesis_Homo sapiens_hsa007900.39914117
107Fatty acid metabolism_Homo sapiens_hsa012120.39706939
108Estrogen signaling pathway_Homo sapiens_hsa049150.39543119
109MAPK signaling pathway_Homo sapiens_hsa040100.38153258
110Insulin signaling pathway_Homo sapiens_hsa049100.37863534
111Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.37363141
112Melanoma_Homo sapiens_hsa052180.36626175
113Measles_Homo sapiens_hsa051620.35515259
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35124253
115Galactose metabolism_Homo sapiens_hsa000520.34325747
116ErbB signaling pathway_Homo sapiens_hsa040120.34276600
117Lysine degradation_Homo sapiens_hsa003100.33812967
118Acute myeloid leukemia_Homo sapiens_hsa052210.33238925
119N-Glycan biosynthesis_Homo sapiens_hsa005100.32563296
120Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.32156108
121Glucagon signaling pathway_Homo sapiens_hsa049220.32073365
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31973922
123ECM-receptor interaction_Homo sapiens_hsa045120.30757380
124Arginine biosynthesis_Homo sapiens_hsa002200.30021338
125Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.29289920
126HIF-1 signaling pathway_Homo sapiens_hsa040660.28923342
127Long-term depression_Homo sapiens_hsa047300.28097209
128Influenza A_Homo sapiens_hsa051640.27331065
129Systemic lupus erythematosus_Homo sapiens_hsa053220.26841418
130PI3K-Akt signaling pathway_Homo sapiens_hsa041510.26738469
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.22355413
132Fructose and mannose metabolism_Homo sapiens_hsa000510.22267978
133Ras signaling pathway_Homo sapiens_hsa040140.22256400
134Platelet activation_Homo sapiens_hsa046110.21630970
135Inositol phosphate metabolism_Homo sapiens_hsa005620.21135136
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20890525
137African trypanosomiasis_Homo sapiens_hsa051430.18218254
138Protein export_Homo sapiens_hsa030600.18013671

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