ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	imidazole-containing compound metabolic process (GO:0052803)	7.58796626
2	peptidyl-threonine dephosphorylation (GO:0035970)	6.46058406
3	replication fork processing (GO:0031297)	6.06660704
4	sequestering of actin monomers (GO:0042989)	5.68859979
5	behavioral response to nicotine (GO:0035095)	5.55888171
6	ribosomal small subunit assembly (GO:0000028)	4.95982581
7	positive regulation of catecholamine secretion (GO:0033605)	4.80259633
8	cellular biogenic amine biosynthetic process (GO:0042401)	4.65886904
9	positive regulation of meiosis (GO:0045836)	4.58411158
10	positive regulation of gastrulation (GO:2000543)	4.51804661
11	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	4.39818209
12	amine biosynthetic process (GO:0009309)	4.38757416
13	regulation of T cell tolerance induction (GO:0002664)	4.34210647
14	positive regulation of meiotic cell cycle (GO:0051446)	4.27357548
15	positive regulation of mast cell degranulation (GO:0043306)	4.16920917
16	positive regulation of mast cell activation involved in immune response (GO:0033008)	4.16920917
17	maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)	4.11020579
18	catecholamine biosynthetic process (GO:0042423)	4.04824998
19	catechol-containing compound biosynthetic process (GO:0009713)	4.04824998
20	nonmotile primary cilium assembly (GO:0035058)	3.92593366
21	negative regulation of mast cell activation (GO:0033004)	3.73611026
22	regulation of tolerance induction (GO:0002643)	3.67382014
23	cochlea development (GO:0090102)	3.65697785
24	regulation of T cell cytokine production (GO:0002724)	3.64317072
25	GTP biosynthetic process (GO:0006183)	3.62386772
26	positive regulation of mast cell activation (GO:0033005)	3.60516184
27	regulation of double-strand break repair via homologous recombination (GO:0010569)	3.60033397
28	centriole replication (GO:0007099)	3.57783211
29	DNA strand renaturation (GO:0000733)	3.50677893
30	protein K6-linked ubiquitination (GO:0085020)	3.45158403
31	indolalkylamine metabolic process (GO:0006586)	3.41251229
32	epithelial cilium movement (GO:0003351)	3.35666681
33	thrombin receptor signaling pathway (GO:0070493)	3.33962279
34	CENP-A containing nucleosome assembly (GO:0034080)	3.30167413
35	cellular ketone body metabolic process (GO:0046950)	3.26161410
36	positive regulation of embryonic development (GO:0040019)	3.26088242
37	chromatin remodeling at centromere (GO:0031055)	3.25434995
38	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.23787040
39	signal peptide processing (GO:0006465)	3.21578386
40	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.16736476
41	regulation of sensory perception of pain (GO:0051930)	3.16537733
42	regulation of sensory perception (GO:0051931)	3.16537733
43	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.13601474
44	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.13601474
45	NADH dehydrogenase complex assembly (GO:0010257)	3.13601474
46	UTP biosynthetic process (GO:0006228)	3.11551677
47	bile acid biosynthetic process (GO:0006699)	3.07270452
48	lateral sprouting from an epithelium (GO:0060601)	3.01591230
49	protein neddylation (GO:0045116)	3.01006448
50	synaptonemal complex assembly (GO:0007130)	2.99029604
51	tryptophan metabolic process (GO:0006568)	2.96835350
52	recombinational repair (GO:0000725)	2.96142769
53	kynurenine metabolic process (GO:0070189)	2.95172351
54	UTP metabolic process (GO:0046051)	2.95009503
55	indole-containing compound catabolic process (GO:0042436)	2.93790680
56	indolalkylamine catabolic process (GO:0046218)	2.93790680
57	tryptophan catabolic process (GO:0006569)	2.93790680
58	negative regulation of membrane potential (GO:0045837)	2.92232908
59	protein complex biogenesis (GO:0070271)	2.90608194
60	urate metabolic process (GO:0046415)	2.89020816
61	ketone body metabolic process (GO:1902224)	2.87186822
62	primary amino compound metabolic process (GO:1901160)	2.86887352
63	synaptonemal complex organization (GO:0070193)	2.85860594
64	nitric oxide mediated signal transduction (GO:0007263)	2.85144172
65	tachykinin receptor signaling pathway (GO:0007217)	2.84282194
66	DNA integration (GO:0015074)	2.81455384
67	cilium movement (GO:0003341)	2.77066169
68	platelet dense granule organization (GO:0060155)	2.75839624
69	multicellular organism reproduction (GO:0032504)	2.75646835
70	regulation of acrosome reaction (GO:0060046)	2.75130149
71	positive regulation of myeloid leukocyte mediated immunity (GO:0002888)	2.73219517
72	kidney morphogenesis (GO:0060993)	2.73091029
73	double-strand break repair via homologous recombination (GO:0000724)	2.72483257
74	indole-containing compound metabolic process (GO:0042430)	2.71519963
75	resolution of meiotic recombination intermediates (GO:0000712)	2.71486500
76	histone H3-K9 demethylation (GO:0033169)	2.70812658
77	male meiosis (GO:0007140)	2.70120987
78	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.69901576
79	T cell apoptotic process (GO:0070231)	2.68231881
80	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	2.67461732
81	serotonin metabolic process (GO:0042428)	2.66705135
82	endosome to melanosome transport (GO:0035646)	2.65803508
83	endosome to pigment granule transport (GO:0043485)	2.65803508
84	adaptation of signaling pathway (GO:0023058)	2.65538438
85	musculoskeletal movement (GO:0050881)	2.63730353
86	multicellular organismal movement (GO:0050879)	2.63730353
87	translesion synthesis (GO:0019985)	2.63710730
88	photoreceptor cell maintenance (GO:0045494)	2.62419906
89	angiotensin maturation (GO:0002003)	2.61256726
90	negative regulation of response to food (GO:0032096)	2.60501448
91	negative regulation of appetite (GO:0032099)	2.60501448
92	phenol-containing compound biosynthetic process (GO:0046189)	2.60327784
93	retinal cone cell development (GO:0046549)	2.59398038
94	negative regulation of neurological system process (GO:0031645)	2.58855771
95	regulation of cilium movement (GO:0003352)	2.58088654
96	histone exchange (GO:0043486)	2.55751982
97	thalamus development (GO:0021794)	2.53981569
98	reciprocal meiotic recombination (GO:0007131)	2.52672816
99	reciprocal DNA recombination (GO:0035825)	2.52672816
100	chromosome organization involved in meiosis (GO:0070192)	2.52319918

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	6.76511536
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.32730592
3	VDR_22108803_ChIP-Seq_LS180_Human	4.16117174
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	3.83572007
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.50976157
6	IGF1R_20145208_ChIP-Seq_DFB_Human	2.85745651
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.61560734
8	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.53293611
9	ZNF274_21170338_ChIP-Seq_K562_Hela	2.49117673
10	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.46994353
11	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	2.41334948
12	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.08960133
13	IRF1_19129219_ChIP-ChIP_H3396_Human	1.99681778
14	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.96716330
15	TP53_22573176_ChIP-Seq_HFKS_Human	1.93842664
16	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.93102508
17	TP63_19390658_ChIP-ChIP_HaCaT_Human	1.91584776
18	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.91357191
19	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.88039852
20	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.87578546
21	EWS_26573619_Chip-Seq_HEK293_Human	1.86020551
22	P300_19829295_ChIP-Seq_ESCs_Human	1.67938410
23	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.60937822
24	FUS_26573619_Chip-Seq_HEK293_Human	1.60364716
25	TAF15_26573619_Chip-Seq_HEK293_Human	1.59976758
26	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.58631115
27	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57802241
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.55542674
29	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53928220
30	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.52924857
31	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.52125083
32	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.50819982
33	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.49114397
34	BCAT_22108803_ChIP-Seq_LS180_Human	1.47700960
35	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.46053044
36	SMAD4_21799915_ChIP-Seq_A2780_Human	1.45874608
37	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.42293183
38	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.39915424
39	AR_25329375_ChIP-Seq_VCAP_Human	1.39021822
40	STAT3_23295773_ChIP-Seq_U87_Human	1.38712285
41	TCF4_22108803_ChIP-Seq_LS180_Human	1.34814371
42	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.33383154
43	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.33323467
44	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.30487978
45	SOX2_19829295_ChIP-Seq_ESCs_Human	1.29838168
46	NANOG_19829295_ChIP-Seq_ESCs_Human	1.29838168
47	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28166600
48	REST_21632747_ChIP-Seq_MESCs_Mouse	1.27253152
49	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.27107044
50	CBP_20019798_ChIP-Seq_JUKART_Human	1.27107044
51	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.24739847
52	TCF4_23295773_ChIP-Seq_U87_Human	1.23269690
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.23131046
54	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.22182756
55	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.21959255
56	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.21931363
57	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.21410521
58	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.21323751
59	AR_21572438_ChIP-Seq_LNCaP_Human	1.20220900
60	RNF2_27304074_Chip-Seq_NSC_Mouse	1.19746237
61	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.18867186
62	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.17728079
63	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	1.16443386
64	NCOR_22424771_ChIP-Seq_293T_Human	1.16280230
65	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.16014772
66	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	1.13831406
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.13492187
68	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.12523996
69	TAF2_19829295_ChIP-Seq_ESCs_Human	1.11851328
70	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.11664141
71	RUNX2_22187159_ChIP-Seq_PCA_Human	1.10872156
72	E2F1_18555785_Chip-Seq_ESCs_Mouse	1.10707124
73	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.09542905
74	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07913420
75	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.07913420
76	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07243512
77	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.06578630
78	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.06578630
79	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.05733264
80	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05223124
81	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.03884146
82	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.03775989
83	AR_20517297_ChIP-Seq_VCAP_Human	1.03600938
84	EGR1_23403033_ChIP-Seq_LIVER_Mouse	1.03066733
85	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.01980718
86	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.01656539
87	SMRT_27268052_Chip-Seq_Bcells_Human	1.01483946
88	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.00324944
89	P53_22387025_ChIP-Seq_ESCs_Mouse	0.99882225
90	EED_16625203_ChIP-ChIP_MESCs_Mouse	0.98043977
91	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	0.97928814
92	MYC_18940864_ChIP-ChIP_HL60_Human	0.97642641
93	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.97098098
94	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.97081181
95	STAT3_18555785_Chip-Seq_ESCs_Mouse	0.95171144
96	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.94848883
97	SMAD3_21741376_ChIP-Seq_EPCs_Human	0.93147002
98	GABP_17652178_ChIP-ChIP_JURKAT_Human	0.92860667
99	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.92502401
100	SUZ12_18555785_Chip-Seq_ESCs_Mouse	0.91977877

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	4.18157765
2	MP0002735_abnormal_chemical_nociception	3.72031122
3	MP0006292_abnormal_olfactory_placode	2.94837014
4	MP0003283_abnormal_digestive_organ	2.90907795
5	MP0005171_absent_coat_pigmentation	2.88869818
6	MP0003950_abnormal_plasma_membrane	2.56966439
7	MP0003693_abnormal_embryo_hatching	2.27890245
8	MP0008058_abnormal_DNA_repair	2.27078835
9	MP0003195_calcinosis	2.26027011
10	MP0002733_abnormal_thermal_nociception	2.12046433
11	MP0008877_abnormal_DNA_methylation	2.11318318
12	MP0001501_abnormal_sleep_pattern	2.06745785
13	MP0002638_abnormal_pupillary_reflex	2.03562970
14	MP0003718_maternal_effect	2.01635439
15	MP0001970_abnormal_pain_threshold	1.98028892
16	MP0001485_abnormal_pinna_reflex	1.96851819
17	MP0002736_abnormal_nociception_after	1.95965642
18	MP0002234_abnormal_pharynx_morphology	1.91258259
19	MP0005646_abnormal_pituitary_gland	1.90208312
20	MP0005410_abnormal_fertilization	1.89102751
21	MP0006276_abnormal_autonomic_nervous	1.88281179
22	MP0008789_abnormal_olfactory_epithelium	1.80768738
23	MP0000230_abnormal_systemic_arterial	1.78251014
24	MP0002734_abnormal_mechanical_nocicepti	1.70973024
25	MP0008995_early_reproductive_senescence	1.69378021
26	MP0005551_abnormal_eye_electrophysiolog	1.68930315
27	MP0008872_abnormal_physiological_respon	1.68208757
28	MP0009765_abnormal_xenobiotic_induced	1.65764154
29	MP0010094_abnormal_chromosome_stability	1.62774959
30	MP0006072_abnormal_retinal_apoptosis	1.60972974
31	MP0002971_abnormal_brown_adipose	1.60048841
32	MP0004142_abnormal_muscle_tone	1.56126538
33	MP0009745_abnormal_behavioral_response	1.53917599
34	MP0005085_abnormal_gallbladder_physiolo	1.53208880
35	MP0001984_abnormal_olfaction	1.50116732
36	MP0001873_stomach_inflammation	1.50002803
37	MP0005448_abnormal_energy_balance	1.48651212
38	MP0010386_abnormal_urinary_bladder	1.44460267
39	MP0003787_abnormal_imprinting	1.40613884
40	MP0003786_premature_aging	1.40453432
41	MP0008961_abnormal_basal_metabolism	1.39898258
42	MP0005253_abnormal_eye_physiology	1.39063932
43	MP0002572_abnormal_emotion/affect_behav	1.33167131
44	MP0002272_abnormal_nervous_system	1.32595929
45	MP0000372_irregular_coat_pigmentation	1.29463948
46	MP0009046_muscle_twitch	1.28405824
47	MP0005075_abnormal_melanosome_morpholog	1.27540005
48	MP0009379_abnormal_foot_pigmentation	1.27454969
49	MP0002160_abnormal_reproductive_system	1.24311317
50	MP0001968_abnormal_touch/_nociception	1.23149792
51	MP0005389_reproductive_system_phenotype	1.21796423
52	MP0009697_abnormal_copulation	1.21365231
53	MP0008775_abnormal_heart_ventricle	1.21341445
54	MP0002909_abnormal_adrenal_gland	1.20480833
55	MP0000631_abnormal_neuroendocrine_gland	1.19283191
56	MP0005334_abnormal_fat_pad	1.18293220
57	MP0002102_abnormal_ear_morphology	1.18237318
58	MP0000537_abnormal_urethra_morphology	1.15267336
59	MP0004145_abnormal_muscle_electrophysio	1.14288991
60	MP0005499_abnormal_olfactory_system	1.14131611
61	MP0005394_taste/olfaction_phenotype	1.14131611
62	MP0001929_abnormal_gametogenesis	1.13650068
63	MP0009053_abnormal_anal_canal	1.13350809
64	MP0000465_gastrointestinal_hemorrhage	1.12409690
65	MP0002148_abnormal_hypersensitivity_rea	1.09915648
66	MP0003638_abnormal_response/metabolism_	1.08399244
67	MP0002970_abnormal_white_adipose	1.07329790
68	MP0003698_abnormal_male_reproductive	1.06628817
69	MP0002557_abnormal_social/conspecific_i	1.06477707
70	MP0001881_abnormal_mammary_gland	1.05735999
71	MP0004742_abnormal_vestibular_system	1.05317807
72	MP0005310_abnormal_salivary_gland	1.01296186
73	MP0001119_abnormal_female_reproductive	0.99355535
74	MP0003119_abnormal_digestive_system	0.95415142
75	MP0002751_abnormal_autonomic_nervous	0.95218907
76	MP0005084_abnormal_gallbladder_morpholo	0.94146781
77	MP0004043_abnormal_pH_regulation	0.93312920
78	MP0003699_abnormal_female_reproductive	0.92692710
79	MP0002837_dystrophic_cardiac_calcinosis	0.91207770
80	MP0004885_abnormal_endolymph	0.91155989
81	MP0002938_white_spotting	0.91147955
82	MP0002210_abnormal_sex_determination	0.88010360
83	MP0002064_seizures	0.87620519
84	MP0008569_lethality_at_weaning	0.87104678
85	MP0008875_abnormal_xenobiotic_pharmacok	0.86124938
86	MP0000653_abnormal_sex_gland	0.83140797
87	MP0001905_abnormal_dopamine_level	0.81947645
88	MP0003936_abnormal_reproductive_system	0.80919679
89	MP0003183_abnormal_peptide_metabolism	0.79748610
90	MP0002184_abnormal_innervation	0.79431745
91	MP0001919_abnormal_reproductive_system	0.78073143
92	MP0005395_other_phenotype	0.78072792
93	MP0003938_abnormal_ear_development	0.76228494
94	MP0000049_abnormal_middle_ear	0.75732634
95	MP0004085_abnormal_heartbeat	0.75160522
96	MP0004215_abnormal_myocardial_fiber	0.74999870
97	MP0003937_abnormal_limbs/digits/tail_de	0.73138815
98	MP0002063_abnormal_learning/memory/cond	0.72846088
99	MP0000026_abnormal_inner_ear	0.72604718
100	MP0005083_abnormal_biliary_tract	0.69407805

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic fibrosis (HP:0100732)	3.81454333
2	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	3.61213300
3	Abnormality of alanine metabolism (HP:0010916)	3.61213300
4	Hyperalaninemia (HP:0003348)	3.61213300
5	Pancreatic cysts (HP:0001737)	3.60299182
6	Hypochromic microcytic anemia (HP:0004840)	3.41739231
7	Medial flaring of the eyebrow (HP:0010747)	3.39507967
8	True hermaphroditism (HP:0010459)	3.38644573
9	Duplicated collecting system (HP:0000081)	3.37661999
10	Abnormality of midbrain morphology (HP:0002418)	3.22825309
11	Molar tooth sign on MRI (HP:0002419)	3.22825309
12	Reticulocytopenia (HP:0001896)	3.20619497
13	Abnormality of the renal collecting system (HP:0004742)	3.17994856
14	Acute necrotizing encephalopathy (HP:0006965)	3.03510958
15	Rectovaginal fistula (HP:0000143)	3.00928263
16	Rectal fistula (HP:0100590)	3.00928263
17	Congenital, generalized hypertrichosis (HP:0004540)	2.99511017
18	Focal motor seizures (HP:0011153)	2.98853673
19	Increased CSF lactate (HP:0002490)	2.88619019
20	Absent thumb (HP:0009777)	2.83886152
21	Oligodactyly (hands) (HP:0001180)	2.82158492
22	Hepatocellular necrosis (HP:0001404)	2.71836688
23	Postaxial foot polydactyly (HP:0001830)	2.69012172
24	Agitation (HP:0000713)	2.68617268
25	Mitochondrial inheritance (HP:0001427)	2.66331329
26	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.65800066
27	Abnormal biliary tract physiology (HP:0012439)	2.52623283
28	Bile duct proliferation (HP:0001408)	2.52623283
29	Abnormal mitochondria in muscle tissue (HP:0008316)	2.51757613
30	Congenital sensorineural hearing impairment (HP:0008527)	2.50354929
31	Progressive macrocephaly (HP:0004481)	2.49859619
32	Gait imbalance (HP:0002141)	2.48570382
33	Abnormal ciliary motility (HP:0012262)	2.48284100
34	Renal Fanconi syndrome (HP:0001994)	2.47746633
35	Recurrent corneal erosions (HP:0000495)	2.44701243
36	Sclerocornea (HP:0000647)	2.44567310
37	Rhinitis (HP:0012384)	2.44501815
38	Cystic liver disease (HP:0006706)	2.44335456
39	Abnormality of the renal cortex (HP:0011035)	2.44002303
40	Hepatic necrosis (HP:0002605)	2.39651847
41	Congenital primary aphakia (HP:0007707)	2.38214384
42	Intestinal fistula (HP:0100819)	2.37734002
43	Acute encephalopathy (HP:0006846)	2.36820443
44	Large for gestational age (HP:0001520)	2.36675943
45	Congenital stationary night blindness (HP:0007642)	2.35161536
46	Male infertility (HP:0003251)	2.33468152
47	Abnormality of the renal medulla (HP:0100957)	2.33464111
48	Abnormal drinking behavior (HP:0030082)	2.32348478
49	Polydipsia (HP:0001959)	2.32348478
50	Synostosis of carpal bones (HP:0005048)	2.31339943
51	Vaginal fistula (HP:0004320)	2.30345806
52	Chorioretinal atrophy (HP:0000533)	2.29997985
53	Nephrogenic diabetes insipidus (HP:0009806)	2.29191401
54	Absent/shortened dynein arms (HP:0200106)	2.24149159
55	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.24149159
56	Nephronophthisis (HP:0000090)	2.23111976
57	Abnormality of DNA repair (HP:0003254)	2.22921776
58	Impulsivity (HP:0100710)	2.21737279
59	Failure to thrive in infancy (HP:0001531)	2.19325105
60	Anencephaly (HP:0002323)	2.19251821
61	Abnormal respiratory epithelium morphology (HP:0012253)	2.16286102
62	Abnormal respiratory motile cilium morphology (HP:0005938)	2.16286102
63	Abolished electroretinogram (ERG) (HP:0000550)	2.13817197
64	Increased hepatocellular lipid droplets (HP:0006565)	2.12726268
65	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.10463821
66	Chromsome breakage (HP:0040012)	2.02637159
67	Tubular atrophy (HP:0000092)	2.01456458
68	Ectopic kidney (HP:0000086)	1.98815082
69	Lipid accumulation in hepatocytes (HP:0006561)	1.96970429
70	Abnormal respiratory motile cilium physiology (HP:0012261)	1.94243176
71	Cerebral edema (HP:0002181)	1.94041968
72	Oligodactyly (HP:0012165)	1.92639212
73	Abnormality of the fibula (HP:0002991)	1.89952120
74	Tarsal synostosis (HP:0008368)	1.87074487
75	Chronic hepatic failure (HP:0100626)	1.86865710
76	Genital tract atresia (HP:0001827)	1.82803493
77	Abnormality of renal resorption (HP:0011038)	1.82470964
78	Polyuria (HP:0000103)	1.82467290
79	CNS demyelination (HP:0007305)	1.81848436
80	IgG deficiency (HP:0004315)	1.81188251
81	Congenital hepatic fibrosis (HP:0002612)	1.80124976
82	Holoprosencephaly (HP:0001360)	1.78858132
83	Poor coordination (HP:0002370)	1.76866775
84	Vaginal atresia (HP:0000148)	1.76517856
85	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.76471705
86	Furrowed tongue (HP:0000221)	1.75636203
87	Focal seizures (HP:0007359)	1.75189016
88	Absent radius (HP:0003974)	1.74699606
89	Hypochromic anemia (HP:0001931)	1.73489876
90	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	1.73463915
91	Stenosis of the external auditory canal (HP:0000402)	1.72071018
92	Abnormality of chromosome stability (HP:0003220)	1.72021970
93	Attenuation of retinal blood vessels (HP:0007843)	1.71398652
94	Abnormality of the ileum (HP:0001549)	1.68110482
95	Broad foot (HP:0001769)	1.67523295
96	Synostosis involving bones of the feet (HP:0009140)	1.66336476
97	Synostosis involving bones of the lower limbs (HP:0009138)	1.66336476
98	Abnormality of lateral ventricle (HP:0030047)	1.66312036
99	Male pseudohermaphroditism (HP:0000037)	1.66119892
100	Aplasia involving forearm bones (HP:0009822)	1.65889568

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TRIM28	6.64242818
2	FRK	5.79595542
3	TAOK3	4.73302231
4	VRK2	3.61527380
5	ADRBK2	2.81921036
6	PDK2	2.62887579
7	STK39	2.43316961
8	WNK4	2.28917400
9	ZAK	2.22892931
10	BMPR1B	2.11291663
11	GRK1	1.99904741
12	TNIK	1.94330979
13	NUAK1	1.93107544
14	VRK1	1.90627255
15	NME1	1.77795523
16	INSRR	1.52751646
17	OXSR1	1.44176520
18	GRK5	1.43974724
19	ACVR1B	1.42695860
20	BCKDK	1.37106480
21	PKN1	1.26218465
22	EIF2AK2	1.22251388
23	GRK6	1.21750791
24	PLK4	1.20891712
25	ADRBK1	1.18338293
26	FER	1.09634753
27	WNK3	1.03555351
28	STK16	1.00404460
29	PLK2	0.96889749
30	TEC	0.95133508
31	IKBKB	0.93354527
32	CDK19	0.92582424
33	ERBB3	0.90811570
34	PLK3	0.87279331
35	DYRK2	0.84076830
36	MAPK13	0.81902470
37	TIE1	0.80035381
38	BUB1	0.78095954
39	PNCK	0.76580861
40	MAP4K2	0.76448222
41	PIK3CG	0.75003598
42	TTK	0.74948853
43	MKNK1	0.72064862
44	TLK1	0.71315259
45	MKNK2	0.68865191
46	MINK1	0.67982282
47	PRKCG	0.64647872
48	CHEK2	0.63858838
49	DYRK1B	0.62589908
50	EIF2AK3	0.61909370
51	RPS6KA5	0.61778114
52	CHUK	0.60223279
53	CCNB1	0.60039827
54	ATR	0.59873029
55	STK10	0.59704073
56	DAPK2	0.56982066
57	AURKA	0.56322667
58	PRKCQ	0.55650585
59	OBSCN	0.55201716
60	ERN1	0.52633229
61	PRKACA	0.52212715
62	CAMK1	0.51671557
63	ITK	0.50593060
64	EPHA4	0.50040248
65	BMPR2	0.49980027
66	AURKB	0.49810605
67	PRKCE	0.46588088
68	CAMK2A	0.46212689
69	MAPKAPK3	0.45683670
70	KDR	0.42730257
71	PLK1	0.41625569
72	WNK1	0.40769856
73	PRKCA	0.40488921
74	IRAK1	0.39956316
75	GRK7	0.39788780
76	TRPM7	0.38236182
77	MAP2K1	0.37844062
78	CSF1R	0.37124913
79	MATK	0.36221820
80	EPHB2	0.36112793
81	PIM1	0.34874053
82	CSNK2A1	0.34813052
83	TNK2	0.34283433
84	ATM	0.33883363
85	CSNK1D	0.33672821
86	PIK3CA	0.33648024
87	TGFBR1	0.33445815
88	PTK2B	0.33230141
89	SYK	0.32894389
90	PIM2	0.32877635
91	PINK1	0.31588310
92	BTK	0.31029194
93	MAP2K2	0.28776461
94	LATS2	0.28348293
95	CSNK1A1L	0.27659705
96	PRKACB	0.27633752
97	LATS1	0.27068577
98	CAMK4	0.26280313
99	IKBKE	0.26004646
100	CSNK1G2	0.25119622

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Histidine metabolism_Homo sapiens_hsa00340	3.50033064
2	Primary bile acid biosynthesis_Homo sapiens_hsa00120	3.37399278
3	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	3.25283286
4	Homologous recombination_Homo sapiens_hsa03440	2.97869513
5	Asthma_Homo sapiens_hsa05310	2.84521634
6	Oxidative phosphorylation_Homo sapiens_hsa00190	2.36408561
7	Parkinsons disease_Homo sapiens_hsa05012	2.10368053
8	Fanconi anemia pathway_Homo sapiens_hsa03460	1.92623075
9	Cardiac muscle contraction_Homo sapiens_hsa04260	1.87826340
10	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.81545967
11	Ribosome_Homo sapiens_hsa03010	1.79353954
12	Peroxisome_Homo sapiens_hsa04146	1.77648797
13	Butanoate metabolism_Homo sapiens_hsa00650	1.73654921
14	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.71354344
15	Tryptophan metabolism_Homo sapiens_hsa00380	1.69286055
16	Olfactory transduction_Homo sapiens_hsa04740	1.67488360
17	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.65137369
18	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.61942666
19	RNA polymerase_Homo sapiens_hsa03020	1.55442164
20	Huntingtons disease_Homo sapiens_hsa05016	1.54906338
21	Phototransduction_Homo sapiens_hsa04744	1.52983801
22	Chemical carcinogenesis_Homo sapiens_hsa05204	1.51876621
23	Linoleic acid metabolism_Homo sapiens_hsa00591	1.45414442
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.45171202
25	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.43005729
26	Caffeine metabolism_Homo sapiens_hsa00232	1.42880588
27	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.40994038
28	Renin-angiotensin system_Homo sapiens_hsa04614	1.40190190
29	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.34439921
30	Nitrogen metabolism_Homo sapiens_hsa00910	1.33402812
31	Retinol metabolism_Homo sapiens_hsa00830	1.28985813
32	ABC transporters_Homo sapiens_hsa02010	1.27314724
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.25912317
34	Alzheimers disease_Homo sapiens_hsa05010	1.25911088
35	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.25333039
36	Glycerolipid metabolism_Homo sapiens_hsa00561	1.23811700
37	Mismatch repair_Homo sapiens_hsa03430	1.22723677
38	Salivary secretion_Homo sapiens_hsa04970	1.09018499
39	Basal cell carcinoma_Homo sapiens_hsa05217	1.07809752
40	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.02763714
41	Purine metabolism_Homo sapiens_hsa00230	1.01848136
42	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.01455990
43	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.00783554
44	Pyrimidine metabolism_Homo sapiens_hsa00240	0.99187434
45	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.98080615
46	Nicotine addiction_Homo sapiens_hsa05033	0.97128693
47	Serotonergic synapse_Homo sapiens_hsa04726	0.97122675
48	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.96847004
49	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.96319960
50	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.96270131
51	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.92986161
52	Bile secretion_Homo sapiens_hsa04976	0.92436014
53	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.89280798
54	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.88555727
55	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.88427018
56	Proteasome_Homo sapiens_hsa03050	0.88368938
57	Morphine addiction_Homo sapiens_hsa05032	0.86838159
58	Circadian entrainment_Homo sapiens_hsa04713	0.85114995
59	One carbon pool by folate_Homo sapiens_hsa00670	0.84446626
60	Taste transduction_Homo sapiens_hsa04742	0.82257533
61	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.81792807
62	Pancreatic secretion_Homo sapiens_hsa04972	0.75084103
63	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.72362972
64	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.70208001
65	Insulin secretion_Homo sapiens_hsa04911	0.65751443
66	Arginine and proline metabolism_Homo sapiens_hsa00330	0.61178923
67	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.59589926
68	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.59394359
69	GABAergic synapse_Homo sapiens_hsa04727	0.59175408
70	Primary immunodeficiency_Homo sapiens_hsa05340	0.58993204
71	Metabolic pathways_Homo sapiens_hsa01100	0.58646415
72	Fat digestion and absorption_Homo sapiens_hsa04975	0.58401702
73	Nucleotide excision repair_Homo sapiens_hsa03420	0.58209097
74	Calcium signaling pathway_Homo sapiens_hsa04020	0.57785655
75	Folate biosynthesis_Homo sapiens_hsa00790	0.56615403
76	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.54687256
77	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.53578511
78	DNA replication_Homo sapiens_hsa03030	0.53236355
79	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.53048724
80	Protein export_Homo sapiens_hsa03060	0.52594908
81	Long-term depression_Homo sapiens_hsa04730	0.52532105
82	RNA degradation_Homo sapiens_hsa03018	0.51420498
83	Cholinergic synapse_Homo sapiens_hsa04725	0.48323263
84	Renin secretion_Homo sapiens_hsa04924	0.47861870
85	Oocyte meiosis_Homo sapiens_hsa04114	0.46697641
86	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.46566134
87	Propanoate metabolism_Homo sapiens_hsa00640	0.46236163
88	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45540158
89	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.43598926
90	Selenocompound metabolism_Homo sapiens_hsa00450	0.42882184
91	PPAR signaling pathway_Homo sapiens_hsa03320	0.42029816
92	Glutamatergic synapse_Homo sapiens_hsa04724	0.41585039
93	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.41584907
94	Fatty acid degradation_Homo sapiens_hsa00071	0.39173622
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.37567055
96	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.34505265
97	Basal transcription factors_Homo sapiens_hsa03022	0.34279397
98	Platelet activation_Homo sapiens_hsa04611	0.33999183
99	Non-homologous end-joining_Homo sapiens_hsa03450	0.33244606
100	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.32178134

CUL1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »