CUL2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nucleobase biosynthetic process (GO:0046112)4.91594821
2purine nucleobase biosynthetic process (GO:0009113)4.73910910
3pore complex assembly (GO:0046931)4.48744290
4folic acid-containing compound biosynthetic process (GO:0009396)4.46752261
5mitotic sister chromatid cohesion (GO:0007064)4.39225788
6regulation of translational termination (GO:0006449)4.27614938
7DNA unwinding involved in DNA replication (GO:0006268)4.26721226
8non-recombinational repair (GO:0000726)4.26720511
9double-strand break repair via nonhomologous end joining (GO:0006303)4.26720511
10peptidyl-arginine omega-N-methylation (GO:0035247)4.20836207
11histone arginine methylation (GO:0034969)4.14903453
12IMP biosynthetic process (GO:0006188)4.10097767
13ribosome assembly (GO:0042255)4.08453187
14nuclear pore organization (GO:0006999)4.07405276
15cullin deneddylation (GO:0010388)3.97115097
16formation of translation preinitiation complex (GO:0001731)3.95915731
17mitotic metaphase plate congression (GO:0007080)3.94635846
18chaperone-mediated protein complex assembly (GO:0051131)3.85244066
19peptidyl-arginine N-methylation (GO:0035246)3.83358903
20peptidyl-arginine methylation (GO:0018216)3.83358903
21negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.77378739
22protein localization to chromosome, centromeric region (GO:0071459)3.76698737
23somatic diversification of immune receptors via somatic mutation (GO:0002566)3.72999707
24somatic hypermutation of immunoglobulin genes (GO:0016446)3.72999707
25protein deneddylation (GO:0000338)3.68942016
26DNA ligation (GO:0006266)3.68673728
27regulation of centriole replication (GO:0046599)3.67156679
28establishment of viral latency (GO:0019043)3.65422358
29ribosome biogenesis (GO:0042254)3.64931111
30establishment of protein localization to mitochondrial membrane (GO:0090151)3.63944231
31mitotic nuclear envelope disassembly (GO:0007077)3.59712049
32sister chromatid segregation (GO:0000819)3.57614163
33DNA replication initiation (GO:0006270)3.57016105
34positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.55196272
35IMP metabolic process (GO:0046040)3.55192144
36nuclear pore complex assembly (GO:0051292)3.53632876
37anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.53206478
38negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.53036349
39nuclear envelope disassembly (GO:0051081)3.52243165
40membrane disassembly (GO:0030397)3.52243165
41folic acid metabolic process (GO:0046655)3.50563450
42proteasome assembly (GO:0043248)3.47613854
43regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.46827860
44DNA strand elongation involved in DNA replication (GO:0006271)3.45771725
45Golgi transport vesicle coating (GO:0048200)3.45398471
46COPI coating of Golgi vesicle (GO:0048205)3.45398471
47regulation of chromosome segregation (GO:0051983)3.42608871
48ribonucleoprotein complex disassembly (GO:0032988)3.39350089
49regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.38301121
50paraxial mesoderm development (GO:0048339)3.37534944
51regulation of retinoic acid receptor signaling pathway (GO:0048385)3.37432565
52tRNA aminoacylation for protein translation (GO:0006418)3.34267127
53positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.33892833
54protein localization to kinetochore (GO:0034501)3.33230051
55metaphase plate congression (GO:0051310)3.31110391
56amino acid activation (GO:0043038)3.30877709
57tRNA aminoacylation (GO:0043039)3.30877709
58regulation of helicase activity (GO:0051095)3.29123496
59DNA double-strand break processing (GO:0000729)3.28979963
60DNA replication-dependent nucleosome organization (GO:0034723)3.26345405
61DNA replication-dependent nucleosome assembly (GO:0006335)3.26345405
62regulation of sister chromatid segregation (GO:0033045)3.25515522
63regulation of mitotic sister chromatid separation (GO:0010965)3.25515522
64regulation of mitotic sister chromatid segregation (GO:0033047)3.25515522
65DNA replication checkpoint (GO:0000076)3.24562590
66regulation of cellular amino acid metabolic process (GO:0006521)3.21795469
67CENP-A containing nucleosome assembly (GO:0034080)3.21518662
68DNA strand elongation (GO:0022616)3.18475378
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.16168974
70negative regulation of ligase activity (GO:0051352)3.16168974
71glycine metabolic process (GO:0006544)3.14565494
72de novo protein folding (GO:0006458)3.10503624
73mitotic chromosome condensation (GO:0007076)3.08942536
74positive regulation of ligase activity (GO:0051351)3.08932704
75transcription from mitochondrial promoter (GO:0006390)3.08637424
76attachment of spindle microtubules to kinetochore (GO:0008608)3.05808284
77regulation of spindle organization (GO:0090224)3.04829673
78establishment of chromosome localization (GO:0051303)3.01970869
79maturation of 5.8S rRNA (GO:0000460)3.01326684
80signal transduction involved in DNA integrity checkpoint (GO:0072401)3.01041314
81signal transduction involved in DNA damage checkpoint (GO:0072422)3.01041314
82DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.00206772
83regulation of sister chromatid cohesion (GO:0007063)2.99238585
84regulation of gene silencing by RNA (GO:0060966)2.97380599
85regulation of posttranscriptional gene silencing (GO:0060147)2.97380599
86regulation of gene silencing by miRNA (GO:0060964)2.97380599
87signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.96759601
88intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.96759601
89histone mRNA metabolic process (GO:0008334)2.96572162
90regulation of ubiquitin-protein transferase activity (GO:0051438)2.95655388
91signal transduction involved in cell cycle checkpoint (GO:0072395)2.94622230
92spindle checkpoint (GO:0031577)2.93576913
93COPII vesicle coating (GO:0048208)2.93487010
94nuclear envelope organization (GO:0006998)2.93117203
95signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.92905010
96signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.92905010
97signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.92905010
98mitotic sister chromatid segregation (GO:0000070)2.92840094
99mitotic spindle checkpoint (GO:0071174)2.92643170
100positive regulation of chromosome segregation (GO:0051984)2.92530900
101regulation of centrosome cycle (GO:0046605)2.92317529
102negative regulation of chromosome segregation (GO:0051985)2.92285397
103mitotic spindle assembly checkpoint (GO:0007094)2.92209730
104deoxyribonucleotide biosynthetic process (GO:0009263)2.91853872
105* G1/S transition of mitotic cell cycle (GO:0000082)2.91404071
106* cell cycle G1/S phase transition (GO:0044843)2.91404071
107regulation of translational fidelity (GO:0006450)2.90323827
108negative regulation of mitotic sister chromatid separation (GO:2000816)2.90087939
109negative regulation of mitotic sister chromatid segregation (GO:0033048)2.90087939
110negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.90087939
111negative regulation of sister chromatid segregation (GO:0033046)2.90087939
112spliceosomal snRNP assembly (GO:0000387)2.89257591
113organelle disassembly (GO:1903008)2.88345138
114establishment of integrated proviral latency (GO:0075713)2.87272296
115chromatin remodeling at centromere (GO:0031055)2.87140189
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.86751728
117spindle assembly checkpoint (GO:0071173)2.85208745
118nucleobase-containing small molecule interconversion (GO:0015949)2.83098407
119tRNA methylation (GO:0030488)2.82691847
120protein K11-linked ubiquitination (GO:0070979)2.82682630
121mitochondrial RNA metabolic process (GO:0000959)2.81800777
122negative regulation of DNA recombination (GO:0045910)2.80990823
123tetrahydrofolate metabolic process (GO:0046653)2.80514573
124de novo posttranslational protein folding (GO:0051084)2.80232817
125negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.80037195
126ventricular cardiac muscle cell development (GO:0055015)2.79556140
127positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.78053662
128positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.78053662
129positive regulation of mitotic sister chromatid separation (GO:1901970)2.78053662
130tricarboxylic acid cycle (GO:0006099)2.77241895
131histone exchange (GO:0043486)2.77193475
132regulation of ligase activity (GO:0051340)2.76266479
133heterochromatin organization (GO:0070828)2.75834810
134single strand break repair (GO:0000012)2.74681140
135regulation of mitotic metaphase/anaphase transition (GO:0030071)2.73182097
136DNA geometric change (GO:0032392)2.72894601
137pteridine-containing compound biosynthetic process (GO:0042559)2.72056844
138regulation of mitotic spindle organization (GO:0060236)2.71324822
139chromosome condensation (GO:0030261)2.71100993
140response to X-ray (GO:0010165)2.71086644
141DNA duplex unwinding (GO:0032508)2.70889901
142regulation of cofactor metabolic process (GO:0051193)2.70782879
143regulation of coenzyme metabolic process (GO:0051196)2.70782879
144protein localization to chromosome (GO:0034502)2.69050803

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.81668118
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.54304725
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.64710309
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.34274634
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.25401822
6CREB1_15753290_ChIP-ChIP_HEK293T_Human3.11918447
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.05797264
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03127773
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.99349565
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.97465073
11JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.95991897
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.92516470
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.90337085
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.86065966
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.80678106
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.73337719
17* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.61934891
18RBPJ_22232070_ChIP-Seq_NCS_Mouse2.49014300
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45036131
20AR_21909140_ChIP-Seq_LNCAP_Human2.42838361
21HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.42459824
22THAP11_20581084_ChIP-Seq_MESCs_Mouse2.33697533
23XRN2_22483619_ChIP-Seq_HELA_Human2.31127557
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.28461523
25POU5F1_18555785_ChIP-Seq_MESCs_Mouse2.27675567
26MYCN_18555785_ChIP-Seq_MESCs_Mouse2.25477767
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.24226048
28PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.23281963
29POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.11611953
30ESR1_15608294_ChIP-ChIP_MCF-7_Human2.11539053
31DCP1A_22483619_ChIP-Seq_HELA_Human2.01795185
32MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00135349
33SALL1_21062744_ChIP-ChIP_HESCs_Human1.97684970
34ZFX_18555785_ChIP-Seq_MESCs_Mouse1.97114643
35VDR_23849224_ChIP-Seq_CD4+_Human1.96057920
36GABP_19822575_ChIP-Seq_HepG2_Human1.95053137
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.94507109
38NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.93371138
39NANOG_18555785_ChIP-Seq_MESCs_Mouse1.92613755
40SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.81618298
41STAT3_1855785_ChIP-Seq_MESCs_Mouse1.76738358
42ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.72126948
43HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.71883008
44E2F1_21310950_ChIP-Seq_MCF-7_Human1.70966020
45WT1_19549856_ChIP-ChIP_CCG9911_Human1.68970190
46MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.68667885
47* FOXP3_21729870_ChIP-Seq_TREG_Human1.68208661
48* TTF2_22483619_ChIP-Seq_HELA_Human1.64382437
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.63125826
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63023489
51NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.62492285
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.59420755
53ELK1_19687146_ChIP-ChIP_HELA_Human1.56755483
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.56745027
55KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45526865
56* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42750813
57ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.41397158
58SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.41355383
59EGR1_19374776_ChIP-ChIP_THP-1_Human1.40384168
60SOX17_20123909_ChIP-Seq_XEN_Mouse1.39142907
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39099493
62POU3F2_20337985_ChIP-ChIP_501MEL_Human1.38677317
63PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.37965500
64CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36105243
65KDM5A_27292631_Chip-Seq_BREAST_Human1.35945092
66* TCF3_18692474_ChIP-Seq_MEFs_Mouse1.34655271
67NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.29897297
68SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26573653
69ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.25909458
70SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.24451129
71ZNF263_19887448_ChIP-Seq_K562_Human1.22657109
72ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.21824733
73CIITA_25753668_ChIP-Seq_RAJI_Human1.21813514
74CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.19310115
75SMAD_19615063_ChIP-ChIP_OVARY_Human1.18920157
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.18714330
77TFEB_21752829_ChIP-Seq_HELA_Human1.18431938
78TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17970757
79SRF_21415370_ChIP-Seq_HL-1_Mouse1.16010432
80CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.14258242
81SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.13382480
82FUS_26573619_Chip-Seq_HEK293_Human1.12739385
83NANOG_16153702_ChIP-ChIP_HESCs_Human1.11153881
84RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.10827678
85SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.10475968
86PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10280954
87OCT4_18692474_ChIP-Seq_MEFs_Mouse1.09458212
88ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09447974
89SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.09292739
90IGF1R_20145208_ChIP-Seq_DFB_Human1.08809819
91* BRD4_25478319_ChIP-Seq_HGPS_Human1.08744974
92SOX2_18692474_ChIP-Seq_MEFs_Mouse1.07404773
93NANOG_21062744_ChIP-ChIP_HESCs_Human1.07383473
94SALL4_18804426_ChIP-ChIP_XEN_Mouse1.07351721
95KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06851878
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06219351
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05461700
98KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05461700
99KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05461700
100E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04679228
101TAF15_26573619_Chip-Seq_HEK293_Human1.03991959
102* ELK1_22589737_ChIP-Seq_MCF10A_Human1.02418005
103NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.02220048
104GATA4_21415370_ChIP-Seq_HL-1_Mouse0.99454677
105* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99194879
106* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.98923107
107* TCF3_18692474_ChIP-Seq_MESCs_Mouse0.98229072
108* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97041098
109* ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.96219773
110* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94852795
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.94706916
112EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.93885049
113* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.93520062
114FLI1_27457419_Chip-Seq_LIVER_Mouse0.93113685
115SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.92950949
116ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92942781
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.92579346
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.92379430
119MYC_18940864_ChIP-ChIP_HL60_Human0.92041548
120ELF1_17652178_ChIP-ChIP_JURKAT_Human0.91166111
121DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.89683562
122FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.89611427
123EWS_26573619_Chip-Seq_HEK293_Human0.89565038
124CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89259506
125CLOCK_20551151_ChIP-Seq_293T_Human0.89230480
126* CHD1_26751641_Chip-Seq_LNCaP_Human0.87393562
127NOTCH1_21737748_ChIP-Seq_TLL_Human0.86462054
128HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81475614
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.80428127
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.79892213

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004957_abnormal_blastocyst_morpholog4.37843814
2MP0003123_paternal_imprinting4.31089907
3MP0003693_abnormal_embryo_hatching3.94488178
4MP0003806_abnormal_nucleotide_metabolis3.84173731
5MP0010094_abnormal_chromosome_stability3.78915576
6MP0003111_abnormal_nucleus_morphology3.53399725
7MP0008057_abnormal_DNA_replication3.40861114
8MP0003077_abnormal_cell_cycle2.91859476
9MP0002877_abnormal_melanocyte_morpholog2.72578457
10MP0001730_embryonic_growth_arrest2.54345885
11MP0006054_spinal_hemorrhage2.51095957
12MP0008932_abnormal_embryonic_tissue2.47260853
13MP0000749_muscle_degeneration2.46455619
14MP0008058_abnormal_DNA_repair2.36929339
15MP0000751_myopathy2.24275431
16MP0008877_abnormal_DNA_methylation2.18610437
17MP0003950_abnormal_plasma_membrane2.00345992
18MP0003941_abnormal_skin_development1.96397978
19MP0002837_dystrophic_cardiac_calcinosis1.95989869
20MP0005451_abnormal_body_composition1.95958186
21MP0005623_abnormal_meninges_morphology1.89644071
22MP0006035_abnormal_mitochondrial_morpho1.88755134
23MP0003121_genomic_imprinting1.86368743
24MP0000537_abnormal_urethra_morphology1.83782828
25MP0004233_abnormal_muscle_weight1.81086088
26MP0000350_abnormal_cell_proliferation1.78362826
27MP0010352_gastrointestinal_tract_polyps1.78280687
28MP0003890_abnormal_embryonic-extraembry1.75465608
29MP0001697_abnormal_embryo_size1.74850772
30MP0002269_muscular_atrophy1.70812452
31MP0010307_abnormal_tumor_latency1.68771202
32MP0002735_abnormal_chemical_nociception1.66940607
33MP0003718_maternal_effect1.66629592
34MP0003221_abnormal_cardiomyocyte_apopto1.62132239
35MP0004859_abnormal_synaptic_plasticity1.58973580
36MP0008007_abnormal_cellular_replicative1.57410939
37MP0005085_abnormal_gallbladder_physiolo1.55277598
38MP0002080_prenatal_lethality1.54530984
39MP0001672_abnormal_embryogenesis/_devel1.53536494
40MP0005380_embryogenesis_phenotype1.53536494
41MP0002139_abnormal_hepatobiliary_system1.46683762
42MP0002084_abnormal_developmental_patter1.45289297
43MP0003880_abnormal_central_pattern1.42640857
44MP0006036_abnormal_mitochondrial_physio1.41698100
45MP0000358_abnormal_cell_content/1.41502171
46MP0002085_abnormal_embryonic_tissue1.39802953
47MP0003984_embryonic_growth_retardation1.38864142
48MP0004272_abnormal_basement_membrane1.38224581
49MP0001968_abnormal_touch/_nociception1.38118863
50MP0005266_abnormal_metabolism1.37200793
51MP0002088_abnormal_embryonic_growth/wei1.37193170
52MP0003566_abnormal_cell_adhesion1.36398397
53MP0004858_abnormal_nervous_system1.34906344
54MP0004197_abnormal_fetal_growth/weight/1.33850347
55MP0003122_maternal_imprinting1.32235636
56MP0004133_heterotaxia1.29739017
57MP0004270_analgesia1.29597437
58MP0009672_abnormal_birth_weight1.27396046
59MP0003119_abnormal_digestive_system1.25818115
60MP0009697_abnormal_copulation1.25245453
61MP0002086_abnormal_extraembryonic_tissu1.23075946
62MP0002736_abnormal_nociception_after1.22702548
63MP0003329_amyloid_beta_deposits1.19427706
64MP0000747_muscle_weakness1.18643795
65MP0004036_abnormal_muscle_relaxation1.16192091
66MP0005360_urolithiasis1.15513136
67MP0003786_premature_aging1.14485163
68MP0003705_abnormal_hypodermis_morpholog1.12323651
69MP0004084_abnormal_cardiac_muscle1.10878891
70MP0005365_abnormal_bile_salt1.07219166
71MP0006276_abnormal_autonomic_nervous1.06940538
72MP0001727_abnormal_embryo_implantation1.05332612
73MP0000647_abnormal_sebaceous_gland1.04873337
74MP0010234_abnormal_vibrissa_follicle1.04499131
75MP0003385_abnormal_body_wall1.04449251
76MP0008260_abnormal_autophagy1.03433402
77MP0000759_abnormal_skeletal_muscle1.02362391
78MP0005083_abnormal_biliary_tract1.01572378
79MP0001915_intracranial_hemorrhage0.99778149
80MP0001299_abnormal_eye_distance/0.98742888
81MP0003635_abnormal_synaptic_transmissio0.98717274
82MP0004087_abnormal_muscle_fiber0.96738719
83MP0004215_abnormal_myocardial_fiber0.96024320
84MP0003567_abnormal_fetal_cardiomyocyte0.94917148
85MP0002009_preneoplasia0.94609564
86MP0002127_abnormal_cardiovascular_syste0.94263134
87MP0001529_abnormal_vocalization0.94186260
88MP0001145_abnormal_male_reproductive0.93858667
89MP0002063_abnormal_learning/memory/cond0.92595035
90MP0003937_abnormal_limbs/digits/tail_de0.92142913
91MP0003186_abnormal_redox_activity0.92002022
92MP0003191_abnormal_cellular_cholesterol0.91755478
93MP0001243_abnormal_dermal_layer0.90141449
94MP0000733_abnormal_muscle_development0.89585869
95MP0001661_extended_life_span0.89384610
96MP0005332_abnormal_amino_acid0.89177628
97MP0004811_abnormal_neuron_physiology0.87880733
98MP0005384_cellular_phenotype0.87551419
99MP0002734_abnormal_mechanical_nocicepti0.87081268
100MP0002210_abnormal_sex_determination0.86084059
101MP0004145_abnormal_muscle_electrophysio0.84078151
102MP0002060_abnormal_skin_morphology0.84040570
103MP0002160_abnormal_reproductive_system0.82955724
104MP0000604_amyloidosis0.82756586
105MP0002254_reproductive_system_inflammat0.82318748
106MP0002733_abnormal_thermal_nociception0.82069339
107MP0008438_abnormal_cutaneous_collagen0.81626132
108MP0002177_abnormal_outer_ear0.81524261
109MP0002184_abnormal_innervation0.80721527
110MP0000313_abnormal_cell_death0.80436730
111MP0002106_abnormal_muscle_physiology0.80377233
112MP0005248_abnormal_Harderian_gland0.79603884
113MP0002972_abnormal_cardiac_muscle0.78225918
114MP0003646_muscle_fatigue0.77438057
115MP0005501_abnormal_skin_physiology0.76914823
116MP0009703_decreased_birth_body0.76410583
117MP0010678_abnormal_skin_adnexa0.74498562
118MP0003861_abnormal_nervous_system0.74390215
119MP0001348_abnormal_lacrimal_gland0.73992220
120MP0000653_abnormal_sex_gland0.73118019
121MP0002163_abnormal_gland_morphology0.72510755
122MP0001191_abnormal_skin_condition0.70595971
123MP0002102_abnormal_ear_morphology0.70498798
124MP0000372_irregular_coat_pigmentation0.70342510
125MP0005319_abnormal_enzyme/_coenzyme0.69804821
126MP0005620_abnormal_muscle_contractility0.69537597
127MP0002796_impaired_skin_barrier0.68350260
128MP0008775_abnormal_heart_ventricle0.68143235
129MP0002233_abnormal_nose_morphology0.68037771
130MP0001929_abnormal_gametogenesis0.67654946
131MP0001440_abnormal_grooming_behavior0.66680664
132MP0000013_abnormal_adipose_tissue0.66184298
133MP0005621_abnormal_cell_physiology0.66158166
134MP0005379_endocrine/exocrine_gland_phen0.65653430
135MP0001293_anophthalmia0.65534025
136MP0005410_abnormal_fertilization0.65347827
137MP0005187_abnormal_penis_morphology0.65073139
138MP0002332_abnormal_exercise_endurance0.64693263
139MP0005330_cardiomyopathy0.64527818
140MP0000750_abnormal_muscle_regeneration0.64120205
141MP0003935_abnormal_craniofacial_develop0.64056565
142MP0005386_behavior/neurological_phenoty0.64039060
143MP0004924_abnormal_behavior0.64039060
144MP0002751_abnormal_autonomic_nervous0.63364532
145MP0002019_abnormal_tumor_incidence0.62159765
146MP0010030_abnormal_orbit_morphology0.61685859

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)4.49298590
2Exercise-induced muscle cramps (HP:0003710)4.30137775
3Abnormality of the labia minora (HP:0012880)4.23899358
4Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.15972051
5Muscle fiber inclusion bodies (HP:0100299)4.13425744
6Birth length less than 3rd percentile (HP:0003561)4.12027231
7Ependymoma (HP:0002888)4.12023823
8Abnormality of glycolysis (HP:0004366)3.99276976
9Increased serum pyruvate (HP:0003542)3.99276976
10Colon cancer (HP:0003003)3.35119865
11Cerebral hypomyelination (HP:0006808)3.32486363
12Shoulder girdle muscle weakness (HP:0003547)3.30734532
13Termporal pattern (HP:0011008)3.16821942
14Insidious onset (HP:0003587)3.16821942
15Agnosia (HP:0010524)3.13752316
16Breast hypoplasia (HP:0003187)3.06546109
17Hypobetalipoproteinemia (HP:0003563)3.05410713
18Astrocytoma (HP:0009592)2.93808449
19Abnormality of the astrocytes (HP:0100707)2.93808449
20Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.84004049
21Degeneration of anterior horn cells (HP:0002398)2.80710916
22Abnormality of the anterior horn cell (HP:0006802)2.80710916
23Atrophy/Degeneration involving motor neurons (HP:0007373)2.79522673
24Angiofibromas (HP:0010615)2.71010812
25Adenoma sebaceum (HP:0009720)2.71010812
26Hyperglycinemia (HP:0002154)2.70754075
27Carpal bone hypoplasia (HP:0001498)2.70738511
28Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.70696573
29Abnormality of alanine metabolism (HP:0010916)2.70696573
30Hyperalaninemia (HP:0003348)2.70696573
31Rhabdomyosarcoma (HP:0002859)2.70410451
32Progressive external ophthalmoplegia (HP:0000590)2.68568279
33Pelvic girdle muscle weakness (HP:0003749)2.68110499
34Abnormality of the lower motor neuron (HP:0002366)2.67688251
35Biliary tract neoplasm (HP:0100574)2.67501039
36Medulloblastoma (HP:0002885)2.61984452
37Abnormal umbilical cord blood vessels (HP:0011403)2.59531641
38Single umbilical artery (HP:0001195)2.59531641
39Abnormality of the fetal cardiovascular system (HP:0010948)2.59531641
40Amyotrophic lateral sclerosis (HP:0007354)2.53880338
41Microglossia (HP:0000171)2.53536091
42Abnormality of the musculature of the pelvis (HP:0001469)2.53286408
43Abnormality of the hip-girdle musculature (HP:0001445)2.53286408
44Chromosomal breakage induced by crosslinking agents (HP:0003221)2.49482307
45Oral leukoplakia (HP:0002745)2.49125866
46Volvulus (HP:0002580)2.49003250
47Multiple enchondromatosis (HP:0005701)2.47612250
48Glioma (HP:0009733)2.45944374
49Abnormality of the umbilical cord (HP:0010881)2.41432611
50Delusions (HP:0000746)2.34327970
51Tetraparesis (HP:0002273)2.34168441
52Abnormal gallbladder physiology (HP:0012438)2.33089744
53Cholecystitis (HP:0001082)2.33089744
54Abnormality of methionine metabolism (HP:0010901)2.32063861
55Limb-girdle muscle atrophy (HP:0003797)2.30621397
56Proximal placement of thumb (HP:0009623)2.30281714
57Type 1 muscle fiber predominance (HP:0003803)2.29258707
58Abnormalities of placenta or umbilical cord (HP:0001194)2.28811163
59Deviation of the thumb (HP:0009603)2.28782338
60Embryonal renal neoplasm (HP:0011794)2.28767799
61Chromsome breakage (HP:0040012)2.26485615
62Postnatal microcephaly (HP:0005484)2.25732024
63Poor suck (HP:0002033)2.24374617
64Abnormality of chromosome stability (HP:0003220)2.23853270
65Selective tooth agenesis (HP:0001592)2.23828866
66CNS hypomyelination (HP:0003429)2.21836443
67Nephroblastoma (Wilms tumor) (HP:0002667)2.21774310
68Increased serum lactate (HP:0002151)2.19147624
69Subaortic stenosis (HP:0001682)2.17853781
70Abnormality of the left ventricular outflow tract (HP:0011103)2.17853781
71Exercise-induced myalgia (HP:0003738)2.16103228
72Myoglobinuria (HP:0002913)2.15440394
73Delayed gross motor development (HP:0002194)2.14137997
74Cortical dysplasia (HP:0002539)2.13960607
75Pheochromocytoma (HP:0002666)2.12855957
76Abnormality of serum amino acid levels (HP:0003112)2.12356285
77Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.11631564
78Unilateral renal agenesis (HP:0000122)2.11415574
79Neck muscle weakness (HP:0000467)2.10709519
80Upper limb muscle weakness (HP:0003484)2.09211933
81Abnormal auditory evoked potentials (HP:0006958)2.08115566
82Neoplasm of the rectum (HP:0100743)2.08095421
83Palpitations (HP:0001962)2.08060866
84Abnormality of pyrimidine metabolism (HP:0004353)2.07963479
85Reduced antithrombin III activity (HP:0001976)2.07151392
86Progressive muscle weakness (HP:0003323)2.06401157
87Impulsivity (HP:0100710)2.05851561
88Dysautonomia (HP:0002459)2.04118139
89Neuroendocrine neoplasm (HP:0100634)2.03993805
90Abnormal neuron morphology (HP:0012757)2.02379579
91Abnormality of the motor neurons (HP:0002450)2.02379579
92Impaired pain sensation (HP:0007328)2.01782154
93Abnormality of pain sensation (HP:0010832)2.01782154
94Premature ovarian failure (HP:0008209)2.01316387
95EMG: myopathic abnormalities (HP:0003458)2.01267025
96Emotional lability (HP:0000712)2.00639323
97Unsteady gait (HP:0002317)1.99456050
98Rhabdomyolysis (HP:0003201)1.98259278
99Neoplasm of the small intestine (HP:0100833)1.98187654
100Limb-girdle muscle weakness (HP:0003325)1.97982446
101Abnormal biliary tract morphology (HP:0012440)1.97456430
102CNS demyelination (HP:0007305)1.97378356
103Abnormal lung lobation (HP:0002101)1.97025526
104Orthostatic hypotension (HP:0001278)1.96585228
105Visual hallucinations (HP:0002367)1.96386107
106Intestinal polyposis (HP:0200008)1.95276276
107Neoplasm of the pancreas (HP:0002894)1.94706850
108Rimmed vacuoles (HP:0003805)1.94564420
109Neoplasm of the peripheral nervous system (HP:0100007)1.94475317
110Increased CSF lactate (HP:0002490)1.93086564
111Aplastic anemia (HP:0001915)1.92002020
112Thyroid carcinoma (HP:0002890)1.90313276
113Centrally nucleated skeletal muscle fibers (HP:0003687)1.90223946
114Patellar aplasia (HP:0006443)1.90196800
115Neoplasm of the colon (HP:0100273)1.89580527
116Neuroblastic tumors (HP:0004376)1.89237502
117Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.89237502
118Neuroblastoma (HP:0003006)1.89237502
119Primitive neuroectodermal tumor (HP:0030065)1.89237502
120Reduced subcutaneous adipose tissue (HP:0003758)1.88941495
121Neoplasm of striated muscle (HP:0009728)1.87220491
122Megaloblastic anemia (HP:0001889)1.87098616
123Tetraplegia (HP:0002445)1.86298367
124Gout (HP:0001997)1.86202971
125Hypokinesia (HP:0002375)1.86083596
126Hyperglycinuria (HP:0003108)1.85927055
127Secondary amenorrhea (HP:0000869)1.85816023
128Cerebral edema (HP:0002181)1.85700379
129Athetosis (HP:0002305)1.85105063
130Resting tremor (HP:0002322)1.84100828
131Intestinal polyp (HP:0005266)1.83770914
132Spastic diplegia (HP:0001264)1.82939452
133Ovarian neoplasm (HP:0100615)1.82790943
134Pancreatic islet-cell hyperplasia (HP:0004510)1.81849577
135Urinary urgency (HP:0000012)1.81644989
136Personality changes (HP:0000751)1.80325072
137Delayed puberty (HP:0000823)1.79709284
138Papillary thyroid carcinoma (HP:0002895)1.79019978
139Hypolipoproteinemia (HP:0010981)1.78179271
140Areflexia of lower limbs (HP:0002522)1.77109600
141Absent radius (HP:0003974)1.76756412
142Premature rupture of membranes (HP:0001788)1.76131638
143Microvesicular hepatic steatosis (HP:0001414)1.75883700
144Increased connective tissue (HP:0009025)1.75854920
145Aplasia/Hypoplasia of the patella (HP:0006498)1.75650878
146Neoplasm of the adrenal gland (HP:0100631)1.75615294
147Abnormality of glycine metabolism (HP:0010895)1.75190870
148Abnormality of serine family amino acid metabolism (HP:0010894)1.75190870
149Abnormality of monocarboxylic acid metabolism (HP:0010996)1.75013659
150Aplasia/Hypoplasia of the sternum (HP:0006714)1.74985024
151Overlapping toe (HP:0001845)1.74961111
152Neoplasm of the oral cavity (HP:0100649)1.74705380
153Supernumerary spleens (HP:0009799)1.73295694
154Rough bone trabeculation (HP:0100670)1.73263083
155Ragged-red muscle fibers (HP:0003200)1.72297265
156Decreased activity of mitochondrial respiratory chain (HP:0008972)1.70641752
157Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.70641752
158Autoamputation (HP:0001218)1.68932651
159Increased nuchal translucency (HP:0010880)1.68868461
160Long clavicles (HP:0000890)1.68748821
161Calcaneovalgus deformity (HP:0001848)1.67811366
162Abnormality of the shoulder girdle musculature (HP:0001435)1.67317744
163Proximal amyotrophy (HP:0007126)1.65265910
164Horizontal nystagmus (HP:0000666)1.63763717
165Distal lower limb amyotrophy (HP:0008944)1.62803135
166Abnormality of placental membranes (HP:0011409)1.62675032
167Amniotic constriction ring (HP:0009775)1.62675032
168Abnormality of the preputium (HP:0100587)1.61173560
169Breast carcinoma (HP:0003002)1.60352770
170Narrow face (HP:0000275)1.59552817
171Entropion (HP:0000621)1.56985678
172Hypoalphalipoproteinemia (HP:0003233)1.56939398

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB13.92126613
2NEK13.75729091
3WEE13.60957571
4EIF2AK13.59066286
5TSSK63.22502521
6TRIM283.07223508
7CDC73.03430833
8LATS12.57853590
9ERBB32.48722406
10ACVR1B2.48036481
11SCYL22.39528465
12PNCK2.33710430
13AKT32.23189440
14PLK32.03766808
15PDK31.88886672
16PDK41.88886672
17MAP3K91.85563123
18MST41.85271537
19TTK1.83723843
20EIF2AK31.81886687
21LATS21.66202753
22PLK11.59670655
23PLK21.56301183
24MINK11.51736169
25PASK1.51662973
26MARK11.51206231
27BCR1.49499151
28KSR11.45785345
29MAP3K41.45578172
30SRPK11.41071168
31BRSK21.40932307
32CCNB11.37721032
33BRAF1.37407758
34KSR21.34511268
35NTRK31.34252709
36MST1R1.33102358
37NEK21.28715675
38ARAF1.26141011
39AURKA1.25348664
40TESK21.22892492
41NEK91.19170687
42DAPK11.18970390
43BRSK11.15062721
44LIMK11.14516456
45EPHA21.14194772
46TAF11.13699167
47MKNK21.12830007
48SIK31.11842040
49BCKDK1.11827988
50STK38L1.10198190
51TAOK21.10159706
52PLK41.08366160
53BRD41.07510040
54TTN1.06410212
55CSNK1A1L0.98415883
56RAF10.97499370
57CHEK10.96044002
58ATR0.94504286
59STK30.94116358
60CSNK1G10.92767487
61MAP3K80.90708219
62CHEK20.88648883
63NME10.87661019
64BMPR20.86703224
65TGFBR10.85565235
66DYRK20.85062393
67MAP2K40.83673522
68RPS6KB20.82505452
69CDK140.78212960
70PDK20.77684038
71IRAK30.77223005
72CDK60.77095727
73MAP3K100.76917826
74STK100.75486823
75AURKB0.75290998
76MET0.74670143
77CASK0.73959375
78PRKCG0.72071111
79MAPKAPK30.70521427
80CSNK1E0.70227725
81CSNK2A20.69996653
82PRKCI0.69304837
83ALK0.68809023
84ATM0.67486813
85CDK180.66926391
86CDK70.66780843
87CDK20.66052052
88TESK10.65424498
89PAK60.63182107
90EPHA40.61315495
91DYRK30.61286331
92CDK150.61136908
93MAP3K50.60639226
94RPS6KA40.60422731
95CDK40.58044984
96MKNK10.55120125
97CDK10.54376132
98OBSCN0.53941539
99CDK11A0.52917506
100CLK10.52491775
101MELK0.52073217
102PHKG20.50491798
103PHKG10.50491798
104NME20.50413540
105CSNK1G20.50291706
106CSNK2A10.49768541
107STK160.49702131
108MOS0.49449691
109PTK20.48171439
110RPS6KB10.48052677
111PKN20.46685771
112YES10.46610983
113MAP3K120.46388578
114STK240.45781596
115DAPK20.45239887
116FGFR10.44178459
117EIF2AK20.43979786
118PBK0.43790352
119CDK90.43475459
120STK380.43071176
121MAP3K110.42908635
122FER0.42792174
123WNK30.42379619
124CSNK1G30.41946548
125PAK40.41717045
126PDGFRA0.40352208
127PRKD30.39987816
128STK40.39139917
129CDK80.38472911
130MAP2K70.37231857
131ERBB40.36418737
132MAP4K20.35686466
133MAP2K10.35551367
134GRK50.35225038
135AKT20.33261613
136NEK60.30881187

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.36909729
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.62182236
3Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009703.29450856
4Mismatch repair_Homo sapiens_hsa034303.26758262
5DNA replication_Homo sapiens_hsa030303.21275202
6RNA transport_Homo sapiens_hsa030133.02825943
7Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.95874114
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.88542321
9Protein export_Homo sapiens_hsa030602.87084341
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.69155123
11One carbon pool by folate_Homo sapiens_hsa006702.60396667
12Spliceosome_Homo sapiens_hsa030402.40698503
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28745785
14RNA polymerase_Homo sapiens_hsa030202.18232936
15Cell cycle_Homo sapiens_hsa041102.03314435
16Biosynthesis of amino acids_Homo sapiens_hsa012301.93886459
17Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.91550979
18Nucleotide excision repair_Homo sapiens_hsa034201.86665691
19Carbon metabolism_Homo sapiens_hsa012001.85971938
20Steroid biosynthesis_Homo sapiens_hsa001001.76718699
21Oocyte meiosis_Homo sapiens_hsa041141.76459846
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.75266098
23Base excision repair_Homo sapiens_hsa034101.72445775
24Fatty acid elongation_Homo sapiens_hsa000621.68746012
25Pyrimidine metabolism_Homo sapiens_hsa002401.67482834
26Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53178899
27mRNA surveillance pathway_Homo sapiens_hsa030151.53054534
28Pyruvate metabolism_Homo sapiens_hsa006201.47017068
29Homologous recombination_Homo sapiens_hsa034401.45804658
30Selenocompound metabolism_Homo sapiens_hsa004501.39751521
31Vitamin B6 metabolism_Homo sapiens_hsa007501.33851164
32Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.22579203
33Adherens junction_Homo sapiens_hsa045201.18665716
34Folate biosynthesis_Homo sapiens_hsa007901.15379669
35Arginine biosynthesis_Homo sapiens_hsa002201.15034694
36* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.14742815
37Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.13140680
38Basal transcription factors_Homo sapiens_hsa030221.10917271
39RNA degradation_Homo sapiens_hsa030181.08377543
40Non-homologous end-joining_Homo sapiens_hsa034501.07486100
41Synaptic vesicle cycle_Homo sapiens_hsa047211.07405044
42Parkinsons disease_Homo sapiens_hsa050121.02703489
43Primary bile acid biosynthesis_Homo sapiens_hsa001201.00027174
44Propanoate metabolism_Homo sapiens_hsa006400.95846258
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95701529
46Shigellosis_Homo sapiens_hsa051310.95256898
47Drug metabolism - other enzymes_Homo sapiens_hsa009830.95100244
48Cyanoamino acid metabolism_Homo sapiens_hsa004600.94339757
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.93849183
50Oxidative phosphorylation_Homo sapiens_hsa001900.92816527
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91113212
52Nitrogen metabolism_Homo sapiens_hsa009100.89447317
53Circadian rhythm_Homo sapiens_hsa047100.89152378
54p53 signaling pathway_Homo sapiens_hsa041150.87213419
55Purine metabolism_Homo sapiens_hsa002300.87211817
56Epstein-Barr virus infection_Homo sapiens_hsa051690.86863208
57Huntingtons disease_Homo sapiens_hsa050160.85636982
58Butanoate metabolism_Homo sapiens_hsa006500.85634534
59Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.83996743
60Pentose phosphate pathway_Homo sapiens_hsa000300.82639823
61Fructose and mannose metabolism_Homo sapiens_hsa000510.78889197
62Fanconi anemia pathway_Homo sapiens_hsa034600.76347319
63Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75789707
64Regulation of autophagy_Homo sapiens_hsa041400.75694635
65N-Glycan biosynthesis_Homo sapiens_hsa005100.75467953
66Phenylalanine metabolism_Homo sapiens_hsa003600.75178772
67Long-term potentiation_Homo sapiens_hsa047200.73804510
68Thyroid cancer_Homo sapiens_hsa052160.71308414
69Sulfur relay system_Homo sapiens_hsa041220.69301608
70Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.66996869
71Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65374857
72TGF-beta signaling pathway_Homo sapiens_hsa043500.64215931
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.63168040
74Sulfur metabolism_Homo sapiens_hsa009200.56176557
75Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.54707749
76Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.54362617
77Tryptophan metabolism_Homo sapiens_hsa003800.54015809
78Ribosome_Homo sapiens_hsa030100.52336764
79Collecting duct acid secretion_Homo sapiens_hsa049660.51654575
80Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.50514720
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.50335448
82mTOR signaling pathway_Homo sapiens_hsa041500.50112342
83Central carbon metabolism in cancer_Homo sapiens_hsa052300.48399171
84Tight junction_Homo sapiens_hsa045300.44843828
85Cardiac muscle contraction_Homo sapiens_hsa042600.44541365
86Fatty acid degradation_Homo sapiens_hsa000710.44380104
87Legionellosis_Homo sapiens_hsa051340.42596037
88Sphingolipid metabolism_Homo sapiens_hsa006000.41455463
89Tyrosine metabolism_Homo sapiens_hsa003500.40962892
90Vibrio cholerae infection_Homo sapiens_hsa051100.40681632
91Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.40448763
92Salmonella infection_Homo sapiens_hsa051320.39598313
93Prion diseases_Homo sapiens_hsa050200.39487615
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.39344523
95Nicotine addiction_Homo sapiens_hsa050330.38836296
96Alzheimers disease_Homo sapiens_hsa050100.38693082
97Viral carcinogenesis_Homo sapiens_hsa052030.37516350
98Wnt signaling pathway_Homo sapiens_hsa043100.37343408
99Insulin signaling pathway_Homo sapiens_hsa049100.36897168
100Proteoglycans in cancer_Homo sapiens_hsa052050.36786610
101Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.35327937
102Glutathione metabolism_Homo sapiens_hsa004800.35229077
103Glucagon signaling pathway_Homo sapiens_hsa049220.34463027
104Metabolic pathways_Homo sapiens_hsa011000.33995502
105Arginine and proline metabolism_Homo sapiens_hsa003300.33772954
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32891436
107Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.30600703
108Small cell lung cancer_Homo sapiens_hsa052220.30534472
109Dopaminergic synapse_Homo sapiens_hsa047280.29355913
110MicroRNAs in cancer_Homo sapiens_hsa052060.28637292
111Hippo signaling pathway_Homo sapiens_hsa043900.28272326
112Fatty acid metabolism_Homo sapiens_hsa012120.24699381
113Focal adhesion_Homo sapiens_hsa045100.22775286
114Peroxisome_Homo sapiens_hsa041460.22071661
115Pancreatic cancer_Homo sapiens_hsa052120.20486065
116Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20468368
117Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.19964850
118Galactose metabolism_Homo sapiens_hsa000520.19724333
119Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.19415513
120beta-Alanine metabolism_Homo sapiens_hsa004100.19132647
121Bladder cancer_Homo sapiens_hsa052190.18987841
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.18747351
123Amphetamine addiction_Homo sapiens_hsa050310.18149935
124Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.17964066
125AMPK signaling pathway_Homo sapiens_hsa041520.17019129
126Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16625361
127Gap junction_Homo sapiens_hsa045400.15200326
128GABAergic synapse_Homo sapiens_hsa047270.14944464
129Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.14579298
130Colorectal cancer_Homo sapiens_hsa052100.13622892
131Alcoholism_Homo sapiens_hsa050340.12484887

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