CUL3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cullin protein family. The encoded protein plays a critical role in the polyubiquitination and subsequent degradation of specific protein substrates as the core component and scaffold protein of an E3 ubiquitin ligase complex. Complexes including the encoded protein may also play a role in late endosome maturation. Mutations in this gene are a cause of type 2E pseudohypoaldosteronism. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.15819653
2mitotic sister chromatid cohesion (GO:0007064)6.09710457
3regulation of RNA export from nucleus (GO:0046831)5.64673063
4nuclear pore organization (GO:0006999)5.49639837
5monoubiquitinated protein deubiquitination (GO:0035520)5.22525974
6histone H3-K36 demethylation (GO:0070544)5.01473769
7regulation of nucleobase-containing compound transport (GO:0032239)4.74535225
8pore complex assembly (GO:0046931)4.68083273
9cytoplasmic mRNA processing body assembly (GO:0033962)4.30320999
10piRNA metabolic process (GO:0034587)4.25456296
11synaptonemal complex assembly (GO:0007130)4.11789294
12synaptonemal complex organization (GO:0070193)4.05028586
13NLS-bearing protein import into nucleus (GO:0006607)4.02753980
14regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.81509109
15histone H3-K9 demethylation (GO:0033169)3.77907164
16acrosome assembly (GO:0001675)3.75095210
17pre-miRNA processing (GO:0031054)3.74319950
18peptidyl-lysine dimethylation (GO:0018027)3.68806130
19sister chromatid cohesion (GO:0007062)3.62382032
20gene silencing by RNA (GO:0031047)3.60819753
21regulation of NFAT protein import into nucleus (GO:0051532)3.58250218
22male meiosis (GO:0007140)3.53835085
23glucocorticoid receptor signaling pathway (GO:0042921)3.49286605
24cilium or flagellum-dependent cell motility (GO:0001539)3.43227366
25regulation of protein polyubiquitination (GO:1902914)3.42980549
26regulation of meiosis I (GO:0060631)3.36108431
27protein targeting to Golgi (GO:0000042)3.35107527
28regulation of clathrin-mediated endocytosis (GO:2000369)3.27833406
29DNA synthesis involved in DNA repair (GO:0000731)3.26071042
30corticosteroid receptor signaling pathway (GO:0031958)3.23546051
31establishment of protein localization to Golgi (GO:0072600)3.18799223
32mitotic chromosome condensation (GO:0007076)3.16679729
33regulation of centriole replication (GO:0046599)3.15071066
34interkinetic nuclear migration (GO:0022027)3.14440723
35regulation of histone H3-K27 methylation (GO:0061085)3.12204883
36retrograde transport, vesicle recycling within Golgi (GO:0000301)3.09042007
37negative regulation of DNA repair (GO:0045738)3.07148696
38regulation of spindle organization (GO:0090224)3.03405757
39regulation of DNA endoreduplication (GO:0032875)3.00301447
40nucleus organization (GO:0006997)2.99862992
41negative regulation of potassium ion transmembrane transport (GO:1901380)2.98977463
42RNA stabilization (GO:0043489)2.98135824
43mRNA stabilization (GO:0048255)2.98135824
44protein localization to kinetochore (GO:0034501)2.97748858
45phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.96702031
46positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.95883735
47regulation of Rac protein signal transduction (GO:0035020)2.95137815
48protein dealkylation (GO:0008214)2.94326609
49protein demethylation (GO:0006482)2.94326609
50regulation of chromatin silencing (GO:0031935)2.92636641
51negative regulation of NF-kappaB import into nucleus (GO:0042347)2.91884691
52regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.91589605
53positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.91589605
54nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.90872150
55heterochromatin organization (GO:0070828)2.89445118
56sister chromatid segregation (GO:0000819)2.88769208
57regulation of sister chromatid cohesion (GO:0007063)2.87737636
58plasma membrane repair (GO:0001778)2.87132872
59hippo signaling (GO:0035329)2.86273653
60protein localization to chromosome, centromeric region (GO:0071459)2.86006082
61synapsis (GO:0007129)2.82250928
62fusion of sperm to egg plasma membrane (GO:0007342)2.81776042
63chromosome organization involved in meiosis (GO:0070192)2.80751347
64* positive regulation of mitotic sister chromatid separation (GO:1901970)2.80604183
65* positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80604183
66* positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80604183
67peptidyl-threonine modification (GO:0018210)2.79381537
68gene silencing (GO:0016458)2.79340802
69DNA unwinding involved in DNA replication (GO:0006268)2.78553868
70regulation of histone H3-K9 methylation (GO:0051570)2.78192001
71meiotic nuclear division (GO:0007126)2.78038423
72negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.77657851
73regulation of histone methylation (GO:0031060)2.76995929
74embryonic body morphogenesis (GO:0010172)2.76365703
75negative regulation of histone methylation (GO:0031061)2.74764803
76regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.74269308
77positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.74269308
78peptidyl-threonine phosphorylation (GO:0018107)2.74026230
79regulation of mitotic spindle organization (GO:0060236)2.73465755
80Golgi to endosome transport (GO:0006895)2.72163655
81genitalia morphogenesis (GO:0035112)2.71645979
82regulation of chromatin binding (GO:0035561)2.70108437
83peptidyl-threonine dephosphorylation (GO:0035970)2.68326978
84membrane disassembly (GO:0030397)2.67164674
85nuclear envelope disassembly (GO:0051081)2.67164674
86positive regulation of translational initiation (GO:0045948)2.66867113
87chromosome condensation (GO:0030261)2.66489223
88peptidyl-lysine trimethylation (GO:0018023)2.65113764
89histone H3-K9 methylation (GO:0051567)2.64039757
90negative regulation of inclusion body assembly (GO:0090084)2.63258244
91male meiosis I (GO:0007141)2.62818340
92growth hormone receptor signaling pathway (GO:0060396)2.62532142
93histone H3-K4 trimethylation (GO:0080182)2.61727631
94protein localization to chromosome (GO:0034502)2.61237257
95body morphogenesis (GO:0010171)2.61199787
96N-terminal protein amino acid acetylation (GO:0006474)2.60875387
97chromatin assembly (GO:0031497)2.56649751
98hypotonic response (GO:0006971)2.56048729
99regulation of mRNA stability (GO:0043488)2.55638880
100positive regulation of histone methylation (GO:0031062)2.55252265
101epithelial cilium movement (GO:0003351)2.54364232
102mitotic nuclear envelope disassembly (GO:0007077)2.53595652
103spermatid development (GO:0007286)2.52599605
104histone lysine demethylation (GO:0070076)2.51859560
105embryonic camera-type eye morphogenesis (GO:0048596)2.51521008
106protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.50615715
107DNA packaging (GO:0006323)2.50398039
108sperm motility (GO:0030317)2.49547069
109determination of adult lifespan (GO:0008340)2.48655563
110histone H2B ubiquitination (GO:0033523)2.48013559
111paraxial mesoderm development (GO:0048339)2.47984676
112labyrinthine layer development (GO:0060711)2.47818637
113histone demethylation (GO:0016577)2.46584894
114regulation of mRNA 3-end processing (GO:0031440)2.46551860
115regulation of translational termination (GO:0006449)2.44452348
116positive regulation of catenin import into nucleus (GO:0035413)2.43639757
117insulin-like growth factor receptor signaling pathway (GO:0048009)2.42384261
118protein localization to endosome (GO:0036010)2.42032688
119negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.41781435
120positive regulation of mRNA 3-end processing (GO:0031442)2.41772493
121cellular protein complex localization (GO:0034629)2.41134496
122spindle assembly involved in mitosis (GO:0090307)2.40751278
123positive regulation of insulin receptor signaling pathway (GO:0046628)2.40610693
124negative regulation of fibroblast apoptotic process (GO:2000270)2.39581541
125skeletal muscle adaptation (GO:0043501)2.38539938
126DNA methylation involved in gamete generation (GO:0043046)2.38109272
127regulation of establishment of cell polarity (GO:2000114)2.38001895
128single strand break repair (GO:0000012)2.37332370
129regulation of RNA stability (GO:0043487)2.37254512
130sperm-egg recognition (GO:0035036)2.37161070
131oocyte development (GO:0048599)2.37143249
132nucleus localization (GO:0051647)2.35064679
133positive regulation of cellular response to insulin stimulus (GO:1900078)2.34145386
134microtubule cytoskeleton organization involved in mitosis (GO:1902850)2.33998681
135negative regulation of histone modification (GO:0031057)2.33525980
136binding of sperm to zona pellucida (GO:0007339)2.33500649
137peptidyl-lysine methylation (GO:0018022)2.31622078
138protein localization to microtubule (GO:0035372)2.29133910
139striated muscle atrophy (GO:0014891)2.29094173
140cellular response to growth hormone stimulus (GO:0071378)2.28368424
141chondrocyte development (GO:0002063)2.25262838
142histone H3-K4 methylation (GO:0051568)2.24219573
143embryonic process involved in female pregnancy (GO:0060136)2.23121250
144early endosome to late endosome transport (GO:0045022)2.22231840
145DNA conformation change (GO:0071103)2.22176926
146negative regulation of dendrite morphogenesis (GO:0050774)2.21827200
147protein export from nucleus (GO:0006611)2.21268960
148negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.20013460
149anterior/posterior axis specification, embryo (GO:0008595)2.19488212
150regulation of gene silencing (GO:0060968)2.18982928
151establishment of nucleus localization (GO:0040023)2.16502612
152histone lysine methylation (GO:0034968)2.16493049
153regulation of centrosome duplication (GO:0010824)2.16431642

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human3.98402404
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.84852495
3E2F7_22180533_ChIP-Seq_HELA_Human3.72266451
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.64136040
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.23971652
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.11775282
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.97450719
8TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.64465686
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.63153159
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34677902
11FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15446995
12HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.11859022
13ZNF263_19887448_ChIP-Seq_K562_Human1.99911337
14SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.91663117
15ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.84097975
16TP63_19390658_ChIP-ChIP_HaCaT_Human1.82165479
17* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80741997
18* TCF4_18268006_ChIP-ChIP_LS174T_Human1.78052678
19* E2F4_17652178_ChIP-ChIP_JURKAT_Human1.75717865
20ZNF274_21170338_ChIP-Seq_K562_Hela1.74216374
21FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.72699480
22ZNF217_24962896_ChIP-Seq_MCF-7_Human1.72024986
23CTNNB1_20460455_ChIP-Seq_HCT116_Human1.67205411
24SMAD_19615063_ChIP-ChIP_OVARY_Human1.64861768
25PKCTHETA_26484144_Chip-Seq_BREAST_Human1.62504909
26AR_21909140_ChIP-Seq_LNCAP_Human1.61783749
27FUS_26573619_Chip-Seq_HEK293_Human1.58136383
28AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.57303066
29POU3F2_20337985_ChIP-ChIP_501MEL_Human1.53565107
30MYB_21317192_ChIP-Seq_ERMYB_Mouse1.48372239
31Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.46719993
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46492575
33* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.46081704
34PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.45348082
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.44538938
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.42925439
37SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.42679369
38FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40043574
39BRD4_25478319_ChIP-Seq_HGPS_Human1.29711778
40WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.28348143
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.26308299
42ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25666310
43SOX9_24532713_ChIP-Seq_HFSC_Mouse1.24465459
44* FOXO3_23340844_ChIP-Seq_DLD1_Human1.23500920
45SMAD4_21799915_ChIP-Seq_A2780_Human1.23493121
46PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.22795021
47GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20805089
48AR_21572438_ChIP-Seq_LNCaP_Human1.19369601
49STAT3_23295773_ChIP-Seq_U87_Human1.19189652
50EZH2_22144423_ChIP-Seq_EOC_Human1.19161526
51STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16841013
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.16432295
53* STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.16334577
54FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.13828836
55CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.13651583
56CHD1_26751641_Chip-Seq_LNCaP_Human1.13504330
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.13336763
58SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.12818942
59TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12478715
60TBX3_20139965_ChIP-Seq_ESCs_Mouse1.12363923
61TAF15_26573619_Chip-Seq_HEK293_Human1.11818638
62TBX3_20139965_ChIP-Seq_MESCs_Mouse1.11410612
63BCAT_22108803_ChIP-Seq_LS180_Human1.11197684
64PPAR_26484153_Chip-Seq_NCI-H1993_Human1.10334537
65GATA1_22025678_ChIP-Seq_K562_Human1.09448273
66* NFIB_24661679_ChIP-Seq_LUNG_Mouse1.08933337
67TCF7_22412390_ChIP-Seq_EML_Mouse1.08718532
68PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08315300
69YAP1_20516196_ChIP-Seq_MESCs_Mouse1.08194620
70ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.08048398
71KDM2B_26808549_Chip-Seq_DND41_Human1.06244315
72* CDX2_19796622_ChIP-Seq_MESCs_Mouse1.06181671
73TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.06076266
74* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.05710494
75KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.05615318
76PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05556292
77* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05449606
78VDR_24787735_ChIP-Seq_THP-1_Human1.05096966
79EWS_26573619_Chip-Seq_HEK293_Human1.04079894
80FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.03910935
81TP53_16413492_ChIP-PET_HCT116_Human1.02443043
82TCF4_23295773_ChIP-Seq_U87_Human1.02294000
83WT1_19549856_ChIP-ChIP_CCG9911_Human1.01648728
84CDX2_22108803_ChIP-Seq_LS180_Human1.01309969
85* FLI1_27457419_Chip-Seq_LIVER_Mouse1.01131051
86GF1_26923725_Chip-Seq_HPCs_Mouse1.00982213
87* FOXA2_19822575_ChIP-Seq_HepG2_Human1.00788144
88ARNT_22903824_ChIP-Seq_MCF-7_Human1.00728785
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00454290
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00119163
91SOX2_27498859_Chip-Seq_STOMACH_Mouse0.99296811
92EP300_21415370_ChIP-Seq_HL-1_Mouse0.99239526
93* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.99117997
94ISL1_27105846_Chip-Seq_CPCs_Mouse0.99018542
95KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.99009523
96KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.99009523
97KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.99009523
98SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98478535
99GF1B_26923725_Chip-Seq_HPCs_Mouse0.98409881
100* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98382013
101CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.96510956
102* PU_27001747_Chip-Seq_BMDM_Mouse0.94585953
103RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.94327506
104* CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.93281250
105* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human0.92721223
106SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.92089370
107STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.92058336
108SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.91852228
109SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.91852228
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.91328108
111* RBPJ_22232070_ChIP-Seq_NCS_Mouse0.90771849
112UBF1/2_26484160_Chip-Seq_HMECs_Human0.90771514
113IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.90596530
114CBP_20019798_ChIP-Seq_JUKART_Human0.90596530
115RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.90459033
116* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.90312464
117CJUN_26792858_Chip-Seq_BT549_Human0.90172703
118STAT6_21828071_ChIP-Seq_BEAS2B_Human0.89842643
119* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.89628648
120* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.89332058
121TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89300338
122NRF2_20460467_ChIP-Seq_MEFs_Mouse0.88586307
123NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.88586307
124WDR5_24793694_ChIP-Seq_LNCAP_Human0.87829355
125CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.87741027
126RUNX_20019798_ChIP-Seq_JUKART_Human0.87646897
127AHR_22903824_ChIP-Seq_MCF-7_Human0.87463409
128CLOCK_20551151_ChIP-Seq_293T_Human0.87378559
129SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87341505
130GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.86588247
131ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.86501426
132FLI1_21867929_ChIP-Seq_TH2_Mouse0.86405758
133* TP63_23658742_ChIP-Seq_EP156T_Human0.86181432
134MYC_22102868_ChIP-Seq_BL_Human0.85981026
135SOX2_21211035_ChIP-Seq_LN229_Gbm0.84789225
136RXR_22108803_ChIP-Seq_LS180_Human0.84340819

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle3.98919914
2MP0008877_abnormal_DNA_methylation3.33171864
3MP0005409_darkened_coat_color3.20649802
4MP0010352_gastrointestinal_tract_polyps2.90913005
5MP0000569_abnormal_digit_pigmentation2.86945026
6MP0002877_abnormal_melanocyte_morpholog2.80421967
7MP0003705_abnormal_hypodermis_morpholog2.78511164
8MP0005076_abnormal_cell_differentiation2.65442955
9MP0010307_abnormal_tumor_latency2.23329705
10MP0005410_abnormal_fertilization2.17534034
11MP0005187_abnormal_penis_morphology2.09891996
12MP0003787_abnormal_imprinting2.09172673
13MP0005451_abnormal_body_composition1.94979017
14MP0002796_impaired_skin_barrier1.87615779
15MP0008057_abnormal_DNA_replication1.84579694
16MP0004145_abnormal_muscle_electrophysio1.82267039
17MP0000733_abnormal_muscle_development1.80234358
18MP0005248_abnormal_Harderian_gland1.79538022
19MP0003123_paternal_imprinting1.75391320
20MP0005623_abnormal_meninges_morphology1.70729147
21MP0002009_preneoplasia1.67394068
22MP0003890_abnormal_embryonic-extraembry1.63076540
23MP0004185_abnormal_adipocyte_glucose1.62541400
24MP0004264_abnormal_extraembryonic_tissu1.58142725
25MP0010094_abnormal_chromosome_stability1.54843189
26MP0010678_abnormal_skin_adnexa1.54421819
27MP0001730_embryonic_growth_arrest1.53999138
28MP0003121_genomic_imprinting1.53463633
29MP0003300_gastrointestinal_ulcer1.52882998
30MP0001929_abnormal_gametogenesis1.51364022
31MP0004197_abnormal_fetal_growth/weight/1.50588154
32MP0003453_abnormal_keratinocyte_physiol1.46461178
33* MP0002084_abnormal_developmental_patter1.46196194
34MP0001293_anophthalmia1.45580382
35MP0003828_pulmonary_edema1.44952433
36MP0003698_abnormal_male_reproductive1.44904360
37MP0000537_abnormal_urethra_morphology1.44699741
38MP0004233_abnormal_muscle_weight1.40681902
39MP0004087_abnormal_muscle_fiber1.39392301
40MP0009780_abnormal_chondrocyte_physiolo1.39302979
41MP0004808_abnormal_hematopoietic_stem1.37436702
42* MP0002086_abnormal_extraembryonic_tissu1.35358183
43MP0009053_abnormal_anal_canal1.34972476
44MP0002088_abnormal_embryonic_growth/wei1.34879439
45MP0003984_embryonic_growth_retardation1.33616131
46MP0002210_abnormal_sex_determination1.33423360
47MP0005380_embryogenesis_phenotype1.33114563
48MP0001672_abnormal_embryogenesis/_devel1.33114563
49MP0009703_decreased_birth_body1.32266806
50MP0001299_abnormal_eye_distance/1.30396952
51MP0009672_abnormal_birth_weight1.30224107
52MP0003111_abnormal_nucleus_morphology1.29841178
53MP0003941_abnormal_skin_development1.28905503
54MP0005367_renal/urinary_system_phenotyp1.28740936
55MP0000516_abnormal_urinary_system1.28740936
56MP0004084_abnormal_cardiac_muscle1.24572187
57MP0002697_abnormal_eye_size1.23858332
58MP0003950_abnormal_plasma_membrane1.23374693
59MP0002396_abnormal_hematopoietic_system1.19475523
60MP0000350_abnormal_cell_proliferation1.19253325
61* MP0001697_abnormal_embryo_size1.19019064
62MP0002006_tumorigenesis1.17688633
63MP0005666_abnormal_adipose_tissue1.16199448
64MP0001188_hyperpigmentation1.15770282
65MP0001915_intracranial_hemorrhage1.15558421
66MP0002269_muscular_atrophy1.15306488
67MP0005275_abnormal_skin_tensile1.14803440
68MP0008007_abnormal_cellular_replicative1.14742802
69MP0003566_abnormal_cell_adhesion1.14071361
70MP0000428_abnormal_craniofacial_morphol1.13034185
71MP0001145_abnormal_male_reproductive1.12687032
72MP0004036_abnormal_muscle_relaxation1.12476874
73MP0003045_fibrosis1.12005855
74MP0010630_abnormal_cardiac_muscle1.11893723
75MP0008961_abnormal_basal_metabolism1.11556327
76MP0000427_abnormal_hair_cycle1.10363927
77MP0002106_abnormal_muscle_physiology1.10312320
78MP0003693_abnormal_embryo_hatching1.10017605
79MP0004130_abnormal_muscle_cell1.08494421
80MP0002234_abnormal_pharynx_morphology1.07439803
81MP0003935_abnormal_craniofacial_develop1.07043234
82MP0002085_abnormal_embryonic_tissue1.06302235
83* MP0003077_abnormal_cell_cycle1.05746909
84* MP0004957_abnormal_blastocyst_morpholog1.03225778
85MP0006072_abnormal_retinal_apoptosis1.03084984
86MP0003115_abnormal_respiratory_system1.00976866
87MP0002089_abnormal_postnatal_growth/wei1.00923092
88MP0003122_maternal_imprinting1.00276826
89MP0000759_abnormal_skeletal_muscle1.00041282
90MP0002138_abnormal_hepatobiliary_system0.98624646
91MP0000653_abnormal_sex_gland0.97100127
92* MP0002080_prenatal_lethality0.96564963
93MP0000747_muscle_weakness0.95527643
94MP0003646_muscle_fatigue0.95225633
95MP0000751_myopathy0.94658614
96MP0003567_abnormal_fetal_cardiomyocyte0.94641485
97MP0003221_abnormal_cardiomyocyte_apopto0.94611554
98MP0002092_abnormal_eye_morphology0.94563342
99MP0002925_abnormal_cardiovascular_devel0.93058611
100MP0000383_abnormal_hair_follicle0.92937180
101MP0006138_congestive_heart_failure0.91875530
102MP0010368_abnormal_lymphatic_system0.91684162
103MP0005620_abnormal_muscle_contractility0.91639976
104MP0004484_altered_response_of0.90971546
105MP0001784_abnormal_fluid_regulation0.90351621
106MP0000749_muscle_degeneration0.89657447
107MP0002896_abnormal_bone_mineralization0.88772266
108MP0005621_abnormal_cell_physiology0.88404722
109MP0005369_muscle_phenotype0.88241920
110MP0002166_altered_tumor_susceptibility0.87685109
111MP0002108_abnormal_muscle_morphology0.85931740
112MP0005375_adipose_tissue_phenotype0.85347551
113MP0005501_abnormal_skin_physiology0.85273787
114MP0003755_abnormal_palate_morphology0.85247329
115MP0000266_abnormal_heart_morphology0.84495942
116MP0000432_abnormal_head_morphology0.83425754
117MP0009115_abnormal_fat_cell0.82306506
118MP0003119_abnormal_digestive_system0.81599248
119MP0003091_abnormal_cell_migration0.80983186
120MP0001879_abnormal_lymphatic_vessel0.80868183
121MP0003937_abnormal_limbs/digits/tail_de0.80677080
122MP0002837_dystrophic_cardiac_calcinosis0.79781986
123MP0003763_abnormal_thymus_physiology0.79613157
124MP0002161_abnormal_fertility/fecundity0.79504271
125MP0002060_abnormal_skin_morphology0.77564131
126MP0001216_abnormal_epidermal_layer0.76495917
127MP0005310_abnormal_salivary_gland0.76277585
128MP0000627_abnormal_mammary_gland0.74880781

Predicted human phenotypes

RankGene SetZ-score
1Papillary thyroid carcinoma (HP:0002895)3.84224683
2Volvulus (HP:0002580)3.70162007
3Abnormality of the left ventricular outflow tract (HP:0011103)3.44223837
4Subaortic stenosis (HP:0001682)3.44223837
5Absent eyebrow (HP:0002223)3.28333740
6Pelvic girdle muscle weakness (HP:0003749)3.27129079
7Shoulder girdle muscle weakness (HP:0003547)3.15565523
8Exercise-induced muscle cramps (HP:0003710)2.95271134
9Subacute progressive viral hepatitis (HP:0006572)2.86236506
10Abnormality of the musculature of the pelvis (HP:0001469)2.85601795
11Abnormality of the hip-girdle musculature (HP:0001445)2.85601795
12Macroorchidism (HP:0000053)2.83192568
13Thyroid carcinoma (HP:0002890)2.64285259
14Muscle fiber inclusion bodies (HP:0100299)2.61333271
15Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.56435057
16Aplasia/Hypoplasia of the sternum (HP:0006714)2.53185707
17Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.48705230
18Distal arthrogryposis (HP:0005684)2.48426186
19Truncal obesity (HP:0001956)2.46206025
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.44652403
21Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.44304049
22Curly hair (HP:0002212)2.40320024
23Exercise-induced myalgia (HP:0003738)2.34555309
24Midline defect of the nose (HP:0004122)2.33421380
25Microglossia (HP:0000171)2.33419866
26Hyporeflexia of lower limbs (HP:0002600)2.32541223
27Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.31520712
28Difficulty running (HP:0009046)2.29927872
29Menstrual irregularities (HP:0000858)2.29819546
30Resting tremor (HP:0002322)2.29480989
31Abnormality of chromosome segregation (HP:0002916)2.27685185
32Abnormality of the lower motor neuron (HP:0002366)2.25866245
33Nephroblastoma (Wilms tumor) (HP:0002667)2.25605124
34Short 4th metacarpal (HP:0010044)2.25207921
35Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.25207921
36Biliary tract neoplasm (HP:0100574)2.24187450
37Rectal prolapse (HP:0002035)2.23012182
38Heterotopia (HP:0002282)2.22753796
39Leiomyosarcoma (HP:0100243)2.22061281
40Uterine leiomyosarcoma (HP:0002891)2.22061281
41Vertebral arch anomaly (HP:0008438)2.21201042
42Morphological abnormality of the middle ear (HP:0008609)2.20946446
43Enlarged penis (HP:0000040)2.20468368
44Ulnar deviation of the wrist (HP:0003049)2.16447774
45Abnormality of the distal phalanx of the thumb (HP:0009617)2.12109502
46Embryonal renal neoplasm (HP:0011794)2.11641540
47Asymmetry of the thorax (HP:0001555)2.11233200
48Muscle hypertrophy of the lower extremities (HP:0008968)2.10375498
49Increased connective tissue (HP:0009025)2.08471764
50Peripheral hypomyelination (HP:0007182)2.07734233
51Absent frontal sinuses (HP:0002688)2.07516956
52Hypoplastic labia majora (HP:0000059)2.05112745
53Type 1 muscle fiber predominance (HP:0003803)2.03634497
54Difficulty climbing stairs (HP:0003551)2.03419736
55Abnormality of the nasal septum (HP:0000419)2.03291859
56Ankyloglossia (HP:0010296)2.02988377
57Calf muscle hypertrophy (HP:0008981)2.02532255
58Abnormality of the pubic bones (HP:0003172)1.99733549
59Slow saccadic eye movements (HP:0000514)1.98948916
60Bifid tongue (HP:0010297)1.98628688
61Nemaline bodies (HP:0003798)1.97801965
62Overgrowth (HP:0001548)1.96761760
63Facial hemangioma (HP:0000329)1.95994016
64Abnormal finger flexion creases (HP:0006143)1.94617450
65Rhabdomyosarcoma (HP:0002859)1.93945213
66Arterial tortuosity (HP:0005116)1.93101562
67* Hyperkalemia (HP:0002153)1.91063460
68Thickened helices (HP:0000391)1.90991270
69Hypoplastic ischia (HP:0003175)1.90939418
70Limb-girdle muscle weakness (HP:0003325)1.90334256
71Gonadotropin excess (HP:0000837)1.90332865
72Abnormality of the labia majora (HP:0012881)1.90039152
73Skull defect (HP:0001362)1.89851119
74Osteolytic defects of the hand bones (HP:0009699)1.89585456
75Osteolytic defects of the phalanges of the hand (HP:0009771)1.89585456
76Cubitus valgus (HP:0002967)1.89245106
77Progressive external ophthalmoplegia (HP:0000590)1.89148084
78Abnormality of the calcaneus (HP:0008364)1.88923670
79Abnormality of the astrocytes (HP:0100707)1.88646605
80Astrocytoma (HP:0009592)1.88646605
81Transitional cell carcinoma of the bladder (HP:0006740)1.88153611
82Hematochezia (HP:0002573)1.87706862
83Absent phalangeal crease (HP:0006109)1.84868574
84Neonatal hypoglycemia (HP:0001998)1.84434792
85Relative macrocephaly (HP:0004482)1.84217891
86Bilateral microphthalmos (HP:0007633)1.84085488
87Dysmetric saccades (HP:0000641)1.84015368
88Bladder carcinoma (HP:0002862)1.82503975
89Bladder neoplasm (HP:0009725)1.82503975
90Genetic anticipation (HP:0003743)1.82498060
91Deep philtrum (HP:0002002)1.81501329
92Breast carcinoma (HP:0003002)1.81094237
93Absent/shortened dynein arms (HP:0200106)1.80943157
94Dynein arm defect of respiratory motile cilia (HP:0012255)1.80943157
95Cutaneous finger syndactyly (HP:0010554)1.80871739
96Papilledema (HP:0001085)1.80050587
97Cutaneous melanoma (HP:0012056)1.79992410
98Obsessive-compulsive behavior (HP:0000722)1.79970632
99Termporal pattern (HP:0011008)1.79968979
100Insidious onset (HP:0003587)1.79968979
101Absent eyelashes (HP:0000561)1.78244752
102Deep palmar crease (HP:0006191)1.74946580
103Sandal gap (HP:0001852)1.74678724
104Tetraparesis (HP:0002273)1.73984352
105Narrow palate (HP:0000189)1.73768727
106Malignant gastrointestinal tract tumors (HP:0006749)1.72678346
107Gastrointestinal carcinoma (HP:0002672)1.72678346
108Abnormality of the fingertips (HP:0001211)1.72605090
109Calcaneovalgus deformity (HP:0001848)1.72267584
110Muscle fiber splitting (HP:0003555)1.72085651
111Facial cleft (HP:0002006)1.72039058
112EMG: myopathic abnormalities (HP:0003458)1.70798215
113Amyotrophic lateral sclerosis (HP:0007354)1.70531673
114Abnormality of the phalanges of the hallux (HP:0010057)1.69782779
115Asymmetric septal hypertrophy (HP:0001670)1.69474735
116Central scotoma (HP:0000603)1.69149402
117Increased nuchal translucency (HP:0010880)1.69130570
118Syringomyelia (HP:0003396)1.68854908
119Spinal cord lesions (HP:0100561)1.68854908
120Thick eyebrow (HP:0000574)1.68778530
121Disinhibition (HP:0000734)1.67612743
122Neoplasm of striated muscle (HP:0009728)1.67196010
123Flat acetabular roof (HP:0003180)1.67027673
124Abnormality of the ischium (HP:0003174)1.67007398
125Missing ribs (HP:0000921)1.66512537
126Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.65999598
127Bicornuate uterus (HP:0000813)1.65049949
128Lip pit (HP:0100267)1.64757146
129Abnormality of the 4th metacarpal (HP:0010012)1.64675969
130Abnormality of the salivary glands (HP:0010286)1.64511915
131Medulloblastoma (HP:0002885)1.64039781
132Male infertility (HP:0003251)1.63949569
133Neoplasm of the adrenal cortex (HP:0100641)1.63334846
134Low anterior hairline (HP:0000294)1.62896633
135Rimmed vacuoles (HP:0003805)1.62430383
136Dislocated radial head (HP:0003083)1.62398035
137Acute myeloid leukemia (HP:0004808)1.62043136
138Deviation of the thumb (HP:0009603)1.60917749
139Uterine neoplasm (HP:0010784)1.60719100
140Vascular tortuosity (HP:0004948)1.60394750
141Proximal amyotrophy (HP:0007126)1.60180872
142Aplasia/Hypoplasia of the scapulae (HP:0006713)1.59648725
143Hypoplastic scapulae (HP:0000882)1.59648725
144Cystic hygroma (HP:0000476)1.59592085
145Prominent nose (HP:0000448)1.58453572
146Long eyelashes (HP:0000527)1.58035124
147Inappropriate behavior (HP:0000719)1.57395893
148Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.56372705
149Short 1st metacarpal (HP:0010034)1.56372705
150Abnormality of skeletal muscle fiber size (HP:0012084)1.55943199
151Abnormality of incisor morphology (HP:0011063)1.54072291
152Cafe-au-lait spot (HP:0000957)1.53583224
153Mitral valve prolapse (HP:0001634)1.53573015

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.35447105
2MAP3K103.14434750
3FRK2.90879677
4LATS12.89439485
5PRKD32.89392122
6PDK32.85896346
7PDK42.85896346
8CDC72.68480450
9PNCK2.48254772
10TAF12.34704253
11NEK22.10654049
12MAP3K21.91204750
13STK241.86324460
14FGFR31.83124153
15TTN1.79116411
16PTK2B1.74410033
17STK31.73237998
18DMPK1.70542238
19PKN21.70131698
20SMG11.68597571
21BRSK21.67447703
22PIK3CG1.63055746
23TRIB31.57510285
24LATS21.50806271
25BRD41.49362473
26CAMK1G1.47723016
27PTK61.46995419
28NEK11.45957441
29ALK1.44758732
30MAP3K131.43811247
31PDK21.37372601
32PDGFRA1.37002390
33SCYL21.36488532
34ERBB31.32603625
35WNK11.30944857
36MAP3K41.29709501
37TNIK1.28178372
38PLK31.28059640
39MAP3K141.27053829
40PRPF4B1.23376214
41CDK61.21812366
42TESK11.20402489
43FGFR21.20080763
44BLK1.18920681
45RET1.15190207
46MAP2K41.11772817
47RIPK11.09098713
48MET1.06711556
49NLK1.04160615
50KSR21.03722278
51STK381.03474645
52YES10.99573338
53SGK30.99428010
54PLK20.98100717
55CHEK10.95488806
56TRPM70.93607053
57PHKG20.93336557
58PHKG10.93336557
59TYRO30.92402676
60ATM0.92351395
61CDK90.92334757
62PDGFRB0.91597014
63CDK40.90156665
64OBSCN0.89111351
65CAMK1D0.84060410
66RPS6KB20.83686675
67RPS6KB10.83541195
68DYRK30.83175113
69FGFR40.82017001
70PLK40.81740008
71MTOR0.81511549
72MELK0.80549676
73SGK20.79664819
74FGFR10.77341742
75STK38L0.77080378
76SGK4940.76525704
77SGK2230.76525704
78FGR0.75778017
79FER0.74958191
80MAP3K50.73761316
81MST1R0.73595378
82MAP3K90.72729567
83BRAF0.69054285
84STK100.69023395
85NEK60.67398139
86WNK40.66765393
87MKNK10.66537040
88CHEK20.66225156
89STK110.66017000
90NEK90.65199187
91MARK10.65106904
92RPS6KA40.64760088
93WEE10.64194996
94CDK20.63605340
95TTK0.63384169
96MKNK20.62330425
97PLK10.61623171
98CDK190.60424932
99WNK30.59982068
100IRAK20.59689950
101MAPK100.58444941
102MOS0.57911322
103MAP3K70.57267524
104IRAK10.56968418
105PRKCH0.56913349
106AKT30.56697741
107MAP3K60.56590420
108CSNK1D0.55961944
109BRSK10.55482992
110MAP3K10.54482472
111MARK30.53989908
112STK40.52991001
113CDK10.52489244
114ATR0.52143060
115PRKDC0.52044453
116PRKAA10.51765080
117SGK10.51742014
118NTRK30.51723376
119CSNK1E0.50653581
120EEF2K0.49979460
121KSR10.49790099
122MST40.48885003
123MAPK140.48718247
124ACVR1B0.47624407
125MINK10.47554766
126MAP2K30.46344300
127EIF2AK30.45509728
128NUAK10.45339655
129PASK0.45006331
130LMTK20.44440198
131ICK0.44300169
132DYRK1A0.44225314
133PDK10.43627585
134DYRK1B0.43445472
135EIF2AK20.43354722
136RPS6KA30.43088555
137CSK0.42966297
138* GSK3B0.41576721
139BMX0.41044727
140MAP3K80.39675432
141EGFR0.39600289
142JAK10.39381271
143MAPK70.38813026
144PBK0.38119558

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005243.51304427
2Dorso-ventral axis formation_Homo sapiens_hsa043202.19410563
3mRNA surveillance pathway_Homo sapiens_hsa030151.72770275
4B cell receptor signaling pathway_Homo sapiens_hsa046621.71164335
5Long-term potentiation_Homo sapiens_hsa047201.67707797
6mTOR signaling pathway_Homo sapiens_hsa041501.63346333
7Adherens junction_Homo sapiens_hsa045201.62695151
8Oocyte meiosis_Homo sapiens_hsa041141.62107876
9Carbohydrate digestion and absorption_Homo sapiens_hsa049731.57488482
10Type II diabetes mellitus_Homo sapiens_hsa049301.57314710
11Glucagon signaling pathway_Homo sapiens_hsa049221.54302112
12Fatty acid biosynthesis_Homo sapiens_hsa000611.46312056
13Glioma_Homo sapiens_hsa052141.45240757
14Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.39694699
15Endometrial cancer_Homo sapiens_hsa052131.38642006
16Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.36331366
17Thyroid hormone signaling pathway_Homo sapiens_hsa049191.34800084
18Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.34396196
19Acute myeloid leukemia_Homo sapiens_hsa052211.33705459
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.27646625
21Estrogen signaling pathway_Homo sapiens_hsa049151.26173253
22Phototransduction_Homo sapiens_hsa047441.25409148
23MicroRNAs in cancer_Homo sapiens_hsa052061.24715196
24RNA transport_Homo sapiens_hsa030131.24542255
25* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.24347155
26Insulin signaling pathway_Homo sapiens_hsa049101.23215632
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.20823107
28Chronic myeloid leukemia_Homo sapiens_hsa052201.18924189
29FoxO signaling pathway_Homo sapiens_hsa040681.14029750
30Phosphatidylinositol signaling system_Homo sapiens_hsa040701.12723965
31Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.12470541
32Renal cell carcinoma_Homo sapiens_hsa052111.11510259
33Thyroid cancer_Homo sapiens_hsa052161.10265528
34Cell cycle_Homo sapiens_hsa041101.09909624
35Renin secretion_Homo sapiens_hsa049241.08447404
36cGMP-PKG signaling pathway_Homo sapiens_hsa040221.08250883
37Proteoglycans in cancer_Homo sapiens_hsa052051.07428455
38Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.07305097
39Focal adhesion_Homo sapiens_hsa045101.06795596
40Prostate cancer_Homo sapiens_hsa052151.06733477
41Colorectal cancer_Homo sapiens_hsa052101.06433098
42Insulin resistance_Homo sapiens_hsa049311.06151917
43Non-small cell lung cancer_Homo sapiens_hsa052231.06086576
44Amphetamine addiction_Homo sapiens_hsa050311.03633293
45Oxytocin signaling pathway_Homo sapiens_hsa049211.02955231
46Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00723447
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.00503973
48Hepatitis B_Homo sapiens_hsa051611.00153562
49Neurotrophin signaling pathway_Homo sapiens_hsa047220.99930009
50Bladder cancer_Homo sapiens_hsa052190.99016975
51TGF-beta signaling pathway_Homo sapiens_hsa043500.98518876
52Prolactin signaling pathway_Homo sapiens_hsa049170.98336779
53Tight junction_Homo sapiens_hsa045300.98328810
54VEGF signaling pathway_Homo sapiens_hsa043700.97525997
55ErbB signaling pathway_Homo sapiens_hsa040120.96480796
56Non-homologous end-joining_Homo sapiens_hsa034500.96225913
57Insulin secretion_Homo sapiens_hsa049110.96193805
58Hippo signaling pathway_Homo sapiens_hsa043900.95735221
59Measles_Homo sapiens_hsa051620.95626617
60Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.94386476
61Inositol phosphate metabolism_Homo sapiens_hsa005620.93975586
62GnRH signaling pathway_Homo sapiens_hsa049120.92978634
63Small cell lung cancer_Homo sapiens_hsa052220.92123937
64Pancreatic cancer_Homo sapiens_hsa052120.91262009
65AMPK signaling pathway_Homo sapiens_hsa041520.90880377
66Dopaminergic synapse_Homo sapiens_hsa047280.89851355
67Viral myocarditis_Homo sapiens_hsa054160.89551645
68Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.89212945
69Wnt signaling pathway_Homo sapiens_hsa043100.86483193
70Sphingolipid signaling pathway_Homo sapiens_hsa040710.85082510
71Influenza A_Homo sapiens_hsa051640.84274775
72MAPK signaling pathway_Homo sapiens_hsa040100.83387512
73Gastric acid secretion_Homo sapiens_hsa049710.82924845
74Leukocyte transendothelial migration_Homo sapiens_hsa046700.82203855
75Aldosterone synthesis and secretion_Homo sapiens_hsa049250.82125491
76Platelet activation_Homo sapiens_hsa046110.81187082
77Notch signaling pathway_Homo sapiens_hsa043300.80932527
78Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80916953
79Hepatitis C_Homo sapiens_hsa051600.80696642
80Antigen processing and presentation_Homo sapiens_hsa046120.80459270
81Osteoclast differentiation_Homo sapiens_hsa043800.80238187
82Jak-STAT signaling pathway_Homo sapiens_hsa046300.79083421
83AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78830476
84Nitrogen metabolism_Homo sapiens_hsa009100.78768413
85Thyroid hormone synthesis_Homo sapiens_hsa049180.78168726
86Circadian rhythm_Homo sapiens_hsa047100.78097133
87Amoebiasis_Homo sapiens_hsa051460.76965309
88Melanogenesis_Homo sapiens_hsa049160.76775515
89Phospholipase D signaling pathway_Homo sapiens_hsa040720.75928381
90Long-term depression_Homo sapiens_hsa047300.75906440
91Dilated cardiomyopathy_Homo sapiens_hsa054140.75718088
92Olfactory transduction_Homo sapiens_hsa047400.74840914
93Lysine degradation_Homo sapiens_hsa003100.74718865
94Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.74357600
95Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.73170433
96Herpes simplex infection_Homo sapiens_hsa051680.73115988
97Hedgehog signaling pathway_Homo sapiens_hsa043400.72784820
98Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.72554747
99TNF signaling pathway_Homo sapiens_hsa046680.72539681
100HIF-1 signaling pathway_Homo sapiens_hsa040660.71879002
101Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70548170
102T cell receptor signaling pathway_Homo sapiens_hsa046600.69323837
103Transcriptional misregulation in cancer_Homo sapiens_hsa052020.69198960
104cAMP signaling pathway_Homo sapiens_hsa040240.69149547
105HTLV-I infection_Homo sapiens_hsa051660.68805048
106Cholinergic synapse_Homo sapiens_hsa047250.68646947
107Endocytosis_Homo sapiens_hsa041440.67279989
108Viral carcinogenesis_Homo sapiens_hsa052030.67120788
109NF-kappa B signaling pathway_Homo sapiens_hsa040640.66949690
110Choline metabolism in cancer_Homo sapiens_hsa052310.65922401
111p53 signaling pathway_Homo sapiens_hsa041150.65852518
112Circadian entrainment_Homo sapiens_hsa047130.65161003
113Toxoplasmosis_Homo sapiens_hsa051450.62742231
114Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60935169
115Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.60810039
116Melanoma_Homo sapiens_hsa052180.59913718
117Adipocytokine signaling pathway_Homo sapiens_hsa049200.59793779
118Gap junction_Homo sapiens_hsa045400.59741153
119Vascular smooth muscle contraction_Homo sapiens_hsa042700.59216458
120Pathways in cancer_Homo sapiens_hsa052000.59058636
121Basal cell carcinoma_Homo sapiens_hsa052170.58398026
122Apoptosis_Homo sapiens_hsa042100.56149303
123RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.55562482
124Leishmaniasis_Homo sapiens_hsa051400.54210480

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