CUL4A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins (Liu et al., 2009 [PubMed 19481525]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.83019973
2nuclear pore organization (GO:0006999)5.70943746
3pore complex assembly (GO:0046931)4.90627519
4mitotic chromosome condensation (GO:0007076)4.89457969
5mitotic sister chromatid cohesion (GO:0007064)4.42543399
6homocysteine metabolic process (GO:0050667)4.34176686
7muscle filament sliding (GO:0030049)4.29068190
8actin-myosin filament sliding (GO:0033275)4.29068190
9protein carboxylation (GO:0018214)4.28165088
10peptidyl-glutamic acid carboxylation (GO:0017187)4.28165088
11positive regulation of fatty acid beta-oxidation (GO:0032000)4.23041924
12DNA unwinding involved in DNA replication (GO:0006268)4.15856953
13lysine catabolic process (GO:0006554)4.14174541
14lysine metabolic process (GO:0006553)4.14174541
15L-phenylalanine catabolic process (GO:0006559)4.06549787
16erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.06549787
17tryptophan catabolic process (GO:0006569)4.06074152
18indole-containing compound catabolic process (GO:0042436)4.06074152
19indolalkylamine catabolic process (GO:0046218)4.06074152
20kynurenine metabolic process (GO:0070189)4.05791353
21aromatic amino acid family catabolic process (GO:0009074)4.03639871
22triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.96665936
23tryptophan metabolic process (GO:0006568)3.92680044
24alpha-linolenic acid metabolic process (GO:0036109)3.92073534
25regulation of protein activation cascade (GO:2000257)3.89177337
26fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.87533913
27erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.86606406
28L-phenylalanine metabolic process (GO:0006558)3.86606406
29urea cycle (GO:0000050)3.84887412
30urea metabolic process (GO:0019627)3.84887412
31ribosome assembly (GO:0042255)3.84810642
32phospholipid homeostasis (GO:0055091)3.74495558
33regulation of fibrinolysis (GO:0051917)3.70438669
34regulation of complement activation (GO:0030449)3.69387326
35negative regulation of fibrinolysis (GO:0051918)3.69152412
36positive regulation of fatty acid oxidation (GO:0046321)3.65705362
37complement activation, alternative pathway (GO:0006957)3.64143580
38actin-mediated cell contraction (GO:0070252)3.62707613
39high-density lipoprotein particle remodeling (GO:0034375)3.56506822
40regulation of fatty acid beta-oxidation (GO:0031998)3.52615534
41fatty acid transmembrane transport (GO:1902001)3.50000246
42regulation of RNA export from nucleus (GO:0046831)3.49427497
43amino-acid betaine metabolic process (GO:0006577)3.46791912
44cellular protein complex localization (GO:0034629)3.46184190
45bile acid biosynthetic process (GO:0006699)3.45648606
46glyoxylate metabolic process (GO:0046487)3.43349215
47carnitine shuttle (GO:0006853)3.42410516
48nitrogen cycle metabolic process (GO:0071941)3.42291012
49reverse cholesterol transport (GO:0043691)3.40963871
50IMP metabolic process (GO:0046040)3.40391669
51sarcoplasmic reticulum calcium ion transport (GO:0070296)3.40171617
52negative regulation of lipase activity (GO:0060192)3.37926276
53embryonic retina morphogenesis in camera-type eye (GO:0060059)3.34037939
54skeletal muscle contraction (GO:0003009)3.32091710
55triglyceride homeostasis (GO:0070328)3.30945681
56acylglycerol homeostasis (GO:0055090)3.30945681
57glycogen catabolic process (GO:0005980)3.28338198
58cellular hyperosmotic response (GO:0071474)3.25722337
59regulation of triglyceride catabolic process (GO:0010896)3.23675672
60dicarboxylic acid biosynthetic process (GO:0043650)3.23288510
61positive regulation of lipid catabolic process (GO:0050996)3.22179953
62DNA synthesis involved in DNA repair (GO:0000731)3.20008201
63negative regulation of protein activation cascade (GO:2000258)3.18281287
64formation of translation preinitiation complex (GO:0001731)3.18239769
65cysteine metabolic process (GO:0006534)3.17657087
66regulation of translational fidelity (GO:0006450)3.15674853
67plasma lipoprotein particle clearance (GO:0034381)3.15012868
68bile acid metabolic process (GO:0008206)3.11613856
69regulation of sequestering of triglyceride (GO:0010889)3.11552268
70fatty acid beta-oxidation (GO:0006635)3.10302385
71linoleic acid metabolic process (GO:0043651)3.08056996
72regulation of nucleobase-containing compound transport (GO:0032239)3.05393876
73embryonic process involved in female pregnancy (GO:0060136)3.04740196
74sulfur amino acid catabolic process (GO:0000098)3.03069113
75imidazole-containing compound metabolic process (GO:0052803)3.02895963
76actin filament-based movement (GO:0030048)3.02436835
77positive regulation of chromosome segregation (GO:0051984)3.02221563
78valine metabolic process (GO:0006573)3.02135604
79phospholipid efflux (GO:0033700)3.02133016
802-oxoglutarate metabolic process (GO:0006103)3.01018075
81glucan catabolic process (GO:0009251)3.00972510
82serine family amino acid catabolic process (GO:0009071)3.00355443
83plasma lipoprotein particle remodeling (GO:0034369)2.96623415
84protein-lipid complex remodeling (GO:0034368)2.96623415
85macromolecular complex remodeling (GO:0034367)2.96623415
86fatty acid oxidation (GO:0019395)2.96588601
87sister chromatid cohesion (GO:0007062)2.96376472
88alpha-amino acid catabolic process (GO:1901606)2.95988878
89DNA duplex unwinding (GO:0032508)2.95885679
90regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.95720810
91regulation of translational termination (GO:0006449)2.95175545
92negative regulation of necroptotic process (GO:0060546)2.93252523
93regulation of sister chromatid cohesion (GO:0007063)2.91701709
94sarcomere organization (GO:0045214)2.91577530
95regulation of bile acid biosynthetic process (GO:0070857)2.90569143
96lipoprotein metabolic process (GO:0042157)2.89902805
97positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.89559094
98positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.89559094
99positive regulation of mitotic sister chromatid separation (GO:1901970)2.89559094
100lipid oxidation (GO:0034440)2.88388657
101cellular polysaccharide catabolic process (GO:0044247)2.86634466
102protein complex localization (GO:0031503)2.86582499
103mitotic nuclear envelope disassembly (GO:0007077)2.84780105
104cellular modified amino acid catabolic process (GO:0042219)2.84151799
105indolalkylamine metabolic process (GO:0006586)2.83533753
106regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.83446042
107tyrosine metabolic process (GO:0006570)2.83146442
108regulation of fatty acid oxidation (GO:0046320)2.82132081
109plasma lipoprotein particle assembly (GO:0034377)2.81439881
110epoxygenase P450 pathway (GO:0019373)2.80973573
111nuclear envelope disassembly (GO:0051081)2.80848857
112membrane disassembly (GO:0030397)2.80848857
113iron ion import (GO:0097286)2.80317360
114COPI coating of Golgi vesicle (GO:0048205)2.79653105
115Golgi transport vesicle coating (GO:0048200)2.79653105
116nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.79001434
117DNA geometric change (GO:0032392)2.78776840
118negative regulation of DNA repair (GO:0045738)2.78706061
119carnitine metabolic process (GO:0009437)2.78596896
120histone H3-K36 demethylation (GO:0070544)2.77502997
121aromatic amino acid family metabolic process (GO:0009072)2.76420854
122regulation of mitotic spindle organization (GO:0060236)2.75188814
123negative regulation of complement activation (GO:0045916)2.75177071
124cell-substrate adherens junction assembly (GO:0007045)2.75042112
125focal adhesion assembly (GO:0048041)2.75042112
126insulin-like growth factor receptor signaling pathway (GO:0048009)2.74105725
127positive regulation of glycolytic process (GO:0045821)2.73975521
128fibrinolysis (GO:0042730)2.73842275
129cholesterol efflux (GO:0033344)2.73684895
130regulation of NFAT protein import into nucleus (GO:0051532)2.73310068
131meiotic chromosome segregation (GO:0045132)2.73202651
132protein export from nucleus (GO:0006611)2.71623355
133short-chain fatty acid metabolic process (GO:0046459)2.71548190
134cellular glucuronidation (GO:0052695)2.71032208
135cellular biogenic amine catabolic process (GO:0042402)2.70461406
136amine catabolic process (GO:0009310)2.70461406
137negative regulation of potassium ion transmembrane transporter activity (GO:1901017)2.70354065
138coenzyme catabolic process (GO:0009109)2.70197078
139ethanol oxidation (GO:0006069)2.69971428
140drug catabolic process (GO:0042737)2.68850558
141bile acid and bile salt transport (GO:0015721)2.68457676
142DNA replication initiation (GO:0006270)2.67945304
143glucocorticoid biosynthetic process (GO:0006704)2.67507781
144double-strand break repair via nonhomologous end joining (GO:0006303)2.67466013
145non-recombinational repair (GO:0000726)2.67466013
146midgut development (GO:0007494)2.67099766
147chromosome condensation (GO:0030261)2.65625042
148cellular amino acid catabolic process (GO:0009063)2.65252514
1494-hydroxyproline metabolic process (GO:0019471)2.65097474
150fatty acid catabolic process (GO:0009062)2.64996619
151carnitine transmembrane transport (GO:1902603)2.64948054
152protein localization to chromosome, centromeric region (GO:0071459)2.64236371
153regulation of cholesterol homeostasis (GO:2000188)2.63359642
154positive regulation of glycogen biosynthetic process (GO:0045725)2.63246121
155regulation of DNA endoreduplication (GO:0032875)2.62906291
156IMP biosynthetic process (GO:0006188)2.61532045
157very-low-density lipoprotein particle assembly (GO:0034379)2.61418640
158negative regulation of sterol transport (GO:0032372)2.60312282
159negative regulation of cholesterol transport (GO:0032375)2.60312282
160regulation of necroptotic process (GO:0060544)2.58476154
161response to muscle activity (GO:0014850)2.57536341
162cell-substrate junction assembly (GO:0007044)2.56319111
163DNA conformation change (GO:0071103)2.55653344
164positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.55389273
165DNA strand elongation involved in DNA replication (GO:0006271)2.55182101
166RNA stabilization (GO:0043489)2.54502800
167mRNA stabilization (GO:0048255)2.54502800
168DNA packaging (GO:0006323)2.51041306
169pinocytosis (GO:0006907)2.50214466
170negative regulation of potassium ion transmembrane transport (GO:1901380)2.49121136
171polysaccharide catabolic process (GO:0000272)2.48293729
172DNA strand elongation (GO:0022616)2.44716199
173peptidyl-lysine dimethylation (GO:0018027)2.44113305
174NLS-bearing protein import into nucleus (GO:0006607)2.43752158
175nuclear envelope organization (GO:0006998)2.42333024
176regulation of relaxation of muscle (GO:1901077)2.40902560
177adherens junction assembly (GO:0034333)2.40859735
178glutamine metabolic process (GO:0006541)2.40386765
179spliceosomal tri-snRNP complex assembly (GO:0000244)2.40131795
180response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.40035795
181mitochondrial DNA metabolic process (GO:0032042)2.38242036
182desmosome organization (GO:0002934)2.38021269
183ribosome biogenesis (GO:0042254)2.36922454
184hepatocyte differentiation (GO:0070365)2.35539724
185L-alpha-amino acid transmembrane transport (GO:1902475)2.35246846
186regulation of immune response to tumor cell (GO:0002837)2.34514581
187regulation of response to tumor cell (GO:0002834)2.34514581
188positive regulation of response to tumor cell (GO:0002836)2.34514581
189positive regulation of immune response to tumor cell (GO:0002839)2.34514581
190definitive hemopoiesis (GO:0060216)2.33693405
191positive regulation of myotube differentiation (GO:0010831)2.33366616
192NADH metabolic process (GO:0006734)2.33051126
193protein hydroxylation (GO:0018126)2.31921138
194folic acid metabolic process (GO:0046655)2.31697283
195actomyosin structure organization (GO:0031032)2.30294318
196cytokine production involved in immune response (GO:0002367)2.28828388

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.53984895
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.02087168
3RXR_22158963_ChIP-Seq_LIVER_Mouse4.44278139
4LXR_22158963_ChIP-Seq_LIVER_Mouse3.89066824
5EGR1_23403033_ChIP-Seq_LIVER_Mouse3.81177845
6PPARA_22158963_ChIP-Seq_LIVER_Mouse3.70645024
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.54961746
8ZNF263_19887448_ChIP-Seq_K562_Human3.27373377
9EGR1_19374776_ChIP-ChIP_THP-1_Human3.24786023
10NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.22404713
11PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.76477778
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.63616347
13FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.56242702
14MYC_22102868_ChIP-Seq_BL_Human2.54299457
15AR_21909140_ChIP-Seq_LNCAP_Human2.52651774
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.40868083
17KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.34819863
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.27305885
19GATA1_22025678_ChIP-Seq_K562_Human2.26952716
20MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.10113789
21BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.07546942
22FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.07135766
23E2F4_17652178_ChIP-ChIP_JURKAT_Human2.01829330
24* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.99457982
25FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96900931
26E2F1_21310950_ChIP-Seq_MCF-7_Human1.88466703
27MYC_19079543_ChIP-ChIP_MESCs_Mouse1.87231957
28SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.86091671
29RBPJ_22232070_ChIP-Seq_NCS_Mouse1.83896966
30PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.82361948
31MYCN_18555785_ChIP-Seq_MESCs_Mouse1.76935714
32TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.76846625
33MYC_19030024_ChIP-ChIP_MESCs_Mouse1.75966393
34PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75545653
35KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.73463318
36GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70088410
37* FOXA2_19822575_ChIP-Seq_HepG2_Human1.68810185
38GBX2_23144817_ChIP-Seq_PC3_Human1.67819684
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.66493136
40PCGF2_27294783_Chip-Seq_NPCs_Mouse1.66396187
41ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.66329144
42TFEB_21752829_ChIP-Seq_HELA_Human1.65469308
43* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61348303
44* NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.60653778
45CDX2_19796622_ChIP-Seq_MESCs_Mouse1.60143366
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.59794281
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.59076295
48ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58080882
49NELFA_20434984_ChIP-Seq_ESCs_Mouse1.57471479
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.56551790
51TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.50469567
52ESR1_21235772_ChIP-Seq_MCF-7_Human1.49419879
53STAT3_1855785_ChIP-Seq_MESCs_Mouse1.48147112
54PIAS1_25552417_ChIP-Seq_VCAP_Human1.47900999
55TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.46687853
56TRIM28_21343339_ChIP-Seq_HEK293_Human1.45478254
57CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.45453487
58BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.44679280
59EP300_21415370_ChIP-Seq_HL-1_Mouse1.44605744
60CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.44591153
61* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.44064633
62CLOCK_20551151_ChIP-Seq_293T_Human1.43672052
63BRD4_27068464_Chip-Seq_AML-cells_Mouse1.43061101
64ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.41511703
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.40834229
66KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.40396825
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.40379083
68NFE2_27457419_Chip-Seq_LIVER_Mouse1.38752709
69HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.38425822
70TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38182961
71* MYC_18358816_ChIP-ChIP_MESCs_Mouse1.38004917
72ZNF217_24962896_ChIP-Seq_MCF-7_Human1.37990317
73SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36805602
74CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.34650953
75FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.34447502
76SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.34271481
77KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.31991797
78TCF7_22412390_ChIP-Seq_EML_Mouse1.30697628
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30281494
80EZH2_27294783_Chip-Seq_NPCs_Mouse1.30052918
81CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.29404193
82* DCP1A_22483619_ChIP-Seq_HELA_Human1.27613075
83RARG_19884340_ChIP-ChIP_MEFs_Mouse1.27602971
84NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.24336227
85VDR_21846776_ChIP-Seq_THP-1_Human1.24231020
86YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.23528224
87ATF3_27146783_Chip-Seq_COLON_Human1.23208169
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.23156745
89ESR1_20079471_ChIP-ChIP_T-47D_Human1.21476311
90CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.21384695
91SALL1_21062744_ChIP-ChIP_HESCs_Human1.21051223
92TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.20331208
93BCAT_22108803_ChIP-Seq_LS180_Human1.20130671
94* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.19676994
95CHD1_26751641_Chip-Seq_LNCaP_Human1.18979037
96CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18947154
97P300_27058665_Chip-Seq_ZR-75-30cells_Human1.18829118
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.18651420
99TP53_16413492_ChIP-PET_HCT116_Human1.18397177
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.17461219
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.17461219
102PPAR_26484153_Chip-Seq_NCI-H1993_Human1.16809907
103CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.16781924
104NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.16339924
105ERG_20887958_ChIP-Seq_HPC-7_Mouse1.16229209
106EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.15059539
107HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.14485518
108CJUN_26792858_Chip-Seq_BT549_Human1.14128058
109* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.13448749
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.13236159
111ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12579870
112RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12339482
113PCGF2_27294783_Chip-Seq_ESCs_Mouse1.11587005
114SOX9_24532713_ChIP-Seq_HFSC_Mouse1.10615153
115* HNF4A_19822575_ChIP-Seq_HepG2_Human1.10134356
116BRD4_25478319_ChIP-Seq_HGPS_Human1.09848437
117POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.08207285
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.07764921
119NRF2_20460467_ChIP-Seq_MEFs_Mouse1.07764921
120Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.06619003
121CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.06003636
122* UBF1/2_26484160_Chip-Seq_HMECs_Human1.05750694
123SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.05483185
124TP53_18474530_ChIP-ChIP_U2OS_Human1.04298135
125SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.04100576
126ISL1_27105846_Chip-Seq_CPCs_Mouse1.03453013
127NCOR1_26117541_ChIP-Seq_K562_Human1.02756351
128FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.01862611
129DROSHA_22980978_ChIP-Seq_HELA_Human1.01456215
130CTNNB1_20460455_ChIP-Seq_HCT116_Human1.01351120
131TP63_17297297_ChIP-ChIP_HaCaT_Human1.01020942
132WT1_19549856_ChIP-ChIP_CCG9911_Human1.00552931
133ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.00509152
134TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00455366
135OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99870045
136KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.99739719
137EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98158745
138STAT3_23295773_ChIP-Seq_U87_Human0.97632164
139* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96583893
140TCF4_18268006_ChIP-ChIP_LS174T_Human0.96356148
141TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96095750
142SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.95851814
143AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.94040157
144PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93911026
145PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.93905200
146DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.93138476
147FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92969812
148GATA2_22383799_ChIP-Seq_G1ME_Mouse0.92934764
149GATA4_25053715_ChIP-Seq_YYC3_Human0.92430427
150GATA2_21666600_ChIP-Seq_HMVEC_Human0.92266291
151MAF_26560356_Chip-Seq_TH1_Human0.92084151
152ESR2_21235772_ChIP-Seq_MCF-7_Human0.91682650
153PU_27001747_Chip-Seq_BMDM_Mouse0.91655328
154CRX_20693478_ChIP-Seq_RETINA_Mouse0.91140296
155E2F1_18555785_ChIP-Seq_MESCs_Mouse0.91011619
156* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.90933300
157RUNX1_22412390_ChIP-Seq_EML_Mouse0.90045214
158ARNT_22903824_ChIP-Seq_MCF-7_Human0.89856134
159TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.89579977
160NFIB_24661679_ChIP-Seq_LUNG_Mouse0.89547698
161PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.89444043
162P53_22387025_ChIP-Seq_ESCs_Mouse0.89329693
163FOXM1_26456572_ChIP-Seq_MCF-7_Human0.88763902
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.88721716
165IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.88005612
166MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.87950887
167POU3F2_20337985_ChIP-ChIP_501MEL_Human0.87782359
168* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87365954
169RACK7_27058665_Chip-Seq_MCF-7_Human0.87186147
170AHR_22903824_ChIP-Seq_MCF-7_Human0.86972664
171SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.86884691
172SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.86867701
173SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.86867701
174NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86646807
175FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.86011443
176* TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.85904432
177SMAD4_21799915_ChIP-Seq_A2780_Human0.84233881
178HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.83627755
179NANOG_18555785_Chip-Seq_ESCs_Mouse0.82911962
180ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82188649
181PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.82066479
182FOXO3_23340844_ChIP-Seq_DLD1_Human0.81739586
183* TCF4_23295773_ChIP-Seq_U87_Human0.81296607
184STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81217689

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.31816720
2MP0005360_urolithiasis4.75790695
3MP0005365_abnormal_bile_salt4.42917495
4MP0005085_abnormal_gallbladder_physiolo4.18777225
5MP0003252_abnormal_bile_duct3.70316150
6MP0002877_abnormal_melanocyte_morpholog3.16840270
7MP0003705_abnormal_hypodermis_morpholog3.05946988
8MP0008438_abnormal_cutaneous_collagen3.02991659
9MP0004233_abnormal_muscle_weight2.86971384
10MP0008057_abnormal_DNA_replication2.67690768
11MP0003195_calcinosis2.62075042
12MP0003646_muscle_fatigue2.61354311
13MP0000569_abnormal_digit_pigmentation2.56426523
14MP0010352_gastrointestinal_tract_polyps2.55508269
15MP0010329_abnormal_lipoprotein_level2.53746187
16MP0005083_abnormal_biliary_tract2.45066688
17MP0008875_abnormal_xenobiotic_pharmacok2.40943692
18MP0005670_abnormal_white_adipose2.25411169
19MP0010234_abnormal_vibrissa_follicle2.07533370
20MP0002009_preneoplasia2.07277283
21MP0003868_abnormal_feces_composition2.04844820
22MP0010094_abnormal_chromosome_stability1.91309604
23MP0003111_abnormal_nucleus_morphology1.90664023
24MP0003950_abnormal_plasma_membrane1.90341908
25MP0005275_abnormal_skin_tensile1.85479073
26MP0000747_muscle_weakness1.82029533
27MP0004957_abnormal_blastocyst_morpholog1.81931542
28MP0001666_abnormal_nutrient_absorption1.81282757
29* MP0004808_abnormal_hematopoietic_stem1.77797947
30MP0004130_abnormal_muscle_cell1.76201570
31MP0002396_abnormal_hematopoietic_system1.71078045
32MP0003693_abnormal_embryo_hatching1.70004934
33MP0009384_cardiac_valve_regurgitation1.67088456
34MP0002837_dystrophic_cardiac_calcinosis1.61518012
35MP0002106_abnormal_muscle_physiology1.57192148
36MP0010368_abnormal_lymphatic_system1.54685760
37MP0005666_abnormal_adipose_tissue1.53721917
38MP0005503_abnormal_tendon_morphology1.51633249
39MP0004019_abnormal_vitamin_homeostasis1.51188252
40MP0000013_abnormal_adipose_tissue1.49282796
41MP0000609_abnormal_liver_physiology1.49125755
42MP0005623_abnormal_meninges_morphology1.44390818
43MP0000750_abnormal_muscle_regeneration1.43415484
44MP0003279_aneurysm1.41571215
45MP0002118_abnormal_lipid_homeostasis1.40920617
46* MP0003077_abnormal_cell_cycle1.40169941
47MP0001730_embryonic_growth_arrest1.39587766
48MP0002332_abnormal_exercise_endurance1.38288322
49MP0009697_abnormal_copulation1.36567214
50MP0002060_abnormal_skin_morphology1.35703241
51MP0005409_darkened_coat_color1.34305408
52MP0004272_abnormal_basement_membrane1.32962821
53MP0000751_myopathy1.32026813
54MP0005647_abnormal_sex_gland1.30689894
55MP0005369_muscle_phenotype1.30658713
56MP0000427_abnormal_hair_cycle1.29645406
57MP0000749_muscle_degeneration1.27559698
58MP0002138_abnormal_hepatobiliary_system1.24370740
59MP0003763_abnormal_thymus_physiology1.23269981
60MP0002928_abnormal_bile_duct1.22966893
61MP0004215_abnormal_myocardial_fiber1.22834438
62MP0005220_abnormal_exocrine_pancreas1.21296903
63MP0005332_abnormal_amino_acid1.21220780
64MP0003984_embryonic_growth_retardation1.18760128
65MP0001661_extended_life_span1.18708363
66MP0003453_abnormal_keratinocyte_physiol1.18443378
67MP0003221_abnormal_cardiomyocyte_apopto1.17699435
68MP0005451_abnormal_body_composition1.17576120
69MP0003300_gastrointestinal_ulcer1.17487264
70MP0004147_increased_porphyrin_level1.16071750
71MP0003566_abnormal_cell_adhesion1.15997253
72MP0000350_abnormal_cell_proliferation1.15098704
73MP0002088_abnormal_embryonic_growth/wei1.14875563
74MP0001672_abnormal_embryogenesis/_devel1.13776494
75MP0005380_embryogenesis_phenotype1.13776494
76MP0002971_abnormal_brown_adipose1.13331999
77MP0002796_impaired_skin_barrier1.13126505
78MP0003283_abnormal_digestive_organ1.13071124
79MP0002086_abnormal_extraembryonic_tissu1.10453949
80MP0008007_abnormal_cellular_replicative1.09972061
81MP0004185_abnormal_adipocyte_glucose1.08613708
82MP0002896_abnormal_bone_mineralization1.08539125
83MP0004084_abnormal_cardiac_muscle1.07524121
84MP0005375_adipose_tissue_phenotype1.05315378
85MP0005257_abnormal_intraocular_pressure1.04869478
86MP0005334_abnormal_fat_pad1.04570739
87MP0001348_abnormal_lacrimal_gland1.03685205
88MP0005501_abnormal_skin_physiology1.03069861
89MP0005319_abnormal_enzyme/_coenzyme1.01976591
90MP0002166_altered_tumor_susceptibility1.01572048
91MP0000579_abnormal_nail_morphology1.00546490
92MP0000767_abnormal_smooth_muscle0.99606964
93* MP0002080_prenatal_lethality0.99319915
94MP0008775_abnormal_heart_ventricle0.98626143
95MP0002108_abnormal_muscle_morphology0.98421149
96MP0001697_abnormal_embryo_size0.98259395
97MP0000383_abnormal_hair_follicle0.97120657
98MP0003045_fibrosis0.95854564
99MP0004087_abnormal_muscle_fiber0.95294307
100MP0002269_muscular_atrophy0.94688961
101MP0002168_other_aberrant_phenotype0.94622119
102MP0003806_abnormal_nucleotide_metabolis0.94333104
103MP0010630_abnormal_cardiac_muscle0.93275548
104MP0003191_abnormal_cellular_cholesterol0.93239824
105MP0005330_cardiomyopathy0.90773354
106MP0001958_emphysema0.90403630
107MP0005621_abnormal_cell_physiology0.89826438
108MP0009672_abnormal_birth_weight0.89691630
109MP0009840_abnormal_foam_cell0.88368149
110MP0003656_abnormal_erythrocyte_physiolo0.87986132
111MP0002972_abnormal_cardiac_muscle0.87567982
112MP0000733_abnormal_muscle_development0.86527658
113MP0002078_abnormal_glucose_homeostasis0.83965247
114MP0006054_spinal_hemorrhage0.83695489
115MP0009764_decreased_sensitivity_to0.83618190
116MP0002697_abnormal_eye_size0.82860691
117MP0001243_abnormal_dermal_layer0.82388169
118MP0005248_abnormal_Harderian_gland0.80691021
119MP0000428_abnormal_craniofacial_morphol0.80682105
120MP0002254_reproductive_system_inflammat0.80171046
121MP0008932_abnormal_embryonic_tissue0.79929606
122MP0005023_abnormal_wound_healing0.79861675
123MP0000003_abnormal_adipose_tissue0.76340988
124MP0001216_abnormal_epidermal_layer0.76167388
125MP0004197_abnormal_fetal_growth/weight/0.76069823
126MP0000313_abnormal_cell_death0.76046921
127MP0002084_abnormal_developmental_patter0.74948807
128MP0010678_abnormal_skin_adnexa0.74622919
129MP0005076_abnormal_cell_differentiation0.74446928
130MP0004484_altered_response_of0.74271151
131MP0009643_abnormal_urine_homeostasis0.74063422
132MP0002128_abnormal_blood_circulation0.73950763
133MP0001849_ear_inflammation0.73506145
134* MP0008058_abnormal_DNA_repair0.73348127
135MP0004036_abnormal_muscle_relaxation0.72749880
136MP0002006_tumorigenesis0.72575339
137MP0004145_abnormal_muscle_electrophysio0.71516654
138MP0005620_abnormal_muscle_contractility0.71267361
139MP0000598_abnormal_liver_morphology0.70499644
140MP0002234_abnormal_pharynx_morphology0.69764696
141MP0003828_pulmonary_edema0.69537310
142MP0000759_abnormal_skeletal_muscle0.69258921
143MP0009115_abnormal_fat_cell0.69073229
144MP0005384_cellular_phenotype0.68659172
145MP0005187_abnormal_penis_morphology0.68252650
146MP0009763_increased_sensitivity_to0.67144003
147MP0001544_abnormal_cardiovascular_syste0.67142740
148MP0005385_cardiovascular_system_phenoty0.67142740
149MP0006138_congestive_heart_failure0.65027881
150MP0003011_delayed_dark_adaptation0.64182231
151MP0003115_abnormal_respiratory_system0.63411934
152MP0003941_abnormal_skin_development0.63101699
153MP0010307_abnormal_tumor_latency0.62995499
154MP0003091_abnormal_cell_migration0.61617952
155MP0001915_intracranial_hemorrhage0.60370302
156MP0009703_decreased_birth_body0.60342050
157MP0000266_abnormal_heart_morphology0.58758063

Predicted human phenotypes

RankGene SetZ-score
1Nemaline bodies (HP:0003798)6.21729206
2Muscle fiber inclusion bodies (HP:0100299)6.11564048
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)6.04016761
4Exercise-induced myalgia (HP:0003738)4.65765615
5Deep venous thrombosis (HP:0002625)4.50741662
6Intrahepatic cholestasis (HP:0001406)4.13535768
7Prolonged partial thromboplastin time (HP:0003645)4.07555104
8Exercise-induced muscle cramps (HP:0003710)3.83117193
9Xanthomatosis (HP:0000991)3.71500661
10Hypoglycemic coma (HP:0001325)3.66839427
11Hypoalphalipoproteinemia (HP:0003233)3.62695414
12Centrally nucleated skeletal muscle fibers (HP:0003687)3.52974639
13Abnormality of monocarboxylic acid metabolism (HP:0010996)3.42278127
14Hyperlipoproteinemia (HP:0010980)3.38277548
15Joint hemorrhage (HP:0005261)3.29389600
16Abnormality of skeletal muscle fiber size (HP:0012084)3.25837831
17Abnormality of the intrinsic pathway (HP:0010989)3.20782193
18Rhabdomyolysis (HP:0003201)3.20323170
19EMG: myopathic abnormalities (HP:0003458)3.14599871
20Ketosis (HP:0001946)3.13062966
21Distal arthrogryposis (HP:0005684)3.11316891
22Epidermoid cyst (HP:0200040)3.10380813
23Progressive muscle weakness (HP:0003323)3.10253405
24Abnormality of the common coagulation pathway (HP:0010990)3.10153216
25Calcaneovalgus deformity (HP:0001848)3.04189649
26Abnormality of the left ventricular outflow tract (HP:0011103)3.02896479
27Subaortic stenosis (HP:0001682)3.02896479
28Hypolipoproteinemia (HP:0010981)3.02153734
29Complement deficiency (HP:0004431)3.00420434
30Round ear (HP:0100830)3.00029797
31Myopathic facies (HP:0002058)2.99650848
32Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.97925434
33Protrusio acetabuli (HP:0003179)2.96575237
34Abnormality of aromatic amino acid family metabolism (HP:0004338)2.82540703
35Increased variability in muscle fiber diameter (HP:0003557)2.82319738
36Neck muscle weakness (HP:0000467)2.82250658
37Hepatocellular carcinoma (HP:0001402)2.81509180
38Hyperinsulinemic hypoglycemia (HP:0000825)2.81100458
39Increased connective tissue (HP:0009025)2.80037045
40Abnormality of the calcaneus (HP:0008364)2.78144913
41Distal lower limb amyotrophy (HP:0008944)2.77366868
42Ulnar deviation of the wrist (HP:0003049)2.76626433
43Myocardial infarction (HP:0001658)2.75592571
44Hypobetalipoproteinemia (HP:0003563)2.70421298
45Deformed tarsal bones (HP:0008119)2.70272752
46Ketoacidosis (HP:0001993)2.67629304
47Rimmed vacuoles (HP:0003805)2.67553041
48Hypoglycemic seizures (HP:0002173)2.63107319
49Poikilocytosis (HP:0004447)2.62425821
50Muscle hypertrophy of the lower extremities (HP:0008968)2.62181101
51Osteolytic defects of the phalanges of the hand (HP:0009771)2.61497036
52Osteolytic defects of the hand bones (HP:0009699)2.61497036
53Abnormality of glutamine family amino acid metabolism (HP:0010902)2.60601098
54Muscle fiber splitting (HP:0003555)2.56284230
55Renal cortical cysts (HP:0000803)2.55883710
56Mildly elevated creatine phosphokinase (HP:0008180)2.55483415
57Premature rupture of membranes (HP:0001788)2.54043931
58Dysmetric saccades (HP:0000641)2.52937231
59Abnormality of sulfur amino acid metabolism (HP:0004339)2.51736206
60Distal lower limb muscle weakness (HP:0009053)2.46845075
61Abnormality of pyrimidine metabolism (HP:0004353)2.45488063
62Achilles tendon contracture (HP:0001771)2.45373565
63Abnormality of the calf musculature (HP:0001430)2.44714882
64Type 1 muscle fiber predominance (HP:0003803)2.44502890
65Right ventricular cardiomyopathy (HP:0011663)2.43297731
66Mesomelia (HP:0003027)2.43079887
67Spinal rigidity (HP:0003306)2.40036713
68Hyperammonemia (HP:0001987)2.39002784
69Calf muscle hypertrophy (HP:0008981)2.36009603
70Cardiovascular calcification (HP:0011915)2.34637414
71Hyperglycemia (HP:0003074)2.31054190
72Broad metatarsal (HP:0001783)2.30526722
73Hypercholesterolemia (HP:0003124)2.29651807
74Renovascular hypertension (HP:0100817)2.29452959
75Turricephaly (HP:0000262)2.25634332
76Shoulder girdle muscle weakness (HP:0003547)2.25180430
77Conjugated hyperbilirubinemia (HP:0002908)2.24437145
78Enlarged kidneys (HP:0000105)2.24185212
79Skin nodule (HP:0200036)2.23695513
80Mitral stenosis (HP:0001718)2.22688422
81Difficulty running (HP:0009046)2.22132523
82Reticulocytosis (HP:0001923)2.21464025
83Abnormality of aspartate family amino acid metabolism (HP:0010899)2.19634324
84Abnormality of the Achilles tendon (HP:0005109)2.18709991
85Progressive external ophthalmoplegia (HP:0000590)2.16808643
86Lymphangioma (HP:0100764)2.16352828
87Acanthocytosis (HP:0001927)2.16192513
88Elbow flexion contracture (HP:0002987)2.15997497
89Ragged-red muscle fibers (HP:0003200)2.15285087
90Abnormality of methionine metabolism (HP:0010901)2.14176074
91Ankyloglossia (HP:0010296)2.14003779
92Hyperbilirubinemia (HP:0002904)2.13127525
93Asymmetric septal hypertrophy (HP:0001670)2.12685614
94Scapular winging (HP:0003691)2.11282921
95Limb-girdle muscle weakness (HP:0003325)2.11266582
96Difficulty climbing stairs (HP:0003551)2.10647665
97Pelvic girdle muscle weakness (HP:0003749)2.10592725
98Lower limb amyotrophy (HP:0007210)2.10227527
99Selective tooth agenesis (HP:0001592)2.09332797
100Abnormality of nucleobase metabolism (HP:0010932)2.09326421
101Aneurysm (HP:0002617)2.09255261
102Chorioretinal atrophy (HP:0000533)2.08863812
103Aortic aneurysm (HP:0004942)2.07859805
104Spastic diplegia (HP:0001264)2.07390882
105Upper limb muscle weakness (HP:0003484)2.07184034
106Slender build (HP:0001533)2.06736486
107Vascular calcification (HP:0004934)2.05354077
108Ventricular tachycardia (HP:0004756)2.03749094
109Hyperglycinuria (HP:0003108)2.02106962
110Hypoplastic ischia (HP:0003175)2.01628305
111Cerebral aneurysm (HP:0004944)2.01231292
112Long toe (HP:0010511)2.00776754
113Abnormality of fatty-acid metabolism (HP:0004359)2.00716988
114Fragile skin (HP:0001030)2.00203386
115Hyporeflexia of lower limbs (HP:0002600)1.99973900
116Deep philtrum (HP:0002002)1.99666246
117Abnormality of complement system (HP:0005339)1.99521626
118Bundle branch block (HP:0011710)1.98351678
119Lipoatrophy (HP:0100578)1.96555407
120Areflexia of lower limbs (HP:0002522)1.96396060
121Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.95888662
122Fatigue (HP:0012378)1.95156677
123Pigmentary retinal degeneration (HP:0001146)1.93915920
124Abnormality of oral frenula (HP:0000190)1.92795543
125Syringomyelia (HP:0003396)1.92240856
126Spinal cord lesions (HP:0100561)1.92240856
127Generalized amyotrophy (HP:0003700)1.91751284
128Hypochromic microcytic anemia (HP:0004840)1.91505536
129Abnormality of purine metabolism (HP:0004352)1.91245601
130Hydroxyprolinuria (HP:0003080)1.91138690
131Abnormality of proline metabolism (HP:0010907)1.91138690
132Myoglobinuria (HP:0002913)1.90929237
133Abnormality of the ischium (HP:0003174)1.90559153
134Microvesicular hepatic steatosis (HP:0001414)1.90506096
135Congenital stationary night blindness (HP:0007642)1.90424229
136Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90269281
137Abnormality of glycine metabolism (HP:0010895)1.89353876
138Abnormality of serine family amino acid metabolism (HP:0010894)1.89353876
139Atrophic scars (HP:0001075)1.89081626
140Metatarsus adductus (HP:0001840)1.87767797
141Abnormality of the renal cortex (HP:0011035)1.87109036
142Sparse lateral eyebrow (HP:0005338)1.86792249
143Ankle contracture (HP:0006466)1.85994765
144Entropion (HP:0000621)1.83958255
145Muscle stiffness (HP:0003552)1.83542994
146Cholelithiasis (HP:0001081)1.83071638
147Reduced subcutaneous adipose tissue (HP:0003758)1.82337488
148Fat malabsorption (HP:0002630)1.81938984
149Generalized muscle weakness (HP:0003324)1.81249606
150Elfin facies (HP:0004428)1.80893608
151Aortic dissection (HP:0002647)1.80390590
152Ectopia lentis (HP:0001083)1.79422637
153Mitral valve prolapse (HP:0001634)1.78940789
154Limb-girdle muscle atrophy (HP:0003797)1.78675130
155Esophageal varix (HP:0002040)1.78549709
156Asymmetry of the thorax (HP:0001555)1.77190129
157Dilated cardiomyopathy (HP:0001644)1.76480799
158Vertebral compression fractures (HP:0002953)1.75939465
159Sudden death (HP:0001699)1.75086246
160Symptomatic seizures (HP:0011145)1.74948835
161Abnormality of serum amino acid levels (HP:0003112)1.74087846
162Flat acetabular roof (HP:0003180)1.73913790
163Bell-shaped thorax (HP:0001591)1.73550705
164Hyperglycinemia (HP:0002154)1.73271851
165Abnormal gallbladder morphology (HP:0012437)1.72483015
166Bladder diverticulum (HP:0000015)1.71954032
167Enlarged penis (HP:0000040)1.69662514
168Trismus (HP:0000211)1.68955228
169Osteomalacia (HP:0002749)1.68822840
170Dislocated radial head (HP:0003083)1.68608847
171Subacute progressive viral hepatitis (HP:0006572)1.68072904
172Abnormality of the musculature of the pelvis (HP:0001469)1.67681494
173Abnormality of the hip-girdle musculature (HP:0001445)1.67681494
174Wormian bones (HP:0002645)1.66487281
175Hyperkalemia (HP:0002153)1.65281593
176Hyperacusis (HP:0010780)1.64449325
177Acute myeloid leukemia (HP:0004808)1.60976169
178Malignant hyperthermia (HP:0002047)1.60847931
179Abnormality of the tricuspid valve (HP:0001702)1.59107106
180Natal tooth (HP:0000695)1.55755620
181Advanced eruption of teeth (HP:0006288)1.54641200
182Abnormality of the salivary glands (HP:0010286)1.54467554
183Breech presentation (HP:0001623)1.53915974
184Short nail (HP:0001799)1.52389518
185Deviation of the thumb (HP:0009603)1.52143438
186Heterotopia (HP:0002282)1.51687452
187Bulbar palsy (HP:0001283)1.51663189

Predicted kinase interactions (KEA)

RankGene SetZ-score
1LATS13.76599694
2SIK13.72850067
3INSRR3.68104362
4TTN3.03177982
5PKN22.82300968
6PBK2.81156581
7CAMK1D2.76230216
8TRIB32.57067520
9PRPF4B2.16338696
10FRK2.13445694
11CAMK1G2.12999803
12NEK12.00765290
13SMG11.97433852
14CDK121.93171988
15PIK3CG1.91958059
16PDGFRA1.74994653
17FLT31.74334681
18EIF2AK21.73912385
19RPS6KB21.69058990
20PTK61.67768253
21BCKDK1.67232147
22NEK91.62583649
23FGFR41.62226900
24TSSK61.60842902
25TAOK31.60713292
26ERN11.60483517
27RIPK11.59596791
28ZAK1.57161102
29OBSCN1.57021914
30EIF2AK11.46196226
31JAK11.43581552
32PRKAA21.40917001
33STK31.40832775
34CDC71.31084524
35MAP3K71.31066714
36STK241.28240608
37DDR21.27597893
38CDK61.21067050
39FER1.19626265
40MTOR1.19045099
41BRSK21.18630494
42LATS21.16992772
43MST1R1.16257238
44PIK3CA1.16059554
45GRK11.14923127
46EIF2AK31.14763807
47MAP3K131.10531752
48AKT31.10174436
49STK38L1.09554459
50TGFBR21.08143456
51NME21.08004612
52NUAK11.07857746
53PTK21.07739330
54PRKAA11.05193046
55PDK41.05118159
56PDK31.05118159
57BRD41.01930909
58MAP3K140.98997987
59DMPK0.95835558
60ERBB20.92626262
61MAP3K80.89974679
62MKNK10.89116836
63AKT20.88015129
64FGFR20.85696462
65EPHA30.85301959
66PAK20.85170900
67SRPK10.84255917
68SGK30.82777485
69LMTK20.82266480
70MAP3K100.81428342
71KSR20.81215616
72MAPK110.80790320
73FGFR10.76110078
74PDGFRB0.74468689
75CDK80.74136941
76BRAF0.72920189
77CHEK10.72489816
78RPS6KA40.70740914
79SIK20.70613354
80FGFR30.69711213
81DYRK1B0.68421559
82SGK20.68326689
83MAP3K20.67746195
84MELK0.67584438
85CDK70.67356152
86RPS6KB10.67000658
87PNCK0.66600025
88ERBB40.65746679
89ICK0.65014921
90CDC42BPA0.64659534
91MAP3K10.63077775
92TYK20.62787445
93EEF2K0.62527878
94PAK40.60636148
95PAK30.60478291
96NEK20.60130862
97RAF10.59927568
98MAP3K60.59650652
99STK40.59419422
100MET0.59407792
101MOS0.59124309
102CDK90.58466241
103AURKB0.56110748
104SGK10.55863011
105TAF10.54743682
106CLK10.52529200
107CDK40.51895147
108TTK0.51871186
109TIE10.50857030
110CHEK20.50329053
111MAP2K30.50206685
112STK380.49790856
113CAMK40.49056588
114WNK10.49039432
115RET0.48760036
116JAK20.48440849
117PLK10.47356619
118MAPK120.46008172
119CHUK0.45059774
120SCYL20.44923689
121TAOK20.44032212
122IRAK30.43905994
123BMX0.43452946
124YES10.42956676
125MAP2K20.41883485
126AKT10.41868987
127EPHA20.41670528
128WEE10.41483098
129DAPK20.41368791
130EPHB20.40799518
131TRPM70.39870704
132NLK0.39685876
133PHKG10.39408452
134PHKG20.39408452
135MAP3K30.39355111
136MAPK70.39135547
137MAP2K10.39019582
138STK100.38950486
139PDK20.38264667
140PRKACG0.37564727
141ROCK10.37326655
142MAP3K50.36880419
143ZAP700.36823538
144ATR0.36420568
145BUB10.36410166
146TGFBR10.35540194
147RPS6KC10.34993644
148RPS6KL10.34993644
149MAPK100.34704714
150RPS6KA10.34462112
151MAP2K40.33428561

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.28998717
2Fatty acid degradation_Homo sapiens_hsa000713.03474728
3Tryptophan metabolism_Homo sapiens_hsa003802.71891614
4Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.65713519
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.47941779
6Nitrogen metabolism_Homo sapiens_hsa009102.47803768
7DNA replication_Homo sapiens_hsa030302.42966769
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.37726717
9Complement and coagulation cascades_Homo sapiens_hsa046102.37654972
10Arginine biosynthesis_Homo sapiens_hsa002202.32919395
11Propanoate metabolism_Homo sapiens_hsa006402.32067441
12Lysine degradation_Homo sapiens_hsa003102.24936328
13Fatty acid metabolism_Homo sapiens_hsa012122.24093003
14PPAR signaling pathway_Homo sapiens_hsa033202.07962885
15Thyroid cancer_Homo sapiens_hsa052162.06944622
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.93442768
17Non-homologous end-joining_Homo sapiens_hsa034501.91734106
18Pentose phosphate pathway_Homo sapiens_hsa000301.88544686
19Caffeine metabolism_Homo sapiens_hsa002321.88204833
20Butanoate metabolism_Homo sapiens_hsa006501.87912235
21ABC transporters_Homo sapiens_hsa020101.87390731
22beta-Alanine metabolism_Homo sapiens_hsa004101.81673837
23Cell cycle_Homo sapiens_hsa041101.80802214
24Pentose and glucuronate interconversions_Homo sapiens_hsa000401.79088532
25Steroid hormone biosynthesis_Homo sapiens_hsa001401.74329683
26Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.72151405
27Selenocompound metabolism_Homo sapiens_hsa004501.67499080
28Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.64793231
29Maturity onset diabetes of the young_Homo sapiens_hsa049501.64099695
30Peroxisome_Homo sapiens_hsa041461.60420853
31RNA transport_Homo sapiens_hsa030131.59825532
32Starch and sucrose metabolism_Homo sapiens_hsa005001.59639867
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53177927
34mRNA surveillance pathway_Homo sapiens_hsa030151.51620201
35Non-small cell lung cancer_Homo sapiens_hsa052231.50917405
36Mismatch repair_Homo sapiens_hsa034301.44630448
37Pancreatic cancer_Homo sapiens_hsa052121.44157620
38Bile secretion_Homo sapiens_hsa049761.40550728
39Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.40329511
40Retinol metabolism_Homo sapiens_hsa008301.39077944
41Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.35127392
42Acute myeloid leukemia_Homo sapiens_hsa052211.34581410
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.33467158
44Endometrial cancer_Homo sapiens_hsa052131.21614704
45Histidine metabolism_Homo sapiens_hsa003401.21472836
46Fatty acid biosynthesis_Homo sapiens_hsa000611.17595558
47Chemical carcinogenesis_Homo sapiens_hsa052041.16083555
48* Nucleotide excision repair_Homo sapiens_hsa034201.15607923
49Phenylalanine metabolism_Homo sapiens_hsa003601.15010224
50Viral carcinogenesis_Homo sapiens_hsa052031.14284530
51One carbon pool by folate_Homo sapiens_hsa006701.12156686
52Pyruvate metabolism_Homo sapiens_hsa006201.10532609
53Staphylococcus aureus infection_Homo sapiens_hsa051501.10406423
54Drug metabolism - other enzymes_Homo sapiens_hsa009831.06614650
55ECM-receptor interaction_Homo sapiens_hsa045121.04512830
56Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03935304
57Fat digestion and absorption_Homo sapiens_hsa049751.03030854
58Insulin resistance_Homo sapiens_hsa049311.01807753
59Tyrosine metabolism_Homo sapiens_hsa003500.99245709
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.97769788
61Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94986504
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.93913205
63Other glycan degradation_Homo sapiens_hsa005110.93690053
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.93231181
65Fructose and mannose metabolism_Homo sapiens_hsa000510.92849399
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92340271
67Carbon metabolism_Homo sapiens_hsa012000.91930172
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.91232530
69Renal cell carcinoma_Homo sapiens_hsa052110.90818389
70Spliceosome_Homo sapiens_hsa030400.90269125
71HTLV-I infection_Homo sapiens_hsa051660.89084379
72Vitamin digestion and absorption_Homo sapiens_hsa049770.87536132
73p53 signaling pathway_Homo sapiens_hsa041150.85994289
74* Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85184492
75Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.83368183
76Glucagon signaling pathway_Homo sapiens_hsa049220.82854914
77Sulfur metabolism_Homo sapiens_hsa009200.82494769
78Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.81422931
79Dorso-ventral axis formation_Homo sapiens_hsa043200.80130327
80Adipocytokine signaling pathway_Homo sapiens_hsa049200.78904533
81Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.78569322
82Glycerolipid metabolism_Homo sapiens_hsa005610.76741154
83Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.76721533
84AMPK signaling pathway_Homo sapiens_hsa041520.76051265
85Dilated cardiomyopathy_Homo sapiens_hsa054140.75846363
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.75159651
87Glioma_Homo sapiens_hsa052140.74082479
88Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.73038293
89Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72225412
90Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.72168512
91Colorectal cancer_Homo sapiens_hsa052100.71959278
92Base excision repair_Homo sapiens_hsa034100.71377349
93Type II diabetes mellitus_Homo sapiens_hsa049300.71115774
94VEGF signaling pathway_Homo sapiens_hsa043700.70487447
95Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70393997
96B cell receptor signaling pathway_Homo sapiens_hsa046620.69123564
97Small cell lung cancer_Homo sapiens_hsa052220.68674308
98Biosynthesis of amino acids_Homo sapiens_hsa012300.66639540
99Fatty acid elongation_Homo sapiens_hsa000620.66549683
100Apoptosis_Homo sapiens_hsa042100.65367024
101Arginine and proline metabolism_Homo sapiens_hsa003300.65346933
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.64943766
103Hepatitis B_Homo sapiens_hsa051610.64195197
104Focal adhesion_Homo sapiens_hsa045100.62721599
105Protein digestion and absorption_Homo sapiens_hsa049740.62520667
106Viral myocarditis_Homo sapiens_hsa054160.62293931
107Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60536976
108Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.60258246
109Prolactin signaling pathway_Homo sapiens_hsa049170.59971813
110Pathways in cancer_Homo sapiens_hsa052000.58464733
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.58375668
112Systemic lupus erythematosus_Homo sapiens_hsa053220.57013776
113RNA degradation_Homo sapiens_hsa030180.56916153
114Cysteine and methionine metabolism_Homo sapiens_hsa002700.56432624
115Toxoplasmosis_Homo sapiens_hsa051450.56104776
116Measles_Homo sapiens_hsa051620.55238285
117Herpes simplex infection_Homo sapiens_hsa051680.55052258
118Leukocyte transendothelial migration_Homo sapiens_hsa046700.54847595
119Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54115400
120Legionellosis_Homo sapiens_hsa051340.53608178
121Ovarian steroidogenesis_Homo sapiens_hsa049130.53141609
122Insulin signaling pathway_Homo sapiens_hsa049100.52050644
123Tight junction_Homo sapiens_hsa045300.51285339
124Hepatitis C_Homo sapiens_hsa051600.51104289
125TGF-beta signaling pathway_Homo sapiens_hsa043500.50781006
126Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.50596532
127T cell receptor signaling pathway_Homo sapiens_hsa046600.50244630
128TNF signaling pathway_Homo sapiens_hsa046680.50228306
129Inositol phosphate metabolism_Homo sapiens_hsa005620.49782992
130N-Glycan biosynthesis_Homo sapiens_hsa005100.49098101
131RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.49007374
132Amoebiasis_Homo sapiens_hsa051460.48859358
133ErbB signaling pathway_Homo sapiens_hsa040120.47965262
134Jak-STAT signaling pathway_Homo sapiens_hsa046300.45846641
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44745044
136Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.43370988
137Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.40145429
138Central carbon metabolism in cancer_Homo sapiens_hsa052300.37991565
139Proteoglycans in cancer_Homo sapiens_hsa052050.33545524
140Adherens junction_Homo sapiens_hsa045200.33326475
141Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32781032
142Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.29052494
143Chronic myeloid leukemia_Homo sapiens_hsa052200.24788188
144MicroRNAs in cancer_Homo sapiens_hsa052060.21608480
145Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.19649089
146Galactose metabolism_Homo sapiens_hsa000520.19251209
147PI3K-Akt signaling pathway_Homo sapiens_hsa041510.18872690
148Glycosaminoglycan degradation_Homo sapiens_hsa005310.18798900
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.17205349
150Bladder cancer_Homo sapiens_hsa052190.16671486
151Circadian rhythm_Homo sapiens_hsa047100.16653130
152FoxO signaling pathway_Homo sapiens_hsa040680.16601350
153Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.16156161
154Melanoma_Homo sapiens_hsa052180.16092730
155Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.15459902
156mTOR signaling pathway_Homo sapiens_hsa041500.15455080
157Prostate cancer_Homo sapiens_hsa052150.15087179

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