CUL4B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the cullin family. The encoded protein forms a complex that functions as an E3 ubiquitin ligase and catalyzes the polyubiquitination of specific protein substrates in the cell. The protein interacts with a ring finger protein, and is required for the proteolysis of several regulators of DNA replication including chromatin licensing and DNA replication factor 1 and cyclin E. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)6.19246937
2nuclear pore organization (GO:0006999)6.19032717
3Golgi transport vesicle coating (GO:0048200)5.17258681
4COPI coating of Golgi vesicle (GO:0048205)5.17258681
5regulation of gene silencing by miRNA (GO:0060964)4.93236397
6regulation of gene silencing by RNA (GO:0060966)4.93236397
7regulation of posttranscriptional gene silencing (GO:0060147)4.93236397
8protein localization to kinetochore (GO:0034501)4.80243380
9mitotic nuclear envelope disassembly (GO:0007077)4.59179168
10pore complex assembly (GO:0046931)4.58850631
11pre-miRNA processing (GO:0031054)4.54675141
12mitotic metaphase plate congression (GO:0007080)4.38572135
13DNA replication-dependent nucleosome organization (GO:0034723)4.35481882
14DNA replication-dependent nucleosome assembly (GO:0006335)4.35481882
15membrane disassembly (GO:0030397)4.34030541
16nuclear envelope disassembly (GO:0051081)4.34030541
17DNA unwinding involved in DNA replication (GO:0006268)4.32237431
18heterochromatin organization (GO:0070828)4.23664845
19mitotic sister chromatid cohesion (GO:0007064)4.19714237
20regulation of transforming growth factor beta2 production (GO:0032909)4.17924527
21mitotic chromosome condensation (GO:0007076)4.16184624
22cell adhesion mediated by integrin (GO:0033627)4.15342376
23folic acid-containing compound biosynthetic process (GO:0009396)4.10622189
24regulation of helicase activity (GO:0051095)4.03809057
25negative regulation of histone methylation (GO:0031061)4.02506164
26mitotic sister chromatid segregation (GO:0000070)3.99857021
27metaphase plate congression (GO:0051310)3.97018803
28protein localization to chromosome, centromeric region (GO:0071459)3.96681476
29DNA replication initiation (GO:0006270)3.90533832
30COPII vesicle coating (GO:0048208)3.90388708
31sister chromatid segregation (GO:0000819)3.89528926
32regulation of histone H3-K9 methylation (GO:0051570)3.88987083
33regulation of spindle organization (GO:0090224)3.84654110
34positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.77482866
35positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.77482866
36positive regulation of mitotic sister chromatid separation (GO:1901970)3.77482866
37collagen fibril organization (GO:0030199)3.74385381
38DNA geometric change (GO:0032392)3.73380142
39DNA duplex unwinding (GO:0032508)3.72803688
40positive regulation of chromosome segregation (GO:0051984)3.71103092
41regulation of sister chromatid cohesion (GO:0007063)3.70474469
42somatic hypermutation of immunoglobulin genes (GO:0016446)3.70453708
43somatic diversification of immune receptors via somatic mutation (GO:0002566)3.70453708
44IMP biosynthetic process (GO:0006188)3.69570170
45regulation of mitotic spindle organization (GO:0060236)3.66121341
46protein K6-linked ubiquitination (GO:0085020)3.61714942
47regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60437681
48paraxial mesoderm development (GO:0048339)3.58879697
49nucleobase biosynthetic process (GO:0046112)3.58383745
50vesicle coating (GO:0006901)3.54071430
51attachment of spindle microtubules to kinetochore (GO:0008608)3.52770474
52regulation of translational termination (GO:0006449)3.52279361
53ribosome assembly (GO:0042255)3.50446459
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.49009872
55kinetochore organization (GO:0051383)3.48569375
56embryonic process involved in female pregnancy (GO:0060136)3.47842992
57skin morphogenesis (GO:0043589)3.47773763
58establishment of chromosome localization (GO:0051303)3.47619248
59chromatin assembly (GO:0031497)3.45140328
60regulation of RNA export from nucleus (GO:0046831)3.44420823
61DNA replication checkpoint (GO:0000076)3.40614777
62regulation of centrosome cycle (GO:0046605)3.39789145
63IMP metabolic process (GO:0046040)3.38038360
64chromatin remodeling at centromere (GO:0031055)3.37707232
65regulation of centriole replication (GO:0046599)3.37312326
66histone H4-K12 acetylation (GO:0043983)3.36961044
67regulation of chromosome segregation (GO:0051983)3.36018174
68purine nucleobase biosynthetic process (GO:0009113)3.34238059
69protein retention in ER lumen (GO:0006621)3.33957691
70regulation of telomere maintenance via telomerase (GO:0032210)3.32760933
71nuclear envelope organization (GO:0006998)3.30195881
72regulation of translational fidelity (GO:0006450)3.30150486
73dosage compensation (GO:0007549)3.28863336
74DNA strand elongation involved in DNA replication (GO:0006271)3.27343796
75spindle checkpoint (GO:0031577)3.25932235
76protein localization to chromosome (GO:0034502)3.25369702
77negative regulation of chromosome segregation (GO:0051985)3.25316352
78negative regulation of DNA repair (GO:0045738)3.24510105
79regulation of mitotic metaphase/anaphase transition (GO:0030071)3.24324858
80chondrocyte development (GO:0002063)3.23822777
81meiotic chromosome segregation (GO:0045132)3.23488578
82DNA replication-independent nucleosome organization (GO:0034724)3.22225367
83DNA replication-independent nucleosome assembly (GO:0006336)3.22225367
84regulation of gene silencing (GO:0060968)3.21279614
85formation of translation preinitiation complex (GO:0001731)3.19183450
86chromatin assembly or disassembly (GO:0006333)3.18827251
87spindle assembly checkpoint (GO:0071173)3.18620987
88positive regulation of SMAD protein import into nucleus (GO:0060391)3.17906300
89regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.17461220
90mitotic spindle checkpoint (GO:0071174)3.17311739
91negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.15761411
92negative regulation of sister chromatid segregation (GO:0033046)3.15761411
93negative regulation of mitotic sister chromatid separation (GO:2000816)3.15761411
94negative regulation of mitotic sister chromatid segregation (GO:0033048)3.15761411
95mitotic spindle assembly checkpoint (GO:0007094)3.13821876
96regulation of mitotic sister chromatid segregation (GO:0033047)3.12760484
97regulation of sister chromatid segregation (GO:0033045)3.12760484
98regulation of mitotic sister chromatid separation (GO:0010965)3.12760484
99CENP-A containing nucleosome assembly (GO:0034080)3.12100517
100DNA strand elongation (GO:0022616)3.10114651
101histone exchange (GO:0043486)3.08609141
102negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.07130922
103chromosome segregation (GO:0007059)3.05992686
104retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.04967345
105DNA conformation change (GO:0071103)3.04947095
106positive regulation of blood vessel endothelial cell migration (GO:0043536)3.04464488
107mRNA transport (GO:0051028)3.03446058
108* histone H2A monoubiquitination (GO:0035518)3.01779668
109regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.00875456
110substrate-dependent cell migration (GO:0006929)3.00201688
111kidney mesenchyme development (GO:0072074)2.99757898
112gene silencing by RNA (GO:0031047)2.99502929
113kinetochore assembly (GO:0051382)2.94800117
114regulation of centrosome duplication (GO:0010824)2.93852158
115endocardial cushion development (GO:0003197)2.92899649
116negative regulation of fatty acid transport (GO:2000192)2.92471339
117determination of adult lifespan (GO:0008340)2.92134559
118hypotonic response (GO:0006971)2.91273854
119metanephric mesenchyme development (GO:0072075)2.90715122
120anterior/posterior axis specification, embryo (GO:0008595)2.89262192
121regulation of cardioblast differentiation (GO:0051890)2.88587268
122fibroblast migration (GO:0010761)2.88468768
123positive regulation of cell size (GO:0045793)2.87970134
124retina vasculature morphogenesis in camera-type eye (GO:0061299)2.87844216
125protein localization to endosome (GO:0036010)2.84980820
126chondrocyte proliferation (GO:0035988)2.82344852
127negative regulation of fibroblast apoptotic process (GO:2000270)2.82282906
128regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.81250651
129hippo signaling (GO:0035329)2.79744421
130mesenchymal-epithelial cell signaling (GO:0060638)2.77939705
131positive regulation of male gonad development (GO:2000020)2.76609393
132cell migration involved in sprouting angiogenesis (GO:0002042)2.76306739
133regulation of nucleobase-containing compound transport (GO:0032239)2.74136237
134mesodermal cell differentiation (GO:0048333)2.73393689
135cellular response to interferon-alpha (GO:0035457)2.70867974
136endodermal cell differentiation (GO:0035987)2.69986851
137negative regulation of axon extension involved in axon guidance (GO:0048843)2.69464671
138positive regulation of receptor recycling (GO:0001921)2.67214793
139negative regulation of anoikis (GO:2000811)2.65897975
140peptidyl-proline hydroxylation (GO:0019511)2.64790050
141hemoglobin metabolic process (GO:0020027)2.64271887
142sequestering of extracellular ligand from receptor (GO:0035581)2.63572686
143negative regulation of stem cell proliferation (GO:2000647)2.63206884
144planar cell polarity pathway involved in neural tube closure (GO:0090179)2.62081100
145protein hydroxylation (GO:0018126)2.61837448
146cytoskeleton-dependent cytokinesis (GO:0061640)2.60346863
147spermatid nucleus differentiation (GO:0007289)2.58022481
148regulation of cAMP-dependent protein kinase activity (GO:2000479)2.57816749
149negative regulation of protein localization to plasma membrane (GO:1903077)2.54826085
150regulation of transforming growth factor beta1 production (GO:0032908)2.54712538
151regulation of early endosome to late endosome transport (GO:2000641)2.53329208
152negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.52141894
153blood vessel maturation (GO:0001955)2.51438928
154mitotic cytokinesis (GO:0000281)2.51337394
155NLS-bearing protein import into nucleus (GO:0006607)2.49308551
156negative regulation of chondrocyte differentiation (GO:0032331)2.48195654
157mammary gland epithelial cell proliferation (GO:0033598)2.47846892
158cell-substrate junction assembly (GO:0007044)2.45639074
159positive regulation of fibroblast migration (GO:0010763)2.42808544
160response to follicle-stimulating hormone (GO:0032354)2.39323037
161regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.38444691
162blood vessel endothelial cell migration (GO:0043534)2.37665778
163protein localization to microtubule (GO:0035372)2.36384441
164adherens junction assembly (GO:0034333)2.34123879
165basement membrane organization (GO:0071711)2.32983217
166membrane protein ectodomain proteolysis (GO:0006509)2.32106283
167endothelial cell morphogenesis (GO:0001886)2.31752306
168establishment of integrated proviral latency (GO:0075713)2.30440520
169cellular response to follicle-stimulating hormone stimulus (GO:0071372)2.29738618
170extracellular matrix assembly (GO:0085029)2.29680463
171regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.29239451
172wound healing, spreading of epidermal cells (GO:0035313)2.28853274
173dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.27540522
174platelet-derived growth factor receptor signaling pathway (GO:0048008)2.26872326
175cytoplasmic mRNA processing body assembly (GO:0033962)2.25603472
176negative regulation of axon guidance (GO:1902668)2.24154867
177cortical actin cytoskeleton organization (GO:0030866)2.24109979
178vascular endothelial growth factor signaling pathway (GO:0038084)2.24031623
179sprouting angiogenesis (GO:0002040)2.23169774
180SMAD protein complex assembly (GO:0007183)2.22291641
181regulation of axon extension involved in axon guidance (GO:0048841)2.21431337
182protein export from nucleus (GO:0006611)2.20757410
183cell-substrate adherens junction assembly (GO:0007045)2.20196332
184focal adhesion assembly (GO:0048041)2.20196332
185glomerular basement membrane development (GO:0032836)2.20038730
186positive regulation of endothelial cell migration (GO:0010595)2.19367369
187regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.19284794
188regulation of transforming growth factor beta production (GO:0071634)2.19230305
189substrate adhesion-dependent cell spreading (GO:0034446)2.19154461

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.76593770
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.09273886
3WT1_19549856_ChIP-ChIP_CCG9911_Human3.87128596
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.84667586
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.60626821
6SMAD_19615063_ChIP-ChIP_OVARY_Human3.23601109
7FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.22103429
8CLOCK_20551151_ChIP-Seq_293T_Human3.05186393
9* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.99487472
10TRIM28_21343339_ChIP-Seq_HEK293_Human2.97458190
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.90070658
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.86909710
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.82092010
14BRD4_25478319_ChIP-Seq_HGPS_Human2.64286126
15KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.63022418
16KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.63022418
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.63022418
18TCF3_18467660_ChIP-ChIP_MESCs_Mouse2.60103245
19FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.54263772
20SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.52506579
21AR_21909140_ChIP-Seq_LNCAP_Human2.47246675
22SALL4_18804426_ChIP-ChIP_XEN_Mouse2.45243666
23MYC_19030024_ChIP-ChIP_MESCs_Mouse2.44396818
24POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.37405248
25SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.31762603
26NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30768285
27* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.27501830
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26432569
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22677676
30E2F1_21310950_ChIP-Seq_MCF-7_Human2.19171781
31NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.08817649
32* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.03881778
33SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse2.02306852
34CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.99398175
35WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.95748775
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.95223547
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.93144649
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.91569339
39POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.90542936
40CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.90139518
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.89636474
42ESR1_15608294_ChIP-ChIP_MCF-7_Human1.84227400
43ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83317501
44* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.82106015
45TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.79066580
46STAT3_1855785_ChIP-Seq_MESCs_Mouse1.78744217
47SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.77260865
48TCF3_18692474_ChIP-Seq_MEFs_Mouse1.76668519
49NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.73829842
50ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.71714758
51ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.71557219
52XRN2_22483619_ChIP-Seq_HELA_Human1.71305854
53SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.70991396
54SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.70991396
55CJUN_26792858_Chip-Seq_BT549_Human1.70684955
56SOX2_18555785_ChIP-Seq_MESCs_Mouse1.67108141
57NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.66385314
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.66385314
59* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.65969836
60TCF3_18692474_ChIP-Seq_MESCs_Mouse1.61783025
61EST1_17652178_ChIP-ChIP_JURKAT_Human1.57601982
62EP300_21415370_ChIP-Seq_HL-1_Mouse1.56822005
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.56600806
64MYC_22102868_ChIP-Seq_BL_Human1.56462379
65TP63_19390658_ChIP-ChIP_HaCaT_Human1.55175314
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54734817
67CREB1_15753290_ChIP-ChIP_HEK293T_Human1.53814438
68RBPJ_22232070_ChIP-Seq_NCS_Mouse1.53789772
69RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.53596662
70KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.51795407
71P300_27058665_Chip-Seq_ZR-75-30cells_Human1.49977925
72POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48342263
73ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.48210440
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47836670
75ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47816140
76NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.46790725
77FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.46707066
78KLF4_18555785_ChIP-Seq_MESCs_Mouse1.45646944
79FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.43535800
80SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.43454027
81RARG_19884340_ChIP-ChIP_MEFs_Mouse1.43211960
82ETS1_20019798_ChIP-Seq_JURKAT_Human1.42032689
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.41438688
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41313078
85KDM5A_27292631_Chip-Seq_BREAST_Human1.38340209
86NANOG_21062744_ChIP-ChIP_HESCs_Human1.37230762
87GATA2_21666600_ChIP-Seq_HMVEC_Human1.37040256
88SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.36289215
89VDR_23849224_ChIP-Seq_CD4+_Human1.34795830
90FOXO3_23340844_ChIP-Seq_DLD1_Human1.34471682
91FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.32327411
92TP63_17297297_ChIP-ChIP_HaCaT_Human1.32188909
93MYB_21317192_ChIP-Seq_ERMYB_Mouse1.31213273
94PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29679047
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.29062018
96KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.28822441
97SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.27579977
98TTF2_22483619_ChIP-Seq_HELA_Human1.26515361
99HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.24667187
100NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.24408319
101FOXP3_21729870_ChIP-Seq_TREG_Human1.24065917
102HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.23065243
103TFEB_21752829_ChIP-Seq_HELA_Human1.22473893
104GABP_17652178_ChIP-ChIP_JURKAT_Human1.22179581
105TP53_18474530_ChIP-ChIP_U2OS_Human1.21278084
106KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19364470
107PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.18922534
108ELK1_19687146_ChIP-ChIP_HELA_Human1.18917138
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.18586495
110GABP_19822575_ChIP-Seq_HepG2_Human1.18123846
111CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17330970
112TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16748394
113YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16737225
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.12876828
115DCP1A_22483619_ChIP-Seq_HELA_Human1.12352837
116KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12259979
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.11678529
118UBF1/2_26484160_Chip-Seq_HMECs_Human1.11105342
119POU5F1_16518401_ChIP-PET_MESCs_Mouse1.11024420
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10557366
121PADI4_21655091_ChIP-ChIP_MCF-7_Human1.10343042
122TCF4_18268006_ChIP-ChIP_LS174T_Human1.09452207
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.08924194
124* SOX17_20123909_ChIP-Seq_XEN_Mouse1.07776516
125Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.07748787
126SOX9_24532713_ChIP-Seq_HFSC_Mouse1.07746207
127JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.07610683
128* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07024026
129NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.06745124
130EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.06145709
131CTNNB1_20460455_ChIP-Seq_HCT116_Human1.05500426
132FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05355921
133* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.04596510
134CIITA_25753668_ChIP-Seq_RAJI_Human1.04213570
135* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.04070669
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.03091360
137FUS_26573619_Chip-Seq_HEK293_Human1.02821016
138MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.02615101
139ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02420784
140CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.01651165
141TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01616376
142TP53_16413492_ChIP-PET_HCT116_Human1.01471441
143TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00643329
144THAP11_20581084_ChIP-Seq_MESCs_Mouse0.99781558
145TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99617854
146TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.99494504
147DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99346846
148FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.98759760
149KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.98753689
150PIAS1_25552417_ChIP-Seq_VCAP_Human0.96950429
151E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.96358381
152EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.96265295
153* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.94565166
154NANOG_18692474_ChIP-Seq_MESCs_Mouse0.94303160
155OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93746336
156NANOG_18692474_ChIP-Seq_MEFs_Mouse0.92882423
157GATA4_21415370_ChIP-Seq_HL-1_Mouse0.92793797
158AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.92010206
159NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91335878
160PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.90559209
161CHD1_26751641_Chip-Seq_LNCaP_Human0.90473455
162TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89810383
163NFIB_24661679_ChIP-Seq_LUNG_Mouse0.88883480
164NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.88189293
165CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86786225
166POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.86411076
167POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85106770
168ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84813445
169OCT4_18692474_ChIP-Seq_MEFs_Mouse0.84765076
170HIF1A_21447827_ChIP-Seq_MCF-7_Human0.84176093
171NANOG_16518401_ChIP-PET_MESCs_Mouse0.83318942

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen5.41741362
2MP0010094_abnormal_chromosome_stability4.02384671
3MP0004957_abnormal_blastocyst_morpholog3.89424447
4MP0003693_abnormal_embryo_hatching3.79945918
5MP0003111_abnormal_nucleus_morphology3.68765729
6MP0008057_abnormal_DNA_replication3.67216350
7MP0003077_abnormal_cell_cycle3.44731840
8MP0010352_gastrointestinal_tract_polyps3.17016649
9MP0003123_paternal_imprinting3.02245157
10MP0003705_abnormal_hypodermis_morpholog2.65703063
11MP0005275_abnormal_skin_tensile2.62816158
12MP0008877_abnormal_DNA_methylation2.62512027
13MP0001730_embryonic_growth_arrest2.61339562
14MP0010307_abnormal_tumor_latency2.58476952
15MP0005503_abnormal_tendon_morphology2.53633668
16MP0008058_abnormal_DNA_repair2.49441686
17MP0010368_abnormal_lymphatic_system2.48851769
18MP0000350_abnormal_cell_proliferation2.36852379
19MP0003279_aneurysm2.26640307
20MP0008007_abnormal_cellular_replicative2.26329978
21MP0005076_abnormal_cell_differentiation2.24126070
22MP0005257_abnormal_intraocular_pressure2.20847467
23MP0005380_embryogenesis_phenotype2.19438574
24MP0001672_abnormal_embryogenesis/_devel2.19438574
25* MP0002084_abnormal_developmental_patter2.17820650
26MP0003121_genomic_imprinting2.15564708
27MP0004197_abnormal_fetal_growth/weight/2.06066702
28MP0001697_abnormal_embryo_size2.05058289
29MP0003890_abnormal_embryonic-extraembry2.03715334
30MP0002086_abnormal_extraembryonic_tissu2.02892982
31MP0008932_abnormal_embryonic_tissue2.02427132
32MP0002085_abnormal_embryonic_tissue1.99553444
33MP0003984_embryonic_growth_retardation1.98361292
34MP0003950_abnormal_plasma_membrane1.98147636
35MP0001958_emphysema1.95977151
36MP0002088_abnormal_embryonic_growth/wei1.95329436
37MP0009384_cardiac_valve_regurgitation1.89984076
38MP0004264_abnormal_extraembryonic_tissu1.81684438
39MP0002009_preneoplasia1.80640207
40MP0002653_abnormal_ependyma_morphology1.78044081
41MP0003385_abnormal_body_wall1.69169667
42MP0000013_abnormal_adipose_tissue1.68912266
43MP0003567_abnormal_fetal_cardiomyocyte1.66958741
44MP0002080_prenatal_lethality1.66813049
45MP0001299_abnormal_eye_distance/1.64980946
46MP0009697_abnormal_copulation1.63657428
47MP0008004_abnormal_stomach_pH1.61992173
48MP0003806_abnormal_nucleotide_metabolis1.60462093
49MP0003300_gastrointestinal_ulcer1.55347067
50MP0010234_abnormal_vibrissa_follicle1.55021768
51MP0000767_abnormal_smooth_muscle1.53111365
52MP0003786_premature_aging1.51753649
53MP0009053_abnormal_anal_canal1.50562999
54MP0002896_abnormal_bone_mineralization1.49912585
55MP0003119_abnormal_digestive_system1.49665239
56MP0003566_abnormal_cell_adhesion1.49362216
57MP0001879_abnormal_lymphatic_vessel1.49061149
58MP0002877_abnormal_melanocyte_morpholog1.48352103
59MP0002060_abnormal_skin_morphology1.43421861
60MP0001293_anophthalmia1.43146684
61MP0004133_heterotaxia1.42495742
62MP0005623_abnormal_meninges_morphology1.36920962
63MP0000534_abnormal_ureter_morphology1.36141662
64MP0009780_abnormal_chondrocyte_physiolo1.35850908
65MP0003942_abnormal_urinary_system1.34403033
66MP0002210_abnormal_sex_determination1.31540721
67MP0003937_abnormal_limbs/digits/tail_de1.30653573
68MP0003941_abnormal_skin_development1.29980240
69MP0002396_abnormal_hematopoietic_system1.28501707
70MP0000537_abnormal_urethra_morphology1.27940332
71MP0000762_abnormal_tongue_morphology1.26103878
72MP0003718_maternal_effect1.25712898
73MP0005508_abnormal_skeleton_morphology1.24790941
74MP0010030_abnormal_orbit_morphology1.24463640
75MP0001145_abnormal_male_reproductive1.21135508
76MP0001915_intracranial_hemorrhage1.20364031
77MP0001849_ear_inflammation1.20066023
78MP0009703_decreased_birth_body1.17900972
79MP0005023_abnormal_wound_healing1.13650865
80MP0009672_abnormal_birth_weight1.12779739
81MP0003283_abnormal_digestive_organ1.12059235
82MP0003828_pulmonary_edema1.11021512
83MP0000313_abnormal_cell_death1.10859847
84MP0001661_extended_life_span1.10674446
85MP0001929_abnormal_gametogenesis1.09922589
86MP0002019_abnormal_tumor_incidence1.06419165
87MP0009250_abnormal_appendicular_skeleto1.06170946
88MP0000653_abnormal_sex_gland1.05496457
89MP0004185_abnormal_adipocyte_glucose1.03410597
90MP0000490_abnormal_crypts_of1.01420737
91MP0001243_abnormal_dermal_layer0.97710980
92MP0002111_abnormal_tail_morphology0.97503617
93MP0000428_abnormal_craniofacial_morphol0.96647509
94MP0001348_abnormal_lacrimal_gland0.96581952
95MP0003787_abnormal_imprinting0.95385607
96MP0002697_abnormal_eye_size0.94671238
97MP0000432_abnormal_head_morphology0.92389500
98MP0002128_abnormal_blood_circulation0.91948828
99MP0002092_abnormal_eye_morphology0.90498917
100MP0002925_abnormal_cardiovascular_devel0.89881981
101MP0001614_abnormal_blood_vessel0.89345795
102MP0005367_renal/urinary_system_phenotyp0.88923056
103MP0000516_abnormal_urinary_system0.88923056
104MP0002295_abnormal_pulmonary_circulatio0.88397737
105MP0001286_abnormal_eye_development0.86649171
106MP0005621_abnormal_cell_physiology0.85349584
107MP0002108_abnormal_muscle_morphology0.84851732
108MP0005384_cellular_phenotype0.83802880
109MP0005197_abnormal_uvea_morphology0.82819225
110MP0000733_abnormal_muscle_development0.82259737
111MP0003935_abnormal_craniofacial_develop0.82159085
112MP0002114_abnormal_axial_skeleton0.81741509
113MP0004808_abnormal_hematopoietic_stem0.81624632
114MP0005409_darkened_coat_color0.81334848
115MP0002233_abnormal_nose_morphology0.78863317
116MP0003861_abnormal_nervous_system0.78266752
117MP0000003_abnormal_adipose_tissue0.78171163
118MP0003448_altered_tumor_morphology0.76588955
119MP0005193_abnormal_anterior_eye0.76460402
120MP0006054_spinal_hemorrhage0.76369576
121MP0004134_abnormal_chest_morphology0.76039788
122MP0003115_abnormal_respiratory_system0.75911398
123MP0000462_abnormal_digestive_system0.75848781
124MP0001119_abnormal_female_reproductive0.75671654
125MP0000639_abnormal_adrenal_gland0.74872198
126MP0001175_abnormal_lung_morphology0.74556722
127MP0004858_abnormal_nervous_system0.74420988
128MP0003755_abnormal_palate_morphology0.74245475
129MP0000163_abnormal_cartilage_morphology0.71572119
130MP0004233_abnormal_muscle_weight0.71058052
131MP0003315_abnormal_perineum_morphology0.68549839
132MP0003221_abnormal_cardiomyocyte_apopto0.68237994
133MP0003936_abnormal_reproductive_system0.66837730
134MP0000266_abnormal_heart_morphology0.64390432
135MP0002160_abnormal_reproductive_system0.62436431
136MP0003699_abnormal_female_reproductive0.61923685
137MP0005266_abnormal_metabolism0.60058767
138MP0000477_abnormal_intestine_morphology0.60058368
139MP0003091_abnormal_cell_migration0.59966239
140MP0000358_abnormal_cell_content/0.59960840
141MP0001545_abnormal_hematopoietic_system0.57760041
142MP0005397_hematopoietic_system_phenotyp0.57760041
143MP0003698_abnormal_male_reproductive0.57654585
144MP0000627_abnormal_mammary_gland0.56941027
145MP0004272_abnormal_basement_membrane0.56904317
146MP0005389_reproductive_system_phenotype0.56881223
147MP0005187_abnormal_penis_morphology0.56758337

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.26085689
2Premature rupture of membranes (HP:0001788)5.05112792
3Ependymoma (HP:0002888)4.94580106
4Vascular tortuosity (HP:0004948)4.25935721
5Arterial tortuosity (HP:0005116)4.22622351
6Abnormality of the labia minora (HP:0012880)3.98010430
7Astrocytoma (HP:0009592)3.90126621
8Abnormality of the astrocytes (HP:0100707)3.90126621
9Medulloblastoma (HP:0002885)3.89569740
10Chromsome breakage (HP:0040012)3.87219729
11Rhabdomyosarcoma (HP:0002859)3.60594713
12Neoplasm of the oral cavity (HP:0100649)3.51944444
13Aortic dissection (HP:0002647)3.44592738
14Selective tooth agenesis (HP:0001592)3.44575234
15Chromosomal breakage induced by crosslinking agents (HP:0003221)3.43944244
16Aortic aneurysm (HP:0004942)3.37105752
17Colon cancer (HP:0003003)3.35372454
18Glioma (HP:0009733)3.24765461
19Agnosia (HP:0010524)3.21459969
20Spinal cord lesions (HP:0100561)3.15909124
21Syringomyelia (HP:0003396)3.15909124
22Volvulus (HP:0002580)3.10328301
23Birth length less than 3rd percentile (HP:0003561)3.06041741
24Abnormality of chromosome stability (HP:0003220)3.03481540
25Biliary tract neoplasm (HP:0100574)2.98337916
26Abnormality of dentin (HP:0010299)2.97613111
27Neoplasm of striated muscle (HP:0009728)2.92898843
28Missing ribs (HP:0000921)2.90051551
29Deviation of the thumb (HP:0009603)2.87113822
30Wormian bones (HP:0002645)2.84584437
31Absent frontal sinuses (HP:0002688)2.83744741
32Absent radius (HP:0003974)2.83100335
33Aplasia/hypoplasia of the humerus (HP:0006507)2.77706825
34Short humerus (HP:0005792)2.77399889
35Proximal placement of thumb (HP:0009623)2.75398204
36Shawl scrotum (HP:0000049)2.74825756
37Breast hypoplasia (HP:0003187)2.74575067
38Impulsivity (HP:0100710)2.72454379
39Supernumerary spleens (HP:0009799)2.70738928
40Cervical subluxation (HP:0003308)2.70103306
41Soft skin (HP:0000977)2.65371713
42Spondylolisthesis (HP:0003302)2.63954091
43Absent forearm bone (HP:0003953)2.62604863
44Aplasia involving forearm bones (HP:0009822)2.62604863
45Atrophic scars (HP:0001075)2.56683569
46Osteolytic defects of the hand bones (HP:0009699)2.56457528
47Osteolytic defects of the phalanges of the hand (HP:0009771)2.56457528
48Facial hemangioma (HP:0000329)2.56355281
49Patellar aplasia (HP:0006443)2.55250299
50Increased nuchal translucency (HP:0010880)2.53076059
51Meckel diverticulum (HP:0002245)2.52124917
52Aplasia/Hypoplasia of the uvula (HP:0010293)2.52036124
53Overgrowth (HP:0001548)2.51167026
54Large earlobe (HP:0009748)2.50079233
55Basal cell carcinoma (HP:0002671)2.49715503
56Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.48907889
57Spinal rigidity (HP:0003306)2.47122519
58Rhizomelia (HP:0008905)2.43848003
59Abnormality of the ileum (HP:0001549)2.39254716
60Rib fusion (HP:0000902)2.38403852
61Mitral valve prolapse (HP:0001634)2.36740947
62Gastrointestinal carcinoma (HP:0002672)2.36283219
63Malignant gastrointestinal tract tumors (HP:0006749)2.36283219
64Vertebral arch anomaly (HP:0008438)2.34838046
65Abnormality of abdominal situs (HP:0011620)2.34390936
66Abdominal situs inversus (HP:0003363)2.34390936
67Ectopic kidney (HP:0000086)2.33257084
68Dilatation of the ascending aorta (HP:0005111)2.33030586
69Shallow orbits (HP:0000586)2.32272202
70Aplasia/Hypoplasia of the patella (HP:0006498)2.31944325
71Neonatal short-limb short stature (HP:0008921)2.29604611
72Short nail (HP:0001799)2.25846075
73Insidious onset (HP:0003587)2.25683734
74Termporal pattern (HP:0011008)2.25683734
75* Relative macrocephaly (HP:0004482)2.23185922
76Cafe-au-lait spot (HP:0000957)2.22534829
77Mitral stenosis (HP:0001718)2.22086627
78Degeneration of anterior horn cells (HP:0002398)2.21943456
79Abnormality of the anterior horn cell (HP:0006802)2.21943456
80Myelodysplasia (HP:0002863)2.21101480
81Bladder diverticulum (HP:0000015)2.20744828
82Abnormality of the preputium (HP:0100587)2.20193802
83Ulnar bowing (HP:0003031)2.19023219
84* Joint laxity (HP:0001388)2.18431404
85Vertebral compression fractures (HP:0002953)2.17108671
86Sparse lateral eyebrow (HP:0005338)2.16516364
87Short clavicles (HP:0000894)2.16157936
88Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.15691233
89Duodenal stenosis (HP:0100867)2.14421240
90Small intestinal stenosis (HP:0012848)2.14421240
91Ankle contracture (HP:0006466)2.12553417
92Fragile skin (HP:0001030)2.11222117
93Abnormality of the lower motor neuron (HP:0002366)2.10863929
94Abnormality of the acetabulum (HP:0003170)2.10285939
95Aplasia/Hypoplasia of the sternum (HP:0006714)2.09825413
96Neoplasm of the pancreas (HP:0002894)2.08980556
97Short middle phalanx of the 5th finger (HP:0004220)2.08287390
98Delayed closure of the anterior fontanelle (HP:0001476)2.06553803
99Aplasia/Hypoplasia involving the sinuses (HP:0009120)2.06444124
100Short 4th metacarpal (HP:0010044)2.05094962
101Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.05094962
102Decreased skull ossification (HP:0004331)2.05087341
103Amaurosis fugax (HP:0100576)2.04699208
104Absent thumb (HP:0009777)2.04063778
105Heterotopia (HP:0002282)2.03930984
106Carpal bone hypoplasia (HP:0001498)2.03682671
107Mitral regurgitation (HP:0001653)2.02768469
108Abnormal number of incisors (HP:0011064)2.01934636
109Ovarian neoplasm (HP:0100615)2.01367063
110Aneurysm (HP:0002617)2.01261235
111Esophageal atresia (HP:0002032)2.01004334
112Asymmetry of the thorax (HP:0001555)2.00836773
113Papillary thyroid carcinoma (HP:0002895)2.00268571
114Nephroblastoma (Wilms tumor) (HP:0002667)2.00087925
11511 pairs of ribs (HP:0000878)1.97959137
116Aplasia/Hypoplasia of the scapulae (HP:0006713)1.97787174
117Hypoplastic scapulae (HP:0000882)1.97787174
118Metaphyseal cupping (HP:0003021)1.96225735
119Prominent nose (HP:0000448)1.95978152
120Pulmonic stenosis (HP:0001642)1.94969660
121Abnormality of skull ossification (HP:0002703)1.94501675
122Neoplasm of the colon (HP:0100273)1.94465119
123Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.94222107
124Abnormality of carpal bone ossification (HP:0006257)1.93261776
125Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.93189943
126Abnormal biliary tract morphology (HP:0012440)1.92976867
127Flat acetabular roof (HP:0003180)1.92816689
128Broad thumb (HP:0011304)1.92546074
129Uterine neoplasm (HP:0010784)1.92382836
130Abnormality of the duodenum (HP:0002246)1.91124599
131Hyperextensible skin (HP:0000974)1.90857156
132Sloping forehead (HP:0000340)1.90712570
133Abnormal ossification of hand bones (HP:0005921)1.90665732
134Broad face (HP:0000283)1.90565589
135Embryonal renal neoplasm (HP:0011794)1.90330921
136Abnormality of the carotid arteries (HP:0005344)1.89842716
137Aplasia/Hypoplasia of the clavicles (HP:0006710)1.89780434
138Coronal craniosynostosis (HP:0004440)1.89296202
139Atresia of the external auditory canal (HP:0000413)1.88894097
140Follicular hyperkeratosis (HP:0007502)1.87567130
141Blue sclerae (HP:0000592)1.87292210
142Cortical dysplasia (HP:0002539)1.87281267
143Angiofibromas (HP:0010615)1.87065036
144Adenoma sebaceum (HP:0009720)1.87065036
145Genu recurvatum (HP:0002816)1.86184676
146Skull defect (HP:0001362)1.86004044
147Cubitus valgus (HP:0002967)1.85946547
148Abnormal umbilical cord blood vessels (HP:0011403)1.85928296
149Single umbilical artery (HP:0001195)1.85928296
150Abnormality of the fetal cardiovascular system (HP:0010948)1.85928296
151Neoplasm of the rectum (HP:0100743)1.85182585
152Squamous cell carcinoma (HP:0002860)1.84636050
153Abnormality of the salivary glands (HP:0010286)1.84522345
154Supernumerary ribs (HP:0005815)1.84051048
155Increased number of teeth (HP:0011069)1.81999278
156Neoplasm of the small intestine (HP:0100833)1.81519887
157Oral leukoplakia (HP:0002745)1.81189134
158Ankyloglossia (HP:0010296)1.81129636
159Deep philtrum (HP:0002002)1.81126420
160Freckling (HP:0001480)1.80604989
161Abnormality of the frontal sinuses (HP:0002687)1.80365934
162Abnormal foot bone ossification (HP:0010675)1.80182574
163Orthostatic hypotension (HP:0001278)1.79714803
164Long eyelashes (HP:0000527)1.78866716
165High pitched voice (HP:0001620)1.77789334
166Ectopia lentis (HP:0001083)1.77288758
167Abnormality of the epiphyses of the hand (HP:0005924)1.76955190
168Abnormality of the phalanges of the hallux (HP:0010057)1.76894077
169Vertebral clefting (HP:0008428)1.76471726
170Spastic diplegia (HP:0001264)1.75992396
171Pseudobulbar signs (HP:0002200)1.75776743
172Hypopigmentation of the fundus (HP:0007894)1.75289371
173Aortic regurgitation (HP:0001659)1.74564654
174Peritonitis (HP:0002586)1.74471838
175Mesomelia (HP:0003027)1.74320271
176* Sandal gap (HP:0001852)1.74304750
177Spinal muscular atrophy (HP:0007269)1.74287400
178Cerebral aneurysm (HP:0004944)1.74176065
179Subacute progressive viral hepatitis (HP:0006572)1.73825900
180Abnormality of oral frenula (HP:0000190)1.73705750
181Exostoses (HP:0100777)1.72907367
182Biconcave vertebral bodies (HP:0004586)1.72041484
183Intestinal polyp (HP:0005266)1.71471832
184Broad palm (HP:0001169)1.71443284
185Mild short stature (HP:0003502)1.71410823
186Narrow palate (HP:0000189)1.69822211
187Delayed cranial suture closure (HP:0000270)1.69389280
188Abnormality involving the epiphyses of the upper limbs (HP:0003839)1.68659023
189Abnormal hand bone ossification (HP:0010660)1.67364988
190Abnormal delivery (HP:0001787)1.67063098
191Disproportionate tall stature (HP:0001519)1.67040352
192Complete atrioventricular canal defect (HP:0001674)1.66857404
193Male infertility (HP:0003251)1.65472937
194Wide anterior fontanel (HP:0000260)1.65374806
195Abnormality of the distal phalanx of the thumb (HP:0009617)1.62003758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.59645424
2CDC74.34174303
3WEE13.66835574
4TTK2.95164889
5NEK92.80002819
6NEK22.73883484
7NEK12.63178369
8LATS12.62261830
9EPHA22.40256478
10RPS6KB22.14927075
11PLK42.13877015
12PRPF4B2.11407536
13EEF2K1.99257895
14LATS21.96142334
15PLK11.92151771
16ACVR1B1.90692270
17BUB11.88600397
18TSSK61.84323504
19PASK1.83613809
20SCYL21.83594914
21BRSK21.79643925
22SRPK11.75304044
23CDK71.64764598
24PKN21.64274791
25CHEK21.63794174
26BRD41.63016987
27PLK31.61050424
28ATR1.59499842
29ERBB31.58589445
30STK38L1.57848389
31STK101.55784633
32MST1R1.54424468
33CHEK11.53603009
34STK381.46877476
35AURKB1.46343904
36MYLK1.46033808
37EIF2AK11.44160017
38CDK41.41798995
39NTRK11.39831143
40MAP3K81.39756297
41MAP3K21.37133484
42STK31.36556979
43BCR1.36294952
44PNCK1.33124437
45PDGFRB1.30319092
46YES11.26485558
47ALK1.25974876
48EPHB21.25419695
49ATM1.25218105
50MAP3K101.20688541
51CDK61.19092602
52CAMK1G1.14687673
53FLT31.13318088
54MTOR1.10248644
55MKNK11.06736765
56* CDK21.03346635
57TGFBR11.03329947
58MELK1.00275787
59PRKG20.95981479
60PAK40.95664697
61AURKA0.92759231
62CAMK1D0.91241113
63TRIB30.90386895
64DYRK30.88737098
65PDK40.88501665
66PDK30.88501665
67SGK30.86157074
68ERBB40.84695398
69PDGFRA0.83824601
70STK40.83080319
71PLK20.82813601
72TESK10.82144373
73JAK10.81832990
74WNK10.79815712
75STK240.79496301
76AKT30.78343099
77CDK10.78242844
78MAP3K120.77823430
79TAOK20.77793337
80RPS6KA40.77183691
81BRSK10.77127402
82MKNK20.75695475
83MET0.74435149
84TRIM280.70738724
85SMG10.70268587
86CSNK1D0.68077067
87PIM10.67413874
88FGFR10.67224645
89ROCK20.67009016
90CSNK1E0.65006267
91CLK10.64547969
92FGFR30.64104993
93MAP3K60.63754539
94TYRO30.63548675
95PRKD20.63384317
96EIF2AK30.63100598
97PRKCI0.61335038
98MAPKAPK30.59711213
99LIMK10.59623501
100TLK10.58640832
101RET0.58301209
102TRPM70.57952770
103TGFBR20.57186259
104MOS0.56474560
105LMTK20.56063350
106CSNK2A20.55164734
107PDK20.55094784
108CDK90.54687845
109PBK0.53837359
110PRKDC0.53188195
111BRAF0.50751165
112ICK0.50460492
113PAK20.49744598
114FGFR40.49733653
115TAF10.49580202
116TESK20.49216108
117PRKD30.47656745
118LRRK20.46896138
119MAPK140.46304980
120BMPR20.46223245
121CDK180.45074763
122RAF10.44297891
123KSR10.43719972
124EPHB10.43243919
125RIPK10.42337138
126DDR20.42225660
127SIK30.41540792
128TTN0.41057435
129KSR20.40847869
130DMPK0.40721829
131CDK140.40656884
132ZAK0.39934920
133CDK150.39433372
134MAPK10.38975559
135AKT20.38912383
136BMX0.38475530
137PAK10.37155262
138WNK30.36968828
139GSK3B0.36153303
140VRK10.36146164
141AKT10.34777312
142CSNK2A10.33412923
143MARK30.32406144
144PTK60.28279694
145RPS6KB10.27957006
146PTK20.27366452
147MAPK100.26839715

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.06630248
2DNA replication_Homo sapiens_hsa030303.96737147
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.93997054
4RNA transport_Homo sapiens_hsa030133.61792945
5Cell cycle_Homo sapiens_hsa041103.22513326
6One carbon pool by folate_Homo sapiens_hsa006703.12389676
7Spliceosome_Homo sapiens_hsa030402.81564005
8Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.75851029
9Homologous recombination_Homo sapiens_hsa034402.55572319
10mRNA surveillance pathway_Homo sapiens_hsa030152.44727923
11Fanconi anemia pathway_Homo sapiens_hsa034602.36293048
12* Nucleotide excision repair_Homo sapiens_hsa034202.30146597
13Base excision repair_Homo sapiens_hsa034102.27301736
14Non-homologous end-joining_Homo sapiens_hsa034502.20018489
15RNA degradation_Homo sapiens_hsa030182.08779608
16RNA polymerase_Homo sapiens_hsa030201.96959613
17Basal transcription factors_Homo sapiens_hsa030221.96640547
18p53 signaling pathway_Homo sapiens_hsa041151.90659998
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.84148796
20* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.73034866
21Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.52134692
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.52121602
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.43981930
24Oocyte meiosis_Homo sapiens_hsa041141.42910633
25Selenocompound metabolism_Homo sapiens_hsa004501.39477809
26MicroRNAs in cancer_Homo sapiens_hsa052061.37432789
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37172268
28Pyrimidine metabolism_Homo sapiens_hsa002401.34251371
29Viral carcinogenesis_Homo sapiens_hsa052031.31618566
30Systemic lupus erythematosus_Homo sapiens_hsa053221.30466812
31Hippo signaling pathway_Homo sapiens_hsa043901.28859536
32Amoebiasis_Homo sapiens_hsa051461.28272775
33Adherens junction_Homo sapiens_hsa045201.28030761
34Glioma_Homo sapiens_hsa052141.24582751
35TGF-beta signaling pathway_Homo sapiens_hsa043501.24205503
36Inositol phosphate metabolism_Homo sapiens_hsa005621.15150484
37Thyroid cancer_Homo sapiens_hsa052161.14059441
38Biosynthesis of amino acids_Homo sapiens_hsa012301.13162607
39Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.08779539
40Gap junction_Homo sapiens_hsa045401.04474001
41ErbB signaling pathway_Homo sapiens_hsa040121.03756754
42mTOR signaling pathway_Homo sapiens_hsa041501.03543782
43N-Glycan biosynthesis_Homo sapiens_hsa005101.03543033
44Lysine degradation_Homo sapiens_hsa003101.00585814
45Basal cell carcinoma_Homo sapiens_hsa052170.98618745
46Neurotrophin signaling pathway_Homo sapiens_hsa047220.98513945
47Epstein-Barr virus infection_Homo sapiens_hsa051690.97201659
48Steroid biosynthesis_Homo sapiens_hsa001000.96114538
49Melanogenesis_Homo sapiens_hsa049160.95286485
50Small cell lung cancer_Homo sapiens_hsa052220.94641587
51HTLV-I infection_Homo sapiens_hsa051660.94610394
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94234507
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.93042277
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.92980099
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.90789968
56Proteasome_Homo sapiens_hsa030500.90507303
57Antigen processing and presentation_Homo sapiens_hsa046120.87330954
58Axon guidance_Homo sapiens_hsa043600.84665977
59Colorectal cancer_Homo sapiens_hsa052100.83971003
60Herpes simplex infection_Homo sapiens_hsa051680.83604381
61Central carbon metabolism in cancer_Homo sapiens_hsa052300.81931363
62Choline metabolism in cancer_Homo sapiens_hsa052310.80939225
63Cysteine and methionine metabolism_Homo sapiens_hsa002700.79261258
64Ribosome_Homo sapiens_hsa030100.79003622
65Prion diseases_Homo sapiens_hsa050200.78260614
66Bladder cancer_Homo sapiens_hsa052190.76305495
67Insulin signaling pathway_Homo sapiens_hsa049100.76174113
68Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75400666
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.74027148
70Tight junction_Homo sapiens_hsa045300.74011939
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.72423503
72Endocytosis_Homo sapiens_hsa041440.72200221
73Estrogen signaling pathway_Homo sapiens_hsa049150.71692666
74Rap1 signaling pathway_Homo sapiens_hsa040150.71010526
75Circadian rhythm_Homo sapiens_hsa047100.71008168
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.70629812
77Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.70106359
78Long-term potentiation_Homo sapiens_hsa047200.69750753
79Vibrio cholerae infection_Homo sapiens_hsa051100.69340411
80Prolactin signaling pathway_Homo sapiens_hsa049170.67414943
81Hedgehog signaling pathway_Homo sapiens_hsa043400.67393970
82Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.67251395
83Notch signaling pathway_Homo sapiens_hsa043300.65718503
84Proteoglycans in cancer_Homo sapiens_hsa052050.64938746
85Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63944380
86Prostate cancer_Homo sapiens_hsa052150.62686733
87Purine metabolism_Homo sapiens_hsa002300.62611308
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.62339880
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62148751
90Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.61950077
91Thyroid hormone signaling pathway_Homo sapiens_hsa049190.61753549
92Dilated cardiomyopathy_Homo sapiens_hsa054140.61556386
93Nitrogen metabolism_Homo sapiens_hsa009100.61408447
94Pentose phosphate pathway_Homo sapiens_hsa000300.61364816
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.60686292
96Platelet activation_Homo sapiens_hsa046110.60681227
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.60098227
98Salmonella infection_Homo sapiens_hsa051320.59729954
99Chronic myeloid leukemia_Homo sapiens_hsa052200.59685299
100Pathways in cancer_Homo sapiens_hsa052000.57248246
101Protein digestion and absorption_Homo sapiens_hsa049740.55712514
102Ras signaling pathway_Homo sapiens_hsa040140.55483440
103Endometrial cancer_Homo sapiens_hsa052130.51551764
104Carbon metabolism_Homo sapiens_hsa012000.51137330
105Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.50952012
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.49916028
107Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.49587487
108VEGF signaling pathway_Homo sapiens_hsa043700.48893807
1092-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.48357269
110Alcoholism_Homo sapiens_hsa050340.47996221
111Hepatitis C_Homo sapiens_hsa051600.47917683
112GnRH signaling pathway_Homo sapiens_hsa049120.47322387
113Wnt signaling pathway_Homo sapiens_hsa043100.46880301
114Vitamin B6 metabolism_Homo sapiens_hsa007500.45884462
115HIF-1 signaling pathway_Homo sapiens_hsa040660.43698149
116FoxO signaling pathway_Homo sapiens_hsa040680.42271081
117Drug metabolism - other enzymes_Homo sapiens_hsa009830.42043571
118Pancreatic cancer_Homo sapiens_hsa052120.41829441
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.39050678
120Focal adhesion_Homo sapiens_hsa045100.38873729
121Non-small cell lung cancer_Homo sapiens_hsa052230.38486409
122Melanoma_Homo sapiens_hsa052180.36198887
123Dorso-ventral axis formation_Homo sapiens_hsa043200.34588898
124Apoptosis_Homo sapiens_hsa042100.33623798
125Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32550639
126AMPK signaling pathway_Homo sapiens_hsa041520.32342288
127Hepatitis B_Homo sapiens_hsa051610.32059654
128Legionellosis_Homo sapiens_hsa051340.31471696
129PI3K-Akt signaling pathway_Homo sapiens_hsa041510.30821823
130Renal cell carcinoma_Homo sapiens_hsa052110.30028824
131ECM-receptor interaction_Homo sapiens_hsa045120.30011500
132Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29023756
133Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.23588331
134Glucagon signaling pathway_Homo sapiens_hsa049220.23521196
135Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22913673
136Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.22797221
137Viral myocarditis_Homo sapiens_hsa054160.22725804
138Shigellosis_Homo sapiens_hsa051310.20773007
139Leukocyte transendothelial migration_Homo sapiens_hsa046700.20223368
140Fructose and mannose metabolism_Homo sapiens_hsa000510.17347991
141Glutathione metabolism_Homo sapiens_hsa004800.15764565
142Acute myeloid leukemia_Homo sapiens_hsa052210.15702484
143Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.15399072

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