CUL5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1purine nucleobase biosynthetic process (GO:0009113)5.07894506
2positive regulation of mitotic sister chromatid separation (GO:1901970)4.91861602
3positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.91861602
4positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.91861602
5regulation of meiosis I (GO:0060631)4.78253624
6centriole replication (GO:0007099)4.66802190
7regulation of DNA methylation (GO:0044030)4.53968193
8viral mRNA export from host cell nucleus (GO:0046784)4.39627868
9nucleobase biosynthetic process (GO:0046112)4.32460348
10mitotic metaphase plate congression (GO:0007080)4.27072049
11protein localization to kinetochore (GO:0034501)4.26152205
12maturation of 5.8S rRNA (GO:0000460)4.03258528
13DNA double-strand break processing (GO:0000729)4.00259059
14protein K6-linked ubiquitination (GO:0085020)3.92821579
15meiotic cell cycle (GO:0051321)3.90787678
16protein localization to chromosome, centromeric region (GO:0071459)3.83259929
17nuclear pore organization (GO:0006999)3.66521826
18ribosome assembly (GO:0042255)3.60785823
19nuclear pore complex assembly (GO:0051292)3.57049989
20ribosome biogenesis (GO:0042254)3.57016707
21retinal cone cell development (GO:0046549)3.56206920
22regulation of female gonad development (GO:2000194)3.44303186
23metaphase plate congression (GO:0051310)3.44297308
24positive regulation of histone H3-K4 methylation (GO:0051571)3.42725035
25piRNA metabolic process (GO:0034587)3.41825397
26muscle filament sliding (GO:0030049)3.41467852
27actin-myosin filament sliding (GO:0033275)3.41467852
28regulation of G0 to G1 transition (GO:0070316)3.39197867
29protein localization to chromosome (GO:0034502)3.37500608
30spindle checkpoint (GO:0031577)3.34702220
31regulation of spindle organization (GO:0090224)3.33258020
32CENP-A containing nucleosome assembly (GO:0034080)3.31692553
33regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27371881
34proteasome assembly (GO:0043248)3.24750468
35negative regulation of DNA-dependent DNA replication (GO:2000104)3.23945920
36cullin deneddylation (GO:0010388)3.23645027
37mitotic spindle checkpoint (GO:0071174)3.22743670
38regulation of acrosome reaction (GO:0060046)3.22542226
39transcription elongation from RNA polymerase I promoter (GO:0006362)3.18915524
40chromatin remodeling at centromere (GO:0031055)3.18611879
41microtubule depolymerization (GO:0007019)3.18180606
42actin-mediated cell contraction (GO:0070252)3.17325639
43replication fork processing (GO:0031297)3.17085774
44inositol phosphate catabolic process (GO:0071545)3.15897948
45melanin metabolic process (GO:0006582)3.15631409
46centriole assembly (GO:0098534)3.14509319
47regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.13663353
487-methylguanosine mRNA capping (GO:0006370)3.13501132
49rRNA modification (GO:0000154)3.11887630
50kinetochore organization (GO:0051383)3.11770795
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.10750687
52negative regulation of sister chromatid segregation (GO:0033046)3.10750687
53negative regulation of mitotic sister chromatid separation (GO:2000816)3.10750687
54negative regulation of mitotic sister chromatid segregation (GO:0033048)3.10750687
55mitotic spindle assembly checkpoint (GO:0007094)3.08999961
56spindle assembly checkpoint (GO:0071173)3.08198738
57regulation of mitotic sister chromatid separation (GO:0010965)3.07446233
58regulation of mitotic sister chromatid segregation (GO:0033047)3.07446233
59regulation of sister chromatid segregation (GO:0033045)3.07446233
60mitotic sister chromatid segregation (GO:0000070)3.04558092
61regulation of mitotic metaphase/anaphase transition (GO:0030071)3.04532791
62negative regulation of chromosome segregation (GO:0051985)3.04313773
637-methylguanosine RNA capping (GO:0009452)3.04157331
64RNA capping (GO:0036260)3.04157331
65DNA methylation involved in gamete generation (GO:0043046)3.04141551
66GMP metabolic process (GO:0046037)3.02906220
67gene silencing by RNA (GO:0031047)3.02888424
68postreplication repair (GO:0006301)3.02643787
69positive regulation of chromosome segregation (GO:0051984)3.02215922
70histone exchange (GO:0043486)3.01327842
71negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.01229422
72establishment of chromosome localization (GO:0051303)3.01173827
73regulation of relaxation of muscle (GO:1901077)3.00745741
74kinetochore assembly (GO:0051382)2.99361141
75transcription elongation from RNA polymerase III promoter (GO:0006385)2.99334360
76termination of RNA polymerase III transcription (GO:0006386)2.99334360
77termination of RNA polymerase I transcription (GO:0006363)2.99125494
78regulation of double-strand break repair via homologous recombination (GO:0010569)2.98879681
79regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.97316766
80regulation of mitotic spindle checkpoint (GO:1903504)2.97093208
81regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.97093208
82DNA replication checkpoint (GO:0000076)2.96435357
83regulation of centrosome cycle (GO:0046605)2.96115523
84oocyte development (GO:0048599)2.95827150
85genitalia morphogenesis (GO:0035112)2.95038905
86regulation of histone H3-K9 methylation (GO:0051570)2.94993422
87transcription from RNA polymerase I promoter (GO:0006360)2.93215318
88pore complex assembly (GO:0046931)2.91942078
89polyol catabolic process (GO:0046174)2.91889539
90mitotic sister chromatid cohesion (GO:0007064)2.91392557
91regulation of chromosome segregation (GO:0051983)2.90969325
92synapsis (GO:0007129)2.90642121
93attachment of spindle microtubules to kinetochore (GO:0008608)2.90353211
94protein deneddylation (GO:0000338)2.90224720
95transcription initiation from RNA polymerase I promoter (GO:0006361)2.88974324
96inositol metabolic process (GO:0006020)2.88800050
97DNA strand renaturation (GO:0000733)2.88373959
98positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.87721735
99female gamete generation (GO:0007292)2.84506832
100inner cell mass cell proliferation (GO:0001833)2.82801488
101histone-serine phosphorylation (GO:0035404)2.81812004
102regulation of mitochondrial translation (GO:0070129)2.80196728
103mitotic chromosome condensation (GO:0007076)2.79570036
104regulation of skeletal muscle contraction (GO:0014819)2.79566225
105sister chromatid segregation (GO:0000819)2.79503980
106sarcoplasmic reticulum calcium ion transport (GO:0070296)2.77070046
107negative regulation of dendrite morphogenesis (GO:0050774)2.76303881
108positive regulation of mitochondrial fission (GO:0090141)2.75727527
109ribonucleoprotein complex disassembly (GO:0032988)2.75348194
110regulation of mitotic spindle organization (GO:0060236)2.74066455
111anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.73694704
112IMP biosynthetic process (GO:0006188)2.73535010
113mitotic G2/M transition checkpoint (GO:0044818)2.72973059
114neural tube formation (GO:0001841)2.72256520
115oocyte maturation (GO:0001556)2.71717557
116monoubiquitinated protein deubiquitination (GO:0035520)2.71586725
117protein prenylation (GO:0018342)2.71329533
118prenylation (GO:0097354)2.71329533
119neuron fate determination (GO:0048664)2.70451111
120negative regulation of DNA recombination (GO:0045910)2.70424123
121resolution of meiotic recombination intermediates (GO:0000712)2.70103304
122regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.69797812
123maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.69581941
124translesion synthesis (GO:0019985)2.69488773
125epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.69259161
126microtubule anchoring (GO:0034453)2.68905314
127regulation of cell maturation (GO:1903429)2.68443219
128DNA replication-dependent nucleosome organization (GO:0034723)2.67493860
129DNA replication-dependent nucleosome assembly (GO:0006335)2.67493860
130regulation of helicase activity (GO:0051095)2.67434998
131nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.65988794
132organelle disassembly (GO:1903008)2.65163980
133centrosome duplication (GO:0051298)2.64953805
134interkinetic nuclear migration (GO:0022027)2.64187454
135regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.64022896
136regulation of DNA endoreduplication (GO:0032875)2.63072590
137DNA replication-independent nucleosome assembly (GO:0006336)2.63009214
138DNA replication-independent nucleosome organization (GO:0034724)2.63009214
139motile cilium assembly (GO:0044458)2.62222144
140phosphorylated carbohydrate dephosphorylation (GO:0046838)2.61723171
141inositol phosphate dephosphorylation (GO:0046855)2.61723171
142positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.61552387
143regulation of spindle checkpoint (GO:0090231)2.61116147
144polyamine biosynthetic process (GO:0006596)2.60440203
145negative regulation of mitosis (GO:0045839)2.60158054
146RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.59226424
147regulation of telomere maintenance via telomerase (GO:0032210)2.59162018
148mRNA export from nucleus (GO:0006406)2.58427607
149primitive streak formation (GO:0090009)2.57764180
150regulation of centriole replication (GO:0046599)2.57452541
151regulation of cell communication by electrical coupling (GO:0010649)2.56127631
152lung-associated mesenchyme development (GO:0060484)2.55772163
153regulation of hexokinase activity (GO:1903299)2.54708065
154regulation of acyl-CoA biosynthetic process (GO:0050812)2.54696279
155somite rostral/caudal axis specification (GO:0032525)2.53367675
156protein K48-linked ubiquitination (GO:0070936)2.52727355
157mitotic G2 DNA damage checkpoint (GO:0007095)2.51893072
158regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.50050033
159histone mRNA metabolic process (GO:0008334)2.49574646
160spermatid nucleus differentiation (GO:0007289)2.47611278
161regulation of steroid hormone secretion (GO:2000831)2.43030557
162regulation of sarcomere organization (GO:0060297)2.41188355

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.44600830
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.28919949
3EZH2_22144423_ChIP-Seq_EOC_Human3.29417342
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.21800311
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.07993828
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.00170613
7SALL1_21062744_ChIP-ChIP_HESCs_Human2.98692886
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.90223141
9E2F4_17652178_ChIP-ChIP_JURKAT_Human2.78781621
10MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.73057785
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.58238147
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.48647261
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44570086
14IGF1R_20145208_ChIP-Seq_DFB_Human2.33580922
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31985590
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.29851112
17ELK1_19687146_ChIP-ChIP_HELA_Human2.20328308
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.20318555
19YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.19558912
20MYC_18555785_ChIP-Seq_MESCs_Mouse2.17397562
21GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.16291034
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15865553
23FOXM1_23109430_ChIP-Seq_U2OS_Human2.10080667
24HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.99694419
25AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.99617660
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.97099873
27FUS_26573619_Chip-Seq_HEK293_Human1.95770787
28MYC_19079543_ChIP-ChIP_MESCs_Mouse1.92785900
29VDR_23849224_ChIP-Seq_CD4+_Human1.88738366
30CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88072717
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87296694
32SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.85652060
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.84480407
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.84133998
35MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83342340
36ZFP57_27257070_Chip-Seq_ESCs_Mouse1.77904856
37GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.75475518
38ZNF274_21170338_ChIP-Seq_K562_Hela1.74942450
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.73677623
40MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.71874175
41GBX2_23144817_ChIP-Seq_PC3_Human1.71769883
42NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.70230852
43PCGF2_27294783_Chip-Seq_ESCs_Mouse1.69451282
44TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.68618791
45* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.67046996
46PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.66775993
47SMAD_19615063_ChIP-ChIP_OVARY_Human1.59456865
48POU5F1_16153702_ChIP-ChIP_HESCs_Human1.59095672
49* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58975999
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58848369
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.57868685
52CBP_20019798_ChIP-Seq_JUKART_Human1.57868685
53AR_21909140_ChIP-Seq_LNCAP_Human1.57264535
54UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.55999146
55PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.55501640
56FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.53529865
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.52050863
58MYC_18358816_ChIP-ChIP_MESCs_Mouse1.50760532
59TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50424032
60NANOG_18555785_ChIP-Seq_MESCs_Mouse1.48840134
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.47918204
62TAF15_26573619_Chip-Seq_HEK293_Human1.45184432
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.44701003
64PIAS1_25552417_ChIP-Seq_VCAP_Human1.44150707
65STAT3_23295773_ChIP-Seq_U87_Human1.41570977
66E2F1_21310950_ChIP-Seq_MCF-7_Human1.40951940
67FOXM1_26456572_ChIP-Seq_MCF-7_Human1.40198076
68EWS_26573619_Chip-Seq_HEK293_Human1.38965260
69PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38880972
70TCF4_23295773_ChIP-Seq_U87_Human1.37620212
71CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34449569
72PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.33304560
73SMAD3_21741376_ChIP-Seq_EPCs_Human1.31254489
74CDX2_19796622_ChIP-Seq_MESCs_Mouse1.30124453
75WT1_19549856_ChIP-ChIP_CCG9911_Human1.29866153
76TP63_19390658_ChIP-ChIP_HaCaT_Human1.29343034
77SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28337909
78* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.26924247
79AR_25329375_ChIP-Seq_VCAP_Human1.25957551
80* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.24022245
81FOXP3_21729870_ChIP-Seq_TREG_Human1.23453766
82ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.22838922
83SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.22822221
84SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22603694
85CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.21843271
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21502204
87YY1_21170310_ChIP-Seq_MESCs_Mouse1.20400189
88EP300_21415370_ChIP-Seq_HL-1_Mouse1.20242448
89SRF_21415370_ChIP-Seq_HL-1_Mouse1.20154875
90GABP_19822575_ChIP-Seq_HepG2_Human1.19552978
91CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17926227
92ELF1_17652178_ChIP-ChIP_JURKAT_Human1.16100428
93CRX_20693478_ChIP-Seq_RETINA_Mouse1.15281842
94POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14741772
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.14457357
96NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.10951266
97NFE2_27457419_Chip-Seq_LIVER_Mouse1.10782401
98HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.10665006
99CTBP2_25329375_ChIP-Seq_LNCAP_Human1.10521373
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.10416516
101* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.10080384
102P53_22387025_ChIP-Seq_ESCs_Mouse1.09493492
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.08886073
104CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.07777748
105ER_23166858_ChIP-Seq_MCF-7_Human1.07705042
106NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.07562989
107FLI1_21867929_ChIP-Seq_TH2_Mouse1.07449394
108TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.07397898
109HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07343555
110IRF1_19129219_ChIP-ChIP_H3396_Human1.07319484
111CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.06783952
112NANOG_18555785_Chip-Seq_ESCs_Mouse1.06708355
113RUNX2_22187159_ChIP-Seq_PCA_Human1.06538504
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05453773
115SALL4_22934838_ChIP-ChIP_CD34+_Human1.03237337
116MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.02194845
117NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.01891880
118NRF2_20460467_ChIP-Seq_MEFs_Mouse1.01891880
119DCP1A_22483619_ChIP-Seq_HELA_Human1.01496400
120CDX2_22108803_ChIP-Seq_LS180_Human1.00618303
121E2F1_18555785_Chip-Seq_ESCs_Mouse1.00198047
122TCF4_22108803_ChIP-Seq_LS180_Human0.99885299
123OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99439912
124* KDM5A_27292631_Chip-Seq_BREAST_Human0.99042999
125NANOG_19829295_ChIP-Seq_ESCs_Human0.98670584
126SOX2_19829295_ChIP-Seq_ESCs_Human0.98670584
127CMYC_18555785_Chip-Seq_ESCs_Mouse0.98598819
128TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.98533728
129POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.98533728
130P300_19829295_ChIP-Seq_ESCs_Human0.98515241
131SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.98170596
132SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98090180
133TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.97968678
134BCAT_22108803_ChIP-Seq_LS180_Human0.97733043
135HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.96646425
136NANOG_21062744_ChIP-ChIP_HESCs_Human0.95832260
137* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95661884
138SOX9_26525672_Chip-Seq_HEART_Mouse0.95658882
139RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.95270257
140SUZ12_18555785_Chip-Seq_ESCs_Mouse0.94860809
141SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.93780447
142RNF2_27304074_Chip-Seq_NSC_Mouse0.91942119
143JUN_21703547_ChIP-Seq_K562_Human0.91221387
144EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.90832469
145EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.90056421
146OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90029291
147PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89828860
148VDR_22108803_ChIP-Seq_LS180_Human0.89757137
149NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.88884768
150SMAD4_21799915_ChIP-Seq_A2780_Human0.87995515
151TTF2_22483619_ChIP-Seq_HELA_Human0.87295097
152CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87263061

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.27712865
2MP0003693_abnormal_embryo_hatching3.15059795
3MP0008058_abnormal_DNA_repair2.98645901
4MP0003123_paternal_imprinting2.95885336
5MP0003111_abnormal_nucleus_morphology2.95570438
6MP0008877_abnormal_DNA_methylation2.93504916
7MP0008789_abnormal_olfactory_epithelium2.80337895
8MP0000372_irregular_coat_pigmentation2.74415659
9MP0005451_abnormal_body_composition2.69881976
10MP0000749_muscle_degeneration2.62470736
11MP0003136_yellow_coat_color2.42496475
12MP0003718_maternal_effect2.28151786
13MP0004270_analgesia2.27297885
14MP0008057_abnormal_DNA_replication2.25292187
15MP0003950_abnormal_plasma_membrane2.22230711
16MP0008007_abnormal_cellular_replicative2.15077252
17MP0010234_abnormal_vibrissa_follicle2.14330401
18MP0005499_abnormal_olfactory_system2.10207845
19MP0005394_taste/olfaction_phenotype2.10207845
20MP0004957_abnormal_blastocyst_morpholog2.09242781
21MP0003077_abnormal_cell_cycle2.07659063
22MP0003787_abnormal_imprinting2.05115847
23MP0002234_abnormal_pharynx_morphology1.97445099
24MP0000569_abnormal_digit_pigmentation1.94573024
25MP0003121_genomic_imprinting1.94437584
26MP0000751_myopathy1.90652882
27MP0003786_premature_aging1.83680406
28MP0004036_abnormal_muscle_relaxation1.82418732
29MP0003646_muscle_fatigue1.81222552
30MP0001986_abnormal_taste_sensitivity1.78584139
31MP0002102_abnormal_ear_morphology1.75296527
32MP0005187_abnormal_penis_morphology1.73352653
33MP0002269_muscular_atrophy1.71537326
34MP0008260_abnormal_autophagy1.71490004
35MP0008932_abnormal_embryonic_tissue1.71268623
36MP0003941_abnormal_skin_development1.62793275
37MP0002876_abnormal_thyroid_physiology1.62701366
38MP0001188_hyperpigmentation1.61059394
39MP0005670_abnormal_white_adipose1.56894965
40MP0009697_abnormal_copulation1.56206049
41MP0002160_abnormal_reproductive_system1.55365859
42MP0005171_absent_coat_pigmentation1.52155572
43MP0002837_dystrophic_cardiac_calcinosis1.48064561
44MP0010678_abnormal_skin_adnexa1.47602369
45MP0002233_abnormal_nose_morphology1.45793505
46MP0004145_abnormal_muscle_electrophysio1.43988888
47MP0005409_darkened_coat_color1.43699479
48MP0005075_abnormal_melanosome_morpholog1.43349029
49MP0003221_abnormal_cardiomyocyte_apopto1.40411004
50MP0005646_abnormal_pituitary_gland1.38430261
51MP0000427_abnormal_hair_cycle1.37590321
52MP0002734_abnormal_mechanical_nocicepti1.34358157
53MP0002735_abnormal_chemical_nociception1.31689266
54MP0006072_abnormal_retinal_apoptosis1.31293089
55MP0001542_abnormal_bone_strength1.31145677
56MP0006292_abnormal_olfactory_placode1.31049630
57MP0005620_abnormal_muscle_contractility1.30676731
58MP0002106_abnormal_muscle_physiology1.28353050
59MP0005389_reproductive_system_phenotype1.27043185
60MP0001529_abnormal_vocalization1.23522491
61MP0002210_abnormal_sex_determination1.23314488
62MP0003937_abnormal_limbs/digits/tail_de1.22537651
63MP0003195_calcinosis1.22238992
64MP0000015_abnormal_ear_pigmentation1.20502214
65MP0001672_abnormal_embryogenesis/_devel1.19672281
66MP0005380_embryogenesis_phenotype1.19672281
67MP0001293_anophthalmia1.18167207
68MP0000759_abnormal_skeletal_muscle1.16852297
69MP0003567_abnormal_fetal_cardiomyocyte1.16323312
70MP0003252_abnormal_bile_duct1.16317589
71MP0004233_abnormal_muscle_weight1.13683013
72MP0004215_abnormal_myocardial_fiber1.12851417
73MP0001177_atelectasis1.11183451
74MP0005369_muscle_phenotype1.10480128
75MP0004087_abnormal_muscle_fiber1.10065511
76MP0003699_abnormal_female_reproductive1.09266323
77MP0001661_extended_life_span1.08759771
78MP0003984_embryonic_growth_retardation1.07216456
79MP0000566_synostosis1.06389595
80MP0005248_abnormal_Harderian_gland1.06357440
81MP0000383_abnormal_hair_follicle1.06344077
82MP0001929_abnormal_gametogenesis1.04077897
83MP0003315_abnormal_perineum_morphology1.03280887
84MP0005266_abnormal_metabolism1.02686759
85MP0009046_muscle_twitch1.02226632
86MP0002088_abnormal_embryonic_growth/wei1.02130183
87MP0001730_embryonic_growth_arrest1.01168180
88MP0000733_abnormal_muscle_development0.99994653
89MP0003755_abnormal_palate_morphology0.99208753
90MP0004084_abnormal_cardiac_muscle0.97951887
91MP0000747_muscle_weakness0.97393515
92MP0002009_preneoplasia0.97324880
93MP0003890_abnormal_embryonic-extraembry0.96538163
94MP0003119_abnormal_digestive_system0.96220282
95MP0001145_abnormal_male_reproductive0.94728030
96MP0005408_hypopigmentation0.94704419
97MP0005253_abnormal_eye_physiology0.93821478
98MP0002972_abnormal_cardiac_muscle0.93098372
99MP0002638_abnormal_pupillary_reflex0.92844162
100MP0002751_abnormal_autonomic_nervous0.92420434
101MP0000750_abnormal_muscle_regeneration0.92018833
102MP0000653_abnormal_sex_gland0.91716275
103MP0002332_abnormal_exercise_endurance0.90988200
104MP0000350_abnormal_cell_proliferation0.90959091
105MP0003880_abnormal_central_pattern0.90624536
106MP0001186_pigmentation_phenotype0.90469406
107MP0006036_abnormal_mitochondrial_physio0.90409775
108MP0000428_abnormal_craniofacial_morphol0.90202598
109MP0000516_abnormal_urinary_system0.90083774
110MP0005367_renal/urinary_system_phenotyp0.90083774
111MP0005647_abnormal_sex_gland0.89096747
112MP0004885_abnormal_endolymph0.88286333
113MP0002108_abnormal_muscle_morphology0.87599833
114MP0010307_abnormal_tumor_latency0.86577294
115MP0006276_abnormal_autonomic_nervous0.86086486
116MP0001697_abnormal_embryo_size0.85102427
117MP0000647_abnormal_sebaceous_gland0.83605708
118MP0002075_abnormal_coat/hair_pigmentati0.82922543
119MP0005330_cardiomyopathy0.82850304
120MP0002084_abnormal_developmental_patter0.82791276
121MP0005645_abnormal_hypothalamus_physiol0.82569012
122MP0000631_abnormal_neuroendocrine_gland0.82414879
123MP0001919_abnormal_reproductive_system0.81823462
124MP0002572_abnormal_emotion/affect_behav0.81556613
125MP0009703_decreased_birth_body0.81439643
126MP0003938_abnormal_ear_development0.81233774
127MP0003698_abnormal_male_reproductive0.80421032
128MP0004484_altered_response_of0.80246177
129MP0005395_other_phenotype0.79398735
130MP0002396_abnormal_hematopoietic_system0.78717388
131MP0002085_abnormal_embryonic_tissue0.78357662
132MP0001299_abnormal_eye_distance/0.78292327
133MP0002063_abnormal_learning/memory/cond0.77667318
134MP0004197_abnormal_fetal_growth/weight/0.77448310
135MP0004142_abnormal_muscle_tone0.77019217
136MP0008995_early_reproductive_senescence0.76323320
137MP0002080_prenatal_lethality0.76319870
138MP0002127_abnormal_cardiovascular_syste0.75830448
139MP0002653_abnormal_ependyma_morphology0.75818479
140MP0001440_abnormal_grooming_behavior0.75674628
141MP0000778_abnormal_nervous_system0.72670994
142MP0009672_abnormal_birth_weight0.72091246
143MP0001984_abnormal_olfaction0.71054908
144MP0003122_maternal_imprinting0.70424488
145MP0001119_abnormal_female_reproductive0.70264613
146MP0009745_abnormal_behavioral_response0.70109235
147MP0010030_abnormal_orbit_morphology0.67205356
148MP0010352_gastrointestinal_tract_polyps0.66999456
149MP0002114_abnormal_axial_skeleton0.65858102
150MP0004859_abnormal_synaptic_plasticity0.65847237
151MP0003635_abnormal_synaptic_transmissio0.65039046
152MP0002089_abnormal_postnatal_growth/wei0.64530448
153MP0004924_abnormal_behavior0.63898514

Predicted human phenotypes

RankGene SetZ-score
1Muscle fiber inclusion bodies (HP:0100299)5.10932616
2Nemaline bodies (HP:0003798)5.09478661
3Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)4.92552370
4Exercise-induced muscle cramps (HP:0003710)4.75683187
5Birth length less than 3rd percentile (HP:0003561)4.02945609
6Abnormality of the labia minora (HP:0012880)3.80340692
7Muscle hypertrophy of the lower extremities (HP:0008968)3.42081184
8Calf muscle hypertrophy (HP:0008981)3.38327302
9Abnormal hair whorl (HP:0010721)3.34990987
10Shoulder girdle muscle weakness (HP:0003547)3.31088317
11Pancreatic fibrosis (HP:0100732)3.12653855
12Abnormality of the left ventricular outflow tract (HP:0011103)3.08623197
13Subaortic stenosis (HP:0001682)3.08623197
14Alopecia of scalp (HP:0002293)3.07221039
15Exercise-induced myalgia (HP:0003738)3.00923484
16Rimmed vacuoles (HP:0003805)2.89573527
17Abnormality of the calf musculature (HP:0001430)2.88906579
18Breast hypoplasia (HP:0003187)2.87334016
19Type 1 muscle fiber predominance (HP:0003803)2.79936531
20Impulsivity (HP:0100710)2.78806673
21Abnormal spermatogenesis (HP:0008669)2.77480105
22Chromosomal breakage induced by crosslinking agents (HP:0003221)2.77375070
23Prostate neoplasm (HP:0100787)2.75403744
24Pelvic girdle muscle weakness (HP:0003749)2.72521068
25Aplasia/Hypoplasia of the fovea (HP:0008060)2.70265081
26Hypoplasia of the fovea (HP:0007750)2.70265081
27Cerebral hypomyelination (HP:0006808)2.67378030
28Distal arthrogryposis (HP:0005684)2.67136403
29Thyroid carcinoma (HP:0002890)2.66460568
30Chromsome breakage (HP:0040012)2.60684816
31Selective tooth agenesis (HP:0001592)2.57752436
32Abnormality of chromosome stability (HP:0003220)2.56270379
33Patellar aplasia (HP:0006443)2.55063451
34Abnormality of the musculature of the pelvis (HP:0001469)2.51997464
35Abnormality of the hip-girdle musculature (HP:0001445)2.51997464
36Volvulus (HP:0002580)2.51982921
37Follicular hyperkeratosis (HP:0007502)2.50621953
38Anterior segment dysgenesis (HP:0007700)2.48574935
39Gonadotropin excess (HP:0000837)2.45517529
40Febrile seizures (HP:0002373)2.45440268
41Aplasia/Hypoplasia of the patella (HP:0006498)2.44436762
42Renal cortical cysts (HP:0000803)2.40472695
43Facial hemangioma (HP:0000329)2.36240697
44Submucous cleft hard palate (HP:0000176)2.34661826
45Abnormality of the fovea (HP:0000493)2.32681088
46Areflexia of lower limbs (HP:0002522)2.27022665
47EMG: myopathic abnormalities (HP:0003458)2.25551589
48Pancreatic cysts (HP:0001737)2.23592084
49Meckel diverticulum (HP:0002245)2.23538863
50Epileptic encephalopathy (HP:0200134)2.21410725
51True hermaphroditism (HP:0010459)2.19934082
52Bundle branch block (HP:0011710)2.17643208
53Azoospermia (HP:0000027)2.17215576
54Proximal amyotrophy (HP:0007126)2.13902606
55Nephroblastoma (Wilms tumor) (HP:0002667)2.13845453
56Neck muscle weakness (HP:0000467)2.12770270
57Embryonal renal neoplasm (HP:0011794)2.12602331
58Focal motor seizures (HP:0011153)2.11960513
59Abnormal auditory evoked potentials (HP:0006958)2.10501852
60Myoglobinuria (HP:0002913)2.09296518
61Methylmalonic acidemia (HP:0002912)2.07757984
62Aplasia/Hypoplasia of the tongue (HP:0010295)2.06670588
63Abnormality of the ileum (HP:0001549)2.05898697
64Abnormality of the preputium (HP:0100587)2.05861977
65Facial cleft (HP:0002006)2.03354267
66Aplasia/Hypoplasia of the tibia (HP:0005772)2.03304710
67Occipital encephalocele (HP:0002085)2.02100792
68Hyporeflexia of lower limbs (HP:0002600)2.00285111
69Rhabdomyosarcoma (HP:0002859)1.99957255
70Medulloblastoma (HP:0002885)1.98372320
71Abnormality of the septum pellucidum (HP:0007375)1.98060069
72Short tibia (HP:0005736)1.97867252
73Medial flaring of the eyebrow (HP:0010747)1.97810050
74Hypoplasia of the capital femoral epiphysis (HP:0003090)1.97564754
75Poor coordination (HP:0002370)1.96329285
76Papillary thyroid carcinoma (HP:0002895)1.94344187
77Pheochromocytoma (HP:0002666)1.94116524
78Abnormality of the columella (HP:0009929)1.93498412
79Abnormality of the renal cortex (HP:0011035)1.93432574
80Absent radius (HP:0003974)1.92942023
81Biliary tract neoplasm (HP:0100574)1.92878012
82Dysautonomia (HP:0002459)1.91264784
83Patent foramen ovale (HP:0001655)1.90880670
84Abnormal lung lobation (HP:0002101)1.90033539
85Rough bone trabeculation (HP:0100670)1.88760345
86Aplasia/Hypoplasia of the uvula (HP:0010293)1.87900892
87Molar tooth sign on MRI (HP:0002419)1.87830254
88Abnormality of midbrain morphology (HP:0002418)1.87830254
89Abnormality of chromosome segregation (HP:0002916)1.86549293
90Short middle phalanx of the 5th finger (HP:0004220)1.86105779
91Bifid tongue (HP:0010297)1.85772408
92Nephrogenic diabetes insipidus (HP:0009806)1.85184035
93Fetal akinesia sequence (HP:0001989)1.84441789
94Congenital primary aphakia (HP:0007707)1.84217585
95Gait imbalance (HP:0002141)1.84044626
96Truncal obesity (HP:0001956)1.83820236
97Irregular epiphyses (HP:0010582)1.83189569
98Abnormality of the anterior horn cell (HP:0006802)1.82916332
99Degeneration of anterior horn cells (HP:0002398)1.82916332
100Colon cancer (HP:0003003)1.82703338
101Abnormality of incisor morphology (HP:0011063)1.82551007
102Short palpebral fissure (HP:0012745)1.82262238
103Genital tract atresia (HP:0001827)1.82191254
104Chronic hepatic failure (HP:0100626)1.81447007
105Oligodactyly (hands) (HP:0001180)1.80419975
106Adrenal hypoplasia (HP:0000835)1.79555924
107Frequent falls (HP:0002359)1.78887459
108Abdominal situs inversus (HP:0003363)1.78587190
109Abnormality of abdominal situs (HP:0011620)1.78587190
110Megaloblastic anemia (HP:0001889)1.78001682
111Absent forearm bone (HP:0003953)1.77751273
112Aplasia involving forearm bones (HP:0009822)1.77751273
113Fair hair (HP:0002286)1.76593678
114Breast aplasia (HP:0100783)1.76216646
115Tubulointerstitial nephritis (HP:0001970)1.75731892
116Capillary hemangiomas (HP:0005306)1.75322872
117Cystic hygroma (HP:0000476)1.74202970
118Median cleft lip (HP:0000161)1.74085885
119Supernumerary spleens (HP:0009799)1.73826091
120Muscle fiber splitting (HP:0003555)1.73588740
121Hip contracture (HP:0003273)1.73442338
122Generalized hypopigmentation of hair (HP:0011358)1.72229480
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.72057328
124Absent septum pellucidum (HP:0001331)1.71127777
125Sloping forehead (HP:0000340)1.71073802
126Bell-shaped thorax (HP:0001591)1.70797325
127Microglossia (HP:0000171)1.70468695
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.69607200
129Small intestinal stenosis (HP:0012848)1.69514411
130Duodenal stenosis (HP:0100867)1.69514411
131Neuroendocrine neoplasm (HP:0100634)1.69231762
132Abnormality of the umbilical cord (HP:0010881)1.69159040
133Abnormality of alanine metabolism (HP:0010916)1.68902834
134Hyperalaninemia (HP:0003348)1.68902834
135Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.68902834
136Absent eyebrow (HP:0002223)1.68647517
137Long clavicles (HP:0000890)1.68646782
138Ureteral duplication (HP:0000073)1.67972083
139Atonic seizures (HP:0010819)1.67610115
140Abnormal finger flexion creases (HP:0006143)1.67321806
141Intestinal atresia (HP:0011100)1.67197905
142Short nail (HP:0001799)1.66863679
143Carpal bone hypoplasia (HP:0001498)1.66761435
144Neoplasm of the small intestine (HP:0100833)1.66641582
145Scotoma (HP:0000575)1.65577869
146Abnormality of the clitoris (HP:0000056)1.65449871
147Hypoplastic left heart (HP:0004383)1.64492484
148Rhabdomyolysis (HP:0003201)1.64365562
149Glucose intolerance (HP:0000833)1.64286018
150Abnormality of the duodenum (HP:0002246)1.64209114
151Abnormal biliary tract morphology (HP:0012440)1.63482429
152Absent phalangeal crease (HP:0006109)1.62805441
153Myotonia (HP:0002486)1.58715166
154Glioma (HP:0009733)1.58414092
155Abnormal biliary tract physiology (HP:0012439)1.57035203
156Bile duct proliferation (HP:0001408)1.57035203
157Muscle stiffness (HP:0003552)1.56721936
158Breast carcinoma (HP:0003002)1.56116917
159Proximal tubulopathy (HP:0000114)1.55995090
160Malignant hyperthermia (HP:0002047)1.54329564

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK27.25039584
2MKNK14.77016446
3AKT33.58339172
4TNIK3.31501207
5TRIM283.13929171
6TSSK63.00720420
7BUB12.94834473
8WEE12.84825299
9CASK2.57512376
10ZAK2.26311768
11TTK2.05718447
12SRPK12.00264144
13PLK31.99322395
14MAP2K71.87378051
15CDC71.78813578
16PLK41.61515760
17PLK21.60175501
18PHKG21.59528144
19PHKG11.59528144
20ERBB31.56812710
21PNCK1.56293097
22CCNB11.55856295
23BRSK21.55119044
24STK38L1.48316095
25NEK91.46975029
26MST41.45823635
27MAP4K21.39022318
28PDK41.37767902
29PDK31.37767902
30STK391.37030414
31PINK11.32745685
32PLK11.32004214
33PBK1.29461585
34CSNK1G11.29079125
35CLK11.20730865
36STK161.19880464
37CDK91.17935257
38SGK21.15023393
39BMPR1B1.14848703
40MAP3K61.12556300
41PRKCG1.12548223
42NEK11.12410587
43FRK1.06054880
44BRAF1.05228174
45CSNK1A1L1.02841217
46EIF2AK11.01834482
47CSNK1G21.00423332
48BRSK11.00067291
49NEK60.99727670
50RAF10.98580620
51CSNK1G30.97660508
52EIF2AK30.96407287
53PIK3CG0.94584300
54KSR10.93439727
55MAP3K120.90071503
56MAP3K40.89906000
57MUSK0.89578042
58STK30.88406609
59BMPR20.88189234
60NUAK10.86899101
61MET0.84616797
62PDK20.83464070
63PRPF4B0.80977507
64ATR0.79113249
65CDK30.78790170
66CHEK20.76738043
67VRK10.75298171
68MAP2K40.74455417
69TRPM70.70543900
70OXSR10.70307419
71MAP3K90.70204962
72TAOK30.69360517
73RPS6KB10.68389051
74PKN10.68213746
75SGK30.67678797
76BCR0.67374511
77EPHA20.66291358
78STK240.65354898
79DMPK0.64560239
80ATM0.64123251
81FER0.63632908
82RPS6KA40.62931846
83EPHA40.62704082
84CHEK10.62280172
85SIK30.61194186
86ACVR1B0.60523536
87TGFBR10.60235659
88SGK2230.60035116
89SGK4940.60035116
90CAMK2A0.59721795
91NEK20.59402201
92AURKA0.59310564
93AURKB0.59084498
94NTRK30.57946839
95WNK30.57742771
96OBSCN0.57626424
97YES10.57433150
98TAF10.57429010
99TTN0.56776957
100PIK3CA0.56236123
101MAPK130.55674129
102EIF2AK20.52813123
103PRKG10.52106068
104CSNK1D0.51374615
105MARK10.50545662
106PRKCI0.48922046
107BRD40.48757179
108CDK10.48313888
109PRKCE0.46464009
110PAK30.45078265
111CDK20.44947239
112ERBB40.44670851
113CSNK2A10.44119302
114MOS0.43805075
115MAP3K130.43217456
116CAMKK20.41677798
117FGFR10.41354873
118CSNK1E0.41137857
119MELK0.39136299
120CSNK1A10.37975447
121MINK10.37916845
122NME10.37627653
123CSNK2A20.36806380
124DYRK1A0.35398215
125LATS10.34578343
126CDK70.33783237
127MAPK100.30012566
128LATS20.29598524
129GSK3B0.28700244
130SGK10.27917440
131MAPK80.23495947
132ARAF0.23026856
133MAPK140.22717567
134PRKDC0.21342423
135CDK80.21249661
136CDK180.20677593
137MAPK70.20229313
138MAP2K30.19274148
139MARK30.19087829

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030084.40436511
2Vitamin B6 metabolism_Homo sapiens_hsa007503.85667557
3RNA polymerase_Homo sapiens_hsa030203.60865771
4RNA transport_Homo sapiens_hsa030133.35304804
5Proteasome_Homo sapiens_hsa030502.97310547
6Propanoate metabolism_Homo sapiens_hsa006402.92618831
7Homologous recombination_Homo sapiens_hsa034402.80422319
8Mismatch repair_Homo sapiens_hsa034302.65952786
9Basal transcription factors_Homo sapiens_hsa030222.62154207
10Cell cycle_Homo sapiens_hsa041102.61036973
11Fanconi anemia pathway_Homo sapiens_hsa034602.39971983
12Spliceosome_Homo sapiens_hsa030402.32261395
13DNA replication_Homo sapiens_hsa030302.17571712
14Regulation of autophagy_Homo sapiens_hsa041402.11662913
15Nucleotide excision repair_Homo sapiens_hsa034201.91996536
16Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90007685
17RNA degradation_Homo sapiens_hsa030181.89529049
18Phototransduction_Homo sapiens_hsa047441.87055900
19Pyrimidine metabolism_Homo sapiens_hsa002401.76940419
20Circadian rhythm_Homo sapiens_hsa047101.72739778
21Oocyte meiosis_Homo sapiens_hsa041141.71855327
22Purine metabolism_Homo sapiens_hsa002301.68879102
23Non-homologous end-joining_Homo sapiens_hsa034501.57778873
24Base excision repair_Homo sapiens_hsa034101.57187477
25p53 signaling pathway_Homo sapiens_hsa041151.57099137
26Nicotine addiction_Homo sapiens_hsa050331.56571830
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.52754688
28mRNA surveillance pathway_Homo sapiens_hsa030151.50506516
29* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49361835
30One carbon pool by folate_Homo sapiens_hsa006701.36005802
31Butanoate metabolism_Homo sapiens_hsa006501.33146806
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32822430
33Pyruvate metabolism_Homo sapiens_hsa006201.32257122
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.28223669
35Synaptic vesicle cycle_Homo sapiens_hsa047211.26611211
36Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24855360
37Collecting duct acid secretion_Homo sapiens_hsa049661.19962404
38Glycerophospholipid metabolism_Homo sapiens_hsa005641.09802087
39Epstein-Barr virus infection_Homo sapiens_hsa051691.05032594
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04836261
41Caffeine metabolism_Homo sapiens_hsa002320.99261614
42Steroid biosynthesis_Homo sapiens_hsa001000.94903123
43Fatty acid elongation_Homo sapiens_hsa000620.94382269
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.94249474
45Dorso-ventral axis formation_Homo sapiens_hsa043200.94057649
46Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.93659598
47Cardiac muscle contraction_Homo sapiens_hsa042600.93170635
48Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92394915
49Cysteine and methionine metabolism_Homo sapiens_hsa002700.82268202
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.81545882
51Fructose and mannose metabolism_Homo sapiens_hsa000510.80519622
52Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.78765153
53Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.74905735
54Amphetamine addiction_Homo sapiens_hsa050310.74207266
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.74157492
56Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.74010517
57Adherens junction_Homo sapiens_hsa045200.73001033
58Taste transduction_Homo sapiens_hsa047420.71727436
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.71289260
60Long-term potentiation_Homo sapiens_hsa047200.70172461
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.69445621
62Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68129251
63mTOR signaling pathway_Homo sapiens_hsa041500.67205830
64Pentose phosphate pathway_Homo sapiens_hsa000300.66978713
65Olfactory transduction_Homo sapiens_hsa047400.66256237
66Ovarian steroidogenesis_Homo sapiens_hsa049130.65855711
67Gap junction_Homo sapiens_hsa045400.63136817
68Parkinsons disease_Homo sapiens_hsa050120.63027252
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.62773259
70Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.62600407
71Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.62369335
72Lysine degradation_Homo sapiens_hsa003100.61078993
73Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60315429
74Long-term depression_Homo sapiens_hsa047300.58595282
75Selenocompound metabolism_Homo sapiens_hsa004500.58278578
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.58197985
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.57550514
78Glucagon signaling pathway_Homo sapiens_hsa049220.55592083
79Circadian entrainment_Homo sapiens_hsa047130.54984805
80Tight junction_Homo sapiens_hsa045300.53983736
81cGMP-PKG signaling pathway_Homo sapiens_hsa040220.53953521
82Peroxisome_Homo sapiens_hsa041460.53835067
83Huntingtons disease_Homo sapiens_hsa050160.52961416
84GABAergic synapse_Homo sapiens_hsa047270.52855382
85Oxytocin signaling pathway_Homo sapiens_hsa049210.52109795
86Melanoma_Homo sapiens_hsa052180.51460584
87TGF-beta signaling pathway_Homo sapiens_hsa043500.50361363
88Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50231564
89Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.49868080
90Vibrio cholerae infection_Homo sapiens_hsa051100.48568323
91Nitrogen metabolism_Homo sapiens_hsa009100.48493802
92beta-Alanine metabolism_Homo sapiens_hsa004100.48291192
93Oxidative phosphorylation_Homo sapiens_hsa001900.47729847
94FoxO signaling pathway_Homo sapiens_hsa040680.47676595
95Fatty acid metabolism_Homo sapiens_hsa012120.47522062
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.47484232
97Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46627413
98HIF-1 signaling pathway_Homo sapiens_hsa040660.46375849
99Biosynthesis of amino acids_Homo sapiens_hsa012300.45617174
100Dilated cardiomyopathy_Homo sapiens_hsa054140.45464444
101Protein export_Homo sapiens_hsa030600.45168325
102ABC transporters_Homo sapiens_hsa020100.45140047
103AMPK signaling pathway_Homo sapiens_hsa041520.44707195
104Autoimmune thyroid disease_Homo sapiens_hsa053200.43384479
105Dopaminergic synapse_Homo sapiens_hsa047280.43070778
106Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.42882357
107Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.42354611
108Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41824989
109Systemic lupus erythematosus_Homo sapiens_hsa053220.41331365
110Primary bile acid biosynthesis_Homo sapiens_hsa001200.40966776
111Inositol phosphate metabolism_Homo sapiens_hsa005620.40427532
112Morphine addiction_Homo sapiens_hsa050320.39603968
113Serotonergic synapse_Homo sapiens_hsa047260.39169404
114Hippo signaling pathway_Homo sapiens_hsa043900.38961457
115Alzheimers disease_Homo sapiens_hsa050100.36294537
116Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.35930621
117Viral carcinogenesis_Homo sapiens_hsa052030.35557744
118Metabolic pathways_Homo sapiens_hsa011000.35400585
119Glutamatergic synapse_Homo sapiens_hsa047240.34564633
120Wnt signaling pathway_Homo sapiens_hsa043100.34278203
121Arginine and proline metabolism_Homo sapiens_hsa003300.34175624
122Longevity regulating pathway - mammal_Homo sapiens_hsa042110.33336930
123Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.31681338
124Insulin signaling pathway_Homo sapiens_hsa049100.31658291
125MicroRNAs in cancer_Homo sapiens_hsa052060.30751394
126Alcoholism_Homo sapiens_hsa050340.30583947
127Phosphatidylinositol signaling system_Homo sapiens_hsa040700.29888227
1282-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.29824139
129Insulin secretion_Homo sapiens_hsa049110.29545727
130Calcium signaling pathway_Homo sapiens_hsa040200.28987519
131Colorectal cancer_Homo sapiens_hsa052100.28167690
132Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27224740
133Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.25990398
134Folate biosynthesis_Homo sapiens_hsa007900.25990185
135Hedgehog signaling pathway_Homo sapiens_hsa043400.25259450
136Phagosome_Homo sapiens_hsa041450.24553250
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23803653
138Sphingolipid metabolism_Homo sapiens_hsa006000.23252937
139MAPK signaling pathway_Homo sapiens_hsa040100.22974824
140Carbon metabolism_Homo sapiens_hsa012000.22864053

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