CUL7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a component of an E3 ubiquitin-protein ligase complex. The encoded protein interacts with TP53, CUL9, and FBXW8 proteins. Defects in this gene are a cause of 3M syndrome type 1 (3M1). Two transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1polarized epithelial cell differentiation (GO:0030859)4.53512156
2paraxial mesoderm development (GO:0048339)4.46989853
3protein retention in ER lumen (GO:0006621)4.35245175
4maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.28110464
5pre-miRNA processing (GO:0031054)4.17574282
6retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.13682207
7planar cell polarity pathway involved in neural tube closure (GO:0090179)4.11972159
8regulation of gene silencing by RNA (GO:0060966)4.02503768
9regulation of posttranscriptional gene silencing (GO:0060147)4.02503768
10regulation of gene silencing by miRNA (GO:0060964)4.02503768
11regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.90964836
12establishment of apical/basal cell polarity (GO:0035089)3.89490153
13protein heterotrimerization (GO:0070208)3.82380955
14hippo signaling (GO:0035329)3.81581905
15semaphorin-plexin signaling pathway (GO:0071526)3.81558966
16regulation of hippo signaling (GO:0035330)3.80954807
17heterochromatin organization (GO:0070828)3.72514471
18skin morphogenesis (GO:0043589)3.52533618
19proline biosynthetic process (GO:0006561)3.47738402
20regulation of translational fidelity (GO:0006450)3.42828708
21establishment or maintenance of monopolar cell polarity (GO:0061339)3.39065189
22establishment of monopolar cell polarity (GO:0061162)3.39065189
23peptidyl-glutamic acid carboxylation (GO:0017187)3.38837102
24protein carboxylation (GO:0018214)3.38837102
25plasma membrane repair (GO:0001778)3.32320823
26regulation of cholesterol homeostasis (GO:2000188)3.27187753
27positive regulation of SMAD protein import into nucleus (GO:0060391)3.25389296
28insulin-like growth factor receptor signaling pathway (GO:0048009)3.24771024
29peptidyl-proline hydroxylation (GO:0019511)3.22381870
30basement membrane organization (GO:0071711)3.19278515
31mannose metabolic process (GO:0006013)3.15923779
32bone trabecula formation (GO:0060346)3.14434784
33DNA unwinding involved in DNA replication (GO:0006268)3.13876054
34regulation of SMAD protein import into nucleus (GO:0060390)3.12047579
35nuclear pore complex assembly (GO:0051292)3.11169218
36nuclear pore organization (GO:0006999)3.10665526
37adherens junction assembly (GO:0034333)3.10337040
38peptidyl-lysine dimethylation (GO:0018027)3.02865177
39glucocorticoid receptor signaling pathway (GO:0042921)2.98625347
40embryonic foregut morphogenesis (GO:0048617)2.96407471
41* activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.96256791
42regulation of cholesterol biosynthetic process (GO:0045540)2.94505450
43epithelial cell-cell adhesion (GO:0090136)2.94414269
44gastrulation with mouth forming second (GO:0001702)2.93093416
45outer ear morphogenesis (GO:0042473)2.92956941
46negative regulation of cell size (GO:0045792)2.89559675
47peptidyl-arginine omega-N-methylation (GO:0035247)2.88450195
48regulation of extracellular matrix disassembly (GO:0010715)2.86822403
49collagen fibril organization (GO:0030199)2.86551549
50cell-cell junction maintenance (GO:0045217)2.86542133
51neuron projection extension involved in neuron projection guidance (GO:1902284)2.84151922
52axon extension involved in axon guidance (GO:0048846)2.84151922
53establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.83237773
54cytoskeletal anchoring at plasma membrane (GO:0007016)2.82676415
55vesicle coating (GO:0006901)2.81610650
56proline metabolic process (GO:0006560)2.80744941
57endocardial cushion development (GO:0003197)2.80445162
58* positive regulation of nuclease activity (GO:0032075)2.78991069
59chromatin assembly (GO:0031497)2.77710971
60negative regulation of fatty acid transport (GO:2000192)2.76649738
61Golgi transport vesicle coating (GO:0048200)2.75223427
62COPI coating of Golgi vesicle (GO:0048205)2.75223427
63negative regulation of fibrinolysis (GO:0051918)2.74807903
64endothelial cell chemotaxis (GO:0035767)2.74332693
65Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.73937808
66cardiac myofibril assembly (GO:0055003)2.73731987
674-hydroxyproline metabolic process (GO:0019471)2.72394908
68negative regulation of chondrocyte differentiation (GO:0032331)2.71196671
69histone H2A monoubiquitination (GO:0035518)2.69159266
70negative regulation of catenin import into nucleus (GO:0035414)2.68965527
71dorsal/ventral axis specification (GO:0009950)2.68698679
72convergent extension (GO:0060026)2.68484851
73lung epithelium development (GO:0060428)2.68055388
74regulation of establishment of planar polarity (GO:0090175)2.67152235
75negative regulation of DNA repair (GO:0045738)2.66561832
76protein localization to kinetochore (GO:0034501)2.66310041
77endodermal cell differentiation (GO:0035987)2.66053456
78dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.65717453
79maternal placenta development (GO:0001893)2.65501467
80regulation of cholesterol metabolic process (GO:0090181)2.65082655
81COPII vesicle coating (GO:0048208)2.64278904
82body morphogenesis (GO:0010171)2.63042584
83glucose 6-phosphate metabolic process (GO:0051156)2.62920691
84regulation of apoptotic cell clearance (GO:2000425)2.62888669
85desmosome organization (GO:0002934)2.62845680
86chondrocyte proliferation (GO:0035988)2.62438988
87positive regulation of hormone biosynthetic process (GO:0046886)2.61268442
88positive regulation of blood vessel endothelial cell migration (GO:0043536)2.58868198
89peptidyl-arginine methylation (GO:0018216)2.57447629
90peptidyl-arginine N-methylation (GO:0035246)2.57447629
91regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57262026
92notochord development (GO:0030903)2.56301751
93negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.55648097
94regulation of plasminogen activation (GO:0010755)2.55433431
95anatomical structure regression (GO:0060033)2.55335071
96regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.54940424
97G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.54565263
98non-canonical Wnt signaling pathway (GO:0035567)2.54413376
99* endoplasmic reticulum unfolded protein response (GO:0030968)2.52320063
100positive regulation of smoothened signaling pathway (GO:0045880)2.51020775
101ectodermal placode formation (GO:0060788)2.50351101
102branching involved in mammary gland duct morphogenesis (GO:0060444)2.49968076
103mRNA stabilization (GO:0048255)2.48057463
104RNA stabilization (GO:0043489)2.48057463
105regulation of heart morphogenesis (GO:2000826)2.47965494
106cell-substrate adherens junction assembly (GO:0007045)2.47659481
107focal adhesion assembly (GO:0048041)2.47659481
108anterior/posterior axis specification, embryo (GO:0008595)2.46772202
109lung-associated mesenchyme development (GO:0060484)2.46642034
110mesenchyme development (GO:0060485)2.46233215
111DNA replication-dependent nucleosome assembly (GO:0006335)2.45394819
112DNA replication-dependent nucleosome organization (GO:0034723)2.45394819
113positive regulation of glycogen biosynthetic process (GO:0045725)2.45219916
114regulation of histone H3-K27 methylation (GO:0061085)2.45192069
115trophectodermal cell differentiation (GO:0001829)2.44931783
116regulation of glucose import in response to insulin stimulus (GO:2001273)2.44891817
117camera-type eye morphogenesis (GO:0048593)2.44833424
118regulation of tight junction assembly (GO:2000810)2.44829770
119heart morphogenesis (GO:0003007)2.44760516
120glomerular basement membrane development (GO:0032836)2.43935554
121NLS-bearing protein import into nucleus (GO:0006607)2.43889629
122dosage compensation (GO:0007549)2.43440383
123atrioventricular valve morphogenesis (GO:0003181)2.43264057
124protein-lipid complex assembly (GO:0065005)2.42268087
125eye morphogenesis (GO:0048592)2.42111480
126positive regulation of hormone metabolic process (GO:0032352)2.41691321
127cochlea morphogenesis (GO:0090103)2.41634337
128negative regulation of cartilage development (GO:0061037)2.41489998
129* regulation of nuclease activity (GO:0032069)2.41368591
130collagen metabolic process (GO:0032963)2.41359459
131cell-substrate junction assembly (GO:0007044)2.41311536
132plasma lipoprotein particle assembly (GO:0034377)2.40853654
133regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.40670275
134* ER-nucleus signaling pathway (GO:0006984)2.40401574
135cell adhesion mediated by integrin (GO:0033627)2.40020392
136protein hydroxylation (GO:0018126)2.39552474
137positive regulation of epithelial to mesenchymal transition (GO:0010718)2.39398266
138folic acid-containing compound biosynthetic process (GO:0009396)2.39396925
139cell migration involved in sprouting angiogenesis (GO:0002042)2.37542667
140hemidesmosome assembly (GO:0031581)2.37405124
141mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.35793732
142apoptotic process involved in morphogenesis (GO:0060561)2.35761575
143barbed-end actin filament capping (GO:0051016)2.35604770
144spliceosomal tri-snRNP complex assembly (GO:0000244)2.35501175
145cell proliferation involved in metanephros development (GO:0072203)2.34998876
146regulation of transforming growth factor beta2 production (GO:0032909)2.34844830
147regulation of catenin import into nucleus (GO:0035412)2.34428658
148intestinal cholesterol absorption (GO:0030299)2.33437973
149vascular endothelial growth factor signaling pathway (GO:0038084)2.33288452
150mitotic nuclear envelope disassembly (GO:0007077)2.32919262
151* cellular response to unfolded protein (GO:0034620)2.32812325
152craniofacial suture morphogenesis (GO:0097094)2.32367308
153very-low-density lipoprotein particle assembly (GO:0034379)2.32255486
154negative regulation of histone methylation (GO:0031061)2.31871869
155regulation of early endosome to late endosome transport (GO:2000641)2.31704557
156cellular response to prostaglandin stimulus (GO:0071379)2.29129060
157multicellular organismal macromolecule metabolic process (GO:0044259)2.26501474
158layer formation in cerebral cortex (GO:0021819)2.26478993
159collagen catabolic process (GO:0030574)2.26448552
160positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.26207733
161embryonic skeletal joint morphogenesis (GO:0060272)2.25763630
162embryonic process involved in female pregnancy (GO:0060136)2.25755087

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.51011338
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.55366920
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.14282798
4THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse3.08464606
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.99181780
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.86349609
7ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.84696318
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.65603567
9ZFP281_18757296_ChIP-ChIP_E14_Mouse2.51061765
10ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.30687218
11MYC_22102868_ChIP-Seq_BL_Human2.24601591
12POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.11600821
13SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.09312432
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.09010978
15CLOCK_20551151_ChIP-Seq_293T_Human2.08820345
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.04630845
17ZFP281_27345836_Chip-Seq_ESCs_Mouse2.04467133
18SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.03933948
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.03608232
20RARG_19884340_ChIP-ChIP_MEFs_Mouse2.01909984
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.00378500
22HIF1A_21447827_ChIP-Seq_MCF-7_Human1.99766878
23* MYC_18555785_ChIP-Seq_MESCs_Mouse1.99000511
24KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.98756799
25KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.98756799
26KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.98756799
27WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.97000743
28EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.96762704
29EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95322871
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.91428943
31MYC_19079543_ChIP-ChIP_MESCs_Mouse1.90885453
32SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.84060032
33PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.82930372
34RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.82569207
35DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.77180442
36ERG_21242973_ChIP-ChIP_JURKAT_Human1.76617219
37KDM2B_26808549_Chip-Seq_DND41_Human1.75287236
38* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.75151201
39ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.74033834
40* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.72792513
41KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72345557
42EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72341364
43TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72010840
44PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.71352599
45TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.68782351
46TP63_19390658_ChIP-ChIP_HaCaT_Human1.67914429
47E2F4_17652178_ChIP-ChIP_JURKAT_Human1.67539683
48KDM2B_26808549_Chip-Seq_SUP-B15_Human1.67271940
49TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.66193809
50HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.60736890
51P300_27058665_Chip-Seq_ZR-75-30cells_Human1.59941589
52ZNF263_19887448_ChIP-Seq_K562_Human1.59900105
53KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.59626617
54* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.57909606
55KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.56184813
56CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.55854273
57ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55780548
58TRIM28_21343339_ChIP-Seq_HEK293_Human1.55723036
59FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.53820883
60CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.53751880
61STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.48929401
62AR_21909140_ChIP-Seq_LNCAP_Human1.48514025
63SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47361784
64SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46859342
65P68_20966046_ChIP-Seq_HELA_Human1.46759130
66ATF3_27146783_Chip-Seq_COLON_Human1.43259753
67RACK7_27058665_Chip-Seq_MCF-7_Human1.42932829
68SMC4_20622854_ChIP-Seq_HELA_Human1.42334067
69RBPJ_22232070_ChIP-Seq_NCS_Mouse1.41542065
70* TET1_21451524_ChIP-Seq_MESCs_Mouse1.41040087
71TCF7_22412390_ChIP-Seq_EML_Mouse1.40948168
72KDM2B_26808549_Chip-Seq_K562_Human1.39980857
73DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38385905
74NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.38166244
75SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37218286
76NANOG_21062744_ChIP-ChIP_HESCs_Human1.37072531
77MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.36310708
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.35946345
79RUNX1_27514584_Chip-Seq_MCF-7_Human1.35844640
80DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34711914
81FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.34110543
82CTCF_27219007_Chip-Seq_ERYTHROID_Human1.33654368
83SALL1_21062744_ChIP-ChIP_HESCs_Human1.33635302
84ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.33627003
85TCF3_18692474_ChIP-Seq_MESCs_Mouse1.33324000
86KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.31292054
87CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30759502
88RXR_22158963_ChIP-Seq_LIVER_Mouse1.29727242
89NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29663889
90TP53_22127205_ChIP-Seq_IMR90_Human1.29564498
91* LXR_22292898_ChIP-Seq_THP-1_Human1.29402645
92STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29367026
93KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.28415054
94KDM2B_26808549_Chip-Seq_JURKAT_Human1.27587309
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.27483620
96ESR1_21235772_ChIP-Seq_MCF-7_Human1.26986113
97SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.26876808
98VDR_21846776_ChIP-Seq_THP-1_Human1.25503757
99* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.24999978
100DNAJC2_21179169_ChIP-ChIP_NT2_Human1.24475421
101TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24439301
102CTCF_27219007_Chip-Seq_Bcells_Human1.23985599
103ISL1_27105846_Chip-Seq_CPCs_Mouse1.23788045
104SA1_27219007_Chip-Seq_ERYTHROID_Human1.23090150
105KLF4_18555785_ChIP-Seq_MESCs_Mouse1.20136857
106POU5F1_16518401_ChIP-PET_MESCs_Mouse1.19408538
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.19252637
108MYC_19030024_ChIP-ChIP_MESCs_Mouse1.19137689
109UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.18798259
110XRN2_22483619_ChIP-Seq_HELA_Human1.18740528
111E2F1_21310950_ChIP-Seq_MCF-7_Human1.18264885
112CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.18218874
113CHD1_26751641_Chip-Seq_LNCaP_Human1.18213677
114FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.18049858
115SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17402545
116* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.17153265
117PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15155628
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.14359608
119CREB1_26743006_Chip-Seq_LNCaP_Human1.13954849
120* TET1_21490601_ChIP-Seq_MESCs_Mouse1.13489143
121NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.13275653
122RARA_24833708_ChIP-Seq_LIVER_Mouse1.12045135
123NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.11807696
124CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10324418
125FOXA2_19822575_ChIP-Seq_HepG2_Human1.10186378
126WT1_19549856_ChIP-ChIP_CCG9911_Human1.08346002
127RARB_24833708_ChIP-Seq_LIVER_Mouse1.07908558
128UBF1/2_26484160_Chip-Seq_HMECs_Human1.06830280
129* FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.06449063
130NFIB_24661679_ChIP-Seq_LUNG_Mouse1.05127386
131* TP53_23651856_ChIP-Seq_MEFs_Mouse1.04495611
132* NCOR1_26117541_ChIP-Seq_K562_Human1.04483125
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.04305752
134NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03110090
135ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.03028599
136TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.02681463
137EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.02637364
138SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.02608481
139MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99432269
140* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.98370993
141NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97826025
142OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97120511
143SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95977095
144SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95792140

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog3.99603086
2MP0008438_abnormal_cutaneous_collagen3.80089981
3MP0003122_maternal_imprinting2.89639661
4MP0010030_abnormal_orbit_morphology2.78313726
5MP0005623_abnormal_meninges_morphology2.73059042
6MP0003123_paternal_imprinting2.71035049
7MP0004272_abnormal_basement_membrane2.65779009
8MP0003283_abnormal_digestive_organ2.39055999
9MP0000537_abnormal_urethra_morphology2.37085308
10MP0000566_synostosis2.35367354
11MP0010352_gastrointestinal_tract_polyps2.26552805
12MP0005058_abnormal_lysosome_morphology2.10604478
13MP0005076_abnormal_cell_differentiation2.10477482
14MP0005275_abnormal_skin_tensile2.08516788
15MP0005409_darkened_coat_color2.06641275
16MP0003121_genomic_imprinting2.06570292
17MP0005503_abnormal_tendon_morphology2.03967852
18MP0003385_abnormal_body_wall1.92188699
19MP0003279_aneurysm1.84571917
20MP0009053_abnormal_anal_canal1.82922596
21MP0009780_abnormal_chondrocyte_physiolo1.82211600
22MP0000733_abnormal_muscle_development1.78785262
23MP0003566_abnormal_cell_adhesion1.75284369
24MP0000428_abnormal_craniofacial_morphol1.74841736
25MP0003119_abnormal_digestive_system1.74191451
26MP0006054_spinal_hemorrhage1.71387367
27* MP0004197_abnormal_fetal_growth/weight/1.70209977
28MP0003567_abnormal_fetal_cardiomyocyte1.66377334
29MP0005451_abnormal_body_composition1.58310122
30MP0002084_abnormal_developmental_patter1.57796586
31MP0004233_abnormal_muscle_weight1.57444332
32MP0005171_absent_coat_pigmentation1.57381606
33MP0003942_abnormal_urinary_system1.57240390
34MP0001849_ear_inflammation1.50888318
35MP0003115_abnormal_respiratory_system1.49746418
36MP0000534_abnormal_ureter_morphology1.47418835
37MP0002877_abnormal_melanocyte_morpholog1.45670851
38MP0004084_abnormal_cardiac_muscle1.44467468
39MP0003172_abnormal_lysosome_physiology1.43826317
40MP0002085_abnormal_embryonic_tissue1.42405974
41MP0005257_abnormal_intraocular_pressure1.41571770
42MP0001730_embryonic_growth_arrest1.39150463
43MP0001672_abnormal_embryogenesis/_devel1.38394611
44MP0005380_embryogenesis_phenotype1.38394611
45MP0002088_abnormal_embryonic_growth/wei1.36439607
46MP0003984_embryonic_growth_retardation1.35933289
47MP0002060_abnormal_skin_morphology1.34908914
48MP0003935_abnormal_craniofacial_develop1.34488534
49MP0002653_abnormal_ependyma_morphology1.33503262
50MP0002932_abnormal_joint_morphology1.32893773
51MP0003329_amyloid_beta_deposits1.32198303
52* MP0002086_abnormal_extraembryonic_tissu1.31700213
53MP0002697_abnormal_eye_size1.30915383
54MP0005508_abnormal_skeleton_morphology1.29634968
55MP0003937_abnormal_limbs/digits/tail_de1.28604043
56MP0001293_anophthalmia1.24808248
57* MP0001697_abnormal_embryo_size1.24435742
58MP0005360_urolithiasis1.24210565
59MP0004957_abnormal_blastocyst_morpholog1.24175322
60MP0001958_emphysema1.22049099
61MP0009840_abnormal_foam_cell1.21875713
62MP0000049_abnormal_middle_ear1.21140667
63MP0001661_extended_life_span1.18037365
64MP0005023_abnormal_wound_healing1.17682390
65MP0000350_abnormal_cell_proliferation1.16908349
66MP0004858_abnormal_nervous_system1.15246321
67* MP0002925_abnormal_cardiovascular_devel1.15217010
68MP0002111_abnormal_tail_morphology1.14542934
69MP0002249_abnormal_larynx_morphology1.14187166
70MP0003755_abnormal_palate_morphology1.13016654
71MP0003111_abnormal_nucleus_morphology1.12571697
72MP0010368_abnormal_lymphatic_system1.12520384
73MP0004264_abnormal_extraembryonic_tissu1.11910686
74MP0002896_abnormal_bone_mineralization1.11258103
75MP0003941_abnormal_skin_development1.10094712
76MP0010630_abnormal_cardiac_muscle1.09064033
77MP0005187_abnormal_penis_morphology1.08728100
78MP0000750_abnormal_muscle_regeneration1.06270698
79MP0008260_abnormal_autophagy1.06241324
80MP0002092_abnormal_eye_morphology1.05818243
81MP0009250_abnormal_appendicular_skeleto1.05618226
82MP0002116_abnormal_craniofacial_bone1.05531772
83MP0009703_decreased_birth_body1.04853321
84MP0000432_abnormal_head_morphology1.04451219
85MP0000003_abnormal_adipose_tissue1.03755098
86* MP0002080_prenatal_lethality1.03746683
87MP0003091_abnormal_cell_migration1.03718237
88MP0003077_abnormal_cell_cycle1.03052452
89MP0001299_abnormal_eye_distance/1.02714566
90MP0005375_adipose_tissue_phenotype1.02683625
91MP0002282_abnormal_trachea_morphology1.02173173
92MP0009672_abnormal_birth_weight1.01671038
93MP0000751_myopathy1.00852022
94MP0001348_abnormal_lacrimal_gland1.00573305
95MP0010234_abnormal_vibrissa_follicle1.00312253
96MP0004133_heterotaxia0.99060729
97MP0000759_abnormal_skeletal_muscle0.99005651
98MP0009384_cardiac_valve_regurgitation0.98630257
99MP0010307_abnormal_tumor_latency0.98605443
100MP0001915_intracranial_hemorrhage0.97261169
101MP0002089_abnormal_postnatal_growth/wei0.96803786
102MP0000678_abnormal_parathyroid_gland0.96749564
103MP0000747_muscle_weakness0.96285366
104MP0004087_abnormal_muscle_fiber0.95902172
105MP0002233_abnormal_nose_morphology0.94961499
106MP0002234_abnormal_pharynx_morphology0.94702966
107MP0003890_abnormal_embryonic-extraembry0.94422666
108MP0000266_abnormal_heart_morphology0.94255188
109MP0009278_abnormal_bone_marrow0.94141080
110MP0000767_abnormal_smooth_muscle0.93482738
111MP0002114_abnormal_axial_skeleton0.91928292
112MP0002108_abnormal_muscle_morphology0.91740992
113MP0004185_abnormal_adipocyte_glucose0.91080401
114MP0005408_hypopigmentation0.90683269
115MP0005083_abnormal_biliary_tract0.89555465
116MP0000516_abnormal_urinary_system0.86545955
117MP0005367_renal/urinary_system_phenotyp0.86545955
118MP0000013_abnormal_adipose_tissue0.85088051
119MP0006138_congestive_heart_failure0.84886816
120MP0005248_abnormal_Harderian_gland0.84098419
121* MP0001614_abnormal_blood_vessel0.83883263
122MP0003453_abnormal_keratinocyte_physiol0.81970038
123MP0000462_abnormal_digestive_system0.80802292
124MP0000762_abnormal_tongue_morphology0.79484325
125MP0005197_abnormal_uvea_morphology0.78923240
126MP0000163_abnormal_cartilage_morphology0.72645612
127MP0001243_abnormal_dermal_layer0.71904086
128MP0005330_cardiomyopathy0.71644702
129MP0005501_abnormal_skin_physiology0.70841786
130MP0000467_abnormal_esophagus_morphology0.69885574
131MP0005666_abnormal_adipose_tissue0.69628667
132MP0002113_abnormal_skeleton_development0.68982984
133* MP0002128_abnormal_blood_circulation0.68360039
134MP0002269_muscular_atrophy0.65744483
135MP0001340_abnormal_eyelid_morphology0.65585759
136MP0001270_distended_abdomen0.64580986
137MP0005369_muscle_phenotype0.64127429

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)5.10313388
2Shallow orbits (HP:0000586)4.08480739
3Premature rupture of membranes (HP:0001788)4.03226536
4Ankle contracture (HP:0006466)3.75742039
5Cerebral aneurysm (HP:0004944)3.45455070
6Short 4th metacarpal (HP:0010044)3.44183926
7Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.44183926
8Renal duplication (HP:0000075)3.36946359
9Bladder diverticulum (HP:0000015)3.30893765
10Hyperacusis (HP:0010780)3.08510343
11Deep venous thrombosis (HP:0002625)3.08154791
12Arterial tortuosity (HP:0005116)2.95705828
13Biconcave vertebral bodies (HP:0004586)2.93953388
14Bowel diverticulosis (HP:0005222)2.88561257
15Abnormality of the 4th metacarpal (HP:0010012)2.86935827
16Vascular tortuosity (HP:0004948)2.85937993
17Flat acetabular roof (HP:0003180)2.85613678
18Broad metatarsal (HP:0001783)2.84156290
19Selective tooth agenesis (HP:0001592)2.68423655
20Vertebral compression fractures (HP:0002953)2.66632832
21Renovascular hypertension (HP:0100817)2.56686515
22Disproportionate tall stature (HP:0001519)2.53917472
23Broad face (HP:0000283)2.52594408
24Mitral valve prolapse (HP:0001634)2.47880509
25Genu recurvatum (HP:0002816)2.47558120
26Cervical subluxation (HP:0003308)2.43440630
27Increased connective tissue (HP:0009025)2.42899710
28Hemorrhage of the eye (HP:0011885)2.37122836
29Elfin facies (HP:0004428)2.34540640
30Deviation of the hallux (HP:0010051)2.32647642
31Type 1 muscle fiber predominance (HP:0003803)2.31509691
32Atrophic scars (HP:0001075)2.31429862
33Thin ribs (HP:0000883)2.31321432
34Lymphangioma (HP:0100764)2.29428981
35Aortic dissection (HP:0002647)2.27974031
36Abnormality of dentin (HP:0010299)2.27343385
37Mildly elevated creatine phosphokinase (HP:0008180)2.26712474
38Flat cornea (HP:0007720)2.26149647
39Wrist flexion contracture (HP:0001239)2.24042828
40Soft skin (HP:0000977)2.23509164
41Enlarged penis (HP:0000040)2.22862629
42Asymmetry of the thorax (HP:0001555)2.22716223
43Hallux valgus (HP:0001822)2.22714791
44Dilatation of the ascending aorta (HP:0005111)2.21977780
45Astrocytoma (HP:0009592)2.20144208
46Abnormality of the astrocytes (HP:0100707)2.20144208
47Nuclear cataract (HP:0100018)2.18944438
48Missing ribs (HP:0000921)2.18570771
49Broad thumb (HP:0011304)2.18351389
50Ependymoma (HP:0002888)2.17038671
51Overriding aorta (HP:0002623)2.16591211
52Upper limb amyotrophy (HP:0009129)2.15968970
53Distal upper limb amyotrophy (HP:0007149)2.15968970
54Short nail (HP:0001799)2.15639568
55Mitral regurgitation (HP:0001653)2.14175104
56Aneurysm (HP:0002617)2.13184755
57Spinal rigidity (HP:0003306)2.12983571
58Ulnar bowing (HP:0003031)2.12611817
59Fragile skin (HP:0001030)2.11109765
60Abnormality of carpal bone ossification (HP:0006257)2.09437474
61Increased nuchal translucency (HP:0010880)2.07375838
62Aortic aneurysm (HP:0004942)2.06599404
63Blue sclerae (HP:0000592)2.05786171
64Buphthalmos (HP:0000557)2.04976521
65Subacute progressive viral hepatitis (HP:0006572)2.04902289
66Insomnia (HP:0100785)2.04636297
67Distal lower limb amyotrophy (HP:0008944)2.03300202
68Neonatal short-limb short stature (HP:0008921)2.02531444
69Hand muscle atrophy (HP:0009130)2.02135410
70Abnormal ossification of hand bones (HP:0005921)1.99087190
71Thin bony cortex (HP:0002753)1.98246630
72Abnormal delivery (HP:0001787)1.97772605
73Broad long bones (HP:0005622)1.96819590
74Cupped ribs (HP:0000887)1.96727002
75Bronchomalacia (HP:0002780)1.94429545
76Increased variability in muscle fiber diameter (HP:0003557)1.93821089
77Advanced eruption of teeth (HP:0006288)1.92768561
78J-shaped sella turcica (HP:0002680)1.92497227
79Natal tooth (HP:0000695)1.91886964
80Broad phalanges of the hand (HP:0009768)1.90501945
81Inguinal hernia (HP:0000023)1.89492688
82Radial bowing (HP:0002986)1.88569028
83Joint stiffness (HP:0001387)1.88396400
84Wormian bones (HP:0002645)1.88304427
85Hepatoblastoma (HP:0002884)1.86774856
86Premature skin wrinkling (HP:0100678)1.85338360
87Abnormal gallbladder physiology (HP:0012438)1.84577339
88Cholecystitis (HP:0001082)1.84577339
89Dislocated radial head (HP:0003083)1.84444701
90Abnormality of the calcaneus (HP:0008364)1.84245679
91Difficulty climbing stairs (HP:0003551)1.84224303
92Deviation of the thumb (HP:0009603)1.84025406
93Broad finger (HP:0001500)1.83621639
94Pterygium (HP:0001059)1.83557371
95Broad phalanx (HP:0006009)1.83269012
96Macroorchidism (HP:0000053)1.82170679
97Achilles tendon contracture (HP:0001771)1.82047205
98Peritonitis (HP:0002586)1.79911461
99Abnormality of the diencephalon (HP:0010662)1.79345576
100Fibroma (HP:0010614)1.79329022
101Coxa vara (HP:0002812)1.78134475
102Abnormality of the Achilles tendon (HP:0005109)1.77428173
103Breech presentation (HP:0001623)1.77299815
104Mesomelia (HP:0003027)1.76820529
105Joint laxity (HP:0001388)1.76754721
106Abnormality of the radial head (HP:0003995)1.75929601
107Long palpebral fissure (HP:0000637)1.75866831
108Ulnar deviation of the wrist (HP:0003049)1.75687969
109Osteoarthritis (HP:0002758)1.75092818
110Elbow flexion contracture (HP:0002987)1.74962050
111Colon cancer (HP:0003003)1.74836525
112Round ear (HP:0100830)1.74791952
113Camptodactyly of toe (HP:0001836)1.74135224
114Hyperextensible skin (HP:0000974)1.73978547
115Broad palm (HP:0001169)1.72848660
116Fibrous tissue neoplasm (HP:0012316)1.72581878
117Flattened epiphyses (HP:0003071)1.72385956
118Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.72127646
119Absent epiphyses (HP:0010577)1.72127646
120Bowing of the arm (HP:0006488)1.71287415
121Bowed forearm bones (HP:0003956)1.71287415
122Atelectasis (HP:0100750)1.70924852
123Mitral stenosis (HP:0001718)1.70615021
124Abnormality of the distal phalanx of the thumb (HP:0009617)1.70596999
125Wide anterior fontanel (HP:0000260)1.70062762
126Pseudobulbar signs (HP:0002200)1.69478088
127Back pain (HP:0003418)1.69109715
128Turricephaly (HP:0000262)1.69086728
129Coronal craniosynostosis (HP:0004440)1.68999449
130Reticulocytosis (HP:0001923)1.68389218
131Stridor (HP:0010307)1.67873084
132Neoplasm of the heart (HP:0100544)1.66970410
133Rectal prolapse (HP:0002035)1.66717809
134Rhizomelia (HP:0008905)1.66519180
135Abnormality of skeletal muscle fiber size (HP:0012084)1.66265693
136Megalocornea (HP:0000485)1.65510754
137Proximal placement of thumb (HP:0009623)1.64692735
138Hypercholesterolemia (HP:0003124)1.64179903
139Abnormality of the acetabulum (HP:0003170)1.62425378
140Exostoses (HP:0100777)1.62380852
141Glioma (HP:0009733)1.59319324
142Broad toe (HP:0001837)1.58857140
143Congenital glaucoma (HP:0001087)1.58325098
144Short phalanx of the thumb (HP:0009660)1.56881100
145Short humerus (HP:0005792)1.56275355
146Abnormality of the peritoneum (HP:0002585)1.56125843
147Skull defect (HP:0001362)1.55967899
148Abnormality of the lower motor neuron (HP:0002366)1.54865500
149Intestinal polyp (HP:0005266)1.54348251

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.35444054
2PKN24.19636098
3CDK123.39821442
4FGFR43.09497752
5MAP3K103.08001582
6EEF2K3.04285470
7PDGFRA2.93459150
8DDR22.56258759
9TTN2.45703520
10LATS22.35360128
11LATS12.34850318
12SMG12.25083470
13RIPK12.21088710
14PTK62.06795070
15ICK1.79256595
16PASK1.76747810
17SCYL21.73854368
18EPHB21.68083066
19PAK41.67609129
20CDC71.65048974
21SIK11.62425534
22MTOR1.60497841
23RPS6KB21.51355383
24NEK11.46387625
25PTK21.43808875
26PAK21.42566791
27NEK21.42500817
28BMX1.40238401
29FLT31.36100758
30PRKD31.28786583
31TGFBR11.27098826
32MET1.24665155
33IRAK31.22396317
34TYRO31.22160333
35FGFR11.21153383
36MST1R1.18990127
37ALK1.18000090
38PRPF4B1.17087246
39LRRK21.16895624
40PRKD21.13612618
41EPHA21.13256008
42MAPK151.09711359
43ERN11.09068833
44FGFR31.08852258
45MAP2K31.04461366
46CAMK1D1.02818952
47ILK1.00205717
48MAP3K61.00063406
49EPHB10.99250681
50CDK70.98866075
51PDGFRB0.98751318
52MAP3K70.96756216
53TTK0.95535318
54FER0.93374175
55BRD40.91064407
56CDK60.89531446
57MAP3K80.84015946
58CDK40.81906937
59SIK20.81643973
60NEK90.80801292
61CAMK1G0.80606089
62PDPK10.80233310
63RET0.79524639
64DMPK0.77251063
65MAP2K60.76614153
66STK30.76171124
67WEE10.75032944
68WNK40.74834389
69WNK10.71049527
70AKT20.71019678
71STK380.69507584
72PAK30.68653114
73CDC42BPA0.64814017
74CHEK10.64161030
75TSSK60.63102606
76MAPK110.58952604
77EPHA30.56162242
78NTRK10.56116969
79PAK60.55983104
80STK100.54145600
81ROCK10.53791892
82PLK10.53486931
83CDK20.52777404
84RPS6KL10.52312525
85RPS6KC10.52312525
86ATR0.49532434
87PIM20.49052114
88LMTK20.48582249
89RPS6KA40.47828716
90TESK20.47568225
91PRKAA10.46654919
92AURKB0.46527518
93ERBB20.46229622
94DYRK1B0.46089354
95PAK10.45706474
96MUSK0.45336626
97FGFR20.45305754
98PRKCI0.43914341
99ARAF0.43800491
100KSR10.43703184
101AKT30.42187572
102CSNK1E0.42166700
103STK38L0.42093901
104ATM0.41749293
105CDK90.41204046
106CDK11A0.40475538
107MARK20.39710738
108AKT10.39422632
109CHEK20.39131946
110PRKDC0.39081082
111CDK150.38740691
112HIPK20.38681669
113MAPK10.38456787
114KSR20.38226818
115CAMKK10.37595455
116PRKD10.37458146
117TRPM70.36845705
118CDK10.36468370
119TGFBR20.36144484
120MAP2K40.36127181
121MAPK80.34875410
122PLK30.34721954
123MAP3K20.34646949
124TAOK10.34532249
125MAPK100.34486932
126LIMK10.34260576
127RPS6KA20.34238476
128MAP2K20.34117581
129KDR0.33976203
130CDK180.33427992
131MKNK10.33153976
132PRKG20.32844687
133DYRK30.32800386
134SRC0.32746379
135TESK10.32165929
136MAP3K10.31738524
137CSNK1D0.31661993
138MAPKAPK30.31654798
139TAOK20.31250208
140UHMK10.31184412
141ROCK20.30791141
142MARK10.30110444
143MOS0.29718204
144RPS6KA60.28658698
145RPS6KB10.28199781
146PDK10.25815590

Predicted pathways (KEGG)

RankGene SetZ-score
1Other glycan degradation_Homo sapiens_hsa005112.61177732
2Basal cell carcinoma_Homo sapiens_hsa052172.55478062
3Hippo signaling pathway_Homo sapiens_hsa043902.33848268
4ECM-receptor interaction_Homo sapiens_hsa045122.28493452
5Glycosaminoglycan degradation_Homo sapiens_hsa005312.28177605
6Hedgehog signaling pathway_Homo sapiens_hsa043402.14565337
7Focal adhesion_Homo sapiens_hsa045102.09284180
8Adherens junction_Homo sapiens_hsa045202.08243639
9Proteoglycans in cancer_Homo sapiens_hsa052051.92014932
10MicroRNAs in cancer_Homo sapiens_hsa052061.83470635
11Fructose and mannose metabolism_Homo sapiens_hsa000511.82455970
12Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.80893987
13Bladder cancer_Homo sapiens_hsa052191.77974109
14Central carbon metabolism in cancer_Homo sapiens_hsa052301.77033146
15Chronic myeloid leukemia_Homo sapiens_hsa052201.76281555
16Small cell lung cancer_Homo sapiens_hsa052221.74898897
17Notch signaling pathway_Homo sapiens_hsa043301.71928666
18Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.68686187
19mTOR signaling pathway_Homo sapiens_hsa041501.67861386
20Cell cycle_Homo sapiens_hsa041101.63913023
21Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.63579682
22RNA transport_Homo sapiens_hsa030131.63008112
23Pentose phosphate pathway_Homo sapiens_hsa000301.60721257
24Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.57631149
25mRNA surveillance pathway_Homo sapiens_hsa030151.57438901
26TGF-beta signaling pathway_Homo sapiens_hsa043501.53496336
27Cyanoamino acid metabolism_Homo sapiens_hsa004601.49728873
28Tight junction_Homo sapiens_hsa045301.49240017
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.47000839
30Dilated cardiomyopathy_Homo sapiens_hsa054141.44125360
31Spliceosome_Homo sapiens_hsa030401.41098436
32Endometrial cancer_Homo sapiens_hsa052131.38007349
33Protein digestion and absorption_Homo sapiens_hsa049741.37618550
34Lysine degradation_Homo sapiens_hsa003101.35554613
35One carbon pool by folate_Homo sapiens_hsa006701.33129553
36Colorectal cancer_Homo sapiens_hsa052101.32797951
37Thyroid cancer_Homo sapiens_hsa052161.32001745
38Wnt signaling pathway_Homo sapiens_hsa043101.26034575
39Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.25677219
40Complement and coagulation cascades_Homo sapiens_hsa046101.24515577
41Thyroid hormone signaling pathway_Homo sapiens_hsa049191.24491808
42Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.24261005
43* Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.21041389
44Steroid biosynthesis_Homo sapiens_hsa001001.20498424
45Pathways in cancer_Homo sapiens_hsa052001.19940381
46Viral carcinogenesis_Homo sapiens_hsa052031.19727740
47Glioma_Homo sapiens_hsa052141.19589791
48Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.18927976
49HTLV-I infection_Homo sapiens_hsa051661.18306094
50AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.17281902
51Amoebiasis_Homo sapiens_hsa051461.17105879
52Viral myocarditis_Homo sapiens_hsa054161.15939112
53DNA replication_Homo sapiens_hsa030301.14476781
54Melanoma_Homo sapiens_hsa052181.13982074
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13297595
56Melanogenesis_Homo sapiens_hsa049161.13179375
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.08639917
58p53 signaling pathway_Homo sapiens_hsa041151.07660732
59Galactose metabolism_Homo sapiens_hsa000521.06642050
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06531416
61Prion diseases_Homo sapiens_hsa050201.05619957
62Prostate cancer_Homo sapiens_hsa052151.02775614
63Estrogen signaling pathway_Homo sapiens_hsa049151.01362977
64Renal cell carcinoma_Homo sapiens_hsa052111.01036722
65Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.00156687
66Non-small cell lung cancer_Homo sapiens_hsa052230.99777131
67AMPK signaling pathway_Homo sapiens_hsa041520.98585469
68Mismatch repair_Homo sapiens_hsa034300.97807648
69Neurotrophin signaling pathway_Homo sapiens_hsa047220.97319204
70Pancreatic cancer_Homo sapiens_hsa052120.94856348
71Longevity regulating pathway - mammal_Homo sapiens_hsa042110.94733135
72Insulin resistance_Homo sapiens_hsa049310.92899755
73Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92638658
74Rap1 signaling pathway_Homo sapiens_hsa040150.90909467
75Oocyte meiosis_Homo sapiens_hsa041140.90321478
76Axon guidance_Homo sapiens_hsa043600.90231124
77HIF-1 signaling pathway_Homo sapiens_hsa040660.89578497
78Carbon metabolism_Homo sapiens_hsa012000.89031055
792-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.88069650
80Insulin signaling pathway_Homo sapiens_hsa049100.87270715
81Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85583223
82Arginine biosynthesis_Homo sapiens_hsa002200.84620221
83Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84336816
84Choline metabolism in cancer_Homo sapiens_hsa052310.83612542
85Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82738727
86Gap junction_Homo sapiens_hsa045400.82094839
87Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80384012
88Systemic lupus erythematosus_Homo sapiens_hsa053220.80224378
89Alcoholism_Homo sapiens_hsa050340.79168015
90Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.78638434
91VEGF signaling pathway_Homo sapiens_hsa043700.78592334
92Thyroid hormone synthesis_Homo sapiens_hsa049180.78564328
93Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76868328
94GnRH signaling pathway_Homo sapiens_hsa049120.76223968
95Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.74793340
96Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.74564136
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.74554813
98Glucagon signaling pathway_Homo sapiens_hsa049220.74453159
99Adipocytokine signaling pathway_Homo sapiens_hsa049200.72916673
100Vibrio cholerae infection_Homo sapiens_hsa051100.71114578
101Transcriptional misregulation in cancer_Homo sapiens_hsa052020.70694040
102Base excision repair_Homo sapiens_hsa034100.70391317
103Inositol phosphate metabolism_Homo sapiens_hsa005620.68726989
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67741798
105Acute myeloid leukemia_Homo sapiens_hsa052210.67450860
106Sulfur relay system_Homo sapiens_hsa041220.67167834
107Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.65395190
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64198913
109Fatty acid biosynthesis_Homo sapiens_hsa000610.63937198
110Nucleotide excision repair_Homo sapiens_hsa034200.63798033
111Type II diabetes mellitus_Homo sapiens_hsa049300.63439654
112Biosynthesis of amino acids_Homo sapiens_hsa012300.62563491
113Phenylalanine metabolism_Homo sapiens_hsa003600.62084587
114Platelet activation_Homo sapiens_hsa046110.60316552
115Fatty acid metabolism_Homo sapiens_hsa012120.59545636
116Dorso-ventral axis formation_Homo sapiens_hsa043200.59477501
117N-Glycan biosynthesis_Homo sapiens_hsa005100.58479755
118Phosphatidylinositol signaling system_Homo sapiens_hsa040700.58073942
119Lysosome_Homo sapiens_hsa041420.56310724
120ErbB signaling pathway_Homo sapiens_hsa040120.56008971
121FoxO signaling pathway_Homo sapiens_hsa040680.55602224
122PPAR signaling pathway_Homo sapiens_hsa033200.55591515
123Aldosterone synthesis and secretion_Homo sapiens_hsa049250.54324240
124cGMP-PKG signaling pathway_Homo sapiens_hsa040220.54309068
125Bile secretion_Homo sapiens_hsa049760.53641914
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.52268119
127Phospholipase D signaling pathway_Homo sapiens_hsa040720.47496542
128Prolactin signaling pathway_Homo sapiens_hsa049170.46463687
129Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45066252
130Endocytosis_Homo sapiens_hsa041440.42551859
131Toxoplasmosis_Homo sapiens_hsa051450.41918415

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