CUX2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)6.47409800
2postsynaptic membrane organization (GO:0001941)5.89811395
3presynaptic membrane organization (GO:0097090)5.71424106
4neuronal action potential propagation (GO:0019227)5.32391992
5pyrimidine nucleobase catabolic process (GO:0006208)5.26946553
6neuron cell-cell adhesion (GO:0007158)5.15410665
7synaptic vesicle maturation (GO:0016188)4.91097592
8endothelium development (GO:0003158)4.85414177
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.67544095
10membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.62536435
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.52470312
12central nervous system myelination (GO:0022010)4.45539390
13axon ensheathment in central nervous system (GO:0032291)4.45539390
14nucleobase catabolic process (GO:0046113)4.28520001
15glutamate secretion (GO:0014047)4.26250466
16vocalization behavior (GO:0071625)4.19522244
17cell migration in hindbrain (GO:0021535)4.11210537
18protein localization to synapse (GO:0035418)4.08338662
19regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.01029972
20righting reflex (GO:0060013)3.99894044
21exploration behavior (GO:0035640)3.87790553
22synaptic vesicle exocytosis (GO:0016079)3.84768731
23cranial nerve morphogenesis (GO:0021602)3.81848611
24regulation of synaptic vesicle exocytosis (GO:2000300)3.81555124
25regulation of pigment cell differentiation (GO:0050932)3.76732306
26regulation of neuronal synaptic plasticity (GO:0048168)3.69181754
27regulation of synapse structural plasticity (GO:0051823)3.67210544
28negative regulation of synaptic transmission, GABAergic (GO:0032229)3.66894472
29ionotropic glutamate receptor signaling pathway (GO:0035235)3.66498530
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.61288070
31regulation of long-term neuronal synaptic plasticity (GO:0048169)3.59411175
32neurotransmitter secretion (GO:0007269)3.56593556
33gamma-aminobutyric acid signaling pathway (GO:0007214)3.54589622
34dendritic spine morphogenesis (GO:0060997)3.54423402
35omega-hydroxylase P450 pathway (GO:0097267)3.49032125
36glutamate receptor signaling pathway (GO:0007215)3.48499775
37regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.45440372
38water-soluble vitamin biosynthetic process (GO:0042364)3.43210885
39regulation of synaptic vesicle transport (GO:1902803)3.42070080
40exogenous drug catabolic process (GO:0042738)3.39009545
41* positive regulation of synapse assembly (GO:0051965)3.38799487
42auditory behavior (GO:0031223)3.38203618
43locomotory exploration behavior (GO:0035641)3.37380031
44amino sugar catabolic process (GO:0046348)3.35442460
45transmission of nerve impulse (GO:0019226)3.34129953
46* positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.28702305
47facial nerve structural organization (GO:0021612)3.24025336
48dendrite morphogenesis (GO:0048813)3.22391319
49neuron recognition (GO:0008038)3.21641683
50drug catabolic process (GO:0042737)3.20839442
51limb bud formation (GO:0060174)3.20507216
52positive regulation of synapse maturation (GO:0090129)3.20181032
53cranial nerve structural organization (GO:0021604)3.19980700
54synaptic vesicle endocytosis (GO:0048488)3.17450408
55startle response (GO:0001964)3.17294585
56layer formation in cerebral cortex (GO:0021819)3.17294172
57membrane depolarization during action potential (GO:0086010)3.11070432
58cerebral cortex radially oriented cell migration (GO:0021799)3.10032441
59G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.09270451
60membrane assembly (GO:0071709)3.08492595
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.06559454
62negative regulation of execution phase of apoptosis (GO:1900118)3.05795508
63L-amino acid import (GO:0043092)3.05189858
64neurotransmitter-gated ion channel clustering (GO:0072578)3.04401886
65* positive regulation of dendritic spine development (GO:0060999)3.02893805
66regulation of synaptic transmission, glutamatergic (GO:0051966)3.01803118
67fear response (GO:0042596)3.01282938
68regulation of glutamate receptor signaling pathway (GO:1900449)3.00856085
69regulation of respiratory system process (GO:0044065)2.96138553
70negative regulation of neurotransmitter transport (GO:0051589)2.95340649
71G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.94687800
72neurotransmitter transport (GO:0006836)2.93290003
73synaptic transmission, glutamatergic (GO:0035249)2.93287531
74aldehyde catabolic process (GO:0046185)2.93147841
75behavioral response to ethanol (GO:0048149)2.92860140
76serotonin metabolic process (GO:0042428)2.92034119
77regulation of respiratory gaseous exchange (GO:0043576)2.91838463
78regulation of neurotransmitter secretion (GO:0046928)2.91359009
79negative regulation of dendrite development (GO:2000171)2.90532658
80behavioral fear response (GO:0001662)2.89688809
81behavioral defense response (GO:0002209)2.89688809
82response to folic acid (GO:0051593)2.89527509
83* regulation of dendritic spine morphogenesis (GO:0061001)2.87993060
84sympathetic nervous system development (GO:0048485)2.87726386
85regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.87572630
86* positive regulation of dendritic spine morphogenesis (GO:0061003)2.87267292
87* membrane depolarization (GO:0051899)2.85398946
88* regulation of synapse assembly (GO:0051963)2.84705386
89negative regulation of neurotransmitter secretion (GO:0046929)2.84394192
90neuron-neuron synaptic transmission (GO:0007270)2.82275363
91mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.81487685
92pattern specification involved in kidney development (GO:0061004)2.81305347
93cardiac ventricle formation (GO:0003211)2.81269935
94positive regulation of amino acid transport (GO:0051957)2.81136737
95long-chain fatty acid biosynthetic process (GO:0042759)2.80454193
96N-acetylneuraminate metabolic process (GO:0006054)2.80450188
97central nervous system neuron axonogenesis (GO:0021955)2.75122727
98regulation of glutamate secretion (GO:0014048)2.75026536
99regulation of synaptic plasticity (GO:0048167)2.74476628
100regulation of axon guidance (GO:1902667)2.74349708
101axon extension (GO:0048675)2.74145031
102neuromuscular process controlling balance (GO:0050885)2.73963449
103negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.73714685
104behavioral response to nicotine (GO:0035095)2.72562163
105establishment of mitochondrion localization (GO:0051654)2.72044202
106amino acid import (GO:0043090)2.71780780
107synapse assembly (GO:0007416)2.71450745
108oxidative demethylation (GO:0070989)2.71172799
109negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.70843390
110positive regulation of protein kinase C signaling (GO:0090037)2.69700746
111behavioral response to cocaine (GO:0048148)2.69455643
112response to auditory stimulus (GO:0010996)2.69255072
113regulation of neurotransmitter transport (GO:0051588)2.69093916
114epithelial cell differentiation involved in kidney development (GO:0035850)2.68940159
115regulation of synaptic transmission, GABAergic (GO:0032228)2.68030201
116developmental pigmentation (GO:0048066)2.67533563
117positive regulation of cellular amine metabolic process (GO:0033240)2.67526257
118erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.65964029
119L-phenylalanine catabolic process (GO:0006559)2.65964029
120positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.65814221
121keratinocyte development (GO:0003334)2.65612223
122organ growth (GO:0035265)2.65362795
123regulation of penile erection (GO:0060405)2.62357093
124regulation of neurotransmitter levels (GO:0001505)2.62162525
125nephron epithelium development (GO:0072009)2.61779586
126* regulation of excitatory postsynaptic membrane potential (GO:0060079)2.61120800
127negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.60689650
128* regulation of dendritic spine development (GO:0060998)2.60633185
129retina layer formation (GO:0010842)2.59875926
130oligodendrocyte differentiation (GO:0048709)2.58745431
131positive regulation of synaptic transmission, GABAergic (GO:0032230)2.58733286
132regulation of vesicle fusion (GO:0031338)2.57642287
133gamma-aminobutyric acid transport (GO:0015812)2.57518463
134* short-term memory (GO:0007614)2.57238434
135reflex (GO:0060004)2.56931064
136positive regulation of meiosis (GO:0045836)2.56404745
137protein heterotetramerization (GO:0051290)2.55979004
138lymphoid progenitor cell differentiation (GO:0002320)2.54661505
139cerebellar granule cell differentiation (GO:0021707)2.54627322
140* positive regulation of membrane potential (GO:0045838)2.53702338
141epithelial cilium movement (GO:0003351)2.53603373
142mechanosensory behavior (GO:0007638)2.52659123
143uronic acid metabolic process (GO:0006063)2.52450122
144glucuronate metabolic process (GO:0019585)2.52450122
145axonal fasciculation (GO:0007413)2.51503317
146negative regulation of protein localization to cell surface (GO:2000009)2.51475470
147central nervous system projection neuron axonogenesis (GO:0021952)2.51203071
148DNA ligation (GO:0006266)2.47983083
149* regulation of postsynaptic membrane potential (GO:0060078)2.47129107
150cilium movement (GO:0003341)2.46883985
151positive regulation of meiotic cell cycle (GO:0051446)2.46707310
152regulation of protein kinase A signaling (GO:0010738)2.46597742
153regulation of short-term neuronal synaptic plasticity (GO:0048172)2.46331621
154adult walking behavior (GO:0007628)2.44501456
155GTP biosynthetic process (GO:0006183)2.42717884
156long-term memory (GO:0007616)2.41124586
157positive regulation of action potential (GO:0045760)2.40571074
158neuron remodeling (GO:0016322)2.40119345
159regulation of timing of cell differentiation (GO:0048505)2.38881249

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.88981067
2GBX2_23144817_ChIP-Seq_PC3_Human3.79398387
3SOX9_22984422_ChIP-ChIP_TESTIS_Rat3.33588704
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.32229217
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.84893955
6TAF15_26573619_Chip-Seq_HEK293_Human2.79510920
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.78493558
8EED_16625203_ChIP-ChIP_MESCs_Mouse2.69835365
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65380198
10EZH2_18974828_ChIP-Seq_MESCs_Mouse2.54493092
11RNF2_18974828_ChIP-Seq_MESCs_Mouse2.54493092
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.54301702
13JARID2_20075857_ChIP-Seq_MESCs_Mouse2.52153792
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.43947755
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43272589
16BMI1_23680149_ChIP-Seq_NPCS_Mouse2.40383016
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.40230620
18ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.36605849
19SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.36548339
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.24789903
21EZH2_27294783_Chip-Seq_ESCs_Mouse2.10034855
22PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.09710533
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.04461325
24* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.01952148
25MTF2_20144788_ChIP-Seq_MESCs_Mouse1.99670858
26IGF1R_20145208_ChIP-Seq_DFB_Human1.97850793
27* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.94965009
28PCGF2_27294783_Chip-Seq_ESCs_Mouse1.94597182
29AR_21572438_ChIP-Seq_LNCaP_Human1.92281962
30CTBP2_25329375_ChIP-Seq_LNCAP_Human1.91794991
31* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.90223570
32FLI1_27457419_Chip-Seq_LIVER_Mouse1.89698605
33RNF2_27304074_Chip-Seq_ESCs_Mouse1.88705604
34CDX2_19796622_ChIP-Seq_MESCs_Mouse1.86305937
35RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.80940244
36RNF2_27304074_Chip-Seq_NSC_Mouse1.74186033
37POU3F2_20337985_ChIP-ChIP_501MEL_Human1.73308171
38RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.67192630
39PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.66978810
40* P300_19829295_ChIP-Seq_ESCs_Human1.65427655
41RARB_27405468_Chip-Seq_BRAIN_Mouse1.63638065
42PIAS1_25552417_ChIP-Seq_VCAP_Human1.63472461
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.61479436
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.61479436
45CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.61148554
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.58154524
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.57144111
48SUZ12_27294783_Chip-Seq_NPCs_Mouse1.52399195
49NANOG_18555785_Chip-Seq_ESCs_Mouse1.51450390
50SMAD3_21741376_ChIP-Seq_EPCs_Human1.50013581
51VDR_22108803_ChIP-Seq_LS180_Human1.48166142
52ZNF274_21170338_ChIP-Seq_K562_Hela1.46118942
53EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.45657836
54* REST_21632747_ChIP-Seq_MESCs_Mouse1.44881630
55SMAD4_21799915_ChIP-Seq_A2780_Human1.44258471
56FUS_26573619_Chip-Seq_HEK293_Human1.42334174
57NFE2_27457419_Chip-Seq_LIVER_Mouse1.40893331
58GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.39278100
59PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38453978
60ER_23166858_ChIP-Seq_MCF-7_Human1.37507117
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.37496365
62TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.37366307
63P53_22387025_ChIP-Seq_ESCs_Mouse1.33815021
64SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.33775428
65E2F1_18555785_Chip-Seq_ESCs_Mouse1.33424394
66EZH2_27294783_Chip-Seq_NPCs_Mouse1.32672772
67TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32570534
68SMAD_19615063_ChIP-ChIP_OVARY_Human1.29526089
69EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.29206353
70SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29115872
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.29058926
72IKZF1_21737484_ChIP-ChIP_HCT116_Human1.29031461
73* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.28546049
74P300_18555785_Chip-Seq_ESCs_Mouse1.28463250
75LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.26575335
76EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.24233195
77CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24216799
78* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.23643363
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.23506548
80CMYC_18555785_Chip-Seq_ESCs_Mouse1.23198704
81UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.22878075
82* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21290586
83NMYC_18555785_Chip-Seq_ESCs_Mouse1.20150355
84MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.20147830
85RUNX1_27457419_Chip-Seq_LIVER_Mouse1.20094007
86* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19897268
87SOX2_21211035_ChIP-Seq_LN229_Gbm1.19481383
88STAT3_18555785_Chip-Seq_ESCs_Mouse1.17482241
89WT1_19549856_ChIP-ChIP_CCG9911_Human1.17108520
90NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.16493548
91SOX2_18555785_Chip-Seq_ESCs_Mouse1.16299315
92* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.16113125
93AR_19668381_ChIP-Seq_PC3_Human1.15823547
94CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.15437002
95RUNX2_22187159_ChIP-Seq_PCA_Human1.14954520
96SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14497386
97EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.12129799
98TP53_18474530_ChIP-ChIP_U2OS_Human1.10681988
99RING1B_27294783_Chip-Seq_ESCs_Mouse1.10426706
100KDM2B_26808549_Chip-Seq_REH_Human1.10001769
101KLF4_18555785_Chip-Seq_ESCs_Mouse1.09593533
102RING1B_27294783_Chip-Seq_NPCs_Mouse1.09153416
103CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.09087406
104NR3C1_23031785_ChIP-Seq_PC12_Mouse1.08515277
105AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.08155440
106WT1_25993318_ChIP-Seq_PODOCYTE_Human1.08074485
107GATA1_26923725_Chip-Seq_HPCs_Mouse1.07695479
108TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07128508
109OCT4_18555785_Chip-Seq_ESCs_Mouse1.06877527
110REST_18959480_ChIP-ChIP_MESCs_Mouse1.06801046
111* TCF4_23295773_ChIP-Seq_U87_Human1.06185487
112E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.05359040
113* DROSHA_22980978_ChIP-Seq_HELA_Human1.04685745
114SOX9_26525672_Chip-Seq_HEART_Mouse1.03338567
115TP53_20018659_ChIP-ChIP_R1E_Mouse1.03325714
116NR3C1_21868756_ChIP-Seq_MCF10A_Human1.02716759
117AR_25329375_ChIP-Seq_VCAP_Human1.01969588
118* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.01334832
119TAL1_26923725_Chip-Seq_HPCs_Mouse1.01288006
120* STAT3_23295773_ChIP-Seq_U87_Human1.00900820
121SMAD1_18555785_Chip-Seq_ESCs_Mouse1.00882721
122ESRRB_18555785_Chip-Seq_ESCs_Mouse1.00514744
123IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.00356279
124CBP_20019798_ChIP-Seq_JUKART_Human1.00356279
125STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.99915248
126MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99502141
127ZFX_18555785_Chip-Seq_ESCs_Mouse0.99278631
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.98212253
129CTCF_18555785_Chip-Seq_ESCs_Mouse0.98204758
130PU1_27457419_Chip-Seq_LIVER_Mouse0.97921968
131P53_22127205_ChIP-Seq_FIBROBLAST_Human0.96906548
132SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96480249
133TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.93712972
134MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.92865036
135* SMAD3_21741376_ChIP-Seq_ESCs_Human0.91524555

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern5.04026926
2MP0003136_yellow_coat_color4.03394527
3MP0009379_abnormal_foot_pigmentation3.95989824
4MP0001188_hyperpigmentation3.80903854
5MP0002822_catalepsy3.55939867
6MP0005409_darkened_coat_color3.35752425
7MP0004270_analgesia2.58512255
8MP0006292_abnormal_olfactory_placode2.51219177
9MP0004381_abnormal_hair_follicle2.49359855
10MP0002102_abnormal_ear_morphology2.42184748
11MP0001486_abnormal_startle_reflex2.39029005
12MP0003635_abnormal_synaptic_transmissio2.36848477
13MP0004859_abnormal_synaptic_plasticity2.34792285
14MP0009046_muscle_twitch2.34774030
15MP0001968_abnormal_touch/_nociception2.29094087
16MP0009745_abnormal_behavioral_response2.25254075
17MP0006276_abnormal_autonomic_nervous2.15213193
18MP0002064_seizures2.07046142
19MP0004742_abnormal_vestibular_system2.05976608
20MP0002272_abnormal_nervous_system2.03058976
21MP0005423_abnormal_somatic_nervous2.01360067
22MP0002734_abnormal_mechanical_nocicepti1.97687420
23MP0004142_abnormal_muscle_tone1.92338105
24MP0000778_abnormal_nervous_system1.89248928
25MP0003724_increased_susceptibility_to1.86127779
26MP0002067_abnormal_sensory_capabilities1.84621751
27MP0003938_abnormal_ear_development1.76767763
28MP0002572_abnormal_emotion/affect_behav1.74648435
29MP0002139_abnormal_hepatobiliary_system1.64889480
30MP0003787_abnormal_imprinting1.64003951
31MP0001986_abnormal_taste_sensitivity1.57918694
32MP0004811_abnormal_neuron_physiology1.57264108
33MP0002557_abnormal_social/conspecific_i1.54861880
34MP0002184_abnormal_innervation1.52343198
35MP0000026_abnormal_inner_ear1.52000005
36MP0001440_abnormal_grooming_behavior1.51987285
37MP0001905_abnormal_dopamine_level1.51772310
38MP0001501_abnormal_sleep_pattern1.50646274
39MP0002063_abnormal_learning/memory/cond1.50200578
40MP0004145_abnormal_muscle_electrophysio1.49266931
41MP0002736_abnormal_nociception_after1.47476292
42MP0002735_abnormal_chemical_nociception1.44304643
43MP0003303_peritoneal_inflammation1.42936903
44MP0005171_absent_coat_pigmentation1.41719602
45MP0000049_abnormal_middle_ear1.41153776
46MP0001970_abnormal_pain_threshold1.40334672
47MP0000015_abnormal_ear_pigmentation1.39914183
48MP0005187_abnormal_penis_morphology1.38140707
49MP0005551_abnormal_eye_electrophysiolog1.37182934
50MP0005085_abnormal_gallbladder_physiolo1.36975911
51MP0001529_abnormal_vocalization1.35647902
52MP0001963_abnormal_hearing_physiology1.35599443
53MP0002751_abnormal_autonomic_nervous1.35241439
54MP0008260_abnormal_autophagy1.33558228
55MP0002876_abnormal_thyroid_physiology1.32723207
56MP0000631_abnormal_neuroendocrine_gland1.32474500
57MP0002733_abnormal_thermal_nociception1.28331795
58MP0000566_synostosis1.27511515
59MP0008569_lethality_at_weaning1.26914250
60MP0002249_abnormal_larynx_morphology1.24411476
61MP0000920_abnormal_myelination1.22974703
62MP0006072_abnormal_retinal_apoptosis1.21582122
63* MP0002752_abnormal_somatic_nervous1.21382036
64MP0003633_abnormal_nervous_system1.17158187
65MP0002234_abnormal_pharynx_morphology1.17094972
66MP0009250_abnormal_appendicular_skeleto1.16888464
67MP0005174_abnormal_tail_pigmentation1.15813973
68MP0002177_abnormal_outer_ear1.15159829
69* MP0002882_abnormal_neuron_morphology1.12779524
70MP0002638_abnormal_pupillary_reflex1.10325514
71MP0001661_extended_life_span1.09386268
72MP0003879_abnormal_hair_cell1.08932911
73MP0001485_abnormal_pinna_reflex1.08785217
74MP0008875_abnormal_xenobiotic_pharmacok1.07531677
75MP0000569_abnormal_digit_pigmentation1.05332346
76* MP0003861_abnormal_nervous_system1.05251984
77MP0003631_nervous_system_phenotype1.03028980
78MP0005379_endocrine/exocrine_gland_phen1.01718101
79MP0003890_abnormal_embryonic-extraembry1.01494028
80MP0002229_neurodegeneration1.00878017
81MP0002066_abnormal_motor_capabilities/c1.00322829
82MP0000372_irregular_coat_pigmentation0.99512285
83MP0004272_abnormal_basement_membrane0.99241480
84MP0005595_abnormal_vascular_smooth0.97824086
85MP0003283_abnormal_digestive_organ0.96611133
86MP0001177_atelectasis0.96589923
87MP0003119_abnormal_digestive_system0.94546478
88MP0003329_amyloid_beta_deposits0.94333006
89MP0002069_abnormal_eating/drinking_beha0.93825938
90MP0002277_abnormal_respiratory_mucosa0.92843725
91* MP0000955_abnormal_spinal_cord0.91998189
92MP0004885_abnormal_endolymph0.91130969
93MP0000534_abnormal_ureter_morphology0.90863235
94MP0003121_genomic_imprinting0.89384824
95MP0003315_abnormal_perineum_morphology0.89127857
96MP0010386_abnormal_urinary_bladder0.87968740
97MP0005394_taste/olfaction_phenotype0.87258658
98MP0005499_abnormal_olfactory_system0.87258658
99MP0001664_abnormal_digestion0.86433690
100MP0001299_abnormal_eye_distance/0.84807626
101MP0000537_abnormal_urethra_morphology0.84607717
102MP0001502_abnormal_circadian_rhythm0.83593728
103MP0001984_abnormal_olfaction0.83012102
104MP0005386_behavior/neurological_phenoty0.82680770
105MP0004924_abnormal_behavior0.82680770
106MP0003718_maternal_effect0.81595466
107MP0003937_abnormal_limbs/digits/tail_de0.80994659
108MP0002653_abnormal_ependyma_morphology0.80527755
109MP0004133_heterotaxia0.80327985
110MP0002909_abnormal_adrenal_gland0.79624891
111* MP0002152_abnormal_brain_morphology0.79576065
112MP0003385_abnormal_body_wall0.78933786
113MP0005253_abnormal_eye_physiology0.77494718
114MP0003195_calcinosis0.77331481
115MP0003828_pulmonary_edema0.77292763
116MP0003942_abnormal_urinary_system0.77149364
117MP0005365_abnormal_bile_salt0.76245828
118MP0003122_maternal_imprinting0.75170349
119MP0000681_abnormal_thyroid_gland0.74534725
120MP0005248_abnormal_Harderian_gland0.73919595
121MP0003632_abnormal_nervous_system0.73526541
122MP0002082_postnatal_lethality0.73286435
123MP0010770_preweaning_lethality0.73286435
124MP0005646_abnormal_pituitary_gland0.72871965
125MP0003868_abnormal_feces_composition0.72429587
126MP0005645_abnormal_hypothalamus_physiol0.71903156
127MP0005451_abnormal_body_composition0.71495060
128MP0002938_white_spotting0.69988448
129MP0010769_abnormal_survival0.69617062
130MP0008872_abnormal_physiological_respon0.69109923
131MP0008789_abnormal_olfactory_epithelium0.68757878
132MP0005195_abnormal_posterior_eye0.68325453
133MP0005623_abnormal_meninges_morphology0.64994992
134MP0002233_abnormal_nose_morphology0.63480032
135MP0001346_abnormal_lacrimal_gland0.63170183
136MP0008995_early_reproductive_senescence0.63035366
137MP0002163_abnormal_gland_morphology0.62628754

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.12649045
2Nonprogressive disorder (HP:0003680)3.76771252
3Peripheral hypomyelination (HP:0007182)3.69196459
4Absent/shortened dynein arms (HP:0200106)3.55774270
5Dynein arm defect of respiratory motile cilia (HP:0012255)3.55774270
6Concave nail (HP:0001598)3.47891688
7Ulnar claw (HP:0001178)3.45669375
8Limb dystonia (HP:0002451)3.44378955
9Abnormality of secondary sexual hair (HP:0009888)3.40061021
10Abnormality of the axillary hair (HP:0100134)3.40061021
11Action tremor (HP:0002345)3.33483355
12Progressive inability to walk (HP:0002505)3.24476310
13Abnormal ciliary motility (HP:0012262)3.20208814
14Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.15254529
15Parakeratosis (HP:0001036)3.14614389
16Broad-based gait (HP:0002136)3.09661689
17Atonic seizures (HP:0010819)2.98350482
18Febrile seizures (HP:0002373)2.95137030
19Optic disc pallor (HP:0000543)2.85813681
20Sensory axonal neuropathy (HP:0003390)2.81522599
21Agitation (HP:0000713)2.77937913
22Abnormal respiratory epithelium morphology (HP:0012253)2.76648441
23Abnormal respiratory motile cilium morphology (HP:0005938)2.76648441
24Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.74759588
25Abnormal respiratory motile cilium physiology (HP:0012261)2.73058507
26Poor eye contact (HP:0000817)2.72312606
27Attenuation of retinal blood vessels (HP:0007843)2.70576106
28Focal seizures (HP:0007359)2.68578613
29Thyroid-stimulating hormone excess (HP:0002925)2.65108587
30Thickened helices (HP:0000391)2.64904813
31Status epilepticus (HP:0002133)2.63397334
32Increased hepatocellular lipid droplets (HP:0006565)2.63194454
33Amblyopia (HP:0000646)2.61890350
34Renal Fanconi syndrome (HP:0001994)2.58411900
35Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.58088274
36Epileptiform EEG discharges (HP:0011182)2.55681204
37Hyperventilation (HP:0002883)2.54880403
38Inability to walk (HP:0002540)2.49843323
39Synostosis involving the elbow (HP:0003938)2.49275547
40Humeroradial synostosis (HP:0003041)2.49275547
41Epileptic encephalopathy (HP:0200134)2.48616232
42Absent speech (HP:0001344)2.48526088
43Impaired social interactions (HP:0000735)2.44132355
44Abnormal social behavior (HP:0012433)2.44132355
45Steppage gait (HP:0003376)2.42464188
46Exotropia (HP:0000577)2.42125606
47Gaze-evoked nystagmus (HP:0000640)2.41721045
48Hypothermia (HP:0002045)2.41260189
49Megalencephaly (HP:0001355)2.40334087
50Progressive cerebellar ataxia (HP:0002073)2.38952516
51Hepatoblastoma (HP:0002884)2.38853996
52Torticollis (HP:0000473)2.38213338
53Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.36587027
54Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.36013977
55EEG with generalized epileptiform discharges (HP:0011198)2.35837761
56Prolonged partial thromboplastin time (HP:0003645)2.34879700
57Hypsarrhythmia (HP:0002521)2.33921684
58Aplasia/hypoplasia of the uterus (HP:0008684)2.32843884
59Absent rod-and cone-mediated responses on ERG (HP:0007688)2.32486363
60Impaired vibration sensation in the lower limbs (HP:0002166)2.31447335
61Cutaneous finger syndactyly (HP:0010554)2.30209448
62Upper limb muscle weakness (HP:0003484)2.28029834
63Deep venous thrombosis (HP:0002625)2.26812874
64Polyphagia (HP:0002591)2.25656484
65Abnormality of monocarboxylic acid metabolism (HP:0010996)2.25030532
66Split foot (HP:0001839)2.23712261
67Decreased central vision (HP:0007663)2.21827653
68Fair hair (HP:0002286)2.18773195
69Abnormal eating behavior (HP:0100738)2.18499759
70Supranuclear gaze palsy (HP:0000605)2.18280563
71Gait imbalance (HP:0002141)2.18086105
72Sleep apnea (HP:0010535)2.17560087
73Dialeptic seizures (HP:0011146)2.17095532
74Abnormality of aromatic amino acid family metabolism (HP:0004338)2.15836257
75Stage 5 chronic kidney disease (HP:0003774)2.15598095
76Retinal dysplasia (HP:0007973)2.13965207
77Neurofibrillary tangles (HP:0002185)2.13408153
78Atelectasis (HP:0100750)2.11419969
79Restlessness (HP:0000711)2.10984241
80Dry hair (HP:0011359)2.10263597
81Myokymia (HP:0002411)2.09708177
82Esotropia (HP:0000565)2.09701818
83Intellectual disability, severe (HP:0010864)2.09125953
84Absence seizures (HP:0002121)2.08793193
85Optic nerve hypoplasia (HP:0000609)2.08278940
86Complement deficiency (HP:0004431)2.06780595
87Ankle clonus (HP:0011448)2.06696025
88Type I transferrin isoform profile (HP:0003642)2.06300426
89Protruding tongue (HP:0010808)2.05410646
90Congenital sensorineural hearing impairment (HP:0008527)2.05359644
91Drooling (HP:0002307)2.05106427
92Excessive salivation (HP:0003781)2.05106427
93Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.00475304
94Degeneration of the lateral corticospinal tracts (HP:0002314)2.00475304
95Hypophosphatemic rickets (HP:0004912)1.99954443
96Abnormal sex determination (HP:0012244)1.99301806
97Sex reversal (HP:0012245)1.99301806
98Lipid accumulation in hepatocytes (HP:0006561)1.99107338
99Abnormality of the septum pellucidum (HP:0007375)1.97983839
100Urinary bladder sphincter dysfunction (HP:0002839)1.97286255
101Cortical dysplasia (HP:0002539)1.96325760
102Cutaneous syndactyly (HP:0012725)1.96203440
103Hyperglycinemia (HP:0002154)1.96057133
104Decreased number of peripheral myelinated nerve fibers (HP:0003380)1.95815650
105Metabolic alkalosis (HP:0200114)1.95773766
106Alacrima (HP:0000522)1.94297506
107Generalized tonic-clonic seizures (HP:0002069)1.93303515
108Muscle hypertrophy of the lower extremities (HP:0008968)1.93035423
109Flat occiput (HP:0005469)1.92941343
110Fibular aplasia (HP:0002990)1.92321988
111Obstructive sleep apnea (HP:0002870)1.92279886
112Shawl scrotum (HP:0000049)1.92274631
113Hemiparesis (HP:0001269)1.92024183
114Abnormality of binocular vision (HP:0011514)1.91844057
115Diplopia (HP:0000651)1.91844057
116Septo-optic dysplasia (HP:0100842)1.91680656
117Genital tract atresia (HP:0001827)1.91651788
118Bronchomalacia (HP:0002780)1.91591129
119Nephronophthisis (HP:0000090)1.91231513
120Absent septum pellucidum (HP:0001331)1.90716304
121Truncal ataxia (HP:0002078)1.90145244
122Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89908082
123Spastic gait (HP:0002064)1.88705811
124Acute necrotizing encephalopathy (HP:0006965)1.88645652
125Amyotrophic lateral sclerosis (HP:0007354)1.87606095
126Hypomagnesemia (HP:0002917)1.87476099
127Glomerulonephritis (HP:0000099)1.87378991
128Abnormality of salivation (HP:0100755)1.87210890
129Abnormality of the lower motor neuron (HP:0002366)1.86254891
130Abnormality of magnesium homeostasis (HP:0004921)1.85517700
131Prolonged QT interval (HP:0001657)1.85126854
132Mitochondrial inheritance (HP:0001427)1.85072160
133Vaginal atresia (HP:0000148)1.83537704
134Onion bulb formation (HP:0003383)1.83476025
135Nasolacrimal duct obstruction (HP:0000579)1.81499351
136Volvulus (HP:0002580)1.80316616
137Cupped ear (HP:0000378)1.79998073
1383-Methylglutaconic aciduria (HP:0003535)1.79981921
139Hyperthyroidism (HP:0000836)1.78638823
140Mutism (HP:0002300)1.78574618
141Microvesicular hepatic steatosis (HP:0001414)1.78322150
142Urinary urgency (HP:0000012)1.78261563
143Preaxial foot polydactyly (HP:0001841)1.77802694
144Abnormality of renal resorption (HP:0011038)1.77697874
145Stereotypic behavior (HP:0000733)1.77300020
146Coronal craniosynostosis (HP:0004440)1.77298126
147Dysmetria (HP:0001310)1.77189071
148Anhidrosis (HP:0000970)1.76762741
149Male pseudohermaphroditism (HP:0000037)1.76752416
150Short 4th metacarpal (HP:0010044)1.76706590
151Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.76706590
152Progressive external ophthalmoplegia (HP:0000590)1.76703500
153Midline defect of the nose (HP:0004122)1.76502304
154Bradycardia (HP:0001662)1.75780425
155Focal dystonia (HP:0004373)1.74839474
156Pachygyria (HP:0001302)1.73705546
157Abnormality of the renal medulla (HP:0100957)1.73630786
158Abnormality of dental color (HP:0011073)1.72420425
159Reduced antithrombin III activity (HP:0001976)1.71190309
160Morphological abnormality of the pyramidal tract (HP:0002062)1.71041212
161Adrenal hypoplasia (HP:0000835)1.70569545
162Hyperlipoproteinemia (HP:0010980)1.69605108
163Aplasia involving bones of the upper limbs (HP:0009823)1.68741529
164Aplasia of the phalanges of the hand (HP:0009802)1.68741529
165Aplasia involving bones of the extremities (HP:0009825)1.68741529
166Incomplete penetrance (HP:0003829)1.67724588
167Conical tooth (HP:0000698)1.65944582
168Postural instability (HP:0002172)1.65737653
169Autism (HP:0000717)1.65181273
170Specific learning disability (HP:0001328)1.65056041
171Gastroesophageal reflux (HP:0002020)1.63792698
172Widely spaced teeth (HP:0000687)1.63503068
173Dysdiadochokinesis (HP:0002075)1.63362101
174Long nose (HP:0003189)1.62297476
175Abnormality of the labia minora (HP:0012880)1.62196646
176Bifid scrotum (HP:0000048)1.62141322
177Hypoplasia of the corpus callosum (HP:0002079)1.61964499

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK6.79267056
2TNIK4.32162001
3MKNK23.36258616
4MUSK3.09844824
5FES3.07453313
6TLK12.91710783
7STK162.54704147
8NEK12.38071130
9STK392.20717730
10DAPK22.12177192
11MAP2K71.82740970
12MKNK11.76807154
13NTRK31.75245639
14PNCK1.73794632
15MAPK131.73768379
16TYRO31.73611263
17PRPF4B1.69268632
18EPHA41.67216605
19FGR1.65719968
20OXSR11.63407141
21LATS21.60977578
22CAMK1G1.57148658
23PAK61.53091415
24FER1.50671037
25SRPK11.48487181
26BLK1.47153778
27WNK31.44040997
28CAMKK11.41279928
29CCNB11.38386271
30CDK191.37098774
31WNK11.36132243
32PRKD31.35225027
33CAMK2B1.30143323
34CAMK1D1.29066242
35GRK11.28271076
36BMPR1B1.26085882
37MARK11.18794867
38GRK71.13195211
39MAP3K91.12696999
40UHMK11.11698409
41FRK1.11581075
42PKN11.09880644
43IRAK21.09832922
44EIF2AK21.07512266
45NME21.04788412
46CAMK41.02187237
47NEK61.02082571
48MAP3K121.01955937
49SGK2231.01333968
50SGK4941.01333968
51GRK51.00038459
52TAOK10.98354330
53ADRBK20.98140595
54IRAK10.97579956
55PINK10.96774089
56YES10.96621717
57FGFR20.95925126
58CAMK10.95758264
59NTRK20.94217647
60SGK20.93208232
61INSRR0.92205902
62CAMK2A0.91651453
63AKT30.90194744
64NME10.88636555
65MAPK150.87945344
66SIK20.87143248
67PRKCZ0.87076053
68WNK40.86234128
69DAPK10.82784720
70CDK150.77922440
71NLK0.77670590
72CLK10.77015703
73RIPK40.75226156
74EPHA30.75042827
75CDK180.74698635
76MAP3K40.74646724
77PRKCH0.73229447
78CAMK2D0.72108114
79NEK20.71998454
80CSNK1G30.71997744
81EPHB20.71556070
82CSNK1G10.70515051
83CDK11A0.69752771
84IRAK30.68827026
85CSNK1A1L0.68688338
86PAK30.68561536
87STK110.66303397
88CSNK1G20.65527597
89PRKCE0.64675954
90PRKD20.64495647
91DYRK1A0.64282798
92EIF2AK30.64279521
93MAPKAPK50.63143108
94DYRK20.62557378
95BCR0.61577905
96CDK50.59354413
97MARK20.58764126
98PBK0.58594236
99CSK0.57334325
100ADRBK10.57239447
101PRKCG0.56537914
102CSNK1E0.56006797
103BMPR20.54680238
104ROCK20.54354017
105RPS6KA30.53586812
106ERBB20.53158258
107SGK30.51847648
108HIPK20.51370316
109IRAK40.51336538
110TIE10.50464800
111PLK20.50450379
112CAMKK20.49233094
113CSNK1D0.47870562
114MAPK100.47072759
115KSR10.46972671
116MINK10.46946849
117PRKG10.46123435
118MAPK120.44963330
119PRKAA20.44795652
120PRKACA0.44114871
121MAP2K40.43297859
122CDK30.43109560
123CAMK2G0.41915489
124TNK20.41562715
125PRKACB0.41388087
126DMPK0.40798766
127CDK140.40759184
128GSK3B0.39376655
129PHKG10.37884733
130PHKG20.37884733
131ICK0.37641017
132RPS6KA50.37593867
133MAP4K20.37321288
134MAPK80.36667456
135MAPK40.36257997
136PIK3CG0.35772585
137NTRK10.35352241
138CSNK1A10.35302418
139MST40.33937362
140ALK0.33603045
141FYN0.31533024
142TEC0.31179291
143SGK10.31157642
144DDR20.30511765
145PRKCB0.30297808
146STK380.30184267
147RET0.28511331
148PRKACG0.27535472

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.14722385
2Phototransduction_Homo sapiens_hsa047442.81443741
3Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.70894203
4Oxidative phosphorylation_Homo sapiens_hsa001902.62254505
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.45363133
6Primary bile acid biosynthesis_Homo sapiens_hsa001202.42971363
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.32664868
8Morphine addiction_Homo sapiens_hsa050322.32586697
9Glutamatergic synapse_Homo sapiens_hsa047242.26133575
10Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.21432239
11Serotonergic synapse_Homo sapiens_hsa047262.17390518
12Caffeine metabolism_Homo sapiens_hsa002322.16047270
13GABAergic synapse_Homo sapiens_hsa047272.15450244
14Taste transduction_Homo sapiens_hsa047422.00491431
15Long-term depression_Homo sapiens_hsa047301.96856395
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.88652279
17Ether lipid metabolism_Homo sapiens_hsa005651.84229616
18Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.83173934
19Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.78425524
20Alzheimers disease_Homo sapiens_hsa050101.74414927
21Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.72833392
22Ribosome_Homo sapiens_hsa030101.71751430
23Axon guidance_Homo sapiens_hsa043601.70815216
24Fatty acid elongation_Homo sapiens_hsa000621.67882436
25Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62988870
26Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.61532078
27Parkinsons disease_Homo sapiens_hsa050121.61104831
28Protein export_Homo sapiens_hsa030601.60895760
29Sphingolipid metabolism_Homo sapiens_hsa006001.60186355
30Circadian entrainment_Homo sapiens_hsa047131.56714264
31Amphetamine addiction_Homo sapiens_hsa050311.48328648
32Cardiac muscle contraction_Homo sapiens_hsa042601.43581511
33Bile secretion_Homo sapiens_hsa049761.42033952
34Salivary secretion_Homo sapiens_hsa049701.39801106
35Butanoate metabolism_Homo sapiens_hsa006501.39162712
36Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.35519173
37Calcium signaling pathway_Homo sapiens_hsa040201.33785472
38Huntingtons disease_Homo sapiens_hsa050161.32921213
39Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.30259198
40Arginine biosynthesis_Homo sapiens_hsa002201.26818855
41Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26361978
42Dopaminergic synapse_Homo sapiens_hsa047281.26049480
43Long-term potentiation_Homo sapiens_hsa047201.22525973
44Cocaine addiction_Homo sapiens_hsa050301.21612665
45Complement and coagulation cascades_Homo sapiens_hsa046101.21556917
46Chemical carcinogenesis_Homo sapiens_hsa052041.17777231
47Synaptic vesicle cycle_Homo sapiens_hsa047211.16598196
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.15221540
49Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.14641178
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.14092104
51Cholinergic synapse_Homo sapiens_hsa047251.13195001
52Tyrosine metabolism_Homo sapiens_hsa003501.12638005
53Aldosterone synthesis and secretion_Homo sapiens_hsa049251.12601722
54Phenylalanine metabolism_Homo sapiens_hsa003601.12453180
55Renin secretion_Homo sapiens_hsa049241.09065593
56Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.07248682
57Insulin secretion_Homo sapiens_hsa049111.04768780
58Olfactory transduction_Homo sapiens_hsa047401.04118926
59Arachidonic acid metabolism_Homo sapiens_hsa005900.98398527
60Vitamin B6 metabolism_Homo sapiens_hsa007500.98173469
61Wnt signaling pathway_Homo sapiens_hsa043100.96052168
62Steroid hormone biosynthesis_Homo sapiens_hsa001400.95697486
63Melanogenesis_Homo sapiens_hsa049160.93508901
64Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.92664894
65Dorso-ventral axis formation_Homo sapiens_hsa043200.92273555
66Tryptophan metabolism_Homo sapiens_hsa003800.92070757
67Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.91951568
68Prion diseases_Homo sapiens_hsa050200.91465089
69Collecting duct acid secretion_Homo sapiens_hsa049660.88916238
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86954375
71Linoleic acid metabolism_Homo sapiens_hsa005910.86661007
72Oxytocin signaling pathway_Homo sapiens_hsa049210.85823448
73cAMP signaling pathway_Homo sapiens_hsa040240.84184642
74Vascular smooth muscle contraction_Homo sapiens_hsa042700.83038491
75Fatty acid degradation_Homo sapiens_hsa000710.82605034
76Steroid biosynthesis_Homo sapiens_hsa001000.81621231
77Fanconi anemia pathway_Homo sapiens_hsa034600.79977163
78cGMP-PKG signaling pathway_Homo sapiens_hsa040220.79433698
79Estrogen signaling pathway_Homo sapiens_hsa049150.78338821
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.77114462
81Pentose and glucuronate interconversions_Homo sapiens_hsa000400.72533896
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.72477586
83Ovarian steroidogenesis_Homo sapiens_hsa049130.71887308
84Gastric acid secretion_Homo sapiens_hsa049710.71721849
85Ras signaling pathway_Homo sapiens_hsa040140.69025362
86Gap junction_Homo sapiens_hsa045400.67999792
87Histidine metabolism_Homo sapiens_hsa003400.67655012
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.67145256
89Type II diabetes mellitus_Homo sapiens_hsa049300.67011363
90Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.66683465
91beta-Alanine metabolism_Homo sapiens_hsa004100.64880682
92Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.62809712
93Rheumatoid arthritis_Homo sapiens_hsa053230.62782546
94Glioma_Homo sapiens_hsa052140.62089150
95Autoimmune thyroid disease_Homo sapiens_hsa053200.61447266
96Thyroid hormone synthesis_Homo sapiens_hsa049180.60743674
97Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.60516846
98GnRH signaling pathway_Homo sapiens_hsa049120.60431908
99Sulfur relay system_Homo sapiens_hsa041220.59410655
100Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.59230216
101RNA polymerase_Homo sapiens_hsa030200.58395866
102Phospholipase D signaling pathway_Homo sapiens_hsa040720.57434073
103Pancreatic secretion_Homo sapiens_hsa049720.57236873
104ErbB signaling pathway_Homo sapiens_hsa040120.56117294
105Drug metabolism - other enzymes_Homo sapiens_hsa009830.54939824
106Homologous recombination_Homo sapiens_hsa034400.54658929
107Oocyte meiosis_Homo sapiens_hsa041140.54261855
108alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.54135492
109Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.52985461
110Hedgehog signaling pathway_Homo sapiens_hsa043400.51563808
111Asthma_Homo sapiens_hsa053100.51460074
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51448289
113Fatty acid biosynthesis_Homo sapiens_hsa000610.51125244
114MAPK signaling pathway_Homo sapiens_hsa040100.49719027
115Malaria_Homo sapiens_hsa051440.49232583
116Basal cell carcinoma_Homo sapiens_hsa052170.48321051
117Hippo signaling pathway_Homo sapiens_hsa043900.48308481
118PPAR signaling pathway_Homo sapiens_hsa033200.48225069
119Sphingolipid signaling pathway_Homo sapiens_hsa040710.46718309
120Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.44935438
121Sulfur metabolism_Homo sapiens_hsa009200.44597063
122Melanoma_Homo sapiens_hsa052180.44232614
123Phosphatidylinositol signaling system_Homo sapiens_hsa040700.44128241
124African trypanosomiasis_Homo sapiens_hsa051430.43777241
125Circadian rhythm_Homo sapiens_hsa047100.43629000
126Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41801173
127Retinol metabolism_Homo sapiens_hsa008300.41087992
128Choline metabolism in cancer_Homo sapiens_hsa052310.41083938
129Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.40182473
130Glucagon signaling pathway_Homo sapiens_hsa049220.39729828
131Regulation of autophagy_Homo sapiens_hsa041400.39138142
132Lysine degradation_Homo sapiens_hsa003100.39103227
133Basal transcription factors_Homo sapiens_hsa030220.38535844
134Dilated cardiomyopathy_Homo sapiens_hsa054140.36425462
135Vitamin digestion and absorption_Homo sapiens_hsa049770.36347966
136Rap1 signaling pathway_Homo sapiens_hsa040150.36164190
137Cysteine and methionine metabolism_Homo sapiens_hsa002700.35523381
138Arginine and proline metabolism_Homo sapiens_hsa003300.35179693
139Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.35004385
140Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.34710160
141ABC transporters_Homo sapiens_hsa020100.34340578
142Alcoholism_Homo sapiens_hsa050340.34209000
143Purine metabolism_Homo sapiens_hsa002300.33138381
144Vibrio cholerae infection_Homo sapiens_hsa051100.33007062
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.32369119
146Metabolic pathways_Homo sapiens_hsa011000.32105102
147Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.31906062

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