CUZD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of epidermis development (GO:0045683)9.00808551
2exocrine pancreas development (GO:0031017)8.07699191
3intestinal cholesterol absorption (GO:0030299)7.86951732
4neutrophil mediated immunity (GO:0002446)7.45596190
5regulation of acrosome reaction (GO:0060046)7.01236985
6arachidonic acid secretion (GO:0050482)6.97163403
7icosanoid secretion (GO:0032309)6.97163403
8fusion of sperm to egg plasma membrane (GO:0007342)6.85577551
9protein retention in ER lumen (GO:0006621)6.67709363
10positive regulation of antigen processing and presentation (GO:0002579)6.66871445
11digestion (GO:0007586)6.54263659
12phosphatidylinositol acyl-chain remodeling (GO:0036149)6.48732329
13phosphatidylglycerol acyl-chain remodeling (GO:0036148)6.46971520
14maintenance of protein localization in endoplasmic reticulum (GO:0035437)6.43605282
15phosphatidylserine acyl-chain remodeling (GO:0036150)6.26617599
16regulation of keratinocyte proliferation (GO:0010837)6.07031956
17regulation of keratinocyte differentiation (GO:0045616)5.74403961
18icosanoid transport (GO:0071715)5.57396198
19fatty acid derivative transport (GO:1901571)5.57396198
20regulation of clathrin-mediated endocytosis (GO:2000369)5.57083308
21transcytosis (GO:0045056)5.54891373
22tetrapyrrole metabolic process (GO:0033013)5.53782210
23innate immune response in mucosa (GO:0002227)5.36374026
24myeloid leukocyte mediated immunity (GO:0002444)5.31142695
25regulation of antigen processing and presentation (GO:0002577)5.30207534
26plasma membrane fusion (GO:0045026)5.18960703
27cellular protein catabolic process (GO:0044257)5.03157759
28valine metabolic process (GO:0006573)4.97979878
29complement activation, alternative pathway (GO:0006957)4.89475724
30cysteine metabolic process (GO:0006534)4.72753203
31phosphatidylethanolamine acyl-chain remodeling (GO:0036152)4.50771547
32digestive system process (GO:0022600)4.50101233
33leukotriene biosynthetic process (GO:0019370)4.40377508
34mucosal immune response (GO:0002385)4.39452455
35daunorubicin metabolic process (GO:0044597)4.38808376
36polyketide metabolic process (GO:0030638)4.38808376
37doxorubicin metabolic process (GO:0044598)4.38808376
38cholesterol transport (GO:0030301)4.38185404
39sterol transport (GO:0015918)4.38185404
40L-alpha-amino acid transmembrane transport (GO:1902475)4.36214175
41Golgi transport vesicle coating (GO:0048200)4.29796819
42COPI coating of Golgi vesicle (GO:0048205)4.29796819
43sulfur amino acid catabolic process (GO:0000098)4.25011817
44sphingolipid catabolic process (GO:0030149)4.18067565
45antibacterial humoral response (GO:0019731)4.13579942
46water-soluble vitamin metabolic process (GO:0006767)4.07434887
47aminoglycoside antibiotic metabolic process (GO:0030647)3.98309203
48phosphatidylserine metabolic process (GO:0006658)3.95752135
49organ or tissue specific immune response (GO:0002251)3.95345770
50phosphatidylcholine acyl-chain remodeling (GO:0036151)3.93585570
51branched-chain amino acid catabolic process (GO:0009083)3.87515227
52cellular modified amino acid catabolic process (GO:0042219)3.87447567
53peptidyl-proline hydroxylation (GO:0019511)3.83110785
54regulation of phospholipase A2 activity (GO:0032429)3.76656585
55antimicrobial humoral response (GO:0019730)3.73608089
56positive regulation of respiratory burst (GO:0060267)3.73448927
57acute-phase response (GO:0006953)3.67854875
58branched-chain amino acid metabolic process (GO:0009081)3.66502806
59macroautophagy (GO:0016236)3.61143895
60intestinal absorption (GO:0050892)3.59680841
61nucleotide-sugar biosynthetic process (GO:0009226)3.59575100
62cholesterol catabolic process (GO:0006707)3.57864403
63sterol catabolic process (GO:0016127)3.57864403
64homocysteine metabolic process (GO:0050667)3.53096841
65negative regulation of digestive system process (GO:0060457)3.51682205
66regulation of epidermal cell differentiation (GO:0045604)3.49001180
67phosphatidic acid metabolic process (GO:0046473)3.48053657
68phosphatidic acid biosynthetic process (GO:0006654)3.48053657
69defense response to Gram-positive bacterium (GO:0050830)3.45375192
70negative regulation of receptor-mediated endocytosis (GO:0048261)3.42757363
71regulation of complement activation (GO:0030449)3.29349459
72cobalamin metabolic process (GO:0009235)3.24984667
73calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)3.24964451
74phospholipid catabolic process (GO:0009395)3.24126699
75alditol phosphate metabolic process (GO:0052646)3.21013486
76negative regulation of epithelial cell differentiation (GO:0030857)3.18935411
77activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.16232452
78regulation of protein activation cascade (GO:2000257)3.09492393
79retinoid metabolic process (GO:0001523)3.06911990
80vitamin metabolic process (GO:0006766)3.06197772
81protein hydroxylation (GO:0018126)3.03026628
82endothelial cell migration (GO:0043542)2.98159472
83regulation of cardioblast differentiation (GO:0051890)2.97851779
84positive regulation of nuclease activity (GO:0032075)2.97793657
85pyrimidine ribonucleoside catabolic process (GO:0046133)2.95581318
86glycolipid catabolic process (GO:0019377)2.93048435
87diterpenoid metabolic process (GO:0016101)2.90418992
88leukotriene metabolic process (GO:0006691)2.86655780
89serine family amino acid biosynthetic process (GO:0009070)2.81828677
90multicellular organismal catabolic process (GO:0044243)2.80758753
91ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.80727294
92phosphatidylglycerol metabolic process (GO:0046471)2.79864192
93retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.79585005
94phototransduction, visible light (GO:0007603)2.77893686
95regulation of calcium ion import (GO:0090279)2.75687571
96endoplasmic reticulum unfolded protein response (GO:0030968)2.74796444
97membrane lipid catabolic process (GO:0046466)2.73819044
98L-serine metabolic process (GO:0006563)2.73466652
99cytolysis (GO:0019835)2.73091275
100regulation of calcium ion-dependent exocytosis (GO:0017158)2.70520205
1014-hydroxyproline metabolic process (GO:0019471)2.70188569
102cholesterol metabolic process (GO:0008203)2.70166966
103zinc ion transport (GO:0006829)2.69674993
104response to endoplasmic reticulum stress (GO:0034976)2.68600000
105positive regulation of wound healing (GO:0090303)2.67694640
106epithelial cell differentiation involved in kidney development (GO:0035850)2.67054073
107cellular response to cadmium ion (GO:0071276)2.66927920
108nucleoside diphosphate catabolic process (GO:0009134)2.66140192
109cellular response to topologically incorrect protein (GO:0035967)2.66121011
110aspartate family amino acid catabolic process (GO:0009068)2.65530189
111cellular response to unfolded protein (GO:0034620)2.65109911
112regulation of Cdc42 GTPase activity (GO:0043088)2.64870597
113regulation of nuclease activity (GO:0032069)2.64550005
114mannose metabolic process (GO:0006013)2.60925917
115multicellular organismal metabolic process (GO:0044236)2.60826476
116terpenoid metabolic process (GO:0006721)2.60694235
117creatine metabolic process (GO:0006600)2.59728394
118COPII vesicle coating (GO:0048208)2.56441639
119mitochondrial calcium ion transport (GO:0006851)2.55518477
120response to misfolded protein (GO:0051788)2.53242045
121UDP-N-acetylglucosamine metabolic process (GO:0006047)2.51862363
122photoreceptor cell differentiation (GO:0046530)2.51443258
123eye photoreceptor cell differentiation (GO:0001754)2.51443258
124ribosome assembly (GO:0042255)2.51332441
125ER-nucleus signaling pathway (GO:0006984)2.50794886
126maintenance of gastrointestinal epithelium (GO:0030277)2.47691758
127sterol metabolic process (GO:0016125)2.47488981
128regulation of hydrogen peroxide-induced cell death (GO:1903205)2.47444770
129regulation of T cell tolerance induction (GO:0002664)2.46614161
130acute inflammatory response (GO:0002526)2.46566145
131fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.45925628
132alpha-linolenic acid metabolic process (GO:0036109)2.45247759
133glutamine metabolic process (GO:0006541)2.44781476
134regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.43097930
135regulation of transforming growth factor beta2 production (GO:0032909)2.43058736
136negative regulation of endopeptidase activity (GO:0010951)2.42463912
137protein maturation by protein folding (GO:0022417)2.41205865
138cellular sodium ion homeostasis (GO:0006883)2.41197151
139establishment of integrated proviral latency (GO:0075713)2.41071666
140regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.40295386
141cellular response to zinc ion (GO:0071294)2.39865566
142L-phenylalanine catabolic process (GO:0006559)2.39476444
143erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.39476444
144negative regulation of protein autophosphorylation (GO:0031953)2.35342292
145gland morphogenesis (GO:0022612)2.34657743
146water-soluble vitamin biosynthetic process (GO:0042364)2.33954516
147negative regulation of peptidase activity (GO:0010466)2.33691309
148fatty acid derivative biosynthetic process (GO:1901570)2.32503016
149icosanoid biosynthetic process (GO:0046456)2.32503016
150uronic acid metabolic process (GO:0006063)2.32356047
151glucuronate metabolic process (GO:0019585)2.32356047
152ceramide catabolic process (GO:0046514)2.32287567
153biotin metabolic process (GO:0006768)2.30467947
154proline biosynthetic process (GO:0006561)2.30266971
155serine family amino acid metabolic process (GO:0009069)2.30165608
156detection of visible light (GO:0009584)2.29868572
157regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.29530100
158positive regulation of hair follicle development (GO:0051798)2.29499283
159positive regulation of hair cycle (GO:0042635)2.29499283
160regulation of epidermis development (GO:0045682)2.27802689
161primary alcohol catabolic process (GO:0034310)2.27773454
162seminiferous tubule development (GO:0072520)2.27065802
163cellular glucuronidation (GO:0052695)2.27002585
164regulation of alkaline phosphatase activity (GO:0010692)2.26803048
165positive regulation of guanylate cyclase activity (GO:0031284)2.26431742
166extracellular matrix disassembly (GO:0022617)2.26259664
167isoprenoid metabolic process (GO:0006720)2.26085534
168glutathione derivative biosynthetic process (GO:1901687)2.25631070
169glutathione derivative metabolic process (GO:1901685)2.25631070
170peptide catabolic process (GO:0043171)2.24710313
171kynurenine metabolic process (GO:0070189)2.24107923
172signal peptide processing (GO:0006465)2.22844807
173nodal signaling pathway (GO:0038092)2.22827069
174paraxial mesoderm development (GO:0048339)2.21845990
175steroid catabolic process (GO:0006706)2.21344601
176response to nitrosative stress (GO:0051409)2.20461439
177antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)15.4902768
178antigen processing and presentation of endogenous peptide antigen (GO:0002483)15.4902768
179antigen processing and presentation via MHC class Ib (GO:0002475)15.3762032
180regulation of antigen processing and presentation of peptide antigen (GO:0002583)13.8865974
181antigen processing and presentation of endogenous antigen (GO:0019883)12.8148120
182negative regulation of epidermal cell differentiation (GO:0045605)11.1923897

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.93541646
2KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.93541646
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.93541646
4TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.79724382
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.47660117
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.34358148
7ESR1_21235772_ChIP-Seq_MCF-7_Human3.23289736
8ESR2_21235772_ChIP-Seq_MCF-7_Human2.90838228
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.81489281
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.47191169
11E2F7_22180533_ChIP-Seq_HELA_Human2.39911677
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.32880411
13LXR_22158963_ChIP-Seq_LIVER_Mouse2.31866467
14CLOCK_20551151_ChIP-Seq_293T_Human2.31046905
15HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.30460749
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.28495805
17TRIM28_21343339_ChIP-Seq_HEK293_Human2.22306543
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.13718772
19PPARA_22158963_ChIP-Seq_LIVER_Mouse2.11194411
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.02107712
21GATA1_22025678_ChIP-Seq_K562_Human10.5737801
22AR_21572438_ChIP-Seq_LNCaP_Human1.91076363
23HTT_18923047_ChIP-ChIP_STHdh_Human1.81956714
24SOX2_27498859_Chip-Seq_STOMACH_Mouse1.81425099
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.80747712
26FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79351907
27ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72009591
28STAT6_21828071_ChIP-Seq_BEAS2B_Human1.70554430
29SOX2_18555785_ChIP-Seq_MESCs_Mouse1.68095567
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.67346058
31CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.66407158
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.64189443
33CREB1_15753290_ChIP-ChIP_HEK293T_Human1.63607208
34SOX2_20726797_ChIP-Seq_SW620_Human1.58760331
35PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.57634555
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.56025093
37PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.54721572
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53851284
39ERG_21242973_ChIP-ChIP_JURKAT_Human1.53763817
40LXR_22292898_ChIP-Seq_THP-1_Human1.51777857
41ELK1_19687146_ChIP-ChIP_HELA_Human1.51023872
42FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.50077693
43ETV1_20927104_ChIP-Seq_GIST48_Human1.48337125
44RARG_19884340_ChIP-ChIP_MEFs_Mouse1.48090104
45RBPJ_21746931_ChIP-Seq_IB4_Human1.47843243
46PHF8_20622853_ChIP-Seq_HELA_Human1.46752175
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.46595453
48AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.44029251
49HNFA_21074721_ChIP-Seq_CACO-2_Human1.43972716
50MYC_19030024_ChIP-ChIP_MESCs_Mouse1.42501234
51NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.42409469
52IGF1R_20145208_ChIP-Seq_DFB_Human1.42369584
53CDX2_21074721_ChIP-Seq_CACO-2_Mouse1.40838265
54STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.38426626
55GATA6_21074721_ChIP-Seq_CACO-2_Human1.38004069
56NFYA_21822215_ChIP-Seq_K562_Human1.36919708
57GATA4_25053715_ChIP-Seq_YYC3_Human1.35704748
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.35288699
59GATA6_21074721_ChIP-Seq_CACO-2_Mouse1.35141347
60CBX2_22325352_ChIP-Seq_293T-Rex_Human1.34929578
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.34261888
62ZNF263_19887448_ChIP-Seq_K562_Human1.33333065
63* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.33217779
64E2F4_17652178_ChIP-ChIP_JURKAT_Human1.31134359
65SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.30812595
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.29508300
67TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29220023
68SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.29047759
69ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28705926
70EP300_21415370_ChIP-Seq_HL-1_Mouse1.26929389
71NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.24589394
72FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.23341590
73TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23029535
74ZNF274_21170338_ChIP-Seq_K562_Hela1.22322643
75FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.22049616
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.22046032
77PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.22043528
78* MYC_19915707_ChIP-ChIP_AK7_Human1.21131415
79PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20095767
80ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.19180228
81ELK4_26923725_Chip-Seq_MESODERM_Mouse1.18916922
82ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.17498604
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.17204297
84SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17083534
85TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.16852541
86P300_19829295_ChIP-Seq_ESCs_Human1.16417664
87P63_26484246_Chip-Seq_KERATINOCYTES_Human1.15332534
88DNAJC2_21179169_ChIP-ChIP_NT2_Human1.14779336
89CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14148866
90FLI1_27457419_Chip-Seq_LIVER_Mouse1.13463532
91NFYB_21822215_ChIP-Seq_K562_Human1.13430091
92AR_21909140_ChIP-Seq_LNCAP_Human1.12078149
93E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11180612
94CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10782161
95CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09474035
96NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08975991
97FOXA1_25552417_ChIP-Seq_VCAP_Human1.08306718
98RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.07618481
99FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.05504421
100TAF15_26573619_Chip-Seq_HEK293_Human1.04182909
101GATA6_25053715_ChIP-Seq_YYC3_Human1.03226114
102TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02640766
103PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.02266567
104MYC_18358816_ChIP-ChIP_MESCs_Mouse1.02212864
105TP63_17297297_ChIP-ChIP_HaCaT_Human1.02144249
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.02142914
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.02142914
108POU3F2_20337985_ChIP-ChIP_501MEL_Human1.01587371
109PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00239289
110FOXA2_19822575_ChIP-Seq_HepG2_Human0.99590193
111EGR1_19032775_ChIP-ChIP_M12_Human0.99512497
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.98743593
113AHR_22903824_ChIP-Seq_MCF-7_Human0.98691599
114ESET_19884257_ChIP-Seq_ESCs_Mouse0.98633067
115GATA3_24758297_ChIP-Seq_MCF-7_Human0.98461505
116ARNT_22903824_ChIP-Seq_MCF-7_Human0.97308443
117EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse0.96613431
118P68_20966046_ChIP-Seq_HELA_Human0.96037513
119TAF2_19829295_ChIP-Seq_ESCs_Human0.95732688
120BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95639102
121RACK7_27058665_Chip-Seq_MCF-7_Human0.95152834
122HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.94714545
123NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.94316211
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.93801711
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.93533879
126FOXH1_21741376_ChIP-Seq_ESCs_Human0.92898440
127GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.92508436
128FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.91908074
129PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91769621
130SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.91584736
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.91502526
132RNF2_18974828_ChIP-Seq_MESCs_Mouse0.91151702
133EZH2_18974828_ChIP-Seq_MESCs_Mouse0.91151702
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.90301120
135NANOG_16153702_ChIP-ChIP_HESCs_Human0.89954350
136FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.89938725
137JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.89750406
138MYC_18940864_ChIP-ChIP_HL60_Human0.89528718
139EGR1_23403033_ChIP-Seq_LIVER_Mouse0.89497347
140BCOR_27268052_Chip-Seq_Bcells_Human0.87529115
141OCT4_20526341_ChIP-Seq_ESCs_Human0.87476778
142TCF3_18692474_ChIP-Seq_MESCs_Mouse0.87401029
143Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.87254344
144HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.86834814
145BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86796794
146SOX17_20123909_ChIP-Seq_XEN_Mouse0.86457745
147SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.86453967
148PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.85744297
149TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.85721981
150CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.83888505
151VDR_23849224_ChIP-Seq_CD4+_Human0.83560993
152FOXA1_21572438_ChIP-Seq_LNCaP_Human0.83039377
153NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82317854
154KLF4_19829295_ChIP-Seq_ESCs_Human0.81776331
155MYCN_18555785_ChIP-Seq_MESCs_Mouse0.81715878
156ELF1_17652178_ChIP-ChIP_JURKAT_Human0.81576821
157RXRA_24833708_ChIP-Seq_LIVER_Mouse0.81001545
158ELF1_20517297_ChIP-Seq_JURKAT_Human0.80755005
159E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.80258663
160SMC4_20622854_ChIP-Seq_HELA_Human0.80139651
161SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.80122925
162KDM2B_26808549_Chip-Seq_K562_Human0.80070623
163FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.80030393
164TP63_22573176_ChIP-Seq_HFKS_Human0.79779637
165TBL1_22424771_ChIP-Seq_293T_Human0.79371786
166E2F1_21310950_ChIP-Seq_MCF-7_Human0.79303022
167CDX2_22108803_ChIP-Seq_LS180_Human0.78977733
168FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.78569574
169HOXB4_20404135_ChIP-ChIP_EML_Mouse0.78464959
170SMAD4_21741376_ChIP-Seq_ESCs_Human0.77855778
171RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.77310899
172GATA2_21666600_ChIP-Seq_HMVEC_Human0.77020787
173SALL4_18804426_ChIP-ChIP_XEN_Mouse0.76814774
174PIAS1_25552417_ChIP-Seq_VCAP_Human0.76083767
175SALL1_21062744_ChIP-ChIP_HESCs_Human0.76025155
176NR3C1_23031785_ChIP-Seq_PC12_Mouse0.75954660
177GATA1_19941826_ChIP-Seq_K562_Human0.75888589
178ATF3_27146783_Chip-Seq_COLON_Human0.75845848
179SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75726556
180CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.75274402
181SOX9_24532713_ChIP-Seq_HFSC_Mouse0.74984729
182SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.74943947
183* CEBPB_22108803_ChIP-Seq_LS180_Human0.73970057
184VDR_24787735_ChIP-Seq_THP-1_Human0.73449739
185CREB1_26743006_Chip-Seq_LNCaP_Human0.73247232

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001666_abnormal_nutrient_absorption6.60603068
2MP0005083_abnormal_biliary_tract5.88922456
3MP0005365_abnormal_bile_salt4.96744098
4MP0005220_abnormal_exocrine_pancreas4.51304518
5MP0008438_abnormal_cutaneous_collagen3.40612263
6MP0005058_abnormal_lysosome_morphology3.36933380
7MP0008004_abnormal_stomach_pH3.29518329
8MP0003941_abnormal_skin_development2.89365958
9MP0003868_abnormal_feces_composition2.88671461
10MP0005084_abnormal_gallbladder_morpholo2.70530007
11MP0002139_abnormal_hepatobiliary_system2.68946397
12MP0005085_abnormal_gallbladder_physiolo2.63034216
13MP0001664_abnormal_digestion2.60358017
14MP0010234_abnormal_vibrissa_follicle2.55516249
15MP0006054_spinal_hemorrhage2.55398526
16MP0002254_reproductive_system_inflammat2.54064014
17MP0003705_abnormal_hypodermis_morpholog2.49243186
18MP0003252_abnormal_bile_duct1.97659507
19MP0002138_abnormal_hepatobiliary_system1.95098669
20MP0008875_abnormal_xenobiotic_pharmacok1.89437184
21MP0005275_abnormal_skin_tensile1.77813465
22MP0003693_abnormal_embryo_hatching1.76625890
23MP0003959_abnormal_lean_body1.69892003
24MP0004264_abnormal_extraembryonic_tissu1.69405811
25MP0001765_abnormal_ion_homeostasis1.68330232
26MP0003329_amyloid_beta_deposits1.67118504
27MP0000681_abnormal_thyroid_gland1.65662310
28MP0002876_abnormal_thyroid_physiology1.63705687
29MP0000003_abnormal_adipose_tissue1.61308228
30MP0000604_amyloidosis1.56983149
31MP0003300_gastrointestinal_ulcer1.54920112
32MP0002118_abnormal_lipid_homeostasis1.52483254
33MP0005636_abnormal_mineral_homeostasis1.51030903
34MP0005670_abnormal_white_adipose1.50691482
35MP0009384_cardiac_valve_regurgitation1.43305007
36MP0009643_abnormal_urine_homeostasis1.41072789
37MP0003638_abnormal_response/metabolism_1.39930327
38MP0010352_gastrointestinal_tract_polyps1.35417191
39* MP0002693_abnormal_pancreas_physiology1.32574998
40MP0005332_abnormal_amino_acid1.32349803
41MP0010329_abnormal_lipoprotein_level1.31368102
42MP0004957_abnormal_blastocyst_morpholog1.27936371
43MP0003011_delayed_dark_adaptation1.26607887
44MP0001873_stomach_inflammation1.24942109
45MP0005375_adipose_tissue_phenotype1.24783135
46MP0005452_abnormal_adipose_tissue1.24098355
47MP0003045_fibrosis1.21088863
48MP0005448_abnormal_energy_balance1.20978504
49MP0004272_abnormal_basement_membrane1.19634979
50MP0001944_abnormal_pancreas_morphology1.18333940
51MP0000613_abnormal_salivary_gland1.12732664
52MP0004019_abnormal_vitamin_homeostasis1.11312247
53MP0008007_abnormal_cellular_replicative1.08295320
54MP0001958_emphysema1.05418734
55MP0002796_impaired_skin_barrier1.01401388
56MP0002928_abnormal_bile_duct1.00302123
57MP0003566_abnormal_cell_adhesion1.00211488
58MP0003191_abnormal_cellular_cholesterol0.99129244
59MP0010386_abnormal_urinary_bladder0.98294532
60MP0005377_hearing/vestibular/ear_phenot0.97868912
61MP0003878_abnormal_ear_physiology0.97868912
62MP0002132_abnormal_respiratory_system0.95880649
63MP0001756_abnormal_urination0.95406747
64MP0004858_abnormal_nervous_system0.91889302
65MP0003195_calcinosis0.91585780
66MP0004185_abnormal_adipocyte_glucose0.89699639
67MP0003890_abnormal_embryonic-extraembry0.89632469
68MP0005666_abnormal_adipose_tissue0.88183057
69MP0008058_abnormal_DNA_repair0.87989869
70MP0002163_abnormal_gland_morphology0.87120554
71MP0005165_increased_susceptibility_to0.86134215
72MP0001177_atelectasis0.85655095
73MP0005408_hypopigmentation0.84835112
74MP0001661_extended_life_span0.84406669
75MP0004130_abnormal_muscle_cell0.84216638
76MP0010678_abnormal_skin_adnexa0.83130715
77MP0002277_abnormal_respiratory_mucosa0.82623721
78MP0000609_abnormal_liver_physiology0.81057685
79MP0001730_embryonic_growth_arrest0.79918536
80MP0003718_maternal_effect0.79128559
81MP0009780_abnormal_chondrocyte_physiolo0.78603275
82MP0002060_abnormal_skin_morphology0.76610097
83MP0002078_abnormal_glucose_homeostasis0.75781521
84MP0003953_abnormal_hormone_level0.74324515
85MP0001501_abnormal_sleep_pattern0.73557491
86MP0003943_abnormal_hepatobiliary_system0.73314640
87MP0008877_abnormal_DNA_methylation0.72988825
88MP0000013_abnormal_adipose_tissue0.72917689
89MP0000230_abnormal_systemic_arterial0.72121877
90MP0008932_abnormal_embryonic_tissue0.71814508
91MP0005360_urolithiasis0.71710833
92MP0000462_abnormal_digestive_system0.70758379
93MP0008057_abnormal_DNA_replication0.69857966
94MP0010094_abnormal_chromosome_stability0.68964389
95MP0005647_abnormal_sex_gland0.68058468
96MP0001727_abnormal_embryo_implantation0.67832716
97MP0004233_abnormal_muscle_weight0.67628526
98MP0003656_abnormal_erythrocyte_physiolo0.66015447
99MP0002837_dystrophic_cardiac_calcinosis0.65793656
100MP0001881_abnormal_mammary_gland0.63423497
101MP0002136_abnormal_kidney_physiology0.61647005
102MP0005410_abnormal_fertilization0.61537482
103MP0005535_abnormal_body_temperature0.60593355
104MP0005334_abnormal_fat_pad0.59411096
105MP0009672_abnormal_birth_weight0.58712822
106MP0002896_abnormal_bone_mineralization0.58036324
107MP0005319_abnormal_enzyme/_coenzyme0.57870381
108MP0002098_abnormal_vibrissa_morphology0.57603376
109MP0003111_abnormal_nucleus_morphology0.57515901
110MP0005584_abnormal_enzyme/coenzyme_acti0.57488650
111MP0005380_embryogenesis_phenotype0.57198254
112MP0001672_abnormal_embryogenesis/_devel0.57198254
113MP0002084_abnormal_developmental_patter0.57096192
114MP0000598_abnormal_liver_morphology0.56602802
115MP0003795_abnormal_bone_structure0.56326972
116MP0001731_abnormal_postnatal_growth0.55721882
117MP0002168_other_aberrant_phenotype0.55529570
118MP0002135_abnormal_kidney_morphology0.54520048
119MP0001485_abnormal_pinna_reflex0.53715803
120MP0002295_abnormal_pulmonary_circulatio0.53556864
121MP0001764_abnormal_homeostasis0.50991934
122MP0005379_endocrine/exocrine_gland_phen0.50939585
123MP0004043_abnormal_pH_regulation0.50551822
124MP0000750_abnormal_muscle_regeneration0.50242712
125MP0002998_abnormal_bone_remodeling0.48115671
126MP0002970_abnormal_white_adipose0.47697494
127MP0009703_decreased_birth_body0.47630736
128MP0005164_abnormal_response_to0.47090348
129MP0003632_abnormal_nervous_system0.47063220
130MP0000639_abnormal_adrenal_gland0.45772241
131MP0003567_abnormal_fetal_cardiomyocyte0.45675774
132MP0009642_abnormal_blood_homeostasis0.45207606
133MP0003283_abnormal_digestive_organ0.44237307
134MP0008770_decreased_survivor_rate0.44086796
135MP0000432_abnormal_head_morphology0.42834649
136MP0002086_abnormal_extraembryonic_tissu0.42450443
137MP0008961_abnormal_basal_metabolism0.42094540
138MP0002088_abnormal_embryonic_growth/wei0.41517793
139MP0003984_embryonic_growth_retardation0.41185614
140MP0005395_other_phenotype0.41110041
141MP0003077_abnormal_cell_cycle0.39882821
142MP0006035_abnormal_mitochondrial_morpho0.37867477
143MP0002085_abnormal_embryonic_tissue0.36547637
144MP0003786_premature_aging0.35173612
145MP0000350_abnormal_cell_proliferation0.34164598
146MP0003123_paternal_imprinting0.33870825
147MP0001697_abnormal_embryo_size0.33521227
148MP0008872_abnormal_physiological_respon0.33073243
149MP0002089_abnormal_postnatal_growth/wei0.31299448
150MP0001188_hyperpigmentation0.31233937
151MP0002080_prenatal_lethality0.30865918
152MP0002233_abnormal_nose_morphology0.29961380
153MP0000470_abnormal_stomach_morphology0.29170489
154MP0000490_abnormal_crypts_of0.26345563
155MP0001145_abnormal_male_reproductive0.25405384
156MP0003937_abnormal_limbs/digits/tail_de0.25351425
157MP0005621_abnormal_cell_physiology0.25169069
158MP0003119_abnormal_digestive_system0.25131023

Predicted human phenotypes

RankGene SetZ-score
1Complement deficiency (HP:0004431)5.90626478
2Spondylolisthesis (HP:0003302)5.49739495
3Vacuolated lymphocytes (HP:0001922)5.23565253
4Aortic dissection (HP:0002647)4.98615698
5Arterial tortuosity (HP:0005116)4.85428551
6Vascular tortuosity (HP:0004948)4.30248195
7Abnormality of complement system (HP:0005339)4.11268808
8Tubulointerstitial fibrosis (HP:0005576)3.72853410
9Abnormality of the pleura (HP:0002103)3.66563690
10Steatorrhea (HP:0002570)3.65023684
11Choroideremia (HP:0001139)3.64223999
12Potter facies (HP:0002009)3.58582892
13Facial shape deformation (HP:0011334)3.58582892
14Aortic aneurysm (HP:0004942)3.47689745
15Gout (HP:0001997)3.46488146
16Myocardial infarction (HP:0001658)3.45989251
17Dysostosis multiplex (HP:0000943)3.45619631
18Vascular calcification (HP:0004934)3.40982907
19Abnormality of methionine metabolism (HP:0010901)3.31652051
20Hypoglycemic seizures (HP:0002173)3.31439003
21Cardiovascular calcification (HP:0011915)3.30187403
22Anal atresia (HP:0002023)3.23385877
23Fat malabsorption (HP:0002630)3.22214873
24Hand muscle atrophy (HP:0009130)3.11146976
25Malnutrition (HP:0004395)3.09920525
26Abnormality of the fovea (HP:0000493)3.05713622
27Hyperinsulinemic hypoglycemia (HP:0000825)3.03921158
28Abnormal rod and cone electroretinograms (HP:0008323)3.03572575
29Thin bony cortex (HP:0002753)2.96692255
30Recurrent gram-negative bacterial infections (HP:0005420)2.95888225
31Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76542312
32Central scotoma (HP:0000603)2.73535834
33Ketoacidosis (HP:0001993)2.72830425
34Neoplasm of the heart (HP:0100544)2.72191578
35Bony spicule pigmentary retinopathy (HP:0007737)2.71653769
36Mitral valve prolapse (HP:0001634)2.70878051
37Premature skin wrinkling (HP:0100678)2.67950018
38Facial diplegia (HP:0001349)2.67354366
39Proximal tubulopathy (HP:0000114)2.66235649
40Short chin (HP:0000331)2.64040818
41Upper limb amyotrophy (HP:0009129)2.61489573
42Distal upper limb amyotrophy (HP:0007149)2.61489573
43Mucopolysacchariduria (HP:0008155)2.61429318
44Urinary glycosaminoglycan excretion (HP:0003541)2.61429318
45Abnormality of the pons (HP:0007361)2.61188719
46Hyperglycinuria (HP:0003108)2.59244638
47Tetraparesis (HP:0002273)2.56937317
48Pancreatitis (HP:0001733)2.56607139
49Type I transferrin isoform profile (HP:0003642)2.55090130
50Homocystinuria (HP:0002156)2.54223725
51Abnormality of homocysteine metabolism (HP:0010919)2.54223725
52Abnormality of macular pigmentation (HP:0008002)2.53422683
53Multiple enchondromatosis (HP:0005701)2.51526978
54Stenosis of the external auditory canal (HP:0000402)2.48284017
55Long foot (HP:0001833)2.47114315
56Abnormality of the calcaneus (HP:0008364)2.46474782
57Symptomatic seizures (HP:0011145)2.42213205
58Ketosis (HP:0001946)2.42082406
59Hyperglycinemia (HP:0002154)2.41677733
60Cone-rod dystrophy (HP:0000548)2.41255149
61Infantile muscular hypotonia (HP:0008947)2.40979403
62Ankle contracture (HP:0006466)2.40757249
63Abnormality of polysaccharide metabolism (HP:0011012)2.39414887
64Abnormality of glycosaminoglycan metabolism (HP:0004371)2.39414887
65Abnormality of mucopolysaccharide metabolism (HP:0011020)2.39414887
66Abnormal pancreas size (HP:0012094)2.37592480
67Ventricular fibrillation (HP:0001663)2.36732154
68Neoplasm of the pancreas (HP:0002894)2.34878752
69Methylmalonic acidemia (HP:0002912)2.32083251
70Esophageal varix (HP:0002040)2.31230037
71Hyperphosphatemia (HP:0002905)2.31171580
72Reduced antithrombin III activity (HP:0001976)2.30660303
73Glomerulosclerosis (HP:0000096)2.30004280
74Stridor (HP:0010307)2.28860286
75Myopathic facies (HP:0002058)2.28640275
76Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27290106
77Abnormal protein N-linked glycosylation (HP:0012347)2.27290106
78Abnormal protein glycosylation (HP:0012346)2.27290106
79Abnormal glycosylation (HP:0012345)2.27290106
80Decreased subcutaneous fat (HP:0001002)2.26871260
81Joint stiffness (HP:0001387)2.24143362
8211 pairs of ribs (HP:0000878)2.22231950
83Abnormality of serine family amino acid metabolism (HP:0010894)2.21369856
84Abnormality of glycine metabolism (HP:0010895)2.21369856
85Exocrine pancreatic insufficiency (HP:0001738)2.20582794
86Thyroid-stimulating hormone excess (HP:0002925)2.20552461
87Abnormality of the intrinsic pathway (HP:0010989)2.19554512
88Abnormal biliary tract morphology (HP:0012440)2.18656119
89Abnormality of the common coagulation pathway (HP:0010990)2.17576739
90Hyperparathyroidism (HP:0000843)2.17160541
91Right ventricular cardiomyopathy (HP:0011663)2.16926521
92Systemic lupus erythematosus (HP:0002725)2.15409303
93Abnormality of sulfur amino acid metabolism (HP:0004339)2.15225841
94Metaphyseal cupping (HP:0003021)2.15097233
95Pancreatic islet-cell hyperplasia (HP:0004510)2.14065780
96Hypopigmentation of the fundus (HP:0007894)2.12681693
97Cerebral aneurysm (HP:0004944)2.10138144
98Bicuspid aortic valve (HP:0001647)2.09856557
99Abnormality of the pancreatic islet cells (HP:0006476)2.09322022
100Abnormality of endocrine pancreas physiology (HP:0012093)2.09322022
101Hypoplasia of the pons (HP:0012110)2.07736063
102Action tremor (HP:0002345)2.07356086
103Tubulointerstitial abnormality (HP:0001969)2.07162001
104Type I diabetes mellitus (HP:0100651)2.05579089
105Abnormality of purine metabolism (HP:0004352)2.05293042
106Osteolytic defects of the hand bones (HP:0009699)2.05066151
107Osteolytic defects of the phalanges of the hand (HP:0009771)2.05066151
108Abnormality of subcutaneous fat tissue (HP:0001001)2.02990283
109Hyporeflexia of lower limbs (HP:0002600)2.02711497
110Ileus (HP:0002595)2.02495302
111Large for gestational age (HP:0001520)2.02052999
112Abnormality of the labia minora (HP:0012880)2.01541426
113Facial cleft (HP:0002006)2.00293610
114Progressive visual loss (HP:0000529)1.98587404
115Megaloblastic anemia (HP:0001889)1.97864187
116Cervical subluxation (HP:0003308)1.96520492
117Intention tremor (HP:0002080)1.96298011
118Maternal diabetes (HP:0009800)1.94535707
119Hyperthyroidism (HP:0000836)1.93899001
120Focal segmental glomerulosclerosis (HP:0000097)1.93221005
121Hypoproteinemia (HP:0003075)1.89109942
122Dyschromatopsia (HP:0007641)1.85761157
123Aneurysm (HP:0002617)1.85738543
124Absent eyebrow (HP:0002223)1.84841951
125Prolonged QT interval (HP:0001657)1.84388294
126Azoospermia (HP:0000027)1.84272459
127Methylmalonic aciduria (HP:0012120)1.83916787
128Beaking of vertebral bodies (HP:0004568)1.83509150
129Male infertility (HP:0003251)1.83403691
130Diaphragmatic weakness (HP:0009113)1.77267338
131Rectal prolapse (HP:0002035)1.76503668
132Abnormality of serum amino acid levels (HP:0003112)1.74628441
133Type 1 muscle fiber predominance (HP:0003803)1.73050161
134Gastrointestinal dysmotility (HP:0002579)1.73031837
135Hypoglycemic coma (HP:0001325)1.72233291
136Abnormal spermatogenesis (HP:0008669)1.72220182
137Prenatal maternal abnormality (HP:0002686)1.71844721
138Colon cancer (HP:0003003)1.71013852
139Hypophosphatemic rickets (HP:0004912)1.71002873
140Oligomenorrhea (HP:0000876)1.70896699
141Ectopia lentis (HP:0001083)1.70507181
142Abnormality of the vitamin B12 metabolism (HP:0004341)1.68349911
143Carpal bone hypoplasia (HP:0001498)1.67192273
144Wide nose (HP:0000445)1.63918084
145Abnormality of small intestinal villus morphology (HP:0011472)1.61419914
146Villous atrophy (HP:0011473)1.61419914
147Spastic diplegia (HP:0001264)1.61153072
148Choanal stenosis (HP:0000452)1.60765034
149Abnormality of vitamin B metabolism (HP:0004340)1.59646652
150Sensory axonal neuropathy (HP:0003390)1.58369005
151Macrocytic anemia (HP:0001972)1.50966088
152Abnormal cartilage morphology (HP:0002763)1.50437181
153Absent eyelashes (HP:0000561)1.49933311
154Optic nerve hypoplasia (HP:0000609)1.49801343
155Oral leukoplakia (HP:0002745)1.49335618
156Clitoromegaly (HP:0000057)1.48495183
157Biliary tract neoplasm (HP:0100574)1.46171307
158Septo-optic dysplasia (HP:0100842)1.43683351
159Congenital, generalized hypertrichosis (HP:0004540)1.43662650
160Abnormality of vitamin metabolism (HP:0100508)1.42931776
161Sparse eyelashes (HP:0000653)1.42783731
162Abdominal pain (HP:0002027)1.42435014
163Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.40918045
164Medulloblastoma (HP:0002885)1.38344182
165Hydroxyprolinuria (HP:0003080)1.37611127
166Abnormality of proline metabolism (HP:0010907)1.37611127
167Abnormal hair whorl (HP:0010721)1.35659185
168Popliteal pterygium (HP:0009756)1.34264112
169Hypoplastic labia majora (HP:0000059)1.33691235
170Pterygium (HP:0001059)1.33328477
171IgM deficiency (HP:0002850)1.33212915
172Sex reversal (HP:0012245)1.31915272
173Abnormal sex determination (HP:0012244)1.31915272
174Intrahepatic cholestasis (HP:0001406)1.29774531
175Volvulus (HP:0002580)1.28641875
176Palpitations (HP:0001962)1.27635365
177Hypoplastic female external genitalia (HP:0012815)1.26787093
178Glossoptosis (HP:0000162)1.26196862
179Scrotal hypoplasia (HP:0000046)1.25904905
180Rhabdomyosarcoma (HP:0002859)1.25668932
181Papillary thyroid carcinoma (HP:0002895)1.25218350
182Labial hypoplasia (HP:0000066)1.24622097
183Nonprogressive disorder (HP:0003680)1.23434715
184Lower limb hyperreflexia (HP:0002395)1.23177756
185Abnormality of the clitoris (HP:0000056)1.21288305
186Late onset (HP:0003584)1.20744739
187Ovarian neoplasm (HP:0100615)1.20099561

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.62285327
2ERN14.50053306
3TAOK33.87298320
4GRK13.84313377
5TRIB33.41675030
6MYLK3.29809054
7EPHA23.09077954
8FRK2.82588309
9STK162.79093795
10INSRR2.64516001
11PKN22.42406825
12SRPK12.37910731
13MAPKAPK32.32197991
14PAK22.26375056
15MAP2K22.25429966
16TSSK62.21894465
17TTN2.18152701
18EIF2AK12.10119824
19IRAK32.08163176
20SIK11.91125016
21ADRBK21.90623513
22PIK3CG1.86835142
23MKNK21.86515792
24VRK21.81350970
25EIF2AK31.81019539
26PASK1.80884255
27BUB11.79239761
28NLK1.78770209
29WNK41.78669868
30LMTK21.72561001
31MAP3K31.71544930
32TTK1.70714259
33BRSK21.69830308
34STK38L1.66646139
35LATS11.63544055
36MAP3K121.63187004
37AKT31.61834563
38TAF11.59893171
39MKNK11.53001023
40TGFBR21.51851225
41BMPR1B1.51236904
42ACVR1B1.49445595
43PLK31.47859603
44STK241.44134867
45TNIK1.43516808
46CDC71.34768844
47RIPK11.32262164
48PDGFRA1.32095362
49PRKG21.29889848
50EPHB11.28106625
51FER1.26376737
52OXSR11.25748297
53FGFR21.24970161
54MST41.19810646
55EEF2K1.19805421
56PDK21.18098794
57DDR21.17960365
58IRAK21.14954773
59NUAK11.14241874
60LRRK21.14234467
61MAP2K11.13428183
62NEK11.12327309
63MAP3K21.09834051
64PTK61.08657167
65VRK11.06997707
66CAMK1D1.05965614
67CDK191.00460393
68PTK21.00095368
69ERBB40.99939867
70STK30.97639444
71PDGFRB0.96140842
72RPS6KB20.93669844
73EIF2AK20.93506007
74DMPK0.90470309
75MST1R0.90042205
76RET0.89092151
77MELK0.86217479
78ZAP700.85222758
79FLT30.80794675
80TRIM280.80302429
81ALK0.78208191
82PRKCZ0.78005742
83SCYL20.77885423
84MET0.77865319
85CSNK1G10.75398549
86PIK3CA0.74310409
87IRAK10.74078197
88BMX0.73095882
89CAMK1G0.73067567
90BRD40.72028627
91PRKD30.72012407
92PLK10.70184894
93NTRK10.69728314
94PDPK10.69652775
95MAP3K40.65705330
96PAK30.65021151
97DAPK10.64822698
98CDC42BPA0.64734660
99MTOR0.64665891
100ZAK0.64060942
101CDK80.62350344
102PRKCH0.62079624
103PRKCI0.61372579
104TESK10.60890888
105PBK0.60408709
106FGFR40.59771650
107JAK20.59107798
108DAPK30.59106934
109DAPK20.59091846
110PRKCE0.58625959
111STK380.55757359
112PAK40.55094240
113MATK0.54568739
114DYRK20.53901742
115ERBB30.53584679
116MAP2K40.53527022
117DYRK1B0.52959328
118ILK0.52887533
119PDK10.51575805
120MAP3K50.50983983
121BRSK10.50932402
122EPHA30.49291799
123ATM0.49108178
124JAK10.48977916
125EGFR0.48337610
126MAPK120.47614177
127PTK2B0.46551283
128MAP3K70.46511185
129ERBB20.45247658
130PLK40.44921190
131TIE10.44865514
132CDK90.44198643
133WNK30.43038203
134WNK10.41005028
135PRKD10.39975124
136PDK40.37868437
137PDK30.37868437
138STK390.36970820
139CSNK1E0.36731546
140CAMKK10.36409431
141CSNK2A10.36205909
142DYRK1A0.35948992
143SRC0.33983267
144JAK30.33679527
145AURKB0.32786391
146IRAK40.32743368
147YES10.32419978
148TYRO30.32331915
149PRKACB0.32256091
150NEK60.31857997
151NME10.30658668
152GSK3A0.30337255
153FGFR10.30182866
154FYN0.29136348
155MAPK30.29005716
156IGF1R0.28929336
157NTRK30.28719096
158ATR0.28613984
159GRK60.27363225
160ROCK10.27174631
161BCR0.26827372
162MAP3K60.25981738
163CSNK1G30.25587492
164CSNK2A20.25259345
165PRKDC0.24842263
166ABL10.23974222
167PHKG20.22537839
168BMPR20.21456345
169STK100.19038730
170CHEK10.18493130
171CDK30.18403236
172MAP3K80.17417451
173CSNK1A10.16802007
174TRPM70.16167577
175TEC0.15714135
176MAP3K90.14372102

Predicted pathways (KEGG)

RankGene SetZ-score
1Pancreatic secretion_Homo sapiens_hsa049725.35568741
2Fat digestion and absorption_Homo sapiens_hsa049754.32941958
3Protein digestion and absorption_Homo sapiens_hsa049744.20969327
4Glycerolipid metabolism_Homo sapiens_hsa005612.98965766
5Other glycan degradation_Homo sapiens_hsa005112.38731399
6Nitrogen metabolism_Homo sapiens_hsa009102.34631994
7Vitamin digestion and absorption_Homo sapiens_hsa049772.23748454
8Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.23595587
9ABC transporters_Homo sapiens_hsa020102.23418293
10Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.21783712
11Cyanoamino acid metabolism_Homo sapiens_hsa004602.00400062
12Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.86437876
13Propanoate metabolism_Homo sapiens_hsa006401.72519451
14Sulfur metabolism_Homo sapiens_hsa009201.71512183
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.67877535
16Fatty acid degradation_Homo sapiens_hsa000711.67271208
17Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.56884494
18alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56216753
19Protein export_Homo sapiens_hsa030601.56182713
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.49485098
212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.48739501
22Steroid biosynthesis_Homo sapiens_hsa001001.44564000
23Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.41343611
24Fatty acid metabolism_Homo sapiens_hsa012121.34718038
25Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.31834088
26Folate biosynthesis_Homo sapiens_hsa007901.29974097
27PPAR signaling pathway_Homo sapiens_hsa033201.29940790
28Lysosome_Homo sapiens_hsa041421.24679226
29Primary bile acid biosynthesis_Homo sapiens_hsa001201.21399337
30Maturity onset diabetes of the young_Homo sapiens_hsa049501.21136855
31Complement and coagulation cascades_Homo sapiens_hsa046101.19311395
32Ether lipid metabolism_Homo sapiens_hsa005651.18661468
33Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.17750984
34Proteasome_Homo sapiens_hsa030501.14190244
35Arachidonic acid metabolism_Homo sapiens_hsa005901.10150486
36Thyroid hormone synthesis_Homo sapiens_hsa049181.08568123
37Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06980180
38Glutathione metabolism_Homo sapiens_hsa004801.03813349
39Renin-angiotensin system_Homo sapiens_hsa046141.01532356
40Arginine biosynthesis_Homo sapiens_hsa002201.01304005
41Biosynthesis of amino acids_Homo sapiens_hsa012301.00488532
42Glycosaminoglycan degradation_Homo sapiens_hsa005310.94171389
43Arginine and proline metabolism_Homo sapiens_hsa003300.92377611
44beta-Alanine metabolism_Homo sapiens_hsa004100.91059085
45Starch and sucrose metabolism_Homo sapiens_hsa005000.90599181
46Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87808179
47Tryptophan metabolism_Homo sapiens_hsa003800.86945400
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.83639491
49Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.81291816
50Prion diseases_Homo sapiens_hsa050200.79680306
51Salivary secretion_Homo sapiens_hsa049700.75081413
52Pyruvate metabolism_Homo sapiens_hsa006200.73793472
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.71921925
54ECM-receptor interaction_Homo sapiens_hsa045120.70964260
55Staphylococcus aureus infection_Homo sapiens_hsa051500.70413073
56Non-homologous end-joining_Homo sapiens_hsa034500.69059667
57Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68960869
58Bile secretion_Homo sapiens_hsa049760.66756891
59Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.66098627
60Carbon metabolism_Homo sapiens_hsa012000.63650602
61Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.62341393
62RNA polymerase_Homo sapiens_hsa030200.61435051
63N-Glycan biosynthesis_Homo sapiens_hsa005100.60148834
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.58989532
65Linoleic acid metabolism_Homo sapiens_hsa005910.58827876
66Vascular smooth muscle contraction_Homo sapiens_hsa042700.57416981
67Ribosome_Homo sapiens_hsa030100.56201296
68Vibrio cholerae infection_Homo sapiens_hsa051100.55848708
69Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.55801328
70Chemical carcinogenesis_Homo sapiens_hsa052040.53946232
71Mismatch repair_Homo sapiens_hsa034300.52841663
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.52086765
73Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47994857
74Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.47052697
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.46536717
76RNA transport_Homo sapiens_hsa030130.45831613
77Gastric acid secretion_Homo sapiens_hsa049710.45551392
78Sphingolipid metabolism_Homo sapiens_hsa006000.44786997
79Mineral absorption_Homo sapiens_hsa049780.44764034
80Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.44055115
81Amoebiasis_Homo sapiens_hsa051460.43191789
82Fatty acid biosynthesis_Homo sapiens_hsa000610.42634057
83Regulation of autophagy_Homo sapiens_hsa041400.41875775
84Circadian rhythm_Homo sapiens_hsa047100.40265837
85Tyrosine metabolism_Homo sapiens_hsa003500.38754172
86Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38224920
87Selenocompound metabolism_Homo sapiens_hsa004500.38137864
88Vitamin B6 metabolism_Homo sapiens_hsa007500.38122096
89Phenylalanine metabolism_Homo sapiens_hsa003600.36717788
90DNA replication_Homo sapiens_hsa030300.36702298
91Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.35769265
92Renin secretion_Homo sapiens_hsa049240.35072233
93Peroxisome_Homo sapiens_hsa041460.34885098
94Adipocytokine signaling pathway_Homo sapiens_hsa049200.34010380
95Focal adhesion_Homo sapiens_hsa045100.33866041
96Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.33637020
97Toxoplasmosis_Homo sapiens_hsa051450.31693040
98Influenza A_Homo sapiens_hsa051640.31389877
99Insulin secretion_Homo sapiens_hsa049110.28787832
100Tight junction_Homo sapiens_hsa045300.28610032
101Retinol metabolism_Homo sapiens_hsa008300.27999657
102Steroid hormone biosynthesis_Homo sapiens_hsa001400.27747325
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.27350236
104Glycerophospholipid metabolism_Homo sapiens_hsa005640.26365061
105Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.25957582
106Insulin resistance_Homo sapiens_hsa049310.24847544
107Adherens junction_Homo sapiens_hsa045200.23325411
108RNA degradation_Homo sapiens_hsa030180.22988153
109Spliceosome_Homo sapiens_hsa030400.21925692
110Caffeine metabolism_Homo sapiens_hsa002320.21322213
111Pancreatic cancer_Homo sapiens_hsa052120.20078931
112Calcium signaling pathway_Homo sapiens_hsa040200.19482201
113Rheumatoid arthritis_Homo sapiens_hsa053230.19480063
114Pentose phosphate pathway_Homo sapiens_hsa000300.18717195
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18689096
116Metabolic pathways_Homo sapiens_hsa011000.17971604
117One carbon pool by folate_Homo sapiens_hsa006700.17876858
118Histidine metabolism_Homo sapiens_hsa003400.17109603
119Dilated cardiomyopathy_Homo sapiens_hsa054140.17013743
120Notch signaling pathway_Homo sapiens_hsa043300.16839453
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.16789088
122Basal transcription factors_Homo sapiens_hsa030220.16137002
123Base excision repair_Homo sapiens_hsa034100.12862259
124Fatty acid elongation_Homo sapiens_hsa000620.12342209
125Homologous recombination_Homo sapiens_hsa034400.12179680
126Cell cycle_Homo sapiens_hsa041100.11660126
127Thyroid cancer_Homo sapiens_hsa052160.11586622
128Pyrimidine metabolism_Homo sapiens_hsa002400.10322688
129Oxidative phosphorylation_Homo sapiens_hsa001900.10289558
130mRNA surveillance pathway_Homo sapiens_hsa030150.09956603
131Nucleotide excision repair_Homo sapiens_hsa034200.06186538
132Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.06037005
133Purine metabolism_Homo sapiens_hsa002300.05686848
134Parkinsons disease_Homo sapiens_hsa050120.05598161
135Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.04688449
136Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.04395173
137Hepatitis C_Homo sapiens_hsa051600.02732707
138Butanoate metabolism_Homo sapiens_hsa006500.01278504
139Phototransduction_Homo sapiens_hsa047440.01200472
140Epstein-Barr virus infection_Homo sapiens_hsa051690.01075750
141Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.00326578
142Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.00184083
143TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0068421

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