ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit biogenesis (GO:0042274)	5.86176747
2	axon ensheathment in central nervous system (GO:0032291)	5.64172230
3	central nervous system myelination (GO:0022010)	5.64172230
4	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	5.20860436
5	viral transcription (GO:0019083)	5.06353324
6	protein neddylation (GO:0045116)	5.03685780
7	ATP synthesis coupled proton transport (GO:0015986)	4.97959497
8	energy coupled proton transport, down electrochemical gradient (GO:0015985)	4.97959497
9	translational termination (GO:0006415)	4.94429102
10	cotranslational protein targeting to membrane (GO:0006613)	4.64940383
11	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.58166721
12	protein targeting to ER (GO:0045047)	4.57444610
13	proteasome assembly (GO:0043248)	4.38995061
14	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.38390118
15	protein localization to endoplasmic reticulum (GO:0070972)	4.36896838
16	ribosomal small subunit assembly (GO:0000028)	4.30993689
17	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	4.30652285
18	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	4.24753480
19	ribosomal large subunit biogenesis (GO:0042273)	4.12135079
20	translational elongation (GO:0006414)	4.07296256
21	termination of RNA polymerase III transcription (GO:0006386)	4.05397444
22	transcription elongation from RNA polymerase III promoter (GO:0006385)	4.05397444
23	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.02064960
24	chaperone-mediated protein transport (GO:0072321)	4.00297127
25	cellular protein complex disassembly (GO:0043624)	3.98901062
26	translational initiation (GO:0006413)	3.97819688
27	maturation of SSU-rRNA (GO:0030490)	3.96093145
28	viral life cycle (GO:0019058)	3.95810554
29	7-methylguanosine mRNA capping (GO:0006370)	3.95606360
30	7-methylguanosine RNA capping (GO:0009452)	3.90543326
31	RNA capping (GO:0036260)	3.90543326
32	regulation of mitochondrial translation (GO:0070129)	3.89928197
33	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.88468427
34	fatty acid elongation (GO:0030497)	3.83200640
35	protein-cofactor linkage (GO:0018065)	3.75260099
36	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.73319350
37	NADH dehydrogenase complex assembly (GO:0010257)	3.73319350
38	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.73319350
39	negative regulation of ligase activity (GO:0051352)	3.73217419
40	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	3.73217419
41	respiratory electron transport chain (GO:0022904)	3.71789538
42	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.69172910
43	translation (GO:0006412)	3.68771197
44	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.67444750
45	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	3.63629659
46	electron transport chain (GO:0022900)	3.61615584
47	ATP biosynthetic process (GO:0006754)	3.61017851
48	inner mitochondrial membrane organization (GO:0007007)	3.58625351
49	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.57333906
50	hydrogen ion transmembrane transport (GO:1902600)	3.56037445
51	sequestering of actin monomers (GO:0042989)	3.53122323
52	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	3.52888373
53	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.49527249
54	regulation of cellular amino acid metabolic process (GO:0006521)	3.48487074
55	respiratory chain complex IV assembly (GO:0008535)	3.48249371
56	cytochrome complex assembly (GO:0017004)	3.46588899
57	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	3.46511400
58	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	3.45936357
59	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	3.40348831
60	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	3.40348831
61	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.40288912
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.39654301
63	ribonucleoprotein complex biogenesis (GO:0022613)	3.39514031
64	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	3.35221220
65	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	3.34118915
66	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	3.34118915
67	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	3.34118915
68	L-methionine salvage (GO:0071267)	3.32469428
69	L-methionine biosynthetic process (GO:0071265)	3.32469428
70	amino acid salvage (GO:0043102)	3.32469428
71	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	3.31234406
72	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	3.31234406
73	long-chain fatty acid biosynthetic process (GO:0042759)	3.27759940
74	signal transduction involved in DNA integrity checkpoint (GO:0072401)	3.27441463
75	signal transduction involved in DNA damage checkpoint (GO:0072422)	3.27441463
76	protein complex disassembly (GO:0043241)	3.25859899
77	DNA damage response, detection of DNA damage (GO:0042769)	3.22783721
78	transcription elongation from RNA polymerase I promoter (GO:0006362)	3.22580571
79	proton transport (GO:0015992)	3.22543904
80	signal transduction involved in cell cycle checkpoint (GO:0072395)	3.21545197
81	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	3.19571820
82	protein targeting to mitochondrion (GO:0006626)	3.19129583
83	chromatin remodeling at centromere (GO:0031055)	3.18617042
84	protein complex biogenesis (GO:0070271)	3.17418040
85	nuclear-transcribed mRNA catabolic process (GO:0000956)	3.17135911
86	neutrophil activation involved in immune response (GO:0002283)	3.16160251
87	hydrogen transport (GO:0006818)	3.15938265
88	transcription from RNA polymerase I promoter (GO:0006360)	3.14302621
89	intracellular protein transmembrane import (GO:0044743)	3.13375705
90	positive regulation of ligase activity (GO:0051351)	3.12977087
91	behavioral response to nicotine (GO:0035095)	3.12489292
92	cellular component biogenesis (GO:0044085)	3.11392201
93	rRNA modification (GO:0000154)	3.09989889
94	cullin deneddylation (GO:0010388)	3.08912083
95	macromolecular complex disassembly (GO:0032984)	3.08208979
96	establishment of protein localization to mitochondrion (GO:0072655)	3.07633189
97	transcription elongation from RNA polymerase II promoter (GO:0006368)	3.06982511
98	protein targeting to membrane (GO:0006612)	3.05826711
99	CENP-A containing nucleosome assembly (GO:0034080)	3.05662678
100	GTP biosynthetic process (GO:0006183)	3.01871562
101	termination of RNA polymerase I transcription (GO:0006363)	3.01783351
102	formation of translation preinitiation complex (GO:0001731)	3.01094949
103	cholesterol biosynthetic process (GO:0006695)	3.00175470
104	mRNA catabolic process (GO:0006402)	2.98235973
105	rRNA processing (GO:0006364)	2.96905106
106	protein deneddylation (GO:0000338)	2.96463430
107	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.94150161
108	ensheathment of neurons (GO:0007272)	2.92721307
109	axon ensheathment (GO:0008366)	2.92721307
110	epithelial cilium movement (GO:0003351)	2.92164248
111	regulation of ubiquitin-protein transferase activity (GO:0051438)	2.91647088
112	establishment of integrated proviral latency (GO:0075713)	2.90592403
113	protein localization to mitochondrion (GO:0070585)	2.90308918
114	positive regulation of transcription elongation from RNA polymerase II promoter (GO:0032968)	2.89539484
115	mitochondrial respiratory chain complex assembly (GO:0033108)	2.88963343
116	myelination (GO:0042552)	2.88179907
117	regulation of ligase activity (GO:0051340)	2.87364990
118	spliceosomal snRNP assembly (GO:0000387)	2.84935804
119	transcription-coupled nucleotide-excision repair (GO:0006283)	2.82100558
120	establishment of viral latency (GO:0019043)	2.81834228
121	rRNA metabolic process (GO:0016072)	2.81656778
122	mitochondrial transport (GO:0006839)	2.79962671
123	transcription initiation from RNA polymerase I promoter (GO:0006361)	2.79565566
124	positive regulation of viral transcription (GO:0050434)	2.78696407
125	regulation of cilium movement (GO:0003352)	2.78480587
126	DNA-templated transcription, elongation (GO:0006354)	2.77998874
127	microtubule polymerization or depolymerization (GO:0031109)	2.77591165
128	spliceosomal complex assembly (GO:0000245)	2.75933042
129	pseudouridine synthesis (GO:0001522)	2.75722134
130	histone exchange (GO:0043486)	2.75287995
131	nucleoside triphosphate biosynthetic process (GO:0009142)	2.74966686
132	water-soluble vitamin biosynthetic process (GO:0042364)	2.73913423
133	organelle disassembly (GO:1903008)	2.71888338
134	RNA catabolic process (GO:0006401)	2.71159124
135	oxidative phosphorylation (GO:0006119)	2.69742970
136	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.68937341
137	nonmotile primary cilium assembly (GO:0035058)	2.67251359
138	platelet dense granule organization (GO:0060155)	2.67173322
139	DNA double-strand break processing (GO:0000729)	2.64813025

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	6.02427591
2	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	5.07108067
3	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.77473404
4	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.62486678
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	4.21955617
6	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.80022650
7	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	3.78110577
8	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	3.65228530
9	* JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.50895029
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.45241081
11	MYC_18555785_ChIP-Seq_MESCs_Mouse	3.40327407
12	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.08117034
13	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.89957529
14	VDR_23849224_ChIP-Seq_CD4+_Human	2.66032128
15	ELF1_17652178_ChIP-ChIP_JURKAT_Human	2.63012934
16	ELK1_19687146_ChIP-ChIP_HELA_Human	2.59455354
17	E2F7_22180533_ChIP-Seq_HELA_Human	2.57883180
18	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.52003531
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.37839759
20	EZH2_22144423_ChIP-Seq_EOC_Human	2.31933603
21	MYC_19079543_ChIP-ChIP_MESCs_Mouse	2.31667168
22	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	2.31087738
23	MYC_19030024_ChIP-ChIP_MESCs_Mouse	2.30972713
24	DCP1A_22483619_ChIP-Seq_HELA_Human	2.28455065
25	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.23227035
26	ZNF274_21170338_ChIP-Seq_K562_Hela	2.22132002
27	XRN2_22483619_ChIP-Seq_HELA_Human	2.21694485
28	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	2.05288306
29	E2F4_17652178_ChIP-ChIP_JURKAT_Human	2.04354111
30	E2F1_18555785_ChIP-Seq_MESCs_Mouse	2.04055129
31	FOXP3_21729870_ChIP-Seq_TREG_Human	2.01383486
32	SRF_21415370_ChIP-Seq_HL-1_Mouse	1.91451644
33	FUS_26573619_Chip-Seq_HEK293_Human	1.90950834
34	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.89928352
35	EWS_26573619_Chip-Seq_HEK293_Human	1.87647950
36	IGF1R_20145208_ChIP-Seq_DFB_Human	1.82880582
37	TTF2_22483619_ChIP-Seq_HELA_Human	1.80319984
38	HOXB4_20404135_ChIP-ChIP_EML_Mouse	1.79825935
39	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	1.73702085
40	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.68860564
41	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.66573726
42	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.66467982
43	* GABP_19822575_ChIP-Seq_HepG2_Human	1.66102932
44	THAP11_20581084_ChIP-Seq_MESCs_Mouse	1.65033549
45	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.59309762
46	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	1.57160100
47	AR_21909140_ChIP-Seq_LNCAP_Human	1.56128846
48	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.54084137
49	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.53650801
50	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	1.52797366
51	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.49969106
52	YY1_21170310_ChIP-Seq_MESCs_Mouse	1.49001467
53	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.47949802
54	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.42437444
55	FOXM1_23109430_ChIP-Seq_U2OS_Human	1.40586785
56	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.39389207
57	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	1.38238077
58	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	1.35383696
59	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.33901221
60	* ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.30458148
61	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.28399107
62	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.27499443
63	* P300_19829295_ChIP-Seq_ESCs_Human	1.26608196
64	MYC_18940864_ChIP-ChIP_HL60_Human	1.24005362
65	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.24005205
66	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.21587130
67	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.20611397
68	MYCN_18555785_ChIP-Seq_MESCs_Mouse	1.20584632
69	SOX17_20123909_ChIP-Seq_XEN_Mouse	1.19809009
70	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.18408062
71	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.18307943
72	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.17832421
73	TP53_22573176_ChIP-Seq_HFKS_Human	1.17507849
74	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.16347636
75	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.14450728
76	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.13677331
77	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.11871287
78	* SPI1_23547873_ChIP-Seq_NB4_Human	1.11623970
79	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.11447827
80	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.11235050
81	* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10798529
82	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.07195825
83	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	1.05455571
84	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05384317
85	NANOG_18555785_ChIP-Seq_MESCs_Mouse	1.04581099
86	TAF15_26573619_Chip-Seq_HEK293_Human	1.03756961
87	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.03066840
88	KDM5A_27292631_Chip-Seq_BREAST_Human	1.02431057
89	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.99778322
90	SOX2_18555785_ChIP-Seq_MESCs_Mouse	0.99456789
91	TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse	0.98805304
92	TFEB_21752829_ChIP-Seq_HELA_Human	0.98523866
93	RNF2_27304074_Chip-Seq_NSC_Mouse	0.96481120
94	IRF1_19129219_ChIP-ChIP_H3396_Human	0.96353237
95	HTT_18923047_ChIP-ChIP_STHdh_Human	0.94224816
96	CBP_20019798_ChIP-Seq_JUKART_Human	0.93795719
97	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	0.93795719
98	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	0.92659639
99	RBPJ_22232070_ChIP-Seq_NCS_Mouse	0.92372291
100	TP63_19390658_ChIP-ChIP_HaCaT_Human	0.91880344
101	GBX2_23144817_ChIP-Seq_PC3_Human	0.90852498
102	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90576601
103	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90576601
104	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	0.89908783
105	ER_23166858_ChIP-Seq_MCF-7_Human	0.89622031
106	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.89241902
107	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.88370725
108	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.87714547
109	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.87714547
110	VDR_22108803_ChIP-Seq_LS180_Human	0.86973332
111	KAP1_22055183_ChIP-Seq_ESCs_Mouse	0.86810374
112	NANOG_16153702_ChIP-ChIP_HESCs_Human	0.86417941
113	NCOR_22424771_ChIP-Seq_293T_Human	0.85792695
114	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	0.85527886
115	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.85130429
116	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.84878595
117	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.84520623
118	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.83843362
119	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	0.83759797
120	SOX2_18692474_ChIP-Seq_MEFs_Mouse	0.83025510
121	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.82480479
122	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	0.81066819
123	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.78894770
124	POU5F1_16153702_ChIP-ChIP_HESCs_Human	0.78648348
125	STAT4_19710469_ChIP-ChIP_TH1__Mouse	0.78401811
126	* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human	0.76524168
127	NANOG_18692474_ChIP-Seq_MEFs_Mouse	0.75665881
128	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	0.74094729
129	OCT4_18692474_ChIP-Seq_MEFs_Mouse	0.73102848
130	PPARD_23208498_ChIP-Seq_MDA-MB-231_Human	0.73049440
131	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	0.72307726
132	SOX2_16153702_ChIP-ChIP_HESCs_Human	0.71933375
133	* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.71721195
134	ELF5_23300383_ChIP-Seq_T47D_Human	0.71067934
135	HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse	0.69814739
136	SMAD4_19686287_ChIP-ChIP_HaCaT_Human	0.68829105
137	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.67660114
138	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	0.66800506
139	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	0.66800506
140	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	0.66800506
141	STAT1_20625510_ChIP-Seq_HELA_Human	0.66072879
142	ATF3_23680149_ChIP-Seq_GBM1-GSC_Human	0.66039732
143	KLF4_18555785_ChIP-Seq_MESCs_Mouse	0.65322756

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0000920_abnormal_myelination	3.44809201
2	MP0003136_yellow_coat_color	3.25212753
3	MP0003806_abnormal_nucleotide_metabolis	3.14993381
4	MP0001529_abnormal_vocalization	3.05866369
5	MP0003693_abnormal_embryo_hatching	3.04319565
6	MP0002837_dystrophic_cardiac_calcinosis	3.03591660
7	MP0004957_abnormal_blastocyst_morpholog	2.79658101
8	MP0003186_abnormal_redox_activity	2.69769463
9	MP0005451_abnormal_body_composition	2.69560417
10	MP0008932_abnormal_embryonic_tissue	2.52575982
11	MP0008260_abnormal_autophagy	2.51186499
12	MP0005408_hypopigmentation	2.42406620
13	MP0003718_maternal_effect	2.36838604
14	MP0008057_abnormal_DNA_replication	2.33608471
15	MP0001905_abnormal_dopamine_level	2.29881718
16	MP0008789_abnormal_olfactory_epithelium	2.28186918
17	MP0009379_abnormal_foot_pigmentation	2.24830744
18	MP0009333_abnormal_splenocyte_physiolog	2.21644446
19	MP0006082_CNS_inflammation	2.19591873
20	MP0003950_abnormal_plasma_membrane	2.18113014
21	MP0006072_abnormal_retinal_apoptosis	2.15031495
22	MP0001984_abnormal_olfaction	2.06909042
23	MP0003077_abnormal_cell_cycle	2.03341296
24	MP0000372_irregular_coat_pigmentation	2.03145078
25	MP0002148_abnormal_hypersensitivity_rea	1.93635872
26	MP0003787_abnormal_imprinting	1.92528864
27	MP0003121_genomic_imprinting	1.91739546
28	MP0010094_abnormal_chromosome_stability	1.90632996
29	MP0002653_abnormal_ependyma_morphology	1.89058805
30	MP0009785_altered_susceptibility_to	1.84893912
31	MP0005394_taste/olfaction_phenotype	1.84875639
32	MP0005499_abnormal_olfactory_system	1.84875639
33	MP0005000_abnormal_immune_tolerance	1.83354572
34	MP0006276_abnormal_autonomic_nervous	1.78429956
35	MP0001293_anophthalmia	1.77528514
36	MP0005671_abnormal_response_to	1.76535613
37	MP0003646_muscle_fatigue	1.70945085
38	MP0003315_abnormal_perineum_morphology	1.63525940
39	MP0002163_abnormal_gland_morphology	1.63191237
40	MP0002102_abnormal_ear_morphology	1.62298352
41	MP0005058_abnormal_lysosome_morphology	1.61378662
42	MP0003111_abnormal_nucleus_morphology	1.61354407
43	MP0005084_abnormal_gallbladder_morpholo	1.61036425
44	MP0003123_paternal_imprinting	1.60872482
45	MP0008058_abnormal_DNA_repair	1.60017140
46	MP0005171_absent_coat_pigmentation	1.58865465
47	MP0001835_abnormal_antigen_presentation	1.58574111
48	MP0003724_increased_susceptibility_to	1.56457783
49	MP0001542_abnormal_bone_strength	1.55209654
50	MP0003122_maternal_imprinting	1.55011788
51	MP0001727_abnormal_embryo_implantation	1.53009982
52	MP0008995_early_reproductive_senescence	1.48064766
53	MP0004381_abnormal_hair_follicle	1.44611401
54	MP0002132_abnormal_respiratory_system	1.41574637
55	MP0003011_delayed_dark_adaptation	1.41389944
56	MP0001968_abnormal_touch/_nociception	1.38483962
57	MP0002736_abnormal_nociception_after	1.38404610
58	MP0004145_abnormal_muscle_electrophysio	1.37032407
59	MP0000631_abnormal_neuroendocrine_gland	1.36095343
60	MP0005410_abnormal_fertilization	1.35196112
61	MP0005025_abnormal_response_to	1.34800518
62	MP0002272_abnormal_nervous_system	1.34684637
63	MP0009046_muscle_twitch	1.32668201
64	MP0005551_abnormal_eye_electrophysiolog	1.30818213
65	MP0005646_abnormal_pituitary_gland	1.30652122
66	MP0006036_abnormal_mitochondrial_physio	1.29386627
67	MP0002419_abnormal_innate_immunity	1.28950177
68	MP0005253_abnormal_eye_physiology	1.28800299
69	MP0003221_abnormal_cardiomyocyte_apopto	1.28534635
70	MP0004742_abnormal_vestibular_system	1.27941757
71	MP0002277_abnormal_respiratory_mucosa	1.27753392
72	MP0003656_abnormal_erythrocyte_physiolo	1.24578903
73	MP0002723_abnormal_immune_serum	1.24487432
74	MP0003436_decreased_susceptibility_to	1.21517656
75	MP0005389_reproductive_system_phenotype	1.21273190
76	MP0003690_abnormal_glial_cell	1.19768821
77	MP0001730_embryonic_growth_arrest	1.19249959
78	MP0004142_abnormal_muscle_tone	1.19200942
79	MP0008877_abnormal_DNA_methylation	1.19005554
80	MP0010030_abnormal_orbit_morphology	1.17119880
81	MP0002452_abnormal_antigen_presenting	1.16699727
82	MP0001188_hyperpigmentation	1.16439348
83	MP0006035_abnormal_mitochondrial_morpho	1.15755586
84	MP0000778_abnormal_nervous_system	1.14840272
85	MP0001346_abnormal_lacrimal_gland	1.14809732
86	MP0000049_abnormal_middle_ear	1.13865788
87	MP0001485_abnormal_pinna_reflex	1.11449084
88	MP0003786_premature_aging	1.10145550
89	MP0008007_abnormal_cellular_replicative	1.09774970
90	MP0004147_increased_porphyrin_level	1.08285813
91	MP0002420_abnormal_adaptive_immunity	1.08104698
92	MP0003890_abnormal_embryonic-extraembry	1.07988665
93	MP0009745_abnormal_behavioral_response	1.07726729
94	MP0005423_abnormal_somatic_nervous	1.07616878
95	MP0001819_abnormal_immune_cell	1.06605741
96	MP0001800_abnormal_humoral_immune	1.04935883
97	MP0002557_abnormal_social/conspecific_i	1.01979224
98	MP0000343_altered_response_to	1.00675952
99	MP0005164_abnormal_response_to	1.00010973
100	MP0002933_joint_inflammation	0.99316392
101	MP0003937_abnormal_limbs/digits/tail_de	0.98484396
102	MP0004133_heterotaxia	0.97811447
103	MP0005645_abnormal_hypothalamus_physiol	0.97012414
104	MP0003698_abnormal_male_reproductive	0.96227949
105	MP0000685_abnormal_immune_system	0.95652992
106	MP0002234_abnormal_pharynx_morphology	0.94672265
107	MP0002938_white_spotting	0.94533441
108	MP0008872_abnormal_physiological_respon	0.94080386
109	MP0002752_abnormal_somatic_nervous	0.94034207
110	MP0000653_abnormal_sex_gland	0.92757208
111	MP0004885_abnormal_endolymph	0.92526403
112	MP0001851_eye_inflammation	0.91930568
113	MP0004215_abnormal_myocardial_fiber	0.90958683
114	MP0001919_abnormal_reproductive_system	0.90324057
115	MP0002233_abnormal_nose_morphology	0.89831910
116	MP0000026_abnormal_inner_ear	0.89821804
117	MP0001486_abnormal_startle_reflex	0.89707288
118	MP0002184_abnormal_innervation	0.88613636
119	MP0001661_extended_life_span	0.88175022
120	MP0000716_abnormal_immune_system	0.87488614
121	MP0003938_abnormal_ear_development	0.87350288
122	MP0005195_abnormal_posterior_eye	0.87277124
123	MP0005391_vision/eye_phenotype	0.87071470
124	MP0002751_abnormal_autonomic_nervous	0.86682180
125	MP0003634_abnormal_glial_cell	0.85169727
126	MP0001533_abnormal_skeleton_physiology	0.84954751
127	MP0002095_abnormal_skin_pigmentation	0.84779540
128	MP0002572_abnormal_emotion/affect_behav	0.84750090
129	MP0001286_abnormal_eye_development	0.84038145
130	MP0009697_abnormal_copulation	0.83989770
131	MP0000383_abnormal_hair_follicle	0.83273033
132	MP0001790_abnormal_immune_system	0.83072171
133	MP0005387_immune_system_phenotype	0.83072171
134	MP0002282_abnormal_trachea_morphology	0.81893626
135	MP0003567_abnormal_fetal_cardiomyocyte	0.81268627
136	MP0002405_respiratory_system_inflammati	0.80546841
137	MP0003195_calcinosis	0.80133532
138	MP0002210_abnormal_sex_determination	0.80081991
139	MP0002067_abnormal_sensory_capabilities	0.79223531
140	MP0008875_abnormal_xenobiotic_pharmacok	0.78946212
141	MP0002734_abnormal_mechanical_nocicepti	0.77953595
142	MP0003448_altered_tumor_morphology	0.77635473
143	MP0000350_abnormal_cell_proliferation	0.77392874
144	MP0001970_abnormal_pain_threshold	0.77068828
145	MP0005379_endocrine/exocrine_gland_phen	0.76249035
146	MP0002429_abnormal_blood_cell	0.75366914
147	MP0001145_abnormal_male_reproductive	0.74316447
148	MP0009840_abnormal_foam_cell	0.72063569
149	MP0002160_abnormal_reproductive_system	0.71108268
150	MP0000750_abnormal_muscle_regeneration	0.70581770
151	MP0001986_abnormal_taste_sensitivity	0.69873637
152	MP0002398_abnormal_bone_marrow	0.69768249
153	MP0003880_abnormal_central_pattern	0.69177625
154	MP0002638_abnormal_pupillary_reflex	0.68999337
155	MP0001929_abnormal_gametogenesis	0.68991895
156	MP0000313_abnormal_cell_death	0.68747827
157	MP0000465_gastrointestinal_hemorrhage	0.67966974
158	MP0000689_abnormal_spleen_morphology	0.67838821
159	MP0006292_abnormal_olfactory_placode	0.66914065
160	MP0005310_abnormal_salivary_gland	0.66307187
161	MP0001845_abnormal_inflammatory_respons	0.64364569
162	MP0002722_abnormal_immune_system	0.64262319
163	MP0009250_abnormal_appendicular_skeleto	0.63467307

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Increased serum pyruvate (HP:0003542)	5.18311327
2	Abnormality of glycolysis (HP:0004366)	5.18311327
3	Acute necrotizing encephalopathy (HP:0006965)	4.91562249
4	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	4.72129604
5	Abnormality of cells of the erythroid lineage (HP:0012130)	4.47053616
6	Parakeratosis (HP:0001036)	4.46163906
7	Cerebral hypomyelination (HP:0006808)	4.27123309
8	Abnormal mitochondria in muscle tissue (HP:0008316)	4.21397396
9	Mitochondrial inheritance (HP:0001427)	4.17132436
10	Abnormal number of erythroid precursors (HP:0012131)	3.96579522
11	Progressive macrocephaly (HP:0004481)	3.95466419
12	Acute encephalopathy (HP:0006846)	3.92822154
13	Increased hepatocellular lipid droplets (HP:0006565)	3.64974645
14	3-Methylglutaconic aciduria (HP:0003535)	3.57619903
15	Hepatocellular necrosis (HP:0001404)	3.57157898
16	Increased CSF lactate (HP:0002490)	3.57043525
17	Renal Fanconi syndrome (HP:0001994)	3.44655710
18	Reticulocytopenia (HP:0001896)	3.42525636
19	Congenital ichthyosiform erythroderma (HP:0007431)	3.37704786
20	Macrocytic anemia (HP:0001972)	3.30294095
21	Leukodystrophy (HP:0002415)	3.25510155
22	Pancreatic fibrosis (HP:0100732)	3.16619952
23	Lipid accumulation in hepatocytes (HP:0006561)	3.12207825
24	Pancreatic cysts (HP:0001737)	3.11257531
25	Sensory axonal neuropathy (HP:0003390)	3.10587448
26	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.99912136
27	True hermaphroditism (HP:0010459)	2.95164940
28	Molar tooth sign on MRI (HP:0002419)	2.88289844
29	Abnormality of midbrain morphology (HP:0002418)	2.88289844
30	Respiratory failure (HP:0002878)	2.88205929
31	Exertional dyspnea (HP:0002875)	2.88038344
32	Hepatic necrosis (HP:0002605)	2.85869965
33	Hepatosplenomegaly (HP:0001433)	2.82302617
34	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	2.79449404
35	Decreased activity of mitochondrial respiratory chain (HP:0008972)	2.79449404
36	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.77868113
37	Medial flaring of the eyebrow (HP:0010747)	2.70998757
38	Stenosis of the external auditory canal (HP:0000402)	2.68802974
39	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.59005494
40	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.59005494
41	Cerebral edema (HP:0002181)	2.57228033
42	Pallor (HP:0000980)	2.55564058
43	Nephronophthisis (HP:0000090)	2.55364699
44	Congenital, generalized hypertrichosis (HP:0004540)	2.53033206
45	Hyperglycinemia (HP:0002154)	2.51576374
46	Methylmalonic acidemia (HP:0002912)	2.51211632
47	Abnormality of the labia minora (HP:0012880)	2.48941729
48	Birth length less than 3rd percentile (HP:0003561)	2.48472922
49	Breast hypoplasia (HP:0003187)	2.42657805
50	Exercise intolerance (HP:0003546)	2.35339788
51	Sclerocornea (HP:0000647)	2.35236541
52	Increased serum lactate (HP:0002151)	2.35007021
53	CNS hypomyelination (HP:0003429)	2.34504582
54	Glycosuria (HP:0003076)	2.32362364
55	Abnormality of urine glucose concentration (HP:0011016)	2.32362364
56	Abnormality of renal resorption (HP:0011038)	2.30085358
57	Optic disc pallor (HP:0000543)	2.29113914
58	Abnormal hemoglobin (HP:0011902)	2.28412168
59	Peripheral hypomyelination (HP:0007182)	2.27019355
60	Myokymia (HP:0002411)	2.25775791
61	Increased intramyocellular lipid droplets (HP:0012240)	2.25215495
62	Carpal bone hypoplasia (HP:0001498)	2.24770451
63	Respiratory difficulties (HP:0002880)	2.24727796
64	Rough bone trabeculation (HP:0100670)	2.23763604
65	Gait imbalance (HP:0002141)	2.21373025
66	Abnormality of placental membranes (HP:0011409)	2.18534822
67	Amniotic constriction ring (HP:0009775)	2.18534822
68	Methylmalonic aciduria (HP:0012120)	2.18498165
69	Congenital primary aphakia (HP:0007707)	2.17733750
70	Septo-optic dysplasia (HP:0100842)	2.17601039
71	Irregular epiphyses (HP:0010582)	2.16585166
72	Spastic paraparesis (HP:0002313)	2.15797611
73	Adrenal hypoplasia (HP:0000835)	2.14220848
74	Abnormality of the umbilical cord (HP:0010881)	2.11384276
75	Lethargy (HP:0001254)	2.11304840
76	Secondary amenorrhea (HP:0000869)	2.10418148
77	Hypoplasia of the capital femoral epiphysis (HP:0003090)	2.10361272
78	Absent septum pellucidum (HP:0001331)	2.09583800
79	Abnormality of the fetal cardiovascular system (HP:0010948)	2.08274356
80	Abnormal umbilical cord blood vessels (HP:0011403)	2.08274356
81	Single umbilical artery (HP:0001195)	2.08274356
82	Nephrogenic diabetes insipidus (HP:0009806)	2.07036601
83	Abnormality of the septum pellucidum (HP:0007375)	2.05930023
84	Postnatal microcephaly (HP:0005484)	2.05718851
85	Prolonged neonatal jaundice (HP:0006579)	2.04109160
86	Lactic acidosis (HP:0003128)	2.02901871
87	Metaphyseal dysplasia (HP:0100255)	2.01250891
88	Male pseudohermaphroditism (HP:0000037)	2.01188218
89	Abnormality of macrophages (HP:0004311)	2.00523860
90	Erythroderma (HP:0001019)	2.00052962
91	Segmental peripheral demyelination/remyelination (HP:0003481)	1.98930323
92	Colon cancer (HP:0003003)	1.98619603
93	Abnormality of the renal medulla (HP:0100957)	1.98531943
94	Reduced antithrombin III activity (HP:0001976)	1.96031128
95	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.95366681
96	Anencephaly (HP:0002323)	1.95105188
97	Hypoplastic pelvis (HP:0008839)	1.94534304
98	Absent thumb (HP:0009777)	1.93142521
99	Aplastic anemia (HP:0001915)	1.91915587
100	Hyperphosphaturia (HP:0003109)	1.91808108
101	Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)	1.91528334
102	Absent epiphyses (HP:0010577)	1.91528334
103	Recurrent abscess formation (HP:0002722)	1.90898653
104	Small epiphyses (HP:0010585)	1.90467424
105	Type II lissencephaly (HP:0007260)	1.90376369
106	Abnormal respiratory motile cilium physiology (HP:0012261)	1.88425411
107	Abnormal trabecular bone morphology (HP:0100671)	1.86610459
108	Abnormalities of placenta or umbilical cord (HP:0001194)	1.84094403
109	Muscle fiber splitting (HP:0003555)	1.82062744
110	CNS demyelination (HP:0007305)	1.82054493
111	Multiple enchondromatosis (HP:0005701)	1.81627542
112	Anophthalmia (HP:0000528)	1.81382683
113	Autoamputation (HP:0001218)	1.80669776
114	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.79753588
115	Abnormality of alanine metabolism (HP:0010916)	1.79753588
116	Hyperalaninemia (HP:0003348)	1.79753588
117	Neurofibrillary tangles (HP:0002185)	1.79316870
118	Genital tract atresia (HP:0001827)	1.79211273
119	Vaginal atresia (HP:0000148)	1.78237467
120	Aplasia/Hypoplasia involving the musculature (HP:0001460)	1.78128805
121	Conical tooth (HP:0000698)	1.77660764
122	Abnormal ciliary motility (HP:0012262)	1.76738239
123	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.76320395
124	Increased muscle lipid content (HP:0009058)	1.76163749
125	Optic nerve hypoplasia (HP:0000609)	1.75994837
126	Asplenia (HP:0001746)	1.73327190
127	Retinal dysplasia (HP:0007973)	1.73199814
128	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.72719815
129	X-linked dominant inheritance (HP:0001423)	1.72461235
130	Aplasia/hypoplasia of the uterus (HP:0008684)	1.72038582
131	Meckel diverticulum (HP:0002245)	1.71409862
132	Generalized aminoaciduria (HP:0002909)	1.71266004
133	Abnormality of the ileum (HP:0001549)	1.69749572
134	Abnormal respiratory motile cilium morphology (HP:0005938)	1.68781879
135	Abnormal respiratory epithelium morphology (HP:0012253)	1.68781879
136	Emotional lability (HP:0000712)	1.68598246
137	Nemaline bodies (HP:0003798)	1.68374198
138	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.68303710
139	Paralysis (HP:0003470)	1.67761616
140	Median cleft lip (HP:0000161)	1.67523382
141	Cleft eyelid (HP:0000625)	1.67295305
142	Poor head control (HP:0002421)	1.66843360
143	Recurrent bacterial skin infections (HP:0005406)	1.66831919
144	Hypoplasia of the uterus (HP:0000013)	1.65549190
145	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.64676423
146	Abnormal rod and cone electroretinograms (HP:0008323)	1.64436712
147	Delusions (HP:0000746)	1.64418138
148	Cystic liver disease (HP:0006706)	1.64082954
149	Type I transferrin isoform profile (HP:0003642)	1.63706348
150	Pendular nystagmus (HP:0012043)	1.62582228
151	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.62102406
152	Abnormal protein N-linked glycosylation (HP:0012347)	1.62102406
153	Abnormal protein glycosylation (HP:0012346)	1.62102406
154	Abnormal glycosylation (HP:0012345)	1.62102406
155	Pancytopenia (HP:0001876)	1.61883147
156	Chronic obstructive pulmonary disease (HP:0006510)	1.61651979
157	Obstructive lung disease (HP:0006536)	1.61651979
158	Cerebral hemorrhage (HP:0001342)	1.61116420
159	Vacuolated lymphocytes (HP:0001922)	1.59220591

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PBK	4.37159804
2	STK39	3.66307332
3	NME2	3.43305364
4	BUB1	3.37313006
5	VRK2	3.31589430
6	LIMK1	2.91561054
7	BCR	2.87312591
8	MST4	2.86315583
9	TESK2	2.82098674
10	PINK1	2.80609034
11	EIF2AK1	2.57575891
12	ZAK	2.51367810
13	OXSR1	2.30225939
14	PIM2	2.10152374
15	WEE1	2.04223254
16	STK16	2.02538337
17	ARAF	1.95300468
18	NUAK1	1.93214298
19	EIF2AK3	1.88132374
20	BCKDK	1.82586453
21	MAP2K7	1.81183839
22	TLK1	1.76164926
23	WNK3	1.70096683
24	MAP4K2	1.68860599
25	NME1	1.68641620
26	CASK	1.64976121
27	VRK1	1.56647684
28	DYRK2	1.46262317
29	CSNK1G3	1.43424928
30	MAP3K4	1.41140738
31	CDK19	1.38860652
32	SRPK1	1.35920251
33	MET	1.34060165
34	BLK	1.33923992
35	FRK	1.33894357
36	MKNK1	1.33691208
37	TNIK	1.28511570
38	PLK4	1.26670893
39	MAPKAPK5	1.25145926
40	NEK1	1.24644508
41	WNK4	1.24365536
42	TESK1	1.20154908
43	PKN1	1.16718190
44	GRK1	1.13973251
45	EPHB1	1.13228540
46	CSNK1G1	1.12589567
47	BMPR1B	1.12481925
48	DYRK3	1.11638489
49	PNCK	1.08119832
50	TRIM28	1.06875786
51	RPS6KA5	1.05754638
52	ABL2	1.03182146
53	TSSK6	1.02397206
54	CDC7	1.01552337
55	PLK2	1.00990900
56	CSNK1A1L	1.00978196
57	MAPK13	1.00646146
58	BRSK2	0.98464937
59	PAK1	0.95805342
60	MARK1	0.95410671
61	MAP3K12	0.94762598
62	BRAF	0.94116111
63	IRAK4	0.91700038
64	AURKA	0.90919305
65	TGFBR1	0.88953994
66	PRKCG	0.87775875
67	FGR	0.86627382
68	PDK2	0.84698693
69	MINK1	0.83389750
70	STK10	0.82564600
71	ILK	0.82239166
72	EPHB2	0.82046822
73	CDK3	0.81226611
74	ACVR1B	0.80266640
75	EIF2AK2	0.79946197
76	MUSK	0.79523313
77	PLK1	0.79495186
78	CLK1	0.79361414
79	PLK3	0.79263617
80	TXK	0.78801353
81	STK4	0.78737176
82	GRK7	0.77925559
83	IKBKB	0.76425027
84	TAF1	0.76083286
85	MKNK2	0.76047902
86	PHKG2	0.74265858
87	PHKG1	0.74265858
88	RPS6KA4	0.72809650
89	AURKB	0.72365506
90	ROCK2	0.70734637
91	ERBB4	0.70658103
92	CAMK2B	0.69938015
93	MARK3	0.68697268
94	KDR	0.68139591
95	EPHA4	0.64387784
96	MAP3K14	0.64281191
97	STK38L	0.64186257
98	CSNK1G2	0.63899088
99	CCNB1	0.63790348
100	MAPK15	0.62624048
101	IRAK2	0.62230290
102	LRRK2	0.61253726
103	MOS	0.58502815
104	CDK14	0.58424793
105	CSNK2A1	0.58163045
106	PASK	0.56775841
107	CSNK2A2	0.55840838
108	CHEK2	0.55831091
109	TEC	0.54955851
110	INSRR	0.53938939
111	UHMK1	0.53858452
112	ATR	0.53426804
113	TBK1	0.50222758
114	NEK2	0.49189214
115	CAMK2G	0.48933353
116	CSNK1A1	0.48265397
117	BMPR2	0.48053414
118	MYLK	0.47780788
119	CDK7	0.47672229
120	TIE1	0.47426667
121	CAMK2D	0.47410000
122	PIM1	0.46715135
123	CSNK1E	0.46577962
124	CDK8	0.46156859
125	MAP3K8	0.45600612
126	MAP4K1	0.45270841
127	ERBB3	0.44299680
128	PAK3	0.44133793
129	OBSCN	0.44031914
130	PRKACA	0.43251895
131	PIK3CA	0.42678780
132	ATM	0.42667125
133	PRKCQ	0.42596167
134	MELK	0.42321429
135	PRKCE	0.41884145
136	CDK18	0.41772494
137	CDK15	0.41491648
138	CDK11A	0.41010629
139	ADRBK2	0.40613792
140	MAP2K2	0.39978442
141	DAPK3	0.39890512
142	FGFR2	0.39361494
143	LYN	0.38486667
144	IRAK1	0.36315973
145	MAPKAPK2	0.35627732
146	TTK	0.35357229
147	TRPM7	0.35075063
148	LCK	0.34994640

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Ribosome_Homo sapiens_hsa03010	4.50360813
2	Proteasome_Homo sapiens_hsa03050	4.42159619
3	RNA polymerase_Homo sapiens_hsa03020	3.65428332
4	Oxidative phosphorylation_Homo sapiens_hsa00190	3.64367661
5	Protein export_Homo sapiens_hsa03060	3.21165154
6	Parkinsons disease_Homo sapiens_hsa05012	3.05047291
7	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	3.01702135
8	Huntingtons disease_Homo sapiens_hsa05016	2.31235670
9	Basal transcription factors_Homo sapiens_hsa03022	2.26265869
10	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	2.17310576
11	Alzheimers disease_Homo sapiens_hsa05010	2.14433899
12	* Spliceosome_Homo sapiens_hsa03040	2.11662910
13	Steroid biosynthesis_Homo sapiens_hsa00100	2.00449349
14	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.92404863
15	DNA replication_Homo sapiens_hsa03030	1.92257567
16	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.82802689
17	Nucleotide excision repair_Homo sapiens_hsa03420	1.80911527
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.79917984
19	Homologous recombination_Homo sapiens_hsa03440	1.74571326
20	Mismatch repair_Homo sapiens_hsa03430	1.68266421
21	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.67079021
22	Fatty acid elongation_Homo sapiens_hsa00062	1.65679960
23	RNA transport_Homo sapiens_hsa03013	1.54500270
24	Ether lipid metabolism_Homo sapiens_hsa00565	1.52164260
25	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.51810557
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43209913
27	Propanoate metabolism_Homo sapiens_hsa00640	1.38021004
28	Glutathione metabolism_Homo sapiens_hsa00480	1.22396958
29	Non-homologous end-joining_Homo sapiens_hsa03450	1.21500950
30	Graft-versus-host disease_Homo sapiens_hsa05332	1.18892843
31	Rheumatoid arthritis_Homo sapiens_hsa05323	1.17995222
32	Phototransduction_Homo sapiens_hsa04744	1.16920681
33	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.12899798
34	Base excision repair_Homo sapiens_hsa03410	1.12780625
35	Cell cycle_Homo sapiens_hsa04110	1.12416314
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.10644284
37	Purine metabolism_Homo sapiens_hsa00230	1.07589151
38	Butanoate metabolism_Homo sapiens_hsa00650	1.07473388
39	Pyruvate metabolism_Homo sapiens_hsa00620	1.05873640
40	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.02762904
41	Allograft rejection_Homo sapiens_hsa05330	0.99817772
42	RNA degradation_Homo sapiens_hsa03018	0.98625403
43	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.95957509
44	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.95912942
45	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.94758426
46	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.93764636
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93503102
48	Asthma_Homo sapiens_hsa05310	0.88722735
49	Peroxisome_Homo sapiens_hsa04146	0.88657450
50	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.88034978
51	Nitrogen metabolism_Homo sapiens_hsa00910	0.86576448
52	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.85664485
53	Folate biosynthesis_Homo sapiens_hsa00790	0.85658046
54	Sulfur metabolism_Homo sapiens_hsa00920	0.83376544
55	Malaria_Homo sapiens_hsa05144	0.82045812
56	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.81106107
57	Nicotine addiction_Homo sapiens_hsa05033	0.79289751
58	Fanconi anemia pathway_Homo sapiens_hsa03460	0.78543845
59	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.78465508
60	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.75796296
61	Cardiac muscle contraction_Homo sapiens_hsa04260	0.75036713
62	Phagosome_Homo sapiens_hsa04145	0.74808876
63	Regulation of autophagy_Homo sapiens_hsa04140	0.73953922
64	Pentose phosphate pathway_Homo sapiens_hsa00030	0.73699285
65	Selenocompound metabolism_Homo sapiens_hsa00450	0.73655779
66	NOD-like receptor signaling pathway_Homo sapiens_hsa04621	0.72773117
67	Collecting duct acid secretion_Homo sapiens_hsa04966	0.72493746
68	Sphingolipid metabolism_Homo sapiens_hsa00600	0.71438464
69	Olfactory transduction_Homo sapiens_hsa04740	0.70465245
70	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.66289860
71	Tryptophan metabolism_Homo sapiens_hsa00380	0.64154070
72	p53 signaling pathway_Homo sapiens_hsa04115	0.64077716
73	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62583034
74	Legionellosis_Homo sapiens_hsa05134	0.62076462
75	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.61747437
76	Metabolic pathways_Homo sapiens_hsa01100	0.61338783
77	Arginine and proline metabolism_Homo sapiens_hsa00330	0.60215069
78	Histidine metabolism_Homo sapiens_hsa00340	0.56233559
79	Sulfur relay system_Homo sapiens_hsa04122	0.54449524
80	Shigellosis_Homo sapiens_hsa05131	0.52537376
81	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.52434626
82	Vibrio cholerae infection_Homo sapiens_hsa05110	0.51881912
83	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.51607645
84	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.50406684
85	Primary immunodeficiency_Homo sapiens_hsa05340	0.48848249
86	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.48835845
87	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.45642869
88	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.45212549
89	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.45118340
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.43466652
91	Antigen processing and presentation_Homo sapiens_hsa04612	0.43330742
92	Caffeine metabolism_Homo sapiens_hsa00232	0.43271605
93	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.43164316
94	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.42400601
95	Taste transduction_Homo sapiens_hsa04742	0.41947006
96	Herpes simplex infection_Homo sapiens_hsa05168	0.40259520
97	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.39056744
98	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.38348610
99	One carbon pool by folate_Homo sapiens_hsa00670	0.37880879
100	Viral carcinogenesis_Homo sapiens_hsa05203	0.37813585
101	Pertussis_Homo sapiens_hsa05133	0.36913429
102	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.36658110
103	Retinol metabolism_Homo sapiens_hsa00830	0.35987406
104	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.35829188
105	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.35527732
106	mRNA surveillance pathway_Homo sapiens_hsa03015	0.35460335
107	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.34224924
108	Chemical carcinogenesis_Homo sapiens_hsa05204	0.34147722
109	Salmonella infection_Homo sapiens_hsa05132	0.33920207
110	Lysosome_Homo sapiens_hsa04142	0.32847964
111	Basal cell carcinoma_Homo sapiens_hsa05217	0.32763334
112	beta-Alanine metabolism_Homo sapiens_hsa00410	0.32192660
113	GABAergic synapse_Homo sapiens_hsa04727	0.31671928
114	Tyrosine metabolism_Homo sapiens_hsa00350	0.31387103
115	Mineral absorption_Homo sapiens_hsa04978	0.31101044
116	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.29922990
117	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.27186702
118	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.27131605
119	Carbon metabolism_Homo sapiens_hsa01200	0.26001615
120	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.24357797
121	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.23854621
122	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.22923507
123	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.22782071
124	Leishmaniasis_Homo sapiens_hsa05140	0.22013860
125	Morphine addiction_Homo sapiens_hsa05032	0.21271265
126	Fatty acid degradation_Homo sapiens_hsa00071	0.20951916
127	Insulin secretion_Homo sapiens_hsa04911	0.19532189
128	Type I diabetes mellitus_Homo sapiens_hsa04940	0.19453248
129	Measles_Homo sapiens_hsa05162	0.19096614
130	Alcoholism_Homo sapiens_hsa05034	0.18318856
131	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.17205328
132	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.17197625
133	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.16814317
134	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	0.15060935
135	Renal cell carcinoma_Homo sapiens_hsa05211	0.13883487
136	Apoptosis_Homo sapiens_hsa04210	0.12925943
137	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.10838507
138	Oocyte meiosis_Homo sapiens_hsa04114	0.10754573
139	Phenylalanine metabolism_Homo sapiens_hsa00360	0.10711466

CWC15

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »