CWC25

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a factor that is part of the multi-protein C complex involved in pre-mRNA splicing. Alternatively spliced transcripts have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1daunorubicin metabolic process (GO:0044597)9.47282668
2polyketide metabolic process (GO:0030638)9.47282668
3doxorubicin metabolic process (GO:0044598)9.47282668
4interferon-gamma production (GO:0032609)6.40153511
5aminoglycoside antibiotic metabolic process (GO:0030647)5.78195862
6regulation of nuclear cell cycle DNA replication (GO:0033262)5.58048808
7regulation of mammary gland epithelial cell proliferation (GO:0033599)5.48672295
8maintenance of protein location in nucleus (GO:0051457)5.39250471
9regulation of telomere maintenance via telomerase (GO:0032210)5.03423652
10somite rostral/caudal axis specification (GO:0032525)4.93715957
11protein localization to kinetochore (GO:0034501)4.83001401
12negative regulation of epidermis development (GO:0045683)4.54614541
13regulation of MHC class I biosynthetic process (GO:0045343)4.49232155
14histone H4-K12 acetylation (GO:0043983)4.45679617
15negative regulation of telomere maintenance (GO:0032205)4.30283215
16negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)4.21650680
17rRNA transcription (GO:0009303)4.21129014
18muscle organ morphogenesis (GO:0048644)4.19918099
19rRNA methylation (GO:0031167)4.15476038
20negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)4.15373869
21negative regulation of T-helper cell differentiation (GO:0045623)4.15373869
22regulation of cilium movement (GO:0003352)3.97821793
23regulation of response to osmotic stress (GO:0047484)3.93346782
24negative regulation of cell cycle G2/M phase transition (GO:1902750)3.89443414
25negative regulation of epidermal cell differentiation (GO:0045605)3.86783031
26rRNA modification (GO:0000154)3.85799505
27histone H4-K5 acetylation (GO:0043981)3.84287219
28histone H4-K8 acetylation (GO:0043982)3.84287219
29positive regulation of defense response to virus by host (GO:0002230)3.81879362
30negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.81629531
31positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.77441512
32piRNA metabolic process (GO:0034587)3.68236874
33DNA deamination (GO:0045006)3.63988396
34DNA replication checkpoint (GO:0000076)3.63157113
35protein localization to chromosome, centromeric region (GO:0071459)3.61221279
36cell fate commitment involved in formation of primary germ layer (GO:0060795)3.58181091
37negative regulation of telomerase activity (GO:0051974)3.55764230
38branching involved in mammary gland duct morphogenesis (GO:0060444)3.53757923
39positive regulation of DNA-dependent DNA replication (GO:2000105)3.45773305
40centriole replication (GO:0007099)3.45231035
41tolerance induction (GO:0002507)3.42693541
42regulation of telomere maintenance (GO:0032204)3.42217426
43cell wall macromolecule catabolic process (GO:0016998)3.42090323
44mitotic sister chromatid segregation (GO:0000070)3.40984741
45positive regulation of gamma-delta T cell activation (GO:0046645)3.39190654
46protein K11-linked deubiquitination (GO:0035871)3.33856431
47phenol-containing compound catabolic process (GO:0019336)3.28696604
48negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.23376978
49regulation of gamma-delta T cell activation (GO:0046643)3.19163352
50cytidine metabolic process (GO:0046087)3.14224060
51cytidine catabolic process (GO:0006216)3.14224060
52cytidine deamination (GO:0009972)3.14224060
53regulation of T-helper cell differentiation (GO:0045622)3.14160254
54regulation of T-helper 1 cell differentiation (GO:0045625)3.12840797
55cell wall macromolecule metabolic process (GO:0044036)3.11935668
56multicellular organism reproduction (GO:0032504)3.10466265
57regulation of apoptotic process involved in morphogenesis (GO:1902337)3.08744677
58response to dietary excess (GO:0002021)3.08455908
59RNA destabilization (GO:0050779)3.08089524
60regulation of T-helper 2 cell differentiation (GO:0045628)3.07500718
61response to peptidoglycan (GO:0032494)3.06594595
62positive regulation of T-helper 1 type immune response (GO:0002827)3.04702171
63nuclear pore complex assembly (GO:0051292)3.04317010
64antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.04296875
65negative regulation of interleukin-1 beta production (GO:0032691)3.04114762
66regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.03778971
67negative regulation of alpha-beta T cell differentiation (GO:0046639)3.02797330
68notochord development (GO:0030903)3.01872509
69intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator (GO:0042771)3.01671528
70nucleoside transmembrane transport (GO:1901642)3.00730147
71regulation of B cell receptor signaling pathway (GO:0050855)3.00619172
72negative regulation of bone resorption (GO:0045779)2.98165476
73neutrophil activation (GO:0042119)2.97708110
74regulation of gamma-delta T cell differentiation (GO:0045586)2.96521421
75DNA damage response, detection of DNA damage (GO:0042769)2.94304363
76pseudouridine synthesis (GO:0001522)2.94078775
77neutrophil activation involved in immune response (GO:0002283)2.93212842
78regulation of alpha-beta T cell proliferation (GO:0046640)2.91671808
79negative regulation of interleukin-12 production (GO:0032695)2.90460252
80quinone metabolic process (GO:1901661)2.89439597
81primitive streak formation (GO:0090009)2.88718845
82negative regulation of interleukin-2 production (GO:0032703)2.88310964
83response to muramyl dipeptide (GO:0032495)2.88305469
84regulation of interleukin-2 biosynthetic process (GO:0045076)2.87226945
85regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.85433359
86regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.84029413
87positive regulation of developmental pigmentation (GO:0048087)2.83870404
88DNA replication-dependent nucleosome organization (GO:0034723)2.83711914
89DNA replication-dependent nucleosome assembly (GO:0006335)2.83711914
90pore complex assembly (GO:0046931)2.83688630
91histone H4-K16 acetylation (GO:0043984)2.83313141
92DNA methylation involved in gamete generation (GO:0043046)2.82671231
93negative regulation of alpha-beta T cell activation (GO:0046636)2.82377133
94histone H3-K4 trimethylation (GO:0080182)2.80490652
95positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.80276845
96positive regulation of alpha-beta T cell proliferation (GO:0046641)2.79597703
97L-fucose catabolic process (GO:0042355)2.79225964
98fucose catabolic process (GO:0019317)2.79225964
99L-fucose metabolic process (GO:0042354)2.79225964
100negative regulation of cell killing (GO:0031342)2.78703424
101negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.78703424
102regulation of translation in response to stress (GO:0043555)2.78161352
103chromatin assembly (GO:0031497)2.77983167
104regulation of germinal center formation (GO:0002634)2.77568337
105positive regulation of interleukin-17 production (GO:0032740)2.75543243
106sister chromatid segregation (GO:0000819)2.75351562
107positive regulation of odontogenesis (GO:0042482)2.75091209
108dendritic cell chemotaxis (GO:0002407)2.72658996
109negative regulation of interleukin-1 production (GO:0032692)2.72138958
110cellular extravasation (GO:0045123)2.71692136
111defense response to protozoan (GO:0042832)2.71362258
112bone trabecula formation (GO:0060346)2.69410327
113mast cell activation (GO:0045576)2.68514020
114negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.68136512
115regulation of T-helper 1 type immune response (GO:0002825)2.67688381
116positive regulation of T-helper cell differentiation (GO:0045624)2.67354202
117neutrophil mediated immunity (GO:0002446)2.66228409
118cullin deneddylation (GO:0010388)2.66135428
119dendritic cell migration (GO:0036336)2.65633182
120positive regulation of tissue remodeling (GO:0034105)2.64383109
121response to protozoan (GO:0001562)2.62896555
122cellular response to interleukin-15 (GO:0071350)2.60437534
123granulocyte activation (GO:0036230)2.59757693
124regulation of interferon-beta biosynthetic process (GO:0045357)2.59614969
125T-helper cell differentiation (GO:0042093)2.58586809
126CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.58586809
127ribosome biogenesis (GO:0042254)2.57935921
128T cell differentiation involved in immune response (GO:0002292)2.56196544
129alpha-beta T cell differentiation involved in immune response (GO:0002293)2.56196544
130alpha-beta T cell activation involved in immune response (GO:0002287)2.56196544
131pyrimidine ribonucleoside catabolic process (GO:0046133)2.55415929
132regulation of defense response to virus by host (GO:0050691)2.54694418
133positive regulation of interferon-beta production (GO:0032728)2.54630293
134negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.54405856
135positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.53844151
136regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.53660844
137regulation of MHC class II biosynthetic process (GO:0045346)2.52886527
138branching involved in labyrinthine layer morphogenesis (GO:0060670)2.52628122
139positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.52582069
140negative regulation of signal transduction by p53 class mediator (GO:1901797)2.52238023
141positive regulation of protein deacetylation (GO:0090312)2.51687413
142nuclear pore organization (GO:0006999)2.51449625
143male meiosis (GO:0007140)2.50533206
144nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.49589957
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.49148904
146regulation of gene silencing by RNA (GO:0060966)2.49128810
147regulation of posttranscriptional gene silencing (GO:0060147)2.49128810
148regulation of gene silencing by miRNA (GO:0060964)2.49128810
149negative thymic T cell selection (GO:0045060)2.48955075
150histone H3-K4 methylation (GO:0051568)2.48056605
151protein deneddylation (GO:0000338)2.48011280
152protein polyglutamylation (GO:0018095)2.47962496
153immunoglobulin mediated immune response (GO:0016064)2.47652591
154mitotic G2/M transition checkpoint (GO:0044818)2.47613609
155regulation of alpha-beta T cell activation (GO:0046634)2.46292560
156negative T cell selection (GO:0043383)2.45352502
157platelet dense granule organization (GO:0060155)2.44837958
158positive regulation of granulocyte differentiation (GO:0030854)2.44499375
159negative regulation of bone remodeling (GO:0046851)2.44437497
160microtubule severing (GO:0051013)2.44411060
161positive regulation of T cell differentiation in thymus (GO:0033089)2.42543147
162leukocyte aggregation (GO:0070486)2.42469231
163regulation of alpha-beta T cell differentiation (GO:0046637)2.41644912
164mast cell activation involved in immune response (GO:0002279)2.41373974
165mast cell degranulation (GO:0043303)2.41373974
166response to interleukin-15 (GO:0070672)2.41310148
167regulation of telomerase activity (GO:0051972)2.40725061
168positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.39883081
169negative regulation of viral release from host cell (GO:1902187)2.38997954
170leukocyte degranulation (GO:0043299)2.38601851
171positive regulation of interleukin-1 beta secretion (GO:0050718)2.38469601
172natural killer cell activation involved in immune response (GO:0002323)2.38243000
173Rap protein signal transduction (GO:0032486)2.37798810
174ventricular system development (GO:0021591)2.37598754
175sperm motility (GO:0030317)2.36459944
176maintenance of protein localization in organelle (GO:0072595)2.35322035
177heterochromatin organization (GO:0070828)2.35187747
178establishment of endothelial barrier (GO:0061028)2.34366879
179negative regulation of T cell differentiation (GO:0045581)2.34141882
180histone mRNA catabolic process (GO:0071044)2.34038192
181regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.34002944
182B cell mediated immunity (GO:0019724)2.33835143
183T cell migration (GO:0072678)2.33594306
184regulation of DNA-dependent DNA replication (GO:0090329)2.33390060
185regulation of T cell receptor signaling pathway (GO:0050856)2.32971798
186regulation of interferon-beta production (GO:0032648)2.32390193
187positive regulation of interleukin-1 secretion (GO:0050716)2.31649480
188regulation of female gonad development (GO:2000194)2.31646116
189negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.28753231
190regulation of translation, ncRNA-mediated (GO:0045974)2.28753231

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human7.59229259
2KLF5_18264089_ChIP-ChIP_MESCs_Mouse6.39438372
3KLF4_18264089_ChIP-ChIP_MESCs_Mouse6.39438372
4KLF2_18264089_ChIP-ChIP_MESCs_Mouse6.39438372
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.90512889
6E2F7_22180533_ChIP-Seq_HELA_Human4.66828936
7TP63_19390658_ChIP-ChIP_HaCaT_Human4.58218014
8IRF8_22096565_ChIP-ChIP_GC-B_Human3.68607933
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.86637962
10NOTCH1_21737748_ChIP-Seq_TLL_Human2.73933753
11ZNF274_21170338_ChIP-Seq_K562_Hela2.71285143
12NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.69831808
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.69421126
14IRF1_19129219_ChIP-ChIP_H3396_Human2.54892262
15SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.46271585
16SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.44194226
17TCF3_18692474_ChIP-Seq_MESCs_Mouse2.26455927
18NANOG_18358816_ChIP-ChIP_MESCs_Mouse2.04998652
19TCF3_18692474_ChIP-Seq_MEFs_Mouse1.98003601
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.94342448
21GATA3_26560356_Chip-Seq_TH2_Human1.88061775
22KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.87979933
23SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.84220763
24RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.83753682
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.81870991
26POU5F1_16153702_ChIP-ChIP_HESCs_Human1.79833272
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.78719711
28RUNX_20019798_ChIP-Seq_JUKART_Human1.76799890
29NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.76006678
30ETS1_20019798_ChIP-Seq_JURKAT_Human1.75570562
31SCL_19346495_ChIP-Seq_HPC-7_Human1.73690430
32IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.72335060
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.71563902
34IRF8_27001747_Chip-Seq_BMDM_Mouse1.69219842
35SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.62363393
36IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.62062801
37EST1_17652178_ChIP-ChIP_JURKAT_Human1.56013317
38BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.52174391
39NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.51196302
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.49646278
41IRF8_21731497_ChIP-ChIP_J774_Mouse1.49264766
42GATA3_27048872_Chip-Seq_THYMUS_Human1.47897667
43EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.46228670
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.45995738
45POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.45484605
46CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.45293974
47VDR_24787735_ChIP-Seq_THP-1_Human1.45158707
48CREB1_15753290_ChIP-ChIP_HEK293T_Human1.43369902
49WT1_19549856_ChIP-ChIP_CCG9911_Human1.41565056
50FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.40907024
51PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.40635766
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.36560832
53VDR_22108803_ChIP-Seq_LS180_Human1.36198526
54TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.34582798
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32804834
56EGR1_19374776_ChIP-ChIP_THP-1_Human1.32108486
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.31566408
58GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31063756
59RNF2_27304074_Chip-Seq_NSC_Mouse1.30481700
60FOXM1_23109430_ChIP-Seq_U2OS_Human1.25497505
61MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.23974233
62E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23966999
63PADI4_21655091_ChIP-ChIP_MCF-7_Human1.23518643
64ER_23166858_ChIP-Seq_MCF-7_Human1.22636121
65SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.20721701
66CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.20698533
67SMRT_27268052_Chip-Seq_Bcells_Human1.19667320
68MYC_19030024_ChIP-ChIP_MESCs_Mouse1.18502824
69ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.17465727
70NANOG_20526341_ChIP-Seq_ESCs_Human1.16721623
71* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.15993829
72GABP_17652178_ChIP-ChIP_JURKAT_Human1.15211716
73IGF1R_20145208_ChIP-Seq_DFB_Human1.15062766
74POU5F1_16518401_ChIP-PET_MESCs_Mouse1.14954868
75FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.14898519
76FOXP3_21729870_ChIP-Seq_TREG_Human1.14280739
77* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14235353
78ELK1_19687146_ChIP-ChIP_HELA_Human1.13804464
79TP53_22573176_ChIP-Seq_HFKS_Human1.12896914
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.12802565
81GATA3_21878914_ChIP-Seq_MCF-7_Human1.11590478
82SRF_21415370_ChIP-Seq_HL-1_Mouse1.11223220
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.11169459
84NANOG_18692474_ChIP-Seq_MESCs_Mouse1.11056823
85GATA3_26560356_Chip-Seq_TH1_Human1.10913267
86PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09702377
87SPI1_23547873_ChIP-Seq_NB4_Human1.09199237
88POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.09161803
89MYC_19079543_ChIP-ChIP_MESCs_Mouse1.08628466
90PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.08198247
91STAT6_21828071_ChIP-Seq_BEAS2B_Human1.07516662
92CIITA_25753668_ChIP-Seq_RAJI_Human1.06934632
93KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.06608623
94EGR1_23403033_ChIP-Seq_LIVER_Mouse1.06352554
95NANOG_18692474_ChIP-Seq_MEFs_Mouse1.06329521
96VDR_24763502_ChIP-Seq_THP-1_Human1.06276933
97STAT1_20625510_ChIP-Seq_HELA_Human1.05439441
98MYC_18940864_ChIP-ChIP_HL60_Human1.05419947
99FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.05313275
100RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.05159885
101CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.03419696
102* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02561970
103MYB_21317192_ChIP-Seq_ERMYB_Mouse1.02302972
104SALL4_22934838_ChIP-ChIP_CD34+_Human1.02146578
105FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01449564
106FOXA1_25329375_ChIP-Seq_VCAP_Human1.01449564
107SOX2_18555785_ChIP-Seq_MESCs_Mouse1.01390787
108* VDR_23849224_ChIP-Seq_CD4+_Human1.01222835
109TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.01038415
110KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.00828521
111EWS_26573619_Chip-Seq_HEK293_Human1.00240566
112NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.99840539
113VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.99686750
114SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.98896121
115SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.98639127
116SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.98349003
117MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.98332594
118EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98120654
119POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.96961087
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96931882
121GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.96686793
122E2F1_17053090_ChIP-ChIP_MCF-7_Human0.96272357
123MYB_26560356_Chip-Seq_TH1_Human0.96142026
124GABP_19822575_ChIP-Seq_HepG2_Human0.95437494
125* NCOR_22424771_ChIP-Seq_293T_Human0.95021467
126ELK1_22589737_ChIP-Seq_MCF10A_Human0.94925215
127MYC_18555785_ChIP-Seq_MESCs_Mouse0.94331408
128STAT3_18555785_ChIP-Seq_MESCs_Mouse0.94269912
129PRDM14_20953172_ChIP-Seq_ESCs_Human0.93995037
130HIF1A_21447827_ChIP-Seq_MCF-7_Human0.93617552
131UTX_26944678_Chip-Seq_JUKART_Human0.92813462
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.92608436
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.92535843
134TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92535843
135PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.92239175
136MYC_18358816_ChIP-ChIP_MESCs_Mouse0.89369334
137SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.88622901
138FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.86130110
139MYB_26560356_Chip-Seq_TH2_Human0.85485451
140SOX2_16153702_ChIP-ChIP_HESCs_Human0.85322221
141ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85183386
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.85073576
143ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.84557602
144JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.82638269
145SOX2_18692474_ChIP-Seq_MESCs_Mouse0.81998378
146KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81824952
147STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.80806110
148RUNX1_22412390_ChIP-Seq_EML_Mouse0.79792591
149STAT3_1855785_ChIP-Seq_MESCs_Mouse0.79768668
150MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.77873896
151HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.77229981
152POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.77189390
153STAT4_19710469_ChIP-ChIP_TH1__Mouse0.77048684
154* TTF2_22483619_ChIP-Seq_HELA_Human0.76072237
155ELF1_17652178_ChIP-ChIP_JURKAT_Human0.75260970
156BMI1_23680149_ChIP-Seq_NPCS_Mouse0.73958852
157OCT4_18692474_ChIP-Seq_MEFs_Mouse0.71534240
158FLI1_27457419_Chip-Seq_LIVER_Mouse0.70738622
159MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.70308429
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.70012198

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006292_abnormal_olfactory_placode4.54667212
2MP0008057_abnormal_DNA_replication4.16573840
3MP0005075_abnormal_melanosome_morpholog4.13784915
4MP0003724_increased_susceptibility_to4.13632299
5MP0003011_delayed_dark_adaptation3.09466742
6MP0004264_abnormal_extraembryonic_tissu3.08204661
7MP0002277_abnormal_respiratory_mucosa2.96764517
8MP0008877_abnormal_DNA_methylation2.53139685
9MP0003122_maternal_imprinting2.51828762
10MP0004381_abnormal_hair_follicle2.46579888
11MP0003890_abnormal_embryonic-extraembry2.43404403
12MP0003183_abnormal_peptide_metabolism2.39867410
13MP0005394_taste/olfaction_phenotype2.35142137
14MP0005499_abnormal_olfactory_system2.35142137
15MP0002254_reproductive_system_inflammat2.34821276
16MP0003136_yellow_coat_color2.32382420
17MP0003121_genomic_imprinting2.26300442
18MP0004957_abnormal_blastocyst_morpholog2.21664139
19MP0002419_abnormal_innate_immunity2.15851625
20MP0006082_CNS_inflammation2.09187433
21MP0008995_early_reproductive_senescence2.05509768
22MP0003195_calcinosis2.03233647
23MP0005410_abnormal_fertilization1.96681807
24MP0002138_abnormal_hepatobiliary_system1.90877811
25MP0005084_abnormal_gallbladder_morpholo1.89120257
26MP0002332_abnormal_exercise_endurance1.85560483
27MP0004858_abnormal_nervous_system1.83124539
28MP0003718_maternal_effect1.82589580
29MP0003787_abnormal_imprinting1.82145598
30MP0001853_heart_inflammation1.81209634
31MP0003938_abnormal_ear_development1.77766979
32MP0005671_abnormal_response_to1.72107539
33MP0009764_decreased_sensitivity_to1.68552631
34MP0000569_abnormal_digit_pigmentation1.61404313
35MP0002396_abnormal_hematopoietic_system1.55342532
36MP0005000_abnormal_immune_tolerance1.53227915
37MP0005257_abnormal_intraocular_pressure1.52070218
38MP0008961_abnormal_basal_metabolism1.52008532
39MP0001845_abnormal_inflammatory_respons1.44179138
40MP0003303_peritoneal_inflammation1.44048971
41MP0003077_abnormal_cell_cycle1.37815394
42MP0003866_abnormal_defecation1.35322345
43MP0001800_abnormal_humoral_immune1.33233660
44MP0001501_abnormal_sleep_pattern1.28756427
45MP0000049_abnormal_middle_ear1.28405642
46MP0009785_altered_susceptibility_to1.26043457
47MP0005387_immune_system_phenotype1.25941665
48MP0001790_abnormal_immune_system1.25941665
49MP0005310_abnormal_salivary_gland1.25802063
50MP0000490_abnormal_crypts_of1.25030702
51MP0001835_abnormal_antigen_presentation1.23830363
52MP0003763_abnormal_thymus_physiology1.23798216
53MP0001293_anophthalmia1.23734756
54MP0001533_abnormal_skeleton_physiology1.22827521
55MP0010094_abnormal_chromosome_stability1.22139643
56MP0000762_abnormal_tongue_morphology1.21781228
57MP0008875_abnormal_xenobiotic_pharmacok1.21460144
58MP0001672_abnormal_embryogenesis/_devel1.20623861
59MP0005380_embryogenesis_phenotype1.20623861
60MP0006072_abnormal_retinal_apoptosis1.20447674
61MP0002751_abnormal_autonomic_nervous1.20361709
62MP0002928_abnormal_bile_duct1.20171871
63MP0008469_abnormal_protein_level1.20134458
64MP0000372_irregular_coat_pigmentation1.19950962
65MP0008789_abnormal_olfactory_epithelium1.18597916
66MP0008932_abnormal_embryonic_tissue1.18269203
67MP0002653_abnormal_ependyma_morphology1.18164250
68MP0008007_abnormal_cellular_replicative1.18010669
69MP0002098_abnormal_vibrissa_morphology1.17172075
70MP0002405_respiratory_system_inflammati1.16847118
71MP0003646_muscle_fatigue1.14891901
72MP0002723_abnormal_immune_serum1.14085479
73MP0001986_abnormal_taste_sensitivity1.13683786
74MP0001929_abnormal_gametogenesis1.13181728
75MP0003806_abnormal_nucleotide_metabolis1.13003741
76MP0000350_abnormal_cell_proliferation1.12245206
77MP0003111_abnormal_nucleus_morphology1.11615471
78MP0003786_premature_aging1.11205063
79MP0006035_abnormal_mitochondrial_morpho1.11087201
80MP0003315_abnormal_perineum_morphology1.10293926
81MP0002163_abnormal_gland_morphology1.09692011
82MP0003252_abnormal_bile_duct1.07049986
83MP0002088_abnormal_embryonic_growth/wei1.06996116
84MP0001819_abnormal_immune_cell1.06549302
85MP0003984_embryonic_growth_retardation1.05829038
86MP0004947_skin_inflammation1.05026816
87MP0002420_abnormal_adaptive_immunity1.05006686
88MP0002398_abnormal_bone_marrow1.04275228
89MP0000689_abnormal_spleen_morphology1.04152523
90MP0003755_abnormal_palate_morphology1.03900090
91MP0002452_abnormal_antigen_presenting1.03854807
92MP0003436_decreased_susceptibility_to1.03418713
93MP0001873_stomach_inflammation1.03142432
94MP0002722_abnormal_immune_system1.01830102
95MP0002127_abnormal_cardiovascular_syste1.01661367
96MP0000432_abnormal_head_morphology1.01170117
97MP0008058_abnormal_DNA_repair1.00857045
98MP0010155_abnormal_intestine_physiology1.00359882
99MP0005025_abnormal_response_to1.00179660
100MP0002092_abnormal_eye_morphology0.99791951
101MP0000678_abnormal_parathyroid_gland0.99066165
102MP0000716_abnormal_immune_system0.98776648
103MP0003656_abnormal_erythrocyte_physiolo0.98161192
104MP0000703_abnormal_thymus_morphology0.97106072
105MP0002132_abnormal_respiratory_system0.96786927
106MP0002148_abnormal_hypersensitivity_rea0.96428325
107MP0009278_abnormal_bone_marrow0.93951465
108MP0002102_abnormal_ear_morphology0.91632068
109MP0001764_abnormal_homeostasis0.91262674
110MP0005646_abnormal_pituitary_gland0.90829301
111MP0002932_abnormal_joint_morphology0.90544083
112MP0003943_abnormal_hepatobiliary_system0.89730531
113MP0002429_abnormal_blood_cell0.89096984
114MP0001545_abnormal_hematopoietic_system0.88988333
115MP0005397_hematopoietic_system_phenotyp0.88988333
116MP0000685_abnormal_immune_system0.88024181
117MP0009333_abnormal_splenocyte_physiolog0.87491008
118MP0003693_abnormal_embryo_hatching0.87242193
119MP0002114_abnormal_axial_skeleton0.86399721
120MP0000015_abnormal_ear_pigmentation0.86175595
121MP0005464_abnormal_platelet_physiology0.84076511
122MP0003448_altered_tumor_morphology0.83771421
123MP0005379_endocrine/exocrine_gland_phen0.83195174
124MP0004133_heterotaxia0.82612147
125MP0000313_abnormal_cell_death0.81597638
126MP0002006_tumorigenesis0.80900348
127MP0002233_abnormal_nose_morphology0.80670917
128MP0005551_abnormal_eye_electrophysiolog0.80591660
129MP0003698_abnormal_male_reproductive0.80493712
130MP0005391_vision/eye_phenotype0.80179948
131MP0002166_altered_tumor_susceptibility0.80154430
132MP0002085_abnormal_embryonic_tissue0.80014793
133MP0001849_ear_inflammation0.78632233
134MP0003937_abnormal_limbs/digits/tail_de0.77096896
135MP0002210_abnormal_sex_determination0.76997627
136MP0004883_abnormal_blood_vessel0.76405430
137MP0002116_abnormal_craniofacial_bone0.76217723
138MP0001188_hyperpigmentation0.75410637
139MP0002095_abnormal_skin_pigmentation0.74316588
140MP0008872_abnormal_physiological_respon0.73864670
141MP0001919_abnormal_reproductive_system0.73493824
142MP0005164_abnormal_response_to0.71750691
143MP0010352_gastrointestinal_tract_polyps0.71146777
144MP0006036_abnormal_mitochondrial_physio0.70714532
145MP0003828_pulmonary_edema0.70448750
146MP0002876_abnormal_thyroid_physiology0.70376937
147MP0002086_abnormal_extraembryonic_tissu0.70250931
148MP0000653_abnormal_sex_gland0.70065904
149MP0001348_abnormal_lacrimal_gland0.69722020
150MP0005395_other_phenotype0.68977401
151MP0009765_abnormal_xenobiotic_induced0.68818950
152MP0009763_increased_sensitivity_to0.68059989
153MP0010030_abnormal_orbit_morphology0.67707115
154MP0005174_abnormal_tail_pigmentation0.66096868
155MP0004197_abnormal_fetal_growth/weight/0.64564713
156MP0002019_abnormal_tumor_incidence0.64378833
157MP0005248_abnormal_Harderian_gland0.63339909
158MP0001286_abnormal_eye_development0.62692914

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)5.42795019
2Hypochromic microcytic anemia (HP:0004840)4.82864607
3Rib fusion (HP:0000902)4.48315700
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.31790367
5Rectovaginal fistula (HP:0000143)3.84147046
6Rectal fistula (HP:0100590)3.84147046
7Chromsome breakage (HP:0040012)3.83285711
8Stomach cancer (HP:0012126)3.63020615
9Nephroblastoma (Wilms tumor) (HP:0002667)3.62192747
10Hypoplasia of the fovea (HP:0007750)3.62084324
11Aplasia/Hypoplasia of the fovea (HP:0008060)3.62084324
12Intestinal fistula (HP:0100819)3.44448029
13Embryonal renal neoplasm (HP:0011794)3.41098034
14Anomalous pulmonary venous return (HP:0010772)3.28469214
15Fused cervical vertebrae (HP:0002949)3.20554226
16Testicular atrophy (HP:0000029)3.17697528
17Vaginal fistula (HP:0004320)3.13976493
18Ependymoma (HP:0002888)3.11252997
19Abnormal delayed hypersensitivity skin test (HP:0002963)3.09426495
20Hepatoblastoma (HP:0002884)3.06522236
21Eczematoid dermatitis (HP:0000976)3.04908485
22Pancreatic cysts (HP:0001737)3.04472876
23Molar tooth sign on MRI (HP:0002419)3.04068393
24Abnormality of midbrain morphology (HP:0002418)3.04068393
25Abnormality of the pulmonary veins (HP:0011718)2.99449400
26Abnormality of T cell physiology (HP:0011840)2.96891170
27Abnormal rod and cone electroretinograms (HP:0008323)2.95943307
28Absent rod-and cone-mediated responses on ERG (HP:0007688)2.94714605
29Recurrent bacterial skin infections (HP:0005406)2.90158075
30Partial duplication of thumb phalanx (HP:0009944)2.85969718
31Recurrent fungal infections (HP:0002841)2.83715673
32Nasolacrimal duct obstruction (HP:0000579)2.83455653
33Recurrent abscess formation (HP:0002722)2.82042768
34IgG deficiency (HP:0004315)2.77813283
35Abnormality of glycolipid metabolism (HP:0010969)2.76804921
36Abnormality of liposaccharide metabolism (HP:0010968)2.76804921
37Abnormality of glycosphingolipid metabolism (HP:0004343)2.76804921
38Neoplasm of striated muscle (HP:0009728)2.76361703
39Abnormality of the fovea (HP:0000493)2.74992662
40Sensory axonal neuropathy (HP:0003390)2.68432615
41Pancreatic fibrosis (HP:0100732)2.68342168
42Rhabdomyosarcoma (HP:0002859)2.66643969
43Severe visual impairment (HP:0001141)2.64905071
44Meckel diverticulum (HP:0002245)2.64384569
45Abnormality of T cells (HP:0002843)2.63589703
46Abnormality of the ileum (HP:0001549)2.61955840
47Orchitis (HP:0100796)2.58871947
48Chronic sinusitis (HP:0011109)2.56432392
49Panhypogammaglobulinemia (HP:0003139)2.55661287
50Autoimmune thrombocytopenia (HP:0001973)2.47354261
51Abnormal lung lobation (HP:0002101)2.46462982
52Multiple enchondromatosis (HP:0005701)2.46255385
53Bifid tongue (HP:0010297)2.46165967
54Combined immunodeficiency (HP:0005387)2.46048962
55Nephronophthisis (HP:0000090)2.44648390
56Prostate neoplasm (HP:0100787)2.44212281
57Mediastinal lymphadenopathy (HP:0100721)2.43508323
58Partial duplication of the phalanx of hand (HP:0009999)2.42567470
59Aplasia/hypoplasia of the humerus (HP:0006507)2.42362606
603-Methylglutaconic aciduria (HP:0003535)2.42342570
61Oligodactyly (hands) (HP:0001180)2.41955945
62Supernumerary spleens (HP:0009799)2.41931335
63Azoospermia (HP:0000027)2.40945273
64Abnormal spermatogenesis (HP:0008669)2.40224412
65True hermaphroditism (HP:0010459)2.35591750
66Aplasia/Hypoplasia of the uvula (HP:0010293)2.33161200
67Recurrent bronchitis (HP:0002837)2.32176012
68Reduced antithrombin III activity (HP:0001976)2.31867391
69Keratoconjunctivitis (HP:0001096)2.31501917
70Encephalitis (HP:0002383)2.31476162
71IgM deficiency (HP:0002850)2.31133312
72Abnormality of macrophages (HP:0004311)2.29115943
73Abnormality of B cell number (HP:0010975)2.28851388
74Abnormality of the lower motor neuron (HP:0002366)2.28536474
75Meningitis (HP:0001287)2.27603750
76Elevated erythrocyte sedimentation rate (HP:0003565)2.27243047
77Impulsivity (HP:0100710)2.27101527
78Keratoconjunctivitis sicca (HP:0001097)2.26855125
79Abnormality of the salivary glands (HP:0010286)2.26594753
80Supernumerary ribs (HP:0005815)2.25896914
81Horizontal nystagmus (HP:0000666)2.24970498
82Myositis (HP:0100614)2.24955273
83Volvulus (HP:0002580)2.24830826
84Amyotrophic lateral sclerosis (HP:0007354)2.23832187
85Mitochondrial inheritance (HP:0001427)2.23318433
86Vasculitis (HP:0002633)2.20869555
87Duplication of thumb phalanx (HP:0009942)2.20238635
88Attenuation of retinal blood vessels (HP:0007843)2.19442888
89Short humerus (HP:0005792)2.19253055
90Acute necrotizing encephalopathy (HP:0006965)2.18971941
91Supernumerary bones of the axial skeleton (HP:0009144)2.16668176
92Aplasia/Hypoplasia of the macula (HP:0008059)2.16366092
93Chronic mucocutaneous candidiasis (HP:0002728)2.15467982
94Recurrent cutaneous fungal infections (HP:0011370)2.15467982
95Alveolar cell carcinoma (HP:0006519)2.14837348
96Abnormality of T cell number (HP:0011839)2.14034695
97Upper limb muscle weakness (HP:0003484)2.13816830
98Abnormality of renal resorption (HP:0011038)2.13098276
99Leukocytosis (HP:0001974)2.11858865
100Autoimmune hemolytic anemia (HP:0001890)2.10521514
101Microvesicular hepatic steatosis (HP:0001414)2.09091303
102Abnormality of the renal medulla (HP:0100957)2.08116506
103B lymphocytopenia (HP:0010976)2.07779429
104Cheilitis (HP:0100825)2.07146942
105Hypochromic anemia (HP:0001931)2.06886403
106Neutropenia (HP:0001875)2.05865333
107Abnormal respiratory motile cilium physiology (HP:0012261)2.05483258
108Preauricular pit (HP:0004467)2.05349492
109Periauricular skin pits (HP:0100277)2.05349492
110Chronic obstructive pulmonary disease (HP:0006510)2.05236717
111Obstructive lung disease (HP:0006536)2.05236717
112Absent/shortened dynein arms (HP:0200106)2.04632541
113Dynein arm defect of respiratory motile cilia (HP:0012255)2.04632541
114Severe combined immunodeficiency (HP:0004430)2.03722462
115Abnormality of the lacrimal duct (HP:0011481)2.03099802
116Recurrent skin infections (HP:0001581)2.00869972
117Increased IgE level (HP:0003212)2.00267083
118Parakeratosis (HP:0001036)2.00076927
119Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.99160539
120Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.98259916
121Increased CSF lactate (HP:0002490)1.98159623
122Trismus (HP:0000211)1.96780078
123Pulmonary infiltrates (HP:0002113)1.96553733
124Lipid accumulation in hepatocytes (HP:0006561)1.96536624
125Abnormality of the preputium (HP:0100587)1.96405589
126Eosinophilia (HP:0001880)1.96207903
127Astrocytoma (HP:0009592)1.95626492
128Abnormality of the astrocytes (HP:0100707)1.95626492
129Hypothermia (HP:0002045)1.95371315
130Pustule (HP:0200039)1.95103951
131Dyschromatopsia (HP:0007641)1.94922326
132Large earlobe (HP:0009748)1.94267047
133Abnormality of the pleura (HP:0002103)1.93218567
134Congenital stationary night blindness (HP:0007642)1.93195406
135Progressive macrocephaly (HP:0004481)1.92488369
136Abnormality of the phalanges of the hallux (HP:0010057)1.92441489
137Methylmalonic acidemia (HP:0002912)1.92194583
138Neoplasm of the tracheobronchial system (HP:0100552)1.91589473
139Granulocytopenia (HP:0001913)1.91552684
140T lymphocytopenia (HP:0005403)1.89744900
141Tongue fasciculations (HP:0001308)1.88821410
142Abnormality of eosinophils (HP:0001879)1.88728502
143Medial flaring of the eyebrow (HP:0010747)1.88339618
144Vertebral fusion (HP:0002948)1.87674520
145Aplasia/Hypoplasia affecting the retina (HP:0008061)1.87578022
146Abnormal ciliary motility (HP:0012262)1.87481147
147Pendular nystagmus (HP:0012043)1.86184303
148Increased IgM level (HP:0003496)1.84532513
149Hemoptysis (HP:0002105)1.84384375
150Abnormality of the renal cortex (HP:0011035)1.84152368
151Shawl scrotum (HP:0000049)1.83545341
152Increased hepatocellular lipid droplets (HP:0006565)1.83270963
153Type I transferrin isoform profile (HP:0003642)1.83034042
154Abnormal mitochondria in muscle tissue (HP:0008316)1.82852788
155Bile duct proliferation (HP:0001408)1.82223632
156Abnormal biliary tract physiology (HP:0012439)1.82223632
157Acute encephalopathy (HP:0006846)1.81995015
158Abnormality of dental color (HP:0011073)1.81527206
159Exertional dyspnea (HP:0002875)1.80421293
160Abnormal respiratory motile cilium morphology (HP:0005938)1.79931254
161Abnormal respiratory epithelium morphology (HP:0012253)1.79931254
162Abnormality of chromosome segregation (HP:0002916)1.79646171
163Bronchitis (HP:0012387)1.79562430
164Abnormality of macular pigmentation (HP:0008002)1.78795488
165Stomatitis (HP:0010280)1.78029000
166Hyperventilation (HP:0002883)1.77602389
167Absent radius (HP:0003974)1.76830104
168Gangrene (HP:0100758)1.76461079
169Renal Fanconi syndrome (HP:0001994)1.75727362
170Abnormality of the nasolacrimal system (HP:0000614)1.75331683
171Small intestinal stenosis (HP:0012848)1.73785999
172Duodenal stenosis (HP:0100867)1.73785999
173Aplastic anemia (HP:0001915)1.73079801
174Aplasia/Hypoplasia of the spleen (HP:0010451)1.72391558
175Abnormality of chromosome stability (HP:0003220)1.72209087
176Preauricular skin tag (HP:0000384)1.71302301
177Bone marrow hypocellularity (HP:0005528)1.69541800
178Retrobulbar optic neuritis (HP:0100654)1.68852786
179Optic neuritis (HP:0100653)1.68852786
180Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68549558
181Absent forearm bone (HP:0003953)1.68280081
182Aplasia involving forearm bones (HP:0009822)1.68280081
183Triphalangeal thumb (HP:0001199)1.66957076
184Abnormality of small intestinal villus morphology (HP:0011472)1.66265564
185Villous atrophy (HP:0011473)1.66265564
186Asplenia (HP:0001746)1.65627850
187Abnormality of the prostate (HP:0008775)1.63997339

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.96805403
2GRK53.96212152
3GRK63.68230182
4ADRBK23.30632775
5GRK13.05156640
6ERN12.77838115
7NUAK12.61430885
8MATK2.56486136
9CSF1R2.54620288
10GRK72.33293082
11STK102.22284896
12MAP4K22.02927974
13PLK41.99336012
14SRPK11.93336093
15MAPK71.82784562
16TGFBR21.81019587
17TYRO31.72756088
18STK241.72751823
19MAP3K141.72660887
20CDK71.69177145
21TTK1.62115036
22FRK1.55934592
23IKBKB1.54150554
24TXK1.47829540
25MST41.46871698
26TLK11.44480386
27BLK1.40678898
28AKT31.39618604
29WNK11.38638431
30BRD41.28524686
31ITK1.26036669
32MOS1.25634880
33SIK31.22699370
34EIF2AK21.21774883
35IRAK31.21573196
36VRK21.17676065
37CHUK1.17541615
38YES11.17349560
39TYK21.15867164
40CSK1.14480276
41SYK1.14098547
42EIF2AK31.13819501
43ZAK1.13722958
44MARK21.13478726
45HIPK21.12743056
46INSRR1.11726954
47ACVR1B1.10410203
48IRAK41.09039416
49STK161.06955574
50CHEK21.06629217
51ZAP701.01403353
52KIT0.99152716
53PIK3CG0.96960915
54MAPK130.96037165
55VRK10.92279869
56DYRK20.91896676
57SIK20.90939827
58BMPR1B0.89015392
59ADRBK10.88214641
60TESK20.88095813
61BUB10.87440105
62CAMK40.83019663
63FGFR30.82981487
64PLK10.81904482
65PBK0.79312292
66PIM10.79199038
67PRKG20.78755142
68FES0.77380143
69EPHB10.74594531
70MAP2K30.74269083
71MKNK20.71608720
72WNK30.70712395
73TNIK0.68206636
74EPHA20.67934529
75IRAK10.65013327
76TEC0.64706861
77STK40.64327476
78NME10.64213388
79CDK80.63629839
80NLK0.62519556
81LCK0.60355174
82EPHA30.60288824
83TAOK30.60018460
84MAPKAPK30.59523955
85DYRK30.59220665
86PLK20.58748064
87IRAK20.58481332
88JAK20.56172562
89PIM20.55559353
90* CHEK10.55128692
91CASK0.54494316
92CDC70.53721565
93PAK30.53058200
94JAK10.52690285
95MAP4K10.52247308
96NTRK10.51931450
97MKNK10.51357414
98MAP3K120.50573933
99PRKCI0.50085677
100PTK2B0.49338870
101PKN10.48516394
102PASK0.47835053
103BMPR20.47718785
104HCK0.47226530
105MAP3K30.46778666
106STK30.46149045
107CLK10.46125157
108CDK40.45615446
109GSK3A0.45499693
110MAP2K60.42076902
111PDK10.41666512
112OXSR10.41439214
113ALK0.41422548
114MAP2K20.41061314
115LYN0.40308638
116MAP3K130.39350527
117RIPK40.39218998
118IGF1R0.38302993
119PRKCD0.37802064
120ABL10.37659463
121MAP3K50.37548890
122INSR0.37089405
123CDK20.36538052
124PRKCQ0.36400493
125MAP3K100.36378717
126DYRK1A0.35980136
127AURKA0.35577889
128MAPK150.35284416
129TBK10.35161705
130PAK40.35043497
131ATM0.34939032
132JAK30.34688785
133ERBB30.34307070
134FER0.32363774
135CDK10.31753577
136IKBKE0.31587068
137MAP3K110.31010347
138BRSK20.30560082
139NEK60.29859793
140MARK30.29758630
141TNK20.28916191
142AKT20.27921701
143BTK0.27909421
144MAPK100.27802592
145MAPKAPK20.26904062
146FGR0.26564715
147TRPM70.24755150
148PLK30.23711566

Predicted pathways (KEGG)

RankGene SetZ-score
1Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.48614997
2Vitamin B6 metabolism_Homo sapiens_hsa007503.37777837
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.97470627
4Proteasome_Homo sapiens_hsa030502.45824279
5Graft-versus-host disease_Homo sapiens_hsa053322.20647991
6Arachidonic acid metabolism_Homo sapiens_hsa005902.03467336
7Oxidative phosphorylation_Homo sapiens_hsa001902.02895410
8NF-kappa B signaling pathway_Homo sapiens_hsa040641.96585609
9Fanconi anemia pathway_Homo sapiens_hsa034601.91867377
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.87483203
11Homologous recombination_Homo sapiens_hsa034401.78160604
12RNA polymerase_Homo sapiens_hsa030201.75267112
13Primary immunodeficiency_Homo sapiens_hsa053401.74975586
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.71515505
15RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64046985
16Parkinsons disease_Homo sapiens_hsa050121.59829997
17Spliceosome_Homo sapiens_hsa030401.56798068
18Linoleic acid metabolism_Homo sapiens_hsa005911.50939361
19Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.44262433
20Basal transcription factors_Homo sapiens_hsa030221.43945523
21Hematopoietic cell lineage_Homo sapiens_hsa046401.40560023
22Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.37548348
23Mismatch repair_Homo sapiens_hsa034301.36655258
24Non-homologous end-joining_Homo sapiens_hsa034501.36125393
25Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.31512390
26Transcriptional misregulation in cancer_Homo sapiens_hsa052021.28654139
27alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28212782
28Ether lipid metabolism_Homo sapiens_hsa005651.27585468
29Herpes simplex infection_Homo sapiens_hsa051681.27301546
30mRNA surveillance pathway_Homo sapiens_hsa030151.26639914
31Measles_Homo sapiens_hsa051621.23549955
32Staphylococcus aureus infection_Homo sapiens_hsa051501.23347625
33Allograft rejection_Homo sapiens_hsa053301.22725918
34T cell receptor signaling pathway_Homo sapiens_hsa046601.22117615
35Caffeine metabolism_Homo sapiens_hsa002321.21984447
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.21112592
37Huntingtons disease_Homo sapiens_hsa050161.18161765
38DNA replication_Homo sapiens_hsa030301.17570521
39Fructose and mannose metabolism_Homo sapiens_hsa000511.17122710
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.16676436
41RNA transport_Homo sapiens_hsa030131.15054446
42Ribosome_Homo sapiens_hsa030101.14244353
43RNA degradation_Homo sapiens_hsa030181.14089272
44Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.12986675
45Other glycan degradation_Homo sapiens_hsa005111.11384876
46Circadian rhythm_Homo sapiens_hsa047101.05563827
47Collecting duct acid secretion_Homo sapiens_hsa049661.03176895
48Dorso-ventral axis formation_Homo sapiens_hsa043201.02315980
49Autoimmune thyroid disease_Homo sapiens_hsa053201.02255494
50Jak-STAT signaling pathway_Homo sapiens_hsa046301.00742137
51Olfactory transduction_Homo sapiens_hsa047400.99878834
52SNARE interactions in vesicular transport_Homo sapiens_hsa041300.97567996
53p53 signaling pathway_Homo sapiens_hsa041150.97406873
54Cell cycle_Homo sapiens_hsa041100.97315943
55Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.96479265
56B cell receptor signaling pathway_Homo sapiens_hsa046620.95689885
57Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.94864221
58Leishmaniasis_Homo sapiens_hsa051400.94767017
59Phototransduction_Homo sapiens_hsa047440.92532142
60African trypanosomiasis_Homo sapiens_hsa051430.89577631
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.87806401
62Acute myeloid leukemia_Homo sapiens_hsa052210.87366238
63Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86611029
64Antigen processing and presentation_Homo sapiens_hsa046120.85136449
65Base excision repair_Homo sapiens_hsa034100.84419679
66Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.83122985
67Malaria_Homo sapiens_hsa051440.79868645
68MicroRNAs in cancer_Homo sapiens_hsa052060.78305596
69Osteoclast differentiation_Homo sapiens_hsa043800.77801217
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.77139212
71Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.76786658
72Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.74467212
73NOD-like receptor signaling pathway_Homo sapiens_hsa046210.74441819
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73394704
75Rheumatoid arthritis_Homo sapiens_hsa053230.73391143
76Apoptosis_Homo sapiens_hsa042100.73271056
77Legionellosis_Homo sapiens_hsa051340.72759466
78Pathways in cancer_Homo sapiens_hsa052000.72321049
79Regulation of autophagy_Homo sapiens_hsa041400.72242416
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70082721
81Alzheimers disease_Homo sapiens_hsa050100.68286984
82Influenza A_Homo sapiens_hsa051640.67296857
83Pyrimidine metabolism_Homo sapiens_hsa002400.66981199
84Inositol phosphate metabolism_Homo sapiens_hsa005620.66904805
85Sphingolipid metabolism_Homo sapiens_hsa006000.65600612
86TNF signaling pathway_Homo sapiens_hsa046680.64907307
87Selenocompound metabolism_Homo sapiens_hsa004500.64759240
88Phospholipase D signaling pathway_Homo sapiens_hsa040720.63197527
89Epstein-Barr virus infection_Homo sapiens_hsa051690.63057350
90Choline metabolism in cancer_Homo sapiens_hsa052310.61586374
91Asthma_Homo sapiens_hsa053100.61312373
92Thyroid cancer_Homo sapiens_hsa052160.60605854
93Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59749166
94Nucleotide excision repair_Homo sapiens_hsa034200.59728902
95Serotonergic synapse_Homo sapiens_hsa047260.59210482
96Pertussis_Homo sapiens_hsa051330.58168033
97Galactose metabolism_Homo sapiens_hsa000520.57345058
98Purine metabolism_Homo sapiens_hsa002300.56398883
99Shigellosis_Homo sapiens_hsa051310.56058224
100Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.55697274
101Folate biosynthesis_Homo sapiens_hsa007900.55446625
102Chemokine signaling pathway_Homo sapiens_hsa040620.54891892
103Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54737038
104Viral carcinogenesis_Homo sapiens_hsa052030.53708787
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53396609
106Nitrogen metabolism_Homo sapiens_hsa009100.52718564
107HTLV-I infection_Homo sapiens_hsa051660.51677980
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.51642623
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51346580
110Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50607731
111Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.49342135
112Chemical carcinogenesis_Homo sapiens_hsa052040.49012665
113Ovarian steroidogenesis_Homo sapiens_hsa049130.48889324
114Protein export_Homo sapiens_hsa030600.48449465
115Ras signaling pathway_Homo sapiens_hsa040140.48236519
116Toxoplasmosis_Homo sapiens_hsa051450.47444029
117Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.46609312
118Hepatitis C_Homo sapiens_hsa051600.45133510
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.45099280
120Notch signaling pathway_Homo sapiens_hsa043300.44423199
121Tuberculosis_Homo sapiens_hsa051520.42831125
122Type I diabetes mellitus_Homo sapiens_hsa049400.42819719
123Glycosaminoglycan degradation_Homo sapiens_hsa005310.42571709
124Pancreatic cancer_Homo sapiens_hsa052120.42220203
125Hepatitis B_Homo sapiens_hsa051610.40790909
126Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.40176364
127Phagosome_Homo sapiens_hsa041450.39716279
128Prostate cancer_Homo sapiens_hsa052150.39397957
129Viral myocarditis_Homo sapiens_hsa054160.30786283
130Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.27443472
131Salmonella infection_Homo sapiens_hsa051320.26586899
132Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.25308578

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