CWC27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.52219864
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.49330685
3DNA strand elongation (GO:0022616)4.33672520
4ribosomal small subunit assembly (GO:0000028)4.33273310
5telomere maintenance via semi-conservative replication (GO:0032201)4.32103781
6formation of translation preinitiation complex (GO:0001731)4.24387775
7DNA replication initiation (GO:0006270)4.18791814
8histone exchange (GO:0043486)4.18739964
9nucleobase biosynthetic process (GO:0046112)4.16328305
10maturation of SSU-rRNA (GO:0030490)4.14620629
11chaperone-mediated protein transport (GO:0072321)4.09549867
12ribosomal large subunit biogenesis (GO:0042273)4.03966484
13establishment of protein localization to mitochondrial membrane (GO:0090151)3.96367309
14ribosomal small subunit biogenesis (GO:0042274)3.96198004
15DNA double-strand break processing (GO:0000729)3.94497223
16DNA unwinding involved in DNA replication (GO:0006268)3.94336007
17telomere maintenance via recombination (GO:0000722)3.91217286
18ATP synthesis coupled proton transport (GO:0015986)3.89324678
19energy coupled proton transport, down electrochemical gradient (GO:0015985)3.89324678
20nucleotide-excision repair, DNA gap filling (GO:0006297)3.83893699
21somatic hypermutation of immunoglobulin genes (GO:0016446)3.80361948
22somatic diversification of immune receptors via somatic mutation (GO:0002566)3.80361948
23telomere maintenance via telomere lengthening (GO:0010833)3.79500459
24establishment of integrated proviral latency (GO:0075713)3.74367361
25mitotic recombination (GO:0006312)3.73480028
26mitotic metaphase plate congression (GO:0007080)3.69681775
27ribonucleoprotein complex biogenesis (GO:0022613)3.66701635
28CENP-A containing nucleosome assembly (GO:0034080)3.63757996
29ribosome assembly (GO:0042255)3.63711948
30mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.62533996
31purine nucleobase biosynthetic process (GO:0009113)3.61414125
32viral transcription (GO:0019083)3.61411566
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.60791928
34protein neddylation (GO:0045116)3.58619706
357-methylguanosine mRNA capping (GO:0006370)3.55966242
36DNA replication checkpoint (GO:0000076)3.55462404
37translational termination (GO:0006415)3.55033505
38chromatin remodeling at centromere (GO:0031055)3.54182213
39protein localization to kinetochore (GO:0034501)3.52219469
407-methylguanosine RNA capping (GO:0009452)3.51953225
41RNA capping (GO:0036260)3.51953225
42replication fork processing (GO:0031297)3.51704183
43viral mRNA export from host cell nucleus (GO:0046784)3.49858707
44spliceosomal complex assembly (GO:0000245)3.49684617
45cullin deneddylation (GO:0010388)3.46672944
46anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.46654132
47transcription-coupled nucleotide-excision repair (GO:0006283)3.46535407
48proteasome assembly (GO:0043248)3.45317842
49ribosome biogenesis (GO:0042254)3.44496880
50transcription elongation from RNA polymerase III promoter (GO:0006385)3.44006963
51termination of RNA polymerase III transcription (GO:0006386)3.44006963
52positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.43754353
53regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.41440581
54negative regulation of DNA-dependent DNA replication (GO:2000104)3.39807065
55rRNA processing (GO:0006364)3.39534831
56regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.39412738
57regulation of mitotic spindle checkpoint (GO:1903504)3.39412738
58metaphase plate congression (GO:0051310)3.38676287
59kinetochore organization (GO:0051383)3.37741996
60protein complex biogenesis (GO:0070271)3.35900433
61DNA damage response, detection of DNA damage (GO:0042769)3.35522609
62spliceosomal snRNP assembly (GO:0000387)3.34820967
63translational initiation (GO:0006413)3.33333068
64DNA ligation (GO:0006266)3.31021371
65mitochondrial respiratory chain complex assembly (GO:0033108)3.29983233
66mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.28670681
67mitochondrial respiratory chain complex I assembly (GO:0032981)3.28670681
68NADH dehydrogenase complex assembly (GO:0010257)3.28670681
69negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.28590444
70negative regulation of ligase activity (GO:0051352)3.28590444
71somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)3.28262430
72somatic diversification of immunoglobulins involved in immune response (GO:0002208)3.28262430
73isotype switching (GO:0045190)3.28262430
74transcription elongation from RNA polymerase I promoter (GO:0006362)3.26743378
75SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.26528338
76IMP biosynthetic process (GO:0006188)3.26404219
77translational elongation (GO:0006414)3.25284374
78rRNA metabolic process (GO:0016072)3.25141091
79DNA replication-independent nucleosome organization (GO:0034724)3.24089908
80DNA replication-independent nucleosome assembly (GO:0006336)3.24089908
81regulation of nuclear cell cycle DNA replication (GO:0033262)3.23834011
82cotranslational protein targeting to membrane (GO:0006613)3.22966754
83DNA deamination (GO:0045006)3.22849794
84protein deneddylation (GO:0000338)3.21242158
85DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.19682458
86deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.18802564
87maturation of 5.8S rRNA (GO:0000460)3.18757160
88histone H2A acetylation (GO:0043968)3.18687458
89protein targeting to ER (GO:0045047)3.18418509
90intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.17111867
91signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.17111867
92signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.15893477
93signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.15893477
94signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.15893477
95respiratory electron transport chain (GO:0022904)3.14315306
96pseudouridine synthesis (GO:0001522)3.13678489
97cellular component biogenesis (GO:0044085)3.13069849
98signal transduction involved in DNA damage checkpoint (GO:0072422)3.12327575
99signal transduction involved in DNA integrity checkpoint (GO:0072401)3.12327575
100signal transduction involved in cell cycle checkpoint (GO:0072395)3.09689528
101kinetochore assembly (GO:0051382)3.09185656
102establishment of chromosome localization (GO:0051303)3.08973153
103protein K6-linked ubiquitination (GO:0085020)3.08371035
104electron transport chain (GO:0022900)3.08093313
105translation (GO:0006412)3.07478403
106termination of RNA polymerase I transcription (GO:0006363)3.07446174
107mitotic nuclear envelope disassembly (GO:0007077)3.07098431
108regulation of centriole replication (GO:0046599)3.03977419
109attachment of spindle microtubules to kinetochore (GO:0008608)3.02716702
110cell cycle G1/S phase transition (GO:0044843)3.02534271
111G1/S transition of mitotic cell cycle (GO:0000082)3.02534271
112establishment of protein localization to endoplasmic reticulum (GO:0072599)3.02174913
113histone mRNA metabolic process (GO:0008334)3.02068511
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.01916263
115rRNA modification (GO:0000154)3.01904919
116IMP metabolic process (GO:0046040)2.99255431
117regulation of telomere maintenance via telomerase (GO:0032210)2.99221271
118nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.99220742
119protein localization to endoplasmic reticulum (GO:0070972)2.98820562
120DNA replication-dependent nucleosome assembly (GO:0006335)2.98792413
121DNA replication-dependent nucleosome organization (GO:0034723)2.98792413
122positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.98476621
123establishment of viral latency (GO:0019043)2.97221420
124nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.97063742
125DNA catabolic process, exonucleolytic (GO:0000738)2.96122072
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.96081637
127respiratory chain complex IV assembly (GO:0008535)2.93066806
128centriole replication (GO:0007099)2.88417691
129maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85912483
130double-strand break repair via nonhomologous end joining (GO:0006303)2.83407944
131non-recombinational repair (GO:0000726)2.83407944
132resolution of meiotic recombination intermediates (GO:0000712)2.83250272
133regulation of mitochondrial translation (GO:0070129)2.79100196
134regulation of DNA endoreduplication (GO:0032875)2.77617577
135recombinational repair (GO:0000725)2.75434499
136regulation of helicase activity (GO:0051095)2.74255195
137water-soluble vitamin biosynthetic process (GO:0042364)2.73862034
138spindle checkpoint (GO:0031577)2.71606974
139mitotic G2/M transition checkpoint (GO:0044818)2.71463866
140double-strand break repair via homologous recombination (GO:0000724)2.70940872
141rRNA methylation (GO:0031167)2.68973162
142inner mitochondrial membrane organization (GO:0007007)2.68081039
143telomere maintenance via telomerase (GO:0007004)2.67537991
144peptidyl-histidine modification (GO:0018202)2.62867772
145negative regulation of DNA recombination (GO:0045910)2.62526685
146negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.61964498
147negative regulation of mitotic sister chromatid segregation (GO:0033048)2.61964498
148negative regulation of mitotic sister chromatid separation (GO:2000816)2.61964498
149negative regulation of sister chromatid segregation (GO:0033046)2.61964498
150negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.61964498
151cytochrome complex assembly (GO:0017004)2.61896496
152RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.59278696
153tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.59278696
154mitotic spindle checkpoint (GO:0071174)2.58804523
155intraciliary transport (GO:0042073)2.57048066
156mitotic sister chromatid cohesion (GO:0007064)2.56449158
157organelle disassembly (GO:1903008)2.56047469
158postreplication repair (GO:0006301)2.55653427
159ATP-dependent chromatin remodeling (GO:0043044)2.55587791

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.77619347
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.44355521
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.07538292
4EST1_17652178_ChIP-ChIP_JURKAT_Human3.84984760
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.73492733
6GABP_17652178_ChIP-ChIP_JURKAT_Human3.54109934
7JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.32025580
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.29771971
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.29250845
10FOXM1_23109430_ChIP-Seq_U2OS_Human3.26220337
11CREB1_15753290_ChIP-ChIP_HEK293T_Human3.19503137
12CHD1_19587682_ChIP-ChIP_MESCs_Mouse3.03229094
13MYC_19030024_ChIP-ChIP_MESCs_Mouse2.98496645
14HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.97514922
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.93159574
16MYC_18358816_ChIP-ChIP_MESCs_Mouse2.90913230
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.85103485
18NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.80789805
19* VDR_23849224_ChIP-Seq_CD4+_Human2.60524709
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.55834062
21HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.53155218
22NELFA_20434984_ChIP-Seq_ESCs_Mouse2.51700300
23XRN2_22483619_ChIP-Seq_HELA_Human2.30212345
24* FOXP3_21729870_ChIP-Seq_TREG_Human2.28844986
25ELK1_19687146_ChIP-ChIP_HELA_Human2.25584128
26THAP11_20581084_ChIP-Seq_MESCs_Mouse2.22401891
27E2F1_18555785_ChIP-Seq_MESCs_Mouse2.21451554
28VDR_22108803_ChIP-Seq_LS180_Human2.20527220
29ZNF274_21170338_ChIP-Seq_K562_Hela2.17278775
30SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.11407000
31* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10095071
32MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09564575
33DCP1A_22483619_ChIP-Seq_HELA_Human2.09094881
34YY1_21170310_ChIP-Seq_MESCs_Mouse2.06503906
35PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.03129324
36* TTF2_22483619_ChIP-Seq_HELA_Human2.01659123
37SRF_21415370_ChIP-Seq_HL-1_Mouse2.01356439
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.00898446
39MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.00673551
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.00529197
41AR_21909140_ChIP-Seq_LNCAP_Human1.91298541
42GABP_19822575_ChIP-Seq_HepG2_Human1.89893745
43E2F1_21310950_ChIP-Seq_MCF-7_Human1.89289439
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.89245639
45POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87649746
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.85067942
47POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.82125772
48HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80792558
49NANOG_18555785_ChIP-Seq_MESCs_Mouse1.78944317
50PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.77235064
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.75944768
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.73503064
53SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.72861381
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.70323797
55FLI1_27457419_Chip-Seq_LIVER_Mouse1.68360543
56CIITA_25753668_ChIP-Seq_RAJI_Human1.67588421
57P300_19829295_ChIP-Seq_ESCs_Human1.64057385
58IGF1R_20145208_ChIP-Seq_DFB_Human1.62560746
59POU5F1_16153702_ChIP-ChIP_HESCs_Human1.61111066
60* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.60663474
61GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57116888
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.56934099
63TAF15_26573619_Chip-Seq_HEK293_Human1.55029285
64GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.46511016
65EGR1_19374776_ChIP-ChIP_THP-1_Human1.45500684
66PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45312053
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.41378639
68POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.39741292
69TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39218927
70SALL1_21062744_ChIP-ChIP_HESCs_Human1.36152773
71CTBP2_25329375_ChIP-Seq_LNCAP_Human1.35170178
72ZFX_18555785_ChIP-Seq_MESCs_Mouse1.33842717
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.32140227
74GBX2_23144817_ChIP-Seq_PC3_Human1.30673382
75CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.29827209
76SOX2_16153702_ChIP-ChIP_HESCs_Human1.26483752
77KDM5A_27292631_Chip-Seq_BREAST_Human1.25372118
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.24193670
79* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.23910693
80ERG_20887958_ChIP-Seq_HPC-7_Mouse1.23287963
81PCGF2_27294783_Chip-Seq_ESCs_Mouse1.22312798
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.19826336
83ELK1_22589737_ChIP-Seq_MCF10A_Human1.17385846
84SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16707128
85MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16542889
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15632296
87SOX2_18555785_ChIP-Seq_MESCs_Mouse1.15161572
88TFEB_21752829_ChIP-Seq_HELA_Human1.10607219
89POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.10478847
90TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.10367666
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.09638586
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08999970
93BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.08672519
94MYC_18940864_ChIP-ChIP_HL60_Human1.08308855
95RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.08264480
96GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.04810523
97DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.02067739
98FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.01645045
99EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.00155183
100ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.97592604
101CBP_20019798_ChIP-Seq_JUKART_Human0.97295620
102IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.97295620
103UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96601759
104* SMAD3_21741376_ChIP-Seq_EPCs_Human0.96294549
105EZH2_27294783_Chip-Seq_NPCs_Mouse0.95245424
106SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.94338792
107NOTCH1_21737748_ChIP-Seq_TLL_Human0.94139437
108CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.93733547
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.93292309
110SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.92587390
111* TP53_22573176_ChIP-Seq_HFKS_Human0.92496272
112NANOG_19829295_ChIP-Seq_ESCs_Human0.91167294
113SOX2_19829295_ChIP-Seq_ESCs_Human0.91167294
114TOP2B_26459242_ChIP-Seq_MCF-7_Human0.90495645
115SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90333579
116TCF3_18692474_ChIP-Seq_MEFs_Mouse0.89741366
117KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89489951
118ER_23166858_ChIP-Seq_MCF-7_Human0.89454897
119EWS_26573619_Chip-Seq_HEK293_Human0.89427573
120KLF5_20875108_ChIP-Seq_MESCs_Mouse0.88853963
121SPI1_23547873_ChIP-Seq_NB4_Human0.88823908
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.87462809
123SUZ12_27294783_Chip-Seq_NPCs_Mouse0.87244960
124NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86012457
125GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85691671
126SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.85479785
127* SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.85366423
128NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.85186004
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85112602
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.84437665
131FUS_26573619_Chip-Seq_HEK293_Human0.82138466
132NANOG_16153702_ChIP-ChIP_HESCs_Human0.78853580
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77963186
134IRF1_19129219_ChIP-ChIP_H3396_Human0.76963042
135CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.76941087
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.76929224
137CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.76572797
138NANOG_21062744_ChIP-ChIP_HESCs_Human0.74057731
139OCT4_18692474_ChIP-Seq_MEFs_Mouse0.72390439
140NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.71655454

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.88090299
2MP0010094_abnormal_chromosome_stability4.61393799
3MP0004957_abnormal_blastocyst_morpholog4.24837074
4MP0003111_abnormal_nucleus_morphology4.07198614
5MP0008058_abnormal_DNA_repair3.99733613
6MP0003077_abnormal_cell_cycle3.93785754
7MP0008057_abnormal_DNA_replication3.81766956
8MP0008932_abnormal_embryonic_tissue3.04738051
9MP0008007_abnormal_cellular_replicative2.84752717
10MP0002102_abnormal_ear_morphology2.48278969
11MP0006292_abnormal_olfactory_placode2.35385356
12MP0003123_paternal_imprinting2.24308058
13MP0008877_abnormal_DNA_methylation2.21015635
14MP0002396_abnormal_hematopoietic_system2.17412376
15MP0003786_premature_aging2.07296877
16MP0001730_embryonic_growth_arrest2.03348678
17MP0000350_abnormal_cell_proliferation1.91733179
18MP0002736_abnormal_nociception_after1.86547494
19MP0003787_abnormal_imprinting1.75078454
20MP0003718_maternal_effect1.63198779
21MP0003880_abnormal_central_pattern1.62876226
22MP0003121_genomic_imprinting1.62732343
23MP0003806_abnormal_nucleotide_metabolis1.59007604
24MP0001984_abnormal_olfaction1.57258488
25MP0008995_early_reproductive_senescence1.56252020
26MP0003890_abnormal_embryonic-extraembry1.55248216
27MP0004133_heterotaxia1.54984128
28MP0008789_abnormal_olfactory_epithelium1.54311007
29MP0001697_abnormal_embryo_size1.51148263
30MP0001529_abnormal_vocalization1.50217101
31MP0003122_maternal_imprinting1.50156743
32MP0005380_embryogenesis_phenotype1.49412890
33MP0001672_abnormal_embryogenesis/_devel1.49412890
34MP0003950_abnormal_plasma_membrane1.41183410
35MP0001485_abnormal_pinna_reflex1.41070254
36MP0010352_gastrointestinal_tract_polyps1.40523315
37MP0003567_abnormal_fetal_cardiomyocyte1.37768982
38MP0002837_dystrophic_cardiac_calcinosis1.36148282
39MP0003984_embryonic_growth_retardation1.36146896
40MP0002080_prenatal_lethality1.35920225
41MP0009379_abnormal_foot_pigmentation1.34714776
42MP0010030_abnormal_orbit_morphology1.32837596
43MP0002088_abnormal_embryonic_growth/wei1.32093412
44MP0002085_abnormal_embryonic_tissue1.30599783
45MP0000313_abnormal_cell_death1.30182315
46MP0002233_abnormal_nose_morphology1.29520472
47MP0001293_anophthalmia1.26839501
48MP0001188_hyperpigmentation1.24850994
49MP0002234_abnormal_pharynx_morphology1.24642687
50MP0002084_abnormal_developmental_patter1.21976816
51MP0005253_abnormal_eye_physiology1.21802000
52MP0000647_abnormal_sebaceous_gland1.20760303
53MP0001968_abnormal_touch/_nociception1.20518826
54MP0002210_abnormal_sex_determination1.17990067
55MP0005084_abnormal_gallbladder_morpholo1.16701842
56MP0000631_abnormal_neuroendocrine_gland1.15581628
57MP0005394_taste/olfaction_phenotype1.11474781
58MP0005499_abnormal_olfactory_system1.11474781
59MP0003315_abnormal_perineum_morphology1.11224068
60MP0006035_abnormal_mitochondrial_morpho1.10422784
61MP0004215_abnormal_myocardial_fiber1.08508295
62MP0002163_abnormal_gland_morphology1.08004568
63MP0000778_abnormal_nervous_system1.07391953
64MP0005551_abnormal_eye_electrophysiolog1.06944141
65MP0002019_abnormal_tumor_incidence1.05984081
66MP0009697_abnormal_copulation1.05971149
67MP0003195_calcinosis1.05586212
68MP0004197_abnormal_fetal_growth/weight/1.03993581
69MP0002086_abnormal_extraembryonic_tissu1.02545095
70MP0001145_abnormal_male_reproductive1.02335971
71MP0003221_abnormal_cardiomyocyte_apopto1.00459548
72MP0002938_white_spotting0.99702056
73MP0004147_increased_porphyrin_level0.99074960
74MP0003755_abnormal_palate_morphology0.97610348
75MP0002095_abnormal_skin_pigmentation0.97402111
76MP0002697_abnormal_eye_size0.96907880
77MP0000537_abnormal_urethra_morphology0.95376873
78MP0003828_pulmonary_edema0.95000502
79MP0002254_reproductive_system_inflammat0.94939245
80MP0001286_abnormal_eye_development0.92739630
81MP0005187_abnormal_penis_morphology0.92613975
82MP0000358_abnormal_cell_content/0.91132312
83MP0001986_abnormal_taste_sensitivity0.90187340
84MP0000427_abnormal_hair_cycle0.90091176
85MP0003283_abnormal_digestive_organ0.89965435
86MP0000490_abnormal_crypts_of0.89389300
87MP0006276_abnormal_autonomic_nervous0.89287850
88MP0008872_abnormal_physiological_respon0.88995523
89MP0001853_heart_inflammation0.88132693
90MP0005391_vision/eye_phenotype0.88010437
91MP0003861_abnormal_nervous_system0.87393341
92MP0008260_abnormal_autophagy0.87197967
93MP0002184_abnormal_innervation0.87147477
94MP0000653_abnormal_sex_gland0.86626657
95MP0009333_abnormal_splenocyte_physiolog0.86605012
96MP0004142_abnormal_muscle_tone0.86549148
97MP0009046_muscle_twitch0.86114988
98MP0000049_abnormal_middle_ear0.85825705
99MP0003385_abnormal_body_wall0.84188551
100MP0006036_abnormal_mitochondrial_physio0.82758867
101MP0002653_abnormal_ependyma_morphology0.82205519
102MP0002090_abnormal_vision0.81099586
103MP0003698_abnormal_male_reproductive0.80832774
104MP0005384_cellular_phenotype0.80156010
105MP0002160_abnormal_reproductive_system0.79355682
106MP0002752_abnormal_somatic_nervous0.79272594
107MP0000372_irregular_coat_pigmentation0.78893695
108MP0002282_abnormal_trachea_morphology0.78859123
109MP0003937_abnormal_limbs/digits/tail_de0.78448878
110MP0010307_abnormal_tumor_latency0.78365200
111MP0001486_abnormal_startle_reflex0.77362044
112MP0001929_abnormal_gametogenesis0.77075092
113MP0002272_abnormal_nervous_system0.77033383
114MP0000703_abnormal_thymus_morphology0.76769506
115MP0002398_abnormal_bone_marrow0.74464672
116MP0005389_reproductive_system_phenotype0.72787292
117MP0002722_abnormal_immune_system0.72611937
118MP0004808_abnormal_hematopoietic_stem0.72293396
119MP0006072_abnormal_retinal_apoptosis0.71837592
120MP0003136_yellow_coat_color0.70490378
121MP0003941_abnormal_skin_development0.69734326
122MP0005367_renal/urinary_system_phenotyp0.69714805
123MP0000516_abnormal_urinary_system0.69714805
124MP0000750_abnormal_muscle_regeneration0.69106551
125MP0002638_abnormal_pupillary_reflex0.68676423
126MP0002751_abnormal_autonomic_nervous0.68430556
127MP0005266_abnormal_metabolism0.67996107
128MP0000015_abnormal_ear_pigmentation0.67580083
129MP0000689_abnormal_spleen_morphology0.67468671
130MP0005621_abnormal_cell_physiology0.65159337
131MP0002127_abnormal_cardiovascular_syste0.65012172
132MP0002111_abnormal_tail_morphology0.64722090
133MP0005408_hypopigmentation0.64539200
134MP0003119_abnormal_digestive_system0.64447688
135MP0004084_abnormal_cardiac_muscle0.62548910
136MP0003763_abnormal_thymus_physiology0.60811898
137MP0002429_abnormal_blood_cell0.59351006
138MP0003186_abnormal_redox_activity0.59268540
139MP0001119_abnormal_female_reproductive0.59043530
140MP0004233_abnormal_muscle_weight0.58882410
141MP0002114_abnormal_axial_skeleton0.57665086
142MP0001835_abnormal_antigen_presentation0.56935326

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.35310109
2Reticulocytopenia (HP:0001896)3.93350781
3Colon cancer (HP:0003003)3.74278181
4Cerebral hypomyelination (HP:0006808)3.60563171
5Agnosia (HP:0010524)3.56656069
6Chromsome breakage (HP:0040012)3.25555808
7Aplastic anemia (HP:0001915)3.24567478
8Medulloblastoma (HP:0002885)3.18936221
9Acute necrotizing encephalopathy (HP:0006965)3.07203835
10Increased serum pyruvate (HP:0003542)3.03713873
11Abnormality of glycolysis (HP:0004366)3.03713873
12Abnormality of cells of the erythroid lineage (HP:0012130)3.00741710
13Chromosomal breakage induced by crosslinking agents (HP:0003221)2.99259915
14Abnormality of the labia minora (HP:0012880)2.92924969
15Rough bone trabeculation (HP:0100670)2.89870353
16Abnormality of chromosome stability (HP:0003220)2.86381827
17Cerebral edema (HP:0002181)2.82405924
18Meckel diverticulum (HP:0002245)2.82337620
19Supernumerary spleens (HP:0009799)2.79178439
20Oral leukoplakia (HP:0002745)2.78397571
21Ependymoma (HP:0002888)2.78329161
22Premature graying of hair (HP:0002216)2.76802232
23Abnormality of the ileum (HP:0001549)2.76562333
24Breast hypoplasia (HP:0003187)2.75951696
25Abnormal mitochondria in muscle tissue (HP:0008316)2.73165509
26Increased CSF lactate (HP:0002490)2.65008598
27Pallor (HP:0000980)2.63349526
28Abnormality of the preputium (HP:0100587)2.61661971
29Mitochondrial inheritance (HP:0001427)2.61281743
30Macrocytic anemia (HP:0001972)2.61054406
31Absent radius (HP:0003974)2.60378064
32Abnormal number of erythroid precursors (HP:0012131)2.59567201
33Bone marrow hypocellularity (HP:0005528)2.57935241
34Patellar aplasia (HP:0006443)2.57220984
35Carpal bone hypoplasia (HP:0001498)2.53175761
363-Methylglutaconic aciduria (HP:0003535)2.51506089
37Methylmalonic acidemia (HP:0002912)2.50281750
38Intestinal atresia (HP:0011100)2.50216559
39True hermaphroditism (HP:0010459)2.49947793
40Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.49101387
41Decreased activity of mitochondrial respiratory chain (HP:0008972)2.49101387
42Abnormal lung lobation (HP:0002101)2.48998488
43Renal Fanconi syndrome (HP:0001994)2.48065783
44Molar tooth sign on MRI (HP:0002419)2.47153722
45Abnormality of midbrain morphology (HP:0002418)2.47153722
46Type I transferrin isoform profile (HP:0003642)2.45607228
47Absent forearm bone (HP:0003953)2.40704626
48Aplasia involving forearm bones (HP:0009822)2.40704626
49Nephronophthisis (HP:0000090)2.38507957
50Medial flaring of the eyebrow (HP:0010747)2.31955731
51Aplasia/Hypoplasia of the patella (HP:0006498)2.31249460
52Abnormality of the columella (HP:0009929)2.30967944
53Hepatocellular necrosis (HP:0001404)2.29625638
54Aplasia/Hypoplasia of the uvula (HP:0010293)2.29319336
55Progressive macrocephaly (HP:0004481)2.27839918
56Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.27651066
57Cellular immunodeficiency (HP:0005374)2.26564065
58Aplasia/Hypoplasia of the sacrum (HP:0008517)2.26112262
59Hyperglycinemia (HP:0002154)2.25057413
60Optic nerve hypoplasia (HP:0000609)2.24049412
61Volvulus (HP:0002580)2.23569386
62Increased serum lactate (HP:0002151)2.22742359
63Aplasia/Hypoplasia of the sternum (HP:0006714)2.22604629
64Stenosis of the external auditory canal (HP:0000402)2.22328031
65Selective tooth agenesis (HP:0001592)2.22037930
66Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.21980639
67Horseshoe kidney (HP:0000085)2.21023479
68Myelodysplasia (HP:0002863)2.19693101
69Triphalangeal thumb (HP:0001199)2.17026387
70Acute encephalopathy (HP:0006846)2.16461319
71Abnormal trabecular bone morphology (HP:0100671)2.15471918
72Increased hepatocellular lipid droplets (HP:0006565)2.15103591
73Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.14178091
74Neoplasm of the pancreas (HP:0002894)2.13458423
75Hypoplasia of the pons (HP:0012110)2.11885658
76Absent thumb (HP:0009777)2.11776405
77Cleft eyelid (HP:0000625)2.10203049
78Small intestinal stenosis (HP:0012848)2.07361402
79Duodenal stenosis (HP:0100867)2.07361402
80Abnormality of the duodenum (HP:0002246)2.06786725
81Sloping forehead (HP:0000340)2.06022636
82Microvesicular hepatic steatosis (HP:0001414)2.05665481
83Optic disc pallor (HP:0000543)2.04475001
84Hepatic necrosis (HP:0002605)2.04084975
85Abnormality of the pons (HP:0007361)2.03815311
86Oligodactyly (hands) (HP:0001180)2.03788474
87Absent septum pellucidum (HP:0001331)2.03733314
88Abnormal number of incisors (HP:0011064)2.03163752
89Abnormality of the anterior horn cell (HP:0006802)2.02719549
90Degeneration of anterior horn cells (HP:0002398)2.02719549
91Asplenia (HP:0001746)2.01879115
92Anophthalmia (HP:0000528)2.00382267
93Hypoplasia of the radius (HP:0002984)2.00295115
94Abnormality of methionine metabolism (HP:0010901)2.00251486
95Leukodystrophy (HP:0002415)1.99631467
96Exercise intolerance (HP:0003546)1.96868501
97Proximal placement of thumb (HP:0009623)1.96012115
98Lactic acidosis (HP:0003128)1.95611204
99Hypoplasia of the capital femoral epiphysis (HP:0003090)1.95093189
100Methylmalonic aciduria (HP:0012120)1.92322505
101Genital tract atresia (HP:0001827)1.91555032
102Abnormality of the renal medulla (HP:0100957)1.91261858
103Abnormality of abdominal situs (HP:0011620)1.90344446
104Abdominal situs inversus (HP:0003363)1.90344446
105Sclerocornea (HP:0000647)1.89537025
106Pancreatic fibrosis (HP:0100732)1.88864185
107Abnormality of the septum pellucidum (HP:0007375)1.87724824
108Congenital primary aphakia (HP:0007707)1.87479575
109Pancytopenia (HP:0001876)1.87215948
110Rhabdomyosarcoma (HP:0002859)1.86691632
111Respiratory difficulties (HP:0002880)1.86563365
112Impulsivity (HP:0100710)1.85858812
113Vaginal atresia (HP:0000148)1.85851104
114Neoplasm of the colon (HP:0100273)1.85529159
115Pancreatic islet-cell hyperplasia (HP:0004510)1.85185276
116Exertional dyspnea (HP:0002875)1.85041666
117Gait imbalance (HP:0002141)1.84742648
118Bifid tongue (HP:0010297)1.84735769
119Respiratory failure (HP:0002878)1.83952315
120Congenital, generalized hypertrichosis (HP:0004540)1.83481363
121Ectopic kidney (HP:0000086)1.82533835
122Lymphoma (HP:0002665)1.81736300
123IgM deficiency (HP:0002850)1.81580272
124Abnormality of renal resorption (HP:0011038)1.81343256
125CNS hypomyelination (HP:0003429)1.80939550
126Atresia of the external auditory canal (HP:0000413)1.80886668
127Deviation of the thumb (HP:0009603)1.80112853
128Abnormality of serum amino acid levels (HP:0003112)1.79951787
129Secondary amenorrhea (HP:0000869)1.79501751
130IgG deficiency (HP:0004315)1.79408211
131Aplasia/Hypoplasia of the tongue (HP:0010295)1.79296698
132Abnormality of aspartate family amino acid metabolism (HP:0010899)1.79258434
133Pancreatic cysts (HP:0001737)1.79053120
134Anencephaly (HP:0002323)1.78212984
135Optic nerve coloboma (HP:0000588)1.77907878
136Short thumb (HP:0009778)1.77468003
137Lipid accumulation in hepatocytes (HP:0006561)1.76886198
138Microretrognathia (HP:0000308)1.76569501
139Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76383448
140Gastrointestinal atresia (HP:0002589)1.76222012
141Septo-optic dysplasia (HP:0100842)1.75768039
142Nephroblastoma (Wilms tumor) (HP:0002667)1.75597974
143Duplicated collecting system (HP:0000081)1.75085844
144Hypoplastic pelvis (HP:0008839)1.73635574
145Tracheoesophageal fistula (HP:0002575)1.73216520
146Pendular nystagmus (HP:0012043)1.73196975
147Postaxial foot polydactyly (HP:0001830)1.72647473
148Small hand (HP:0200055)1.71948708
149Nephrogenic diabetes insipidus (HP:0009806)1.70406631
150Preaxial hand polydactyly (HP:0001177)1.69931473
151Embryonal renal neoplasm (HP:0011794)1.69354312
152Hyperinsulinemic hypoglycemia (HP:0000825)1.65871673

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.88914831
2STK163.60269278
3WEE13.54042100
4CDC73.46932148
5EIF2AK13.40803617
6TSSK63.03400533
7TNIK2.94059124
8WNK32.71889376
9EIF2AK32.47952322
10CDK82.34722978
11SRPK12.33158060
12TRIM282.33098060
13PLK42.17234963
14TESK22.13080326
15VRK22.10249060
16PLK32.03422704
17VRK11.99879374
18BRSK21.97291807
19NEK11.89866558
20MKNK11.89426682
21TGFBR11.83887147
22PASK1.78022357
23PLK11.71135100
24CCNB11.69606583
25TTK1.66465558
26BMPR1B1.60986928
27MAP4K21.59797571
28ACVR1B1.53769283
29PNCK1.52945434
30CDK71.43776700
31ATR1.43736832
32AURKB1.43328387
33NME21.38001874
34PIM21.35800688
35TAF11.34184302
36ZAK1.33438006
37MKNK21.29578275
38CASK1.28299932
39FRK1.24726114
40RPS6KB21.23038284
41NEK21.19943846
42PBK1.19062404
43AKT31.17716129
44LIMK11.16967625
45CHEK21.16190360
46MAP3K41.14199668
47BRAF1.12980629
48INSRR1.12173422
49CHEK11.11413813
50GRK11.09556519
51AURKA1.00070619
52BCR0.99206155
53EIF2AK20.99059666
54OXSR10.97913514
55MAP3K120.95102118
56EPHA40.92362554
57MAPK130.90242381
58BRSK10.89246223
59ERBB30.88299102
60DYRK30.88069499
61STK390.86984519
62MST40.86501334
63CSNK2A20.84717533
64NUAK10.84538237
65PLK20.83953554
66ATM0.83745999
67PDK20.83347586
68STK38L0.82931929
69CSNK1G10.82660923
70CDK120.82502254
71NME10.82303780
72OBSCN0.81367197
73WNK40.79451892
74BCKDK0.78188165
75CSNK1G20.77769055
76CDK190.77003751
77ERBB40.76388789
78TLK10.75937437
79STK100.75238770
80PRKCG0.75001984
81CSNK2A10.74290621
82STK40.73702063
83MINK10.73373611
84MAP2K70.72642170
85DYRK20.71153049
86CDK20.69447741
87STK30.66788185
88EPHA20.66462248
89YES10.65662346
90ARAF0.65201839
91CDK10.62422902
92PAK10.60801094
93PINK10.60227902
94IRAK40.58217183
95RPS6KA50.57592862
96PAK30.56125841
97CDK40.54527570
98BMPR20.54403622
99TESK10.54271918
100SIK30.54041843
101PDK30.53569952
102PDK40.53569952
103PAK40.52818410
104PRKCE0.51606372
105MARK10.48800638
106MAP3K80.48083365
107TXK0.45425102
108CSNK1A1L0.45337831
109DAPK10.45023746
110PRKCI0.43229660
111MYLK0.42502354
112TEC0.41278051
113NLK0.41096885
114CSNK1E0.39994753
115PIM10.36829397
116BRD40.36388821
117CAMK2A0.33518163
118FLT30.33382529
119RPS6KA40.33329458
120CSNK1G30.33149916
121LRRK20.32648909
122PRKDC0.31773860
123CSNK1A10.30882401
124ILK0.30355369
125ADRBK20.29526648
126RPS6KL10.28572887
127RPS6KC10.28572887
128CDK30.28082936
129TIE10.27337519
130RPS6KB10.27217549
131PRKACB0.26251933
132RPS6KA60.24821050
133PRKG10.24524380
134ALK0.23055901
135MELK0.22466011
136STK240.21535657
137FGFR10.21004688
138KDR0.20214442

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.44623591
2Mismatch repair_Homo sapiens_hsa034304.39890174
3Proteasome_Homo sapiens_hsa030504.18525342
4Ribosome_Homo sapiens_hsa030103.81316035
5RNA polymerase_Homo sapiens_hsa030203.71401712
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.46579841
7Spliceosome_Homo sapiens_hsa030403.27114194
8Nucleotide excision repair_Homo sapiens_hsa034202.92621559
9RNA transport_Homo sapiens_hsa030132.89026402
10Base excision repair_Homo sapiens_hsa034102.85399926
11Homologous recombination_Homo sapiens_hsa034402.84691563
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.72679114
13Pyrimidine metabolism_Homo sapiens_hsa002402.49396527
14Non-homologous end-joining_Homo sapiens_hsa034502.44136479
15Basal transcription factors_Homo sapiens_hsa030222.32731326
16Cell cycle_Homo sapiens_hsa041102.28188109
17Fanconi anemia pathway_Homo sapiens_hsa034602.09528161
18Propanoate metabolism_Homo sapiens_hsa006402.03955732
19RNA degradation_Homo sapiens_hsa030182.00787170
20Protein export_Homo sapiens_hsa030601.95155640
21One carbon pool by folate_Homo sapiens_hsa006701.75788584
22Oxidative phosphorylation_Homo sapiens_hsa001901.69128704
23Steroid biosynthesis_Homo sapiens_hsa001001.67812382
24Parkinsons disease_Homo sapiens_hsa050121.59826193
25Purine metabolism_Homo sapiens_hsa002301.51161939
26mRNA surveillance pathway_Homo sapiens_hsa030151.46565092
27Huntingtons disease_Homo sapiens_hsa050161.39975665
28Pyruvate metabolism_Homo sapiens_hsa006201.37312239
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.36867713
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34505975
31Epstein-Barr virus infection_Homo sapiens_hsa051691.19161163
32Butanoate metabolism_Homo sapiens_hsa006501.16260619
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.16255915
34p53 signaling pathway_Homo sapiens_hsa041151.15680725
35Fatty acid elongation_Homo sapiens_hsa000621.15405801
36Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.13758761
37Phototransduction_Homo sapiens_hsa047441.06346037
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.03270755
39Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.02579506
40Alzheimers disease_Homo sapiens_hsa050100.93867708
41Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87566915
42Maturity onset diabetes of the young_Homo sapiens_hsa049500.82512572
43Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.81891059
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80255972
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79420275
46Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.78720620
47Peroxisome_Homo sapiens_hsa041460.76075810
48Nicotine addiction_Homo sapiens_hsa050330.75584103
49Antigen processing and presentation_Homo sapiens_hsa046120.75317336
50Oocyte meiosis_Homo sapiens_hsa041140.73108866
51Fatty acid metabolism_Homo sapiens_hsa012120.72485705
52Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.69741801
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.64769072
54Regulation of autophagy_Homo sapiens_hsa041400.64331084
55Systemic lupus erythematosus_Homo sapiens_hsa053220.63489591
56Viral carcinogenesis_Homo sapiens_hsa052030.63000554
57Primary immunodeficiency_Homo sapiens_hsa053400.61112852
58Herpes simplex infection_Homo sapiens_hsa051680.57943533
59Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54662748
60Hedgehog signaling pathway_Homo sapiens_hsa043400.54170947
61Tryptophan metabolism_Homo sapiens_hsa003800.54068537
62Fatty acid degradation_Homo sapiens_hsa000710.53939898
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52384249
64Cysteine and methionine metabolism_Homo sapiens_hsa002700.50671543
65Glutathione metabolism_Homo sapiens_hsa004800.50613389
66Olfactory transduction_Homo sapiens_hsa047400.50031505
67Pentose phosphate pathway_Homo sapiens_hsa000300.49139945
68HTLV-I infection_Homo sapiens_hsa051660.47970682
69Cardiac muscle contraction_Homo sapiens_hsa042600.47245713
70Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.46812414
71Biosynthesis of amino acids_Homo sapiens_hsa012300.46070960
72Selenocompound metabolism_Homo sapiens_hsa004500.43555984
73Folate biosynthesis_Homo sapiens_hsa007900.43004715
74beta-Alanine metabolism_Homo sapiens_hsa004100.40237262
75Fructose and mannose metabolism_Homo sapiens_hsa000510.39255393
76Legionellosis_Homo sapiens_hsa051340.38648783
77Caffeine metabolism_Homo sapiens_hsa002320.38530170
78Pentose and glucuronate interconversions_Homo sapiens_hsa000400.38344694
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38262593
80Autoimmune thyroid disease_Homo sapiens_hsa053200.36116362
81Allograft rejection_Homo sapiens_hsa053300.35477731
82Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.35178467
83Nitrogen metabolism_Homo sapiens_hsa009100.33300752
84Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.33165873
85Metabolic pathways_Homo sapiens_hsa011000.32963268
86Colorectal cancer_Homo sapiens_hsa052100.32650320
87Taste transduction_Homo sapiens_hsa047420.31592165
88Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.30669789
89Arginine and proline metabolism_Homo sapiens_hsa003300.28741241
90Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.28722846
91Cyanoamino acid metabolism_Homo sapiens_hsa004600.28683993
92MicroRNAs in cancer_Homo sapiens_hsa052060.28631810
93Chemical carcinogenesis_Homo sapiens_hsa052040.28426101
94Retinol metabolism_Homo sapiens_hsa008300.27596864
95Drug metabolism - other enzymes_Homo sapiens_hsa009830.27546700
96Asthma_Homo sapiens_hsa053100.27224835
97Viral myocarditis_Homo sapiens_hsa054160.27055569
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.26664916
99Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.26193007
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26111622
101Phagosome_Homo sapiens_hsa041450.25781714
102Collecting duct acid secretion_Homo sapiens_hsa049660.25752723
103Vibrio cholerae infection_Homo sapiens_hsa051100.25660931
104Carbon metabolism_Homo sapiens_hsa012000.24929606
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24379203
106Linoleic acid metabolism_Homo sapiens_hsa005910.24088418
107TGF-beta signaling pathway_Homo sapiens_hsa043500.23965880
108Arachidonic acid metabolism_Homo sapiens_hsa005900.23905574
109N-Glycan biosynthesis_Homo sapiens_hsa005100.22512969
110Ether lipid metabolism_Homo sapiens_hsa005650.22301241
111Thyroid cancer_Homo sapiens_hsa052160.22017730
112Intestinal immune network for IgA production_Homo sapiens_hsa046720.21320611
113Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20777539
114Renin-angiotensin system_Homo sapiens_hsa046140.20304357
115Alcoholism_Homo sapiens_hsa050340.20160595
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.19860326
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.19676208
118Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.18842813
119Pathways in cancer_Homo sapiens_hsa052000.16023913
120NOD-like receptor signaling pathway_Homo sapiens_hsa046210.14829436
1212-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.14215932
122NF-kappa B signaling pathway_Homo sapiens_hsa040640.13950170
123Primary bile acid biosynthesis_Homo sapiens_hsa001200.13875322
124Basal cell carcinoma_Homo sapiens_hsa052170.13781238
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.13279189
126Apoptosis_Homo sapiens_hsa042100.13120051
127Serotonergic synapse_Homo sapiens_hsa047260.12969476
128Measles_Homo sapiens_hsa051620.12933721
129Hematopoietic cell lineage_Homo sapiens_hsa046400.12596838
130Shigellosis_Homo sapiens_hsa051310.10759947
131Hippo signaling pathway_Homo sapiens_hsa043900.10224649
132Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.10136793
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.09237456
134Wnt signaling pathway_Homo sapiens_hsa043100.09037633
135HIF-1 signaling pathway_Homo sapiens_hsa040660.08553701
136Galactose metabolism_Homo sapiens_hsa000520.08401110
137Hepatitis B_Homo sapiens_hsa051610.07622926
138Vitamin B6 metabolism_Homo sapiens_hsa007500.06829139
139SNARE interactions in vesicular transport_Homo sapiens_hsa041300.06229961
140PI3K-Akt signaling pathway_Homo sapiens_hsa041510.05590640

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