CWF19L1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the CWF19 protein family. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia-17 and mild mental retardation. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA strand elongation involved in DNA replication (GO:0006271)4.73634860
2nucleobase biosynthetic process (GO:0046112)4.71259004
3DNA unwinding involved in DNA replication (GO:0006268)4.64635868
4purine nucleobase biosynthetic process (GO:0009113)4.64546238
5DNA strand elongation (GO:0022616)4.50732416
6folic acid-containing compound biosynthetic process (GO:0009396)4.23195952
7DNA replication initiation (GO:0006270)4.21973889
8telomere maintenance via semi-conservative replication (GO:0032201)4.20094286
9glycine metabolic process (GO:0006544)4.19892255
10IMP biosynthetic process (GO:0006188)3.96235335
11DNA replication checkpoint (GO:0000076)3.88852162
12nuclear pore organization (GO:0006999)3.87102953
13protein localization to kinetochore (GO:0034501)3.84252981
14folic acid metabolic process (GO:0046655)3.81568504
15formation of translation preinitiation complex (GO:0001731)3.81549712
16tetrahydrofolate metabolic process (GO:0046653)3.81061853
17telomere maintenance via recombination (GO:0000722)3.76272155
18serine family amino acid biosynthetic process (GO:0009070)3.75978965
19nuclear pore complex assembly (GO:0051292)3.75366695
20mitotic recombination (GO:0006312)3.68448651
21mitotic nuclear envelope disassembly (GO:0007077)3.67702349
22DNA replication-dependent nucleosome assembly (GO:0006335)3.63629174
23DNA replication-dependent nucleosome organization (GO:0034723)3.63629174
24negative regulation of DNA-dependent DNA replication (GO:2000104)3.62331143
25L-serine metabolic process (GO:0006563)3.61321291
26regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.59353214
27telomere maintenance via telomere lengthening (GO:0010833)3.52519503
28mitotic metaphase plate congression (GO:0007080)3.49675317
29meiotic chromosome segregation (GO:0045132)3.48777765
30DNA double-strand break processing (GO:0000729)3.45002112
31respiratory chain complex IV assembly (GO:0008535)3.44705223
32IMP metabolic process (GO:0046040)3.39302148
33maturation of SSU-rRNA (GO:0030490)3.39199602
34nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.37926637
35nuclear envelope disassembly (GO:0051081)3.36703153
36membrane disassembly (GO:0030397)3.36703153
37chromatin remodeling at centromere (GO:0031055)3.35017515
38folic acid-containing compound metabolic process (GO:0006760)3.30768297
39replication fork processing (GO:0031297)3.29715248
40protein K6-linked ubiquitination (GO:0085020)3.27384454
41regulation of mitotic spindle checkpoint (GO:1903504)3.26258379
42regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.26258379
43ribosomal small subunit assembly (GO:0000028)3.24722174
44nucleotide-excision repair, DNA gap filling (GO:0006297)3.24711974
45CENP-A containing nucleosome assembly (GO:0034080)3.23781061
46exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.22837595
47cytochrome complex assembly (GO:0017004)3.21778312
48ribosome biogenesis (GO:0042254)3.20871379
49L-fucose catabolic process (GO:0042355)3.20804393
50fucose catabolic process (GO:0019317)3.20804393
51L-fucose metabolic process (GO:0042354)3.20804393
52pseudouridine synthesis (GO:0001522)3.18837956
53RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.17863162
54serine family amino acid metabolic process (GO:0009069)3.13569522
55mitochondrial respiratory chain complex assembly (GO:0033108)3.11900837
56peptidyl-histidine modification (GO:0018202)3.10373342
57mitotic chromosome condensation (GO:0007076)3.08607207
58protein localization to chromosome, centromeric region (GO:0071459)3.07670708
59pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)3.06991049
60recombinational repair (GO:0000725)3.06520162
61DNA replication-independent nucleosome assembly (GO:0006336)3.05367899
62DNA replication-independent nucleosome organization (GO:0034724)3.05367899
63DNA deamination (GO:0045006)3.04887149
64double-strand break repair via homologous recombination (GO:0000724)3.03971189
65rRNA catabolic process (GO:0016075)3.02752156
66DNA duplex unwinding (GO:0032508)3.02688511
67rRNA modification (GO:0000154)3.01837979
68serine family amino acid catabolic process (GO:0009071)3.01673760
69protein complex biogenesis (GO:0070271)3.00815921
70DNA geometric change (GO:0032392)3.00602638
71regulation of double-strand break repair via homologous recombination (GO:0010569)3.00212466
72kinetochore organization (GO:0051383)3.00193926
73mitotic sister chromatid segregation (GO:0000070)2.99794017
74metaphase plate congression (GO:0051310)2.98965406
75mitochondrial respiratory chain complex I assembly (GO:0032981)2.98824443
76NADH dehydrogenase complex assembly (GO:0010257)2.98824443
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.98824443
78pore complex assembly (GO:0046931)2.94156386
79pteridine-containing compound biosynthetic process (GO:0042559)2.93843175
80dosage compensation (GO:0007549)2.93543076
81somatic diversification of immune receptors via somatic mutation (GO:0002566)2.92848622
82somatic hypermutation of immunoglobulin genes (GO:0016446)2.92848622
83tRNA processing (GO:0008033)2.92652304
84positive regulation of chromosome segregation (GO:0051984)2.91932000
85ribosome assembly (GO:0042255)2.90369839
86mitochondrial RNA metabolic process (GO:0000959)2.90356913
87ribonucleoprotein complex biogenesis (GO:0022613)2.89367765
88one-carbon metabolic process (GO:0006730)2.87725532
89regulation of nuclear cell cycle DNA replication (GO:0033262)2.87386333
90behavioral response to nicotine (GO:0035095)2.86706968
91L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85567240
92ubiquinone biosynthetic process (GO:0006744)2.84675221
93water-soluble vitamin biosynthetic process (GO:0042364)2.83443298
94somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.82562171
95isotype switching (GO:0045190)2.82562171
96somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.82562171
97spliceosomal snRNP assembly (GO:0000387)2.82283460
98pteridine-containing compound metabolic process (GO:0042558)2.81224467
99RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.81121032
100tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.81121032
101regulation of spindle organization (GO:0090224)2.80909888
102sister chromatid segregation (GO:0000819)2.80757102
103viral transcription (GO:0019083)2.78788090
104translational termination (GO:0006415)2.77969752
105pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.77500281
106rRNA processing (GO:0006364)2.77116812
107telomere organization (GO:0032200)2.76515889
108telomere maintenance (GO:0000723)2.75815049
109attachment of spindle microtubules to kinetochore (GO:0008608)2.75789647
110translational initiation (GO:0006413)2.75214331
111base-excision repair (GO:0006284)2.74767906
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.73884738
113L-phenylalanine metabolic process (GO:0006558)2.73884738
114reciprocal meiotic recombination (GO:0007131)2.72622868
115reciprocal DNA recombination (GO:0035825)2.72622868
116negative regulation of histone methylation (GO:0031061)2.72616845
117rRNA methylation (GO:0031167)2.71397368
118tRNA modification (GO:0006400)2.71254589
119kynurenine metabolic process (GO:0070189)2.71145562
120histone exchange (GO:0043486)2.70770587
121organelle disassembly (GO:1903008)2.70669205
122deoxyribonucleotide biosynthetic process (GO:0009263)2.70078020
123deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.70027802
124regulation of histone H3-K9 methylation (GO:0051570)2.69136787
125rRNA metabolic process (GO:0016072)2.68784101
126ribosomal large subunit biogenesis (GO:0042273)2.68443883
127nucleoside salvage (GO:0043174)2.67487844
128L-phenylalanine catabolic process (GO:0006559)2.67050740
129erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.67050740
130synapsis (GO:0007129)2.66926364
131cell cycle G1/S phase transition (GO:0044843)2.66649872
132G1/S transition of mitotic cell cycle (GO:0000082)2.66649872
133establishment of protein localization to mitochondrial membrane (GO:0090151)2.66505890
134translational elongation (GO:0006414)2.66154010
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.65291695
136transcription-coupled nucleotide-excision repair (GO:0006283)2.64939195
137GMP metabolic process (GO:0046037)2.64858289
138viral mRNA export from host cell nucleus (GO:0046784)2.64160737
139nuclear envelope organization (GO:0006998)2.63632513
140proteasome assembly (GO:0043248)2.63237579
141ubiquinone metabolic process (GO:0006743)2.62819118
142establishment of chromosome localization (GO:0051303)2.62368995
143ncRNA catabolic process (GO:0034661)2.61268369
144glyoxylate metabolic process (GO:0046487)2.61195313
145kinetochore assembly (GO:0051382)2.60810172
146tRNA metabolic process (GO:0006399)2.60810094
147negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.60483822
148sulfur amino acid biosynthetic process (GO:0000097)2.60473424
149postreplication repair (GO:0006301)2.60130830
150cullin deneddylation (GO:0010388)2.59743207
151transcription elongation from RNA polymerase III promoter (GO:0006385)2.59735205
152termination of RNA polymerase III transcription (GO:0006386)2.59735205
153aromatic amino acid family catabolic process (GO:0009074)2.59722549
154negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)2.59662509
155maturation of 5.8S rRNA (GO:0000460)2.59027515
156regulation of centrosome cycle (GO:0046605)2.58822592
157neural tube formation (GO:0001841)2.57373578
158regulation of DNA endoreduplication (GO:0032875)2.57046679
159somatic diversification of immunoglobulins (GO:0016445)2.55902165
160DNA catabolic process, exonucleolytic (GO:0000738)2.53092561
161tryptophan catabolic process (GO:0006569)2.52575779
162indole-containing compound catabolic process (GO:0042436)2.52575779
163indolalkylamine catabolic process (GO:0046218)2.52575779
164regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.51677855
165positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.50784292
166platelet dense granule organization (GO:0060155)2.50075214
167protein deneddylation (GO:0000338)2.48755740
168response to pheromone (GO:0019236)2.47828408
169protein K11-linked deubiquitination (GO:0035871)2.47221380
170indolalkylamine metabolic process (GO:0006586)2.45372769
171methionine biosynthetic process (GO:0009086)2.43685260
172protein-cofactor linkage (GO:0018065)2.43103163
173ncRNA processing (GO:0034470)2.42592250
174translesion synthesis (GO:0019985)2.42553750
175tryptophan metabolic process (GO:0006568)2.42038254
176negative regulation of telomere maintenance (GO:0032205)2.41281662
177ncRNA metabolic process (GO:0034660)2.40950635
178RNA phosphodiester bond hydrolysis (GO:0090501)2.40221936
179RNA phosphodiester bond hydrolysis, endonucleolytic (GO:0090502)2.39825577
180signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.39051479
181signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.39051479
182signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.39051479
183somatic diversification of immune receptors (GO:0002200)2.38415725
184DNA recombination (GO:0006310)2.36869809

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.22670955
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.92898515
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.70536838
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56382786
5E2F4_17652178_ChIP-ChIP_JURKAT_Human3.49463820
6ZNF274_21170338_ChIP-Seq_K562_Hela3.09584387
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.98577639
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.86342280
9* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.80777734
10MYC_19079543_ChIP-ChIP_MESCs_Mouse2.76752237
11MYC_18358816_ChIP-ChIP_MESCs_Mouse2.71675546
12* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.68403589
13* EST1_17652178_ChIP-ChIP_JURKAT_Human2.58928581
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.52045861
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.47215048
16* ETS1_20019798_ChIP-Seq_JURKAT_Human2.46028537
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.41224281
18GABP_17652178_ChIP-ChIP_JURKAT_Human2.33812096
19HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.26060043
20XRN2_22483619_ChIP-Seq_HELA_Human2.25592989
21NELFA_20434984_ChIP-Seq_ESCs_Mouse2.24084837
22VDR_22108803_ChIP-Seq_LS180_Human2.22535760
23AR_21909140_ChIP-Seq_LNCAP_Human2.15770807
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.10423643
25EGR1_19374776_ChIP-ChIP_THP-1_Human2.01040492
26CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94128829
27VDR_23849224_ChIP-Seq_CD4+_Human1.93764260
28E2F1_21310950_ChIP-Seq_MCF-7_Human1.90739237
29* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.90014348
30DCP1A_22483619_ChIP-Seq_HELA_Human1.88062533
31* FOXP3_21729870_ChIP-Seq_TREG_Human1.87353866
32NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84974838
33MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84836205
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79487814
35ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79180115
36EWS_26573619_Chip-Seq_HEK293_Human1.79085728
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.78322903
38CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.76308766
39GABP_19822575_ChIP-Seq_HepG2_Human1.73640058
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.73614069
41MYC_22102868_ChIP-Seq_BL_Human1.69881854
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.67309818
43CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.66011709
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.64072903
45TTF2_22483619_ChIP-Seq_HELA_Human1.61372378
46* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60544640
47NANOG_18555785_ChIP-Seq_MESCs_Mouse1.56744812
48* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.55154546
49SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.54513564
50FUS_26573619_Chip-Seq_HEK293_Human1.54374204
51* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54122594
52YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.53910459
53IGF1R_20145208_ChIP-Seq_DFB_Human1.53761729
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.53471176
55CIITA_25753668_ChIP-Seq_RAJI_Human1.53209055
56PPARA_22158963_ChIP-Seq_LIVER_Mouse1.52868478
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.49957956
58IRF1_19129219_ChIP-ChIP_H3396_Human1.48699794
59ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.47788817
60RXR_22158963_ChIP-Seq_LIVER_Mouse1.47262612
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.46595535
62GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44913744
63KDM5A_27292631_Chip-Seq_BREAST_Human1.44475798
64EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.41560310
65IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.40727170
66* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39262579
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.37038257
68CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.36013561
69HOXB4_20404135_ChIP-ChIP_EML_Mouse1.34608039
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.34455481
71* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33835154
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.32894133
73POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.31191204
74BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.28247458
75TP53_22573176_ChIP-Seq_HFKS_Human1.24907864
76IRF8_22096565_ChIP-ChIP_GC-B_Human1.24878230
77POU3F2_20337985_ChIP-ChIP_501MEL_Human1.24099143
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.23551067
79KLF4_18555785_ChIP-Seq_MESCs_Mouse1.22206116
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.21332945
81ELK1_19687146_ChIP-ChIP_HELA_Human1.20914672
82E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.19474498
83STAT3_1855785_ChIP-Seq_MESCs_Mouse1.17067929
84IRF8_21731497_ChIP-ChIP_J774_Mouse1.16827703
85GATA3_26560356_Chip-Seq_TH2_Human1.16442291
86ER_23166858_ChIP-Seq_MCF-7_Human1.15924245
87PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.15867653
88PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15835633
89POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.14848567
90PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.12927028
91* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.12751478
92SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.12383988
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09428255
94SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.07820710
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.05534487
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05395800
97SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04714775
98FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.03643763
99HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00936248
100FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00797822
101TFEB_21752829_ChIP-Seq_HELA_Human1.00676158
102KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00568514
103P300_19829295_ChIP-Seq_ESCs_Human0.98831174
104SPI1_23547873_ChIP-Seq_NB4_Human0.98179466
105TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.97096783
106VDR_21846776_ChIP-Seq_THP-1_Human0.97021439
107RBPJ_22232070_ChIP-Seq_NCS_Mouse0.96293928
108MYC_18940864_ChIP-ChIP_HL60_Human0.95786263
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95038857
110PCGF2_27294783_Chip-Seq_ESCs_Mouse0.93338176
111SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.93006388
112GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91182829
113* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.90130830
114HOXB7_26014856_ChIP-Seq_BT474_Human0.89495455
115CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.87921157
116KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87733402
117CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.86622743
118FOXA1_25329375_ChIP-Seq_VCAP_Human0.86435865
119FOXA1_27270436_Chip-Seq_PROSTATE_Human0.86435865
120GATA3_21878914_ChIP-Seq_MCF-7_Human0.85159879
121GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.84881887
122TP63_19390658_ChIP-ChIP_HaCaT_Human0.84620744
123HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.84398921
124NANOG_19829295_ChIP-Seq_ESCs_Human0.84180058
125SOX2_19829295_ChIP-Seq_ESCs_Human0.84180058
126AR_20517297_ChIP-Seq_VCAP_Human0.83273796
127* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.83211925
128TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.83165791
129NOTCH1_21737748_ChIP-Seq_TLL_Human0.82940610
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.82930145
131GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.82738518
132NCOR_22424771_ChIP-Seq_293T_Human0.82305980
133MYB_26560356_Chip-Seq_TH2_Human0.81253043
134ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80800937
135OCT4_18692474_ChIP-Seq_MEFs_Mouse0.79134430
136* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.79023585

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability4.34891306
2MP0003693_abnormal_embryo_hatching4.31163538
3MP0002139_abnormal_hepatobiliary_system3.92881523
4MP0008057_abnormal_DNA_replication3.80431318
5MP0003111_abnormal_nucleus_morphology3.80137591
6MP0003806_abnormal_nucleotide_metabolis3.67846178
7MP0004957_abnormal_blastocyst_morpholog3.48131343
8MP0005360_urolithiasis3.46637263
9MP0003077_abnormal_cell_cycle3.24354509
10MP0005365_abnormal_bile_salt2.99756068
11MP0005085_abnormal_gallbladder_physiolo2.85919504
12MP0003136_yellow_coat_color2.78826701
13MP0002163_abnormal_gland_morphology2.76794140
14MP0008058_abnormal_DNA_repair2.75745381
15MP0000569_abnormal_digit_pigmentation2.31197980
16MP0002396_abnormal_hematopoietic_system2.26771899
17MP0002102_abnormal_ear_morphology2.19526091
18MP0008875_abnormal_xenobiotic_pharmacok2.18276660
19MP0008877_abnormal_DNA_methylation2.18235118
20MP0008007_abnormal_cellular_replicative2.14731450
21MP0001730_embryonic_growth_arrest2.12425079
22MP0000372_irregular_coat_pigmentation1.99530027
23MP0003195_calcinosis1.99285952
24MP0006072_abnormal_retinal_apoptosis1.95706841
25MP0005379_endocrine/exocrine_gland_phen1.94881501
26MP0003786_premature_aging1.94613300
27MP0008932_abnormal_embryonic_tissue1.92499716
28MP0000350_abnormal_cell_proliferation1.88369558
29MP0001986_abnormal_taste_sensitivity1.81863612
30MP0010030_abnormal_orbit_morphology1.77577778
31MP0010352_gastrointestinal_tract_polyps1.68862741
32MP0009840_abnormal_foam_cell1.68415436
33MP0001873_stomach_inflammation1.65844073
34MP0010307_abnormal_tumor_latency1.63816645
35MP0002837_dystrophic_cardiac_calcinosis1.63338376
36MP0003123_paternal_imprinting1.62895804
37MP0003656_abnormal_erythrocyte_physiolo1.62530937
38MP0002277_abnormal_respiratory_mucosa1.62451498
39MP0005671_abnormal_response_to1.62230738
40MP0005380_embryogenesis_phenotype1.52056764
41MP0001672_abnormal_embryogenesis/_devel1.52056764
42MP0001835_abnormal_antigen_presentation1.50433329
43MP0010329_abnormal_lipoprotein_level1.49022630
44MP0005551_abnormal_eye_electrophysiolog1.47122532
45MP0009672_abnormal_birth_weight1.46449975
46MP0009697_abnormal_copulation1.46393228
47MP0001697_abnormal_embryo_size1.44669623
48MP0003718_maternal_effect1.43932881
49MP0005075_abnormal_melanosome_morpholog1.42335421
50MP0001800_abnormal_humoral_immune1.41047215
51MP0003984_embryonic_growth_retardation1.40706072
52MP0009053_abnormal_anal_canal1.40220180
53MP0004142_abnormal_muscle_tone1.39701069
54MP0002088_abnormal_embryonic_growth/wei1.39179153
55MP0005174_abnormal_tail_pigmentation1.37768262
56MP0000609_abnormal_liver_physiology1.34936911
57MP0002019_abnormal_tumor_incidence1.33787979
58MP0005310_abnormal_salivary_gland1.32502008
59MP0005253_abnormal_eye_physiology1.32259435
60MP0002080_prenatal_lethality1.31447465
61MP0003252_abnormal_bile_duct1.29353850
62MP0000427_abnormal_hair_cycle1.28121875
63MP0004147_increased_porphyrin_level1.27883463
64MP0002148_abnormal_hypersensitivity_rea1.27039226
65MP0009785_altered_susceptibility_to1.26580290
66MP0003890_abnormal_embryonic-extraembry1.26533573
67MP0003186_abnormal_redox_activity1.24980151
68MP0004197_abnormal_fetal_growth/weight/1.24160129
69MP0000313_abnormal_cell_death1.23556010
70MP0002254_reproductive_system_inflammat1.23540688
71MP0001545_abnormal_hematopoietic_system1.23317264
72MP0005397_hematopoietic_system_phenotyp1.23317264
73MP0001968_abnormal_touch/_nociception1.22703388
74MP0002095_abnormal_skin_pigmentation1.21358049
75MP0005332_abnormal_amino_acid1.20473412
76MP0001764_abnormal_homeostasis1.18995176
77MP0009764_decreased_sensitivity_to1.18951517
78MP0003646_muscle_fatigue1.18771796
79MP0000015_abnormal_ear_pigmentation1.17558006
80MP0005083_abnormal_biliary_tract1.17422938
81MP0002086_abnormal_extraembryonic_tissu1.16684952
82MP0002723_abnormal_immune_serum1.16096205
83MP0000685_abnormal_immune_system1.16043643
84MP0004381_abnormal_hair_follicle1.14912199
85MP0006035_abnormal_mitochondrial_morpho1.14700004
86MP0002452_abnormal_antigen_presenting1.13702244
87MP0000598_abnormal_liver_morphology1.13020930
88MP0003724_increased_susceptibility_to1.12313231
89MP0001790_abnormal_immune_system1.11638481
90MP0005387_immune_system_phenotype1.11638481
91MP0002420_abnormal_adaptive_immunity1.09617399
92MP0005084_abnormal_gallbladder_morpholo1.09185542
93MP0001819_abnormal_immune_cell1.08590482
94MP0002138_abnormal_hepatobiliary_system1.08286252
95MP0002009_preneoplasia1.08094438
96MP0002085_abnormal_embryonic_tissue1.05613407
97MP0005319_abnormal_enzyme/_coenzyme1.03538645
98MP0002938_white_spotting1.03496318
99MP0002736_abnormal_nociception_after1.03357729
100MP0005000_abnormal_immune_tolerance1.02854004
101MP0000490_abnormal_crypts_of1.01664682
102MP0002084_abnormal_developmental_patter1.01256742
103MP0008872_abnormal_physiological_respon1.01151081
104MP0009333_abnormal_splenocyte_physiolog0.98822494
105MP0002693_abnormal_pancreas_physiology0.98140402
106MP0006292_abnormal_olfactory_placode0.98121041
107MP0002928_abnormal_bile_duct0.97790245
108MP0002405_respiratory_system_inflammati0.97584020
109MP0004808_abnormal_hematopoietic_stem0.97029976
110MP0006036_abnormal_mitochondrial_physio0.96616330
111MP0000689_abnormal_spleen_morphology0.95968840
112MP0003787_abnormal_imprinting0.94747871
113MP0001919_abnormal_reproductive_system0.94610974
114MP0001485_abnormal_pinna_reflex0.92095168
115MP0001915_intracranial_hemorrhage0.91836697
116MP0002722_abnormal_immune_system0.91296259
117MP0002166_altered_tumor_susceptibility0.90765660
118MP0004742_abnormal_vestibular_system0.89802691
119MP0000716_abnormal_immune_system0.88853170
120MP0000358_abnormal_cell_content/0.86990723
121MP0004043_abnormal_pH_regulation0.86878624
122MP0005410_abnormal_fertilization0.86536179
123MP0002653_abnormal_ependyma_morphology0.86488798
124MP0003705_abnormal_hypodermis_morpholog0.85530658
125MP0000703_abnormal_thymus_morphology0.84393286
126MP0005076_abnormal_cell_differentiation0.84225374
127MP0005389_reproductive_system_phenotype0.82923329
128MP0005266_abnormal_metabolism0.82311478
129MP0008995_early_reproductive_senescence0.81888665
130MP0002398_abnormal_bone_marrow0.80998749
131MP0002006_tumorigenesis0.80870216
132MP0002210_abnormal_sex_determination0.80630696
133MP0001666_abnormal_nutrient_absorption0.79518601
134MP0001845_abnormal_inflammatory_respons0.79505150
135MP0003763_abnormal_thymus_physiology0.76082980
136MP0001145_abnormal_male_reproductive0.74809663
137MP0009703_decreased_birth_body0.74447393
138MP0002876_abnormal_thyroid_physiology0.74378715
139MP0005395_other_phenotype0.74001374
140MP0009765_abnormal_xenobiotic_induced0.73941543
141MP0003567_abnormal_fetal_cardiomyocyte0.71882353
142MP0001119_abnormal_female_reproductive0.70484082
143MP0003119_abnormal_digestive_system0.70275000
144MP0002132_abnormal_respiratory_system0.69187565
145MP0005451_abnormal_body_composition0.68143438
146MP0002970_abnormal_white_adipose0.66891233
147MP0000653_abnormal_sex_gland0.66874082
148MP0002429_abnormal_blood_cell0.66593314
149MP0005023_abnormal_wound_healing0.64297948
150MP0005408_hypopigmentation0.63096702
151MP0009763_increased_sensitivity_to0.62539220
152MP0005501_abnormal_skin_physiology0.61474427
153MP0003221_abnormal_cardiomyocyte_apopto0.61395922
154MP0002160_abnormal_reproductive_system0.61054469
155MP0005384_cellular_phenotype0.60189214
156MP0003121_genomic_imprinting0.59601353
157MP0008873_increased_physiological_sensi0.59411769
158MP0001853_heart_inflammation0.59085257
159MP0008789_abnormal_olfactory_epithelium0.57968074
160MP0003436_decreased_susceptibility_to0.57842940
161MP0001929_abnormal_gametogenesis0.56524205

Predicted human phenotypes

RankGene SetZ-score
1Hypobetalipoproteinemia (HP:0003563)4.37118376
2Abnormality of monocarboxylic acid metabolism (HP:0010996)4.11930628
3Abnormality of pyrimidine metabolism (HP:0004353)4.08377560
4Birth length less than 3rd percentile (HP:0003561)3.67043253
5Pancreatic cysts (HP:0001737)3.54731546
6Intrahepatic cholestasis (HP:0001406)3.51814414
7Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46145911
8Oral leukoplakia (HP:0002745)3.38985374
9Impulsivity (HP:0100710)3.23685297
10Abnormality of the anterior horn cell (HP:0006802)3.23495824
11Degeneration of anterior horn cells (HP:0002398)3.23495824
12Hyperglycinemia (HP:0002154)3.22472339
13Hypochromic microcytic anemia (HP:0004840)3.14441584
14Deep venous thrombosis (HP:0002625)3.13103347
15Congenital stationary night blindness (HP:0007642)3.08253656
16Breast hypoplasia (HP:0003187)3.07267196
17Pancreatic fibrosis (HP:0100732)2.95514064
18Reticulocytopenia (HP:0001896)2.94600894
19Molar tooth sign on MRI (HP:0002419)2.89379629
20Abnormality of midbrain morphology (HP:0002418)2.89379629
21Hypolipoproteinemia (HP:0010981)2.85834377
22Multiple enchondromatosis (HP:0005701)2.81198074
23Hyperammonemia (HP:0001987)2.76050432
24Prolonged partial thromboplastin time (HP:0003645)2.73959456
25Rough bone trabeculation (HP:0100670)2.73933206
26Increased CSF lactate (HP:0002490)2.71552874
273-Methylglutaconic aciduria (HP:0003535)2.69497854
28True hermaphroditism (HP:0010459)2.68878154
29Abnormal rod and cone electroretinograms (HP:0008323)2.67689751
30Pendular nystagmus (HP:0012043)2.67561717
31Abnormality of the renal cortex (HP:0011035)2.65982730
32Progressive inability to walk (HP:0002505)2.65511111
33Xanthomatosis (HP:0000991)2.61153039
34Hepatocellular necrosis (HP:0001404)2.60092086
35Mitochondrial inheritance (HP:0001427)2.59460779
36Chromsome breakage (HP:0040012)2.58742040
37Abnormality of sulfur amino acid metabolism (HP:0004339)2.58696195
38Hyperglycinuria (HP:0003108)2.56648097
39Abnormality of serine family amino acid metabolism (HP:0010894)2.56244287
40Abnormality of glycine metabolism (HP:0010895)2.56244287
41Agnosia (HP:0010524)2.53443264
42Ependymoma (HP:0002888)2.53336305
43Abnormality of the pons (HP:0007361)2.53001444
44Intestinal atresia (HP:0011100)2.52672674
45Attenuation of retinal blood vessels (HP:0007843)2.51782250
46Increased hepatocellular lipid droplets (HP:0006565)2.50288353
47Lipid accumulation in hepatocytes (HP:0006561)2.49999262
48Abnormality of chromosome stability (HP:0003220)2.49415413
49Spastic diplegia (HP:0001264)2.49201150
50Type II lissencephaly (HP:0007260)2.48527708
51Stomatitis (HP:0010280)2.47482284
52Acute necrotizing encephalopathy (HP:0006965)2.47221053
53Abnormality of serum amino acid levels (HP:0003112)2.45264066
54Abnormality of the preputium (HP:0100587)2.45075955
55Hypoplasia of the pons (HP:0012110)2.44861368
56Abnormality of methionine metabolism (HP:0010901)2.43704704
57Abnormality of the labia minora (HP:0012880)2.42833919
58Abnormal number of erythroid precursors (HP:0012131)2.41161464
59Cerebral hypomyelination (HP:0006808)2.41105457
60Hypochromic anemia (HP:0001931)2.40805183
61Abnormality of cells of the erythroid lineage (HP:0012130)2.38762922
62Patellar aplasia (HP:0006443)2.37110226
63Rhabdomyosarcoma (HP:0002859)2.37076194
64Medulloblastoma (HP:0002885)2.32230826
65Hepatic necrosis (HP:0002605)2.30752834
66Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30641445
67Inability to walk (HP:0002540)2.26515486
68Large for gestational age (HP:0001520)2.24900993
69Abnormality of the heme biosynthetic pathway (HP:0010472)2.24354884
70Macrocytic anemia (HP:0001972)2.24257249
71Colon cancer (HP:0003003)2.23541279
72Meckel diverticulum (HP:0002245)2.22504121
73Abnormal biliary tract physiology (HP:0012439)2.22389800
74Bile duct proliferation (HP:0001408)2.22389800
75Abnormality of the ileum (HP:0001549)2.21047701
76Absent thumb (HP:0009777)2.19867264
77Abnormal mitochondria in muscle tissue (HP:0008316)2.17635109
78Progressive macrocephaly (HP:0004481)2.17539278
79Facial hemangioma (HP:0000329)2.17349438
80IgG deficiency (HP:0004315)2.16660162
81Aplasia/Hypoplasia of the patella (HP:0006498)2.16282363
82Sloping forehead (HP:0000340)2.16012432
83Amaurosis fugax (HP:0100576)2.15286544
84Selective tooth agenesis (HP:0001592)2.15274855
85Acute encephalopathy (HP:0006846)2.14871825
86Abnormality of B cell number (HP:0010975)2.13972540
87Abolished electroretinogram (ERG) (HP:0000550)2.13184890
88Absent rod-and cone-mediated responses on ERG (HP:0007688)2.12820222
89Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.12194338
90Neoplasm of the adrenal cortex (HP:0100641)2.11687632
91Atrophy/Degeneration involving motor neurons (HP:0007373)2.10528713
92Premature graying of hair (HP:0002216)2.10165833
93Nephronophthisis (HP:0000090)2.09347130
94Chronic hepatic failure (HP:0100626)2.09274630
95Premature ovarian failure (HP:0008209)2.08021148
96Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.07127506
97Abnormality of alanine metabolism (HP:0010916)2.07127506
98Hyperalaninemia (HP:0003348)2.07127506
99Thrombocytosis (HP:0001894)2.06309340
100Chromosomal breakage induced by crosslinking agents (HP:0003221)2.05752422
101Abnormality of the lower motor neuron (HP:0002366)2.05209727
102Squamous cell carcinoma (HP:0002860)2.03740035
103Aplasia/Hypoplasia of the uvula (HP:0010293)2.03338850
104Cellular immunodeficiency (HP:0005374)2.03293866
105Secondary amenorrhea (HP:0000869)2.02782287
106Hyperlipoproteinemia (HP:0010980)2.02658967
107Constricted visual fields (HP:0001133)2.02485702
108Myelodysplasia (HP:0002863)2.01288036
109Bone marrow hypocellularity (HP:0005528)2.01009302
110Neoplasm of the adrenal gland (HP:0100631)2.00367607
111Tubular atrophy (HP:0000092)2.00331320
112Upper motor neuron abnormality (HP:0002127)2.00199437
113Stomach cancer (HP:0012126)1.96563010
114Hypoalphalipoproteinemia (HP:0003233)1.96089903
115Hyperbilirubinemia (HP:0002904)1.95968235
116Neuroendocrine neoplasm (HP:0100634)1.95649184
117Neoplasm of the pancreas (HP:0002894)1.95593144
118Clubbing of toes (HP:0100760)1.95367963
119B lymphocytopenia (HP:0010976)1.95051668
120Volvulus (HP:0002580)1.94990123
121Increased serum pyruvate (HP:0003542)1.94387428
122Abnormality of glycolysis (HP:0004366)1.94387428
123Abnormality of aspartate family amino acid metabolism (HP:0010899)1.94145042
124Abnormal number of incisors (HP:0011064)1.93620824
125Oligodactyly (hands) (HP:0001180)1.93357919
126Horseshoe kidney (HP:0000085)1.93324520
127Decreased electroretinogram (ERG) amplitude (HP:0000654)1.93195337
128Lactic acidosis (HP:0003128)1.92887740
129Pallor (HP:0000980)1.92413218
130Renal cortical cysts (HP:0000803)1.91628328
131Abnormality of the renal medulla (HP:0100957)1.90687863
132Joint hemorrhage (HP:0005261)1.90029347
133Severe combined immunodeficiency (HP:0004430)1.89871081
134Carpal bone hypoplasia (HP:0001498)1.89767017
135Megaloblastic anemia (HP:0001889)1.89491472
136Abnormality of nucleobase metabolism (HP:0010932)1.89321323
137Abnormal trabecular bone morphology (HP:0100671)1.88918948
138Optic disc pallor (HP:0000543)1.88552319
139Increased nuchal translucency (HP:0010880)1.86511847
140Pancytopenia (HP:0001876)1.86507372
141Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.86423336
142Basal cell carcinoma (HP:0002671)1.86357697
143High anterior hairline (HP:0009890)1.86224466
144Furrowed tongue (HP:0000221)1.85911041
145Abnormality of reticulocytes (HP:0004312)1.85465611
146Abnormality of the motor neurons (HP:0002450)1.82316848
147Abnormal neuron morphology (HP:0012757)1.82316848
148Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79178758
149Abnormality of the duodenum (HP:0002246)1.78574711
150Lissencephaly (HP:0001339)1.77576672
151Increased serum lactate (HP:0002151)1.77234963
152Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76952766
153Abnormal protein N-linked glycosylation (HP:0012347)1.76952766
154Abnormal protein glycosylation (HP:0012346)1.76952766
155Abnormal glycosylation (HP:0012345)1.76952766
156Abnormality of the common coagulation pathway (HP:0010990)1.76470540
157Thyroiditis (HP:0100646)1.75970465
158Nausea (HP:0002018)1.75883820
159Abnormality of fatty-acid metabolism (HP:0004359)1.75834542
160Renal Fanconi syndrome (HP:0001994)1.75666521
161Abnormality of the metopic suture (HP:0005556)1.75628813
162Congenital, generalized hypertrichosis (HP:0004540)1.74833560
163Methylmalonic acidemia (HP:0002912)1.74768038
164Cerebellar dysplasia (HP:0007033)1.74587885
165Pheochromocytoma (HP:0002666)1.73197345
166Panhypogammaglobulinemia (HP:0003139)1.72609312
167Small intestinal stenosis (HP:0012848)1.72465936
168Duodenal stenosis (HP:0100867)1.72465936
169Complement deficiency (HP:0004431)1.72177308
170Ectopic kidney (HP:0000086)1.72134662
171Fat malabsorption (HP:0002630)1.71375953
172Hypercholesterolemia (HP:0003124)1.70848699
173Opisthotonus (HP:0002179)1.69747975
174Delayed CNS myelination (HP:0002188)1.69724515
175Trismus (HP:0000211)1.69552838
176Abnormal drinking behavior (HP:0030082)1.69235601
177Polydipsia (HP:0001959)1.69235601
178Type I transferrin isoform profile (HP:0003642)1.68365387
179Progressive microcephaly (HP:0000253)1.67881906
180Aplastic anemia (HP:0001915)1.67197855
181Bony spicule pigmentary retinopathy (HP:0007737)1.66558867
182IgM deficiency (HP:0002850)1.66481120
183Respiratory difficulties (HP:0002880)1.66363169

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.08225719
2FRK4.03723600
3WEE13.91683909
4CDC73.85734145
5EIF2AK12.98665650
6SRPK12.67825140
7NEK12.67500665
8NEK22.62550778
9BMPR1B2.55203428
10TSSK62.40894530
11TESK22.32268105
12WNK32.26868884
13TXK2.26530986
14TTK2.19560514
15PASK2.17689034
16ACVR1B2.17412647
17NUAK12.14149550
18ADRBK22.00473702
19FLT31.93138918
20BRSK21.89211422
21PINK11.89196546
22ATR1.88480117
23BCKDK1.88378254
24TAF11.87199603
25VRK21.86700677
26STK161.84783715
27CDK71.84400977
28PLK11.82060880
29PKN21.81091310
30TRIM281.72241411
31MST41.72070401
32MKNK11.65744149
33TLK11.63842917
34CAMKK21.57283363
35NME21.56548965
36PLK31.56147757
37CDK121.56051645
38AURKB1.51841208
39VRK11.47486590
40CDK41.47186016
41CCNB11.47116654
42IRAK41.39448659
43MAP4K21.35078761
44WNK41.33598680
45MAP4K11.32007684
46EIF2AK31.30624226
47BRSK11.30303576
48DYRK31.29728812
49MAP3K101.28804693
50RPS6KB21.24717058
51BRD41.24647216
52STK101.24387810
53CHEK21.21854609
54AURKA1.20982722
55TAOK31.16235007
56GRK11.14998985
57MAP3K81.14681909
58OXSR11.13993998
59CHEK11.12966230
60FGFR41.12250099
61MAP2K71.11595567
62SIK31.06543586
63PLK41.02875219
64RPS6KA41.01130352
65FGFR21.00789365
66MARK30.97713721
67EPHA20.96328547
68IKBKB0.96257978
69EPHA30.95930836
70NME10.93807472
71PAK40.92802437
72TGFBR10.92546257
73ATM0.91757189
74PIM10.91231836
75SCYL20.90748329
76GRK60.89288673
77CDK20.89144944
78RPS6KA50.88621391
79PBK0.87331438
80MAP3K40.86421318
81ERN10.85385800
82IRAK10.85334178
83TNIK0.84465596
84STK390.81249484
85ZAP700.79665472
86STK40.79231613
87CASK0.78733873
88CSNK2A20.76432706
89DAPK10.76135968
90NLK0.75006502
91EEF2K0.73033226
92MKNK20.72810227
93DYRK20.71441730
94CSF1R0.70357766
95CLK10.68179311
96CSNK2A10.67407737
97PIM20.67167705
98PAK30.66958073
99IKBKE0.65992829
100ERBB30.64509914
101CDK60.63460654
102TEC0.63449968
103CDK10.62801479
104EIF2AK20.62562432
105FES0.60845720
106CSNK1G30.60584455
107LRRK20.58495344
108PRKCQ0.58002233
109CSNK1G10.57632866
110PRKCI0.57128561
111CSNK1A1L0.53742462
112LIMK10.53092420
113BLK0.52390770
114MELK0.51952047
115MAP3K140.51502335
116MTOR0.51211361
117RPS6KB10.50892008
118MAP3K110.50593066
119BRAF0.50574465
120MAP2K30.50249431
121CDK80.48611479
122TESK10.48363481
123MAPK130.48117773
124PAK10.47727960
125INSRR0.45512267
126CAMK1D0.44996632
127MAPK110.44703016
128FGFR10.44640453
129STK38L0.43802956
130RPS6KA60.42872210
131ZAK0.42419229
132STK30.41766771
133RPS6KL10.41036778
134RPS6KC10.41036778
135CHUK0.40492834
136CSNK1G20.40036496
137KDR0.39380309
138ALK0.39377412
139TRIB30.39015007
140LCK0.36682825
141MAP2K60.36439094
142LYN0.35394528
143CSNK1E0.35148297
144ITK0.34762216
145PRKDC0.33492493
146MAPKAPK30.33044548
147ERBB20.31293835
148BTK0.31099381
149MAPK40.28985960
150RPS6KA10.28980606
151AKT20.28870065
152YES10.28119180
153SYK0.27834792

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.21351622
2Mismatch repair_Homo sapiens_hsa034303.53487751
3One carbon pool by folate_Homo sapiens_hsa006703.31190596
4Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.73017119
5Homologous recombination_Homo sapiens_hsa034402.55572009
6Base excision repair_Homo sapiens_hsa034102.51269579
7Spliceosome_Homo sapiens_hsa030402.38970190
8Proteasome_Homo sapiens_hsa030502.34273249
9RNA transport_Homo sapiens_hsa030132.30691461
10Primary bile acid biosynthesis_Homo sapiens_hsa001202.19491968
11RNA polymerase_Homo sapiens_hsa030202.17487225
12Oxidative phosphorylation_Homo sapiens_hsa001902.16449606
13Ribosome_Homo sapiens_hsa030102.15598772
14Nucleotide excision repair_Homo sapiens_hsa034202.15168945
15Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.14409746
16Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.12886626
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.10520209
18Protein export_Homo sapiens_hsa030602.03206083
19Cell cycle_Homo sapiens_hsa041101.99037957
20Pyrimidine metabolism_Homo sapiens_hsa002401.97614422
21Drug metabolism - other enzymes_Homo sapiens_hsa009831.90477393
22Parkinsons disease_Homo sapiens_hsa050121.80764752
23Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.79613305
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.79363122
25Selenocompound metabolism_Homo sapiens_hsa004501.78720394
26Cysteine and methionine metabolism_Homo sapiens_hsa002701.71974457
27Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65625619
28Primary immunodeficiency_Homo sapiens_hsa053401.65529605
29Biosynthesis of amino acids_Homo sapiens_hsa012301.62486098
30Cyanoamino acid metabolism_Homo sapiens_hsa004601.59548239
31Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.55668237
32Phototransduction_Homo sapiens_hsa047441.52847980
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.51903222
34Non-homologous end-joining_Homo sapiens_hsa034501.50222861
35Arginine biosynthesis_Homo sapiens_hsa002201.48894554
36Fanconi anemia pathway_Homo sapiens_hsa034601.47325068
37Folate biosynthesis_Homo sapiens_hsa007901.32493621
38Sulfur relay system_Homo sapiens_hsa041221.32004792
39Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.30638511
40Huntingtons disease_Homo sapiens_hsa050161.28922684
41Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.26052856
42Intestinal immune network for IgA production_Homo sapiens_hsa046721.23957918
43p53 signaling pathway_Homo sapiens_hsa041151.23949690
44RNA degradation_Homo sapiens_hsa030181.23202065
45Vitamin B6 metabolism_Homo sapiens_hsa007501.20598232
46Carbon metabolism_Homo sapiens_hsa012001.20313214
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.19792765
48Pentose and glucuronate interconversions_Homo sapiens_hsa000401.18233947
49Pentose phosphate pathway_Homo sapiens_hsa000301.18187040
50Tryptophan metabolism_Homo sapiens_hsa003801.12763634
51Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.08901136
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06696214
53Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.06346254
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.03064944
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.02223386
56Regulation of autophagy_Homo sapiens_hsa041401.02127316
57mRNA surveillance pathway_Homo sapiens_hsa030151.01454218
58Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.99409218
59Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.99209091
60Complement and coagulation cascades_Homo sapiens_hsa046100.98431451
61Chemical carcinogenesis_Homo sapiens_hsa052040.96149566
62Asthma_Homo sapiens_hsa053100.94814200
63Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.94723435
64Nitrogen metabolism_Homo sapiens_hsa009100.94393635
65Fatty acid degradation_Homo sapiens_hsa000710.93996340
66Peroxisome_Homo sapiens_hsa041460.93747948
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.93527679
68Alzheimers disease_Homo sapiens_hsa050100.92142683
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.92137382
70alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.91843154
71Steroid hormone biosynthesis_Homo sapiens_hsa001400.91630199
72Autoimmune thyroid disease_Homo sapiens_hsa053200.89294349
73Retinol metabolism_Homo sapiens_hsa008300.89143691
74Allograft rejection_Homo sapiens_hsa053300.88651845
75Systemic lupus erythematosus_Homo sapiens_hsa053220.87645142
76Basal transcription factors_Homo sapiens_hsa030220.86967324
77Type I diabetes mellitus_Homo sapiens_hsa049400.86152030
78Linoleic acid metabolism_Homo sapiens_hsa005910.84436063
79RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.84176915
80Ether lipid metabolism_Homo sapiens_hsa005650.83480164
81Glutathione metabolism_Homo sapiens_hsa004800.82195854
82Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81849308
83Purine metabolism_Homo sapiens_hsa002300.75909521
84Epstein-Barr virus infection_Homo sapiens_hsa051690.75649486
85Graft-versus-host disease_Homo sapiens_hsa053320.75405922
86Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73708607
87NF-kappa B signaling pathway_Homo sapiens_hsa040640.73667156
88Pyruvate metabolism_Homo sapiens_hsa006200.72137182
89Butanoate metabolism_Homo sapiens_hsa006500.71969247
90Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.67455402
91Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.64712526
92Lysine degradation_Homo sapiens_hsa003100.64029140
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63369677
94Propanoate metabolism_Homo sapiens_hsa006400.62964441
95Maturity onset diabetes of the young_Homo sapiens_hsa049500.61755006
96Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59960831
97Fatty acid metabolism_Homo sapiens_hsa012120.59025986
98Measles_Homo sapiens_hsa051620.57545113
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.57272721
100Sulfur metabolism_Homo sapiens_hsa009200.56979685
101Staphylococcus aureus infection_Homo sapiens_hsa051500.55130091
102Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54853238
103Collecting duct acid secretion_Homo sapiens_hsa049660.54236366
104Steroid biosynthesis_Homo sapiens_hsa001000.53388934
105Herpes simplex infection_Homo sapiens_hsa051680.52967861
106Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.52157324
107beta-Alanine metabolism_Homo sapiens_hsa004100.50543849
108Olfactory transduction_Homo sapiens_hsa047400.49432167
109Viral carcinogenesis_Homo sapiens_hsa052030.48461818
110Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.48167445
111Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46504428
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.45947112
113T cell receptor signaling pathway_Homo sapiens_hsa046600.45638665
114Phenylalanine metabolism_Homo sapiens_hsa003600.45499277
115Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45349419
116Arginine and proline metabolism_Homo sapiens_hsa003300.45072320
117Metabolic pathways_Homo sapiens_hsa011000.43902710
118Caffeine metabolism_Homo sapiens_hsa002320.43044897
119Antigen processing and presentation_Homo sapiens_hsa046120.42949593
120Tyrosine metabolism_Homo sapiens_hsa003500.42474907
121Fructose and mannose metabolism_Homo sapiens_hsa000510.41186635
122Galactose metabolism_Homo sapiens_hsa000520.39699584
123Rheumatoid arthritis_Homo sapiens_hsa053230.39116908
124Hematopoietic cell lineage_Homo sapiens_hsa046400.39057913
125PPAR signaling pathway_Homo sapiens_hsa033200.38284057
126Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37549985
127Oocyte meiosis_Homo sapiens_hsa041140.36189917
128Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.35270147
129Starch and sucrose metabolism_Homo sapiens_hsa005000.34558788
130Alcoholism_Homo sapiens_hsa050340.34220474
131MicroRNAs in cancer_Homo sapiens_hsa052060.32540803
132Histidine metabolism_Homo sapiens_hsa003400.29418860
133Legionellosis_Homo sapiens_hsa051340.29356087
134Fat digestion and absorption_Homo sapiens_hsa049750.28612214
135Circadian rhythm_Homo sapiens_hsa047100.26649308
136Taste transduction_Homo sapiens_hsa047420.25130372
137Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.24087142
138Arachidonic acid metabolism_Homo sapiens_hsa005900.22930713
139Fatty acid elongation_Homo sapiens_hsa000620.22211212
140Jak-STAT signaling pathway_Homo sapiens_hsa046300.19811496
141Vitamin digestion and absorption_Homo sapiens_hsa049770.19420091
142HTLV-I infection_Homo sapiens_hsa051660.18595396
143Apoptosis_Homo sapiens_hsa042100.18539347
144Tuberculosis_Homo sapiens_hsa051520.17563848
145Thyroid cancer_Homo sapiens_hsa052160.16119657
146ABC transporters_Homo sapiens_hsa020100.14252364
147Central carbon metabolism in cancer_Homo sapiens_hsa052300.13693414

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