CWH43

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation via MHC class Ib (GO:0002475)9.38521856
2regulation of antigen processing and presentation of peptide antigen (GO:0002583)9.25454481
3antigen processing and presentation of endogenous antigen (GO:0019883)8.55892852
4bundle of His cell to Purkinje myocyte communication (GO:0086069)7.03033483
5hemidesmosome assembly (GO:0031581)6.48715228
6gap junction assembly (GO:0016264)5.39374235
7long-chain fatty acid biosynthetic process (GO:0042759)5.23605205
8regulation of water loss via skin (GO:0033561)5.06806775
9regulation of clathrin-mediated endocytosis (GO:2000369)4.98620735
10establishment of skin barrier (GO:0061436)4.92035535
11axonemal dynein complex assembly (GO:0070286)4.81562047
12intermediate filament cytoskeleton organization (GO:0045104)4.74484994
13lipoxygenase pathway (GO:0019372)4.62902107
14intermediate filament-based process (GO:0045103)4.57262631
15cilium or flagellum-dependent cell motility (GO:0001539)4.55154789
16linoleic acid metabolic process (GO:0043651)4.54996131
17multicellular organismal water homeostasis (GO:0050891)4.49635010
18chemical homeostasis within a tissue (GO:0048875)4.37046394
19epithelial cell differentiation involved in prostate gland development (GO:0060742)4.31228074
20branching involved in prostate gland morphogenesis (GO:0060442)4.22883561
21sphingoid metabolic process (GO:0046519)4.20466777
22maintenance of gastrointestinal epithelium (GO:0030277)4.18040526
23sulfur amino acid catabolic process (GO:0000098)4.17009764
24hair cycle (GO:0042633)4.14335543
25molting cycle (GO:0042303)4.14335543
26surfactant homeostasis (GO:0043129)4.14242442
27positive regulation of antigen processing and presentation (GO:0002579)4.13712373
28establishment of planar polarity (GO:0001736)4.13190660
29establishment of tissue polarity (GO:0007164)4.13190660
30phosphatidylinositol acyl-chain remodeling (GO:0036149)4.06751242
31regulation of acrosome reaction (GO:0060046)4.01263683
32water homeostasis (GO:0030104)3.90981822
33fusion of sperm to egg plasma membrane (GO:0007342)3.90949044
34keratinocyte development (GO:0003334)3.89836530
35keratinocyte proliferation (GO:0043616)3.89201101
36regulation of phospholipase A2 activity (GO:0032429)3.82978783
37epithelial cell maturation (GO:0002070)3.78656222
38cellular copper ion homeostasis (GO:0006878)3.77160430
39skin morphogenesis (GO:0043589)3.76639343
40intestinal epithelial cell development (GO:0060576)3.75872662
41keratinization (GO:0031424)3.71621334
42prostate gland epithelium morphogenesis (GO:0060740)3.67749110
43intermediate filament organization (GO:0045109)3.65911876
44cell-substrate junction assembly (GO:0007044)3.63664842
45keratinocyte differentiation (GO:0030216)3.61185158
46phosphatidylethanolamine acyl-chain remodeling (GO:0036152)3.59968404
47peptidyl-tyrosine autophosphorylation (GO:0038083)3.55596661
48epithelial structure maintenance (GO:0010669)3.53524715
49regulation of keratinocyte proliferation (GO:0010837)3.52744595
50atrioventricular valve morphogenesis (GO:0003181)3.50281549
51polarized epithelial cell differentiation (GO:0030859)3.47251691
52epidermal cell differentiation (GO:0009913)3.42272333
53detection of bacterium (GO:0016045)3.42219189
54cilium movement (GO:0003341)3.37543175
55regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.37449199
56positive regulation of epidermal cell differentiation (GO:0045606)3.33495845
57cytoskeletal anchoring at plasma membrane (GO:0007016)3.33135593
58sphingosine metabolic process (GO:0006670)3.31615640
59epidermis development (GO:0008544)3.30845868
60lateral sprouting from an epithelium (GO:0060601)3.30007252
61ventricular cardiac muscle cell action potential (GO:0086005)3.29285334
62positive regulation of epidermis development (GO:0045684)3.27303669
63diol metabolic process (GO:0034311)3.26208248
64phosphatidylglycerol acyl-chain remodeling (GO:0036148)3.24579502
65regulation of antigen processing and presentation (GO:0002577)3.22764571
66G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.19397195
67regulation of keratinocyte differentiation (GO:0045616)3.18357254
68phosphatidylcholine acyl-chain remodeling (GO:0036151)3.16728815
69apical protein localization (GO:0045176)3.16669496
70glutathione derivative biosynthetic process (GO:1901687)3.13806617
71glutathione derivative metabolic process (GO:1901685)3.13806617
72ectoderm development (GO:0007398)3.13637363
73detection of other organism (GO:0098543)3.09546741
74motile cilium assembly (GO:0044458)3.06059021
75negative regulation of cell fate specification (GO:0009996)3.04573575
76peptide cross-linking (GO:0018149)3.03444715
77O-glycan processing (GO:0016266)3.01708861
78iron ion import (GO:0097286)3.01267243
79pyrimidine-containing compound transmembrane transport (GO:0072531)3.00719995
80epithelium development (GO:0060429)3.00422636
81negative regulation of interferon-gamma production (GO:0032689)3.00066257
82regulation of glucocorticoid metabolic process (GO:0031943)2.99285517
83long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.99141293
84interferon-gamma secretion (GO:0072643)2.98995876
85artery development (GO:0060840)2.95386316
86copper ion homeostasis (GO:0055070)2.94228436
87plasma membrane fusion (GO:0045026)2.93241426
88ethanol metabolic process (GO:0006067)2.92643310
89negative regulation of hormone biosynthetic process (GO:0032353)2.92254033
90negative regulation of hormone metabolic process (GO:0032351)2.92254033
91calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.92057038
92hair cell differentiation (GO:0035315)2.91751331
93epithelial cell-cell adhesion (GO:0090136)2.90234780
94endocardial cushion morphogenesis (GO:0003203)2.89947319
95alditol phosphate metabolic process (GO:0052646)2.89209260
96negative regulation of receptor-mediated endocytosis (GO:0048261)2.88665584
97hypotonic response (GO:0006971)2.86574381
98cyclooxygenase pathway (GO:0019371)2.86033379
99regulation of apoptotic process involved in morphogenesis (GO:1902337)2.82615574
100sodium ion homeostasis (GO:0055078)2.82148143
101cell communication involved in cardiac conduction (GO:0086065)2.80025317
102regulation of nephron tubule epithelial cell differentiation (GO:0072182)2.78953219
103positive regulation of keratinocyte differentiation (GO:0045618)2.78001093
104one-carbon compound transport (GO:0019755)2.72298675
105sequestering of metal ion (GO:0051238)2.71082835
106copper ion transport (GO:0006825)2.70729378
107retinol metabolic process (GO:0042572)2.70200644
108regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.69470002
109positive regulation of osteoblast proliferation (GO:0033690)2.68433957
110regulation of heart rate by cardiac conduction (GO:0086091)2.67925106
111hair follicle morphogenesis (GO:0031069)2.67658766
112collecting duct development (GO:0072044)2.67610786
113fucose catabolic process (GO:0019317)2.65666458
114L-fucose metabolic process (GO:0042354)2.65666458
115L-fucose catabolic process (GO:0042355)2.65666458
116regulation of epidermis development (GO:0045682)2.64745068
117protein autoprocessing (GO:0016540)2.62970688
118epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62814909
119mesenchyme morphogenesis (GO:0072132)2.61936767
120primary alcohol catabolic process (GO:0034310)2.60586167
121regulation of steroid hormone biosynthetic process (GO:0090030)2.59392068
122positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.59381647
123prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060522.59366442
124ethanol oxidation (GO:0006069)2.58929438
125asymmetric protein localization (GO:0008105)2.58462566
126regulation of natural killer cell differentiation (GO:0032823)2.57978422
127ceramide biosynthetic process (GO:0046513)2.57640941
128excretion (GO:0007588)2.57009790
129negative regulation of keratinocyte proliferation (GO:0010839)2.56699617
130negative regulation of cell fate commitment (GO:0010454)2.56508320
131fatty acid elongation (GO:0030497)2.56418873
132phospholipid scrambling (GO:0017121)2.56192823
133cysteine metabolic process (GO:0006534)2.55909209
134regulation of transforming growth factor beta1 production (GO:0032908)2.55843912
135regulation of protein localization to cell surface (GO:2000008)2.55810991
136regulation of Cdc42 GTPase activity (GO:0043088)2.54990295
137fatty-acyl-CoA biosynthetic process (GO:0046949)2.54071045
138photoreceptor cell differentiation (GO:0046530)2.53332375
139eye photoreceptor cell differentiation (GO:0001754)2.53332375
1403-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.52427322
141purine ribonucleoside bisphosphate metabolic process (GO:0034035)2.52427322
142cardiac conduction (GO:0061337)2.51849520
143lung lobe morphogenesis (GO:0060463)2.51164058
144regulation of hydrogen peroxide metabolic process (GO:0010310)2.50265807
145phosphatidylserine acyl-chain remodeling (GO:0036150)2.49314008
146primary alcohol metabolic process (GO:0034308)2.46891145
147nephron tubule formation (GO:0072079)2.46088858
148negative regulation of protein autophosphorylation (GO:0031953)2.45919546
149response to phenylpropanoid (GO:0080184)2.45652677
150glandular epithelial cell differentiation (GO:0002067)2.45048515
151renal system process involved in regulation of blood volume (GO:0001977)2.44803442
152phosphatidylserine metabolic process (GO:0006658)2.44381704
153regulation of cell fate specification (GO:0042659)2.43402997
154antibacterial humoral response (GO:0019731)2.43047288
155renal absorption (GO:0070293)2.41411535
156regulation of chemokine secretion (GO:0090196)2.41254602
157cell-cell junction assembly (GO:0007043)2.40079902
158epithelial cilium movement (GO:0003351)2.39631483
159tight junction assembly (GO:0070830)2.39536474
160regulation of skeletal muscle contraction (GO:0014819)2.37870624
161endothelial cell chemotaxis (GO:0035767)2.37332257
162regulation of epidermal cell differentiation (GO:0045604)2.36415266
163long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.35838032
164antimicrobial humoral response (GO:0019730)2.33020298
165planar cell polarity pathway involved in neural tube closure (GO:0090179)2.31466625
166antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)10.4816389
167antigen processing and presentation of endogenous peptide antigen (GO:0002483)10.4816389
168desmosome organization (GO:0002934)10.3171007

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human9.45886674
2TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse5.55529137
3GATA1_22025678_ChIP-Seq_K562_Human4.45323543
4ESR1_21235772_ChIP-Seq_MCF-7_Human3.66816783
5ESR2_21235772_ChIP-Seq_MCF-7_Human2.92524646
6TRIM28_21343339_ChIP-Seq_HEK293_Human2.79025503
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.50456046
8SOX2_20726797_ChIP-Seq_SW620_Human2.21815781
9SOX9_24532713_ChIP-Seq_HFSC_Mouse2.18174900
10ZNF263_19887448_ChIP-Seq_K562_Human2.16877535
11* SOX2_27498859_Chip-Seq_STOMACH_Mouse2.12596364
12P63_26484246_Chip-Seq_KERATINOCYTES_Human1.96708468
13ZNF217_24962896_ChIP-Seq_MCF-7_Human1.95401730
14PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87992732
15FOXO3_23340844_ChIP-Seq_DLD1_Human1.77582380
16CDX2_20551321_ChIP-Seq_CACO-2_Human1.74632770
17RARG_19884340_ChIP-ChIP_MEFs_Mouse1.70837857
18CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70252513
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.69575520
20SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.69575520
21TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.67192748
22FOXA1_25552417_ChIP-Seq_VCAP_Human1.63686418
23GATA4_25053715_ChIP-Seq_YYC3_Human1.60660915
24* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.59618323
25BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.53948930
26RUNX1_27514584_Chip-Seq_MCF-7_Human1.50534415
27AR_21909140_ChIP-Seq_LNCAP_Human1.49280813
28* AHR_22903824_ChIP-Seq_MCF-7_Human1.47772943
29TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.46941276
30FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.46701389
31ESR1_15608294_ChIP-ChIP_MCF-7_Human1.37271684
32KLF5_25053715_ChIP-Seq_YYC3_Human1.34575816
33STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.33902791
34ESR1_20079471_ChIP-ChIP_T-47D_Human1.32550903
35GATA6_25053715_ChIP-Seq_YYC3_Human1.31957314
36ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.28983532
37RACK7_27058665_Chip-Seq_MCF-7_Human1.28087884
38* TP63_23658742_ChIP-Seq_EP156T_Human1.24159942
39AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.21422451
40CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.18902199
41SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.17551340
42TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17150115
43* ARNT_22903824_ChIP-Seq_MCF-7_Human1.16292467
44STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16159287
45GATA3_24758297_ChIP-Seq_MCF-7_Human1.15961772
46CJUN_26792858_Chip-Seq_BT549_Human1.15712017
47TP53_18474530_ChIP-ChIP_U2OS_Human1.14648987
48SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.14525329
49SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.14521024
50FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.13643305
51KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.12640609
52EP300_21415370_ChIP-Seq_HL-1_Mouse1.11801435
53EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09758912
54RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09758912
55* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09368610
56BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08323979
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.07964783
58ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07790446
59KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07578820
60NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.06723826
61ATF3_27146783_Chip-Seq_COLON_Human1.05206425
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.05184828
63AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04989310
64ERG_20517297_ChIP-Seq_VCAP_Human1.03646875
65SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.03116334
66EGR1_19032775_ChIP-ChIP_M12_Human1.02709126
67ERG_21242973_ChIP-ChIP_JURKAT_Human1.02451713
68LXR_22158963_ChIP-Seq_LIVER_Mouse1.02183274
69SMAD3_21741376_ChIP-Seq_HESCs_Human1.01092370
70TCF4_18268006_ChIP-ChIP_LS174T_Human1.00384499
71JARID2_20075857_ChIP-Seq_MESCs_Mouse1.00283492
72TP53_16413492_ChIP-PET_HCT116_Human0.99621216
73SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.98798517
74FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98559515
75CLOCK_20551151_ChIP-Seq_293T_Human0.98342337
76SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.98159204
77* LXR_22292898_ChIP-Seq_THP-1_Human0.97860165
78CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.95942641
79UBF1/2_26484160_Chip-Seq_HMECs_Human0.95647624
80PPARA_22158963_ChIP-Seq_LIVER_Mouse0.95103304
81ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.94858342
82CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.94357704
83DROSHA_22980978_ChIP-Seq_HELA_Human0.94018659
84FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.93699530
85EED_16625203_ChIP-ChIP_MESCs_Mouse0.93468358
86GATA2_21666600_ChIP-Seq_HMVEC_Human0.92702674
87HIF1A_21447827_ChIP-Seq_MCF-7_Human0.92243276
88BCAT_22108803_ChIP-Seq_LS180_Human0.91365047
89* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90656796
90CTNNB1_20460455_ChIP-Seq_HCT116_Human0.90471579
91TP63_22573176_ChIP-Seq_HFKS_Human0.89490774
92FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.89127909
93RXR_22158963_ChIP-Seq_LIVER_Mouse0.89071756
94* SMC4_20622854_ChIP-Seq_HELA_Human0.88985443
95PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87712761
96EZH2_27294783_Chip-Seq_ESCs_Mouse0.87450897
97CHD1_26751641_Chip-Seq_LNCaP_Human0.86803739
98FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.86261919
99FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.86187939
100BMI1_23680149_ChIP-Seq_NPCS_Mouse0.85798984
101SUZ12_27294783_Chip-Seq_ESCs_Mouse0.85432110
102MTF2_20144788_ChIP-Seq_MESCs_Mouse0.84149568
103* JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.83040570
104BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.83016684
105CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.82201845
106DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82169109
107CREB1_26743006_Chip-Seq_LNCaP_Human0.81357416
108RXR_22108803_ChIP-Seq_LS180_Human0.81224241
109JARID2_20064375_ChIP-Seq_MESCs_Mouse0.80630215
110* CTCF_27219007_Chip-Seq_Bcells_Human0.79712767
111TP53_20018659_ChIP-ChIP_R1E_Mouse0.78663950
112* AR_21572438_ChIP-Seq_LNCaP_Human0.78037065
113CDX2_22108803_ChIP-Seq_LS180_Human0.77502687
114TBX20_22080862_ChIP-Seq_HEART_Mouse0.76827279
115TBX20_22328084_ChIP-Seq_HEART_Mouse0.76827279
116GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.76377762
117FOXA2_19822575_ChIP-Seq_HepG2_Human0.76239351
118NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.75290904
119NRF2_20460467_ChIP-Seq_MEFs_Mouse0.75290904
120TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.75032128
121PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.74191033
122EZH2_27304074_Chip-Seq_ESCs_Mouse0.74127887
123SMAD4_21741376_ChIP-Seq_HESCs_Human0.73284441
124CEBPB_22108803_ChIP-Seq_LS180_Human0.72890039
125JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.72604463
126RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.72463647
127GATA1_19941826_ChIP-Seq_K562_Human0.71539248
128P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.71180663
129SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.68599586
130UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.65557677
131NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.65513069
132GATA2_19941826_ChIP-Seq_K562_Human0.64643248
133GATA6_21074721_ChIP-Seq_CACO-2_Human0.64033969

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010234_abnormal_vibrissa_follicle9.47698381
2MP0005275_abnormal_skin_tensile5.47354450
3MP0002796_impaired_skin_barrier5.06969493
4MP0008004_abnormal_stomach_pH4.93797536
5MP0000579_abnormal_nail_morphology3.61639714
6MP0010678_abnormal_skin_adnexa3.48719576
7MP0002098_abnormal_vibrissa_morphology3.33820526
8MP0005501_abnormal_skin_physiology3.14080933
9MP0002060_abnormal_skin_morphology2.48119923
10MP0005409_darkened_coat_color2.31815290
11MP0001216_abnormal_epidermal_layer2.27107051
12MP0000377_abnormal_hair_follicle2.21440340
13MP0003705_abnormal_hypodermis_morpholog2.18844061
14MP0003941_abnormal_skin_development2.08061813
15MP0002009_preneoplasia2.05823486
16MP0010771_integument_phenotype2.03286087
17MP0002254_reproductive_system_inflammat2.02735530
18MP0004264_abnormal_extraembryonic_tissu1.98812431
19MP0000383_abnormal_hair_follicle1.94677170
20MP0000647_abnormal_sebaceous_gland1.94533779
21MP0000537_abnormal_urethra_morphology1.94087485
22MP0000467_abnormal_esophagus_morphology1.90706270
23MP0003453_abnormal_keratinocyte_physiol1.86997399
24MP0001873_stomach_inflammation1.75389254
25MP0001664_abnormal_digestion1.72437811
26MP0003566_abnormal_cell_adhesion1.68211361
27MP0004885_abnormal_endolymph1.64979601
28MP0004019_abnormal_vitamin_homeostasis1.63228574
29MP0004381_abnormal_hair_follicle1.62274865
30MP0004947_skin_inflammation1.53478878
31MP0004782_abnormal_surfactant_physiolog1.53335755
32MP0000762_abnormal_tongue_morphology1.52329684
33MP0001765_abnormal_ion_homeostasis1.44590457
34MP0004272_abnormal_basement_membrane1.39681998
35MP0003315_abnormal_perineum_morphology1.37355838
36MP0010386_abnormal_urinary_bladder1.30704472
37MP0000566_synostosis1.26895341
38MP0003300_gastrointestinal_ulcer1.25895899
39MP0002234_abnormal_pharynx_morphology1.25591703
40MP0000538_abnormal_urinary_bladder1.25490711
41MP0001188_hyperpigmentation1.22420447
42MP0000462_abnormal_digestive_system1.21098298
43MP0005636_abnormal_mineral_homeostasis1.18907133
44MP0000470_abnormal_stomach_morphology1.18012458
45MP0003195_calcinosis1.14360388
46MP0000427_abnormal_hair_cycle1.10047863
47MP0001756_abnormal_urination1.09907924
48MP0001849_ear_inflammation1.09539225
49MP0004185_abnormal_adipocyte_glucose1.09164672
50MP0001346_abnormal_lacrimal_gland1.08631567
51MP0009384_cardiac_valve_regurgitation1.07607161
52MP0005310_abnormal_salivary_gland1.07236172
53MP0001666_abnormal_nutrient_absorption1.04965704
54MP0000367_abnormal_coat/_hair1.02744552
55MP0001191_abnormal_skin_condition0.97579408
56MP0006054_spinal_hemorrhage0.95836389
57MP0010352_gastrointestinal_tract_polyps0.93944831
58MP0009931_abnormal_skin_appearance0.92500652
59MP0009379_abnormal_foot_pigmentation0.90522452
60MP0000678_abnormal_parathyroid_gland0.88186447
61MP0000465_gastrointestinal_hemorrhage0.87933261
62MP0004858_abnormal_nervous_system0.87040715
63MP0004043_abnormal_pH_regulation0.84816301
64MP0009643_abnormal_urine_homeostasis0.83396170
65MP0005381_digestive/alimentary_phenotyp0.81793321
66MP0001243_abnormal_dermal_layer0.78259982
67MP0003045_fibrosis0.75650494
68MP0000627_abnormal_mammary_gland0.75606660
69MP0005058_abnormal_lysosome_morphology0.75150012
70MP0002136_abnormal_kidney_physiology0.74950397
71MP0005187_abnormal_penis_morphology0.74575232
72MP0001663_abnormal_digestive_system0.73070763
73MP0002166_altered_tumor_susceptibility0.71652941
74MP0004134_abnormal_chest_morphology0.69789358
75MP0005375_adipose_tissue_phenotype0.69191954
76MP0005666_abnormal_adipose_tissue0.68248619
77MP0002249_abnormal_larynx_morphology0.68142772
78MP0009053_abnormal_anal_canal0.67880475
79MP0002282_abnormal_trachea_morphology0.65779873
80MP0008438_abnormal_cutaneous_collagen0.65463790
81MP0002138_abnormal_hepatobiliary_system0.65057274
82MP0001851_eye_inflammation0.63764347
83MP0002168_other_aberrant_phenotype0.63723411
84MP0002896_abnormal_bone_mineralization0.62781795
85MP0002006_tumorigenesis0.61776517
86MP0008961_abnormal_basal_metabolism0.61319402
87MP0000003_abnormal_adipose_tissue0.60948179
88MP0009780_abnormal_chondrocyte_physiolo0.59845629
89MP0005367_renal/urinary_system_phenotyp0.58526214
90MP0000516_abnormal_urinary_system0.58526214
91MP0001784_abnormal_fluid_regulation0.58167780
92MP0002095_abnormal_skin_pigmentation0.56883312
93MP0000477_abnormal_intestine_morphology0.56266952
94MP0005165_increased_susceptibility_to0.56229396
95MP0003866_abnormal_defecation0.56160824
96MP0003283_abnormal_digestive_organ0.54755559
97MP0003936_abnormal_reproductive_system0.54441798
98MP0003638_abnormal_response/metabolism_0.54299651
99MP0000163_abnormal_cartilage_morphology0.53963033
100MP0003191_abnormal_cellular_cholesterol0.52795411
101MP0002277_abnormal_respiratory_mucosa0.50207061
102MP0008789_abnormal_olfactory_epithelium0.50048404
103MP0001958_emphysema0.49950328
104MP0005508_abnormal_skeleton_morphology0.49147845
105MP0005377_hearing/vestibular/ear_phenot0.48872388
106MP0003878_abnormal_ear_physiology0.48872388
107MP0005076_abnormal_cell_differentiation0.48806346
108MP0005647_abnormal_sex_gland0.46981103
109MP0002233_abnormal_nose_morphology0.46633926
110MP0005248_abnormal_Harderian_gland0.46476915
111MP0005023_abnormal_wound_healing0.46417133
112MP0003011_delayed_dark_adaptation0.46291894
113MP0008875_abnormal_xenobiotic_pharmacok0.45881329
114MP0002876_abnormal_thyroid_physiology0.45035161
115MP0005085_abnormal_gallbladder_physiolo0.44998175
116MP0002111_abnormal_tail_morphology0.41825196
117MP0002653_abnormal_ependyma_morphology0.40272791
118MP0005451_abnormal_body_composition0.39386268
119MP0005645_abnormal_hypothalamus_physiol0.38801068
120MP0010155_abnormal_intestine_physiology0.36699389
121MP0003755_abnormal_palate_morphology0.36633792
122MP0002909_abnormal_adrenal_gland0.35686924
123MP0002139_abnormal_hepatobiliary_system0.33905589
124MP0000432_abnormal_head_morphology0.33618929
125MP0000613_abnormal_salivary_gland0.32394161
126MP0001485_abnormal_pinna_reflex0.31455007
127MP0002177_abnormal_outer_ear0.30010936
128MP0003868_abnormal_feces_composition0.29802272
129MP0008260_abnormal_autophagy0.28636789
130MP0001984_abnormal_olfaction0.28100204
131MP0005394_taste/olfaction_phenotype0.26298572

Predicted human phenotypes

RankGene SetZ-score
1Onycholysis (HP:0001806)7.37894245
2Right ventricular cardiomyopathy (HP:0011663)6.88927406
3Increased IgE level (HP:0003212)6.83083090
4Woolly hair (HP:0002224)5.47267349
5Hypotrichosis (HP:0001006)4.89137904
6Fragile nails (HP:0001808)4.79648204
7Hyperactive renin-angiotensin system (HP:0000841)4.67436644
8Hypokalemic alkalosis (HP:0001949)4.67125334
9Milia (HP:0001056)4.55721453
10Oral leukoplakia (HP:0002745)4.50394954
11Plantar hyperkeratosis (HP:0007556)4.11775346
12Vascular calcification (HP:0004934)4.10879388
13Corneal erosion (HP:0200020)4.03647029
14Abnormality of chloride homeostasis (HP:0011422)4.03518715
15Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.96577039
16Metabolic alkalosis (HP:0200114)3.94362409
17Congenital ichthyosiform erythroderma (HP:0007431)3.91900053
18Cardiovascular calcification (HP:0011915)3.74994689
19Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.60155163
20Acanthosis nigricans (HP:0000956)3.49176401
21Atrophic scars (HP:0001075)3.33400577
22Hyperaldosteronism (HP:0000859)3.24334392
23Palmoplantar keratoderma (HP:0000982)3.23174288
24Pili torti (HP:0003777)3.15757772
25Flat acetabular roof (HP:0003180)3.12066881
26Dehydration (HP:0001944)3.10776496
27Ectropion (HP:0000656)3.10527773
28Absent eyelashes (HP:0000561)3.10448748
29Erythroderma (HP:0001019)3.10336439
30Renal salt wasting (HP:0000127)3.07735336
31Sparse eyelashes (HP:0000653)3.02992447
32Hypohidrosis (HP:0000966)2.98884571
33Absent hair (HP:0002298)2.95077312
34Abnormal respiratory motile cilium physiology (HP:0012261)2.90604170
35Palmoplantar hyperkeratosis (HP:0000972)2.87922638
36Abnormality of the axillary hair (HP:0100134)2.80408106
37Abnormality of secondary sexual hair (HP:0009888)2.80408106
38Nail dystrophy (HP:0008404)2.79158772
39Abnormal respiratory epithelium morphology (HP:0012253)2.78067984
40Abnormal respiratory motile cilium morphology (HP:0005938)2.78067984
41Abnormality of the salivary glands (HP:0010286)2.76551704
42Abnormal ciliary motility (HP:0012262)2.73321724
43Rhinitis (HP:0012384)2.72231632
44Abnormal blistering of the skin (HP:0008066)2.71116826
45Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)2.71032788
46Abnormality of the middle phalanges of the toes (HP:0010183)2.66689906
47Palmar hyperkeratosis (HP:0010765)2.66009043
48Dynein arm defect of respiratory motile cilia (HP:0012255)2.65694862
49Absent/shortened dynein arms (HP:0200106)2.65694862
50Villous atrophy (HP:0011473)2.61298412
51Abnormality of small intestinal villus morphology (HP:0011472)2.61298412
52Sparse scalp hair (HP:0002209)2.60873774
53Alkalosis (HP:0001948)2.59243851
54Abnormality of renin-angiotensin system (HP:0000847)2.54527837
55Abnormality of the 2nd finger (HP:0004100)2.52324068
56Hypoplasia of dental enamel (HP:0006297)2.46117885
57Advanced eruption of teeth (HP:0006288)2.45527132
58Erythema (HP:0010783)2.44562783
59Brittle hair (HP:0002299)2.43298688
60Reticulocytopenia (HP:0001896)2.43186570
61Follicular hyperkeratosis (HP:0007502)2.40672860
62Septate vagina (HP:0001153)2.37676331
63Abnormality of nail color (HP:0100643)2.36977723
64Laryngomalacia (HP:0001601)2.35461747
65Natal tooth (HP:0000695)2.35405935
66Abnormality of the gastric mucosa (HP:0004295)2.31105839
67Gangrene (HP:0100758)2.30364821
68Abnormality of the dental root (HP:0006486)2.30334853
69Taurodontia (HP:0000679)2.30334853
70Abnormality of permanent molar morphology (HP:0011071)2.30334853
71Hypokalemia (HP:0002900)2.29846688
72Amelogenesis imperfecta (HP:0000705)2.27037148
73Abnormality of the labia majora (HP:0012881)2.22692588
74Decreased circulating renin level (HP:0003351)2.20561289
75Parakeratosis (HP:0001036)2.20140689
76Furrowed tongue (HP:0000221)2.20109766
77Amniotic constriction ring (HP:0009775)2.19056648
78Abnormality of placental membranes (HP:0011409)2.19056648
79Hypophosphatemic rickets (HP:0004912)2.17749750
80Alopecia of scalp (HP:0002293)2.17475818
81Synostosis involving the elbow (HP:0003938)2.17205703
82Humeroradial synostosis (HP:0003041)2.17205703
83Potter facies (HP:0002009)2.15811825
84Facial shape deformation (HP:0011334)2.15811825
85Short hallux (HP:0010109)2.15560386
86Choroideremia (HP:0001139)2.15485491
87Conjunctival hamartoma (HP:0100780)2.14414037
88Ventricular tachycardia (HP:0004756)2.13748628
89Abnormality of molar (HP:0011077)2.13458437
90Abnormality of molar morphology (HP:0011070)2.13458437
91Bronchomalacia (HP:0002780)2.13260521
92Abnormality of the phalanges of the 2nd finger (HP:0009541)2.12723921
93Vacuolated lymphocytes (HP:0001922)2.11741315
94Ventricular fibrillation (HP:0001663)2.10067367
95Curly hair (HP:0002212)2.10051408
96Chronic bronchitis (HP:0004469)2.09532572
97Bronchiectasis (HP:0002110)2.08875944
98Hyperphosphatemia (HP:0002905)2.08616653
99Abnormality of the distal phalanx of the thumb (HP:0009617)2.06952353
100Dry hair (HP:0011359)2.05078772
101Abnormality of the dental pulp (HP:0006479)2.04589380
102Pruritus (HP:0000989)2.04479602
103Abnormality of hair growth rate (HP:0011363)2.03552198
104Slow-growing hair (HP:0002217)2.03552198
105Blepharitis (HP:0000498)2.03235489
106Rectal prolapse (HP:0002035)2.02151423
107Thick nail (HP:0001805)2.01042615
108Adrenal overactivity (HP:0002717)2.00122672
109Anonychia (HP:0001798)1.98654833
110Focal segmental glomerulosclerosis (HP:0000097)1.97688611
111Ileus (HP:0002595)1.97341711
112Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.96973463
113Nasal polyposis (HP:0100582)1.95361917
114Hyponatremia (HP:0002902)1.94740001
115Abnormality of potassium homeostasis (HP:0011042)1.94229257
116Selective tooth agenesis (HP:0001592)1.94073461
117Duplicated collecting system (HP:0000081)1.94047218
118Aplasia involving bones of the upper limbs (HP:0009823)1.93247632
119Aplasia of the phalanges of the hand (HP:0009802)1.93247632
120Aplasia involving bones of the extremities (HP:0009825)1.93247632
121Hyperkalemia (HP:0002153)1.93222246
122Symphalangism affecting the phalanges of the hand (HP:0009773)1.93181891
123Complement deficiency (HP:0004431)1.92469049
124Hypoplastic labia majora (HP:0000059)1.89865235
125Tubulointerstitial fibrosis (HP:0005576)1.89827584
126Aplasia/Hypoplasia of the hallux (HP:0008362)1.88771966
12711 pairs of ribs (HP:0000878)1.87794656
128Hypoplasia of the iris (HP:0007676)1.87771659
129Autoamputation (HP:0001218)1.86669416
130Pterygium (HP:0001059)1.86010734
131Abnormality of the distal phalanges of the toes (HP:0010182)1.85911827
132Ridged nail (HP:0001807)1.85909735
133Ureteral obstruction (HP:0006000)1.84898878
134Glomerulosclerosis (HP:0000096)1.84031942
135Hyperhidrosis (HP:0000975)1.82832216
136Abnormality of sodium homeostasis (HP:0010931)1.82535178
137Concave nail (HP:0001598)1.79918226
138Abnormality of renal excretion (HP:0011036)1.79081940
139Popliteal pterygium (HP:0009756)1.78911295
140Lip pit (HP:0100267)1.78540107
141Abnormality of carpal bone ossification (HP:0006257)1.78028539
142Facial diplegia (HP:0001349)1.77482040
143Abnormality of the phalanges of the 5th finger (HP:0004213)1.75327542
144Oligodontia (HP:0000677)1.75101026
145Abnormal hair laboratory examination (HP:0003328)1.74190757
146Pustule (HP:0200039)1.73986375
147Increased circulating renin level (HP:0000848)1.73558313
148Rickets (HP:0002748)1.73422607
149Abnormality of the nasal mucosa (HP:0000433)1.71121099
150Flattened epiphyses (HP:0003071)1.70155647
151Carious teeth (HP:0000670)1.69566720
152Abnormal tarsal ossification (HP:0008369)1.67567708

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MST44.94093209
2CAMK1D4.83377131
3CAMK1G4.12972425
4FRK3.79284357
5FER3.59578149
6LMTK23.56792306
7MST1R3.53366973
8ERBB43.21376394
9WNK42.83321071
10STK392.63109998
11LATS12.60484289
12EPHA22.48842635
13MAP3K22.46697474
14EPHB22.40347227
15MAP3K32.35062453
16MAPK152.24233505
17OXSR12.23830932
18MAPKAPK32.05396958
19BCR2.04372596
20MYLK2.01944655
21TGFBR11.99537374
22ERN11.86679763
23ARAF1.77961017
24LRRK21.70251567
25AKT31.68387366
26PDK21.63427133
27MARK21.62200513
28PTK61.57165374
29PRKD21.50994071
30TRIB31.42621967
31SGK2231.39702335
32SGK4941.39702335
33TRPM71.31011263
34RPS6KB21.24322470
35MET1.24304417
36SMG11.23356056
37TESK11.22987138
38CDK121.21155950
39DMPK1.20822198
40EPHB11.18067152
41PIK3CG1.11103872
42TAOK11.10659993
43RIPK41.10534976
44TAOK31.05716174
45PTK21.04959259
46PRKCI1.03034259
47TTN1.00680565
48ACVR1B1.00639380
49RIPK10.99399897
50EEF2K0.99118321
51TNK20.98142270
52LATS20.96726474
53MAP3K90.96528001
54STK100.93509719
55NUAK10.89497125
56ERBB20.88830914
57PRKAA20.87625328
58GRK10.86709640
59PAK30.81402761
60STK38L0.80703910
61EPHA30.79625361
62MAP2K10.77380598
63MAP2K20.76198961
64MTOR0.75239492
65SGK30.73854571
66SGK20.68335456
67DYRK1B0.68257794
68PKN20.68193310
69DDR20.67844271
70ICK0.65912496
71BMX0.63985929
72ROCK10.62856852
73IRAK10.62547187
74PDGFRA0.62390879
75FGFR20.61006491
76RPS6KA20.60328914
77PRKG20.60212342
78NEK60.59206895
79MAP3K10.58878509
80PIK3CA0.57092809
81MAP3K120.56962298
82FGFR10.56066923
83MAP3K70.55547507
84BCKDK0.55383226
85CDC42BPA0.54143623
86KSR20.53035365
87INSRR0.52984578
88ERBB30.52462955
89IRAK20.50944093
90PRKD30.50762236
91NLK0.50238037
92BRD40.49694025
93MAPKAPK50.48598901
94PAK20.47842763
95RAF10.45987976
96STK240.43775777
97PDK40.43474914
98PDK30.43474914
99PRKAA10.43405903
100SRC0.42227017
101WNK30.41164015
102STK30.40418757
103MAP3K130.40048046
104ROCK20.39137331
105SIK10.39024348
106MAP2K60.38265477
107FGFR40.37795528
108FGFR30.37777240
109FYN0.36962149
110PNCK0.36873256
111CDK60.36849399
112MAPK70.36831517
113IRAK30.36611269
114MAP3K60.36592761
115NME10.36585095
116RPS6KB10.36044088
117MATK0.34302578
118WNK10.33634157
119BRAF0.33484851
120NTRK10.32278712
121EPHA40.31841563
122MAP3K110.31597624
123EGFR0.29184937
124PDGFRB0.28965317
125JAK20.26561175
126STK380.25785043
127SGK10.25693239
128CHUK0.24267178
129PDPK10.23717378
130ILK0.23147150
131PAK40.22738570
132PRKD10.22057564
133MINK10.21952531
134PRKCZ0.21426458
135PRKCE0.21251179
136CAMK10.21081739
137CAMK2G0.20656902
138RET0.20477639
139GSK3A0.19514095
140PIM20.18899365

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur metabolism_Homo sapiens_hsa009203.86717419
2Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005122.56249015
3Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009802.55468392
4Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.53326745
5Mineral absorption_Homo sapiens_hsa049782.39011142
6Chemical carcinogenesis_Homo sapiens_hsa052042.20066881
7Gastric acid secretion_Homo sapiens_hsa049712.07700149
8Collecting duct acid secretion_Homo sapiens_hsa049662.06737416
9Cyanoamino acid metabolism_Homo sapiens_hsa004601.98791721
10ABC transporters_Homo sapiens_hsa020101.96800816
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.95275339
12Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.85584065
13Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.81298968
14Phenylalanine metabolism_Homo sapiens_hsa003601.70742890
15Fatty acid degradation_Homo sapiens_hsa000711.68312516
16Glutathione metabolism_Homo sapiens_hsa004801.65799857
17Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.58168695
18Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.53738656
19Retinol metabolism_Homo sapiens_hsa008301.49129244
20Tight junction_Homo sapiens_hsa045301.41504627
21Salivary secretion_Homo sapiens_hsa049701.40024344
22Histidine metabolism_Homo sapiens_hsa003401.39542399
23ECM-receptor interaction_Homo sapiens_hsa045121.38682669
24Sphingolipid metabolism_Homo sapiens_hsa006001.34336768
25Ovarian steroidogenesis_Homo sapiens_hsa049131.32743109
26Renin-angiotensin system_Homo sapiens_hsa046141.31160450
27Adherens junction_Homo sapiens_hsa045201.29539179
28Linoleic acid metabolism_Homo sapiens_hsa005911.28954235
29beta-Alanine metabolism_Homo sapiens_hsa004101.28949178
30Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.28511355
31PPAR signaling pathway_Homo sapiens_hsa033201.28359134
32Tyrosine metabolism_Homo sapiens_hsa003501.27076909
33Fat digestion and absorption_Homo sapiens_hsa049751.25956278
34Long-term depression_Homo sapiens_hsa047301.25508176
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.19652626
36Arachidonic acid metabolism_Homo sapiens_hsa005901.18679314
37Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.16106567
38Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.15529395
39Basal cell carcinoma_Homo sapiens_hsa052171.15068460
40VEGF signaling pathway_Homo sapiens_hsa043701.14812825
41Nitrogen metabolism_Homo sapiens_hsa009101.14270862
42Pancreatic secretion_Homo sapiens_hsa049721.13211548
43Glycerolipid metabolism_Homo sapiens_hsa005611.12881862
44Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.10855270
45Thyroid hormone synthesis_Homo sapiens_hsa049181.10542827
46Prostate cancer_Homo sapiens_hsa052151.10123534
47Vitamin digestion and absorption_Homo sapiens_hsa049771.09990166
48Other glycan degradation_Homo sapiens_hsa005111.08293381
49Choline metabolism in cancer_Homo sapiens_hsa052311.07499878
50Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.04537649
51Steroid biosynthesis_Homo sapiens_hsa001001.04022400
52Fatty acid metabolism_Homo sapiens_hsa012121.03385449
53Glycerophospholipid metabolism_Homo sapiens_hsa005641.02695842
54Bile secretion_Homo sapiens_hsa049761.00473422
55Leukocyte transendothelial migration_Homo sapiens_hsa046700.96134900
56Caffeine metabolism_Homo sapiens_hsa002320.95040914
57Serotonergic synapse_Homo sapiens_hsa047260.93545704
58Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.92144308
59Protein digestion and absorption_Homo sapiens_hsa049740.90071254
60Hippo signaling pathway_Homo sapiens_hsa043900.88440636
61Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.87179111
62Phosphatidylinositol signaling system_Homo sapiens_hsa040700.84571596
63Bladder cancer_Homo sapiens_hsa052190.83653848
64Circadian rhythm_Homo sapiens_hsa047100.83362516
65Notch signaling pathway_Homo sapiens_hsa043300.83172369
66Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.82688192
67Vibrio cholerae infection_Homo sapiens_hsa051100.82123979
68Butanoate metabolism_Homo sapiens_hsa006500.81159970
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78199715
70Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77978071
71Propanoate metabolism_Homo sapiens_hsa006400.75556204
72Proteoglycans in cancer_Homo sapiens_hsa052050.75161516
73Renin secretion_Homo sapiens_hsa049240.74338884
74Lysosome_Homo sapiens_hsa041420.73900839
75Vascular smooth muscle contraction_Homo sapiens_hsa042700.73072070
76Focal adhesion_Homo sapiens_hsa045100.72991130
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.68377751
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.68328322
79Melanogenesis_Homo sapiens_hsa049160.68252744
80Fatty acid biosynthesis_Homo sapiens_hsa000610.67409492
81Arginine and proline metabolism_Homo sapiens_hsa003300.66806571
82Amoebiasis_Homo sapiens_hsa051460.66012714
83Melanoma_Homo sapiens_hsa052180.65231545
84Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.63919711
85Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63298884
86Arginine biosynthesis_Homo sapiens_hsa002200.62444029
87Hedgehog signaling pathway_Homo sapiens_hsa043400.62320784
88Estrogen signaling pathway_Homo sapiens_hsa049150.62229759
89Tryptophan metabolism_Homo sapiens_hsa003800.61703110
90TGF-beta signaling pathway_Homo sapiens_hsa043500.61116305
91Fatty acid elongation_Homo sapiens_hsa000620.60720275
92Insulin signaling pathway_Homo sapiens_hsa049100.59419661
93Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.59385972
94Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59058662
95Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.58662796
96Small cell lung cancer_Homo sapiens_hsa052220.58597284
97Starch and sucrose metabolism_Homo sapiens_hsa005000.58336615
98Acute myeloid leukemia_Homo sapiens_hsa052210.54651658
99Sphingolipid signaling pathway_Homo sapiens_hsa040710.50477964
100Thyroid cancer_Homo sapiens_hsa052160.50215195
101Glucagon signaling pathway_Homo sapiens_hsa049220.49027174
102Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.48820667
103Insulin resistance_Homo sapiens_hsa049310.47980171
104Inositol phosphate metabolism_Homo sapiens_hsa005620.47635287
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.47611481
106Dorso-ventral axis formation_Homo sapiens_hsa043200.46166348
107Axon guidance_Homo sapiens_hsa043600.44768647
108AMPK signaling pathway_Homo sapiens_hsa041520.43964282
109Platelet activation_Homo sapiens_hsa046110.43864555
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.43022681
111Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.42394483
112Peroxisome_Homo sapiens_hsa041460.42349544
113Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41565377
114MicroRNAs in cancer_Homo sapiens_hsa052060.40505436
115Glioma_Homo sapiens_hsa052140.40102882
116Ether lipid metabolism_Homo sapiens_hsa005650.39256331
117Aldosterone synthesis and secretion_Homo sapiens_hsa049250.38396278
118Rap1 signaling pathway_Homo sapiens_hsa040150.38187727
119Long-term potentiation_Homo sapiens_hsa047200.37968699
120Hepatitis C_Homo sapiens_hsa051600.37799630
121Ras signaling pathway_Homo sapiens_hsa040140.37650943
122Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.37393940
123Pyruvate metabolism_Homo sapiens_hsa006200.36801610
124Endometrial cancer_Homo sapiens_hsa052130.35426474
125Adipocytokine signaling pathway_Homo sapiens_hsa049200.35004507
126Pathways in cancer_Homo sapiens_hsa052000.34148625
127cGMP-PKG signaling pathway_Homo sapiens_hsa040220.34107751
128ErbB signaling pathway_Homo sapiens_hsa040120.32624669
129Regulation of actin cytoskeleton_Homo sapiens_hsa048100.32060996
130Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.30930484
131GnRH signaling pathway_Homo sapiens_hsa049120.30604473
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30271576
133Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29331356
134Toxoplasmosis_Homo sapiens_hsa051450.25243052
135Steroid hormone biosynthesis_Homo sapiens_hsa001400.24877930

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