CX3CR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fractalkine is a transmembrane protein and chemokine involved in the adhesion and migration of leukocytes. The protein encoded by this gene is a receptor for fractalkine. The encoded protein also is a coreceptor for HIV-1, and some variations in this gene lead to increased susceptibility to HIV-1 infection and rapid progression to AIDS. Four transcript variants encoding two different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of chemokine secretion (GO:0090197)9.81858282
2regulation of chemokine secretion (GO:0090196)7.57681273
3G-protein coupled purinergic receptor signaling pathway (GO:0035588)7.33599341
4* microglial cell activation (GO:0001774)7.25448152
5purinergic nucleotide receptor signaling pathway (GO:0035590)7.05683500
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)6.50660742
7regulation of interferon-beta biosynthetic process (GO:0045357)6.29452209
8adenosine receptor signaling pathway (GO:0001973)6.28596564
9antigen processing and presentation of endogenous antigen (GO:0019883)6.26238626
10positive regulation by symbiont of host defense response (GO:0052509)6.08969387
11modulation by symbiont of host defense response (GO:0052031)6.08969387
12modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.08969387
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.08969387
14positive regulation by organism of defense response of other organism involved in symbiotic interact6.08969387
15modulation by symbiont of host immune response (GO:0052553)6.08969387
16positive regulation of gamma-delta T cell activation (GO:0046645)6.02061850
17negative regulation of granulocyte differentiation (GO:0030853)5.90818997
18negative regulation of norepinephrine secretion (GO:0010700)5.85412955
19antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.83470785
20oligosaccharide catabolic process (GO:0009313)5.73463271
21purinergic receptor signaling pathway (GO:0035587)5.55686529
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.50351439
23glycosphingolipid catabolic process (GO:0046479)5.45800017
24chondroitin sulfate catabolic process (GO:0030207)5.34694310
25positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.97561652
26keratan sulfate catabolic process (GO:0042340)4.91514144
27glycolipid catabolic process (GO:0019377)4.89075721
28leukocyte aggregation (GO:0070486)4.84979477
29regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.81470182
30regulation of B cell receptor signaling pathway (GO:0050855)4.80400695
31detection of other organism (GO:0098543)4.49590059
32ceramide catabolic process (GO:0046514)4.49121682
33positive regulation of mast cell activation (GO:0033005)4.36243869
34negative regulation of lymphocyte mediated immunity (GO:0002707)4.35004578
35detection of bacterium (GO:0016045)4.32420287
36monocyte differentiation (GO:0030224)4.31478827
37regulation of gamma-delta T cell activation (GO:0046643)4.31125271
38hyaluronan catabolic process (GO:0030214)4.20857341
39* macrophage activation involved in immune response (GO:0002281)4.18998811
40* macrophage activation (GO:0042116)4.16956668
41response to interleukin-15 (GO:0070672)4.13384188
42cellular response to interleukin-15 (GO:0071350)4.12726489
43antigen processing and presentation via MHC class Ib (GO:0002475)4.10089454
44positive regulation of myeloid leukocyte mediated immunity (GO:0002888)4.04544637
45negative regulation of interleukin-12 production (GO:0032695)3.97288060
46I-kappaB phosphorylation (GO:0007252)3.97084584
47response to host (GO:0075136)3.96689413
48response to host defenses (GO:0052200)3.96689413
49response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.96689413
50detection of external biotic stimulus (GO:0098581)3.95302214
51regulation of gamma-delta T cell differentiation (GO:0045586)3.93980666
52negative regulation of leukocyte mediated immunity (GO:0002704)3.89415755
53response to peptidoglycan (GO:0032494)3.88386270
54immunoglobulin mediated immune response (GO:0016064)3.88342085
55positive regulation of mast cell activation involved in immune response (GO:0033008)3.86238937
56positive regulation of mast cell degranulation (GO:0043306)3.86238937
57detection of molecule of bacterial origin (GO:0032490)3.85633026
58negative thymic T cell selection (GO:0045060)3.85341573
59regulation of myeloid leukocyte mediated immunity (GO:0002886)3.84535700
60negative T cell selection (GO:0043383)3.84062476
61negative regulation of T cell mediated immunity (GO:0002710)3.82700628
62positive regulation of interferon-alpha production (GO:0032727)3.79527001
63neutrophil activation (GO:0042119)3.78407867
64negative regulation of multicellular organism growth (GO:0040015)3.77894616
65regulation of natural killer cell mediated immunity (GO:0002715)3.73791308
66regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.73791308
67lysosome organization (GO:0007040)3.72483311
68lytic vacuole organization (GO:0080171)3.72483311
69response to host immune response (GO:0052572)3.70170776
70response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.70170776
71ruffle organization (GO:0031529)3.68526175
72regulation of macrophage chemotaxis (GO:0010758)3.65109680
73positive T cell selection (GO:0043368)3.63741334
74adaptation of signaling pathway (GO:0023058)3.63575465
75regulation of interferon-alpha production (GO:0032647)3.60669091
76sodium-independent organic anion transport (GO:0043252)3.58163046
77positive thymic T cell selection (GO:0045059)3.57498059
78T cell migration (GO:0072678)3.54986706
79negative regulation of systemic arterial blood pressure (GO:0003085)3.54311931
80negative regulation of tissue remodeling (GO:0034104)3.52319249
81macrophage differentiation (GO:0030225)3.50965492
82negative regulation of catecholamine secretion (GO:0033604)3.50002386
83cyclooxygenase pathway (GO:0019371)3.49632496
84positive regulation of B cell differentiation (GO:0045579)3.49400679
85regulation of hypersensitivity (GO:0002883)3.46901512
86positive regulation of antigen processing and presentation (GO:0002579)3.46860694
87detection of biotic stimulus (GO:0009595)3.46826654
88negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.44385385
89negative regulation of cell killing (GO:0031342)3.44385385
90regulation of T cell mediated cytotoxicity (GO:0001914)3.44115310
91regulation of mast cell activation (GO:0033003)3.43074125
92positive regulation of T cell mediated cytotoxicity (GO:0001916)3.42916035
93positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.42112490
94phagocytosis, engulfment (GO:0006911)3.41383037
95negative regulation of bone resorption (GO:0045779)3.39319653
96T cell selection (GO:0045058)3.39056752
97positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.39036755
98granulocyte activation (GO:0036230)3.37859516
99tolerance induction (GO:0002507)3.37223405
100pathway-restricted SMAD protein phosphorylation (GO:0060389)3.36879194
101cell-cell junction maintenance (GO:0045217)3.35523236
102negative regulation of interleukin-6 production (GO:0032715)3.35414220
103negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.33756563
104positive regulation of B cell mediated immunity (GO:0002714)3.31520554
105positive regulation of immunoglobulin mediated immune response (GO:0002891)3.31520554
106ganglioside metabolic process (GO:0001573)3.30969885
107leukocyte migration involved in inflammatory response (GO:0002523)3.29471425
108mannose metabolic process (GO:0006013)3.29439254
109negative regulation of phagocytosis (GO:0050765)3.26214526
110leukocyte degranulation (GO:0043299)3.23681939
111response to cholesterol (GO:0070723)3.23349592
112regulation of leukocyte degranulation (GO:0043300)3.21895468
113positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.21053457
114regulation of alpha-beta T cell proliferation (GO:0046640)3.18609731
115positive regulation of isotype switching (GO:0045830)3.18054432
116cellular extravasation (GO:0045123)3.17115030
117regulation of tolerance induction (GO:0002643)3.14340827
118response to type I interferon (GO:0034340)3.14065047
119glial cell migration (GO:0008347)3.13842272
120type I interferon signaling pathway (GO:0060337)3.13747700
121cellular response to type I interferon (GO:0071357)3.13747700
122myeloid leukocyte mediated immunity (GO:0002444)3.12239548
123T-helper 1 type immune response (GO:0042088)3.10745667
124mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.09596367
125positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.09435570
126mast cell activation (GO:0045576)3.07746574
127germ cell migration (GO:0008354)3.05376617
128phosphatidylglycerol biosynthetic process (GO:0006655)3.05235034
129negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.04228135
130interferon-gamma production (GO:0032609)3.03787561
131interferon-gamma-mediated signaling pathway (GO:0060333)3.02685255
132positive regulation of smooth muscle cell migration (GO:0014911)3.02601696
133regulation of leukocyte mediated cytotoxicity (GO:0001910)3.01960187
134negative regulation of B cell proliferation (GO:0030889)3.01342632
135B cell mediated immunity (GO:0019724)3.01316329
136histone H4-K12 acetylation (GO:0043983)3.00589176
137regulation of isotype switching to IgG isotypes (GO:0048302)3.00144048
138thymic T cell selection (GO:0045061)2.99586391
139regulation of monocyte differentiation (GO:0045655)2.96247624
140neutrophil mediated immunity (GO:0002446)2.93638086
141production of molecular mediator involved in inflammatory response (GO:0002532)2.93192189
142regulation of monocyte chemotaxis (GO:0090025)2.88582767
143histamine secretion (GO:0001821)2.86214089
144regulation of granulocyte differentiation (GO:0030852)2.84833752
145negative regulation of smooth muscle contraction (GO:0045986)2.84315329
146regulation of chemokine-mediated signaling pathway (GO:0070099)2.83135731
147regulation of T cell tolerance induction (GO:0002664)2.83023766
148Rac protein signal transduction (GO:0016601)2.79123054
149regulation of antigen processing and presentation (GO:0002577)2.78179317
150regulation of mast cell degranulation (GO:0043304)2.75315298
151neutrophil activation involved in immune response (GO:0002283)2.74254335
152response to laminar fluid shear stress (GO:0034616)2.71816541
153regulation of mast cell activation involved in immune response (GO:0033006)2.71569882
154sphingolipid catabolic process (GO:0030149)2.71286316
155positive regulation of chemokine production (GO:0032722)2.70820703
156response to muramyl dipeptide (GO:0032495)2.70529983
157* myeloid cell activation involved in immune response (GO:0002275)2.70390307
158regulation of norepinephrine secretion (GO:0014061)2.68398900
159response to sterol (GO:0036314)2.67870876
160negative regulation of bone remodeling (GO:0046851)2.67595227
161regulation of actin cytoskeleton reorganization (GO:2000249)2.65682495
162B cell receptor signaling pathway (GO:0050853)2.65356187
163negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.65202571
164activated T cell proliferation (GO:0050798)2.62201971
165regulation of B cell differentiation (GO:0045577)2.62199076
166respiratory burst (GO:0045730)2.61703239
167regulation of platelet aggregation (GO:0090330)2.61288821
168regulation of bone resorption (GO:0045124)2.60322645
169G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)11.1886916

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1BP1_19119308_ChIP-ChIP_Hs578T_Human5.01103183
2IRF8_21731497_ChIP-ChIP_J774_Mouse4.81473564
3* IRF8_27001747_Chip-Seq_BMDM_Mouse4.24668179
4* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.77744935
5SCL_19346495_ChIP-Seq_HPC-7_Human3.18178892
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.09830516
7IRF8_22096565_ChIP-ChIP_GC-B_Human2.89777168
8VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.75789419
9NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.70333769
10NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.70115551
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.48437470
12MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.37444345
13STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.37297750
14RUNX_20019798_ChIP-Seq_JUKART_Human2.34850959
15SPI1_23127762_ChIP-Seq_K562_Human2.31784361
16Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.21410092
17* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.18548015
18NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.17036539
19UTX_26944678_Chip-Seq_JUKART_Human2.12594263
20CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.11938396
21IKZF1_21737484_ChIP-ChIP_HCT116_Human1.98504200
22SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.91996798
23VDR_24787735_ChIP-Seq_THP-1_Human1.91183554
24CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.83001495
25* GATA3_27048872_Chip-Seq_THYMUS_Human1.81953103
26GATA1_22025678_ChIP-Seq_K562_Human1.71245088
27MYC_22102868_ChIP-Seq_BL_Human1.70735962
28PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.65216363
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62552901
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.59581463
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.58388819
32ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56129656
33MAF_26560356_Chip-Seq_TH2_Human1.55252179
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.54253635
35KDM2B_26808549_Chip-Seq_DND41_Human1.52145375
36BRD4_27068464_Chip-Seq_AML-cells_Mouse1.50868960
37WT1_19549856_ChIP-ChIP_CCG9911_Human1.50176078
38VDR_24763502_ChIP-Seq_THP-1_Human1.49442788
39VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.48726012
40KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.45623996
41KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.41562113
42FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.41334315
43SPI1_23547873_ChIP-Seq_NB4_Human1.40795219
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.39864593
45IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39838572
46* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.39042527
47KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.35916973
48KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.35916973
49KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.35916973
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.32379535
51CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.32019673
52PU_27001747_Chip-Seq_BMDM_Mouse1.30126113
53DROSHA_22980978_ChIP-Seq_HELA_Human1.29865407
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.29636189
55SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27445442
56* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.26450379
57FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.24200858
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23818648
59SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.22755310
60* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.21440523
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.19693923
62RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.19643376
63GBX2_23144817_ChIP-Seq_PC3_Human1.19539240
64* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.19055557
65GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.18906105
66TCF7_22412390_ChIP-Seq_EML_Mouse1.18381687
67* NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.17847107
68GATA2_19941826_ChIP-Seq_K562_Human1.15745133
69KDM2B_26808549_Chip-Seq_JURKAT_Human1.15676846
70PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.14891024
71ESR2_21235772_ChIP-Seq_MCF-7_Human1.13508776
72BCL6_27268052_Chip-Seq_Bcells_Human1.13047010
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.12881876
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.12122994
75CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.10366394
76TP53_16413492_ChIP-PET_HCT116_Human1.09299946
77* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08044433
78KDM2B_26808549_Chip-Seq_SUP-B15_Human1.07901115
79LXR_22292898_ChIP-Seq_THP-1_Human1.07801165
80GATA2_22383799_ChIP-Seq_G1ME_Mouse1.07343323
81SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.04610396
82GATA1_19941826_ChIP-Seq_K562_Human1.04453421
83RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.04115894
84SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03311954
85* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.03229943
86SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.02826487
87ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00401607
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00227475
89ZNF217_24962896_ChIP-Seq_MCF-7_Human1.00080939
90EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99552092
91GATA2_21666600_ChIP-Seq_HMVEC_Human0.97640271
92ARNT_22903824_ChIP-Seq_MCF-7_Human0.97082277
93VDR_21846776_ChIP-Seq_THP-1_Human0.96003559
94CDX2_20551321_ChIP-Seq_CACO-2_Human0.95994063
95ELK3_25401928_ChIP-Seq_HUVEC_Human0.95112741
96CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.94769150
97MYB_26560356_Chip-Seq_TH2_Human0.94604992
98SMAD3_21741376_ChIP-Seq_HESCs_Human0.94158883
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.94107007
100* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93287332
101GATA1_19941827_ChIP-Seq_MEL_Mouse0.91825636
102SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.87243208
103PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.87095214
104MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.86535229
105GATA1_19941827_ChIP-Seq_MEL86_Mouse0.86468812
106BCOR_27268052_Chip-Seq_Bcells_Human0.86162979
107ELF1_20517297_ChIP-Seq_JURKAT_Human0.84930766
108* PU.1_20513432_ChIP-Seq_Bcells_Mouse0.84783375
109TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.84739956
110SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.84114811
111* SMRT_27268052_Chip-Seq_Bcells_Human0.83760938
112* RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.83147865
113MAF_26560356_Chip-Seq_TH1_Human0.82809584
114SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.81600922
115SPI1_20517297_ChIP-Seq_HL60_Human0.81472743
116AHR_22903824_ChIP-Seq_MCF-7_Human0.80436080
117EZH2_18974828_ChIP-Seq_MESCs_Mouse0.79724687
118RNF2_18974828_ChIP-Seq_MESCs_Mouse0.79724687
119PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.79633718
120RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.79089130
121CTCF_27219007_Chip-Seq_ERYTHROID_Human0.78627142
122* SA1_27219007_Chip-Seq_ERYTHROID_Human0.78546426
123WT1_25993318_ChIP-Seq_PODOCYTE_Human0.77980474
124CJUN_26792858_Chip-Seq_BT549_Human0.77977666
125* RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.77521919
126CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76753333
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.76595790
128SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.76356507
129CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.75670841
130ZFP57_27257070_Chip-Seq_ESCs_Mouse0.75619559
131MYB_26560356_Chip-Seq_TH1_Human0.75612793
132TCF4_22108803_ChIP-Seq_LS180_Human0.75022388
133ESR1_21235772_ChIP-Seq_MCF-7_Human0.74262480
134STAT4_19710469_ChIP-ChIP_TH1__Mouse0.74048267
135TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.73932278
136GATA3_26560356_Chip-Seq_TH2_Human0.72541084
137EGR1_19032775_ChIP-ChIP_M12_Human0.72395312
138VDR_22108803_ChIP-Seq_LS180_Human0.71971629
139* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.71853481
140MTF2_20144788_ChIP-Seq_MESCs_Mouse0.71581110
141* NR3C1_23031785_ChIP-Seq_PC12_Mouse0.70068228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003191_abnormal_cellular_cholesterol6.62971109
2MP0005058_abnormal_lysosome_morphology5.35704333
3MP0003172_abnormal_lysosome_physiology4.57319147
4* MP0006082_CNS_inflammation3.71653144
5MP0001835_abnormal_antigen_presentation3.64679962
6MP0005464_abnormal_platelet_physiology3.51558359
7MP0003303_peritoneal_inflammation3.15858910
8MP0003075_altered_response_to2.88150603
9MP0003763_abnormal_thymus_physiology2.85199441
10MP0008004_abnormal_stomach_pH2.67609899
11* MP0009785_altered_susceptibility_to2.54372343
12* MP0002419_abnormal_innate_immunity2.52379268
13MP0002132_abnormal_respiratory_system2.49061685
14* MP0003690_abnormal_glial_cell2.36557279
15MP0002148_abnormal_hypersensitivity_rea2.35529553
16MP0003183_abnormal_peptide_metabolism2.32833282
17MP0008260_abnormal_autophagy2.32059597
18* MP0005671_abnormal_response_to2.25074876
19MP0003045_fibrosis2.16031203
20MP0001851_eye_inflammation2.15070543
21* MP0002452_abnormal_antigen_presenting2.11532252
22MP0009840_abnormal_foam_cell2.09960948
23MP0002723_abnormal_immune_serum2.02018506
24MP0003252_abnormal_bile_duct1.99185352
25MP0005670_abnormal_white_adipose1.89025622
26MP0001800_abnormal_humoral_immune1.87989658
27MP0003436_decreased_susceptibility_to1.84541610
28MP0000343_altered_response_to1.82682660
29* MP0005000_abnormal_immune_tolerance1.82557566
30MP0001533_abnormal_skeleton_physiology1.82093542
31MP0003724_increased_susceptibility_to1.77526232
32MP0000858_altered_metastatic_potential1.76045088
33MP0003866_abnormal_defecation1.71608854
34MP0002090_abnormal_vision1.71496000
35* MP0001819_abnormal_immune_cell1.70679939
36MP0005167_abnormal_blood-brain_barrier1.65471967
37* MP0002420_abnormal_adaptive_immunity1.65390911
38MP0003300_gastrointestinal_ulcer1.64338888
39MP0002928_abnormal_bile_duct1.63381975
40MP0000703_abnormal_thymus_morphology1.61461464
41MP0002998_abnormal_bone_remodeling1.57766790
42MP0000465_gastrointestinal_hemorrhage1.55853248
43* MP0009333_abnormal_splenocyte_physiolog1.47195410
44MP0008469_abnormal_protein_level1.43255973
45MP0004381_abnormal_hair_follicle1.37018872
46MP0009384_cardiac_valve_regurgitation1.35063558
47MP0005310_abnormal_salivary_gland1.34059777
48* MP0005025_abnormal_response_to1.32684146
49MP0002396_abnormal_hematopoietic_system1.32018644
50MP0002254_reproductive_system_inflammat1.29382690
51MP0001845_abnormal_inflammatory_respons1.29169082
52MP0004510_myositis1.28500429
53MP0004185_abnormal_adipocyte_glucose1.24027347
54MP0001986_abnormal_taste_sensitivity1.23753015
55MP0003633_abnormal_nervous_system1.20956643
56MP0000767_abnormal_smooth_muscle1.20132886
57MP0003279_aneurysm1.19681864
58MP0003828_pulmonary_edema1.18689776
59* MP0000716_abnormal_immune_system1.18130147
60MP0000689_abnormal_spleen_morphology1.17860048
61MP0008007_abnormal_cellular_replicative1.17856786
62MP0002405_respiratory_system_inflammati1.15564170
63MP0008874_decreased_physiological_sensi1.13493057
64MP0005165_increased_susceptibility_to1.10084163
65MP0004145_abnormal_muscle_electrophysio1.07602661
66MP0002736_abnormal_nociception_after1.07093353
67MP0003448_altered_tumor_morphology1.05596658
68MP0009764_decreased_sensitivity_to1.04434918
69MP0001663_abnormal_digestive_system1.03525144
70MP0001790_abnormal_immune_system1.01417335
71MP0005387_immune_system_phenotype1.01417335
72MP0001542_abnormal_bone_strength1.01375556
73MP0002398_abnormal_bone_marrow1.00880061
74MP0005085_abnormal_gallbladder_physiolo0.99969259
75* MP0000920_abnormal_myelination0.99662433
76* MP0000249_abnormal_blood_vessel0.97860160
77MP0002722_abnormal_immune_system0.97469229
78MP0001545_abnormal_hematopoietic_system0.96785237
79MP0005397_hematopoietic_system_phenotyp0.96785237
80* MP0005166_decreased_susceptibility_to0.96112496
81* MP0005164_abnormal_response_to0.95994727
82MP0002064_seizures0.93830675
83MP0005409_darkened_coat_color0.91939970
84MP0004130_abnormal_muscle_cell0.90340502
85MP0001853_heart_inflammation0.90247823
86* MP0002429_abnormal_blood_cell0.89298649
87* MP0009763_increased_sensitivity_to0.85520909
88MP0005666_abnormal_adipose_tissue0.84590007
89MP0005451_abnormal_body_composition0.79920860
90MP0005390_skeleton_phenotype0.78677883
91MP0003566_abnormal_cell_adhesion0.77804037
92* MP0003634_abnormal_glial_cell0.76640593
93MP0005023_abnormal_wound_healing0.75578971
94MP0002933_joint_inflammation0.74889351
95MP0004484_altered_response_of0.74229522
96MP0000685_abnormal_immune_system0.73201185
97MP0005647_abnormal_sex_gland0.72879777
98MP0003795_abnormal_bone_structure0.72345538
99MP0001873_stomach_inflammation0.72313172
100MP0005075_abnormal_melanosome_morpholog0.71815792
101MP0009278_abnormal_bone_marrow0.71212963
102MP0002006_tumorigenesis0.70221697
103MP0010155_abnormal_intestine_physiology0.66070578
104MP0001348_abnormal_lacrimal_gland0.65985028
105MP0001968_abnormal_touch/_nociception0.64449672
106MP0005535_abnormal_body_temperature0.64323065
107MP0003631_nervous_system_phenotype0.62958637
108MP0002557_abnormal_social/conspecific_i0.61386328
109MP0001963_abnormal_hearing_physiology0.60863863
110MP0000604_amyloidosis0.60086889
111MP0005381_digestive/alimentary_phenotyp0.59720734
112MP0009765_abnormal_xenobiotic_induced0.59042773
113MP0002277_abnormal_respiratory_mucosa0.58404640
114MP0000015_abnormal_ear_pigmentation0.57393141
115* MP0008873_increased_physiological_sensi0.57195394
116MP0003638_abnormal_response/metabolism_0.56914412
117* MP0004883_abnormal_blood_vessel0.56345685
118MP0005083_abnormal_biliary_tract0.56189739
119MP0002693_abnormal_pancreas_physiology0.56086420
120MP0002166_altered_tumor_susceptibility0.55968134
121MP0002135_abnormal_kidney_morphology0.54505651
122MP0004859_abnormal_synaptic_plasticity0.53566686
123MP0009053_abnormal_anal_canal0.53165336
124MP0004808_abnormal_hematopoietic_stem0.52102067
125MP0002019_abnormal_tumor_incidence0.51461167
126MP0004947_skin_inflammation0.50255690
127MP0002136_abnormal_kidney_physiology0.49344116
128MP0000490_abnormal_crypts_of0.49033027
129MP0000569_abnormal_digit_pigmentation0.48733689
130MP0003879_abnormal_hair_cell0.48396014
131MP0005388_respiratory_system_phenotype0.44479638
132MP0002133_abnormal_respiratory_system0.44479638
133MP0003091_abnormal_cell_migration0.44152931
134MP0001765_abnormal_ion_homeostasis0.43085905
135MP0003787_abnormal_imprinting0.42664449

Predicted human phenotypes

RankGene SetZ-score
1Systemic lupus erythematosus (HP:0002725)9.47615364
2Glomerulonephritis (HP:0000099)8.44744463
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.53108368
4Abnormality of glycolipid metabolism (HP:0010969)7.53108368
5Abnormality of liposaccharide metabolism (HP:0010968)7.53108368
6Complement deficiency (HP:0004431)6.43538588
7Arterial tortuosity (HP:0005116)5.95090838
8Mutism (HP:0002300)5.35101604
9Vascular tortuosity (HP:0004948)5.20487465
10Urethral obstruction (HP:0000796)5.04651722
11Recurrent fungal infections (HP:0002841)4.76855513
12Orchitis (HP:0100796)4.73762854
13Retinal atrophy (HP:0001105)4.73367614
14Dysostosis multiplex (HP:0000943)4.63790260
15Cerebral aneurysm (HP:0004944)4.63426313
16Abnormality of complement system (HP:0005339)4.60350098
17Chronic mucocutaneous candidiasis (HP:0002728)4.53543065
18Recurrent cutaneous fungal infections (HP:0011370)4.53543065
19Optic neuritis (HP:0100653)4.51256217
20Retrobulbar optic neuritis (HP:0100654)4.51256217
21Increased cerebral lipofuscin (HP:0011813)4.50743528
22Increased neuronal autofluorescent lipopigment (HP:0002074)4.44247976
23Stomatitis (HP:0010280)4.43345486
24Abnormal delayed hypersensitivity skin test (HP:0002963)4.24810792
25Abnormality of T cell number (HP:0011839)4.15725946
26Nephritis (HP:0000123)4.11811689
27Recurrent abscess formation (HP:0002722)4.10901100
28T lymphocytopenia (HP:0005403)4.10101416
29Recurrent bacterial skin infections (HP:0005406)3.99689234
30Meningitis (HP:0001287)3.90930202
31Encephalitis (HP:0002383)3.87344445
32Orthostatic hypotension (HP:0001278)3.83254009
33Chronic diarrhea (HP:0002028)3.81255408
34Aortic aneurysm (HP:0004942)3.79810964
35Gastrointestinal infarctions (HP:0005244)3.77058644
36Mediastinal lymphadenopathy (HP:0100721)3.71826821
37Hematochezia (HP:0002573)3.71159232
38Keratoconjunctivitis (HP:0001096)3.61914911
39Axonal loss (HP:0003447)3.55912261
40Disinhibition (HP:0000734)3.51292344
41Increased IgE level (HP:0003212)3.45845601
42Progressive neurologic deterioration (HP:0002344)3.45781355
43Agnosia (HP:0010524)3.37469383
44Vasculitis (HP:0002633)3.36829216
45Leukocytosis (HP:0001974)3.33971881
46Abnormality of T cells (HP:0002843)3.28091283
47Eczematoid dermatitis (HP:0000976)3.27304890
48Pustule (HP:0200039)3.25994313
49Abnormal platelet function (HP:0011869)3.24243895
50Impaired platelet aggregation (HP:0003540)3.24243895
51Keratoconjunctivitis sicca (HP:0001097)3.23211788
52Hemiplegia (HP:0002301)3.21095727
53Gingivitis (HP:0000230)3.21002411
54Mucopolysacchariduria (HP:0008155)3.19583896
55Urinary glycosaminoglycan excretion (HP:0003541)3.19583896
56Disproportionate tall stature (HP:0001519)3.18975532
57Recurrent viral infections (HP:0004429)3.13898059
58Vacuolated lymphocytes (HP:0001922)3.09739830
59Hepatosplenomegaly (HP:0001433)3.09269584
60Partial duplication of thumb phalanx (HP:0009944)3.06323371
61Intestinal atresia (HP:0011100)3.04644697
62Chest pain (HP:0100749)3.04592446
63Neuronal loss in central nervous system (HP:0002529)3.04406998
64Abnormality of mucopolysaccharide metabolism (HP:0011020)3.03151557
65Abnormality of polysaccharide metabolism (HP:0011012)3.03151557
66Abnormality of glycosaminoglycan metabolism (HP:0004371)3.03151557
67Colitis (HP:0002583)3.02635277
68Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)3.01794620
69Granulocytopenia (HP:0001913)2.98417505
70Striae distensae (HP:0001065)2.97199351
71Upper motor neuron abnormality (HP:0002127)2.95841451
72Increased IgM level (HP:0003496)2.93812113
73Eosinophilia (HP:0001880)2.93802015
74Gingival bleeding (HP:0000225)2.93357968
75Spondylolisthesis (HP:0003302)2.91908739
76Aortic dissection (HP:0002647)2.91092799
77Panhypogammaglobulinemia (HP:0003139)2.90528940
78Urticaria (HP:0001025)2.88288223
79Rectal fistula (HP:0100590)2.86121271
80Rectovaginal fistula (HP:0000143)2.86121271
81Split foot (HP:0001839)2.85001463
82Hemoptysis (HP:0002105)2.81454687
83Intestinal fistula (HP:0100819)2.78459156
84Hypochromic anemia (HP:0001931)2.78247444
85Nasal polyposis (HP:0100582)2.78029387
86Cellulitis (HP:0100658)2.76938789
87Pulmonary infiltrates (HP:0002113)2.76359107
88Agammaglobulinemia (HP:0004432)2.65831832
89Episodic fever (HP:0001954)2.62396852
90Partial duplication of the phalanx of hand (HP:0009999)2.61170799
91Lymphopenia (HP:0001888)2.60127358
92Arterial thrombosis (HP:0004420)2.58907384
93Autoimmune hemolytic anemia (HP:0001890)2.57355885
94Hypochromic microcytic anemia (HP:0004840)2.56975167
95Abnormality of T cell physiology (HP:0011840)2.56549355
96Anorexia (HP:0002039)2.56515601
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.55509765
98Abnormality of eosinophils (HP:0001879)2.50469013
99Osteomyelitis (HP:0002754)2.50401101
100Arnold-Chiari malformation (HP:0002308)2.49674929
101J-shaped sella turcica (HP:0002680)2.48483896
102Vaginal fistula (HP:0004320)2.46312508
103Hypergammaglobulinemia (HP:0010702)2.45440596
104Peritonitis (HP:0002586)2.44630498
105Cardiomegaly (HP:0001640)2.41707732
106Inflammation of the large intestine (HP:0002037)2.40568858
107Pulmonary embolism (HP:0002204)2.40087517
108Autoimmune thrombocytopenia (HP:0001973)2.36013552
109Amyloidosis (HP:0011034)2.35123501
110Purpura (HP:0000979)2.32482957
111Pathologic fracture (HP:0002756)2.30359781
112Papilledema (HP:0001085)2.28618447
113Abnormality of the nasal mucosa (HP:0000433)2.27701802
114Lower limb asymmetry (HP:0100559)2.26205424
115Recurrent skin infections (HP:0001581)2.24189958
116Inappropriate behavior (HP:0000719)2.17764116
117Vertigo (HP:0002321)2.17067473
118Thoracic kyphosis (HP:0002942)2.15059795
119Gastrointestinal inflammation (HP:0004386)2.15048935
120Recurrent bronchitis (HP:0002837)2.14513700
121Recurrent gram-negative bacterial infections (HP:0005420)2.08461773
122Sepsis (HP:0100806)2.05590166
123Postural instability (HP:0002172)2.04379454
124Keratitis (HP:0000491)2.04017765
125Exotropia (HP:0000577)2.03876119
126Basal ganglia calcification (HP:0002135)2.03275908
127Urinary incontinence (HP:0000020)2.01429363
128Mitral valve prolapse (HP:0001634)2.01244826
129Abnormality of the pleura (HP:0002103)2.01061870
130IgM deficiency (HP:0002850)2.00552197
131Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.99749315
132Joint swelling (HP:0001386)1.99482170
133Petechiae (HP:0000967)1.99347843
134Gangrene (HP:0100758)1.99013465
135Increased serum ferritin (HP:0003281)1.98214482
136Cheilitis (HP:0100825)1.97858767
137Dementia (HP:0000726)1.95620638
138Obstructive sleep apnea (HP:0002870)1.94226662
139Erectile abnormalities (HP:0100639)1.90613445
140Stomach cancer (HP:0012126)1.89169665
141Thick nail (HP:0001805)1.88921671
142Increased CSF protein (HP:0002922)1.88435616
143Abnormality of iron homeostasis (HP:0011031)1.88189124
144Thickened calvaria (HP:0002684)1.87684296
145Myositis (HP:0100614)1.86922087
146Microcytic anemia (HP:0001935)1.86564755
147Lymphoma (HP:0002665)1.86392717
148Verrucae (HP:0200043)1.86041725
149Papilloma (HP:0012740)1.86041725
150Abnormality of macrophages (HP:0004311)1.85997062
151Skin ulcer (HP:0200042)1.85050718
152Abnormality of the endocardium (HP:0004306)1.84375786
153Abnormality of the pericardium (HP:0001697)1.83402993
154Abnormality of the peritoneum (HP:0002585)1.82279765
155Slow saccadic eye movements (HP:0000514)1.82203994
156Polygenic inheritance (HP:0010982)1.80269218
157Progressive visual loss (HP:0000529)1.78699035
158Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.78418079
159Epistaxis (HP:0000421)1.77783808
160Elevated erythrocyte sedimentation rate (HP:0003565)1.76310365
161Macroglossia (HP:0000158)1.74213284
162Prolonged bleeding time (HP:0003010)1.73611054
163Peripheral demyelination (HP:0011096)1.73154737
164Camptodactyly of toe (HP:0001836)1.69471177
165Abnormal autonomic nervous system physiology (HP:0012332)1.69093094
166Joint stiffness (HP:0001387)1.67079301
167Spontaneous hematomas (HP:0007420)1.66378318
168Clumsiness (HP:0002312)1.65143709
169Bone pain (HP:0002653)1.63182495
170Anal stenosis (HP:0002025)1.59366946
171Apathy (HP:0000741)1.55959908
172Periauricular skin pits (HP:0100277)1.53320825
173Preauricular pit (HP:0004467)1.53320825
174Flared iliac wings (HP:0002869)1.52972769
175Bicuspid aortic valve (HP:0001647)1.52772901
176Chronic obstructive pulmonary disease (HP:0006510)1.49835051
177Obstructive lung disease (HP:0006536)1.49835051
178Gastrointestinal atresia (HP:0002589)1.49225215

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TGFBR28.71924356
2MAPK155.21598889
3GRK74.64261810
4CSF1R3.58816007
5PDK23.36316610
6BLK2.76834407
7TSSK62.44529260
8TYK22.27970333
9RIPK42.26244236
10TNK21.92530394
11PRPF4B1.88383400
12NEK91.77226456
13MAPK121.75063333
14GRK61.74732287
15CAMK1D1.68128583
16JAK31.67987283
17STK101.64370205
18MATK1.60081865
19PAK41.59801446
20MOS1.55937003
21MAPK71.51207429
22TAOK31.50627338
23CLK11.48019419
24IRAK41.42526370
25CAMK1G1.37167516
26TXK1.33542507
27JAK11.32340347
28AKT31.29738078
29VRK11.29121641
30MAP3K111.27933692
31NEK61.26129557
32GRK51.21394724
33MAP3K31.17085687
34ADRBK21.16494981
35FES1.16273091
36TBK11.16207467
37PASK1.15796940
38TEC1.13924667
39PRKD21.12101009
40MAP4K11.10571330
41CDK31.08841022
42HCK1.04585900
43ERN11.04547667
44IRAK31.03150168
45ZAP701.01510043
46TAOK11.01028425
47CSK1.00755027
48SGK20.96708888
49KIT0.96652976
50PDK10.96293009
51PAK20.94594864
52MAP3K90.94362500
53ITK0.94349701
54SGK30.92186546
55LYN0.90280000
56MAP3K70.89539192
57CDK80.86262927
58PIM10.85886670
59TESK20.85104316
60CAMKK20.83148192
61PTK2B0.82703815
62MAP3K10.81674228
63LRRK20.80785232
64CAMKK10.79081962
65KSR20.78549982
66IKBKB0.78534713
67PRKCH0.78486878
68JAK20.78289015
69KSR10.76519306
70SIK20.76263765
71LCK0.74526398
72MAP3K130.73460138
73HIPK20.72089398
74MARK20.71053961
75PDPK10.69306697
76PRKCQ0.69054995
77MAPKAPK50.68502282
78CAMK40.64999495
79EPHB10.64699082
80MAP3K140.61411591
81IGF1R0.60277196
82PIK3CG0.59737919
83SYK0.58955281
84FGFR30.56665450
85MAPKAPK20.55090089
86TAF10.54779047
87MAP3K20.53309571
88MAP2K30.52698194
89EIF2AK20.52607626
90SIK30.52171835
91PKN10.51975903
92NLK0.51229880
93MAP2K40.49795149
94SGK4940.49602738
95SGK2230.49602738
96IRAK10.48283006
97CDK190.48275780
98EEF2K0.46189956
99PKN20.46153446
100RIPK10.43598156
101CDK60.43585724
102CDK40.42894986
103FGFR40.42725083
104PRKAA20.42573512
105MELK0.41693045
106FGR0.41421247
107ARAF0.41135981
108CDC42BPA0.39691238
109MAP2K60.39513092
110STK110.39465964
111INSR0.39013079
112CDK90.38351693
113STK380.37296920
114RET0.37194111
115EPHA30.36963607
116YES10.36008134
117RPS6KA20.34749627
118GSK3A0.34543136
119DYRK1B0.31649843
120ILK0.31635382
121BMPR20.30876421
122TRIB30.30787345
123PTK60.30213103
124PRKD10.30210396
125MAPK40.30151836
126PRKCZ0.30148674
127BRAF0.29715640
128PRKG10.28810936
129IKBKE0.27466403
130EGFR0.27133537
131KDR0.27116373
132BTK0.27066385
133MARK30.23961139
134IRAK20.23572795
135BMPR1B0.23017929
136CAMK10.22813663
137MAP2K20.22021568
138FYN0.20564831
139DMPK0.20385155
140RPS6KA60.19116791
141TRPM70.18410986
142MAP3K60.18293659
143RPS6KC10.17953989
144RPS6KL10.17953989
145RPS6KA40.16382870
146MAPKAPK30.16123708
147ICK0.15414254
148PRKCD0.15279563
149INSRR0.14628152
150ABL10.14174428

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.69257609
2Glycosaminoglycan degradation_Homo sapiens_hsa005314.67896108
3Other glycan degradation_Homo sapiens_hsa005114.54343019
4Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006034.34014858
5Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.92024977
6Lysosome_Homo sapiens_hsa041422.87897539
7Allograft rejection_Homo sapiens_hsa053302.59955775
8Osteoclast differentiation_Homo sapiens_hsa043802.55700126
9Autoimmune thyroid disease_Homo sapiens_hsa053202.49692885
10Primary immunodeficiency_Homo sapiens_hsa053402.47222875
11Prion diseases_Homo sapiens_hsa050202.17991731
12Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051422.07422951
13B cell receptor signaling pathway_Homo sapiens_hsa046622.02161243
14Type I diabetes mellitus_Homo sapiens_hsa049401.98563755
15Leishmaniasis_Homo sapiens_hsa051401.86756053
16Pertussis_Homo sapiens_hsa051331.85096638
17Viral myocarditis_Homo sapiens_hsa054161.75271675
18Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.67870693
19Antigen processing and presentation_Homo sapiens_hsa046121.62275177
20Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44621357
21Ether lipid metabolism_Homo sapiens_hsa005651.41035914
22Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.33928330
23Tuberculosis_Homo sapiens_hsa051521.27918795
24Platelet activation_Homo sapiens_hsa046111.21325250
25Toxoplasmosis_Homo sapiens_hsa051451.21079157
26Complement and coagulation cascades_Homo sapiens_hsa046101.18568271
27Asthma_Homo sapiens_hsa053101.13831406
28Herpes simplex infection_Homo sapiens_hsa051681.13211900
29Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.12333643
30Pancreatic cancer_Homo sapiens_hsa052121.11617567
31RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.10133544
32Hematopoietic cell lineage_Homo sapiens_hsa046401.08519458
33Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.05136335
34Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.02779190
35Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.95452644
36Legionellosis_Homo sapiens_hsa051340.95389270
37Chronic myeloid leukemia_Homo sapiens_hsa052200.95206026
38Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.91513278
39Renin secretion_Homo sapiens_hsa049240.89299995
40* Chemokine signaling pathway_Homo sapiens_hsa040620.87988545
41Measles_Homo sapiens_hsa051620.86187894
42Salmonella infection_Homo sapiens_hsa051320.85354102
43Hepatitis C_Homo sapiens_hsa051600.84463380
44Colorectal cancer_Homo sapiens_hsa052100.84434348
45Rheumatoid arthritis_Homo sapiens_hsa053230.83651295
46Endocytosis_Homo sapiens_hsa041440.81797148
47Nitrogen metabolism_Homo sapiens_hsa009100.80793797
48Phagosome_Homo sapiens_hsa041450.79869002
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.79598385
50Influenza A_Homo sapiens_hsa051640.78965627
51AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.78324041
52Renal cell carcinoma_Homo sapiens_hsa052110.75400422
53Leukocyte transendothelial migration_Homo sapiens_hsa046700.73495104
54Estrogen signaling pathway_Homo sapiens_hsa049150.73180354
55NF-kappa B signaling pathway_Homo sapiens_hsa040640.72599907
56NOD-like receptor signaling pathway_Homo sapiens_hsa046210.71762914
57* Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.71448130
58Salivary secretion_Homo sapiens_hsa049700.71282434
59MAPK signaling pathway_Homo sapiens_hsa040100.68818621
60Prolactin signaling pathway_Homo sapiens_hsa049170.68408749
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.66940267
62Regulation of autophagy_Homo sapiens_hsa041400.66608350
63T cell receptor signaling pathway_Homo sapiens_hsa046600.65178312
64ABC transporters_Homo sapiens_hsa020100.65024196
65Malaria_Homo sapiens_hsa051440.63202219
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.62655966
67Long-term potentiation_Homo sapiens_hsa047200.62647875
68Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62599790
69Sphingolipid signaling pathway_Homo sapiens_hsa040710.60273009
70Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.59461544
71Rap1 signaling pathway_Homo sapiens_hsa040150.59316635
72Hepatitis B_Homo sapiens_hsa051610.59018633
73African trypanosomiasis_Homo sapiens_hsa051430.58112835
74Epstein-Barr virus infection_Homo sapiens_hsa051690.57455107
75Endometrial cancer_Homo sapiens_hsa052130.57066981
76Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56300204
77Apoptosis_Homo sapiens_hsa042100.55855158
78Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55852470
79Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55170733
80Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54515618
81Phospholipase D signaling pathway_Homo sapiens_hsa040720.54216342
82Glycerophospholipid metabolism_Homo sapiens_hsa005640.53637906
83Notch signaling pathway_Homo sapiens_hsa043300.52379300
84TNF signaling pathway_Homo sapiens_hsa046680.52106164
85mTOR signaling pathway_Homo sapiens_hsa041500.51776640
86Olfactory transduction_Homo sapiens_hsa047400.51741533
87HTLV-I infection_Homo sapiens_hsa051660.51732078
88cAMP signaling pathway_Homo sapiens_hsa040240.51541612
89GnRH signaling pathway_Homo sapiens_hsa049120.51151655
90cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50622097
91Jak-STAT signaling pathway_Homo sapiens_hsa046300.50160609
92Arachidonic acid metabolism_Homo sapiens_hsa005900.50100830
93Viral carcinogenesis_Homo sapiens_hsa052030.49486466
94Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.48717108
95Oxytocin signaling pathway_Homo sapiens_hsa049210.47788939
96Adherens junction_Homo sapiens_hsa045200.47576724
97Glioma_Homo sapiens_hsa052140.45427758
98Ras signaling pathway_Homo sapiens_hsa040140.43869575
99Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.43812999
100Choline metabolism in cancer_Homo sapiens_hsa052310.43729820
101Graft-versus-host disease_Homo sapiens_hsa053320.43545681
102Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.42813089
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.40037414
104Type II diabetes mellitus_Homo sapiens_hsa049300.38866397
105HIF-1 signaling pathway_Homo sapiens_hsa040660.37529358
106Aldosterone synthesis and secretion_Homo sapiens_hsa049250.37431454
107Long-term depression_Homo sapiens_hsa047300.36389078
108Calcium signaling pathway_Homo sapiens_hsa040200.35529472
109ErbB signaling pathway_Homo sapiens_hsa040120.35461649
110Cocaine addiction_Homo sapiens_hsa050300.35361203
111Inositol phosphate metabolism_Homo sapiens_hsa005620.34935702
112Adipocytokine signaling pathway_Homo sapiens_hsa049200.34884812
113Shigellosis_Homo sapiens_hsa051310.34718208
114Morphine addiction_Homo sapiens_hsa050320.34697175
115Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.33696564
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33306413
117Cholinergic synapse_Homo sapiens_hsa047250.33099466
118Intestinal immune network for IgA production_Homo sapiens_hsa046720.32887462
119Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.32075646
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.32050061
121Glutamatergic synapse_Homo sapiens_hsa047240.31309309
122FoxO signaling pathway_Homo sapiens_hsa040680.31272737
123Dorso-ventral axis formation_Homo sapiens_hsa043200.31099797
124Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.30201622
125Acute myeloid leukemia_Homo sapiens_hsa052210.29699971
126Non-small cell lung cancer_Homo sapiens_hsa052230.29639255
127VEGF signaling pathway_Homo sapiens_hsa043700.28698221
128Amoebiasis_Homo sapiens_hsa051460.28617475

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