CXADR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a type I membrane receptor for group B coxsackieviruses and subgroup C adenoviruses. Several transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene are found on chromosomes 15, 18, and 21. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1pyrimidine nucleobase catabolic process (GO:0006208)9.47132390
2nucleobase catabolic process (GO:0046113)7.92868334
3layer formation in cerebral cortex (GO:0021819)5.44519721
4DNA double-strand break processing (GO:0000729)4.90783501
5presynaptic membrane assembly (GO:0097105)4.42281609
6cellular ketone body metabolic process (GO:0046950)4.41360661
7central nervous system projection neuron axonogenesis (GO:0021952)3.99141170
8presynaptic membrane organization (GO:0097090)3.87663782
9dendritic spine morphogenesis (GO:0060997)3.84546476
10cell migration in hindbrain (GO:0021535)3.83236973
11dendrite morphogenesis (GO:0048813)3.81726809
12axon extension (GO:0048675)3.79319080
13ketone body metabolic process (GO:1902224)3.77324196
14vocalization behavior (GO:0071625)3.74745058
15mitochondrion transport along microtubule (GO:0047497)3.68258667
16establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.68258667
17neuron recognition (GO:0008038)3.61047642
18DNA damage response, detection of DNA damage (GO:0042769)3.60290312
19cullin deneddylation (GO:0010388)3.49288154
20limb bud formation (GO:0060174)3.49189068
21neuron cell-cell adhesion (GO:0007158)3.47376918
22L-phenylalanine catabolic process (GO:0006559)3.43945578
23erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.43945578
24axonal fasciculation (GO:0007413)3.42263761
25regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.41536487
26regulation of mitotic spindle checkpoint (GO:1903504)3.41536487
27neuron projection extension (GO:1990138)3.33589563
28negative regulation of DNA recombination (GO:0045910)3.28061864
29postsynaptic membrane organization (GO:0001941)3.26788136
30alpha-linolenic acid metabolic process (GO:0036109)3.20895678
31negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.20383162
32negative regulation of translation, ncRNA-mediated (GO:0040033)3.20383162
33regulation of translation, ncRNA-mediated (GO:0045974)3.20383162
34erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.19773875
35L-phenylalanine metabolic process (GO:0006558)3.19773875
36protein deneddylation (GO:0000338)3.16063460
37establishment of mitochondrion localization (GO:0051654)3.14792558
38positive regulation of filopodium assembly (GO:0051491)3.13109733
39glyoxylate metabolic process (GO:0046487)3.12081240
40exploration behavior (GO:0035640)3.11241853
41central nervous system neuron axonogenesis (GO:0021955)3.09761380
42triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.08358015
43histone H2A acetylation (GO:0043968)3.06850262
44proline transport (GO:0015824)3.06297645
45negative regulation of fibrinolysis (GO:0051918)3.05103961
46neurotransmitter-gated ion channel clustering (GO:0072578)3.04900193
47regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02427879
48aromatic amino acid family catabolic process (GO:0009074)3.01418529
49locomotory exploration behavior (GO:0035641)2.99066114
50positive regulation of axon extension (GO:0045773)2.98931574
51regulation of fibrinolysis (GO:0051917)2.98845767
52chromatin remodeling at centromere (GO:0031055)2.98472237
53urea metabolic process (GO:0019627)2.96036870
54urea cycle (GO:0000050)2.96036870
55regulation of helicase activity (GO:0051095)2.95819974
56cerebral cortex neuron differentiation (GO:0021895)2.91899441
57protein localization to synapse (GO:0035418)2.87931471
58sulfur amino acid catabolic process (GO:0000098)2.86638690
59kynurenine metabolic process (GO:0070189)2.86567479
60midgut development (GO:0007494)2.86232768
61clathrin coat assembly (GO:0048268)2.84352531
62negative regulation of DNA-dependent DNA replication (GO:2000104)2.81178670
63regulation of glutamate receptor signaling pathway (GO:1900449)2.78830625
64bile acid biosynthetic process (GO:0006699)2.78638502
65high-density lipoprotein particle remodeling (GO:0034375)2.78426512
66desmosome organization (GO:0002934)2.77935533
67bile acid and bile salt transport (GO:0015721)2.77576623
68positive regulation of synapse maturation (GO:0090129)2.77249003
69negative regulation of microtubule polymerization (GO:0031115)2.75717729
70pyrimidine-containing compound catabolic process (GO:0072529)2.75573186
71neural tube formation (GO:0001841)2.75141148
72indole-containing compound catabolic process (GO:0042436)2.72763839
73indolalkylamine catabolic process (GO:0046218)2.72763839
74tryptophan catabolic process (GO:0006569)2.72763839
75epithelial cell differentiation involved in kidney development (GO:0035850)2.72540267
76regulation of short-term neuronal synaptic plasticity (GO:0048172)2.71258283
77retinal ganglion cell axon guidance (GO:0031290)2.70355227
78glial cell proliferation (GO:0014009)2.69897612
79cellular glucuronidation (GO:0052695)2.69206867
80drug catabolic process (GO:0042737)2.68902461
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.68078465
82CENP-A containing nucleosome assembly (GO:0034080)2.67715322
83regulation of synapse structural plasticity (GO:0051823)2.67531354
84regulation of telomere maintenance (GO:0032204)2.67213366
85positive regulation of mitochondrial fission (GO:0090141)2.67058472
86histone exchange (GO:0043486)2.66333967
87negative regulation of sterol transport (GO:0032372)2.66166805
88negative regulation of cholesterol transport (GO:0032375)2.66166805
89somatic diversification of immune receptors via somatic mutation (GO:0002566)2.64866689
90somatic hypermutation of immunoglobulin genes (GO:0016446)2.64866689
91regulation of protein activation cascade (GO:2000257)2.64584125
92positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.64558166
93synaptic vesicle maturation (GO:0016188)2.64056166
94bundle of His cell to Purkinje myocyte communication (GO:0086069)2.63774726
95cysteine metabolic process (GO:0006534)2.63401226
96single strand break repair (GO:0000012)2.63190958
97olfactory bulb development (GO:0021772)2.62219691
98protein localization to cilium (GO:0061512)2.61624480
99developmental cell growth (GO:0048588)2.61418096
100L-serine metabolic process (GO:0006563)2.60647465
101establishment of integrated proviral latency (GO:0075713)2.59327412
102cellular response to prostaglandin stimulus (GO:0071379)2.59269953
103protein neddylation (GO:0045116)2.59057593
104regulation of filopodium assembly (GO:0051489)2.58801659
105DNA catabolic process, exonucleolytic (GO:0000738)2.58615734
106DNA replication checkpoint (GO:0000076)2.58555680
107regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.58493771
108homocysteine metabolic process (GO:0050667)2.58206129
109cerebral cortex radially oriented cell migration (GO:0021799)2.57869289
110negative regulation of keratinocyte proliferation (GO:0010839)2.57493567
111cell junction maintenance (GO:0034331)2.57489840
112complement activation, alternative pathway (GO:0006957)2.57293180
113replication fork processing (GO:0031297)2.56849158
114nitrogen cycle metabolic process (GO:0071941)2.56587510
115positive regulation of microtubule polymerization or depolymerization (GO:0031112)2.55980694
116bile acid metabolic process (GO:0008206)2.55679142
117positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55642908
118reverse cholesterol transport (GO:0043691)2.55626345
119gamma-aminobutyric acid transport (GO:0015812)2.54889842
120tryptophan metabolic process (GO:0006568)2.54063515
121peptidyl-glutamic acid carboxylation (GO:0017187)2.52909545
122protein carboxylation (GO:0018214)2.52909545
123somite development (GO:0061053)2.52471311
124synapse assembly (GO:0007416)2.52326222
125regulation of dendritic spine morphogenesis (GO:0061001)2.52098487
126female gonad development (GO:0008585)2.50468066
127positive regulation of dendritic spine morphogenesis (GO:0061003)2.49706348
128homophilic cell adhesion via plasma membrane adhesion molecules (GO:0007156)2.48367628
129microtubule depolymerization (GO:0007019)2.48310929
130glutamate secretion (GO:0014047)2.48187298
131negative regulation of transcription regulatory region DNA binding (GO:2000678)2.48106697
132negative regulation of lipase activity (GO:0060192)2.48031502
133DNA replication-dependent nucleosome organization (GO:0034723)2.47833972
134DNA replication-dependent nucleosome assembly (GO:0006335)2.47833972
135regulation of collateral sprouting (GO:0048670)2.47525236
136kidney morphogenesis (GO:0060993)2.47102517
137serine family amino acid catabolic process (GO:0009071)2.46950223
138regulation of axon extension (GO:0030516)2.46658496
139negative regulation of catenin import into nucleus (GO:0035414)2.46630395
140water-soluble vitamin biosynthetic process (GO:0042364)2.46505948
141C4-dicarboxylate transport (GO:0015740)2.45763024
142negative regulation of telomere maintenance (GO:0032205)2.45348118
143intraciliary transport (GO:0042073)2.45176248
144lysine catabolic process (GO:0006554)2.44161141
145lysine metabolic process (GO:0006553)2.44161141
146alanine transport (GO:0032328)2.43838841
147regulation of cAMP-dependent protein kinase activity (GO:2000479)2.43797631
148regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.43507980
149neuron migration (GO:0001764)2.43451072
150phospholipid efflux (GO:0033700)2.43136581
151regulation of coenzyme metabolic process (GO:0051196)2.42169735
152regulation of cofactor metabolic process (GO:0051193)2.42169735
153telomere maintenance via telomerase (GO:0007004)2.41804870
154nonmotile primary cilium assembly (GO:0035058)2.41240865
155regulation of telomere maintenance via telomerase (GO:0032210)2.39219074
156protein-cofactor linkage (GO:0018065)2.37638991
157cholesterol biosynthetic process (GO:0006695)2.34351852
158response to pheromone (GO:0019236)2.33917422
159proteasome assembly (GO:0043248)2.33713291
160exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.33485281
161G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.32851416
162mitotic spindle checkpoint (GO:0071174)2.32309594
163regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.32049458
164peptidyl-cysteine modification (GO:0018198)2.32038793
165atrial cardiac muscle cell action potential (GO:0086014)2.31556744
166DNA replication-independent nucleosome assembly (GO:0006336)2.31553331
167DNA replication-independent nucleosome organization (GO:0034724)2.31553331
168regulation of acyl-CoA biosynthetic process (GO:0050812)2.31034446
169nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.30565056
170DNA integration (GO:0015074)2.29922700
171negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.29898264
172negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.29898264
173negative regulation of mitotic sister chromatid segregation (GO:0033048)2.29898264
174negative regulation of mitotic sister chromatid separation (GO:2000816)2.29898264
175negative regulation of sister chromatid segregation (GO:0033046)2.29898264
176behavioral response to nicotine (GO:0035095)2.29518262
177non-recombinational repair (GO:0000726)2.29429259
178double-strand break repair via nonhomologous end joining (GO:0006303)2.29429259
179spindle checkpoint (GO:0031577)2.29428715
180sympathetic nervous system development (GO:0048485)2.27933084
181fatty acid elongation (GO:0030497)2.27779262
182resolution of meiotic recombination intermediates (GO:0000712)2.26759436
183organelle disassembly (GO:1903008)2.25604682
184regulation of development, heterochronic (GO:0040034)2.23732420
185microtubule polymerization or depolymerization (GO:0031109)2.23334419
186calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.22500315
187short-term memory (GO:0007614)2.21722671

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.12181195
2EZH2_22144423_ChIP-Seq_EOC_Human3.01771711
3TP63_17297297_ChIP-ChIP_HaCaT_Human2.84440413
4IGF1R_20145208_ChIP-Seq_DFB_Human2.81112549
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.61446921
6* POU3F2_20337985_ChIP-ChIP_501MEL_Human2.54490068
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.42535542
8* FUS_26573619_Chip-Seq_HEK293_Human2.40816193
9VDR_22108803_ChIP-Seq_LS180_Human2.40400564
10EWS_26573619_Chip-Seq_HEK293_Human2.33501187
11* RXR_22158963_ChIP-Seq_LIVER_Mouse2.24227758
12NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.17557490
13MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.17483428
14GBX2_23144817_ChIP-Seq_PC3_Human2.10080229
15HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.05385086
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.03290493
17E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.00088028
18SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.99857617
19AR_21572438_ChIP-Seq_LNCaP_Human1.99202622
20JARID2_20064375_ChIP-Seq_MESCs_Mouse1.98945316
21POU5F1_16153702_ChIP-ChIP_HESCs_Human1.98410302
22SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.98223175
23* EZH2_27304074_Chip-Seq_ESCs_Mouse1.98196953
24FLI1_27457419_Chip-Seq_LIVER_Mouse1.96810268
25EST1_17652178_ChIP-ChIP_JURKAT_Human1.89880500
26GABP_17652178_ChIP-ChIP_JURKAT_Human1.89537374
27TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.87193017
28RBPJ_22232070_ChIP-Seq_NCS_Mouse1.84346129
29RNF2_18974828_ChIP-Seq_MESCs_Mouse1.84111130
30EZH2_18974828_ChIP-Seq_MESCs_Mouse1.84111130
31SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.83031849
32* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.82077762
33* LXR_22158963_ChIP-Seq_LIVER_Mouse1.80950543
34JARID2_20075857_ChIP-Seq_MESCs_Mouse1.78579368
35EZH2_27294783_Chip-Seq_ESCs_Mouse1.78465609
36NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.78455672
37ZNF263_19887448_ChIP-Seq_K562_Human1.76357141
38* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.75845037
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71906137
40FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.71544876
41E2F4_17652178_ChIP-ChIP_JURKAT_Human1.71090828
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.70461799
43ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.69917304
44EED_16625203_ChIP-ChIP_MESCs_Mouse1.67075700
45TRIM28_21343339_ChIP-Seq_HEK293_Human1.66735687
46SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.65508692
47GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65014454
48MTF2_20144788_ChIP-Seq_MESCs_Mouse1.63117302
49SUZ12_27294783_Chip-Seq_ESCs_Mouse1.60975902
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.60262003
51ELK1_19687146_ChIP-ChIP_HELA_Human1.55949803
52* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55200275
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.53866973
54* CTBP2_25329375_ChIP-Seq_LNCAP_Human1.50835578
55ZNF274_21170338_ChIP-Seq_K562_Hela1.49494660
56AHR_22903824_ChIP-Seq_MCF-7_Human1.48880030
57SOX2_16153702_ChIP-ChIP_HESCs_Human1.48447548
58MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.47241315
59DROSHA_22980978_ChIP-Seq_HELA_Human1.44756357
60* REST_21632747_ChIP-Seq_MESCs_Mouse1.44386585
61KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43525748
62UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42602086
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.41999885
64NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.41440410
65ERG_21242973_ChIP-ChIP_JURKAT_Human1.41255070
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.40610275
67MYC_18940864_ChIP-ChIP_HL60_Human1.36354866
68* ARNT_22903824_ChIP-Seq_MCF-7_Human1.36205774
69IRF1_19129219_ChIP-ChIP_H3396_Human1.34377661
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.34309970
71CDX2_20551321_ChIP-Seq_CACO-2_Human1.33850647
72MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.33021759
73* NANOG_16153702_ChIP-ChIP_HESCs_Human1.32091285
74TAF15_26573619_Chip-Seq_HEK293_Human1.31750682
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.31015096
76CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.30871516
77PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28230148
78TCF4_18268006_ChIP-ChIP_LS174T_Human1.27719032
79AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.26325984
80SALL1_21062744_ChIP-ChIP_HESCs_Human1.26223215
81PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25550051
82PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.25467824
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.24539468
84GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.24277518
85RING1B_27294783_Chip-Seq_ESCs_Mouse1.23681873
86E2F7_22180533_ChIP-Seq_HELA_Human1.22541313
87FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.22517594
88RING1B_27294783_Chip-Seq_NPCs_Mouse1.22495061
89BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.21800657
90SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21273389
91* SOX2_21211035_ChIP-Seq_LN229_Gbm1.21174136
92CBP_20019798_ChIP-Seq_JUKART_Human1.20985011
93IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.20985011
94TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.20602652
95CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19784846
96STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19474792
97KLF5_20875108_ChIP-Seq_MESCs_Mouse1.19474375
98ER_23166858_ChIP-Seq_MCF-7_Human1.19329204
99CREB1_15753290_ChIP-ChIP_HEK293T_Human1.18890049
100SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17601565
101CBX2_27304074_Chip-Seq_ESCs_Mouse1.17338709
102PADI4_21655091_ChIP-ChIP_MCF-7_Human1.17204906
103RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.16236171
104CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.16107398
105EZH2_27294783_Chip-Seq_NPCs_Mouse1.14166507
106EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14151427
107TOP2B_26459242_ChIP-Seq_MCF-7_Human1.14119056
108TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12922369
109STAT3_23295773_ChIP-Seq_U87_Human1.12356041
110EGR1_23403033_ChIP-Seq_LIVER_Mouse1.12121820
111ESR2_21235772_ChIP-Seq_MCF-7_Human1.11571833
112* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.11507546
113* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.11507546
114TP53_18474530_ChIP-ChIP_U2OS_Human1.10845098
115REST_18959480_ChIP-ChIP_MESCs_Mouse1.10487952
116TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09520314
117NANOG_18555785_Chip-Seq_ESCs_Mouse1.09367856
118RUNX2_22187159_ChIP-Seq_PCA_Human1.08763752
119TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.07545677
120SMAD4_21741376_ChIP-Seq_HESCs_Human1.07363823
121SMAD4_21799915_ChIP-Seq_A2780_Human1.07314311
122WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.06220667
123SMAD3_21741376_ChIP-Seq_EPCs_Human1.04976756
124NFE2_27457419_Chip-Seq_LIVER_Mouse1.04943473
125TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.04253569
126PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.03516410
127TCF4_22108803_ChIP-Seq_LS180_Human1.03133245
128RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.03012052
129KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00976787
130VDR_23849224_ChIP-Seq_CD4+_Human1.00415802
131EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.00196363
132TBX3_20139965_ChIP-Seq_ESCs_Mouse1.00059066
133SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.99977833
134* ZFP281_18757296_ChIP-ChIP_E14_Mouse0.99856351
135TCF4_23295773_ChIP-Seq_U87_Human0.99843279
136GATA1_26923725_Chip-Seq_HPCs_Mouse0.99779490
137JUN_21703547_ChIP-Seq_K562_Human0.99617767
138WT1_25993318_ChIP-Seq_PODOCYTE_Human0.99514582
139BCAT_22108803_ChIP-Seq_LS180_Human0.99433440
140TBX3_20139965_ChIP-Seq_MESCs_Mouse0.99246423
141ISL1_27105846_Chip-Seq_CPCs_Mouse0.98257862
142STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse0.98029767
143MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.97315754
144NANOG_19829295_ChIP-Seq_ESCs_Human0.97308666
145SOX2_19829295_ChIP-Seq_ESCs_Human0.97308666
146CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97222821
147ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96902630
148TP63_19390658_ChIP-ChIP_HaCaT_Human0.96860676
149EP300_21415370_ChIP-Seq_HL-1_Mouse0.96523299
150* AR_25329375_ChIP-Seq_VCAP_Human0.96190307
151CLOCK_20551151_ChIP-Seq_293T_Human0.95717269
152ETS1_20019798_ChIP-Seq_JURKAT_Human0.95415494
153YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.94880916
154AR_19668381_ChIP-Seq_PC3_Human0.93807521
155P300_19829295_ChIP-Seq_ESCs_Human0.93795554
156* FOXA2_19822575_ChIP-Seq_HepG2_Human0.93698096
157BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93511783
158OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93309387
159KDM2B_26808549_Chip-Seq_K562_Human0.93122933
160FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.92947467
161* SOX9_26525672_Chip-Seq_HEART_Mouse0.92921066
162BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92228787
163ESR1_21235772_ChIP-Seq_MCF-7_Human0.92035612
164RNF2_27304074_Chip-Seq_NSC_Mouse0.91495322
165TP53_16413492_ChIP-PET_HCT116_Human0.91284357
166RARB_27405468_Chip-Seq_BRAIN_Mouse0.91242134
167NR3C1_21868756_ChIP-Seq_MCF10A_Human0.91157999
168SOX2_20726797_ChIP-Seq_SW620_Human0.90986102
169SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.89227433

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.12539129
2MP0005360_urolithiasis3.77390233
3MP0005085_abnormal_gallbladder_physiolo3.72310004
4MP0010234_abnormal_vibrissa_follicle3.53954302
5MP0005365_abnormal_bile_salt3.18148944
6MP0002102_abnormal_ear_morphology2.94361033
7MP0001529_abnormal_vocalization2.87607041
8MP0000537_abnormal_urethra_morphology2.87601263
9MP0008877_abnormal_DNA_methylation2.86635201
10MP0003122_maternal_imprinting2.77384112
11MP0008875_abnormal_xenobiotic_pharmacok2.60587028
12MP0000778_abnormal_nervous_system2.56160871
13MP0001188_hyperpigmentation2.56016292
14MP0004270_analgesia2.51950679
15MP0004859_abnormal_synaptic_plasticity2.46507881
16MP0009780_abnormal_chondrocyte_physiolo2.45137789
17MP0003787_abnormal_imprinting2.41678754
18MP0003121_genomic_imprinting2.41673514
19MP0003252_abnormal_bile_duct2.31269832
20MP0005187_abnormal_penis_morphology2.25419144
21MP0008058_abnormal_DNA_repair2.15848644
22MP0000569_abnormal_digit_pigmentation2.02137689
23MP0002736_abnormal_nociception_after2.01158131
24MP0009053_abnormal_anal_canal1.98022089
25MP0005423_abnormal_somatic_nervous1.94256001
26MP0002796_impaired_skin_barrier1.93296344
27MP0005248_abnormal_Harderian_gland1.92436453
28MP0010329_abnormal_lipoprotein_level1.90152704
29MP0001666_abnormal_nutrient_absorption1.87588471
30MP0000579_abnormal_nail_morphology1.86574443
31MP0009379_abnormal_foot_pigmentation1.83879020
32MP0006292_abnormal_olfactory_placode1.83260586
33MP0003329_amyloid_beta_deposits1.80360915
34MP0004885_abnormal_endolymph1.79611070
35MP0003705_abnormal_hypodermis_morpholog1.78418322
36MP0002751_abnormal_autonomic_nervous1.74075850
37MP0003119_abnormal_digestive_system1.67969844
38MP0003635_abnormal_synaptic_transmissio1.65917120
39MP0002063_abnormal_learning/memory/cond1.65635030
40MP0005083_abnormal_biliary_tract1.64408177
41MP0003868_abnormal_feces_composition1.61248195
42MP0004133_heterotaxia1.59528384
43MP0001293_anophthalmia1.57032516
44MP0009046_muscle_twitch1.55359807
45MP0002822_catalepsy1.54946693
46MP0002234_abnormal_pharynx_morphology1.53665302
47MP0003937_abnormal_limbs/digits/tail_de1.52858138
48MP0003941_abnormal_skin_development1.52152889
49MP0003718_maternal_effect1.50736580
50MP0003880_abnormal_central_pattern1.48922569
51MP0002734_abnormal_mechanical_nocicepti1.46216207
52MP0002184_abnormal_innervation1.46112915
53MP0003693_abnormal_embryo_hatching1.44920352
54MP0010094_abnormal_chromosome_stability1.43886603
55MP0002938_white_spotting1.40612833
56MP0006072_abnormal_retinal_apoptosis1.40250656
57MP0004019_abnormal_vitamin_homeostasis1.37293075
58MP0002272_abnormal_nervous_system1.36397132
59MP0008789_abnormal_olfactory_epithelium1.35520993
60MP0005551_abnormal_eye_electrophysiolog1.34123648
61MP0002254_reproductive_system_inflammat1.29952471
62MP0000049_abnormal_middle_ear1.27831855
63MP0000462_abnormal_digestive_system1.26201006
64MP0002909_abnormal_adrenal_gland1.25616578
65MP0005253_abnormal_eye_physiology1.25601070
66MP0010678_abnormal_skin_adnexa1.22262637
67MP0008057_abnormal_DNA_replication1.21619474
68MP0002557_abnormal_social/conspecific_i1.19991965
69MP0003890_abnormal_embryonic-extraembry1.19129506
70MP0008932_abnormal_embryonic_tissue1.18312065
71MP0001485_abnormal_pinna_reflex1.16794410
72MP0001440_abnormal_grooming_behavior1.16757922
73MP0002098_abnormal_vibrissa_morphology1.13968410
74MP0002733_abnormal_thermal_nociception1.13406038
75MP0003879_abnormal_hair_cell1.13189447
76MP0001286_abnormal_eye_development1.09231071
77MP0004811_abnormal_neuron_physiology1.08991479
78MP0006276_abnormal_autonomic_nervous1.08304073
79MP0002138_abnormal_hepatobiliary_system1.08126967
80MP0003011_delayed_dark_adaptation1.07338537
81MP0005394_taste/olfaction_phenotype1.04759663
82MP0005499_abnormal_olfactory_system1.04759663
83MP0004858_abnormal_nervous_system1.04006482
84MP0002067_abnormal_sensory_capabilities1.03627631
85MP0002752_abnormal_somatic_nervous1.03524961
86MP0000467_abnormal_esophagus_morphology1.02815842
87MP0000955_abnormal_spinal_cord1.02737242
88MP0002233_abnormal_nose_morphology1.01917043
89MP0010352_gastrointestinal_tract_polyps1.01218478
90MP0003123_paternal_imprinting0.99825944
91MP0004215_abnormal_myocardial_fiber0.99615288
92MP0002064_seizures0.99594287
93MP0003755_abnormal_palate_morphology0.99319372
94MP0002118_abnormal_lipid_homeostasis0.98634776
95MP0002697_abnormal_eye_size0.98634211
96MP0000604_amyloidosis0.97910060
97MP0002572_abnormal_emotion/affect_behav0.97714074
98MP0009672_abnormal_birth_weight0.96101914
99MP0003136_yellow_coat_color0.94991656
100MP0004957_abnormal_blastocyst_morpholog0.94030802
101MP0005367_renal/urinary_system_phenotyp0.93656589
102MP0000516_abnormal_urinary_system0.93656589
103MP0000566_synostosis0.93459532
104MP0004130_abnormal_muscle_cell0.92833188
105MP0001984_abnormal_olfaction0.92388877
106MP0002735_abnormal_chemical_nociception0.91911325
107MP0008995_early_reproductive_senescence0.91683762
108MP0001486_abnormal_startle_reflex0.91633016
109MP0002090_abnormal_vision0.90721562
110MP0003861_abnormal_nervous_system0.90160694
111MP0009703_decreased_birth_body0.90122999
112MP0001177_atelectasis0.89882765
113MP0002638_abnormal_pupillary_reflex0.89628745
114MP0009745_abnormal_behavioral_response0.89461337
115MP0004924_abnormal_behavior0.88983290
116MP0005386_behavior/neurological_phenoty0.88983290
117MP0000538_abnormal_urinary_bladder0.88602658
118MP0005501_abnormal_skin_physiology0.86535506
119MP0002152_abnormal_brain_morphology0.86158587
120MP0005391_vision/eye_phenotype0.85949728
121MP0004742_abnormal_vestibular_system0.85347128
122MP0000647_abnormal_sebaceous_gland0.85062072
123MP0003111_abnormal_nucleus_morphology0.84721130
124MP0001970_abnormal_pain_threshold0.83294722
125MP0008007_abnormal_cellular_replicative0.83258721
126MP0005195_abnormal_posterior_eye0.82537419
127MP0004142_abnormal_muscle_tone0.81294231
128MP0010368_abnormal_lymphatic_system0.80707258
129MP0001849_ear_inflammation0.80126371
130MP0005084_abnormal_gallbladder_morpholo0.79390434
131MP0000631_abnormal_neuroendocrine_gland0.79023419
132* MP0003567_abnormal_fetal_cardiomyocyte0.78582773
133MP0002653_abnormal_ependyma_morphology0.78270096
134MP0003385_abnormal_body_wall0.78106609
135MP0002882_abnormal_neuron_morphology0.77432125
136MP0005332_abnormal_amino_acid0.77369749
137MP0002896_abnormal_bone_mineralization0.76279731
138MP0002069_abnormal_eating/drinking_beha0.75962044
139MP0003938_abnormal_ear_development0.74330584
140MP0003195_calcinosis0.73700581
141MP0001348_abnormal_lacrimal_gland0.73451856
142MP0001968_abnormal_touch/_nociception0.70356017
143MP0003315_abnormal_perineum_morphology0.68896780
144MP0000383_abnormal_hair_follicle0.67900906
145MP0003942_abnormal_urinary_system0.66654061
146MP0000534_abnormal_ureter_morphology0.65882174
147MP0000762_abnormal_tongue_morphology0.65428928
148MP0000609_abnormal_liver_physiology0.64792572
149MP0003115_abnormal_respiratory_system0.64268296
150MP0000026_abnormal_inner_ear0.63082779
151MP0005220_abnormal_exocrine_pancreas0.60633440
152MP0000377_abnormal_hair_follicle0.59903767
153MP0009384_cardiac_valve_regurgitation0.59394816
154MP0001299_abnormal_eye_distance/0.58741710
155MP0001340_abnormal_eyelid_morphology0.58720555

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the labia minora (HP:0012880)4.74811250
2Deep venous thrombosis (HP:0002625)4.14188665
3Epidermoid cyst (HP:0200040)4.10116156
4Amyotrophic lateral sclerosis (HP:0007354)3.85687026
5Hepatoblastoma (HP:0002884)3.72479607
6Cortical dysplasia (HP:0002539)3.65640744
7Intrahepatic cholestasis (HP:0001406)3.62214031
8Mutism (HP:0002300)3.61655647
9Hypobetalipoproteinemia (HP:0003563)3.36470644
10Abnormality of monocarboxylic acid metabolism (HP:0010996)3.31332999
11Drooling (HP:0002307)3.27508037
12Excessive salivation (HP:0003781)3.27508037
13Akinesia (HP:0002304)3.22768431
14Colon cancer (HP:0003003)3.18012215
15Right ventricular cardiomyopathy (HP:0011663)3.17593777
16Cerebral inclusion bodies (HP:0100314)3.14506895
17Xanthomatosis (HP:0000991)3.05690040
18Subacute progressive viral hepatitis (HP:0006572)2.99393746
19Abnormality of the corticospinal tract (HP:0002492)2.92728408
20Neurofibrillary tangles (HP:0002185)2.80306904
21Morphological abnormality of the pyramidal tract (HP:0002062)2.79843700
22Abnormality of aromatic amino acid family metabolism (HP:0004338)2.77789421
23Prolonged partial thromboplastin time (HP:0003645)2.70650091
24Pachygyria (HP:0001302)2.69774700
25Limb dystonia (HP:0002451)2.63284411
26Gait imbalance (HP:0002141)2.61228908
27Pancreatic cysts (HP:0001737)2.60521825
28True hermaphroditism (HP:0010459)2.59101970
29Hyperventilation (HP:0002883)2.56089755
30Supranuclear gaze palsy (HP:0000605)2.55401654
31Genital tract atresia (HP:0001827)2.54138616
32Insidious onset (HP:0003587)2.54092105
33Termporal pattern (HP:0011008)2.54092105
34Medial flaring of the eyebrow (HP:0010747)2.53918028
35Lymphangioma (HP:0100764)2.53286899
36Vaginal atresia (HP:0000148)2.51854476
37Inappropriate behavior (HP:0000719)2.51371762
38Hepatocellular carcinoma (HP:0001402)2.48582264
39Complement deficiency (HP:0004431)2.45091040
40Disinhibition (HP:0000734)2.44340903
41Hypolipoproteinemia (HP:0010981)2.44064148
42Pancreatic fibrosis (HP:0100732)2.43923208
43Abnormality of the lower motor neuron (HP:0002366)2.43654036
44Congenital primary aphakia (HP:0007707)2.43588936
45Ependymoma (HP:0002888)2.43169697
46Labial hypoplasia (HP:0000066)2.37196435
47Progressive inability to walk (HP:0002505)2.35485057
48Nephrogenic diabetes insipidus (HP:0009806)2.34873356
49Torticollis (HP:0000473)2.34473654
50Ketoacidosis (HP:0001993)2.33771555
51Hyperlipoproteinemia (HP:0010980)2.32985674
52Hypoplastic female external genitalia (HP:0012815)2.30395488
53Methylmalonic acidemia (HP:0002912)2.30389176
54Agitation (HP:0000713)2.29854446
55Abnormality of midbrain morphology (HP:0002418)2.29099233
56Molar tooth sign on MRI (HP:0002419)2.29099233
57Polyphagia (HP:0002591)2.28414018
58Ketosis (HP:0001946)2.27716899
59Septo-optic dysplasia (HP:0100842)2.27405867
60Hyperglycinemia (HP:0002154)2.27138016
61Intestinal atresia (HP:0011100)2.26759535
62Abnormal lung lobation (HP:0002101)2.22131246
63Inability to walk (HP:0002540)2.19676585
64Abnormal hair whorl (HP:0010721)2.19112965
65Meckel diverticulum (HP:0002245)2.18639840
66Hypsarrhythmia (HP:0002521)2.18493781
67Scrotal hypoplasia (HP:0000046)2.15856732
68Conjugated hyperbilirubinemia (HP:0002908)2.15661508
69Medulloblastoma (HP:0002885)2.15281968
70Hypothermia (HP:0002045)2.14530595
71Bronchomalacia (HP:0002780)2.13885979
72Bifid tongue (HP:0010297)2.13457952
73Fat malabsorption (HP:0002630)2.13226414
74EEG with generalized epileptiform discharges (HP:0011198)2.12328518
75Aqueductal stenosis (HP:0002410)2.12175550
76Megalencephaly (HP:0001355)2.11821528
77Abnormality of the ileum (HP:0001549)2.10925207
78Birth length less than 3rd percentile (HP:0003561)2.08510901
79Abnormality of the astrocytes (HP:0100707)2.07987537
80Astrocytoma (HP:0009592)2.07987537
81Nephronophthisis (HP:0000090)2.07878727
82Abnormality of glutamine family amino acid metabolism (HP:0010902)2.07732688
83Abnormality of salivation (HP:0100755)2.05111726
84Glioma (HP:0009733)2.04896534
85Germ cell neoplasia (HP:0100728)2.04823064
86Fragile nails (HP:0001808)2.04504295
87Hypoalphalipoproteinemia (HP:0003233)2.04193357
88Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.03868354
89Myokymia (HP:0002411)2.03825770
90Abnormality of serum amino acid levels (HP:0003112)2.03391160
91Gout (HP:0001997)2.03144485
92Atonic seizures (HP:0010819)2.02649300
93Volvulus (HP:0002580)2.02358212
94Aplasia/Hypoplasia of the uvula (HP:0010293)2.01520424
95Epileptiform EEG discharges (HP:0011182)1.99826752
96Obstructive sleep apnea (HP:0002870)1.99674323
97Aplasia/Hypoplasia of the sternum (HP:0006714)1.99510744
98Neoplasm of the adrenal cortex (HP:0100641)1.99466601
99Specific learning disability (HP:0001328)1.97533595
100Micronodular cirrhosis (HP:0001413)1.96388877
101Optic nerve hypoplasia (HP:0000609)1.96263495
102Ankle clonus (HP:0011448)1.95910317
103Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.94879123
104Abnormality of chromosome stability (HP:0003220)1.94113050
105Renal hypoplasia (HP:0000089)1.94065145
106Focal motor seizures (HP:0011153)1.93621603
107Broad-based gait (HP:0002136)1.93352414
108Abolished electroretinogram (ERG) (HP:0000550)1.92981673
109Craniofacial dystonia (HP:0012179)1.92209671
110Pendular nystagmus (HP:0012043)1.90655831
111Stenosis of the external auditory canal (HP:0000402)1.90459733
112Poor suck (HP:0002033)1.90071912
113Abnormal social behavior (HP:0012433)1.89379838
114Impaired social interactions (HP:0000735)1.89379838
115Apathy (HP:0000741)1.89337501
116Papilledema (HP:0001085)1.88957160
117Anophthalmia (HP:0000528)1.88504163
118Abnormality of the labia (HP:0000058)1.88293428
119Broad foot (HP:0001769)1.86664998
120Focal dystonia (HP:0004373)1.86636513
121Methylmalonic aciduria (HP:0012120)1.86171380
122Visual hallucinations (HP:0002367)1.83835180
123Supernumerary spleens (HP:0009799)1.83317783
124Genetic anticipation (HP:0003743)1.82464381
125Preaxial hand polydactyly (HP:0001177)1.82392175
126Neonatal onset (HP:0003623)1.81193497
127Hyperglycinuria (HP:0003108)1.79946561
128Abnormality of serine family amino acid metabolism (HP:0010894)1.79338847
129Abnormality of glycine metabolism (HP:0010895)1.79338847
130Narrow forehead (HP:0000341)1.79027284
131Turricephaly (HP:0000262)1.78695340
132Poor eye contact (HP:0000817)1.78269427
133Dandy-Walker malformation (HP:0001305)1.77881186
134Exotropia (HP:0000577)1.77113498
135Postaxial hand polydactyly (HP:0001162)1.76294387
136Papillary thyroid carcinoma (HP:0002895)1.76121599
137Micropenis (HP:0000054)1.76120317
138Cupped ear (HP:0000378)1.74724242
139Ankyloglossia (HP:0010296)1.74085455
140Anencephaly (HP:0002323)1.74036024
141Spastic tetraplegia (HP:0002510)1.73767864
142Impaired vibration sensation in the lower limbs (HP:0002166)1.73069086
143Poor coordination (HP:0002370)1.72096426
144Decreased muscle mass (HP:0003199)1.71607304
145Patellar aplasia (HP:0006443)1.71277781
146Skin nodule (HP:0200036)1.71120338
147Acute necrotizing encephalopathy (HP:0006965)1.71078688
148Bilateral microphthalmos (HP:0007633)1.70830399
149Atrophy/Degeneration involving motor neurons (HP:0007373)1.70729809
150Acute encephalopathy (HP:0006846)1.70024090
151Abnormality of the clitoris (HP:0000056)1.69738571
152Delayed CNS myelination (HP:0002188)1.69514349
153Sclerocornea (HP:0000647)1.69088056
154Hyperammonemia (HP:0001987)1.68369099
155Abnormality of the metopic suture (HP:0005556)1.67897088
156Dialeptic seizures (HP:0011146)1.67893887
157Aplasia/Hypoplasia of the brainstem (HP:0007362)1.67696332
158Hypoplasia of the brainstem (HP:0002365)1.67696332
159Polymicrogyria (HP:0002126)1.66681431
160Oligodactyly (hands) (HP:0001180)1.66621637
161Abnormality of the common coagulation pathway (HP:0010990)1.66525300
162Absent septum pellucidum (HP:0001331)1.66035221
163Aplasia/Hypoplasia of the tibia (HP:0005772)1.65429719
164Focal seizures (HP:0007359)1.65281464
165Cutaneous finger syndactyly (HP:0010554)1.64178972
166Absent eyebrow (HP:0002223)1.64142902
167Aplasia/Hypoplasia of the tongue (HP:0010295)1.63634636
168Curly hair (HP:0002212)1.63577136
169Malnutrition (HP:0004395)1.63310899
170Abnormality of the renal medulla (HP:0100957)1.63072571
171Sloping forehead (HP:0000340)1.62877582
172Hamartoma of the eye (HP:0010568)1.61246904
173Lissencephaly (HP:0001339)1.61210656
174Abnormality of aspartate family amino acid metabolism (HP:0010899)1.61177062
175Decreased testicular size (HP:0008734)1.60920808
176Diminished motivation (HP:0000745)1.60647163
177Syncope (HP:0001279)1.60235514
178Urinary urgency (HP:0000012)1.59743964
179Neoplasm of the adrenal gland (HP:0100631)1.59329808
180Intellectual disability, profound (HP:0002187)1.58759265

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MARK18.48157053
2TRIM283.80298657
3DYRK22.98630846
4TNIK2.88163301
5MAP3K92.77315805
6ERBB32.58440722
7EPHB22.54881366
8MKNK22.50528843
9LATS22.42719074
10PHKG22.40358487
11PHKG12.40358487
12TSSK62.32050594
13MAP4K22.26000944
14SRPK12.17338654
15MST1R2.05418304
16MAP3K41.97619086
17LMTK21.95249269
18FRK1.94412533
19MKNK11.90543900
20BMPR1B1.87878868
21NTRK21.84932997
22MINK11.80700659
23ZAK1.75853421
24BUB11.73489946
25PLK31.73404765
26MAP3K21.61360900
27MAPK131.60805291
28NUAK11.57788667
29DAPK21.52955413
30KSR11.52226233
31DYRK31.46628271
32LATS11.45438485
33CASK1.44525481
34CSNK1G21.44370455
35ACVR1B1.40813168
36PAK31.36579669
37TTK1.32513465
38MAP2K41.31914753
39MAP2K71.30610004
40FGFR21.28761752
41PLK41.28365554
42CDC71.25641652
43SIK31.25021060
44GRK11.23823592
45BRSK21.22415947
46EPHA41.21020914
47SIK21.17931809
48PINK11.17844125
49NEK11.16456405
50WEE11.13621469
51FER1.06489063
52PKN11.06335059
53ERBB41.05575321
54CSNK1A1L1.05383627
55EPHA21.04768858
56NTRK31.03224308
57PAK61.02599152
58CSNK1G31.01715341
59KSR21.01262557
60PKN20.99623302
61VRK10.96883242
62STK38L0.96395279
63PRKCZ0.95871952
64PLK10.95763176
65ERBB20.95608194
66PNCK0.94513329
67RIPK10.94217806
68OXSR10.93658560
69TAOK10.92593743
70LIMK10.89313376
71CDK50.89278433
72DYRK1A0.87427821
73RPS6KA40.85993852
74RET0.85346553
75PIK3CA0.82261503
76BCR0.81426156
77CSNK1G10.81181157
78DDR20.80738458
79EIF2AK30.78733070
80RPS6KA20.77447697
81CAMKK10.77022684
82MST40.76903853
83TAF10.74500180
84EPHA30.73836455
85MARK20.73791048
86PRKCI0.73038546
87MAP2K60.72458342
88BCKDK0.71503247
89TGFBR10.70979950
90STK110.68937851
91WNK30.66899095
92ADRBK20.64841706
93NTRK10.64727389
94PTK60.64473092
95CAMK1G0.64066992
96FGFR40.62809124
97MAP3K60.62793046
98MAPK120.61339581
99FLT30.61187770
100PRKCG0.59982738
101SIK10.56924760
102DYRK1B0.56917831
103PRKAA10.56337667
104ATR0.55555780
105PDGFRA0.54367922
106PRKCE0.54220099
107GSK3A0.53541520
108ATM0.53169376
109CDK190.53138843
110STK390.52684876
111MAP2K10.52363668
112PLK20.52262023
113PBK0.52003231
114STK160.51711596
115NME10.51685790
116SCYL20.50242147
117ROCK10.50112337
118ABL20.47561268
119TRIB30.45914795
120INSRR0.45362421
121CSNK1D0.45334120
122STK240.45299110
123BRSK10.44447143
124TESK10.44230102
125CAMK2A0.43437641
126ALK0.43334119
127EIF2AK20.42161310
128PTK20.41926835
129CSNK1A10.41579629
130CDK140.40535714
131PDK40.40416597
132PDK30.40416597
133TYRO30.40266740
134VRK20.40076169
135UHMK10.39552599
136CDK180.39503607
137BRD40.39427125
138CDK150.39376229
139MET0.39155361
140CAMK2B0.38375923
141FGFR10.36918564
142ICK0.36680462
143FYN0.36050882
144PRKDC0.35631524
145MAPK40.35408723
146FGFR30.33466455
147MAP3K30.32631356
148CDK30.32332785
149YES10.32131160
150CHEK20.31798096
151PRKACB0.31100892
152CSNK1E0.30192671
153TIE10.29376991
154CSNK2A10.29037817
155MAP3K50.28707793
156NLK0.28507029

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.05762217
2Primary bile acid biosynthesis_Homo sapiens_hsa001202.83225334
3Protein export_Homo sapiens_hsa030602.68626464
4Butanoate metabolism_Homo sapiens_hsa006502.51478678
5Non-homologous end-joining_Homo sapiens_hsa034502.47132335
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.36827255
7Nitrogen metabolism_Homo sapiens_hsa009102.22946282
8Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.08527921
9Mismatch repair_Homo sapiens_hsa034301.99478481
10Arginine biosynthesis_Homo sapiens_hsa002201.96140213
11Proteasome_Homo sapiens_hsa030501.95501248
12Axon guidance_Homo sapiens_hsa043601.85771602
13Bile secretion_Homo sapiens_hsa049761.76022299
14Tryptophan metabolism_Homo sapiens_hsa003801.75999597
15Basal transcription factors_Homo sapiens_hsa030221.74497142
16Phototransduction_Homo sapiens_hsa047441.73990906
17Fanconi anemia pathway_Homo sapiens_hsa034601.72960431
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.66956320
19Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.65672161
20Fatty acid degradation_Homo sapiens_hsa000711.65435326
21Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.61693265
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60252329
23RNA degradation_Homo sapiens_hsa030181.58729193
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.57899797
25RNA polymerase_Homo sapiens_hsa030201.55283250
26Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.53576181
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52345598
28Complement and coagulation cascades_Homo sapiens_hsa046101.49931914
29Oxidative phosphorylation_Homo sapiens_hsa001901.48278606
30RNA transport_Homo sapiens_hsa030131.48115278
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43716633
32Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43437371
33Fat digestion and absorption_Homo sapiens_hsa049751.42904353
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.42497430
35Homologous recombination_Homo sapiens_hsa034401.41702497
36Parkinsons disease_Homo sapiens_hsa050121.41044587
37Fatty acid elongation_Homo sapiens_hsa000621.38969613
38Chemical carcinogenesis_Homo sapiens_hsa052041.38530947
39Sulfur metabolism_Homo sapiens_hsa009201.36352613
40Fatty acid metabolism_Homo sapiens_hsa012121.32347310
41Taste transduction_Homo sapiens_hsa047421.28285723
42Endometrial cancer_Homo sapiens_hsa052131.24902601
43Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24840837
44PPAR signaling pathway_Homo sapiens_hsa033201.24351984
45Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24067640
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.22471005
47Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.20558315
48Steroid hormone biosynthesis_Homo sapiens_hsa001401.19481736
49Nicotine addiction_Homo sapiens_hsa050331.19175295
50Retinol metabolism_Homo sapiens_hsa008301.17871709
51DNA replication_Homo sapiens_hsa030301.16967194
52Vitamin B6 metabolism_Homo sapiens_hsa007501.15193335
53Histidine metabolism_Homo sapiens_hsa003401.11538020
542-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09375107
55Steroid biosynthesis_Homo sapiens_hsa001001.08169977
56Spliceosome_Homo sapiens_hsa030401.06212063
57beta-Alanine metabolism_Homo sapiens_hsa004101.05902644
58Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04878287
59Phenylalanine metabolism_Homo sapiens_hsa003601.03487071
60Oocyte meiosis_Homo sapiens_hsa041141.02836739
61Base excision repair_Homo sapiens_hsa034101.00709410
62mRNA surveillance pathway_Homo sapiens_hsa030151.00149635
63Starch and sucrose metabolism_Homo sapiens_hsa005000.99699166
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.98984174
65Huntingtons disease_Homo sapiens_hsa050160.98500078
66GABAergic synapse_Homo sapiens_hsa047270.97537136
67Cell cycle_Homo sapiens_hsa041100.96296345
68Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.95604729
69Drug metabolism - other enzymes_Homo sapiens_hsa009830.94859413
70Propanoate metabolism_Homo sapiens_hsa006400.94149518
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.93473801
72Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92451039
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92418256
74Gap junction_Homo sapiens_hsa045400.90595227
75Ether lipid metabolism_Homo sapiens_hsa005650.89716617
76Dopaminergic synapse_Homo sapiens_hsa047280.89432798
77Hippo signaling pathway_Homo sapiens_hsa043900.88780031
78Caffeine metabolism_Homo sapiens_hsa002320.86051806
79Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.85410497
80Circadian entrainment_Homo sapiens_hsa047130.84302573
81Fatty acid biosynthesis_Homo sapiens_hsa000610.82360651
82Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.81382371
83Glutamatergic synapse_Homo sapiens_hsa047240.80945927
84Collecting duct acid secretion_Homo sapiens_hsa049660.80643548
85Basal cell carcinoma_Homo sapiens_hsa052170.80344629
86Peroxisome_Homo sapiens_hsa041460.79846319
87Type II diabetes mellitus_Homo sapiens_hsa049300.79693922
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79511559
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.78575205
90Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.78182212
91Tight junction_Homo sapiens_hsa045300.77200695
92Melanogenesis_Homo sapiens_hsa049160.76489514
93Biosynthesis of amino acids_Homo sapiens_hsa012300.75782477
94Regulation of autophagy_Homo sapiens_hsa041400.74296655
95Linoleic acid metabolism_Homo sapiens_hsa005910.73859292
96Cholinergic synapse_Homo sapiens_hsa047250.72909453
97Hedgehog signaling pathway_Homo sapiens_hsa043400.72753524
98ErbB signaling pathway_Homo sapiens_hsa040120.72735230
99Purine metabolism_Homo sapiens_hsa002300.72557885
100Renin secretion_Homo sapiens_hsa049240.72510281
101Tyrosine metabolism_Homo sapiens_hsa003500.71464905
102Estrogen signaling pathway_Homo sapiens_hsa049150.71242473
103Nucleotide excision repair_Homo sapiens_hsa034200.70836661
104Long-term potentiation_Homo sapiens_hsa047200.69591453
105Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.69011322
106Synaptic vesicle cycle_Homo sapiens_hsa047210.68947495
107Alzheimers disease_Homo sapiens_hsa050100.67150203
108Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67117456
109Colorectal cancer_Homo sapiens_hsa052100.67071391
110Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.66885892
111Insulin signaling pathway_Homo sapiens_hsa049100.66353385
112Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.65993462
113Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.65865833
114Cocaine addiction_Homo sapiens_hsa050300.65799715
115Cyanoamino acid metabolism_Homo sapiens_hsa004600.64372083
116Renal cell carcinoma_Homo sapiens_hsa052110.62888928
117Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62547222
118Vitamin digestion and absorption_Homo sapiens_hsa049770.62316097
119Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.62163904
120Arginine and proline metabolism_Homo sapiens_hsa003300.62072506
121alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.62018894
122Gastric acid secretion_Homo sapiens_hsa049710.61769625
123Metabolic pathways_Homo sapiens_hsa011000.61486014
124Insulin resistance_Homo sapiens_hsa049310.61053106
125One carbon pool by folate_Homo sapiens_hsa006700.60600613
126Carbon metabolism_Homo sapiens_hsa012000.59733127
127Wnt signaling pathway_Homo sapiens_hsa043100.58577128
128Glioma_Homo sapiens_hsa052140.58102071
129Olfactory transduction_Homo sapiens_hsa047400.57909731
130GnRH signaling pathway_Homo sapiens_hsa049120.57896495
131Aldosterone synthesis and secretion_Homo sapiens_hsa049250.57397000
132AMPK signaling pathway_Homo sapiens_hsa041520.57169716
133Prion diseases_Homo sapiens_hsa050200.57064204
134Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.56676554
135Salivary secretion_Homo sapiens_hsa049700.56620073
136Pyruvate metabolism_Homo sapiens_hsa006200.55040082
137Insulin secretion_Homo sapiens_hsa049110.54278120
138Selenocompound metabolism_Homo sapiens_hsa004500.53755648
139Adherens junction_Homo sapiens_hsa045200.53751103
140Amphetamine addiction_Homo sapiens_hsa050310.53397871
141Pyrimidine metabolism_Homo sapiens_hsa002400.53266049
142ABC transporters_Homo sapiens_hsa020100.52223784
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.51270807
144Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50734909
145Lysine degradation_Homo sapiens_hsa003100.50315052
146Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.50288341
147Morphine addiction_Homo sapiens_hsa050320.50163980
148Glucagon signaling pathway_Homo sapiens_hsa049220.49768302
149Cardiac muscle contraction_Homo sapiens_hsa042600.48715846
150Long-term depression_Homo sapiens_hsa047300.47400753
151Circadian rhythm_Homo sapiens_hsa047100.47301766
152Dorso-ventral axis formation_Homo sapiens_hsa043200.47218785
153Oxytocin signaling pathway_Homo sapiens_hsa049210.45880568
154Serotonergic synapse_Homo sapiens_hsa047260.40405868

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