ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	homocysteine metabolic process (GO:0050667)	7.78672598
2	sulfur amino acid catabolic process (GO:0000098)	7.71050450
3	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	7.10155966
4	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	7.10155966
5	regulation of plasminogen activation (GO:0010755)	7.09574245
6	cysteine metabolic process (GO:0006534)	6.27686178
7	microtubule nucleation (GO:0007020)	6.06507054
8	folic acid-containing compound biosynthetic process (GO:0009396)	6.05095646
9	purine nucleotide salvage (GO:0032261)	5.95631876
10	cochlea development (GO:0090102)	5.49513202
11	inner ear receptor cell development (GO:0060119)	5.39254480
12	innervation (GO:0060384)	5.36266716
13	adenosine metabolic process (GO:0046085)	5.28535611
14	protein-cofactor linkage (GO:0018065)	5.18820264
15	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	5.11932122
16	negative regulation of DNA biosynthetic process (GO:2000279)	4.98808000
17	behavioral response to nicotine (GO:0035095)	4.97719662
18	pyrimidine nucleobase catabolic process (GO:0006208)	4.74765883
19	L-serine metabolic process (GO:0006563)	4.66782224
20	white fat cell differentiation (GO:0050872)	4.61331430
21	galactose catabolic process (GO:0019388)	4.54831508
22	histone H4-K12 acetylation (GO:0043983)	4.50039679
23	positive regulation of endothelial cell differentiation (GO:0045603)	4.38502872
24	adaptation of signaling pathway (GO:0023058)	4.22807652
25	negative regulation of catenin import into nucleus (GO:0035414)	4.12778816
26	alternative mRNA splicing, via spliceosome (GO:0000380)	4.04990103
27	primary amino compound metabolic process (GO:1901160)	4.01581482
28	galactose metabolic process (GO:0006012)	3.97386963
29	neuronal action potential propagation (GO:0019227)	3.89893779
30	phosphatidylglycerol biosynthetic process (GO:0006655)	3.86382239
31	desmosome organization (GO:0002934)	3.85638646
32	folic acid transport (GO:0015884)	3.85241890
33	IMP biosynthetic process (GO:0006188)	3.83250161
34	mitochondrial RNA metabolic process (GO:0000959)	3.82182549
35	serine family amino acid biosynthetic process (GO:0009070)	3.78754521
36	protein-chromophore linkage (GO:0018298)	3.77779367
37	behavioral fear response (GO:0001662)	3.77425280
38	behavioral defense response (GO:0002209)	3.77425280
39	regulation of sequestering of triglyceride (GO:0010889)	3.69444263
40	photoreceptor cell differentiation (GO:0046530)	3.67712143
41	eye photoreceptor cell differentiation (GO:0001754)	3.67712143
42	nucleobase catabolic process (GO:0046113)	3.65158045
43	pteridine-containing compound biosynthetic process (GO:0042559)	3.64442609
44	negative regulation of Ras GTPase activity (GO:0034261)	3.60692616
45	cell migration involved in heart development (GO:0060973)	3.58080590
46	tRNA modification (GO:0006400)	3.56633393
47	platelet dense granule organization (GO:0060155)	3.56272943
48	nucleotide salvage (GO:0043173)	3.51221627
49	regulation of gonadotropin secretion (GO:0032276)	3.45872878
50	CENP-A containing nucleosome assembly (GO:0034080)	3.45003163
51	regulation of branching involved in salivary gland morphogenesis (GO:0060693)	3.43335537
52	establishment of mitochondrion localization (GO:0051654)	3.42475604
53	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.39173905
54	NADH dehydrogenase complex assembly (GO:0010257)	3.39173905
55	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.39173905
56	positive regulation of oligodendrocyte differentiation (GO:0048714)	3.33604016
57	negative regulation of keratinocyte proliferation (GO:0010839)	3.27048198
58	nucleoside transmembrane transport (GO:1901642)	3.25647511
59	chromatin remodeling at centromere (GO:0031055)	3.25243099
60	organic cation transport (GO:0015695)	3.23390394
61	inner mitochondrial membrane organization (GO:0007007)	3.22082611
62	IMP metabolic process (GO:0046040)	3.20367320
63	ATP hydrolysis coupled proton transport (GO:0015991)	3.19251676
64	energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)	3.19251676
65	growth hormone secretion (GO:0030252)	3.18848521
66	fear response (GO:0042596)	3.17151871
67	protein localization to synapse (GO:0035418)	3.13202181
68	folic acid-containing compound metabolic process (GO:0006760)	3.11681049
69	serine family amino acid catabolic process (GO:0009071)	3.11677432
70	response to vitamin A (GO:0033189)	3.11150811
71	polyamine biosynthetic process (GO:0006596)	3.08489781
72	acrosome assembly (GO:0001675)	3.06405166
73	aminoglycoside antibiotic metabolic process (GO:0030647)	3.05986307
74	response to lipoprotein particle (GO:0055094)	3.05866168
75	regulation of endothelial cell differentiation (GO:0045601)	3.05343925
76	receptor guanylyl cyclase signaling pathway (GO:0007168)	3.01750069
77	protein targeting to vacuole (GO:0006623)	3.01487223
78	protein targeting to lysosome (GO:0006622)	3.01487223
79	establishment of protein localization to vacuole (GO:0072666)	3.01487223
80	rRNA methylation (GO:0031167)	2.98954398
81	postsynaptic membrane organization (GO:0001941)	2.98774444
82	negative regulation of telomerase activity (GO:0051974)	2.93944609
83	cartilage morphogenesis (GO:0060536)	2.91992107
84	glycoside metabolic process (GO:0016137)	2.91965428
85	gamma-aminobutyric acid transport (GO:0015812)	2.91020012
86	response to dietary excess (GO:0002021)	2.87291697
87	protein localization to lysosome (GO:0061462)	2.87191278
88	protein localization to vacuole (GO:0072665)	2.87191278
89	sulfur amino acid biosynthetic process (GO:0000097)	2.84884819
90	tetrahydrofolate metabolic process (GO:0046653)	2.83548419
91	positive regulation of action potential (GO:0045760)	2.79922764
92	neural crest cell development (GO:0014032)	2.78394310
93	positive regulation of mitochondrial fission (GO:0090141)	2.77897733
94	mRNA splice site selection (GO:0006376)	2.77214577
95	purine-containing compound salvage (GO:0043101)	2.76924181
96	auditory behavior (GO:0031223)	2.76882026
97	regulation of vitamin D biosynthetic process (GO:0060556)	2.75594794
98	tRNA processing (GO:0008033)	2.75461513
99	adult feeding behavior (GO:0008343)	2.75326092
100	synaptic transmission, cholinergic (GO:0007271)	2.75233678

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.63028660
2	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.21933168
3	VDR_22108803_ChIP-Seq_LS180_Human	3.12551332
4	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	2.91949411
5	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.89817648
6	ZNF274_21170338_ChIP-Seq_K562_Hela	2.28846120
7	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.25462938
8	REST_18959480_ChIP-ChIP_MESCs_Mouse	2.17499551
9	IGF1R_20145208_ChIP-Seq_DFB_Human	2.06755965
10	RNF2_27304074_Chip-Seq_NSC_Mouse	2.01270689
11	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	11.2310935
12	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.97163466
13	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.91551429
14	GBX2_23144817_ChIP-Seq_PC3_Human	1.91080593
15	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.76405240
16	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.75912296
17	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.73990987
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.69951073
19	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.64342158
20	POU5F1_18700969_ChIP-ChIP_MESCs_Mouse	1.64015463
21	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.61253241
22	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.60638282
23	REST_21632747_ChIP-Seq_MESCs_Mouse	1.58697168
24	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.56518741
25	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.53460396
26	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.52130039
27	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.51781441
28	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.46165420
29	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.45230468
30	ESR1_15608294_ChIP-ChIP_MCF-7_Human	1.42095753
31	TP53_22573176_ChIP-Seq_HFKS_Human	1.39753087
32	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.38216956
33	ELF1_17652178_ChIP-ChIP_JURKAT_Human	1.34142802
34	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.33165082
35	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.30787730
36	P300_19829295_ChIP-Seq_ESCs_Human	1.29447564
37	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.29230673
38	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.28751098
39	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.28751098
40	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25474914
41	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.24962132
42	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.23994604
43	FUS_26573619_Chip-Seq_HEK293_Human	1.23846014
44	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.22284488
45	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	1.20575255
46	E2F7_22180533_ChIP-Seq_HELA_Human	1.20226424
47	EWS_26573619_Chip-Seq_HEK293_Human	1.19073772
48	SOX2_22085726_ChIP-Seq_NPCs_Mouse	1.17704872
49	NCOR_22424771_ChIP-Seq_293T_Human	1.16578510
50	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.15280169
51	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.15073848
52	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.14060907
53	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.09906258
54	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.09191132
55	OCT4_20526341_ChIP-Seq_ESCs_Human	1.02938557
56	SOX9_26525672_Chip-Seq_Limbbuds_Mouse	1.02488710
57	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.01444263
58	BCAT_22108803_ChIP-Seq_LS180_Human	1.01070114
59	ETS1_20019798_ChIP-Seq_JURKAT_Human	0.99980831
60	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	0.99201100
61	SUZ12_27294783_Chip-Seq_ESCs_Mouse	0.98315396
62	GABP_19822575_ChIP-Seq_HepG2_Human	0.97997916
63	JARID2_20064375_ChIP-Seq_MESCs_Mouse	0.97874909
64	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.97473548
65	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	0.95366252
66	TAF2_19829295_ChIP-Seq_ESCs_Human	0.95164118
67	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.94013004
68	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	0.93790935
69	IRF1_19129219_ChIP-ChIP_H3396_Human	0.92434614
70	SALL1_21062744_ChIP-ChIP_HESCs_Human	0.90839478
71	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.89703639
72	JARID2_20075857_ChIP-Seq_MESCs_Mouse	0.89702297
73	SETDB1_19884257_ChIP-Seq_MESCs_Mouse	0.89130664
74	TAF15_26573619_Chip-Seq_HEK293_Human	0.87735557
75	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.86214570
76	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.86026592
77	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.85820871
78	XRN2_22483619_ChIP-Seq_HELA_Human	0.84911636
79	RUNX2_22187159_ChIP-Seq_PCA_Human	0.83905236
80	KLF5_20875108_ChIP-Seq_MESCs_Mouse	0.83639486
81	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	0.83411053
82	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.82856790
83	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.82748661
84	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	0.82631326
85	STAT3_23295773_ChIP-Seq_U87_Human	0.82183594
86	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.81050607
87	CDX2_22108803_ChIP-Seq_LS180_Human	0.77874574
88	JUN_21703547_ChIP-Seq_K562_Human	0.77800388
89	ETS1_21867929_ChIP-Seq_TH2_Mouse	0.77167728
90	FOXH1_21741376_ChIP-Seq_ESCs_Human	0.77093279
91	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.77058263
92	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	0.76887464
93	DNAJC2_21179169_ChIP-ChIP_NT2_Human	0.76587572
94	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.76466174
95	REST_19997604_ChIP-ChIP_NEURONS_Mouse	0.75369660
96	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.74946573
97	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	0.72810802
98	MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse	0.72462071
99	KDM2B_26808549_Chip-Seq_REH_Human	0.71708032
100	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	0.70951948

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003122_maternal_imprinting	4.61525850
2	MP0008995_early_reproductive_senescence	3.73183025
3	MP0005646_abnormal_pituitary_gland	3.65156297
4	MP0005360_urolithiasis	3.38622860
5	MP0002736_abnormal_nociception_after	3.04910214
6	MP0003183_abnormal_peptide_metabolism	2.84608325
7	MP0003121_genomic_imprinting	2.61049514
8	MP0006276_abnormal_autonomic_nervous	2.54014901
9	MP0008877_abnormal_DNA_methylation	2.47410194
10	MP0002938_white_spotting	2.44672455
11	MP0005670_abnormal_white_adipose	2.42463266
12	MP0003787_abnormal_imprinting	2.41959578
13	MP0004885_abnormal_endolymph	2.34631041
14	MP0000013_abnormal_adipose_tissue	2.18194993
15	MP0002102_abnormal_ear_morphology	2.13860602
16	MP0003011_delayed_dark_adaptation	2.13327229
17	MP0001502_abnormal_circadian_rhythm	2.12410781
18	MP0003880_abnormal_central_pattern	2.08005801
19	MP0001968_abnormal_touch/_nociception	2.02298204
20	MP0006072_abnormal_retinal_apoptosis	1.96628508
21	MP0001529_abnormal_vocalization	1.91772899
22	MP0004147_increased_porphyrin_level	1.90096063
23	MP0005551_abnormal_eye_electrophysiolog	1.87553340
24	MP0001764_abnormal_homeostasis	1.87366165
25	MP0001661_extended_life_span	1.84449380
26	MP0004133_heterotaxia	1.78510371
27	MP0002735_abnormal_chemical_nociception	1.77568395
28	MP0005253_abnormal_eye_physiology	1.76017806
29	MP0004859_abnormal_synaptic_plasticity	1.70075518
30	MP0000566_synostosis	1.63299129
31	MP0001486_abnormal_startle_reflex	1.54679393
32	MP0001188_hyperpigmentation	1.52532702
33	MP0002063_abnormal_learning/memory/cond	1.52049505
34	MP0003635_abnormal_synaptic_transmissio	1.45380485
35	MP0000631_abnormal_neuroendocrine_gland	1.45175885
36	MP0000516_abnormal_urinary_system	1.44629735
37	MP0005367_renal/urinary_system_phenotyp	1.44629735
38	MP0001440_abnormal_grooming_behavior	1.40775124
39	MP0002184_abnormal_innervation	1.38796295
40	MP0003890_abnormal_embryonic-extraembry	1.38746527
41	MP0000778_abnormal_nervous_system	1.38392162
42	MP0009745_abnormal_behavioral_response	1.34151738
43	MP0005423_abnormal_somatic_nervous	1.26691353
44	MP0002272_abnormal_nervous_system	1.25866468
45	MP0009046_muscle_twitch	1.22900153
46	MP0002069_abnormal_eating/drinking_beha	1.22435412
47	MP0001984_abnormal_olfaction	1.21462441
48	MP0009697_abnormal_copulation	1.19832897
49	MP0008872_abnormal_physiological_respon	1.18995515
50	MP0002822_catalepsy	1.18258480
51	MP0000026_abnormal_inner_ear	1.18105798
52	MP0003705_abnormal_hypodermis_morpholog	1.18031035
53	MP0005645_abnormal_hypothalamus_physiol	1.15494690
54	MP0005394_taste/olfaction_phenotype	1.14770230
55	MP0005499_abnormal_olfactory_system	1.14770230
56	MP0000534_abnormal_ureter_morphology	1.11432405
57	MP0005171_absent_coat_pigmentation	1.10691076
58	MP0005332_abnormal_amino_acid	1.09474408
59	MP0003186_abnormal_redox_activity	1.09397750
60	MP0002572_abnormal_emotion/affect_behav	1.04904947
61	MP0001905_abnormal_dopamine_level	1.03263782
62	MP0002734_abnormal_mechanical_nocicepti	1.02920582
63	MP0004142_abnormal_muscle_tone	1.00840875
64	MP0000647_abnormal_sebaceous_gland	0.99587532
65	MP0003878_abnormal_ear_physiology	0.99209259
66	MP0005377_hearing/vestibular/ear_phenot	0.99209259
67	MP0002396_abnormal_hematopoietic_system	0.96908448
68	MP0000955_abnormal_spinal_cord	0.96331340
69	MP0002697_abnormal_eye_size	0.94800927
70	MP0002064_seizures	0.94773209
71	MP0002210_abnormal_sex_determination	0.94310806
72	MP0002876_abnormal_thyroid_physiology	0.92585468
73	MP0002095_abnormal_skin_pigmentation	0.90751513
74	MP0002557_abnormal_social/conspecific_i	0.88019858
75	MP0004043_abnormal_pH_regulation	0.87708425
76	MP0003567_abnormal_fetal_cardiomyocyte	0.85436414
77	MP0004811_abnormal_neuron_physiology	0.84924835
78	MP0002295_abnormal_pulmonary_circulatio	0.83597972
79	MP0005410_abnormal_fertilization	0.83430675
80	MP0002067_abnormal_sensory_capabilities	0.83408201
81	MP0003786_premature_aging	0.83404462
82	MP0001963_abnormal_hearing_physiology	0.82056709
83	MP0002882_abnormal_neuron_morphology	0.81049628
84	MP0002733_abnormal_thermal_nociception	0.80839709
85	MP0000653_abnormal_sex_gland	0.80751968
86	MP0006292_abnormal_olfactory_placode	0.80725830
87	MP0002752_abnormal_somatic_nervous	0.80718176
88	MP0002066_abnormal_motor_capabilities/c	0.79408061
89	MP0002909_abnormal_adrenal_gland	0.79362883
90	MP0003698_abnormal_male_reproductive	0.77356883
91	MP0001485_abnormal_pinna_reflex	0.77041852
92	MP0008789_abnormal_olfactory_epithelium	0.76693215
93	MP0001145_abnormal_male_reproductive	0.71896540
94	MP0005195_abnormal_posterior_eye	0.71026675
95	MP0003724_increased_susceptibility_to	0.69314159
96	MP0005391_vision/eye_phenotype	0.69137466
97	MP0002152_abnormal_brain_morphology	0.68612199
98	MP0001970_abnormal_pain_threshold	0.68504978
99	MP0002229_neurodegeneration	0.68061344
100	MP0002837_dystrophic_cardiac_calcinosis	0.67731837

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of alanine metabolism (HP:0010916)	7.54711203
2	Hyperalaninemia (HP:0003348)	7.54711203
3	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	7.54711203
4	Pendular nystagmus (HP:0012043)	4.76316249
5	Constricted visual fields (HP:0001133)	4.71184626
6	Congenital sensorineural hearing impairment (HP:0008527)	4.71090303
7	Oligomenorrhea (HP:0000876)	4.66209637
8	Spontaneous hematomas (HP:0007420)	4.59094619
9	White forelock (HP:0002211)	4.36008236
10	Abnormality of the labia minora (HP:0012880)	4.11845148
11	Patchy hypopigmentation of hair (HP:0011365)	4.00704763
12	Esophageal varix (HP:0002040)	3.74053378
13	Birth length less than 3rd percentile (HP:0003561)	3.64150549
14	Abnormality of homocysteine metabolism (HP:0010919)	3.59195341
15	Homocystinuria (HP:0002156)	3.59195341
16	Abnormal umbilical cord blood vessels (HP:0011403)	3.55935580
17	Single umbilical artery (HP:0001195)	3.55935580
18	Abnormality of the fetal cardiovascular system (HP:0010948)	3.55935580
19	Decreased electroretinogram (ERG) amplitude (HP:0000654)	3.44398445
20	Chronic hepatic failure (HP:0100626)	3.43252014
21	Action tremor (HP:0002345)	3.23125901
22	Polyphagia (HP:0002591)	3.23062820
23	Poor speech (HP:0002465)	3.22833116
24	Abnormality of serum amino acid levels (HP:0003112)	3.17895552
25	Heterochromia iridis (HP:0001100)	3.07881401
26	Generalized aminoaciduria (HP:0002909)	2.84521677
27	Cortical visual impairment (HP:0100704)	2.72226406
28	Maternal diabetes (HP:0009800)	2.67293292
29	Conjunctival telangiectasia (HP:0000524)	2.64630520
30	Fatigue (HP:0012378)	2.63730638
31	Abnormality of sulfur amino acid metabolism (HP:0004339)	2.61483757
32	Conjugated hyperbilirubinemia (HP:0002908)	2.60752755
33	Impaired vibration sensation in the lower limbs (HP:0002166)	2.57739810
34	Carpal bone hypoplasia (HP:0001498)	2.57288740
35	Atonic seizures (HP:0010819)	2.54617633
36	Abnormality of the corticospinal tract (HP:0002492)	2.54472608
37	Abolished electroretinogram (ERG) (HP:0000550)	2.49196532
38	Hypoalphalipoproteinemia (HP:0003233)	2.48935642
39	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	2.48171766
40	Failure to thrive in infancy (HP:0001531)	2.46410319
41	Anorexia (HP:0002039)	2.44582670
42	Hypomagnesemia (HP:0002917)	2.35611428
43	Degeneration of the lateral corticospinal tracts (HP:0002314)	2.30548873
44	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	2.30548873
45	Myocardial infarction (HP:0001658)	2.21572407
46	Abnormal respiratory epithelium morphology (HP:0012253)	2.16467176
47	Abnormal respiratory motile cilium morphology (HP:0005938)	2.16467176
48	Focal motor seizures (HP:0011153)	2.13737264
49	Pigmentary retinal degeneration (HP:0001146)	2.12085768
50	Attenuation of retinal blood vessels (HP:0007843)	2.11155791
51	Visceral angiomatosis (HP:0100761)	2.09636326
52	Short tibia (HP:0005736)	2.09603317
53	Hyperglycinemia (HP:0002154)	2.07936753
54	Abnormality of the vasculature of the conjunctiva (HP:0008054)	2.05566229
55	Esotropia (HP:0000565)	2.05532954
56	Cortical dysplasia (HP:0002539)	2.03041951
57	Aplasia/Hypoplasia involving the carpal bones (HP:0006502)	2.02479757
58	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	1.99418672
59	Pulmonary embolism (HP:0002204)	1.98535745
60	Hypoplastic left heart (HP:0004383)	1.98359967
61	Symptomatic seizures (HP:0011145)	1.93782194
62	Chorioretinal atrophy (HP:0000533)	1.93623915
63	Insulin-resistant diabetes mellitus (HP:0000831)	1.93001143
64	Abnormality of the umbilical cord (HP:0010881)	1.92424130
65	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.92001530
66	3-Methylglutaconic aciduria (HP:0003535)	1.89327862
67	Abnormal hair whorl (HP:0010721)	1.83859935
68	Lissencephaly (HP:0001339)	1.82170503
69	Hemangiomatosis (HP:0007461)	1.81816767
70	Cone-rod dystrophy (HP:0000548)	1.81743209
71	Increased serum lactate (HP:0002151)	1.80750933
72	Arteriovenous malformation (HP:0100026)	1.79612774
73	Toxemia of pregnancy (HP:0100603)	1.77785430
74	Type II diabetes mellitus (HP:0005978)	1.77160181
75	Epidermoid cyst (HP:0200040)	1.77094104
76	Labial hypoplasia (HP:0000066)	1.76478878
77	Abnormality of the lower motor neuron (HP:0002366)	1.75122517
78	Hip dysplasia (HP:0001385)	1.74350297
79	Chronic otitis media (HP:0000389)	1.72663359
80	Poor suck (HP:0002033)	1.71249970
81	Abnormal tarsal ossification (HP:0008369)	1.71032832
82	Ankle clonus (HP:0011448)	1.68109201
83	Clonus (HP:0002169)	1.67926717
84	Absent septum pellucidum (HP:0001331)	1.67332134
85	Decreased muscle mass (HP:0003199)	1.66424846
86	Abnormality of magnesium homeostasis (HP:0004921)	1.65943288
87	Oligodactyly (hands) (HP:0001180)	1.65531600
88	Absence seizures (HP:0002121)	1.63970328
89	Hypoplastic female external genitalia (HP:0012815)	1.63336760
90	Anencephaly (HP:0002323)	1.61194358
91	Complete atrioventricular canal defect (HP:0001674)	1.61102097
92	Megaloblastic anemia (HP:0001889)	1.60451830
93	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.60203708
94	Hypoplasia of the brainstem (HP:0002365)	1.60203708
95	Sleep apnea (HP:0010535)	1.58182024
96	Urinary bladder sphincter dysfunction (HP:0002839)	1.58134579
97	Severe Myopia (HP:0011003)	1.57948853
98	Abnormality of the phalanges of the hallux (HP:0010057)	1.57767732
99	Lactic acidosis (HP:0003128)	1.56386115
100	Focal seizures (HP:0007359)	1.56344001

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NTRK3	3.08225920
2	MAP3K3	3.08172076
3	DYRK2	3.00405514
4	FGR	2.96134501
5	MARK1	2.73426839
6	NTRK2	2.72622887
7	MAP2K3	2.64269544
8	BCR	2.48214838
9	ACVR1B	2.46723127
10	PINK1	2.38156691
11	UHMK1	2.33123189
12	JAK3	2.26702795
13	SGK223	2.10013883
14	SGK494	2.10013883
15	MAP2K7	2.08058039
16	EPHB2	1.98672114
17	MAP3K11	1.95526232
18	LMTK2	1.85481974
19	TRIM28	1.84739005
20	CDK9	1.81237133
21	PAK3	1.70775556
22	MAP3K4	1.67937997
23	MINK1	1.55099893
24	SGK2	1.54600439
25	CASK	1.51322537
26	MAP4K2	1.37117477
27	BUB1	1.36287290
28	CCNB1	1.35127632
29	EPHA3	1.33080866
30	SIK3	1.26159495
31	RPS6KB2	1.20408024
32	CSNK1G2	1.18628877
33	CSNK1G3	1.16184406
34	WNK3	1.13956095
35	CSNK1A1	1.11018853
36	MAP2K4	1.08167198
37	CDK5	1.04792514
38	STK16	1.04184690
39	CSNK1G1	1.00456646
40	EPHA4	1.00435079
41	TYRO3	0.98694998
42	AURKA	0.98606927
43	NUAK1	0.97459008
44	PRKCE	0.94139518
45	PHKG2	0.91097431
46	PHKG1	0.91097431
47	DYRK3	0.89657226
48	PRKCG	0.89592570
49	DAPK2	0.89007171
50	PLK2	0.88275582
51	OXSR1	0.88034933
52	MAPK13	0.87151331
53	DYRK1B	0.84020074
54	NEK6	0.80928400
55	MAP3K12	0.80301533
56	EPHB1	0.78743895
57	CSNK1A1L	0.78742336
58	CAMK1	0.78617678
59	MAP3K6	0.78365944
60	RPS6KA5	0.78335421
61	PRKCI	0.77487694
62	MAP2K1	0.74344521
63	ADRBK1	0.73883930
64	SGK1	0.72292025
65	VRK1	0.72140832
66	PAK6	0.72110729
67	PKN1	0.70782005
68	SGK3	0.70351418
69	PRKCQ	0.66422005
70	RPS6KB1	0.65907250
71	CAMK2B	0.64178023
72	EIF2AK3	0.62797587
73	DYRK1A	0.59344552
74	MAP3K5	0.57602116
75	MAPKAPK5	0.54029067
76	MATK	0.50619794
77	CDK14	0.50309964
78	CDK18	0.48290590
79	DMPK	0.48195435
80	RAF1	0.47818141
81	PIK3CA	0.45891482
82	IRAK1	0.44427526
83	VRK2	0.42976585
84	CAMK2A	0.42566923
85	EGFR	0.42383679
86	CDK15	0.42193207
87	SIK2	0.40739191
88	CDK11A	0.39173926
89	CHEK2	0.38803823
90	PRKCA	0.35721638
91	CDK19	0.35202735
92	MAPK9	0.32793827
93	PNCK	0.32497423
94	INSR	0.32210872
95	RPS6KA1	0.31791010
96	PRKCD	0.31451367
97	FES	0.29136582
98	BMPR1B	0.29060962
99	PRKACA	0.28405349
100	CDC7	0.27242592

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Arginine biosynthesis_Homo sapiens_hsa00220	3.52476215
2	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	3.40251380
3	Sulfur metabolism_Homo sapiens_hsa00920	3.27240294
4	Nicotine addiction_Homo sapiens_hsa05033	3.15142965
5	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.90819703
6	Collecting duct acid secretion_Homo sapiens_hsa04966	2.74087916
7	GABAergic synapse_Homo sapiens_hsa04727	2.71045484
8	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.69748485
9	One carbon pool by folate_Homo sapiens_hsa00670	2.69712711
10	Sulfur relay system_Homo sapiens_hsa04122	2.46577421
11	Morphine addiction_Homo sapiens_hsa05032	2.37205209
12	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	2.26371964
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	2.21862249
14	Selenocompound metabolism_Homo sapiens_hsa00450	2.15371213
15	Butanoate metabolism_Homo sapiens_hsa00650	1.97064862
16	Oxidative phosphorylation_Homo sapiens_hsa00190	1.95244533
17	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.87376777
18	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.86579662
19	Dopaminergic synapse_Homo sapiens_hsa04728	1.81152655
20	Alcoholism_Homo sapiens_hsa05034	1.72452555
21	Galactose metabolism_Homo sapiens_hsa00052	1.58952003
22	Glutamatergic synapse_Homo sapiens_hsa04724	1.50313731
23	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.49565646
24	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.47855427
25	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	1.46628032
26	mRNA surveillance pathway_Homo sapiens_hsa03015	1.46291844
27	Vibrio cholerae infection_Homo sapiens_hsa05110	1.46097871
28	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.43719796
29	Steroid biosynthesis_Homo sapiens_hsa00100	1.42960451
30	Parkinsons disease_Homo sapiens_hsa05012	1.39815566
31	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.39413406
32	Serotonergic synapse_Homo sapiens_hsa04726	1.39275988
33	Circadian entrainment_Homo sapiens_hsa04713	1.27059901
34	Retinol metabolism_Homo sapiens_hsa00830	1.25981146
35	Taste transduction_Homo sapiens_hsa04742	1.19358649
36	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.19077615
37	Arginine and proline metabolism_Homo sapiens_hsa00330	1.12016552
38	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	1.10633150
39	Phototransduction_Homo sapiens_hsa04744	1.10013293
40	Huntingtons disease_Homo sapiens_hsa05016	1.06483315
41	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.03390112
42	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.03133460
43	Proteasome_Homo sapiens_hsa03050	1.02441635
44	Regulation of autophagy_Homo sapiens_hsa04140	0.99119041
45	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.92674612
46	Cholinergic synapse_Homo sapiens_hsa04725	0.89239326
47	Ether lipid metabolism_Homo sapiens_hsa00565	0.88815597
48	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.87512842
49	Cocaine addiction_Homo sapiens_hsa05030	0.82760443
50	Olfactory transduction_Homo sapiens_hsa04740	0.81561096
51	Basal transcription factors_Homo sapiens_hsa03022	0.78629649
52	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.77756741
53	Peroxisome_Homo sapiens_hsa04146	0.77179531
54	Nitrogen metabolism_Homo sapiens_hsa00910	0.75518491
55	Linoleic acid metabolism_Homo sapiens_hsa00591	0.73589267
56	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.73303670
57	Alzheimers disease_Homo sapiens_hsa05010	0.72002071
58	Fatty acid elongation_Homo sapiens_hsa00062	0.70757601
59	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.70613306
60	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.70337206
61	RNA degradation_Homo sapiens_hsa03018	0.69998827
62	Protein export_Homo sapiens_hsa03060	0.66647182
63	Fat digestion and absorption_Homo sapiens_hsa04975	0.65797597
64	RNA transport_Homo sapiens_hsa03013	0.64890978
65	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.64044316
66	Homologous recombination_Homo sapiens_hsa03440	0.61442130
67	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.59904055
68	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.58141794
69	Amphetamine addiction_Homo sapiens_hsa05031	0.57615436
70	Metabolic pathways_Homo sapiens_hsa01100	0.57104977
71	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.54393947
72	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.54073947
73	Spliceosome_Homo sapiens_hsa03040	0.53921730
74	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.53505749
75	Cardiac muscle contraction_Homo sapiens_hsa04260	0.52876002
76	Fanconi anemia pathway_Homo sapiens_hsa03460	0.51642053
77	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.49472774
78	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.44065720
79	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.44042738
80	Base excision repair_Homo sapiens_hsa03410	0.43660989
81	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.43163011
82	Tryptophan metabolism_Homo sapiens_hsa00380	0.41897065
83	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40841419
84	Phenylalanine metabolism_Homo sapiens_hsa00360	0.37994787
85	RNA polymerase_Homo sapiens_hsa03020	0.36701302
86	Tyrosine metabolism_Homo sapiens_hsa00350	0.33512113
87	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32317743
88	beta-Alanine metabolism_Homo sapiens_hsa00410	0.32308761
89	ABC transporters_Homo sapiens_hsa02010	0.31765228
90	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.30171490
91	Carbon metabolism_Homo sapiens_hsa01200	0.29670154
92	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.28015871
93	Insulin secretion_Homo sapiens_hsa04911	0.26803910
94	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.25127608
95	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.23771123
96	Oocyte meiosis_Homo sapiens_hsa04114	0.22078428
97	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.20565340
98	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.20330451
99	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.19626933
100	Folate biosynthesis_Homo sapiens_hsa00790	0.17504872

CXADRP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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