ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	synaptonemal complex assembly (GO:0007130)	9.50071717
2	male meiosis I (GO:0007141)	8.64383043
3	piRNA metabolic process (GO:0034587)	8.46031692
4	synaptonemal complex organization (GO:0070193)	8.45027105
5	meiosis I (GO:0007127)	7.57363398
6	male meiosis (GO:0007140)	7.51609959
7	DNA synthesis involved in DNA repair (GO:0000731)	6.96866544
8	DNA methylation involved in gamete generation (GO:0043046)	6.68726062
9	meiotic nuclear division (GO:0007126)	6.66220698
10	meiotic cell cycle process (GO:1903046)	5.87237183
11	meiotic chromosome segregation (GO:0045132)	5.45011149
12	regulation of meiosis I (GO:0060631)	5.39513003
13	reciprocal meiotic recombination (GO:0007131)	5.37296810
14	reciprocal DNA recombination (GO:0035825)	5.37296810
15	resolution of meiotic recombination intermediates (GO:0000712)	5.01661149
16	histone H4-K12 acetylation (GO:0043983)	4.59904422
17	sister chromatid cohesion (GO:0007062)	4.19850719
18	sperm motility (GO:0030317)	4.03714802
19	spermatid development (GO:0007286)	3.72521950
20	musculoskeletal movement (GO:0050881)	3.60156487
21	multicellular organismal movement (GO:0050879)	3.60156487
22	gene silencing by RNA (GO:0031047)	3.60033626
23	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.56127313
24	negative regulation of sodium ion transport (GO:0010766)	3.55933461
25	histone exchange (GO:0043486)	3.48412696
26	DNA packaging (GO:0006323)	3.43616770
27	intraciliary transport (GO:0042073)	3.42050637
28	regulation of transcription from RNA polymerase I promoter (GO:0006356)	3.29230034
29	sperm-egg recognition (GO:0035036)	3.27925123
30	spinal cord association neuron differentiation (GO:0021527)	3.27324229
31	reproductive system development (GO:0061458)	3.21395518
32	cilium or flagellum-dependent cell motility (GO:0001539)	3.19635649
33	ATP synthesis coupled proton transport (GO:0015986)	3.17534755
34	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.17534755
35	histone H3-K9 demethylation (GO:0033169)	3.16255380
36	fertilization (GO:0009566)	3.16042780
37	positive regulation of response to oxidative stress (GO:1902884)	3.11176873
38	positive regulation of cellular response to oxidative stress (GO:1900409)	3.11176873
39	male gamete generation (GO:0048232)	3.02461560
40	proteasome assembly (GO:0043248)	3.01802692
41	spermatogenesis (GO:0007283)	3.01445143
42	regulation of cilium movement (GO:0003352)	3.01406073
43	multicellular organism reproduction (GO:0032504)	2.99888658
44	centriole replication (GO:0007099)	2.99745459
45	protein polyglutamylation (GO:0018095)	2.98305890
46	acrosome assembly (GO:0001675)	2.97141797
47	endosome to pigment granule transport (GO:0043485)	2.95443073
48	endosome to melanosome transport (GO:0035646)	2.95443073
49	negative regulation of gene silencing (GO:0060969)	2.92641550
50	gamete generation (GO:0007276)	2.91805623
51	chromosome condensation (GO:0030261)	2.91407050
52	positive regulation of meiosis (GO:0045836)	2.91156257
53	regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)	2.88670886
54	regulation of dopamine uptake involved in synaptic transmission (GO:0051584)	2.88670886
55	interkinetic nuclear migration (GO:0022027)	2.87424248
56	tRNA methylation (GO:0030488)	2.87243494
57	negative regulation of sister chromatid segregation (GO:0033046)	2.85057708
58	negative regulation of mitotic metaphase/anaphase transition (GO:0045841)	2.85057708
59	negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)	2.85057708
60	negative regulation of mitotic sister chromatid segregation (GO:0033048)	2.85057708
61	negative regulation of mitotic sister chromatid separation (GO:2000816)	2.85057708
62	mitotic spindle checkpoint (GO:0071174)	2.82743596
63	protein localization to cilium (GO:0061512)	2.81462230
64	female gamete generation (GO:0007292)	2.80610860
65	mitotic spindle assembly checkpoint (GO:0007094)	2.78341702
66	microtubule depolymerization (GO:0007019)	2.76072981
67	negative regulation of chromosome segregation (GO:0051985)	2.73604373
68	behavioral response to cocaine (GO:0048148)	2.71938245
69	spindle assembly checkpoint (GO:0071173)	2.70430038
70	regulation of gene silencing by RNA (GO:0060966)	2.70078206
71	regulation of posttranscriptional gene silencing (GO:0060147)	2.70078206
72	regulation of gene silencing by miRNA (GO:0060964)	2.70078206
73	DNA replication checkpoint (GO:0000076)	2.70075242
74	positive regulation of meiotic cell cycle (GO:0051446)	2.69636837
75	chromosome organization (GO:0051276)	2.69357024
76	embryonic body morphogenesis (GO:0010172)	2.66343060
77	microtubule polymerization or depolymerization (GO:0031109)	2.66069909
78	regulation of meiotic cell cycle (GO:0051445)	2.65648304
79	pantothenate metabolic process (GO:0015939)	2.61394043
80	regulation of histone H3-K9 methylation (GO:0051570)	2.61313548
81	peristalsis (GO:0030432)	2.60804742
82	regulation of microtubule-based movement (GO:0060632)	2.60648602
83	serotonin metabolic process (GO:0042428)	2.58912295
84	polyamine biosynthetic process (GO:0006596)	2.58452007
85	CENP-A containing nucleosome assembly (GO:0034080)	2.58141151
86	spindle checkpoint (GO:0031577)	2.54868198
87	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	2.53935351
88	cell-cell recognition (GO:0009988)	2.53437054
89	binding of sperm to zona pellucida (GO:0007339)	2.53110987
90	retinal cone cell development (GO:0046549)	2.51674353
91	nonmotile primary cilium assembly (GO:0035058)	2.51250443
92	epithelial cilium movement (GO:0003351)	2.49499018
93	meiotic cell cycle (GO:0051321)	2.49030116
94	chromatin remodeling at centromere (GO:0031055)	2.47092111
95	primary amino compound metabolic process (GO:1901160)	2.47087687
96	transmission of nerve impulse (GO:0019226)	2.46057292
97	DNA alkylation (GO:0006305)	2.45713284
98	DNA methylation (GO:0006306)	2.45713284
99	synapsis (GO:0007129)	10.8609187
100	chromosome organization involved in meiosis (GO:0070192)	10.0464282

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	3.95929893
2	ZNF274_21170338_ChIP-Seq_K562_Hela	3.13243820
3	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	3.03435768
4	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	2.94829122
5	VDR_22108803_ChIP-Seq_LS180_Human	2.94796096
6	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.76681605
7	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	2.59027526
8	IGF1R_20145208_ChIP-Seq_DFB_Human	2.54808706
9	FOXM1_23109430_ChIP-Seq_U2OS_Human	2.46380024
10	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.29706279
11	EWS_26573619_Chip-Seq_HEK293_Human	2.26658410
12	FUS_26573619_Chip-Seq_HEK293_Human	2.23865834
13	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.20820085
14	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.09753548
15	E2F7_22180533_ChIP-Seq_HELA_Human	1.96255535
16	TAF15_26573619_Chip-Seq_HEK293_Human	1.95094306
17	ER_23166858_ChIP-Seq_MCF-7_Human	1.93706618
18	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.91129267
19	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.89497502
20	GBX2_23144817_ChIP-Seq_PC3_Human	1.83092122
21	E2F4_17652178_ChIP-ChIP_JURKAT_Human	1.83065385
22	RNF2_27304074_Chip-Seq_NSC_Mouse	1.81631000
23	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.80119768
24	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.72904488
25	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.72904488
26	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.72812557
27	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.71796720
28	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.70569012
29	BCAT_22108803_ChIP-Seq_LS180_Human	1.69891590
30	P300_19829295_ChIP-Seq_ESCs_Human	1.66423051
31	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.62756806
32	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.61452075
33	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.56005912
34	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.55905652
35	AR_21572438_ChIP-Seq_LNCaP_Human	1.55455960
36	STAT3_23295773_ChIP-Seq_U87_Human	1.45485943
37	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.43090000
38	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.41908551
39	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.38138115
40	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.36192718
41	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.35471498
42	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.35471498
43	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.35303360
44	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.34222464
45	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.33685993
46	TP53_22573176_ChIP-Seq_HFKS_Human	1.32070905
47	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.31291948
48	AR_25329375_ChIP-Seq_VCAP_Human	1.30155267
49	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.29940762
50	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.29255318
51	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.28377017
52	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.28329090
53	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.27901126
54	MYC_18940864_ChIP-ChIP_HL60_Human	1.26728028
55	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.26661002
56	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.26133102
57	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.25641867
58	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22918202
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.20928859
60	WDR5_24793694_ChIP-Seq_LNCAP_Human	1.19951218
61	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.18777367
62	MYC_19829295_ChIP-Seq_ESCs_Human	1.14887935
63	MYC_18555785_ChIP-Seq_MESCs_Mouse	1.13518362
64	TCF4_23295773_ChIP-Seq_U87_Human	1.13371134
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.12015106
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.12015106
67	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.11536052
68	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.10822587
69	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	1.09682195
70	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.09599329
71	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.08995540
72	ETV1_20927104_ChIP-Seq_GIST48_Human	1.07751200
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.06461278
74	CBX2_22325352_ChIP-Seq_293T-Rex_Human	1.06213426
75	RBPJ_21746931_ChIP-Seq_IB4_Human	1.06139443
76	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.05242925
77	AUTS2_25519132_ChIP-Seq_293T-REX_Human	1.05075054
78	PADI4_21655091_ChIP-ChIP_MCF-7_Human	1.04586689
79	TCF4_22108803_ChIP-Seq_LS180_Human	1.04234078
80	HOXB7_26014856_ChIP-Seq_BT474_Human	1.00222349
81	AR_20517297_ChIP-Seq_VCAP_Human	1.00018199
82	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.99784939
83	NCOR_22424771_ChIP-Seq_293T_Human	0.99557306
84	CREB1_15753290_ChIP-ChIP_HEK293T_Human	0.99154465
85	E2F1_21310950_ChIP-Seq_MCF-7_Human	0.98275318
86	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	0.97537072
87	DCP1A_22483619_ChIP-Seq_HELA_Human	0.97217313
88	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.96911007
89	CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.96787950
90	NR3C1_21868756_ChIP-Seq_MCF10A_Human	0.96766387
91	PCGF4_22325352_ChIP-Seq_293T-Rex_Human	0.96636062
92	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	0.96513812
93	REST_21632747_ChIP-Seq_MESCs_Mouse	0.96002953
94	TTF2_22483619_ChIP-Seq_HELA_Human	0.95957865
95	OCT1_27270436_Chip-Seq_PROSTATE_Human	0.95579398
96	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93412095
97	EBNA1_20929547_Chip-Seq_RAJI-cells_Human	0.92758864
98	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	0.91278567
99	YY1_21170310_ChIP-Seq_MESCs_Mouse	0.91151251
100	RUNX1_26923725_Chip-Seq_HPCs_Mouse	0.89738798

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0008877_abnormal_DNA_methylation	5.88535422
2	MP0002210_abnormal_sex_determination	3.33334367
3	MP0001929_abnormal_gametogenesis	3.28610962
4	MP0005410_abnormal_fertilization	3.16952983
5	MP0003698_abnormal_male_reproductive	3.09591296
6	MP0001485_abnormal_pinna_reflex	2.82925246
7	MP0000569_abnormal_digit_pigmentation	2.75168042
8	MP0008058_abnormal_DNA_repair	2.74656505
9	MP0005171_absent_coat_pigmentation	2.70415876
10	MP0001145_abnormal_male_reproductive	2.61390380
11	MP0000566_synostosis	2.55389816
12	MP0006276_abnormal_autonomic_nervous	2.40680516
13	MP0000653_abnormal_sex_gland	2.39323808
14	MP0008007_abnormal_cellular_replicative	2.31170209
15	MP0009046_muscle_twitch	2.15853496
16	MP0003646_muscle_fatigue	2.00583981
17	MP0003136_yellow_coat_color	1.92461097
18	MP0002160_abnormal_reproductive_system	1.86161496
19	MP0006292_abnormal_olfactory_placode	1.82672072
20	MP0002161_abnormal_fertility/fecundity	1.79337719
21	MP0003718_maternal_effect	1.78141280
22	MP0005551_abnormal_eye_electrophysiolog	1.68149866
23	MP0002938_white_spotting	1.65670231
24	MP0008995_early_reproductive_senescence	1.60615343
25	MP0001486_abnormal_startle_reflex	1.60292533
26	MP0010094_abnormal_chromosome_stability	1.57491349
27	MP0009379_abnormal_foot_pigmentation	1.56259859
28	MP0010030_abnormal_orbit_morphology	1.54548168
29	MP0005451_abnormal_body_composition	1.51806116
30	MP0000427_abnormal_hair_cycle	1.51714261
31	MP0005670_abnormal_white_adipose	1.50135557
32	MP0005174_abnormal_tail_pigmentation	1.48120128
33	MP0005167_abnormal_blood-brain_barrier	1.46600284
34	MP0004885_abnormal_endolymph	1.41582073
35	MP0005389_reproductive_system_phenotype	1.39757976
36	MP0002638_abnormal_pupillary_reflex	1.35975203
37	MP0000678_abnormal_parathyroid_gland	1.32620124
38	MP0002653_abnormal_ependyma_morphology	1.27954165
39	MP0005377_hearing/vestibular/ear_phenot	1.27296381
40	MP0003878_abnormal_ear_physiology	1.27296381
41	MP0001968_abnormal_touch/_nociception	1.25803415
42	MP0003183_abnormal_peptide_metabolism	1.20176062
43	MP0002735_abnormal_chemical_nociception	1.19556851
44	MP0008872_abnormal_physiological_respon	1.18317083
45	MP0008004_abnormal_stomach_pH	1.17447567
46	MP0000631_abnormal_neuroendocrine_gland	1.17060952
47	MP0001119_abnormal_female_reproductive	1.15648053
48	MP0003937_abnormal_limbs/digits/tail_de	1.13702705
49	MP0004742_abnormal_vestibular_system	1.11835961
50	MP0008789_abnormal_olfactory_epithelium	1.09877651
51	MP0009745_abnormal_behavioral_response	1.09357139
52	MP0003111_abnormal_nucleus_morphology	1.08456355
53	MP0003699_abnormal_female_reproductive	1.08356766
54	MP0000579_abnormal_nail_morphology	1.07601646
55	MP0002067_abnormal_sensory_capabilities	1.06772046
56	MP0003938_abnormal_ear_development	1.06674899
57	MP0005253_abnormal_eye_physiology	1.05007289
58	MP0000230_abnormal_systemic_arterial	1.03042486
59	MP0002736_abnormal_nociception_after	1.02105805
60	MP0001188_hyperpigmentation	1.01725691
61	MP0002095_abnormal_skin_pigmentation	1.01084823
62	MP0002089_abnormal_postnatal_growth/wei	0.99161408
63	MP0000537_abnormal_urethra_morphology	0.98963057
64	MP0003693_abnormal_embryo_hatching	0.98873956
65	MP0003119_abnormal_digestive_system	0.98521513
66	MP0000778_abnormal_nervous_system	0.94107551
67	MP0004142_abnormal_muscle_tone	0.92785703
68	MP0003077_abnormal_cell_cycle	0.91567537
69	MP0003638_abnormal_response/metabolism_	0.90068810
70	MP0002557_abnormal_social/conspecific_i	0.89670646
71	MP0001919_abnormal_reproductive_system	0.87844427
72	MP0001324_abnormal_eye_pigmentation	0.87758865
73	MP0001986_abnormal_taste_sensitivity	0.86604604
74	MP0002734_abnormal_mechanical_nocicepti	0.86576063
75	MP0000751_myopathy	0.85728056
76	MP0002282_abnormal_trachea_morphology	0.81779305
77	MP0002572_abnormal_emotion/affect_behav	0.80795132
78	MP0000372_irregular_coat_pigmentation	0.79160089
79	MP0000647_abnormal_sebaceous_gland	0.78663651
80	MP0001293_anophthalmia	0.78312284
81	MP0000026_abnormal_inner_ear	0.77358610
82	MP0000955_abnormal_spinal_cord	0.76981979
83	MP0002272_abnormal_nervous_system	0.76907317
84	MP0004215_abnormal_myocardial_fiber	0.76178336
85	MP0001440_abnormal_grooming_behavior	0.75393974
86	MP0001963_abnormal_hearing_physiology	0.75322541
87	MP0000049_abnormal_middle_ear	0.74436368
88	MP0005310_abnormal_salivary_gland	0.74360388
89	MP0002184_abnormal_innervation	0.72829635
90	MP0001529_abnormal_vocalization	0.71377077
91	MP0000383_abnormal_hair_follicle	0.71360301
92	MP0002108_abnormal_muscle_morphology	0.70050767
93	MP0005499_abnormal_olfactory_system	0.69560245
94	MP0005394_taste/olfaction_phenotype	0.69560245
95	MP0005195_abnormal_posterior_eye	0.68683949
96	MP0003137_abnormal_impulse_conducting	0.68652123
97	MP0003861_abnormal_nervous_system	0.68341628
98	MP0001970_abnormal_pain_threshold	0.68177162
99	MP0003936_abnormal_reproductive_system	0.67066274
100	MP0004957_abnormal_blastocyst_morpholog	0.65060378

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Broad distal phalanx of finger (HP:0009836)	5.33210556
2	Short nail (HP:0001799)	4.25990256
3	Nephronophthisis (HP:0000090)	3.86234703
4	Type II lissencephaly (HP:0007260)	3.80473408
5	Abnormality of cochlea (HP:0000375)	3.79289541
6	11 pairs of ribs (HP:0000878)	3.71777696
7	Tubulointerstitial nephritis (HP:0001970)	3.68250186
8	Abnormality of midbrain morphology (HP:0002418)	3.48127273
9	Molar tooth sign on MRI (HP:0002419)	3.48127273
10	Morphological abnormality of the inner ear (HP:0011390)	3.37262067
11	Congenital stationary night blindness (HP:0007642)	3.29181700
12	Optic nerve hypoplasia (HP:0000609)	3.19056236
13	Abnormality of the renal medulla (HP:0100957)	3.08753166
14	True hermaphroditism (HP:0010459)	3.05419688
15	Genetic anticipation (HP:0003743)	2.93897259
16	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	2.79779043
17	Spontaneous abortion (HP:0005268)	2.77292099
18	Type I transferrin isoform profile (HP:0003642)	2.73547547
19	Pancreatic fibrosis (HP:0100732)	2.71848683
20	Abnormality of the labia minora (HP:0012880)	2.70794330
21	Pancreatic cysts (HP:0001737)	2.70215076
22	Reticulocytopenia (HP:0001896)	2.70045298
23	Congenital, generalized hypertrichosis (HP:0004540)	2.66278045
24	Cystic liver disease (HP:0006706)	2.61837055
25	Azoospermia (HP:0000027)	2.60743691
26	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.60322608
27	Abnormality of alanine metabolism (HP:0010916)	2.60322608
28	Hyperalaninemia (HP:0003348)	2.60322608
29	Chromosomal breakage induced by crosslinking agents (HP:0003221)	2.58633199
30	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	2.56961046
31	Abnormal protein N-linked glycosylation (HP:0012347)	2.56961046
32	Abnormal protein glycosylation (HP:0012346)	2.56961046
33	Abnormal glycosylation (HP:0012345)	2.56961046
34	Attenuation of retinal blood vessels (HP:0007843)	2.54482469
35	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.45183737
36	Broad metatarsal (HP:0001783)	2.41619358
37	Duplicated collecting system (HP:0000081)	2.39380949
38	Retinal dysplasia (HP:0007973)	2.33876258
39	Duplication of thumb phalanx (HP:0009942)	2.33501728
40	Birth length less than 3rd percentile (HP:0003561)	2.30831134
41	Medial flaring of the eyebrow (HP:0010747)	2.28647107
42	Progressive cerebellar ataxia (HP:0002073)	2.26200934
43	Respiratory difficulties (HP:0002880)	2.24227342
44	Abnormal spermatogenesis (HP:0008669)	2.24160927
45	Increased hepatocellular lipid droplets (HP:0006565)	2.21336432
46	Hypoplasia of the pons (HP:0012110)	2.20122165
47	Inability to walk (HP:0002540)	2.18356815
48	Abnormality of the renal collecting system (HP:0004742)	2.17401148
49	Chromsome breakage (HP:0040012)	2.16199209
50	Congenital primary aphakia (HP:0007707)	2.13824971
51	Cerebellar dysplasia (HP:0007033)	2.13816054
52	Non-midline cleft lip (HP:0100335)	2.10456834
53	Male pseudohermaphroditism (HP:0000037)	2.10400464
54	Large for gestational age (HP:0001520)	2.08938448
55	Gaze-evoked nystagmus (HP:0000640)	2.08656324
56	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	2.06451925
57	Protruding tongue (HP:0010808)	2.06000463
58	Gait imbalance (HP:0002141)	2.05838703
59	Aplasia/Hypoplasia affecting the fundus (HP:0008057)	2.01946240
60	Stenosis of the external auditory canal (HP:0000402)	2.00940406
61	Renal Fanconi syndrome (HP:0001994)	1.99147928
62	Stage 5 chronic kidney disease (HP:0003774)	1.98935875
63	Confusion (HP:0001289)	1.96887290
64	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.96179915
65	Sclerocornea (HP:0000647)	1.94756607
66	Bony spicule pigmentary retinopathy (HP:0007737)	1.94329879
67	Volvulus (HP:0002580)	1.92462537
68	Preaxial hand polydactyly (HP:0001177)	1.90178138
69	Abnormality of the pons (HP:0007361)	1.88222361
70	Ectopic kidney (HP:0000086)	1.86170230
71	Preaxial foot polydactyly (HP:0001841)	1.84626015
72	Congenital sensorineural hearing impairment (HP:0008527)	1.84299437
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.83487068
74	Vaginal atresia (HP:0000148)	1.82928924
75	Genital tract atresia (HP:0001827)	1.82627578
76	Lipid accumulation in hepatocytes (HP:0006561)	1.82614212
77	Increased CSF lactate (HP:0002490)	1.82358800
78	Nephrogenic diabetes insipidus (HP:0009806)	1.81151810
79	Abolished electroretinogram (ERG) (HP:0000550)	1.79030514
80	Absent radius (HP:0003974)	1.78627332
81	Gonadotropin excess (HP:0000837)	1.78109905
82	Tubulointerstitial abnormality (HP:0001969)	1.78037273
83	Hyperglycinuria (HP:0003108)	1.77708955
84	Methylmalonic acidemia (HP:0002912)	1.73519709
85	Aplasia involving forearm bones (HP:0009822)	1.72996696
86	Absent forearm bone (HP:0003953)	1.72996696
87	Amelogenesis imperfecta (HP:0000705)	1.72247782
88	Colon cancer (HP:0003003)	1.71461343
89	Small hand (HP:0200055)	1.71040107
90	Duodenal stenosis (HP:0100867)	1.70889076
91	Small intestinal stenosis (HP:0012848)	1.70889076
92	Abnormality of macular pigmentation (HP:0008002)	1.70552775
93	Abnormality of dentin (HP:0010299)	1.70508129
94	Aplasia/Hypoplasia of the uvula (HP:0010293)	1.70271757
95	Prominent supraorbital ridges (HP:0000336)	1.69572042
96	Large hands (HP:0001176)	1.68195887
97	Hypoplastic ischia (HP:0003175)	1.68084798
98	Intellectual disability, profound (HP:0002187)	1.67961708
99	Abnormal number of erythroid precursors (HP:0012131)	1.66927676
100	Severe visual impairment (HP:0001141)	1.66832300

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	PNCK	6.22805806
2	TLK1	4.63198276
3	FRK	3.89739500
4	CDK19	3.45631322
5	INSRR	3.21701676
6	BUB1	2.90644383
7	PDK2	2.63499462
8	BMPR1B	2.48696088
9	OXSR1	2.47482289
10	PTK2B	2.45187881
11	MET	2.30027847
12	PLK4	2.16719090
13	LATS1	2.08398793
14	ADRBK2	2.01141338
15	PLK2	1.79562116
16	NEK2	1.75964253
17	WEE1	1.73352246
18	CAMK1G	1.65061033
19	EPHA3	1.62757818
20	ZAK	1.61920371
21	NUAK1	1.49750511
22	BMX	1.48856163
23	FGFR2	1.44092030
24	STK39	1.41744428
25	TGFBR1	1.41321175
26	SIK2	1.40519804
27	NEK9	1.35937903
28	ACVR1B	1.33387357
29	NTRK3	1.22840100
30	MAP3K12	1.22117025
31	WNK3	1.21665615
32	PLK1	1.20326991
33	VRK1	1.19569475
34	NEK1	1.17207201
35	FGR	1.12392730
36	STK38L	1.09694019
37	WNK4	1.01648032
38	BRSK1	1.00254576
39	VRK2	1.00070446
40	PLK3	0.99981764
41	BRD4	0.91935497
42	TTK	0.90342300
43	GRK1	0.87424477
44	PASK	0.82969470
45	MAP3K13	0.80219865
46	MKNK2	0.77841173
47	EIF2AK3	0.75792510
48	MKNK1	0.74561553
49	MAP3K9	0.71549649
50	CSF1R	0.70703928
51	STK3	0.68848680
52	AKT3	0.66555770
53	ADRBK1	0.66207281
54	MAP3K2	0.63241576
55	DYRK1A	0.62996697
56	BRSK2	0.62257391
57	ATR	0.61808796
58	NME2	0.61680244
59	CASK	0.60416942
60	TAF1	0.56389669
61	STK38	0.54663554
62	CHEK2	0.54315286
63	EPHA4	0.53250410
64	WNK1	0.53127364
65	NME1	0.52950526
66	CDC7	0.48071175
67	PRKCG	0.47334998
68	MAPKAPK5	0.42751863
69	FLT3	0.39352297
70	PTK2	0.38116689
71	MAPK11	0.37149581
72	SGK223	0.36209936
73	SGK494	0.36209936
74	MAP3K4	0.35749036
75	CDK7	0.35494619
76	AURKA	0.34540038
77	CDK1	0.34121356
78	RET	0.34027478
79	MST4	0.32576289
80	MELK	0.32185265
81	PRKCI	0.31369655
82	TYRO3	0.31265439
83	KSR2	0.31125168
84	LMTK2	0.31038810
85	CAMK1	0.31029580
86	AURKB	0.30712619
87	CHEK1	0.29674489
88	NEK6	0.29315170
89	SGK2	0.29166511
90	BRAF	0.28619173
91	ATM	0.27238817
92	MYLK	0.27031032
93	PDK1	0.26635322
94	FGFR1	0.26567125
95	KSR1	0.26365415
96	CSNK1E	0.26023537
97	SGK1	0.25586311
98	STK16	0.25344608
99	CAMK2A	0.25228137
100	MAP2K1	0.24001318

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Homologous recombination_Homo sapiens_hsa03440	3.67104965
2	Phototransduction_Homo sapiens_hsa04744	3.55497086
3	Ribosome_Homo sapiens_hsa03010	2.70996655
4	Mismatch repair_Homo sapiens_hsa03430	2.69235745
5	Oxidative phosphorylation_Homo sapiens_hsa00190	2.56087779
6	Parkinsons disease_Homo sapiens_hsa05012	2.55374598
7	Selenocompound metabolism_Homo sapiens_hsa00450	2.45430407
8	Huntingtons disease_Homo sapiens_hsa05016	2.24372806
9	Fanconi anemia pathway_Homo sapiens_hsa03460	2.21630408
10	Linoleic acid metabolism_Homo sapiens_hsa00591	2.08356891
11	DNA replication_Homo sapiens_hsa03030	1.98125714
12	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.94987933
13	RNA polymerase_Homo sapiens_hsa03020	1.91617616
14	RNA transport_Homo sapiens_hsa03013	1.88303355
15	Cell cycle_Homo sapiens_hsa04110	1.86883165
16	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.83232675
17	Propanoate metabolism_Homo sapiens_hsa00640	1.82698111
18	Protein export_Homo sapiens_hsa03060	1.63656970
19	Cardiac muscle contraction_Homo sapiens_hsa04260	1.56227095
20	Oocyte meiosis_Homo sapiens_hsa04114	1.52752227
21	Cysteine and methionine metabolism_Homo sapiens_hsa00270	1.52541121
22	Pyruvate metabolism_Homo sapiens_hsa00620	1.52294569
23	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.50635129
24	Nucleotide excision repair_Homo sapiens_hsa03420	1.50181087
25	Olfactory transduction_Homo sapiens_hsa04740	1.49107794
26	Alzheimers disease_Homo sapiens_hsa05010	1.49074699
27	Butanoate metabolism_Homo sapiens_hsa00650	1.47969980
28	Taste transduction_Homo sapiens_hsa04742	1.47623219
29	Regulation of autophagy_Homo sapiens_hsa04140	1.47148639
30	RNA degradation_Homo sapiens_hsa03018	1.38768445
31	Ether lipid metabolism_Homo sapiens_hsa00565	1.37081352
32	ABC transporters_Homo sapiens_hsa02010	1.34400210
33	Base excision repair_Homo sapiens_hsa03410	1.34290972
34	Nitrogen metabolism_Homo sapiens_hsa00910	1.32421345
35	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	1.31645772
36	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	1.28278611
37	Basal transcription factors_Homo sapiens_hsa03022	1.25946457
38	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.22401616
39	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	1.20062992
40	Fat digestion and absorption_Homo sapiens_hsa04975	1.18654744
41	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.14672551
42	Nicotine addiction_Homo sapiens_hsa05033	1.13363747
43	Sulfur relay system_Homo sapiens_hsa04122	1.13075155
44	Purine metabolism_Homo sapiens_hsa00230	1.07364996
45	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.06004943
46	Pyrimidine metabolism_Homo sapiens_hsa00240	1.05914605
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	1.04846080
48	Hedgehog signaling pathway_Homo sapiens_hsa04340	1.04032814
49	beta-Alanine metabolism_Homo sapiens_hsa00410	1.02970942
50	Tryptophan metabolism_Homo sapiens_hsa00380	1.02386632
51	Serotonergic synapse_Homo sapiens_hsa04726	1.02239484
52	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.98804928
53	Morphine addiction_Homo sapiens_hsa05032	0.98072903
54	Proteasome_Homo sapiens_hsa03050	0.91276163
55	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.90884872
56	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.89705102
57	Spliceosome_Homo sapiens_hsa03040	0.85056093
58	Non-homologous end-joining_Homo sapiens_hsa03450	0.84040450
59	Circadian rhythm_Homo sapiens_hsa04710	0.75499689
60	Glycerolipid metabolism_Homo sapiens_hsa00561	0.75455901
61	Glutamatergic synapse_Homo sapiens_hsa04724	0.71658122
62	Lysine degradation_Homo sapiens_hsa00310	0.69519156
63	mRNA surveillance pathway_Homo sapiens_hsa03015	0.66399222
64	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.63469186
65	Basal cell carcinoma_Homo sapiens_hsa05217	0.62906054
66	Calcium signaling pathway_Homo sapiens_hsa04020	0.62524577
67	Maturity onset diabetes of the young_Homo sapiens_hsa04950	0.61281190
68	Metabolic pathways_Homo sapiens_hsa01100	0.61008667
69	Retinol metabolism_Homo sapiens_hsa00830	0.60836806
70	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.60598659
71	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.59548509
72	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.57904870
73	Caffeine metabolism_Homo sapiens_hsa00232	0.56353491
74	GABAergic synapse_Homo sapiens_hsa04727	0.54065386
75	Circadian entrainment_Homo sapiens_hsa04713	0.53663232
76	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.52095455
77	Protein digestion and absorption_Homo sapiens_hsa04974	0.50483315
78	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.50113314
79	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.49272812
80	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.47468322
81	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.47376810
82	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.46534814
83	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.46146938
84	One carbon pool by folate_Homo sapiens_hsa00670	0.46095037
85	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	0.45327438
86	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.43631773
87	Renin-angiotensin system_Homo sapiens_hsa04614	0.43047870
88	Glutathione metabolism_Homo sapiens_hsa00480	0.41752998
89	Arginine and proline metabolism_Homo sapiens_hsa00330	0.41655450
90	Mineral absorption_Homo sapiens_hsa04978	0.41550156
91	Chemical carcinogenesis_Homo sapiens_hsa05204	0.40121253
92	Fatty acid degradation_Homo sapiens_hsa00071	0.39266096
93	Tyrosine metabolism_Homo sapiens_hsa00350	0.36190781
94	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.35528462
95	Salivary secretion_Homo sapiens_hsa04970	0.29046327
96	Phenylalanine metabolism_Homo sapiens_hsa00360	0.28549466
97	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.28141782
98	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.25456957
99	Fatty acid metabolism_Homo sapiens_hsa01212	0.25227957
100	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.25200701

CXADRP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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